WAKUI Hideki 涌井秀樹

… Alternative Names

涌井秀樹ワクイヒデキ

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Researcher Number	70240463
Other IDs
Affiliation (based on the past Project Information) *help	2019 – 2021: 秋田大学, 理工学研究科, 教授 2016 – 2017: 秋田大学, 理工学研究科, 教授 2015: 秋田大学, 工学(系)研究科(研究院), 教授 2011: 秋田大学, 医学研究科, 准教授 2009 – 2011: Akita University, 大学院・医学系研究科, 准教授 … More 2007 – 2008: Akita University, School of Medicine, Associate Professor 2005 – 2006: 秋田大学, 医学部, 助教授 1999 – 2004: 秋田大学, 医学部, 講師 1993: 秋田大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Kidney internal medicine / Kidney internal medicine / Collagenous pathology/Allergology Except Principal Investigator Basic Section 53040:Nephrology-related / Kidney internal medicine / Kidney internal medicine
Keywords	Principal Investigator 免疫抑制剤 / HSP60 / RIP140 / 蛋白尿 / アクチニン / 糸球体濾過バリアー / 内科 / 蛋白質 / 生体分子 / シグナル伝達 … More / 細胞・組織 / 薬剤アフィニティーカラム / 薬剤標的蛋白質 / 血液・免疫組織 / 免疫調節剤 / 温故知新創薬 / 臨床応用 / 新規薬理作用 / 薬剤結合蛋白質（標的蛋白質候補） / 動物臓器 / ヒト血液 / 薬剤アフィニティークロマトグラフィー / 免疫抑制剤・免疫調節剤 / two-hybrid system / humanin / focal segmental glomerulosclerosis / puromycin aminonucleoside / nephrotic syndrome / actinin-4 / filtration barrier / glomerulus / ネフローゼ惹起物質 / two-hybrid法 / ヒューマニン / 巣状分節状糸球体硬化症 / ピューロマイシンアミノヌクレオシド / ネフローゼ症候群 / アクチニン-4 / 濾過バリアー / 糸球体 / 14-3-3 proteins / Molecular chaperone / Mizonbine / Immunosuppressant / HIT蛋白 / 14-3-3蛋白 / SHP60 / 分子シャペロン / ミゾリビン / 蛋白尿・ネフローゼ症候群 / アクチニン4 / HSP90 / HSP73 / 熱ショック蛋白質 / 腎毒性 / FK506結合蛋白質 / FK506 … More Except Principal Investigator TRAIL / SLE / HSPC159 / chemokine ligand 13 / HSP105 / HSP60 / HSP73 / 自己抗体 / 続発性 / 特発性 / 糸球体 / 抗原 / 質量分析 / Bucillamine腎症 / PLA2R陰性 / PLA2R陽性 / 膜性腎症 / MPO-ANCA-associated glomeruloneohritis / cDNA microarray / SAGE / MCNS / TNFSF-10 / 寛解・再発 / S100A12 / 末梢単核球 / 高発現遺伝子 / MPO-ANCA関連糸球体腎炎 / cDNA microarray法 / SAGE法 / 微小変化型ネフローゼ症候群 / dehydration / renal toxicity / chaperon / gentamicin / heat shock proteins / 浸透圧 / 耐性 / 遺伝子導入 / シャペロン / HSP90 / HSP72 / 脱水 / 腎毒性 / シャペロン活性 / GM / 熱ショック蛋白質 Less

The study to identify novel pathogenesis and autoantigens in patients with membranous nephropathy
- Principal Investigator
  
  Komatsuda Atsushi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Akita University
Identification of novel proteins that bind to various immunosuppressive / immunomodulatory drugs and clinical implications in the immune systemPrincipal Investigator
- Principal Investigator
  
  WAKUI Hideki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Akita University
Molecular interaction that is important for the maintenance of glomerular filtration barrier and its significance in the signal transduction systemPrincipal Investigator
- Principal Investigator
  
  WAKUI Hideki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Akita University
Signaling factors that interact with actinin-4, a component molecule of the glomerular filtration barrierPrincipal Investigator
- Principal Investigator
  
  WAKUI Hideki
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Akita University
Gene expression profiling of peripheral blood mononuclear cells from patients with minimal change nephrotic syndrome
- Principal Investigator
  
  KOMATSUDA Atsushi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Akita University
Interaction between glomerular filtration barrier component actinin-4 and nephrosis-inducing factorsPrincipal Investigator
- Principal Investigator
  
