Horikawa Manabu 堀川学

… Alternative Names

堀川学ホリカワマナブ

HORIKAWA Manabu 堀川学

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Researcher Number	70270569
Other IDs
External Links
Affiliation (Current)	2025: 公益財団法人サントリー生命科学財団, 生物有機科学研究所・構造生命科学研究部, 特任研究員
Affiliation (based on the past Project Information) *help	2023: 公益財団法人サントリー生命科学財団, 生物有機科学研究所・構造生命科学研究部, 研究員 2019 – 2021: 公益財団法人サントリー生命科学財団, 生物有機科学研究所・構造生命科学研究部, 研究員 2008 – 2009: サントリー生物有機科学研究所, 研究員 2008: 東邦大学, サントリー生物有機科学研究所, 研究員 2006 – 2007: Suntory Institure for Bioorganic Research, Reseacher, 研究員 … More 2004 – 2006: サントリー生物有機科学研究所, 研究員 2005: (財)サントリー生物有機科学研究所, その他, 研究員 2004: 財団法人サントリー生物有機科学研究所, 研究員 1995: (財)サントリー生物有機科学研究所, その他部局等, 研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 38040:Bioorganic chemistry-related / Living organism molecular science / Bioorganic chemistry Except Principal Investigator Infectious disease medicine / 膠原病・アレルギー・感染症内科学 / Biological Sciences
Keywords	Principal Investigator リグナン / オイルボディ / autoinducer / ゴマ植物 / セサミン / リパーゼ阻害活性 / オイルボディ蛋白質 / セサミン代謝物 / エピセサミノン / セサミノール … More / ゴマリグナン / オイルボディ構成タンパク質 / RNA-seq / 脂質代謝 / セサミン酸化酵素 / IL-8 / tetramic acid / apoptosis / molecular probe / molecular modeling / Pseudomonas aeruginosa / quorum-sensing / N-3-oxo-dodecanoyl-L-homoserine lactone / 緑濃菌 / ホモセリンラクトン / テトラミン酸 / アポトーシス / 自己誘導因子 / 分子プローブ / 分子モデリング / Autoinducer / 緑膿菌 / クオラムセンシング / α-(ヒドロキシメチル)フェニルアラニン / α-(ヒドロキシメチル)アスパラギン酸 / グルタメートレセプター / 分子内不斉Strecker反応 / α,α-二置換 α-アミノ酸 … More Except Principal Investigator 細菌間情報伝達 / 治療法 / 病原因子 / 感染症 / Quorum-sensing / 緑膿菌 / ワクチン / 新規治療法 / 新規治療戦略 / Quorum-sensing機構 / マクロライド / Autoinducer Less

植物におけるリグナン類の生理機能の解明Principal Investigator
- Principal Investigator
  
  堀川学
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Suntory Foundation for Life Sciences
Phisiological Function of Lignans in PlantsPrincipal Investigator
- Principal Investigator
  
  Horikawa Manabu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Suntory Foundation for Life Sciences
細菌間情報伝達物質を用いた新しい感染症治療に関する研究
- Principal Investigator
  
  舘田一博
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Infectious disease medicine
- Research Institution
  Toho University
Molecular mechanisms of cell-to-cell signaling in bacteria, and its manipulation for novel therapeutic strategies
- Principal Investigator
  
  TATEDA Kazuhiro
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Toho University
細菌の情報伝達機構をターゲットとした新しい感染症治療法に関する研究
- Principal Investigator
  
  TATEDA Kazuhiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Toho University
Studies on the control of cell-cell signal transduction based on bacterial quorum-sensing systemPrincipal Investigator
- Principal Investigator
  
  HORIKAWA Manabu
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Living organism molecular science
- Research Institution
  Suntory Institute for Bioorganic Research
α,α-二置換 α-アミノ酸の分子設計Principal Investigator
- Principal Investigator
  
  堀川学
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Suntory Institute for Bioorganic Research

All 2020 2010 2009 2008 2007 2006 2004

All Journal Article Presentation

[Journal Article] (+)-Sesamin-oxidising CYP92B14 shapes specialised lignan metabolism in sesame2020
- Author(s)
  Erisa Harada, Jun Murata, Eiichiro Ono, Hiromi Toyonaga, Akira Shiraishi, Kosuke Hideshima, Masayuki P. Yamamoto, Manabu Horikawa
- Journal Title
  
  The Plant Journal
  
  Volume: 104 Issue: 4 Pages: 1117-1128
- DOI
  10.1111/tpj.14989
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05857
[Journal Article] Anti-Clostridium difficile potential of tetramic acid derivatives from Pseudomonas aeruginosa quorum-sensing autoinducers.2010
- Author(s)
  Ueda C, Tateda K, Horikawa M, Kimura S, Ishii Y, Nomura K, Yamada K, Suematsu T, Inoue Y, Ishiguro M, Miyairi S, Yamaguchi K.
- Journal Title
  
