KUROSAKI Hiromasa 黒崎博雅

Researcher Number	70234599
Affiliation (Current)	2022: 金城学院大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2015 – 2021: 金城学院大学, 薬学部, 教授 2014: 熊本大学, 大学院生命科学研究部(薬), 准教授 2013: 熊本大学, 大学院生命科学研究部, 准教授 2012: 熊本大学, 生命科学研究部, 准教授 2009 – 2011: Kumamoto University, 大学院・生命科学研究部, 准教授 … More
Review Section/Research Field	Principal Investigator Drug development chemistry / Chemical pharmacy / Environmental pharmacy / Physical pharmacy / Physical pharmacy / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related Except Principal Investigator Biological Sciences / 無機・錯塩・放射化学 / Inorganic chemistry / 医薬分子機能学 … More
Keywords	Principal Investigator 感染症 / 阻害剤 / 抗生物質 / 鉄錯体 / β-ラクタム剤 / ラクタマーゼ / ラクタム剤 / 加水分解酵素 / 過酸化水素 / 酸化反応 … More Except Principal Investigator X線結晶構造解析 / 速度論的解析 / NMR / dehydrogenation / 鉄錯体 / DNA / iron complex / 薬剤耐性菌 / メタロβ-ラクタマーゼ / PCR / 多剤耐性菌 / 遺伝子組み換え酵素 / 酵素 / 熱力学的解析 / 核酸認識 / インテグロン / 鉄(II)錯体 / 白金(II)錯体 / 芳香族配位子 / 脱水素反応 / 疎水性相互作用 / コバルト(III)錯体 / N-ベンジルエチレンジアミン / 配位原子 / アルキルペンダント / 金属錯体 / Fe complexes / cobalt(III)complexes / platinum(II) complexes / hydrophobic interaction / X-ray crystallography / alkyl pendant ligand / 脱水素 / ポリアミン / ブレオマイシン / ニトリル / C-C結合生成 / ヒドロペルオキシド / 酸化 / 炭素-炭素結合 / 1,3-ジイミン / polyamine / bleomycin / nitrile / C-C bond fomation / hydroperoxide / DAN切断 / 光学活性 / 電子スペクトル / 白金錯体 / CDスペクトル / DNA切断 / 過酸化水素 / 酸化反応 / ESR / EPR / CD / 電気化学 / DNA cleavage / optical active / electronic spectra / platinum complex / CD spectra / β-ラクタム加水分解 / 部位特異的変位酵素 / Co(II)置換酵素 / 可視吸収スペクトル / メタロ-β-ラクタマーゼ / 部位特異的変異酵素 / drug-resistant microorganism / metallo β-lactamase / hydrolysis of β-lactams / site-directed mutated enzyme / Co(II)-substituted enzymes / crystal structure analysis by X-ray diffraction / UV-vis spectrum / 加水分解酵素 / β-ラクタム剤 / 基質認識機構 / 阻害剤開発 / 部位特異的変異法 / hydrolase / β-lactam antibiotics / substrate-recognition mechanism / inhibitor / site-directed mutagenesis / x-ray crystallography / kinetics / カルバペネマーゼ / 既承認薬 / ハイスループット / ニトロセフィン / 阻害剤 / 阻害薬 Less

細菌性薬剤耐性タンパク質を標的としたデュアルターゲット型治療薬の開発研究
- Principal Investigator
  
  和知野純一
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Nagoya University
結晶構造に基づいたβ-ラクタム剤分解酵素メタロ-β-ラクタマーゼ阻害剤の分子設計Principal Investigator
- Principal Investigator
  
  黒崎博雅
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Kinjo Gakuin University
カルバペネム抗菌薬をも不活化するメタロ-β-ラクタマーゼの阻害剤・検出剤の合成Principal Investigator
- Principal Investigator
  
  黒崎博雅
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kinjo Gakuin University
Screening for carbapenemase inhibitors among approved drug compounds
- Principal Investigator
  
