WADA HISASHI 和田尚

… Alternative Names

Wada Hisashi 和田尚

和田尚ワダヒサシ

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Researcher Number	70243459
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 特任教授(常勤)
Affiliation (based on the past Project Information) *help	2022 – 2024: 大阪大学, 大学院医学系研究科, 特任教授(常勤) 2019 – 2021: 大阪大学, 医学系研究科, 特任教授(常勤) 1993: 岡山大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / General surgery Except Principal Investigator Basic Section 56030:Urology-related / Basic Section 55020:Digestive surgery-related / Basic Section 50010:Tumor biology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator 骨髄由来抑制細胞 / 免疫チェックポイント / T細胞疲弊 / 腫瘍浸潤T細胞 / ImmunoScore / ImmunoGram / TAM / Treg / MDSC / 効果T細胞 … More / 制御性T細胞 / 免疫抑制因子 / 腫瘍組織浸潤効果T細胞 / 腫瘍内浸潤免疫担当細胞 / 免疫チェックポイント阻害剤 / RNAシークエンス / 多重蛍光免疫組織化学染色 / フローサイトメトリー / 腫瘍内浸潤免疫細胞 / 癌 / がん / トランスジェニックマウス / 抗TCRVbeta抗体 / キラーT前駆細胞 / 寛容 / 皮膚移植 / T細胞 / 免疫 … More Except Principal Investigator 制御性T細胞 / 尿路上皮癌 / CCR8 / 免疫チェックポイント分子 / T細胞疲弊化 / 胃癌 / Precursor T細胞 / リンパ節 / 抗PD1抗体 / CCL1 / 腫瘍免疫環境 / ISH法 / CCR8発現細胞 / CCL1発現細胞 / 血液 / 細菌叢 / Ｄアミノ酸 / CD31 / 血管新生 / 腎細胞癌 / エクソソーム / Cutibacterium acnes / 細胞外小胞 / Firmicutes / 癌免疫療法 / 細菌関連代謝物 / 血液内細菌叢 / 腫瘍浸潤リンパ球 / 腫瘍免疫 / 食道癌 / ノックアウトマウス / シングルセルシークエンス / 膀胱癌 Less

CCL1-CCR8経路を介した腫瘍内Treg制御による治療法の探索
- Principal Investigator
  
  中井慈人
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Osaka University
ニボルマブ結合T細胞検出法を用いた免疫チェックポイント阻害薬の治療効果機序の解明
- Principal Investigator
  
  西塔拓郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka University
Impact of tumor-associated B cells in esophageal cancer
- Principal Investigator
  
  林芳矩
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Osaka University
Elucidation of the cancer local immune status constructed by the systemic circulating microbiome and bacterial-related metabolism in urogenital cancer
- Principal Investigator
  
  河嶋厚成
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Osaka University
Development of cancer immunotherapy for urothelial carcinoma targeting tissue infiltrating regulatory T cells
- Principal Investigator
  
  KAWASHIMA ATSUNARI
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Osaka University
Attempt of segmentation of positive / negative factor and absolute evaluation of intra-tumor immunityPrincipal Investigator
- Principal Investigator
  
  Wada Hisashi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka University
宿主T細胞数制御による免疫寛容の誘導Principal Investigator
- Principal Investigator
  
  和田尚
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General surgery
- Research Institution
  Okayama University

All 2023 2022 2021 2020 2019

All Journal Article Presentation Patent

[Journal Article] Integrated analysis of phase 1a and 1b randomized controlled trials; Treg-targeted cancer immunotherapy with the humanized anti-CCR4 antibody, KW-0761, for advanced solid tumors2023
- Author(s)
  Fujikawa Kaoru、Saito Takuro、Kurose Koji、Kojima Takashi、Funakoshi Takeru、Sato Eiichi、Kakimi Kazuhiro、Iida Shinsuke、Doki Yuichiro、Oka Mikio、Ueda Ryuzo、Wada Hisashi
- Journal Title
  
  PLOS ONE
  
  Volume: 18 Issue: 9 Pages: 0291772-0291772
- DOI
  10.1371/journal.pone.0291772
- Data Source
  KAKENHI-PROJECT-23K08194
[Journal Article] C-reactive protein kinetics as a predictive marker for long-term outcome of immune checkpoint inhibitors in oesophagogastric cancer2023
- Author(s)
  Nose Yohei、Saito Takuro、Kurokawa Yukinori、Takahashi Tsuyoshi、Yamamoto Kazuyoshi、Momose Kota、Yamashita Kotaro、Tanaka Koji、Makino Tomoki、Eguchi Hidetoshi、Doki Yuichiro、Wada Hisashi
- Journal Title
  
