KUROSAKI Hiromasa 黒崎博雅

Researcher Number	70234599
Affiliation (Current)	2025: 金城学院大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2015 – 2024: 金城学院大学, 薬学部, 教授 2014: 熊本大学, 大学院生命科学研究部(薬), 准教授 2013: 熊本大学, 大学院生命科学研究部, 准教授 2012: 熊本大学, 生命科学研究部, 准教授 2009 – 2011: Kumamoto University, 大学院・生命科学研究部, 准教授 … More 2007 – 2008: Kumamoto University, Faculty of Medicinal and Pharmaceutical Sciences, Associate Professor 2006: 熊本大学, 大学院医学薬学研究部, 助教授 2003 – 2005: Kumamoto University, Faculty of Medicinal and Pharmaceutical Sciences, Associate Professor, 大学院・医学薬学研究部, 助教授 1999 – 2002: 熊本大学, 薬学部, 助手 1996 – 1997: 熊本大学, 薬学部, 助手 1992 – 1993: 熊本大学, 薬学部, 助手 Less
Review Section/Research Field	Principal Investigator Drug development chemistry / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Physical pharmacy / Physical pharmacy / Environmental pharmacy / Chemical pharmacy Except Principal Investigator Basic Section 54030:Infectious disease medicine-related / Infectious disease medicine / Physical pharmacy / Physical pharmacy … More / 医薬分子機能学 / Inorganic chemistry / 無機・錯塩・放射化学 / Biological Sciences Less
Keywords	Principal Investigator 感染症 / 抗生物質 / 阻害剤 / ラクタマーゼ / β-ラクタム剤 / 加水分解酵素 / ラクタム剤 / 細菌感染症 / βーラクタム剤 / 金属酵素 … More / 鉄錯体 / 亜鉛酵素 / DNA / optical active / iron complex / 電子スペクトル / 光学活性 / X線結晶構造解析 / 酵素 / 薬学 / 薬剤耐性菌 / ESR / 酸化反応 / 過酸化水素 / 蛍光検出剤 / メタローβーラクタマーゼ / βーラクタム / βーラクタマーゼ / ストップトフロー法 / メタロ-β-ラクタマーゼ / 薬剤耐性 / 蛍光剤 / β-タクタム剤 / lactamase / inhibitor / infectious disease / β-lactam / β-ラタタム剤 / restriction enzyme / 錯体 / 制限酵素 / CD spectra / electronic spectra / DNA cleavage / CDスペクトル / COスペクトル / DAN切断 / Ｘ線結晶構造解析 / β‐ラクタム剤 / 細菌検査 / 蛍光検出 / 院内感染 / 細菌 / 耐性菌 / 医薬分子設計 / 5座配位子 / 置換基効果 / 鉄(III)-ヒドロペルオキシド / pUC19プラスミドDNA / EPR / DNA切断 … More Except Principal Investigator X線結晶構造解析 / メタロβ-ラクタマーゼ / 阻害剤 / カルバペネマーゼ / メタロ-β-ラクタマーゼ / PCR / 薬剤耐性菌 / iron complex / DNA / 鉄錯体 / dehydrogenation / NMR / 速度論的解析 / β-ラクタマーゼ / 金属親和性天然物 / 腸内細菌目細菌 / 競合阻害 / カルバペネム / 化合物合成 / 阻害薬 / ニトロセフィン / ハイスループット / 既承認薬 / kinetics / x-ray crystallography / site-directed mutagenesis / inhibitor / substrate-recognition mechanism / β-lactam antibiotics / hydrolase / 部位特異的変異法 / 阻害剤開発 / 基質認識機構 / β-ラクタム剤 / 加水分解酵素 / UV-vis spectrum / crystal structure analysis by X-ray diffraction / Co(II)-substituted enzymes / site-directed mutated enzyme / hydrolysis of β-lactams / metallo β-lactamase / drug-resistant microorganism / 部位特異的変異酵素 / 可視吸収スペクトル / Co(II)置換酵素 / 部位特異的変位酵素 / β-ラクタム加水分解 / CD spectra / platinum complex / electronic spectra / optical active / DNA cleavage / 電気化学 / CD / EPR / ESR / 酸化反応 / 過酸化水素 / DNA切断 / CDスペクトル / 白金錯体 / 電子スペクトル / 光学活性 / DAN切断 / hydroperoxide / C-C bond fomation / nitrile / bleomycin / polyamine / 1,3-ジイミン / 炭素-炭素結合 / 酸化 / ヒドロペルオキシド / C-C結合生成 / ニトリル / ブレオマイシン / ポリアミン / 脱水素 / alkyl pendant ligand / X-ray crystallography / hydrophobic interaction / platinum(II) complexes / cobalt(III)complexes / Fe complexes / 金属錯体 / アルキルペンダント / 配位原子 / N-ベンジルエチレンジアミン / コバルト(III)錯体 / 疎水性相互作用 / 脱水素反応 / 芳香族配位子 / 白金(II)錯体 / 鉄(II)錯体 / インテグロン / 核酸認識 / 熱力学的解析 / 酵素 / 遺伝子組み換え酵素 / 多剤耐性菌 Less

