Murozono Michihiro 室園美智博

… Alternative Names

MUROZONO MICHIHIRO 室園美智博

MUROZONO Mitihiro 室園美智博

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Researcher Number	70276947
Other IDs
External Links
Affiliation (Current)	2025: 東京医科大学, 医学部, 臨床准教授
Affiliation (based on the past Project Information) *help	2014 – 2016: 東京医科大学, 医学部, 准教授 2004 – 2010: Tokyo Medical University, Medicine, lecturer, 医学部, 講師 2000 – 2004: 東京医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Anesthesiology/Resuscitation studies / Anesthesiology/Resuscitation studies / Anesthesiology Except Principal Investigator Anesthesiology/Resuscitation studies / Anesthesiology/Resuscitation studies
Keywords	Principal Investigator 脳虚血 / P-glycoprotein / Brain ischemia / ノックアウトマウス / BBB / PACAP / VIP / mdrla / mdr1a / blood-brain barrier … More / knockout mouse / 局所脳虚血 / Apoptosis / Knockout mouse / Cell adhesion molecule / アポトーシス / 細胞接着分子 / 脳内トランスポーター / マウス / P-glucoprotein / サイトカイン / 血液脳関門 … More Except Principal Investigator イソフルレン / NR2 / NMDA / CaMKII / 吸入麻酔薬 / cerebral ischemia / 脳虚血 / セボフルレン / PKCγ / PKC-γ / プロポフォール / phospho-tyrosine / neuroprotecition / immuno-precipitation / inhalation anesthetics / チロシンリン酸化 / NMDAレセプター / 免疫沈降 / リン酸化チロシン / 脳保護作用 / 免疫沈降法 / phospho-CaMKII / CaMKII-_α / PKC-_Y / Propofol / Midazoram / Sevoflurane / Isoflurane / トランスロケーション / CaMkIIα / リン酸化CaMKII / CaMKII-α / ミダゾラム / Transition Pore / mitochondrial Permeability / Cytochrome C / Cyclosporin A / mdrla knockoutmice / Mitochondrial Permeability Transition Pore (6) / mdr1aノックアウトマウス / Mitochondrial Permeability Transition Pore / mdrlaノックアウトマウス / Mitochondrial Permeability Tansition Pore / サイトクロームC / サイクロスポリンA / Mdrlaノックアウトマウス / リン酸化PKCγ / リン酸化PKC-γ / セボフルラン / イソフルラン Less

Search of the effective cerebroprotection method in cerebral ischaemia which utilized brain environment derived from a transporterPrincipal Investigator
- Principal Investigator
  
  MUROZONO MICHIHIRO
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Tokyo Medical University
The study of a new target for the effects of volatile anesthetics by immunoblotting.
- Principal Investigator
  
  SEKINE Syusuke, MATSUMOTO Shohei
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Tokyo Medical University
The elucidation of the intracerebral transporter control to lead the new cerebroprotection methodPrincipal Investigator
- Principal Investigator
  
  MUROZONO Michihiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Tokyo Medical University
A research of new cerebroprotection method discovered from cross talk among intracerebral compartmentsPrincipal Investigator
- Principal Investigator
  
  MUROZONO Michihiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Tokyo Medical University
The novel analyzing assay for neuroprotection of the inhalation anesthetics by immuno-precipitation and the protein kinases related cerebral ischemia.
- Principal Investigator
  
  MATSUMOTO Shohei
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Tokyo Medical University
Neuroprotective effects of inhalation anesthetics based on the analysis of the signal transduction related to ubiquitous protein kinases.
- Principal Investigator
  
  MATSUMOTO Shohei
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Tokyo Medical University
Neuroimmunologic research of endogenous and exogenous protection on brain, taking account of the meaning of the BBB's existencePrincipal Investigator
- Principal Investigator
  
  MUROZONO Michihiro
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Tokyo Medical University
Investigation into the cross-talk of cell adhesion molecule in the brain on the mechanism, of neuronal protectionPrincipal Investigator
- Principal Investigator
  
  MUROZONO Michihiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Tokyo Medical University
Neuroprotective effect of cyosporinA. (Study for mitochordrial permeability transition pore and cytochromeC)
- Principal Investigator
  
  MATSUMOTO Shohei
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Tokyo Medical University

All 2011 2010 2009 2008 2007 2005 2004 Other

All Journal Article Presentation

[Journal Article] Effects of different types of aneathetic arents on cellular PKC γ dynamics in mouse brain2011
- Author(s)
  Akiko Takeda, Ryoichi Miyashita, Takeo Nagura, Shusuke Sekine, Michihiro Murozono, Shohei Matsumoto, Hiroyuki Uchino
- Journal Title
  
  Pharmacology 87巻
  
  Pages: 180-186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591817
[Journal Article] Effects of Differential Types of Anesthetic Agents on Cellular Protein Kinase C-γ Dynamics in Mouse Brain2011
- Author(s)
  Akiko Takeda, Ryoichi Miyashita, Takeo Nagura, Shusuke Sekine, Michihiro Murozono, et al.
- Journal Title
  