  BJC Reports
  
  Volume: 1 Issue: 1 Pages: 7-7
- DOI
  10.1038/s44276-023-00005-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K08194
[Journal Article] Bacteria-derived DNA in serum extracellular vesicles are biomarkers for renal cell carcinoma2023
- Author(s)
  Uemura Toshihiro、Kawashima Atsunari、Jingushi Kentaro、Motooka Daisuke、Saito Takuro、Nesrine Sassi、Oka Toshiki、Okuda Yohei、Yamamoto Akinaru、Yamamichi Gaku、Tomiyama Eisuke、Ishizuya Yu、Yamamoto Yoshiyuki、Kato Taigo、Hatano Koji、Tsujikawa Kazutake、Wada Hisashi、Nonomura Norio
- Journal Title
  
  Heliyon
  
  Volume: 9 Issue: 9 Pages: e19800-e19800
- DOI
  10.1016/j.heliyon.2023.e19800
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09469, KAKENHI-PROJECT-23K24472
[Journal Article] Density and maturity of peritumoral tertiary lymphoid structures in oesophageal squamous cell carcinoma predicts patient survival and response to immune checkpoint inhibitors.2023
- Author(s)
  Hayashi Y, Makino T, Sato E, Ohshima K, Nogi Y, Kanemura T, Honma K, Yamashita K, Saito T, Tanaka K, Yamamoto K, Takahashi T, Kurokawa Y, Miyata H, Nakajima K, Wada H, Morii E, Eguchi H, Doki Y.
- Journal Title
  
  Br J Cancer.
  
  Volume: - Issue: 12 Pages: 2175-2185
- DOI
  10.1038/s41416-023-02235-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08776, KAKENHI-PROJECT-22K07278, KAKENHI-PROJECT-23K08194
[Journal Article] Tumor endothelial cell-induced CD8 + T-cell exhaustion via GPNMB in hepatocellular carcinoma2022
- Author(s)
  Sakano Yoshihiro、Noda Takehiro、Kobayashi Shogo、Sasaki Kazuki、Iwagami Yoshifumi、Yamada Daisaku、Tomimaru Yoshito、Akita Hirofumi、Gotoh Kunihito、Takahashi Hidenori、Asaoka Tadafumi、Tanemura Masahiro、Wada Hisashi、Doki Yuichiro、Eguchi Hidetoshi
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 5 Pages: 1625-1638
- DOI
  10.1111/cas.15331
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09146, KAKENHI-PROJECT-19H03729, KAKENHI-PROJECT-22K08799, KAKENHI-PROJECT-22K08870
[Journal Article] The impact of CCR8+ regulatory T cells on cytotoxic T cell function in human lung cancer2022
- Author(s)
  Miya Haruna, Azumi Ueyama, Yoko Yamamoto, Michinari Hirata, Kumiko Goto, Hiroshi Yoshida, Naoko Higuchi, Tetsuya Yoshida, Yujiro Kidani, Yamami Nakamura, Morio Nagira, Atsunari Kawashima, Kota Iwahori, Yasushi Shintani, Naganari Ohkura and Hisashi Wada
- Journal Title
  
  Sci Rep.
  
  Volume: 12 Issue: 1 Pages: 1-12
- DOI
  10.1038/s41598-022-09458-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03729
[Journal Article] Tumor-infiltrating ICOS+ Effector Regulatory T-Cells in Oral Squamous Cell Carcinoma as a Promising Biomarker for Prognosis and ‘Hot’ Tumor2022
- Author(s)
  HITOMI KAJIKAWA, MICHINARI HIRATA, MIYA HARUNA, AZUMI UEYAMA, KATSUTOSHI HIROSE, ATSUNARI KAWASHIMA, KOTA IWAHORI, KAZUHIDE MATSUNAGA, SATORU TOYOSAWA, NARIKAZU UZAWA and HISASHI WADA
- Journal Title
  
  Anticancer Research
  
  Volume: 42 Issue: 5 Pages: 2383-2393
- DOI
  10.21873/anticanres.15717
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03729
[Journal Article] Phase Ib study on the humanized anti-CCR4 antibody, KW-0761, in advanced solid tumors2021
- Author(s)
  Saito T, Kurose K, Kojima T, Funakoshi T, Sato E, Nishikawa H, Nakajima J, Seto Y, Kakimi K, Iida S, Doka Y, Oka M, Ueda R, Wada H.
- Journal Title
  
