Akiba Satoshi 秋葉聡

… Alternative Names

秋葉聡アキバサトシ

AKIBA Satoshi 秋葉聡

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Researcher Number	70231826
Other IDs
External Links
Affiliation (Current)	2023: 京都薬科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2023: 京都薬科大学, 薬学部, 教授 2014 – 2021: 京都薬科大学, 薬学部, 教授 2008 – 2010: Kyoto Pharmaceutical University, 薬学部, 教授 2000 – 2004: 京都薬科大学, 薬学部, 助教授 1995: 京都薬科大学, 薬学部, 助手 1993: 京都薬科大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Biological pharmacy / Pharmacology in pharmacy / Basic Section 47040:Pharmacology-related / Biological pharmacy
Keywords	Principal Investigator ホスホリパーゼA_2 / マクロファージ / ホスホリパーゼA2 / 炎症 / 血小板 / 粥状動脈硬化症 / 非アルコール性脂肪肝炎 / 細胞骨格系タンパク質 / GTP結合タンパク質 / プロテインキナーゼC … More / アラキドン酸 / スカベンジャー受容体 / ファゴサイトーシス / 生化学 / メタボリックシンドローム / 非アルコール性脂肪肝 / ホスホリパーゼ / アディポサイトカイン / 肝線維化 / 炎症反応 / コレステロールエステル / 泡沫細胞 / 泡沫化 / atherosclerosis / phospholipase A_2 / macrophages / cholesteryl ester / foam cells / 脂肪肝炎 / IVA型ホスホリパーゼA2 Less

高脂肪食負荷解除下での肝線維化修復促進を狙ったＩＶＡ型ＰＬＡ２の細胞種特異的制御Principal Investigator
- Principal Investigator
  
  秋葉聡
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Kyoto Pharmaceutical University
Inhibition of liver fibrosis by cell type-specific deficiency of group IVA PLA2 as a novel therapeutic strategy for NASHPrincipal Investigator
- Principal Investigator
  
  秋葉聡
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Kyoto Pharmaceutical University
Inhibition of group IVA phospholipase A2 as a therapeutic strategy for non-alcoholic steatohepatitisPrincipal Investigator
- Principal Investigator
  
  Akiba Satoshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Kyoto Pharmaceutical University
Involvement of group IVA phospholipase A2 in the development and progression of non-alcoholic steatohepatitisPrincipal Investigator
- Principal Investigator
  
  Akiba Satoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Kyoto Pharmaceutical University
Mechanisms for the development of atherosclerosis with low HDL levels and of fatty liverPrincipal Investigator
- Principal Investigator
  
  AKIBA Satoshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyoto Pharmaceutical University
Role of phospholipase A_2 in the cellular responses contributing to atherogenesisPrincipal Investigator
- Principal Investigator
  
  AKIBA Satoshi
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyoto Pharmaceutical University
スカベンジャー受容体を介したVI型ホスホリパーゼA_2の活性化機構の解明Principal Investigator
- Principal Investigator
  
  秋葉聡
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyoto Pharmaceutical University
血小板細胞質ホスホリパーゼA_2の細胞膜上での活性発現機構に関する研究Principal Investigator
- Principal Investigator
  
  秋葉聡
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyoto Pharmaceutical University
血小板の細胞質ホスホリパーゼA_2活性発現への細胞骨格系タンパク質の関与Principal Investigator
- Principal Investigator
  
  秋葉聡
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyoto Pharmaceutical University

[Book] Role of phospholipase A_2 in foam cell formation in macrophages. Biochemistry of Lipids in Vascular Function (Mario Alberghina Ed.)2004
- Author(s)
  Satohi Akiba, Takashi Sato
- Publisher
  Research Signpost
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572083
[Book] Role of phospholipase A_2 in foam cell formation in macrophages. Biochemistry of Lipids in Vascular Function,(Mario Alberghina Ed.)2004
- Author(s)
  Satoshi Akiba, Takashi Sato
- Publisher
  Research Signpost
- Data Source
  KAKENHI-PROJECT-14572083
[Journal Article] Endothelial group IVA phospholipase A2 promotes hepatic fibrosis with sinusoidal capillarization in the early stage of non-alcoholic steatohepatitis in mice2022
- Author(s)
  Kawashita E., Ozaki T., Ishihara K., Kashiwada C., AkibaS.
- Journal Title
  
