KUSAKA Hirofumi 日下博文

… Alternative Names

日下博文クサカヒロフミ

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Researcher Number	70250066
External Links
Affiliation (based on the past Project Information) *help	2006 – 2010: 関西医科大学, 医学部, 教授 2000 – 2004: 関西医科大学, 医学部, 教授 1993: 財団法人田附興風会, 医学研究所・第4部, 所員
Review Section/Research Field	Principal Investigator Neurology / Neurology Except Principal Investigator Neurology / Neurology
Keywords	Principal Investigator immunohistochemistry / frontotemporal dementia / ALS / Golgi apparatus / basophilic inclusion / motor neuron disease / 封入体単離 / cystatin C / 免疫組織学 / 前頭側頭型痴呆 … More / 筋萎縮性側索硬化症 / ゴルジ器官 / 好塩基性封入体 / 運動ニューロン病 / 核細胞質間輸送 / 封入体筋炎 / ミオパチー / 病理学 / 脳神経疾患 … More Except Principal Investigator ALS / importin / transgenic mouse / SOD1 / iNOS / edaravone / IBM-BMT / nucleocytoplasmic transport / GRP78 / ER stress / MAP kinase / MAP kinase phosphatase / ERK / amyotrophic lateral sclerosis / knockout mouse / DNA double-strand breaks / Pathology / Myopathy / Neurology / DNA二本鎖切断 / ミオパチー / 病理学 / 脳神経疾患 / karyopherin / JNK pathway / β-catenin / SREBP-2 / phosphorylation / MAP kinase Kinase / inclusion body myositis / nuclear transport / リン酸化 / MAP kinase kinase / MAPキナーゼ / 封入体筋炎 / transgeneic mouse / transgenic nouse / Parkinson / nitric oxide synthese / superoxide dismutase / 交配実験 Less

Dynamic O-GlcNAc modification in inclusion body myositisPrincipal Investigator
- Principal Investigator
  
  KUSAKA Hirofumi, NAKANO Satoshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kansai Medical University
DNA double-strand breaks in inclusion body myositis
- Principal Investigator
  
  NAKANO Satoshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kansai Medical University
NOS-JNK-Cdk5 linkage in neurodegeneration of amyotrophic lateral sclerosis.
- Principal Investigator
  
  ITO Hidefumi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kansai Medical University
Analysis of MAP kinase cascades in inclusion body myositis
- Principal Investigator
  
  NAKANO Satoshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kansai Medical University
Relationship between motor neuron disease with basophilic inclusions and frontotemporal dementiaPrincipal Investigator
- Principal Investigator
  
  KUSAKA Hirofumi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kansai Medical University
Contribution of iNOS for neurodegeneration in ALS and Parkinson's disease
- Principal Investigator
  
  ITO Hidefumi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kansai Medical University
神経変性疾患の中枢神経組織における細胞骨格蛋白と神経伝達物質の免疫組織化学的検討
- Principal Investigator
  
  松本禎之
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Neurology
- Research Institution
  Tazuke Kofukai Medical Research Institute

All 2011 2010 2009 2008 2005 2004 2003 Other

All Journal Article Presentation Book

[Book] わかりやすい内科学(第3版)(井村裕夫編)(全身性疾患に伴う神経疾患)2008
- Author(s)
  日下博文
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-20591012
[Journal Article] Myonuclear breakdown in sporadic inclusion body myositis is accompanied by DNA double strand breaks.2011
- Author(s)
  Nishii M, Nakano S, Nakamura S, Wate R, Shinde A, Kaneko S, Kusaka H
- Journal Title
  
  Neuromuscul Disord. 21
  
  Pages: 345-52
- Data Source
  KAKENHI-PROJECT-20591012
[Journal Article] Smad ubiquitination regulatory factor-2 in progressive supranuclear palsy.2011
- Author(s)
  Nakamura M, Ito H, Nakamura Y, Wate R, Kaneko S, Nakano S, Matsumoto S, Kusaka H
- Journal Title
  
  Neuropathol Appl Neurobiol. 37
  
  Pages: 307-14
- Data Source
  KAKENHI-PROJECT-20591012
[Journal Article] Nuclear contour irregularity and abnormal transporter protein distribution in anterior horn cells in amyotrophic lateral sclerosis.2009
- Author(s)
  Kinoshita Y, Ito H, Hirano A, Fujita K, Wate R, Nakamura M, Kaneko S, Nakano S, Kusaka H
- Journal Title
  