金属親和性天然物のスリム化と再構築による薬剤耐性阻害剤の開発
- Principal Investigator
  
  和知野純一
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Fujita Health University
細菌性薬剤耐性タンパク質を標的としたデュアルターゲット型治療薬の開発研究
- Principal Investigator
  
  和知野純一
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Shubun University
結晶構造に基づいたβ-ラクタム剤分解酵素メタロ-β-ラクタマーゼ阻害剤の分子設計Principal Investigator
- Principal Investigator
  
  黒崎博雅
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Kinjo Gakuin University
Synthesis of inhibitors and fluorescence reagents for metallo-beta-lactamasesPrincipal Investigator
- Principal Investigator
  
  Kurosaki Hiromasa
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kinjo Gakuin University
Screening for carbapenemase inhibitors among approved drug compounds
- Principal Investigator
  
  Arakawa Yoshichika
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Infectious disease medicine
- Research Institution
  Nagoya University
Development of inhibitors based on the molecular structure and mechanism of substrate hydrolysis by metallo-beta-lactamasesPrincipal Investigator
- Principal Investigator
  
  KUROSAKI Hiromasa
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kinjo Gakuin University
  Kumamoto University
Development of fluorescent probes for metallo-beta-lactamase-producing Gram-negative bacteriaPrincipal Investigator
- Principal Investigator
  
  KUROSAKI Hiromasa
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Environmental pharmacy
- Research Institution
  Kumamoto University
Development of irreversible inhibitors forβ-lactam inactived enzyme, metallo-β-lactamasePrincipal Investigator
- Principal Investigator
  
  KUROSAKI Hiromasa
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kumamoto University
細菌の多剤耐性化に関与するインテグラーゼの結晶構造と基質-酵素相互作用の解析
- Principal Investigator
  
  YAMAGUCHI Yoshihiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
Structure-based Design of Selective metallo-β-lactamasePrincipal Investigator
- Principal Investigator
  
  KUROSAKI Hiromasa
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kumamoto University
Metallo-β-lactamase : Structural basis for substrate-specificity and rational design of the inhibitors
- Principal Investigator
  
  YAMAGUCHI Yoshihiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
Development of functional molecules capable of recognizing and cleaving the bulge structure in DNA by using an optical active dinuclear iron complexPrincipal Investigator
- Principal Investigator
  
  KUROSAKI Hiromasa
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
Sequence specific double-strand DNA cleavage by an optical active dinuclear iron complex and application for artificial restriction enzymePrincipal Investigator
- Principal Investigator
  
  KUROSAKI Hiromasa
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
Interaction of novel dinuclear platinum and iron complexes with double strand DNA
- Principal Investigator
  
