HATA Hiroyuki 畑裕之

Researcher Number	70271129
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2009: 熊本大学, 医学部・附属病院, 講師 2007: 熊本大学, 医学部附属病院, 講師 2007: Kumamoto University of Medicine, DEPARTMENT of Hematology, 講師 2006: 熊本大学, 大学院医学薬学研究部, 講師 2005: 熊本大学, 医学部附属病院, 講師 … More 2004: 熊本大学, 大学院・医学薬学研究部, 講師 1998: 熊本大学, 医学部付属病院, 助手 1995 – 1997: 熊本大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Hematology Except Principal Investigator Hematology / Biological Sciences
Keywords	Principal Investigator アポトーシス / 多発性骨髄腫 / Bax / Bcl-2 / 蛋白合成阻害剤 / Bcl-2ファミリー / Bcl-X / cycloheximide / サイトカイン / モノクローナル抗体 / Apo-1(CD95) / Fas … More Except Principal Investigator … More PU.1 / 多発性骨髄腫 / TRAIL / HAM / ATL / HTLV-I / アポトーシス / Apoptosis / Demethylation Agents / Methylation / Multiple Myeloma / p21 / IRF7 / 脱メチル化剤 / メチル化 / Egypt / Florida / Indonesia / Costa Rica / エジプト / フロリダ / インドネシア / コスタリカ / 予後 / IRF4 / 血液腫瘍学 / Flt3-ITD / CD34 / 白血病幹細胞 / アルギニン / 高心拍出性心不全 / NO合成酵素 / 一酸化窒素 / 成人T細胞白血病 / 造血器腫瘍 Less

Stratification of multiple myeloma according to PU.1 expression level
- Principal Investigator
  
  TATETSU Hiro
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Kumamoto University
Downregulation of PU.1 is required for myeloma cell growth
- Principal Investigator
  
  OKUNO Yutaka
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kumamoto University
白血病モデルマウスよりの白血病幹細胞の同定とその性状の解析
- Principal Investigator
  
  OKUNO Yutaka
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
ヒト造血器腫瘍によるNO合成とその意義:NOによる病態修飾と腫瘍増殖促進
- Principal Investigator
  
  MATSUZAKI Hiromitsu
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
骨髄腫細胞に発現するアポトーシス関連リン酸化蛋白質のクローニングPrincipal Investigator
- Principal Investigator
  
  畑裕之
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Hematology
- Research Institution
  Kumamoto University
骨髄腫細胞におけるシクロヘキシミドで誘導されるアポトーシスの解析Principal Investigator
- Principal Investigator
  
  畑裕之
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Hematology
- Research Institution
  Kumamoto University
Comparative Study of ATL and HTLV-I Related Diseases
- Principal Investigator
  
  YAMAGUCHI Kazunari
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kumamoto University School of Medicine
Fas以外の新しいアポトーシス誘導抗原のクローニングPrincipal Investigator
- Principal Investigator
  
  畑裕之
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Hematology
- Research Institution
  Kumamoto University

All 2009 2007 2006 2005

All Journal Article Presentation

[Journal Article] PU. 1 induces apoptosis in myeloma cells through direct transactivation of TRAIL2009
- Author(s)
  Ueno S, Tatetsu H, Hata H, Iino T, Niiro H, Akashi K, Tenen DG, Mitsuya H, Okuno Y
- Journal Title
  
  Oncogene 28(46)
  
  Pages: 4116-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790677
[Journal Article] Molecular mechanisms inhibiting proliferation of myeloma cells2007
- Author(s)
  Kikukawa, Y., Okuno Y., Hata, H
- Journal Title
  
  Nippon Rinsho 65 : 2
  
  Pages: 2195-2201
- NAID
  40015721736
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591002
[Journal Article] Down-regulation of PU.1 by Methylation of Distal Regulatory Elements and the Promoter Is Required for Myeloma Cell Growth2007
- Author(s)
  Tatetsu, H, Ueno, S, Hata H., Yamada, Takeya, M. Mitsuya, H., Temen, D.G., Okuno, Y
- Journal Title
  
  Cancer Res 67
  
  Pages: 5328-5336
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591002
[Journal Article] Activation of the endoplasmic reticulum stress pathway is associated with survival of myeloma cells2006
- Author(s)
  Nakamura, M. Gotoh, T. Okuno, Y., Tatetsu, H., Sonoki, T., Uneda, S., Mori, M., Mitsuya, H., Hata, H
- Journal Title
  
