YAMAMOTO Kazuo 山本一男

… Alternative Names

Researcher Number	70255123
Other IDs
External Links
Affiliation (Current)	2020: 長崎大学, 医歯薬学総合研究科(医学系), 准教授
Affiliation (based on the past Project Information) *help	2020: 長崎大学, 医歯薬学総合研究科(医学系), 准教授 2014 – 2018: 長崎大学, 医歯薬学総合研究科(医学系), 准教授 2017: 長崎大学, 医歯(薬)学総合研究科, 准教授 2002 – 2004: 長崎大学, 大学院・医歯薬学総合研究科, 助教授 1999 – 2001: School of Medicine, Nagasaki University Lecturer, 大学院・医学研究科, 講師 … More
Review Section/Research Field	Principal Investigator Molecular biology / Biological Sciences / Tumor biology / Laboratory medicine / Obstetrics and gynecology / Basic Section 50010:Tumor biology-related Except Principal Investigator General medical chemistry / Experimental pathology / Virology / Pathobiological dentistry/Dental radiology / Biomolecular chemistry / Gastroenterology / Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
Keywords	Principal Investigator ミトコンドリア / 代謝 / 翻訳制御 / rRNA遺伝子 / プロモーター / 転写制御 / リンパ球 / 転写因子 / IRF / 活性調節 … More Except Principal Investigator rDNA / UBF / FM3A / MH134 / RPA40 / PAF53 / 転写因子 / IRF / NF-kappaB / IRF-3 / IFNβ / dsRNA / NDV / HT1080 / atherosclerosis / PPARγ / がん代謝 / efp / エストロゲン受容体 / リングフィンガー / Znフィンガー蛋白 / エストロゲン応答要素 / CpGアイランド・ライブラリー / NMDA受容体2型D / In situ hybrization histochemistry / 成人性白血病 / Fibroleukin / IFN-γ / Fas / RNAポリメラーゼ / 転写制御 / RNAポリメラーゼI(PolI) / PIN / ERCC3 / ペレット転写法 / RNAポリメラーゼI / 核小体 / HMG-box / NLS / 酸性ドメイン / RNA polymerase / Transcriptional Regulation / サイトカイン / インターフェロン / cytokine / interferon / transcription factor / GFP融合タンパク質 / 発現スクリーニング / in vitroリン酸化アッセイ / GFP-fusion protein / expression screening / 電離放射線 / マクロファージ / atheroselerosis / ionizing radiation / macrophage / 活性酸素種 / エピジェネティクス / 生体分子 / 癌 / Largen遺伝子 / 肝細胞癌 / Largen / ワールブルグ効果 Less

葉酸代謝に関与するアルデヒド脱水素酵素のがん抑制機能の全容解明を目指してOngoing
- Principal Investigator
  
  佐々木雅人
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
Exploring a molecular mechanism governing the metabolism to repress cancer progression depending on genetic backgroundsPrincipal InvestigatorOngoing
- Principal Investigator
  
  山本一男
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Nagasaki University
アルデヒド脱水素酵素が関与するNADPH／葉酸代謝異常と発がん・腫瘍進展機構Ongoing
- Principal Investigator
  
  佐々木雅人
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Tohoku Medical and Pharmaceutical University
細胞サイズ調節遺伝子によるワールブルグ効果の破綻を利用した肝細胞癌抑制の研究Ongoing
- Principal Investigator
  
  三馬聡
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagasaki University
Elucidation of the molecular mechanism of Fmr1-associated premature ovarian failure based on novel protein-protein interactionsPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Kazuo
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Nagasaki University
Dissecting the roles of metabolism in the development of cancer by means of the mitochondrial hyperactive model micePrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Kazuo
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor biology
- Research Institution
  Nagasaki University
リンパ球特異的転写因子IRF4の活性調節による過剰免疫応答の制御Principal Investigator
- Principal Investigator
  
  山本一男
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
Investigation of mechanism on radiation-induced atheroma
- Principal Investigator
  
  KATAYAMA Ikuo
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  NAGASAKI UNIVERSITY
Proteome Analysis for Early Diagnosis of Prion DiseasePrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Kazuo
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Nagasaki University
成人T細胞性白血病患者末梢血細胞における細胞外マトリックスの分子生物学的解析
- Principal Investigator
  
  KOHNO Tomoko
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Nagasaki University
Identification of novel factors related to induction of IFN by viral infection
- Principal Investigator
  
  KOHNO Tomoko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Nagasaki University
Role of IFN transcription factors, IRF-1, and IRF-2 in acute hepatic injury model
- Principal Investigator
  
  MATSUYAMA Toshifumi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University
エストロゲン応答性転写因子efpの機能とその作用カスケード
- Principal Investigator
  
  MURAMATSU Masami
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Saitama Medical University
rRNA遺伝子のプロモーターい結合する新規蛋白質p70の構造と機能Principal Investigator
- Principal Investigator
  
  山本一男
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Molecular biology
- Research Institution
  Saitama Medical University
Regulation Mechanisms of Ribosomal Gene in Cellular Growth and Differentiation
- Principal Investigator
  
  MURAMATSU Masami
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Saitama Medical School

All 2018 2016 2015

All Journal Article Presentation Book

[Book] 実験医学2016年9月増刊号2016
- Author(s)
  山本一男
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-26640082
[Journal Article] Intracellular redox status controls spherogenicity, an in vitro cancer stem cell marker, in thyroid cancer cell lines2018
- Author(s)
  Shimamura M, Yamamoto K, Kurashige T, Nagayama Y
- Journal Title
  