  GOTO Masafumi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
Preparation of site-directed mutated metallo β-lactamase produced from a microorganism resistant for β-lactams and mechanism of hydrolysis for β-lactams by wild-type and mutated enzymes
- Principal Investigator
  
  MORI Hiromasa
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
複核鉄-ヒドロペルオキシド鉄錯体による二本鎖DNA同時切断Principal Investigator
- Principal Investigator
  
  黒崎博雅
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kumamoto University
Control of Reactivies of Mononuclear Iron Complexes by Design of Their Ligands
- Principal Investigator
  
  GOTO Masafumi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Inorganic chemistry
- Research Institution
  Kumamoto University
Stereochemistry of alkyl pendant ligands coordinated to metal complexes and its effect on reactivity
- Principal Investigator
  
  GOTO Masafumi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  無機・錯塩・放射化学
- Research Institution
  Kumamoto University

All 2023 2022 2021 2019 2013 2012 2011 2010 2009 2005 2004

All Journal Article Presentation

[Journal Article] Artificial helix supramolecule by doubly p-xylyl bridged bis(ZnII-cyclen) (cyclen = 1,4,7,10-tetraazacyclododecane)2023
- Author(s)
  Ichimaru Yoshimi、Kato Koichi、Sugiura Kirara、Isomura Risa、Fujioka Haruto、Koike Tohru、Fujii-Kishida Sayuri、Kurihara Masaaki、Yamaguchi Yoshihiro、Jin Wanchun、Imai Masanori、Kurosaki Hiromasa
- Journal Title
  
  Inorganic Chemistry Communications
  
  Volume: 153 Pages: 110782-110782
- DOI
  10.1016/j.inoche.2023.110782
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06500, KAKENHI-PROJECT-17K08376, KAKENHI-PROJECT-21K15244
[Journal Article] Difference in the Inhibitory Effect of Thiol Compounds and Demetallation Rates from the Zn(II) Active Site of Metallo-β-lactamases (IMP-1 and IMP-6) Associated with a Single Amino Acid Substitution2022
- Author(s)
  Yamaguchi Yoshihiro、Kato Koichi、Ichimaru Yoshimi、Uenosono Yuya、Tawara Sakiko、Ito Rio、Matsuse Natsuki、Wachino Jun-ichi、Toma-Fukai Sachiko、Jin Wanchun、Arakawa Yoshichika、Otsuka Masami、Fujita Mikako、Fukuishi Nobuyuki、Sugiura Kirara、Imai Masanori、Kurosaki Hiromasa
- Journal Title
  
  ACS Infectious Diseases
  
  Volume: 9 Issue: 1 Pages: 65-78
- DOI
  10.1021/acsinfecdis.2c00395
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06500, KAKENHI-PROJECT-21K15244, KAKENHI-PROJECT-21H02967, KAKENHI-PROJECT-17K08376
[Journal Article] Bis(nitrato-κO)(1,4,8,11-tetraazacyclotetradecane-κ4N)zinc(II) methanol monosolvate2022
- Author(s)
  Ichimaru Yoshimi、Kato Koichi、Kurihara Masaaki、Jin Wanchun、Koike Tohru、Kurosaki Hiromasa
- Journal Title
  