  Arakawa Yoshichika
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Infectious disease medicine
- Research Institution
  Nagoya University
Development of inhibitors based on the molecular structure and mechanism of substrate hydrolysis by metallo-beta-lactamasesPrincipal Investigator
- Principal Investigator
  
  KUROSAKI Hiromasa
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kinjo Gakuin University
  Kumamoto University
Development of fluorescent probes for metallo-beta-lactamase-producing Gram-negative bacteriaPrincipal Investigator
- Principal Investigator
  
  KUROSAKI Hiromasa
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Environmental pharmacy
- Research Institution
  Kumamoto University
Development of irreversible inhibitors forβ-lactam inactived enzyme, metallo-β-lactamasePrincipal Investigator
- Principal Investigator
  
  KUROSAKI Hiromasa
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kumamoto University
細菌の多剤耐性化に関与するインテグラーゼの結晶構造と基質-酵素相互作用の解析
- Principal Investigator
  
  YAMAGUCHI Yoshihiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
Structure-based Design of Selective metallo-β-lactamasePrincipal Investigator
- Principal Investigator
  
  KUROSAKI Hiromasa
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kumamoto University
Metallo-β-lactamase : Structural basis for substrate-specificity and rational design of the inhibitors
- Principal Investigator
  
  YAMAGUCHI Yoshihiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
Development of functional molecules capable of recognizing and cleaving the bulge structure in DNA by using an optical active dinuclear iron complexPrincipal Investigator
- Principal Investigator
  
  KUROSAKI Hiromasa
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
Sequence specific double-strand DNA cleavage by an optical active dinuclear iron complex and application for artificial restriction enzymePrincipal Investigator
- Principal Investigator
  
  KUROSAKI Hiromasa
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
Interaction of novel dinuclear platinum and iron complexes with double strand DNA
- Principal Investigator
  
  GOTO Masafumi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
Preparation of site-directed mutated metallo β-lactamase produced from a microorganism resistant for β-lactams and mechanism of hydrolysis for β-lactams by wild-type and mutated enzymes
- Principal Investigator
  
  MORI Hiromasa
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
複核鉄-ヒドロペルオキシド鉄錯体による二本鎖DNA同時切断Principal Investigator
- Principal Investigator
  
  黒崎博雅
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kumamoto University
Control of Reactivies of Mononuclear Iron Complexes by Design of Their Ligands
- Principal Investigator
  
  GOTO Masafumi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Inorganic chemistry
- Research Institution
  Kumamoto University
Stereochemistry of alkyl pendant ligands coordinated to metal complexes and its effect on reactivity
- Principal Investigator
  
  GOTO Masafumi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  無機・錯塩・放射化学
- Research Institution
  Kumamoto University

All 2019 2013 2012 2011 2010 2009 2005 2004

All Journal Article Presentation

[Journal Article] A demetallation method for IMP-1 metallo-β-lactamase that restored enzymatic activity upon addition of metal ion(s)2011
- Author(s)
  Yoshihiro Yamaguchi, Shijia Ding, Emi Murakami, Kayo Imamura, Sachiko Fuchigami, Ryo Hashiguchi, Katsuhide Yutani, Hiromasa Mori, Shinnichiro Suzuki, Yoshichika Arakawa, Hiromasa Kurosaki
- Journal Title
  
  ChemBioChem
  
  Volume: 12(13) Pages: 1979-1983
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590116
[Journal Article] A Demetallation Method for IMP-1 Metallo-ss-Lactamase with Restored Enzymatic Activity Upon Addition of Metal Ion(s)2011
- Author(s)
  Yamaguchi Y, Ding S, Murakami E, Imamura K, Fuchigami S, Hashiguchi R, Yutani K, Mori H, Suzuki S, Arakawa Y, Kurosaki H
- Journal Title
  
  ChemBioChem
  
  Volume: 12 Pages: 1979-1983
- DOI
  10.1002/cbic.201100342
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590116, KAKENHI-PROJECT-22570166
[Journal Article] Metal preference of Zn(II) and Co(II) for the dinuclear metal binding site of IMP-1 metallo-β-lactamase and spectroscopic properties of Co(II)-substituted IMP-1 with mercaptoacetic acid2011
- Author(s)
  Yamaguchi Y, Imamura K, Sasao A, Murakami E, Arakawa Y, Kurosaki H
- Journal Title
  
  Med.Chem.Commun.
  