  Life Sciences
  
  Volume: 294 Pages: 120355-120355
- DOI
  10.1016/j.lfs.2022.120355
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07077
[Journal Article] A comparative analysis of hepatic pathological phenotypes in C57BL/6J and C57BL/6N mouse strains in non-alcoholic steatohepatitis models.2019
- Author(s)
  Eri Kawashita, Keiichi Ishihara, Madoka Nomoto, Mika Taniguchi, Satoshi Akiba
- Journal Title
  
  Sci. Rep.
  
  Volume: 9 Pages: 204-204
- DOI
  10.1038/s41598-018-36862-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08322
[Journal Article] ASB14780, an Orally Active Inhibitor of Group IVA Phospholipase A2, Is a Pharmacotherapeutic Candidate for Nonalcoholic Fatty Liver Disease.2016
- Author(s)
  Kanai S, Ishihara K, Kawashita E, Tomoo T, Nagahira K, Hayashi Y, Akiba S.
- Journal Title
  
  J. Pharmaco.l Exp. Ther.
  
  Volume: 356 Pages: 604-614
- DOI
  10.1124/jpet.115.229906
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460077, KAKENHI-PROJECT-26460110
[Journal Article] Group IVA phospholipase A2 deficiency prevents CCl4-induced hepatic cell death through the enhancement of autophagy.2016
- Author(s)
  Ishihara K, Kanai S, Tanaka K, Kawashita E, Akiba S.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 471 Pages: 15-20
- DOI
  10.1016/j.bbrc.2016.01.186
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460077, KAKENHI-PROJECT-26460110
[Journal Article] Triacylglycerol deposition with group IVC phospholipase A_2 expression in oleate- and linoleate-stimulated Huh-7 hepatocytes.2011
- Author(s)
  Keiichi Ishihara, Kengo Tachibana, Asuka Kuroda, Ayano Terakawa, Shinsuke Baba, Shiho Kanai, Satoshi Akiba
- Journal Title
  
  Biol.Pharm.Bull. 34
  
  Pages: 191-196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590072
[Journal Article] Alleviation of high-fat diet-induced fatty liver damage in group IVA phospholipase A_2-knockout mice.2009
- Author(s)
  Hiromi Ii, Naoki Yokoyama, Shintaro Yoshida, Kae Tsutsumi, Shinji Hatakeyama, Takashi Sato, Keiichi Ishihara, Satoshi Akiba
- Journal Title
  
  PLoS ONE. 4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590072
[Journal Article] Hypoxia stimulates the autocrine regulation of migration of vascular smooth muscle cells via HIF-1α-dependent expression of thrombospondin-1.2008
- Author(s)
  Mayuko Osada-Oka, Takako Ikeda, Satoshi Akiba, Takashi Sato
- Journal Title
  
  J.Cell.Biochem. 104
  
  Pages: 1918-1926
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590072
[Journal Article] Group IVA phospholipase A_2 is associated with the storage of lipids in adipose tissue and liver.2008
- Author(s)
  Hiromi Ii, Shinji Hatakeyama, Kae Tsutsumi, Takashi Sato, Satoshi Akiba
- Journal Title
  
  Prostaglandins Other Lipid Mediat. 86
  
  Pages: 12-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590072
[Journal Article] Role of phospholipase A_2 in foam cell formation in macrophages2004
- Author(s)
  Satoshi Akiba, Takashi Sato
- Journal Title
  
  Biochemistry of Lipids in Vascular Function (Mario Alberghina Ed.) (Research Signpost)
  
  Pages: 29-46
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572083
[Journal Article] Translocation of phospholipase A_2 to membranes by oxidized LDL and hydroxyoctadecadienoic acid to contribute to cholesteryl ester. formation2004
- Author(s)
  Satoshi Akiba, Hiromi Ii, Yukimasa Yoneda, Takashi Sato
- Journal Title
  