  WAKUI Hideki
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Akita University
Analysis of protective roles for renal injury by heat shock proteins treansfected with HSP genes
- Principal Investigator
  
  KOMATSUDA Atsushi
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Akita University
A study on an immunosuppressant mizoribine-binding renal proteins (esp. molecular chaperones)Principal Investigator
- Principal Investigator
  
  WAKUI Hideki
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Akita University
腎の免疫抑制剤FK506結合蛋白質の精製とFK506腎毒性発現に関する研究Principal Investigator
- Principal Investigator
  
  涌井秀樹
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Akita University

All 2021 2017 2016 2015 2012 2011 2010 2009 2007 2006 2004 2003 2002 Other

All Journal Article Presentation Book

[Book] 分子腎臓病学、微小変化型ネフローゼ症候群2006
- Author(s)
  涌井秀樹, 小松田敦
- Total Pages
  4
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-17590817
[Journal Article] Hydroxychloroquine binding to cytoplasmic domain of Band 3 in human erythrocytes: Novel mechanistic insights into drug structure, efficacy and toxicity.2016
- Author(s)
  Nakagawa M, Sugawara K, Goto T, Wakui H, Nunomura W.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 473 Issue: 4 Pages: 999-1004
- DOI
  10.1016/j.bbrc.2016.04.005
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09448, KAKENHI-PROJECT-15K09516
[Journal Article] Enzymatic and thermodynamic profiles of a heterotetramer lactate dehydrogenase isozyme in swine.2016
- Author(s)
  Goto, T., Sugawara, K., Nakamura, S., Kidokoro, S., Wakui, H., & Nunomura, W.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 474 Issue: 4 Pages: 860-867
- DOI
  10.1016/j.bbrc.2016.09.118
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09448, KAKENHI-PROJECT-15K09516
[Journal Article] Distribution of glomerular IgG subclass deposits in patients with membranous nephropathy and ant-U1 ribonucleoprotein antibody2012
- Author(s)
  Omokawa A, Komatsuda A, Nara M, Fujiwara T, Sato R, Togashi M, Okuyama S, Sawada K, Wakui H
- Journal Title
  
  Nephrol Dial Transplant
  
  Volume: 27 Pages: 1937-1941
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591017
[Journal Article] 多彩な腎疾患:臨床症例と動物モデルから学ぶ2011
- Author(s)
  涌井秀樹
- Journal Title
  
  秋田県医師会雑誌
  
  Volume: 61 Pages: 87-99
- NAID
  40018790372
- Data Source
  KAKENHI-PROJECT-21591017
[Journal Article] Progressive glomerulopathy with unusual deposits of striated structures : a new disease entity2010
- Author(s)
  Ohtani H, Wakui H, Komatsuda A, Goto H, Tada M, Ozawa M, Kobayashi R, Sawada K
- Journal Title
  
  Nephrol Dial Transplant
  
  Volume: 25 Pages: 2016-2019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591017
[Journal Article] GATA-3 is upregulated in peripheral blood mononuclear cells from patients with minimal change nephrotic syndrome2009
- Author(s)
  Komatsuda A, Wakui H, Iwamoto K, Togashi M, Masai R, Maki N, Sawada K
- Journal Title
  
  Clin Nephrol
  
  Volume: 71 Pages: 608-616
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591017
[Journal Article] Interaction of alpha-actinin-4 with class I PxxP motif-containing OK/SW-CL.16 protein2007
- Author(s)
  Togashi M, Okuyama S, Wakui H, Komatsuda A, Suzuki D, Toyoda M, SawadaK
- Journal Title
  
  Nephron Experimental Nephrology 107(2)
  
  Pages: 65-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590877
[Journal Article] 微小変化型ネフローゼ症候群2006
- Author(s)
  涌井秀樹
- Journal Title
  
  日本臨床増刊号分子腎臓病学 64巻増刊号2
  
  Pages: 408-412
- Data Source
  KAKENHI-PROJECT-18590877
[Journal Article] 微小変化型ネフローゼ症候群2006
- Author(s)
  涌井秀樹, 小松田敦
- Journal Title
  
  日本臨牀64(増刊2)巻
  
  Pages: 408-412
- Data Source
  KAKENHI-PROJECT-18590877
[Journal Article] 73-kDa molecular chaperone HSP73 is a direct target of antibiotic gentamicin.2004
- Author(s)
  Miyazaki T, Sagawa R, Honma T, Noguchi S, Harada T, Komatsuda A, Ohtani H, Wakui H, Sawada KI, Otaka M, Watanabe S, Jikei M, Ogawa N, Hamada F, Itoh H.
- Journal Title
  