  Experimental Cell research
  
  Volume: 370 Issue: 2 Pages: 699-707
- DOI
  10.1016/j.yexcr.2018.07.036
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07235, KAKENHI-PROJECT-16K00548, KAKENHI-PROJECT-17K16167, KAKENHI-PROJECT-16H06276
[Journal Article] 哺乳類の細胞サイズを規定する分子基盤2016
- Author(s)
  山本一男
- Journal Title
  
  実験医学
  
  Volume: 34 Pages: 217-222
- Data Source
  KAKENHI-PROJECT-16K15709
[Journal Article] Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio2015
- Author(s)
  M Itsumi, S Inoue, AJ Elia, K Murakami, M Sasaki, EF Lind, D Brenner, IS Harris, IIC Chio, S Afzal, RA Cairns, DW Cescon, AR Elford, J Ye, PA Lang, WY Li, A Wakeham, GS Duncan, J Haight, A You-Ten, B Snow, K Yamamoto, PS Ohashi, TW Mak
- Journal Title
  
  Cell Death & Differentiation
  
  Volume: 22 Pages: 1837-1845
- DOI
  10.1038/cdd.2015.38
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20095, KAKENHI-PROJECT-26640082
[Journal Article] 細胞の大きさを規定する分子基盤2015
- Author(s)
  山本一男
- Journal Title
  
  化学と生物
  
  Volume: 53 Pages: 141-142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26640082
[Journal Article] Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression2015
- Author(s)
  Harris IS, Treloar AE, Inoue S, Sasaki M, Gorrini C, Lee KC, Yung KY, Brenner D, Knobbe-Thomsen CB, Cox MA, Elia A, Berger T, Cescon DW, Adeoye A, Brüstle A, Molyneux SD, Mason JM, Li WY, Yamamoto K, Wakeham A, Berman HK, Khokha R, Done SJ, Kavanagh TJ, Lam CW, Mak TW.
- Journal Title
  
  Cancer Cell
  
  Volume: 27 Pages: 211-222
- DOI
  10.1016/j.ccell.2014.11.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26640082
[Presentation] A mechanism of cell size regulation and its readout governed by Largen2016
- Author(s)
  Kazuo Yamamoto
- Organizer
  EMBO Workshop
- Place of Presentation
  Joachimsthal, Germany
- Year and Date
  2016-09-14
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26640082
[Presentation] A molecular basis of mammalian cell size control2016
- Author(s)
  Kazuo Yamamoto, Masato Sasaki, Ivan Topisirovic, Mitsuhiko Ikura, Nahum Sonenberg, Tak W. Mak
- Organizer
  CDB Symposium 2016
- Place of Presentation
  理化学研究所多細胞システム形成研究センター（兵庫県・神戸市）
- Year and Date
  2016-03-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26640082
[Presentation] A mechanism of cell size regulation and its readout governed by Largen2016
- Author(s)
  Kazuo Yamamoto
- Organizer
  The EMBO Workshop on Cell Size Regulation
- Place of Presentation
  ヨアヒムシュタール（ドイツ）
- Year and Date
  2016-09-14
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15709
[Presentation] 細胞の大きさを制御する遺伝子ネットワークの抽出2015
- Author(s)
  山本一男、Susan McCracken、Tak W. Mak
- Organizer
  第38回日本分子生物学会年会　第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26640082

1. MATSUYAMA Toshifumi (30165922)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. KOHNO Tomoko (60284684)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. MURAMATSU Masami (10035454)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. NOGI Yasuhisa (60101937)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 佐々木雅人 (30396527)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. MAKINO Yasutaka (20240989)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TAMURA Taka-aki (30112692)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SUZUKI Toshiya (90216416)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KOJIMA Chojiro (50333563)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KATAMINE Shigeru (40161062)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KATAYAMA Ikuo (80295089)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. HOTOKEZAKA Yuka (10244089)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. NAKAMURA Takashi (30172406)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 奥田晶彦 (60201993)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 三馬聡 (30437892)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. NAGAYAMA Yuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. SHIMAMURA Mika

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. 蔵重智美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 逸見百江

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMAMOTO Kazuo 山本 一男

山本 一男 ヤマモト カズオ

Research Projects

Research Products

Co-Researchers

葉酸代謝に関与するアルデヒド脱水素酵素のがん抑制機能の全容解明を目指してOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploring a molecular mechanism governing the metabolism to repress cancer progression depending on genetic backgroundsPrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アルデヒド脱水素酵素が関与するNADPH／葉酸代謝異常と発がん・腫瘍進展機構Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞サイズ調節遺伝子によるワールブルグ効果の破綻を利用した肝細胞癌抑制の研究Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the molecular mechanism of Fmr1-associated premature ovarian failure based on novel protein-protein interactionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Dissecting the roles of metabolism in the development of cancer by means of the mitochondrial hyperactive model micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

リンパ球特異的転写因子IRF4の活性調節による過剰免疫応答の制御Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of mechanism on radiation-induced atheroma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Proteome Analysis for Early Diagnosis of Prion DiseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

成人T細胞性白血病患者末梢血細胞における細胞外マトリックスの分子生物学的解析

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Identification of novel factors related to induction of IFN by viral infection

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of IFN transcription factors, IRF-1, and IRF-2 in acute hepatic injury model

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

エストロゲン応答性転写因子efpの機能とその作用カスケード

Principal Investigator

Project Period (FY)

Research Category

YAMAMOTO Kazuo 山本一男

山本一男ヤマモトカズオ