  Volume: 2 Pages: 720-725
- DOI
  10.1039/c1md00062d
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590116
[Journal Article] Metal preference of Zn(II) and Co(II) for the dinuclear metal binding site of IMP-1 metallo-β-lactamase and spectroscopic properties of Co(II)-substituted IMP-1 with mercaptoacetic acid2011
- Author(s)
  Yoshihiro Yamaguchi, Kayo Imamura, Ako Sasao, Emi Murakami, Yoshichika Arakawa, Hiromasa Kurosaki
- Journal Title
  
  Med. Chem. Commun
  
  Volume: 2(8) Pages: 720-725
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590116
[Journal Article] Synthesis and spectroscopic properties of a nickel(II) complex with a chiral N,N,N-tri(2-pyridylmethyl)-S-2-(aminomethyl) piperidine=S-P3pipda2005
- Author(s)
  Hiromasa Kurosaki
- Journal Title
  
  Inorg.Chem.Commun. 8
  
  Pages: 437-440
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590031
[Journal Article] Synthesis and spectroscopic properties of a nickel(II) complex with achiral N,N,N'-tri(2-pyridylmethyl)-S-2-(aminomethyl)piperidine = S-P3pipda2005
- Author(s)
  Hiromasa Kurosaki
- Journal Title
  
  Inorg.Chem.Commun. 8
  
  Pages: 437-440
- Data Source
  KAKENHI-PROJECT-16590031
[Journal Article] Mechanism of formation of iron(II) complexes with pentadentate ligands via C-Cbond formation between trans-[Fe(2,4-bis(2-pyridylmethylimino)pentane(MeCN)_2][ClO_4]_2・MeCN and various nitriles2005
- Author(s)
  Hiromasa Kurosaki
- Journal Title
  
  Dalton Trans.
  
  Pages: 1086-1092
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590031
[Journal Article] Mechanism of formation of iron(II) complexes with pentadentate ligands via C-C bond formation between trans-[Fe(2,4-bis(2-pyridyl methylimino)pentane(MeCN)_2][ClO_4]_2 MeCN and various nitriles2005
- Author(s)
  Hiromasa Kurosaki
- Journal Title
  
  Dalton Trans.
  
  Pages: 1086-1092
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590031
[Journal Article] Synthesis and spectroscopic properties of a nickel(II) complex with a chiral N,N,N'-tri(2-pyridylmethyl)-S-2-(aminomethyl)piperidine = S-P3pipda2005
- Author(s)
  Hiromasa Kurosaki
- Journal Title
  
  Inorg. Chem. Commun. 8
  
  Pages: 437-440
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590031
[Journal Article] Mechanism of formation of iron(II) complexes with pentadentate ligands via C-C bond formation between trans-[Fe(2,4-bis(2-pyridylmethylimino)pentane(MeCN)_2][ClO_4]_2・MeCN and various nitriles2005
- Author(s)
  Hiromasa Kurosaki
- Journal Title
  
  Dalton Trans.
  