  Nagoya Journal of Medical Science
  
  Volume: 83 Issue: 4 Pages: 827-840
- DOI
  10.18999/nagjms.83.4.827
- NAID
  120007174347
- ISSN
  0027-7622
- URL
  https://nagoya.repo.nii.ac.jp/records/2001663
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03729
[Journal Article] Two distinct phenotypes of immunologically hot gastric cancer subtypes.2021
- Author(s)
  Saito N, Kobayashi Y, Nagaoka K, Kushihara Y, Sato Y, Wada I, Kakimi K, Seto Y.
- Journal Title
  
  Biochem Biophys Rep.
  
  Volume: 28 Pages: 1-6
- DOI
  10.1016/j.bbrep.2021.101167
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03729
[Journal Article] The impact of ICOS+ regulatory T cells and Helicobacter pylori infection on the prognosis of patients with gastric and colorectal cancer: potential prognostic benefit of pre-operative eradication therapy2021
- Author(s)
  Urakawa Shinya、Yamasaki Makoto、Makino Tomoki、Kurokawa Yukinori、Yamamoto Kei、Goto Kumiko、Haruna Miya、Hirata Michinari、Morimoto-Okazawa Akiko、Kawashima Atsunari、Iwahori Kota、Mizushima Tsunekazu、Sato Eiichi、Mori Masaki、Doki Yuichiro、Wada Hisashi
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: 70 Issue: 2 Pages: 443-452
- DOI
  10.1007/s00262-020-02696-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03729
[Journal Article] 多重蛍光免疫染色法を用いた食道がん化学療法の効果予測2021
- Author(s)
  山本慧、和田尚
- Journal Title
  
  癌と化学療法
  
  Volume: 48 Pages: 336-340
- Data Source
  KAKENHI-PROJECT-19H03729
[Journal Article] Depletion of central memory CD8+ T cells might impede the antitumor therapeutic effect of Mogamulizumab2021
- Author(s)
  Maeda Yuka、Wada Hisashi、Sugiyama Daisuke、Saito Takuro、Irie Takuma、Itahashi Kota、Minoura Kodai、Suzuki Susumu、Kojima Takashi、Kakimi Kazuhiro、Nakajima Jun、Funakoshi Takeru、Iida Shinsuke、Oka Mikio、Shimamura Teppei、Doi Toshihiko、Doki Yuichiro、Nakayama Eiichi、Ueda Ryuzo、Nishikawa Hiroyoshi
- Journal Title
  
  Nature Communications
  
  Volume: 12(1) Issue: 1 Pages: 7280-7280
- DOI
  10.1038/s41467-021-27574-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H04841, KAKENHI-PROJECT-17H06162, KAKENHI-PROJECT-19H03729, KAKENHI-PROJECT-20H04281, KAKENHI-PROJECT-21K07112, KAKENHI-PROJECT-20K21832
[Journal Article] Endogenous CXCL9 affects prognosis by regulating tumor-infiltrating NK cells in intrahepatic cholangiocarcinoma2020
- Author(s)
  Fukuda Y, Asaoka T, Eguchi H, Yokota Y, Kubo M1, Kinoshita M, Urakawa S, Iwagami Y, Tomimaru Y, Akita H, Noda T, Gotoh K, Kobayashi S, Hirata M, Wada H, Mori M, Doki Y.
- Journal Title
  
  Cancer Sci.
  
  Volume: 111 Issue: 2 Pages: 323-333
- DOI
  10.1111/cas.14267
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03729, KAKENHI-PROJECT-17K10696
[Journal Article] Immunotherapeutic potential of CD4 and CD8 single-positive T cells in thymic epithelial tumors2020
- Author(s)
  Yoko Yamamoto, Kota Iwahori, Soichiro Funaki, Mitsunobu Matsumoto, Michinari Hirata, Tetsuya Yoshida, Ryu Kanzaki, Takashi Kanou, Naoko Ose, Masato Minami, Eiichi Sato, Atsushi Kumanogoh, Yasushi Shintani, Meinoshin Okumura, Hisashi Wada
- Journal Title
  
  Sci Rep
  
  Volume: 10 Issue: 1 Pages: 4064-4064
- DOI
  10.1038/s41598-020-61053-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03729, KAKENHI-PROJECT-18K16419, KAKENHI-PROJECT-18K08143
[Journal Article] Tumour Grade Significantly Correlates With Total Dysfunction of Tumour Tissue-Infiltrating Lymphocytes in Renal Cell Carcinoma2020
- Author(s)
  Kawashima A, Kanazawa T, Kidani Y, Yoshida T, Hirata M, Nishida K, Nojima S, Yamamoto Y, Kato T, Hatano K, Ujike T, Nagahara A, Fujita K, Morimoto-Okazawa A, Iwahori K, Uemura M, Imamura R, Ohkura N, Morii E, Sakaguchi S, Wada H, Nonomura N.
- Journal Title
  
  Sci Rep .
  