  Biochim. Biophys. Acta 1686
  
  Pages: 77-84
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572083
[Journal Article] Translocation of phospholipase A_2 to membranes by oxidized LDL and hydroxyoctadecadienoic acid to contribute to cholesteryl ester formation.2004
- Author(s)
  Satoshi Akiba, Hiromi Ii, Yukimasa Yoneda, Takashi Sato
- Journal Title
  
  Biochim.Biophys.Acta 1686
  
  Pages: 77-84
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572083
[Journal Article] The leaf extract of Ginkgo Biloba L.suppresses oxidized LDL-stimulated fibronectin production through an antioxidant action in rat mesangial cells.2004
- Author(s)
  Satoshi Akiba, Masahiro Chiba, Yuki Mukaida, Akira Tamura, Takashi Sato
- Journal Title
  
  Br.J.Pharmacol. 142
  
  Pages: 419-424
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572083
[Journal Article] The leaf extract of Ginkgo Biloba L.suppresses oxidized LDL-stimulated fibronectin production through an antioxidant action in rat mesangial cells.2004
- Author(s)
  Satoshi Akiba, Masahiro Chiba, Yuki Mukaida, Akita Tamura, Takashi Sato
- Journal Title
  
  Br.J.Pharmacol. 142
  
  Pages: 419-424
- Data Source
  KAKENHI-PROJECT-14572083
[Journal Article] Oxidized LDL activates phospholipase A_2 to supply fatty acids required for cholesterol esterification2003
- Author(s)
  Satoshi Akiba, Yukimasa Yoneda, Satoshi Ohno, Megumi Nemoto, Takashi Sato
- Journal Title
  
  J.Lipid Res. 44
  
  Pages: 1676-1685
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572083
[Journal Article] Oxidized LDL activates phospholipase A_2 to supply fatty acids required for cholesterol esterification.2003
- Author(s)
  Satoshi Akiba, Yukimasa Yoneda, Satoshi Ohno, Megumi Nemoto, Takashi Sato
- Journal Title
  
  J.Lipid Res. 44
  
  Pages: 1676-1685
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572083
[Journal Article] Involvement of reactive oxygen species and SP-1 in fibronectin production by oxidized LDL.2003
- Author(s)
  Satoshi Akiba, Masahiro Chiba, Yuki Mukaida, Takashi Sato
- Journal Title
  
  Biochem.Biophys.Res.Commun. 310
  
  Pages: 491-497
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572083
[Journal Article] マクロファージでのコレステロールエステルの蓄積過程におけるリン脂質代謝の役割2003
- Author(s)
  秋葉聡
- Journal Title
  
  薬学雑誌 123
  
  Pages: 845-853
- NAID
  110003614848
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572083
[Journal Article] Involvement of reactive oxygen species and SP-1 in fibronectin production by oxidized LDL2003
- Author(s)
  Satoshi Akiba, Masahiro Chiba, Yuki Mukaida, Takashi Sato
- Journal Title
  
  Biochem.Biophys.Res.Commun. 310
  
  Pages: 491-497
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572083
[Journal Article] Stimulation by de novo-synthesized ceramide of phospholipase A_2-dependent cholesterol esterification promoted by the uptake of oxidized low-density lipoprotein in macrophages2002
- Author(s)
  Kazuyuki Kitatani, Megumi Nemoto, Satoshi Akiba, Takashi Sato
- Journal Title
  
  Cell.Signal. 14
  
  Pages: 695-701
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572083
[Journal Article] Stimulation by de novo-synthesized ceramide of phospholipase A_2-dependent cholesterol esterification promoted by the uptake of oxidized low-density lipoprotein in macrophages.2002
- Author(s)
  Kazuyuki Kitatani, Megumi Nemoto, Satoshi Akiba, Takashi Sato
- Journal Title
  