  IUCrData
  
  Volume: 7 Issue: 8 Pages: 220854-220863
- DOI
  10.1107/s2414314622008549
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06500, KAKENHI-PROJECT-21K15244, KAKENHI-PROJECT-17K08376, KAKENHI-PROJECT-20K06988
[Journal Article] Crystal Structures of Metallo-β-Lactamase (IMP-1) and Its D120E Mutant in Complexes with Citrate and the Inhibitory Effect of the Benzyl Group in Citrate Monobenzyl Ester2021
- Author(s)
  Yamaguchi Yoshihiro、Kato Koichi、Ichimaru Yoshimi、Jin Wanchun、Sakai Misa、Abe Miki、Wachino Jun-ichi、Arakawa Yoshichika、Miyagi Yukina、Imai Masanori、Fukuishi Nobuyuki、Yamagata Yuriko、Otsuka Masami、Fujita Mikako、Kurosaki Hiromasa
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 64 Issue: 14 Pages: 10019-10026
- DOI
  10.1021/acs.jmedchem.1c00308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02967, KAKENHI-PROJECT-17K08376
[Journal Article] Crystal Structure of Bis{1,3-bis[bis(pyridin-2-ylmethyl)amino]propan-2-olato-dizinc(II)}orthophosphate Tris(perchlorate) Octahydrate, [(Phos-tag)2-PO43−][ClO4−]3·8H2O2021
- Author(s)
 Ichimaru Yoshimi、Kato Koichi、Jin Wanchun、Sugiura Kirara、Kinoshita-Kikuta Emiko、KINOSHITA Eiji、Kurosaki Hiromasa、Koike Tohru
- Journal Title
 
 X-ray Structure Analysis Online
 
 Volume: 37 Issue: 0 Pages: 87-88
- DOI
 10.2116/xraystruct.37.87
- NAID
 130008127785
- ISSN
 1883-3578
- Year and Date
 2021-12-10
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-17K08376, KAKENHI-PROJECT-20K06988, KAKENHI-PROJECT-21K06455, KAKENHI-PROJECT-21K06500
[Journal Article] Characterization of the binding of adenosine-5’-monophosphate to a mu-type alkoxide-linked dinuclear zinc(II) complex in crystal and solution state.2021
- Author(s)
  Kinoshita-Kikuta, E., Ichimaru, Y., Yamano, Y., Kato, K., Kurosaki, H. Eiji Kinoshita, Koike, T.
- Journal Title
  
  Bull. Chem. Soc. Jpn.
  
  Volume: 94(11) Issue: 11 Pages: 2670-2677
- DOI
  10.1246/bcsj.20210280
- NAID
  130008137574
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07147, KAKENHI-PROJECT-20K06988, KAKENHI-PROJECT-21K06500
[Journal Article] A demetallation method for IMP-1 metallo-β-lactamase that restored enzymatic activity upon addition of metal ion(s)2011
- Author(s)
  Yoshihiro Yamaguchi, Shijia Ding, Emi Murakami, Kayo Imamura, Sachiko Fuchigami, Ryo Hashiguchi, Katsuhide Yutani, Hiromasa Mori, Shinnichiro Suzuki, Yoshichika Arakawa, Hiromasa Kurosaki
- Journal Title
  
  ChemBioChem
  
  Volume: 12(13) Pages: 1979-1983
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590116
[Journal Article] A demetallation method for IMP-1 metallo-ss-lactamase with restored enzymatic activity upon addition of metal ion(s)2011
- Author(s)
  Yamaguchi Y, Ding S, Murakami E, Imamura K, Fuchigami S, Hashiguchi R, Yutani K, Mori H, Suzuki S, Arakawa Y, Kurosaki H
- Journal Title
  
  ChemBioChem
  
  Volume: 12 Issue: 13 Pages: 1979-1983
- DOI
  10.1002/cbic.201100342
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590116, KAKENHI-PROJECT-22570166
[Journal Article] Metal preference of Zn(II) and Co(II) for the dinuclear metal binding site of IMP-1 metallo-β-lactamase and spectroscopic properties of Co(II)-substituted IMP-1 with mercaptoacetic acid2011
- Author(s)
  Yamaguchi Y, Imamura K, Sasao A, Murakami E, Arakawa Y, Kurosaki H
- Journal Title
  
  Med.Chem.Commun.
  