  Leuk Lymphoma 47
  
  Pages: 531-539
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591002
[Journal Article] Dehydroxymethylepoxyquinomicin, a novel nuclear factor{kappa}B inhibitor, induces apoptosis in multiple myeloma cells in an I{kappa}B{alpha}-independent manner.2005
- Author(s)
  Tatetsu, H., Okuno, Y., Nakamura, M., Matsuno, F., Sonoki, T., Taniguchi, I., Uneda, S., Umezawa, K., Mitsuya, H., Hata, H
- Journal Title
  
  Mol Cancer Ther 4
  
  Pages: 1114-1120
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591002
[Presentation] Microarray analysis of PU.l-induced growth arrest and apoptosis of myeloma cell lines.2007
- Author(s)
  Shikiko, Ueno, Hiro, Tatetsu, Naoko, Harada, Hiroyuki, Hata, Tadafumi, lino, Hiroaki, Niiro, Koichi, Akashi, G., Daniel, Tenen, Hiroaki, Mitsuya, Yutaka, Okuno
- Organizer
  American Society of Hemetology, Sunday
- Place of Presentation
  Georgia World Congress Center Atlanta Georgia
- Year and Date
  2007-12-09
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591002
[Presentation] PU.1 is downregulated in a subset of multiple myeloma by the methylation of its "17 kb upstream regulatory region and the promoter.2006
- Author(s)
  Yutaka, Okuno, Hiro, Tatetsu, Shikiko, Ueno, Hiroyuki, Hata, Yasuhiro, Yamada, Motohiro, Takeya, Tadafumi, lino, Koichi, Akashi, Daniel, G., Tenen, Hiroaki, Mitsuya
- Organizer
  American Society of Hemetology
- Place of Presentation
  Orange County Convention Center Orlando, Florida
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591002
[Presentation] Downregulation of PU. l is required for subtype of multiple myeloma.2005
- Author(s)
  Hiro, Tatetsu, Hiroyuki, Hata, Yasuhiro, Yamada, Hiroaki, Mitsuya, Yutaka, Okun
- Organizer
  American Society of Hemetology
- Place of Presentation
  Georgia World Congress Center Atlanta, Georgia
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591002

1. OKUNO Yutaka (80363539)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
2. MATSUZAKI Hiromitsu (30136725)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. TATETSU Hiro (00433029)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. UENO Shikiko (40571047)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. YAMAGUCHI Kazunari (20128325)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MOCHIZUKI Manabu (10010464)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MATSUOKA Masao (10244138)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 麻生範雄 (50175171)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. YANTO Lunard

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. LUNARDI-ISKANDAR Yanto

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. ABRAHAM Blan

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HATA Hiroyuki 畑 裕之

Research Projects

Research Products

Co-Researchers

Stratification of multiple myeloma according to PU.1 expression level

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Downregulation of PU.1 is required for myeloma cell growth

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

白血病モデルマウスよりの白血病幹細胞の同定とその性状の解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒト造血器腫瘍によるNO合成とその意義:NOによる病態修飾と腫瘍増殖促進

Principal Investigator

Project Period (FY)

Research Category

Research Institution

骨髄腫細胞に発現するアポトーシス関連リン酸化蛋白質のクローニングPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

骨髄腫細胞におけるシクロヘキシミドで誘導されるアポトーシスの解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Comparative Study of ATL and HTLV-I Related Diseases

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Fas以外の新しいアポトーシス誘導抗原のクローニングPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] PU. 1 induces apoptosis in myeloma cells through direct transactivation of TRAIL2009

Author(s)

Journal Title

Data Source

[Journal Article] Molecular mechanisms inhibiting proliferation of myeloma cells2007

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] Down-regulation of PU.1 by Methylation of Distal Regulatory Elements and the Promoter Is Required for Myeloma Cell Growth2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Activation of the endoplasmic reticulum stress pathway is associated with survival of myeloma cells2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Dehydroxymethylepoxyquinomicin, a novel nuclear factor{kappa}B inhibitor, induces apoptosis in multiple myeloma cells in an I{kappa}B{alpha}-independent manner.2005

Author(s)

Journal Title

Description

Data Source

[Presentation] Microarray analysis of PU.l-induced growth arrest and apoptosis of myeloma cell lines.2007

Author(s)

Organizer

Place of Presentation

Year and Date

HATA Hiroyuki 畑裕之