  Cell.Signal. 14
  
  Pages: 695-701
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572083
[Presentation] 肝星細胞のIVA型ホスホリパーゼA2欠損による肝線維化の修復促進2021
- Author(s)
  泰地健芳, 河下映里, 石原慶一, 木村徹也，秋葉　聡
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K07077
[Presentation] 肝星細胞のIVA型ホスホリパーゼA2欠損による肝線維化の修復促進2021
- Author(s)
  泰地健芳, 河下映里, 石原慶一, 木村徹也, 秋葉　聡
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K07077
[Presentation] NASH病態進展および肝修復過程における肝星細胞のIVA-PLA2の役割2020
- Author(s)
  泰地健芳, 河下映里, 石原慶一, 木村徹也, 保田史織, 秋葉　聡
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-17K08322
[Presentation] 非アルコール性脂肪肝炎に対する細胞特異的IVA型ホスホリパーゼA2欠損の影響2020
- Author(s)
  泰地健芳, 河下映里, 石原慶一, 秋葉　聡
- Organizer
  第70回日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-20K07077
[Presentation] NASH肝線維化進展における内皮細胞のIVA型ホスホリパーゼA2の関与2020
- Author(s)
  松代美礼, 河下映里, 石原慶一, 泰地健芳, 奥村綾茄, 親川奈未, 秋葉　聡
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-17K08322
[Presentation] 高脂肪食誘発性動脈硬化の病変形成に対する単球・マクロファージおよび血管内皮細胞特異的IVA-PLA2欠損の影響2019
- Author(s)
  氏家真梨子, 河下映里, 金井志帆, 石原慶一, 田川　南, 苅田紗季, 秋葉　聡
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K08322
[Presentation] 非アルコール性脂肪肝炎マウスモデルにおけるC57BL/6JおよびC57BL/6N亜系統間での表現型の相違2019
- Author(s)
  野本真斗香, 河下映里, 石原慶一, 谷口実花, 秋葉　聡
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K08322
[Presentation] 細胞種特異的IVA型ホスホリパーゼA2欠損による非アルコール性脂肪肝炎の病態軽減効果2019
- Author(s)
  泰地健芳, 河下映里, 石原慶一, 秋葉　聡
- Organizer
  第9回4大学連携研究フォーラム
- Data Source
  KAKENHI-PROJECT-17K08322
[Presentation] 非アルコール性脂肪肝炎の新規治療標的としての内皮細胞のIVA型ホスホリパーゼA2の可能性2019
- Author(s)
  加納菜瑠実, 河下映里, 石原慶一, 柏田千紘, 泰地健芳, 長尾美奈, 米岡那夏子, 村岡理沙子, 親川奈未, 秋葉　聡
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K08322
[Presentation] IVA型ホスホリパーゼA2に着目した肝線維化の進展機構の解明2018
- Author(s)
  秋葉　聡
- Organizer
  第54回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-17K08322
[Presentation] NASHの新規治療観点としてのIVA型ホスホリパーゼA2の阻害2018
- Author(s)
  秋葉　聡、河下映里、石原慶一
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K08322
[Presentation] 細胞培養系を用いたNASH病態進展におけるIVA型phospholipase A2の機能解析．2017
- Author(s)
  今田百南，河下映里，石原慶一，江川奈生，木原　望，倉田麻未，種草大貴，秋葉　聡
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-26460110
[Presentation] 酸化ストレス誘発性肝線維化の進展過程におけるIVA型ホスホリパーゼA2の役割の解明．2017
- Author(s)
  福本紗与，河下映里，石原慶一，泰地健芳，秋葉　聡
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-26460110
[Presentation] IVA型PLA2欠損下でのNASH病態軽減に関与する細胞種の特定2017
- Author(s)
  河下映里、石原慶一、柏田千紘、泰地健芳、長尾美奈、加納菜瑠実、米岡那夏子、金井志帆、秋葉　聡
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K08322
[Presentation] 各種肝構成細胞での脂肪酸刺激によるmonocyte chemotactic protein-1発現誘導へのIVA型PLA2の関与2017
- Author(s)
  中本彩奈、中西李澄、今田百南、河下映里、石原慶一、秋葉　聡
- Organizer
  第67回日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-17K08322
[Presentation] 酸化ストレス誘発性肝障害におけるIVA型ホスホリパーゼA2の役割．2016
- Author(s)
  藤井美恵子、河下映里、石原慶一、秋葉　聡
- Organizer
  日本薬学会第136年会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26460110
[Presentation] NASH進展に関与する肝細胞及びマクロファージにおける IVA型phospholipase A2の役割．2016
- Author(s)
  種草大貴、河下映里、石原慶一、秋葉聡
- Organizer
  第66回日本薬学会近畿支部総会・大会
- Place of Presentation
  高槻
- Data Source
  KAKENHI-PROJECT-26460110
[Presentation] 動脈硬化症におけるM2型マクロファージ極性化へのIVA型ホスホリパーゼA2の関与．2015
- Author(s)
  木原　望、金井志帆、厚味厳一、河下映里、石原慶一、秋葉　聡
- Organizer