  Antimicrob Agents Chemother 54
  
  Pages: 683-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390294
[Journal Article] Pseudomonas aeruginosa Las quorum sensing autoinducer suppress growth and biofilm production in Legionella species.2009
- Author(s)
  Kimura S, Tateda K, Ishii Y, Horikawa M, Miyairi S, Gotoh N, Ishiguro M, Yamaguchi K.
- Journal Title
  
  Microbiology 155
  
  Pages: 1934-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390294
[Journal Article] Suppression of Pseudomonas aeruginosa quorum-sensing systems by macrolides: a promising strategy or an oriental mystery2007
- Author(s)
  Tateda K, Ishii Y, Kimura S, Horikawa M, Miyairi S, Yamaguchi K.
- Journal Title
  
  J Infect Chemother 13
  
  Pages: 357-367
- NAID
  10020023264
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390294
[Journal Article] Synthesis of Pseudomonas quorum-sensing autoinducer analogs and structural entities required for induction of apoptosis in macrophages.2006
- Author(s)
  Horikawa M, Takeda K et al.
- Journal Title
  
  Bioorg Med Chem Lett. 16・8
  
  Pages: 2130-3
- Data Source
  KAKENHI-PROJECT-18390294
[Journal Article] Synthesis of Pseudomonas quorum-sensing autoinducer analogs and structural entities required for induction of apoptosis in macrophages2006
- Author(s)
  Manabu Horikawa
- Journal Title
  
  Bioorganic ＆ Medicinal Chemistry Letters 16(8)
  
  Pages: 2130-2133
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16510175
[Journal Article] Synthesis of Pseudomonas quorum-sensing autoinducer analogs and structural entities required for induction of apoptosis in macrophages.2006
- Author(s)
  Horikawa M. et al.
- Journal Title
  
  Bioorg Med Chem Lett.2006 Feb 3 [Epub ahead of print]
- Data Source
  KAKENHI-PROJECT-16017297
[Journal Article] Immunization with 3-oxododecanoyl-L-homoserine lactone-protein conjugate protects mice from lethal Pseudomonas aeruginosa lung infection.2006
- Author(s)
  Miyairi S, Tateda K, Fuse ET, Ueda C, Saito H, Takabatake T, Ishii Y, Horikawa M, Ishiguro M, Standiford TJ, Yamaguchi K.
- Journal Title
  
  J Med Microbiol 55
  
  Pages: 1381-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390294
[Journal Article] Synthesis of Pseudomonas quorum-sensing autoinducer analogs and structural entities required for induction of apoptosis in macrophages.2006
- Author(s)
  Horikawa M, Tateda K, Tuzuki E, Ishii Y, Ueda C, Takabatake T, Miyairi S, Yamaguchi K, Ishiguro M.
- Journal Title
  
  Bioorg Med Chem Lett 16
  
  Pages: 2130-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390294
[Journal Article] Synthesis of Pseudomonas quorum-sensing autoinducer analogs and structural entities required for induction of apoptosis in macrophages2006
- Author(s)
  Manabu Horikawa
- Journal Title
  
  Bioorganic ＆ Medicinal Chemistry Letters 16・8
  
  Pages: 2130-2133
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16510175
[Journal Article] Synthesis of Pseudomonas quorum-sensing autoinducer analogs and structural entities required for induction of apoptosis in macrophages2006
- Author(s)
  Horikawa, M., Tateda, K., et al.
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters 16・8
  
  Pages: 2130-2133
- Data Source
  KAKENHI-PROJECT-16510175
[Journal Article] クオラムセンシング阻害薬の可能性2004
- Author(s)
  堀川学
- Journal Title
  
  最新医学 59・12
  
  Pages: 2590-2597
- Data Source
  KAKENHI-PROJECT-16510175
[Journal Article] クオラムセンシング機構阻害剤 : その理論と方向性2004
- Author(s)
  堀川学
- Journal Title
  
  臨床と微生物 31・3
  
  Pages: 261-270
- NAID
  10013595980
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16510175
[Journal Article] クオラムセンシング機構阻害剤:その理論と方向性2004
- Author(s)
  堀川学
- Journal Title
  
  臨床と微生物 31・3
  
  Pages: 261-270
- NAID
  10013595980
- Data Source
  KAKENHI-PROJECT-16510175
[Journal Article] クオラムセンシング阻害剤の可能性2004
- Author(s)
  堀川学
- Journal Title
  