  J Biol Chem 279(17)
  
  Pages: 17295-17300
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571011
[Journal Article] Interaction of the spectrin-like repeats of alpha-actinin-4 with humanin peptide2004
- Author(s)
  Kigawa A, Wakui H, Maki N, Okuyama S, Masai R, Ohtani H, Komatsuda A, Suzuki D, Toyoda M, Kobayashi R, Sawada K
- Journal Title
  
  Clin Exp Nephrol 8-4
  
  Pages: 331-338
- NAID
  10014091272
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571010
[Journal Article] Analysis of mutations in Alpha-actinin-4 and podocin genes of patients with chronic renal failure due to sporadic focal segmental glomerulosclerosis2003
- Author(s)
  Komatsuda A, Wakui H, Maki N., Kigawa A, Goto H, Ohtani H, Hamai K, Oyama Y, Hirokawa M, Sawada K, Imai H
- Journal Title
  
  Ren Fail 25-1
  
  Pages: 87-93
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571010
[Journal Article] Renal alpha-actinin-4 : Purification and puromycin aminonucleoside-binding property2003
- Author(s)
  Goto H, Wakui H, Komatsuda A, Ohtani H, Imai H, Sawada K, Kobayashi R
- Journal Title
  
  Nephron Exp Nephrol 93-1
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571010
[Journal Article] Mammalian HSP60 is quickly sorted into the mitochondria under conditions of dehydration.2002
- Author(s)
  Itoh H, Komatsuda A, Ohtani H, Wakui H, et al.
- Journal Title
  
  Eur J Biochem 269(23)
  
  Pages: 5931-5938
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571011
[Journal Article] Mammalian HSP60 is quickly sorted into the mitochondria under conditions of dehydration.2002
- Author(s)
  Itoh H, Komatsuda A, Ohtani H, Wakui H, Imai H, Sawada K, Otaka M, Ogura M, Suzuki A, Hamada F.
- Journal Title
  
  Eur J Biochem 269(23)
  
  Pages: 5931-5938
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571011
[Journal Article] GATA-3 is up-regulated in peripheral blood mononuclear cells from patients with minimal change nephrotic syndrome
- Author(s)
  Komatsuda A, Wakui H, Iwamoto K, Togashi M, Masai R, Maki N, Sawada K
- Journal Title
  