  第88回日本生化学会大会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26460110
[Presentation] IVA型ホスホリパーゼA2の欠損による肝細胞オートファジーの促進．2015
- Author(s)
  田中紀久子、和田尚子、吉田彩奈加、河下映里、石原慶一、秋葉　聡
- Organizer
  第65回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪府富田林市
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-26460110
[Presentation] 脂肪肝形成に対する経口性IVA型ホスホリパーゼA2阻害剤の抑制効果．2014
- Author(s)
  金井志帆、倉井悠貴、古庄由佳、西川瑞稀、石原慶一、秋葉　聡
- Organizer
  第61回日本生化学会近畿支部例会
- Place of Presentation
  京都市
- Year and Date
  2014-05-17
- Data Source
  KAKENHI-PROJECT-26460110
[Presentation] 肝線維化誘発 IVA型Phospholipase A2欠損マウスにおける脾臓肥大．2014
- Author(s)
  松岡秀明、大西健太、石原慶一、金井志帆、秋葉聡
- Organizer
  第64回日本薬学会近畿支部総会・大会
- Place of Presentation
  京都市
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-26460110
[Presentation] IVA型Phospholipase A2欠損による薬剤誘発性肝障害の抑制．2014
- Author(s)
  和田尚子、金井志帆、石原慶一、秋葉聡
- Organizer
  第64回日本薬学会近畿支部総会・大会
- Place of Presentation
  京都市
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-26460110
[Presentation] マクロファージのアポトーシスの抑制を介したIVA型ホスホリパーゼA_2の粥状動脈硬化巣形成への関与2011
- Author(s)
  金井志帆、重村侑哉、金又聡美、濱野稚紗、米川昌輝、石原慶一、秋葉聡
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] IVA型ホスホリパーゼA_2欠損による肝線維化抑制2011
- Author(s)
  伏見英晃、宮崎晃、横山直記、金井志帆、石原慶一、秋葉聡
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] Alleviation of high-fat diet-induced fatty liver damage and adipose accumulation in group IVA phospholipase A_2-knockout mice.2010
- Author(s)
  Satoshi Akiba
- Organizer
  The 1st International Congress on Abdominal Obesity
- Place of Presentation
  The Hong Kong convention and Exhibition Centre (Hong Kong)
- Year and Date
  2010-01-30
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] Deficiency of group IVA phospholipase A_2 alleviates high-fat diet-induced atherosclerotic lesion formation without improving dyslipidemia2010
- Author(s)
  秋葉聡, 重村侑哉, 石原慶一
- Organizer
  第42回日本動脈硬化学会総会・学術集会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] プロテオミクス解析を用いたIVA型ホスホリパーゼA_2の欠損による非アルコール性脂肪肝形成の抑制に関連する分子の探索2010
- Author(s)
  宮崎晃、横山直記、金井志帆、石原慶一、秋葉聡
- Organizer
  第60回日本薬学会近畿支部総会・大会
- Place of Presentation
  枚方
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] 内臓脂肪組織における慢性炎症へのIVA型ホスホリパーゼA_2の関与2010
- Author(s)
  三田景子、中田裕子、金井志帆、石原慶一、秋葉聡
- Organizer
  第60回日本薬学会近畿支部総会・大会
- Place of Presentation
  枚方
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] IVA型ホスホリパーゼA_2欠損マウスにおける粥状動脈硬化症進展の抑制とその機構2010
- Author(s)
  重村侑哉、金又聡美、米川昌輝、濱野稚紗、石原慶一、秋葉聡
- Organizer
  難病克服を目指した分子基盤創薬科学の開拓成果発表会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] 単球芽細胞THP-1細胞のマクロファージ様細胞への分化成熟における細胞質ホスホリパーゼA_2Yの役割2010
- Author(s)
  黒田明日香、杉原佳奈子、鈴木麻央、丹治里奈、石原慶一、秋葉聡
- Organizer
  難病克服を目指した分子基盤創薬科学の開拓成果発表会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] 高脂肪食投与下のIVA型ホスホリパーゼA_2欠損マウスにおける脂肪肝形成および肝線維化の抑制2010
- Author(s)
  横山直記、石原慶一、秋葉聡
- Organizer
  難病克服を目指した分子基盤創薬科学の開拓成果発表会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] 高脂肪食投与下のIVA型ホスホリパーゼA_2欠損マウスはHDLの低下を改善することなく粥状動脈硬化病変形成を軽減する2010
- Author(s)
  金井志帆、重村侑哉、金又聡美、濱野稚紗、米川昌輝、石原慶一、秋葉聡
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] ヒト肝癌由来HuH-7細胞におけるトリアシルグリセロール蓄積への細胞質ホスホリパーゼA_<2γ>の関与2010
- Author(s)
  寺井建太、馬場信輔、寺川綾乃、石原慶一、秋葉聡