  Volume: 10 Issue: 1 Pages: 6220-6220
- DOI
  10.1038/s41598-020-63060-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03452, KAKENHI-PROJECT-17K19555, KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-19H03729, KAKENHI-PROJECT-19K16557
[Journal Article] Docetaxel Upregulates HMGB1 Levels in Non-small Cell Lung Cancer2020
- Author(s)
  Haruna Miya、Hirata Michinari、Iwahori Kota、Kanazawa Takayuki、Yamamoto Yoko、Goto Kumiko、Kawashima Atsunari、Morimoto-Okazawa Akiko、Funaki Soichiro、Shintani Yasushi、Kumanogoh Atsushi、Wada Hisashi
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 43 Issue: 3 Pages: 399-403
- DOI
  10.1248/bpb.b19-00702
- NAID
  130007804428
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2020-03-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03729
[Journal Article] Tumor‐infiltrating M2 macrophage in pretreatment biopsy sample predicts response to chemotherapy and survival in esophageal cancer2020
- Author(s)
  Yamamoto Kei、Makino Tomoki、Sato Eiichi、Noma Toshiki、Urakawa Shinya、Takeoka Tomohira、Yamashita Kotaro、Saito Takuro、Tanaka Koji、Takahashi Tsuyoshi、Kurokawa Yukinori、Yamasaki Makoto、Nakajima Kiyokazu、Mori Masaki、Doki Yuichiro、Wada Hisashi
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 4 Pages: 1103-1112
- DOI
  10.1111/cas.14328
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03729
[Journal Article] Integrative immunogenomic analysis of gastric cancer dictates novel immunological classification and the functional status of tumor‐infiltrating cells2020
- Author(s)
  Sato Y、Wada I、Odaira K、Hosoi A、Kobayashi Y、Nagaoka K、Karasaki T、Matsushita H、Yagi K、Yamashita H、Fujita M、Watanabe S、Kamatani T、Miya F、Mineno J、Nakagawa H、Tsunoda T、Takahashi S、Seto Y、Kakimi K
- Journal Title
  
  Clinical & Translational Immunology
  
  Volume: 9 Issue: 10 Pages: 9-9
- DOI
  10.1002/cti2.1194
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K18080, KAKENHI-PROJECT-19H03528, KAKENHI-PROJECT-19H03729, KAKENHI-PROJECT-20K09637
[Journal Article] Heterogeneity of Treg/Th17 According to Cancer Progression and Modification in Biliary Tract Cancers via Self-Producing Cytokines.2020
- Author(s)
  Kinoshita M, Kobayashi S, Gotoh K, Kubo M, Hayashi K, Iwagami Y, Yamada D, Akita H, Noda T, Asaoka T, Takeda Y, Tanemura M, Eguchi H, Urakawa S, Goto K, Maekawa K, Wada H, Mori M, Doki Y.
- Journal Title
  
  Dig Dis Sci.
  
  Volume: 65 Issue: 10 Pages: 2937-2948
- DOI
  10.1007/s10620-019-06011-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09120, KAKENHI-PROJECT-19H03729, KAKENHI-PROJECT-18K08703
[Journal Article] Clinical importance of the expression of CD4+CD8+ T cells in Renal Cell Carcinoma.2020
- Author(s)
  Nishida K, Kawashima A, Kanazawa T, Kidani Y, Yoshida T, Hirata M, Yamamoto K, Yamamoto Y, Sawada M, Kato R, Kato T, Hatano K, Ujike T, Fujita K, Uemura M, Morimoto-Okazawa A, Iwahori K, Yamasaki M, Ohkura N, Sakaguchi S, Nonomura N, Doki Y, Wada H.
- Journal Title
  