  Clinical Nephrology (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590877
[Presentation] 膜性腎症の糸球体蛋白質のプロテオーム解析2021
- Author(s)
  加賀一、小松田敦、涌井秀樹・
- Organizer
  第51回日本腎臓学会東部学術大会
- Data Source
  KAKENHI-PROJECT-19K08694
[Presentation] Characterization of Glomerular Proteins in Primary and Bucillamine-induced Membranous Nephropathy2021
- Author(s)
  加賀一、小松田敦、涌井秀樹、堂前直
- Organizer
  日本腎臓学会
- Data Source
  KAKENHI-PROJECT-19K08694
[Presentation] 抗リウマチ薬メトトレキサートとMIFサイトカインファミリータンパク質の相互作用解析2017
- Author(s)
  杉島小雪, 松村洋寿, 面川歩, 布村渉, 堂前直, 尾高雅文, 廣川誠, 涌井秀樹
- Organizer
  第11回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-15K09516
[Presentation] トトレキサート新規標的タンパク質マクロファージ遊走阻害因子の構造機能解析2017
- Author(s)
  松村洋寿, 杉島小雪, 面川歩, 布村渉, 堂前直, 尾高雅文, 廣川誠, 涌井秀樹
- Organizer
  第11回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-15K09516
[Presentation] リウマチ薬メトトレキサート新規標的タンパク質としてのマクロファージ遊走阻害因子の機能及び相互作用解析2017
- Author(s)
  杉島小雪, 松村洋寿, 面川歩, 尾高雅文, 廣川誠, 涌井秀樹
- Organizer
  第69回日本生物工学学会大会
- Data Source
  KAKENHI-PROJECT-15K09516
[Presentation] メトトレキサート新規標的タンパク質としてのマクロファージ遊走阻害因子の同定と構造機能解析2017
- Author(s)
  松村洋寿, 杉島小雪, 面川歩, 布村渉, 堂前直, 尾高雅文, 廣川誠, 涌井秀樹
- Organizer
  第44回生体分子科学討論会
- Data Source
  KAKENHI-PROJECT-15K09516
[Presentation] リウマチ薬メトトレキサート新規標的タンパク質としてのマクロファージ遊走阻害因子との相互作用解析2017
- Author(s)
  杉島小雪, 松村洋寿, 面川歩, 布村渉, 堂前直, 尾高雅文, 廣川誠, 涌井秀樹
- Organizer
  第44回生体分子科学討論会
- Data Source
  KAKENHI-PROJECT-15K09516
[Presentation] ヒドロキシクロロキンを用いた乳酸脱水素酵素の活性阻害による細胞増殖抑制2016
- Author(s)
  後藤樹史，菅原琴美，浅沼研，中川瑞希，小林五十鈴，鵜生川久美，山下順助，髙橋直人，澤田賢一，涌井秀樹，布村渉
- Organizer
  第68回日本細胞生物学会大会/日本ケミカルバイオロジー学会第11回年会/合同大会
- Place of Presentation
  京都テレサ（京都府京都市）
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-15K09516
[Presentation] Conserved and unique enzymatic and thermodynamic properties of lactate dehydrogenase in skeletal muscle of ectothermic, mesothermic and endothermic vertebrates2016
- Author(s)
  Goto T, Nakagawa M, Sugawara K, Takahashi T, Yonezawa M, Wakui H, Nunomura W
- Organizer
  The 22nd International Congress of Zoology
- Place of Presentation
  沖縄コンベンションセンター（沖縄県宜野湾市）
- Year and Date
  2016-11-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09516
[Presentation] Inhibition of heterotetramer lactate dehydrogenase isozyme blocked cell proliferation of K5622016
- Author(s)
  Goto T, Sugawara K, Asanuma K, Ubukawa K, Guo Y, Kobayashi I, Takahashi N, Wakui H, Nunomura W
- Organizer
  The 12th International Congress of Cell Biology
- Place of Presentation
  プラハ（チェコ共和国）
- Year and Date
  2016-06-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09516
[Presentation] Inhibition of lactate dehydrogenase isozymes blocked cell proliferation.2015
- Author(s)
  Goto T, Sugawara K, Nakagawa M, Kobayashi I, Ubukawa K, Asanuma K, Yamashita J, Sawada K, Wakui H, Nunomura W.
- Organizer
  American Society for Cell Biology 2015 Meeting
- Place of Presentation
  San Diego, USA
- Year and Date
  2015-12-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09516

1. KOMATSUDA Atsushi (70272044)

# of Collaborated Projects: 8 results

# of Collaborated Products: 15 results
2. ITOH Hideaki (80168369)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
3. 堂前直 (00321787)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. HATAKEYAMA Takashi (20422149)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KOBAYASHI Ryoji (00020917)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 大谷浩 (20333932)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 布村渉 (70256478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
8. ODAKA Masafumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
9. MSTSUMURA Hirotoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. OMOKAWA Ayumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results

WAKUI Hideki 涌井 秀樹

涌井 秀樹 ワクイ ヒデキ

Research Projects

Research Products

Co-Researchers

The study to identify novel pathogenesis and autoantigens in patients with membranous nephropathy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of novel proteins that bind to various immunosuppressive / immunomodulatory drugs and clinical implications in the immune systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular interaction that is important for the maintenance of glomerular filtration barrier and its significance in the signal transduction systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Signaling factors that interact with actinin-4, a component molecule of the glomerular filtration barrierPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Gene expression profiling of peripheral blood mononuclear cells from patients with minimal change nephrotic syndrome

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Interaction between glomerular filtration barrier component actinin-4 and nephrosis-inducing factorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of protective roles for renal injury by heat shock proteins treansfected with HSP genes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study on an immunosuppressant mizoribine-binding renal proteins (esp. molecular chaperones)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

腎の免疫抑制剤FK506結合蛋白質の精製とFK506腎毒性発現に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 分子腎臓病学、微小変化型ネフローゼ症候群2006

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Hydroxychloroquine binding to cytoplasmic domain of Band 3 in human erythrocytes: Novel mechanistic insights into drug structure, efficacy and toxicity.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enzymatic and thermodynamic profiles of a heterotetramer lactate dehydrogenase isozyme in swine.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Distribution of glomerular IgG subclass deposits in patients with membranous nephropathy and ant-U1 ribonucleoprotein antibody2012

Author(s)

Journal Title

Data Source

[Journal Article] 多彩な腎疾患:臨床症例と動物モデルから学ぶ2011

Author(s)

WAKUI Hideki 涌井秀樹

涌井秀樹ワクイヒデキ