  J Neuropathol Exp Neurol. 68
  
  Pages: 1184-92
- Data Source
  KAKENHI-PROJECT-20591012
[Journal Article] Intra-bone marrow-bone marrow transplantation slows disease progression and prolongs survival in G93A mutant SOD1 transgenic mice, an animal model mouse for amyotrophic lateral sclerosis.2009
- Author(s)
  Ohnishi S, Ito H, Suzuki Y, Adachi Y, Wate R, Zhang J, Nakano S, Kusaka H, Ikehara S
- Journal Title
  
  Brain Res. 1296
  
  Pages: 216-24
- Data Source
  KAKENHI-PROJECT-20591012
[Journal Article] The first Japanese patient with variant Creutzfeldt-Jakob disease (vCJD).2009
- Author(s)
  Shinde A, Kunieda T, Kinoshita Y, Wate R, Nakano S, Ito H, Yamada M, Kitamoto T, Nakamura Y, Matsumoto S, Kusaka H
- Journal Title
  
  Neuropathology. 29
  
  Pages: 713-9
- NAID
  10028192866
- Data Source
  KAKENHI-PROJECT-20591012
[Journal Article] Expression of caveolar components in primary desminopathy.2008
- Author(s)
  Shinde A, Nakano S, Sugawara M, Toyoshima I, Ito H, Tanaka K, Kusaka H
- Journal Title
  
  Neuromuscul Disord. 18
  
  Pages: 215-9
- Data Source
  KAKENHI-PROJECT-20591012
[Journal Article] Histone H1 is released from myonuclei and present in rimmed vacuoles with DNA in inclusion body myositis.2008
- Author(s)
  Nakano S, Shinde A, Fujita K, Ito H, Kusaka H
- Journal Title
  
  Neuromuscul Disord. 18
  
  Pages: 27-33
- Data Source
  KAKENHI-PROJECT-20591012
[Journal Article] Phosphorylated Smad2/3 immunoreactivity in sporadic and familial amyotrophic lateral sclerosis and its mouse model.2008
- Author(s)
  Nakamura M, Ito H, Wate R, Nakano S, Hirano A, Kusaka H
- Journal Title
  
  Acta Neuropathol. 115
  
  Pages: 327-34
- Data Source
  KAKENHI-PROJECT-20591012
[Journal Article] Immunohistochemical identification of messenger RNA-related proteins in basophilic inclusions of adult-onset atypical motor neuron disease.2008
- Author(s)
  Fujita K, Ito H, Nakano S, Kinoshita Y, Wate R, Kusaka H
- Journal Title
  
  Acta Neuropathol. 116
  
  Pages: 439-45
- Data Source
  KAKENHI-PROJECT-20591012
[Journal Article] In situ identification of hepatitis C virus RNA in muscle.2005
- Author(s)
  Ito H, Ito H, Nagano M, Nakano S, Shigeyoshi Y, Kusaka H
- Journal Title
  
  Neurology 64
  
  Pages: 1073-1075
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590917
[Journal Article] Messenger RNA degradation may be inhibited in sporadic inclusion body myositis.2005
- Author(s)
  Nakano S, Shinde A, Ito H, Ito H, Kusaka H
- Journal Title
  
  Neurology 65
  
  Pages: 420-425
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590917
[Journal Article] Radio-sensitivity of the cells from amyotrophic lateral sclerosis model mice transfected with human mutant SOD1.2005
- Author(s)
  Wate R, Takahashi S, Ito H, Kusaka H, Kubota Y, Suetomi K, Sato H, Okayasu R
- Journal Title
  
  J Radiat Res 46
  
  Pages: 67-73
- NAID
  110004041097
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590917
[Journal Article] Expression of an endoplasmic reticulum-resident chaperone, glucose-regulated stress protein 78, in the spinal cord of a mouse model of amyotrophic lateral sclerosis.2005
- Author(s)
  Wate R, Ito H, Zhang JH, Ohnishi S, Nakano S, Kusaka H
- Journal Title
  