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] IVA PLA_2-mediated fatty liver with fibrosis in mice fed high-fat diets.2010
- Author(s)
  横山直記, 石原慶一, 秋葉聡
- Organizer
  2010 Keystone Symposia Bioactive Lipids : Biochemistry and Diseases
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] Alleviation of high-fat diet-induced fatty liver damage and adipose accumulation in group IVA phospholipase A_2-knockout mice2010
- Author(s)
  秋葉聡, 横山直記, 飯居宏美, 石原慶一
- Organizer
  The 1st International Congress on Abdominal Obesity
- Place of Presentation
  Hong Kong
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] Deficiency of group IVA phospholipase A_2 alleviates high-fat diet-induced atherosclerotic lesion formation without improving dyslipidemia.2010
- Author(s)
  Satoshi Akiba
- Organizer
  第42回日本動脈硬化学会総会・学術集会
- Place of Presentation
  岐阜都ホテル(岐阜)
- Year and Date
  2010-07-15
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] IVA型ホスホリパーゼA_2欠損マウスの脂肪肝形成の抑制因子のプロテオミクス解析による同定2010
- Author(s)
  宮崎晃、横山直記、石原慶一、秋葉聡
- Organizer
  難病克服を目指した分子基盤創薬科学の開拓成果発表会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] IVA型ホスホリパーゼA_2の欠損による高脂肪食誘発性脂肪肝の抑制に関連する分子の同定2010
- Author(s)
  宮崎晃、横山直記、石原慶一、秋葉聡
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] IVA型ホスホリパーゼA_2欠損マウスにおける高脂肪食投与に伴う脂肪肝の抑制因子の網羅的解析2010
- Author(s)
  宮崎晃、横山直記、金井志帆、石原慶一、秋葉聡
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] マクロファージの分化成熟過程におけるIVC型ホスホリパーゼA_2の役割2010
- Author(s)
  寺井建太、黒田明日香、堀内映里、杉原佳奈子、金井志帆、石原慶一、秋葉聡
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] IVA型ホスホリパーゼA_2欠損マウスにおける高脂肪食投与に伴うHDL低下と脂肪線条形成の抑制2009
- Author(s)
  重村侑哉、石原慶一、秋葉聡
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] Improvement of high-fat diet-induced fat accumulation with inflammation in the liver in group IVA phospholipase A_2-knockout mice.2009
- Author(s)
  横山直記, 飯居宏美, 秋葉聡
- Organizer
  4th International Conference on Phospholipase A_2 and Lipid Mediators
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] 脂肪組織および肝における脂肪蓄積へのIVA型ホスホリパーゼA_2の関与2009
- Author(s)
  横山直記、飯居宏美、秋葉聡
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] Group IVA phospholipase A_2 in adipose accumulation and fatty liver.2009
- Author(s)
  秋葉聡
- Organizer
  4th International Conference on Phospholipase A_2 and Lipid Mediators
- Place of Presentation
  学術総合センター(東京都)
- Year and Date
  2009-05-26
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] 脂肪組織および肝での脂肪蓄積へのIVA型ホスホリパーゼA_2の関与2009
- Author(s)
  横山直記、石原慶一、秋葉聡
- Organizer
  第14回アディポサイエンス研究会シンポジウム
- Place of Presentation
  豊中
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] IVA型ホスホリパーゼA_2欠損マウスにおける高脂肪食投与に伴うHDL産生低下と脂肪線条形成の抑制2009
- Author(s)
  重村侑哉、飯居宏美、秋葉聡
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] 脂肪組織および肝における脂肪蓄積へのIVA型ホスホリパーゼA_2の関与2009
- Author(s)
  横山直記、石原慶一、秋葉聡
- Organizer
  第59回日本薬学会近畿支部総会・大会
- Place of Presentation
  東大阪
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] Group IVA phospholipase A_2 in adipose accumulation and fatty liver2009
- Author(s)
  秋葉聡
- Organizer
  4th International Conference on Phospholipase A_2 and Lipid Mediators
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] Suppression of atherosclerosis progression in group IVA phospholipase A_2-knockout mice.2009