  Volume: 2 Issue: 8 Pages: 720-725
- DOI
  10.1039/c1md00062d
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590116
[Journal Article] Metal preference of Zn(II) and Co(II) for the dinuclear metal binding site of IMP-1 metallo-β-lactamase and spectroscopic properties of Co(II)-substituted IMP-1 with mercaptoacetic acid2011
- Author(s)
  Yoshihiro Yamaguchi, Kayo Imamura, Ako Sasao, Emi Murakami, Yoshichika Arakawa, Hiromasa Kurosaki
- Journal Title
  
  Med. Chem. Commun
  
  Volume: 2(8) Pages: 720-725
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590116
[Journal Article] Synthesis and spectroscopic properties of a nickel(II) complex with a chiral N,N,N-tri(2-pyridylmethyl)-S-2-(aminomethyl) piperidine=S-P3pipda2005
- Author(s)
  Hiromasa Kurosaki
- Journal Title
  
  Inorg.Chem.Commun. 8
  
  Pages: 437-440
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590031
[Journal Article] Synthesis and spectroscopic properties of a nickel(II) complex with achiral N,N,N'-tri(2-pyridylmethyl)-S-2-(aminomethyl)piperidine = S-P3pipda2005
- Author(s)
  Hiromasa Kurosaki
- Journal Title
  
  Inorg.Chem.Commun. 8
  
  Pages: 437-440
- Data Source
  KAKENHI-PROJECT-16590031
[Journal Article] Mechanism of formation of iron(II) complexes with pentadentate ligands via C-Cbond formation between trans-[Fe(2,4-bis(2-pyridylmethylimino)pentane(MeCN)_2][ClO_4]_2・MeCN and various nitriles2005
- Author(s)
  Hiromasa Kurosaki
- Journal Title
  
  Dalton Trans.
  
  Pages: 1086-1092
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590031
[Journal Article] Mechanism of formation of iron(II) complexes with pentadentate ligands via C-C bond formation between trans-[Fe(2,4-bis(2-pyridyl methylimino)pentane(MeCN)_2][ClO_4]_2 MeCN and various nitriles2005
- Author(s)
  Hiromasa Kurosaki
- Journal Title
  
  Dalton Trans.
  
  Pages: 1086-1092
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590031
[Journal Article] Synthesis and spectroscopic properties of a nickel(II) complex with a chiral N,N,N'-tri(2-pyridylmethyl)-S-2-(aminomethyl)piperidine = S-P3pipda2005
- Author(s)
  Hiromasa Kurosaki
- Journal Title
  
  Inorg. Chem. Commun. 8
  
  Pages: 437-440
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590031
[Journal Article] Mechanism of formation of iron(II) complexes with pentadentate ligands via C-C bond formation between trans-[Fe(2,4-bis(2-pyridylmethylimino)pentane(MeCN)_2][ClO_4]_2・MeCN and various nitriles2005
- Author(s)
  Hiromasa Kurosaki
- Journal Title
  
  Dalton Trans.
  
  Pages: 1086-1092
- Data Source
  KAKENHI-PROJECT-16590031
[Journal Article] Irreversible inhibition of metallo-β-lactamase (IMP-1) by 3-(3-mercaptopropionylsulfanyl)propionic acid pentafluorophenyl ester2005
- Author(s)
  Hiromasa Kurosaki
- Journal Title
  
  Angewandte Chemie International Edition 44
  
  Pages: 3861-3864
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390017
[Journal Article] Synthesis, Characterization, and crystal structure of the copper(II) complex of the optical active polypyridylmethylamine ligand : N,N,N-tris(2-pyridylmethyl)-S-2-(aminomethyl)piperidine = S-P3pida2004
- Author(s)
  Hiromasa Kurosaki
- Journal Title
  
  Inorg.Chem.Commun. 7
  
  Pages: 1229-1232
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590031
[Journal Article] Synthesis, Characterization, and crystal structure of the copper(II) complex of the optical active polypyridylmethylamine ligand : N,N,N'-tris(2-pyridylmethyl)-S-2-(aminomethyl)piperidine = S-P3pida2004
- Author(s)
  Hiromasa Kurosaki
- Journal Title
  
