Mukai Jun 向井淳

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MUKAI Jun 向井淳

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Researcher Number	70263019
Other IDs	https://orcid.org/0000-0003-2065-4784
Affiliation (Current)	2025: 筑波大学, プレシジョン・メディスン開発研究センター, 教授
Affiliation (based on the past Project Information) *help	2019 – 2025: 筑波大学, プレシジョン・メディスン開発研究センター, 教授 1994 – 1995: 三重大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 52030:Psychiatry-related / Medium-sized Section 52:General internal medicine and related fields / Basic Section 46010:Neuroscience-general-related Except Principal Investigator Basic Section 52030:Psychiatry-related / 応用薬理学・医療系薬学 / General pharmacology
Keywords	Principal Investigator クロマチン / エピゲノム / 統合失調症 / クロマチンリモデリング / H3K4メチレーション / 作業記憶 / Setd1a / ヒストンメチレーション / シナプス / URVs … More / クロマチン高次構造 / マウスモデル / エピジェネティクス / 神経発達症 / オルガノイド / rare variants / LSD1阻害薬 / 2光子顕微鏡 / カルシウムイメージング / 皮質アンサンブル / working memory / schizophrenia / chromatin remodeling / histone methylation / 神経発達障害 / 22q11.2欠失症候群 / SETD1A / ヒストンリモデリング … More Except Principal Investigator PAF / S100L / cDNAクローニング / 遺伝子発現 / 分子生物学 / 分化制御 / 心筋 / S100C / メタボロミクス / 脳オルガノイド / メタボローム / rare variant / 疾患マウスモデル / 統合失調症 / Ca2+-sensitivity / Actin / PKC / Contraction / Phosphorylation / Calcium ion / Smooth muscle / Calponin / シグナル伝達 / 血管収縮 / 冠状動脈 / 繰り返し構造 / アクチン結合 / プロテインキナーゼC / 収縮 / プロティンキナーゼC / アクチン / カルシウム感受性 / カルシウム / 平滑筋 / リン酸化反応 / カルポニン / Signal transduction / Ca^<2+>-binding protein / S100 protein / Chemotaxis / Eosinophil / Leucocyte / 白血球活性化因子 / 細胞内情報伝達 / S100蛋白質 / 好酸球 / 走化性 / 白血球 / ラフト / 転写因子 / ラット / S100蛋白質ファミリー Less

統合失調症に関連するURVsによる病態メカニズムの解明Principal Investigator
- Principal Investigator
  
  向井淳
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  University of Tsukuba
統合失調症のエピゲノム分子病態Principal Investigator
- Principal Investigator
  
  向井淳
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  University of Tsukuba
Brain Metabolome Atlas in Schizophrenia Mouse Models
- Principal Investigator
  
  佐藤孝明
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  University of Tsukuba
Elucidation of pathological neural circuit formation mechanism for early therapeutic intervention of cognitive dysfunction in psychiatric disease.Principal Investigator
- Principal Investigator
  
  向井淳
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  University of Tsukuba
Decifering the role of histone methyltransferase Setd1a in schizophreniaPrincipal Investigator
- Principal Investigator
  
  Mukai Jun
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  University of Tsukuba
心筋細胞の分化機構に関する分子生物学的研究
- Principal Investigator
  
  田中利男
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Mie University
Novel all signoling in vascular smooth muscle
- Principal Investigator
  
  NAKA Michiko
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Mie University
心筋細胞の分化制御機構に関する分子生物学的研究
- Principal Investigator
  
  TANAKA Toshio
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Mie University
Molecular Pharmacology of Leucocyte Activation
- Principal Investigator
  
  TANAKA Toshio
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Mie University

All 2020 2019

All Journal Article Presentation

[Journal Article] Aberrant Cortical Ensembles and Schizophrenia-like Sensory Phenotypes in Setdla+/-Mice.2020
- Author(s)
  Hamm JP, Shymkiv Y, Mukai J, Gogos JA, Yuste R.
- Journal Title
  
  Biological Psychiatry
  
  Volume: - Issue: 3 Pages: 215-223
- DOI
  10.1016/j.biopsych.2020.01.004
- Description
  In press
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19H03320
[Journal Article] Recapitulation and Reversal of Schizophrenia-Related Phenotypes in Setd1a-Deficient Mice2019
- Author(s)
  Mukai Jun、Cannav? Enrico、Crabtree Gregg W.、Sun Ziyi、Diamantopoulou Anastasia、Thakur Pratibha、Chang Chia-Yuan、Cai Yifei、Lomvardas Stavros、Takata Atsushi、Xu Bin、Gogos Joseph A.
- Journal Title
  
  Neuron
  
  Volume: 104 Issue: 3 Pages: 471-487
- DOI
  10.1016/j.neuron.2019.09.014
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06254, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19H03320
[Presentation] Deciphering the role of the histone methyltransferase SETD1A in Schizophrenia2019
- Author(s)
  向井　淳
- Organizer
  日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19H03320

1. NAKA Michiko (10093139)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. TANAKA Toshio (00135443)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 松島聡 (50252367)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 佐藤孝明 (30225958)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 福田茉由 (60894798)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 高田篤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Mukai Jun 向井 淳

MUKAI Jun 向井 淳

Research Projects

Research Products

Co-Researchers

統合失調症に関連するURVsによる病態メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

統合失調症のエピゲノム分子病態Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Brain Metabolome Atlas in Schizophrenia Mouse Models

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of pathological neural circuit formation mechanism for early therapeutic intervention of cognitive dysfunction in psychiatric disease.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Decifering the role of histone methyltransferase Setd1a in schizophreniaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

心筋細胞の分化機構に関する分子生物学的研究

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Novel all signoling in vascular smooth muscle

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

心筋細胞の分化制御機構に関する分子生物学的研究

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Molecular Pharmacology of Leucocyte Activation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Aberrant Cortical Ensembles and Schizophrenia-like Sensory Phenotypes in Setdla+/-Mice.2020

Author(s)

Journal Title

DOI

Description

Data Source

[Journal Article] Recapitulation and Reversal of Schizophrenia-Related Phenotypes in Setd1a-Deficient Mice2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] Deciphering the role of the histone methyltransferase SETD1A in Schizophrenia2019

Author(s)

Organizer

Data Source

Mukai Jun 向井淳

MUKAI Jun 向井淳