- Author(s)
  Hiromi Ii, Shinji Hatakeyama, Kae Tsutsumi, Yoshie Arai, Yuya Shigemura, Satoshi Akiba
- Organizer
  4th International Conference on Phospholipase A_2 and Lipid Mediators
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] Amelioration of high-fat diet-induced fat deposition in the liver and adipose tissues in group IVA phospholipase A_2-knockout mice.2009
- Author(s)
  横山直記, 飯居宏美, 秋葉聡
- Organizer
  The 5th Takeda Science Foundation Symposium on PharmaSciences
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] IVA型ホスホリパーゼA_2欠損マウスにおける高脂肪食投与に伴う肝障害と脂肪線条形成の抑制2008
- Author(s)
  重村侑哉、飯居宏美、秋葉聡
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] 肝での脂肪蓄積へのgroup IVA phospholipase A_2の関与2008
- Author(s)
  飯居宏美、岡真優子、佐藤隆司、秋葉聡
- Organizer
  第50回日本脂質生化学会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] 高脂肪食投与下のIVA型ホスホリパーゼA_2欠損マウスにおける脂肪組織および肝での脂肪蓄積抑制2008
- Author(s)
  横山直記、飯居宏美、秋葉聡
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] IVA型ホスホリパーゼA_2の欠損に伴う非アルコール性脂肪肝の発症抑制2008
- Author(s)
  秋葉聡
- Organizer
  第58回日本薬学会近畿支部総会・大会
- Place of Presentation
  神戸市
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] ヒト肝癌由来HuH-7細胞におけるトリアシルグリセロール産生へのIVC型ホスホリパーゼA_2の関与2008
- Author(s)
  秋葉聡
- Organizer
  第40回日本動脈硬化学会総会・学術集会
- Place of Presentation
  つくば市
- Year and Date
  2008-07-11
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] Group IVA-phospholipase A_2欠損マウスでの非アルコール性脂肪肝の抑制2008
- Author(s)
  飯居宏美、岡真優子、佐藤隆司、秋葉聡
- Organizer
  第40回日本動脈硬化学会総会・学術集会
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] Amelioration of high-fat diet-induced adipose accumulation and fatty liver in group IVA phospholipase A_2-knockout mice.2008
- Author(s)
  Satoshi Akiba, Hiromi Ii, Naoki Yokoyama, Takashi Sato
- Organizer
  International Symposium on Integrated Medicinal Science-On the basis of traditional medicine to biomolecular system-
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] Amelioration of high-fat diet-induced adipose accumulation and fatty liver in group IVA phospholipase A_2-knockout mice.2008
- Author(s)
  秋葉聡
- Organizer
  International Symposium on Integrated Medicinal Science-On the basis of traditional medicine to biomolecular system-
- Place of Presentation
  京都市
- Year and Date
  2008-12-13
- Data Source
  KAKENHI-PROJECT-20590072
[Presentation] IVA型ホスホリパーゼA2の阻害による非アルコール性脂肪肝炎の抑制作用．
- Author(s)
  金井志帆、倉井悠貴、石原慶一、秋葉　聡
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸市
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460110
[Presentation] Suppressive effects of group IVA phospholipase A2-deficiency on the liver injury and hepatic fibrosis induced by oxidative stress in mice.
- Author(s)
  Shiho Kanai, Keiichi Ishihara, and Satoshi Akiba
- Organizer
  The Liver Meeting 2014
- Place of Presentation
  ボストン（米国）
- Year and Date
  2014-11-07 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-26460110
[Presentation] Amelioration of oxidative stress-induced liver injury and fibrosis by cPLA2α deficiency.
- Author(s)
  Satoshi Akiba
- Organizer
  6th international conference on Phospholipase A2 and Lipid Mediators
- Place of Presentation
  東京
- Year and Date
  2015-02-10 – 2015-02-12
- Data Source
  KAKENHI-PROJECT-26460110