  Int Immunol
  
  Volume: Jan24 Issue: 5 Pages: 347-357
- DOI
  10.1093/intimm/dxaa004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03729, KAKENHI-PROJECT-16H06295
[Journal Article] PD-1+ Tim3+ tumor-infiltrating CD8 T cells sustain the potential for IFN-γ production, but lose cytotoxic activity in ovarian cancer2020
- Author(s)
  Sawada Masaaki、Goto Kumiko、Morimoto-Okazawa Akiko、Haruna Miya、Yamamoto Kei、Yamamoto Yoko、Nakagawa Satoshi、Hiramatsu Kosuke、Matsuzaki Shinya、Kobayashi Eiji、Kawashima Atsunari、Hirata Michinari、Iwahori Kota、Kimura Toshihiro、Ueda Yutaka、Kimura Tadashi、Wada Hisashi
- Journal Title
  
  International Immunology
  
  Volume: 32 Issue: 6 Pages: 397-405
- DOI
  10.1093/intimm/dxaa010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03729
[Journal Article] Peri-operative monocyte count is a marker of poor prognosis in gastric cancer: increased monocytes are a characteristic of myeloid-derived suppressor cells.2019
- Author(s)
  Shinya Urakawa, Makoto Yamasaki, Kumiko Goto, Miya Haruna, Michinari Hirata, Akiko Morimoto-Okazawa, Atsunari Kawashima, Kota Iwahori, Tomoki Makino, Yukinori Kurokawa, Tomomi Yamada, Masaki Mori, Yuichiro Doki, Hisashi Wada.
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: 68 Issue: 8 Pages: 1341-1350
- DOI
  10.1007/s00262-019-02366-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03729
[Journal Article] Peripheral T cell cytotoxicity predicts T cell function in the tumor microenvironment2019
- Author(s)
  Iwahori Kota、Shintani Yasushi、Funaki Soichiro、Yamamoto Yoko、Matsumoto Mitsunobu、Yoshida Tetsuya、Morimoto-Okazawa Akiko、Kawashima Atsunari、Sato Eiichi、Gottschalk Stephen、Okumura Meinoshin、Kumanogoh Atsushi、Wada Hisashi
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 2636-2636
- DOI
  10.1038/s41598-019-39345-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08143, KAKENHI-PROJECT-19H03729, KAKENHI-PROJECT-19H03745
[Journal Article] Phenotypic Analysis of Tumor Tissue?Infiltrating Lymphocytes in Tumor Microenvironment of Bladder Cancer and Upper Urinary Tract Carcinoma2019
- Author(s)
  Kawashima Atsunari、Kanazawa Takayuki、Jingushi Kentaro、Kato Taigo、Ujike Takeshi、Nagahara Akira、Fujita Kazutoshi、Morimoto-Okazawa Akiko、Iwahori Kota、Uemura Motohide、Imamura Ryoichi、Wada Hisashi、Nonomura Norio
- Journal Title
  
  Clinical Genitourinary Cancer
  
  Volume: 17 Issue: 2 Pages: 114-124
- DOI
  10.1016/j.clgc.2018.11.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16790, KAKENHI-PROJECT-19H03729
[Patent] CCR8を抗原として認識するキメラ抗原受容体2022
- Inventor(s)
  大倉永也、坂口志文、和田尚
- Industrial Property Rights Holder
  大倉永也、坂口志文、和田尚
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-19H03729
[Patent] 癌治療用医薬組成物2019
- Inventor(s)
  大倉永也、坂口志文、田中淳、和田尚、河嶋厚成、野々村祝夫
- Industrial Property Rights Holder
  大倉永也、坂口志文、田中淳、和田尚、河嶋厚成、野々村祝夫
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Acquisition Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-19H03729
[Patent] 新規抗CCR8抗体2019
- Inventor(s)
  大倉永也、田中淳、坂口志文、和田尚、河嶋厚成
- Industrial Property Rights Holder
  大倉永也、田中淳、坂口志文、和田尚、河嶋厚成
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Acquisition Date
  2021
- Data Source
  KAKENHI-PROJECT-19H03729
[Presentation] The impact of CCR8+ regulatory T cells on cytotoxic T cell function in human lung cancer2022
- Author(s)
  Miya Haruna, Azumi Ueyama, Yoko Yamamoto, Michinari Hirata, Kumiko Goto, Hiroshi Yoshida, Naoko Higuchi, Tetsuya Yoshida, Yujiro Kidani, Yamami Nakamura, Morio Nagira, Atsunari Kawashima, Kota Iwahori, Yasushi Shintani, Naganari Ohkura and Hisashi Wada
- Organizer
  JSMO2022
- Data Source
  KAKENHI-PROJECT-19H03729
[Presentation] The potential prognostic benefit of pre-operative eradication therapy to Helicobacter pylori infection on gastric cancer2021
- Author(s)
  Takuro Saito, Shinya Urakawa, Hisashi Wada, Kotaro Yamashita, Koji Tanaka, Kazuyoshi Yamamoto, Tomoki Makino, Tsuyoshi Takahashi, Yukinori Kurokawa
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03729
[Presentation] 胃癌患者におけるニボルマブ治療の血中治療効果予測マーカーの同定2021
- Author(s)
  野瀬陽平、西塔拓郎、和田尚、黒川幸典、高橋剛、山本和義、牧野知紀、山﨑誠、江口英利、土岐祐一郎
- Organizer
  第76回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-19H03729
[Presentation] Examination of the effect of tumor endothelial cells on the immune microenvironment in hepatocellular carcinoma2021
- Author(s)
  Yoshihiro Sakano, Takehiro Noda, Shogo Kobayashi, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Yoshito Tomimaru, Hidenori Takahashi, Hisashi Wada, Yuichiro Doki, Hidetoshi Eguchi
- Organizer
  第59回癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03729
[Presentation] 肝細胞癌において腫瘍血管内皮細胞は腫瘍浸潤Tリンパ球の疲弊化を促進する2021
- Author(s)
  阪野佳弘、野田剛広、小林省吾、佐々木一樹、岩上佳史、山田大作、富丸慶人、秋田裕史、後藤邦仁、高橋秀典、和田尚、土岐祐一郎、江口英利
- Organizer
  第41回日本分子腫瘍マーカー研究会
- Data Source
  KAKENHI-PROJECT-19H03729