  Pages: 1086-1092
- Data Source
  KAKENHI-PROJECT-16590031
[Journal Article] Irreversible inhibition of metallo-β-lactamase (IMP-1) by 3-(3-mercaptopropionylsulfanyl)propionic acid pentafluorophenyl ester2005
- Author(s)
  Hiromasa Kurosaki
- Journal Title
  
  Angewandte Chemie International Edition 44
  
  Pages: 3861-3864
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390017
[Journal Article] Synthesis, Characterization, and crystal structure of the copper(II) complex of the optical active polypyridylmethylamine ligand : N,N,N-tris(2-pyridylmethyl)-S-2-(aminomethyl)piperidine = S-P3pida2004
- Author(s)
  Hiromasa Kurosaki
- Journal Title
  
  Inorg.Chem.Commun. 7
  
  Pages: 1229-1232
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590031
[Journal Article] Synthesis, Characterization, and crystal structure of the copper(II) complex of the optical active polypyridylmethylamine ligand : N,N,N'-tris(2-pyridylmethyl)-S-2-(aminomethyl)piperidine = S-P3pida2004
- Author(s)
  Hiromasa Kurosaki
- Journal Title
  
  Inorg.Chem.Commun. 7
  
  Pages: 1229-1232
- Data Source
  KAKENHI-PROJECT-16590031
[Journal Article] Synthesis, Characterization, and crystal structure of the copper(II) complex of theoptical active polypyridylmethylamine ligand : N,N,N'-tris(2-pyridylmethyl)-S-2-(aminomethyl)piperidine = S-P3pida2004
- Author(s)
  Hiromasa Kurosaki
- Journal Title
  
  Inorg. Chem. Commun. 7
  
  Pages: 1229-1232
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590031
[Presentation] メタロ-β-ラクタマーゼに対する3-ホルミルクロモン誘導体の阻害効果2019
- Author(s)
  筑紫奈美、泉昂季、汪若愚、石川吉伸、和知野純一、荒川宜親、黒崎博雅、山口佳宏
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-17K08376
[Presentation] UPLC/MSによる16S rRNA メチル基転移酵素によってメチル化されたグアノシン検出法の開発2019
- Author(s)
  玉寄裕也、山田聖、石井亮太郎、北村祐介、井原俊博、和知野純一、荒川宣親、黒崎博雅、山口佳宏
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-17K08376
[Presentation] メタロ-β-ラクタマーゼ(KHM-1)のセフェム系β-ラクタム剤に対する高効率触媒機構の解明2019
- Author(s)
  上之薗優也、伊東理生、藤田美歌子、藤間祥子、清水伸隆、山縣ゆり子、切替照雄、黒崎博雅、山口佳宏
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-17K08376
[Presentation] 亜鉛型βラクタム剤分解酵素のアミノ酸一変異による構造およびZn結合能への影響2019
- Author(s)
  俵紗季子、松瀬奈月、伊東理生、藤間祥子、山縣ゆり子、和知野純一、荒川宜親、黒崎博雅、山口佳宏
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-17K08376
[Presentation] Development of fluorescent probes for metallo-β-lactamase-producing Gram-negative bacteria2013
- Author(s)
  Hiromasa Kurosaki, Yoshihiro Yamaguchi
- Organizer
  28th International Congress of Chemotherapy and Infection
- Place of Presentation
  Pacifico Yokohama, Yokohama
- Data Source
  KAKENHI-PROJECT-24659054
[Presentation] Development of fluorescent probes for metallo-beta-lactamase-producing Gram-negative bacteria2013
- Author(s)
  Hiromasa Kurosaki, Yoshihiro Yamaguchi
- Organizer
  28th International Congress of Chemotherapy and Infection
- Place of Presentation
  パシフィコ横浜(横浜市西区)
- Data Source
  KAKENHI-PROJECT-24659054
[Presentation] メタロ-β-ラクタマーゼ活性阻害におけるメルカプトカルボン酸の至適炭素鎖長の決定と加水分解反応に及ぼすアニオンの影響2012
- Author(s)
  黒崎博雅、山口佳宏、荒川宜親
- Organizer
  第41回薬剤耐性菌研究会
- Place of Presentation
  岐阜県下呂市望川館コンベンションホール
- Data Source
  KAKENHI-PROJECT-24659054
[Presentation] メタロ-β-ラクタマーゼ活性阻害におけるメルカプトカルボン酸の至敵炭素鎖長の決定と加水分解反応に及ぼすアニオンの影響2012
- Author(s)
  黒崎博雅、山口佳宏、荒川宜親
- Organizer
  第41回薬剤耐性菌研究会
- Place of Presentation
  望川館コンベンションホール, 岐阜県下呂市湯之島
- Data Source
  KAKENHI-PROJECT-24659054
[Presentation] etection of metallo-β-lactamase producing bacteria by fluorescent probe having dansyl and thiol groups2010
- Author(s)
  Koki MATSUDA, Yoshihiro YAMAGUCHI, Junzo HIROSE, Yoshichika ARAKAWA, Hiromasa KUROSAKI
- Organizer
  第20回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  徳島文理大学(徳島)
- Data Source
  KAKENHI-PROJECT-21590116
[Presentation] Detection of metallo-β-lactamase producing bacteria by fluoresent probe having dansyl and thiol groups2010
- Author(s)
  Kouki Matsuda, Yoshihiro Yamaguchi, Junzo Hirose, Yoshichika Arakawa, Hiromasa Kurosaki
- Organizer
  第20回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  徳島文理大学(徳島)
- Year and Date
  2010-06-25
- Data Source
  KAKENHI-PROJECT-21590116
[Presentation] 薬剤耐性菌が産生するメタロ-β-ラクタマーゼの蛍光検出法の開発:ダンシル基とチオール基をもつ蛍光剤のメタロ-β-ラクタマーゼIMP-1, VIM-2, IMD-7に対する蛍光特性と速度論的解析2009
- Author(s)
  松田幸喜, 山口佳宏, 廣瀬順造, 荒川宜親, 黒崎博雅
- Organizer
  第38回薬剤耐性菌研究会
- Place of Presentation
  森秋旅館(群馬県)
- Year and Date
  2009-11-20
- Data Source
  KAKENHI-PROJECT-21590116
[Presentation] 薬剤耐性菌が産生するメタロ-β-ラクタマーゼの蛍光検出法の開発:ダンシルとチオール基を持つ蛍光剤のメタロ-β-ラクタマーゼIMP-1, VIM-2, IND-7に対する蛍光特性と速度論解析2009
- Author(s)
  松田幸喜、山口佳宏、廣瀬順三、荒川宜親、黒崎博雅
- Organizer
  第38回薬剤耐性菌研究会
- Place of Presentation
  森秋旅館(群馬)
- Year and Date
  2009-11-20
- Data Source
  KAKENHI-PROJECT-21590116