  Inorg.Chem.Commun. 7
  
  Pages: 1229-1232
- Data Source
  KAKENHI-PROJECT-16590031
[Journal Article] Synthesis, Characterization, and crystal structure of the copper(II) complex of theoptical active polypyridylmethylamine ligand : N,N,N'-tris(2-pyridylmethyl)-S-2-(aminomethyl)piperidine = S-P3pida2004
- Author(s)
  Hiromasa Kurosaki
- Journal Title
  
  Inorg. Chem. Commun. 7
  
  Pages: 1229-1232
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590031
[Presentation] メタロ-β-ラクタマーゼに対する3-ホルミルクロモン誘導体の阻害効果2019
- Author(s)
  筑紫奈美、泉昂季、汪若愚、石川吉伸、和知野純一、荒川宜親、黒崎博雅、山口佳宏
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-17K08376
[Presentation] UPLC/MSによる16S rRNA メチル基転移酵素によってメチル化されたグアノシン検出法の開発2019
- Author(s)
  玉寄裕也、山田聖、石井亮太郎、北村祐介、井原俊博、和知野純一、荒川宣親、黒崎博雅、山口佳宏
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-17K08376
[Presentation] メタロ-β-ラクタマーゼ(KHM-1)のセフェム系β-ラクタム剤に対する高効率触媒機構の解明2019
- Author(s)
  上之薗優也、伊東理生、藤田美歌子、藤間祥子、清水伸隆、山縣ゆり子、切替照雄、黒崎博雅、山口佳宏
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-17K08376
[Presentation] 亜鉛型βラクタム剤分解酵素のアミノ酸一変異による構造およびZn結合能への影響2019
- Author(s)
  俵紗季子、松瀬奈月、伊東理生、藤間祥子、山縣ゆり子、和知野純一、荒川宜親、黒崎博雅、山口佳宏
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-17K08376
[Presentation] Development of fluorescent probes for metallo-β-lactamase-producing Gram-negative bacteria2013
- Author(s)
  Hiromasa Kurosaki, Yoshihiro Yamaguchi
- Organizer
  28th International Congress of Chemotherapy and Infection
- Place of Presentation
  Pacifico Yokohama, Yokohama
- Data Source
  KAKENHI-PROJECT-24659054
[Presentation] Development of fluorescent probes for metallo-beta-lactamase-producing Gram-negative bacteria2013
- Author(s)
  Hiromasa Kurosaki, Yoshihiro Yamaguchi
- Organizer
  28th International Congress of Chemotherapy and Infection
- Place of Presentation
  パシフィコ横浜(横浜市西区)
- Data Source
  KAKENHI-PROJECT-24659054
[Presentation] メタロ-β-ラクタマーゼ活性阻害におけるメルカプトカルボン酸の至適炭素鎖長の決定と加水分解反応に及ぼすアニオンの影響2012
- Author(s)
  黒崎博雅、山口佳宏、荒川宜親
- Organizer
  第41回薬剤耐性菌研究会
- Place of Presentation
  岐阜県下呂市望川館コンベンションホール
- Data Source
  KAKENHI-PROJECT-24659054
[Presentation] メタロ-β-ラクタマーゼ活性阻害におけるメルカプトカルボン酸の至敵炭素鎖長の決定と加水分解反応に及ぼすアニオンの影響2012
- Author(s)
  黒崎博雅、山口佳宏、荒川宜親
- Organizer
  第41回薬剤耐性菌研究会
- Place of Presentation
  望川館コンベンションホール, 岐阜県下呂市湯之島
- Data Source
  KAKENHI-PROJECT-24659054
[Presentation] etection of metallo-β-lactamase producing bacteria by fluorescent probe having dansyl and thiol groups2010
- Author(s)
  Koki MATSUDA, Yoshihiro YAMAGUCHI, Junzo HIROSE, Yoshichika ARAKAWA, Hiromasa KUROSAKI
- Organizer
  第20回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  徳島文理大学(徳島)
- Data Source
  KAKENHI-PROJECT-21590116
[Presentation] Detection of metallo-β-lactamase producing bacteria by fluoresent probe having dansyl and thiol groups2010
- Author(s)
  Kouki Matsuda, Yoshihiro Yamaguchi, Junzo Hirose, Yoshichika Arakawa, Hiromasa Kurosaki
- Organizer
  第20回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  徳島文理大学(徳島)
- Year and Date
  2010-06-25
- Data Source
  KAKENHI-PROJECT-21590116
[Presentation] 薬剤耐性菌が産生するメタロ-β-ラクタマーゼの蛍光検出法の開発:ダンシル基とチオール基をもつ蛍光剤のメタロ-β-ラクタマーゼIMP-1, VIM-2, IMD-7に対する蛍光特性と速度論的解析2009
- Author(s)
  松田幸喜, 山口佳宏, 廣瀬順造, 荒川宜親, 黒崎博雅
- Organizer
  第38回薬剤耐性菌研究会
- Place of Presentation
  森秋旅館(群馬県)
- Year and Date
  2009-11-20
- Data Source
  KAKENHI-PROJECT-21590116
[Presentation] 薬剤耐性菌が産生するメタロ-β-ラクタマーゼの蛍光検出法の開発:ダンシルとチオール基を持つ蛍光剤のメタロ-β-ラクタマーゼIMP-1, VIM-2, IND-7に対する蛍光特性と速度論解析2009
- Author(s)
  松田幸喜、山口佳宏、廣瀬順三、荒川宜親、黒崎博雅
- Organizer
  第38回薬剤耐性菌研究会
- Place of Presentation
  森秋旅館(群馬)
- Year and Date
  2009-11-20
- Data Source
  KAKENHI-PROJECT-21590116