  Acta Neuropathol 110
  
  Pages: 557-562
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590917
[Journal Article] Nucleolar characteristics of reducing bodies in reducing body myopathy.2004
- Author(s)
  Shinde A, Nakano S, Kusaka H, Nakaya Y, Sawada H, Kohara N, Shibasaki H
- Journal Title
  
  Acta Neuropathol 107
  
  Pages: 265-271
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590917
[Journal Article] MAP kinase phosphatase-1 is induced in abnormal fibers in inclusion body myositis.2003
- Author(s)
  Nakano S, Shinde A, Ito H, Ito H, Kusaka H
- Journal Title
  
  Neurology 61
  
  Pages: 322-326
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590917
[Journal Article] Localization of O-GlcNAc-modified proteins in neuromuscular diseases.
- Author(s)
  Nakamura S, Nakano S, Nishii M, Kaneko S, Kusaka H
- Journal Title
  
  Medical Molecular Morphology (in press)
- NAID
  10030832120
- Data Source
  KAKENHI-PROJECT-20591012
[Presentation] 封入体筋炎組織の空胞における核膜とライソゾーム成分の比較2010
- Author(s)
  中村聖香,中野智,日下博文,他
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京,東京国際フォーラム
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-20591012
[Presentation] 筋疾患筋組織におけるO-GlcNAC修飾蛋白の分布2009
- Author(s)
  中村聖香,中野智,日下博文,他
- Organizer
  第50回日本神経学会総会
- Place of Presentation
  仙台,仙台国際センター
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-20591012
[Presentation] 筋炎におけるDNA二本鎖切断修復酵素の検討2008
- Author(s)
  西井誠,中野智,日下博文,他
- Organizer
  第49回日本神経学会総会
- Place of Presentation
  横浜,パシフィコ横浜
- Year and Date
  2008-05-15
- Data Source
  KAKENHI-PROJECT-20591012

1. ITO Hidefumi (20250061)

# of Collaborated Projects: 7 results

# of Collaborated Products: 13 results
2. NAKANO Satoshi (30333206)

# of Collaborated Projects: 4 results

# of Collaborated Products: 18 results
3. ITO Seiji (80201325)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
4. NISHIZAWA Mikio (40192687)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. SHINDE Akiyo (10368235)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
6. 松本禎之 (80250075)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 今井輝国

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KUSAKA Hirofumi 日下 博文

日下 博文 クサカ ヒロフミ

Research Projects

Research Products

Co-Researchers

Dynamic O-GlcNAc modification in inclusion body myositisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DNA double-strand breaks in inclusion body myositis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

NOS-JNK-Cdk5 linkage in neurodegeneration of amyotrophic lateral sclerosis.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of MAP kinase cascades in inclusion body myositis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Relationship between motor neuron disease with basophilic inclusions and frontotemporal dementiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Contribution of iNOS for neurodegeneration in ALS and Parkinson's disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

神経変性疾患の中枢神経組織における細胞骨格蛋白と神経伝達物質の免疫組織化学的検討

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] わかりやすい内科学(第3版)(井村裕夫編)(全身性疾患に伴う神経疾患)2008

Author(s)

Publisher

Data Source

[Journal Article] Myonuclear breakdown in sporadic inclusion body myositis is accompanied by DNA double strand breaks.2011

Author(s)

Journal Title

Data Source

[Journal Article] Smad ubiquitination regulatory factor-2 in progressive supranuclear palsy.2011

Author(s)

Journal Title

Data Source

[Journal Article] Nuclear contour irregularity and abnormal transporter protein distribution in anterior horn cells in amyotrophic lateral sclerosis.2009

Author(s)

Journal Title

Data Source

[Journal Article] Intra-bone marrow-bone marrow transplantation slows disease progression and prolongs survival in G93A mutant SOD1 transgenic mice, an animal model mouse for amyotrophic lateral sclerosis.2009

Author(s)

Journal Title

Data Source

[Journal Article] The first Japanese patient with variant Creutzfeldt-Jakob disease (vCJD).2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Expression of caveolar components in primary desminopathy.2008

Author(s)

Journal Title

Data Source

[Journal Article] Histone H1 is released from myonuclei and present in rimmed vacuoles with DNA in inclusion body myositis.2008

Author(s)

Journal Title

Data Source

KUSAKA Hirofumi 日下博文

日下博文クサカヒロフミ