1. YAMAGUCHI Yoshihiro (10363524)

# of Collaborated Projects: 6 results

# of Collaborated Products: 12 results
2. GOTO Masafumi (50080180)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. MORI Hiromasa (40040315)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. ARAKAWA Yoshichika (10212622)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
5. WACHINO Jun-ichi (00535651)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. KIMURA Kouji (50425675)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 藤田美歌子 (00322256)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 福石信之 (70248326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 加藤紘一 (80814821)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. JIN Wanchun

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YOKOYAMA Satoru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KANECHI Leo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KANAYAMA Takato

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Kumar Anupuriya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KUROSAKI Hiromasa 黒崎 博雅

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

結晶構造に基づいたβ-ラクタム剤分解酵素メタロ-β-ラクタマーゼ阻害剤の分子設計Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

カルバペネム抗菌薬をも不活化するメタロ-β-ラクタマーゼの阻害剤・検出剤の合成Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of inhibitors based on the molecular structure and mechanism of substrate hydrolysis by metallo-beta-lactamasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of fluorescent probes for metallo-beta-lactamase-producing Gram-negative bacteriaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of irreversible inhibitors forβ-lactam inactived enzyme, metallo-β-lactamasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structure-based Design of Selective metallo-β-lactamasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of functional molecules capable of recognizing and cleaving the bulge structure in DNA by using an optical active dinuclear iron complexPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Sequence specific double-strand DNA cleavage by an optical active dinuclear iron complex and application for artificial restriction enzymePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

KUROSAKI Hiromasa 黒崎博雅