1. YAMAGUCHI Yoshihiro (10363524)

# of Collaborated Projects: 6 results

# of Collaborated Products: 12 results
2. GOTO Masafumi (50080180)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. MORI Hiromasa (40040315)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. WACHINO Jun-ichi (00535651)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
5. ARAKAWA Yoshichika (10212622)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
6. KIMURA Kouji (50425675)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 藤田美歌子 (00322256)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 福石信之 (70248326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 加藤紘一 (80814821)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. JIN Wanchun

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YOKOYAMA Satoru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KANECHI Leo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KANAYAMA Takato

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Kumar Anupuriya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 木下英司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KUROSAKI Hiromasa 黒崎 博雅

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結晶構造に基づいたβ-ラクタム剤分解酵素メタロ-β-ラクタマーゼ阻害剤の分子設計Principal Investigator

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Synthesis of inhibitors and fluorescence reagents for metallo-beta-lactamasesPrincipal Investigator

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Development of inhibitors based on the molecular structure and mechanism of substrate hydrolysis by metallo-beta-lactamasesPrincipal Investigator

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Development of fluorescent probes for metallo-beta-lactamase-producing Gram-negative bacteriaPrincipal Investigator

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Development of irreversible inhibitors forβ-lactam inactived enzyme, metallo-β-lactamasePrincipal Investigator

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Structure-based Design of Selective metallo-β-lactamasePrincipal Investigator

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Development of functional molecules capable of recognizing and cleaving the bulge structure in DNA by using an optical active dinuclear iron complexPrincipal Investigator

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Sequence specific double-strand DNA cleavage by an optical active dinuclear iron complex and application for artificial restriction enzymePrincipal Investigator

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KUROSAKI Hiromasa 黒崎博雅

[Journal Article] Crystal Structure of Bis{1,3-bis[bis(pyridin-2-ylmethyl)amino]propan-2-olato-dizinc(II)}orthophosphate Tris(perchlorate) Octahydrate, [(Phos-tag)<sub>2</sub>-PO<sub>4</sub><sup>3−</sup>][ClO<sub>4</sub><sup>−</sup>]<sub>3</sub>·8H<sub>2</sub>O2021