1. 西塔拓郎 (20646468)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
2. KAWASHIMA ATSUNARI (50746568)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. 野々村祝夫 (30263263)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. 牧野知紀 (80528620)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
5. 佐藤永一 (60408101)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. 垣見和宏 (80273358)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 岩堀幸太 (80566448)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
8. 森本晶子 (60601193)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. 林芳矩 (20882236)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 木村友則 (00631300)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 元岡大祐 (10636830)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 神宮司健太郎 (80707571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 中井慈人 (40912027)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 黒川幸典 (10470197)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. 森井英一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 野田剛広

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 植村俊彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 佐藤靖祥

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 種村匡弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 江口英利

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 土岐祐一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 島村徹平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

WADA HISASHI 和田 尚

Wada Hisashi 和田 尚

和田 尚 ワダ ヒサシ

Research Projects

Research Products

Co-Researchers

CCL1-CCR8経路を介した腫瘍内Treg制御による治療法の探索

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ニボルマブ結合T細胞検出法を用いた免疫チェックポイント阻害薬の治療効果機序の解明

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Impact of tumor-associated B cells in esophageal cancer

Principal Investigator

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Elucidation of the cancer local immune status constructed by the systemic circulating microbiome and bacterial-related metabolism in urogenital cancer

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Development of cancer immunotherapy for urothelial carcinoma targeting tissue infiltrating regulatory T cells

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Attempt of segmentation of positive / negative factor and absolute evaluation of intra-tumor immunityPrincipal Investigator

Principal Investigator

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宿主T細胞数制御による免疫寛容の誘導Principal Investigator

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[Journal Article] Integrated analysis of phase 1a and 1b randomized controlled trials; Treg-targeted cancer immunotherapy with the humanized anti-CCR4 antibody, KW-0761, for advanced solid tumors2023

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[Journal Article] C-reactive protein kinetics as a predictive marker for long-term outcome of immune checkpoint inhibitors in oesophagogastric cancer2023

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[Journal Article] Bacteria-derived DNA in serum extracellular vesicles are biomarkers for renal cell carcinoma2023

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[Journal Article] Density and maturity of peritumoral tertiary lymphoid structures in oesophageal squamous cell carcinoma predicts patient survival and response to immune checkpoint inhibitors.2023

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[Journal Article] Tumor endothelial cell-induced CD8 + T-cell exhaustion via GPNMB in hepatocellular carcinoma2022

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[Journal Article] The impact of CCR8+ regulatory T cells on cytotoxic T cell function in human lung cancer2022

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[Journal Article] Tumor-infiltrating ICOS+ Effector Regulatory T-Cells in Oral Squamous Cell Carcinoma as a Promising Biomarker for Prognosis and ‘Hot’ Tumor2022

Author(s)

WADA HISASHI 和田尚

Wada Hisashi 和田尚

和田尚ワダヒサシ