1. ISHIHARA Keiichi (80340446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
2. KAWASHITA Eri (80509266)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
3. KANAI SHIHO

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Akiba Satoshi 秋葉 聡

秋葉 聡 アキバ サトシ

AKIBA Satoshi 秋葉 聡

Research Projects

Research Products

Co-Researchers

高脂肪食負荷解除下での肝線維化修復促進を狙ったＩＶＡ型ＰＬＡ２の細胞種特異的制御Principal Investigator

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Inhibition of liver fibrosis by cell type-specific deficiency of group IVA PLA2 as a novel therapeutic strategy for NASHPrincipal Investigator

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Review Section

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Inhibition of group IVA phospholipase A2 as a therapeutic strategy for non-alcoholic steatohepatitisPrincipal Investigator

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Involvement of group IVA phospholipase A2 in the development and progression of non-alcoholic steatohepatitisPrincipal Investigator

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Mechanisms for the development of atherosclerosis with low HDL levels and of fatty liverPrincipal Investigator

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Role of phospholipase A_2 in the cellular responses contributing to atherogenesisPrincipal Investigator

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スカベンジャー受容体を介したVI型ホスホリパーゼA_2の活性化機構の解明Principal Investigator

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血小板細胞質ホスホリパーゼA_2の細胞膜上での活性発現機構に関する研究Principal Investigator

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血小板の細胞質ホスホリパーゼA_2活性発現への細胞骨格系タンパク質の関与Principal Investigator

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[Book] Role of phospholipase A_2 in foam cell formation in macrophages. Biochemistry of Lipids in Vascular Function (Mario Alberghina Ed.)2004

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[Book] Role of phospholipase A_2 in foam cell formation in macrophages. Biochemistry of Lipids in Vascular Function,(Mario Alberghina Ed.)2004

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[Journal Article] Endothelial group IVA phospholipase A2 promotes hepatic fibrosis with sinusoidal capillarization in the early stage of non-alcoholic steatohepatitis in mice2022

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[Journal Article] A comparative analysis of hepatic pathological phenotypes in C57BL/6J and C57BL/6N mouse strains in non-alcoholic steatohepatitis models.2019

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[Journal Article] ASB14780, an Orally Active Inhibitor of Group IVA Phospholipase A2, Is a Pharmacotherapeutic Candidate for Nonalcoholic Fatty Liver Disease.2016

Akiba Satoshi 秋葉聡

秋葉聡アキバサトシ

AKIBA Satoshi 秋葉聡