  最新医学 59・12
  
  Pages: 2590-2597
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16510175
[Journal Article] Feasibility of quorum-sensing inhibitors2004
- Author(s)
  Manabu Horikawa
- Journal Title
  
  Medical Frontline 59(12)
  
  Pages: 2590-2597
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16510175
[Journal Article] Inhibitors for quorum-sensing systems : their concepts and strategies2004
- Author(s)
  Manabu Horikawa
- Journal Title
  
  Clinical Microbiology 31(3)
  
  Pages: 261-270
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16510175
[Presentation] Antibacterial Potential of Tetramic Acid Derived from Pseudomonas Quorum-Sensing Autoinducer against Clostridium difficile and Clostridium perfringens.2008
- Author(s)
  Ueda C, Tateda K, Kimura S, Ishii Y, Horikawa M, Yamaguchi K.
- Organizer
  48rd ICAAC
- Place of Presentation
  Washington DC
- Year and Date
  2008-10-15
- Data Source
  KAKENHI-PROJECT-18390294
[Presentation] Antibacterial Potential of Tetramic Acid Derived from Pseudomonas Quorum-Sensing Autoinducer against Clostridium difficile and Clostridium perfringens2008
- Author(s)
  Ueda C, Tateda K, Kimura S, Ishii Y, Horikawa M, Yamaguchi K.
- Organizer
  48^<rd> ICAAC
- Place of Presentation
  Washington DC
- Data Source
  KAKENHI-PROJECT-18390294
[Presentation] Antibacterial potential of Pseudomonas aeruginosa quorum-sensing autoinducers and their degradation products, tetramic acids, against Clostridium difficile.2007
- Author(s)
  Ueda C, Tateda K, Horikawa M, Kimura S, Ishii Y, Yamaguchi K
- Organizer
  47rd ICAAC
- Place of Presentation
  Chicago
- Year and Date
  2007-09-17
- Data Source
  KAKENHI-PROJECT-18390294
[Presentation] Roles of Pseudomonas aeruginosa autoinducers and their degradation products, tetramic acids, in bacterial survival and behavior in ecological niches.2007
- Author(s)
  Hosono N, Tateda K, Ueda C, Horikawa M, Yamaguchi K
- Organizer
  47rd ICAAC
- Place of Presentation
  Chicago
- Year and Date
  2007-09-17
- Data Source
  KAKENHI-PROJECT-18390294

1. TATEDA Kazuhiro (20236558)

# of Collaborated Projects: 4 results

# of Collaborated Products: 11 results
2. ISHII Yoshikazu (90246695)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
3. MIYAIRI Shinichi (50209855)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. KIMURA Soichiro (60408870)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
5. FUKUSHIMA Jun (00181256)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. GOTO Naomasa (30121560)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Horikawa Manabu 堀川 学

堀川 学 ホリカワ マナブ

HORIKAWA Manabu 堀川 学

Research Projects

Research Products

Co-Researchers

植物におけるリグナン類の生理機能の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Phisiological Function of Lignans in PlantsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

細菌間情報伝達物質を用いた新しい感染症治療に関する研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms of cell-to-cell signaling in bacteria, and its manipulation for novel therapeutic strategies

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細菌の情報伝達機構をターゲットとした新しい感染症治療法に関する研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies on the control of cell-cell signal transduction based on bacterial quorum-sensing systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

α,α-二置換 α-アミノ酸の分子設計Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] (+)-Sesamin-oxidising CYP92B14 shapes specialised lignan metabolism in sesame2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anti-Clostridium difficile potential of tetramic acid derivatives from Pseudomonas aeruginosa quorum-sensing autoinducers.2010

Author(s)

Journal Title

Data Source

[Journal Article] Pseudomonas aeruginosa Las quorum sensing autoinducer suppress growth and biofilm production in Legionella species.2009

Author(s)

Journal Title

Data Source

[Journal Article] Suppression of Pseudomonas aeruginosa quorum-sensing systems by macrolides: a promising strategy or an oriental mystery2007

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Synthesis of Pseudomonas quorum-sensing autoinducer analogs and structural entities required for induction of apoptosis in macrophages.2006

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis of Pseudomonas quorum-sensing autoinducer analogs and structural entities required for induction of apoptosis in macrophages2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Synthesis of Pseudomonas quorum-sensing autoinducer analogs and structural entities required for induction of apoptosis in macrophages.2006

Author(s)

Journal Title

Data Source

[Journal Article] Immunization with 3-oxododecanoyl-L-homoserine lactone-protein conjugate protects mice from lethal Pseudomonas aeruginosa lung infection.2006

Horikawa Manabu 堀川学

堀川学ホリカワマナブ

HORIKAWA Manabu 堀川学