  Pharmacology 87
  
  Pages: 180-186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591818
[Journal Article] Reduction of brain infarction induced by a transient brainischemia in mdrla knockout mice2009
- Author(s)
  Michihiro Murozono
- Journal Title
  
  Neurochemical research 34
  
  Pages: 1555-1561
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591818
[Journal Article] Reduction of Brain Infarction Induced by a Transient brain Ischemia in mdr1a Knockout Mice2009
- Author(s)
  Michihiro Murozono, Shohei Matsumoto, Sinya Okada, et al.
- Journal Title
  
  Neurochem Res 34
  
  Pages: 1555-1561
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591818
[Journal Article] Isoflurane inhibits protein kinase C gamma and calcium/calmoduline dependent protein kinase II-alfa translocation to synaptic membrane in ischemic mice brains.2008
- Author(s)
  Shohei Matsumoto, Michihiro Murozono, Daisuke Nagaoka, Shuhei Matsuoka, Akiko Takeda, Hideyuki Narita, Seigo Watanabe, Atsushi Isshiki, Yasuo Watanabe
- Journal Title
  
  Neurochemical Res 33巻
  
  Pages: 2302-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591817
[Journal Article] Isoflurane inhibits protein kinase Cgamma and calcium/calmodulin dependent protein kinase ii-alpha translocation to synaptic membranes in ischemic mice brains.2008
- Author(s)
  Shohei Matsumoto Michihiro Murozono
- Journal Title
  
  Neurochemical Research 33
  
  Pages: 2302-2309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591818
[Journal Article] 新規PACAP誘導体のグリア細胞を介する脳保護効果2005
- Author(s)
  宮本麻央, 室園美智博, 松本晶平, 一色淳, 渡辺泰雄
- Journal Title
  
  蘇生 24(1)
  
  Pages: 10-16
- NAID
  10015565547
- Data Source
  KAKENHI-PROJECT-15591659
[Journal Article] Neuroprotective Effects of Novel Derivatives of Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-activating Peptide in Two Brain Ischemia Models On Mice2005
- Author(s)
  Takeda N., Murozono M., Watanabe S., Isshiki A., Watanabe Y.
- Journal Title
  
  Masui 54(3)
  
  Pages: 240-248
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591660
[Journal Article] 新規PACAP誘導体のグリア細胞を介する脳保護効果2005
- Author(s)
  宮本麻央室園美智博, 松本晶平, 一色淳, 渡辺泰雄
- Journal Title
  
  蘇生 24(1)
  
  Pages: 10-16
- NAID
  10015565547
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591659
[Journal Article] Neuroprotective effects of a novel PACAP derivative depending on presence Of glia cells2005
- Author(s)
  Miyamoto M., Murozono M,.Matsumoto S., Isshiki A., Watanabe Y.
- Journal Title
  
  Sosei 24(1)
  
  Pages: 10-16
- NAID
  10015565547
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591659
[Journal Article] Neuroprotective effects of a novel PACAP derivative depending on presence of glia cells2005
- Author(s)
  Miyamoto M., Takeda N., Murozono M., Matsumoto S., Ishhiki A., Watanabe Y.
- Journal Title
  
  Sosei 24(1)
  
  Pages: 10-16
- NAID
  10015565547
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591660
[Journal Article] Neuroprotective and neurotoxic effects of cyclosporine A on transient focal ischemia in mdrla knockout mice2004
- Author(s)
  Murozono
- Journal Title
  
  European Journal of Pharmacology 498
  
  Pages: 115-118
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591660
[Journal Article] Neuroprotective and neurotoxic effects of cyclosporine A on transient focal ischemia in mdrla knockout mice2004
- Author(s)
  Murozono M., Matsumoto E., Isshiki A., Watanabe Y.
- Journal Title
  
  European Journal of Phamacology 408
  
  Pages: 115-118
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591659
[Journal Article] Neuroprotective and neurotoxic effects of cyclosporine A on transient focal ischemia in mdrla knockout mice2004
- Author(s)
  Murozono M., Matsumoto S., Matsumoto E., Isshiki A., Watanabe Y.
- Journal Title
  
  European Journal of Pharmacology 498
  
  Pages: 115-118
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591660
[Journal Article] Neuroprotective and neurotoxic effects of cyclosporine A on transient focal ischemia in mdr1a knockout mice2004
- Author(s)
  Murozono
- Journal Title
  
  European Journal of Pharmacology 498
  
  Pages: 115-118
- Data Source
  KAKENHI-PROJECT-15591660
[Journal Article] Neuroprotective and neurotoxic effects of cyclosporine A on transient focal ischemia in mdrla knockout mice.2004
- Author(s)
  Murozono M., Matsumoto S., Matsumoto E., Isshiki A., Watanabe Y.
- Journal Title
  
  European Journal of Pharmacology 498
  
  Pages: 115-118
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591659
[Journal Article] Clinical dose of Isoflurane prevents calcium/calmodulin dependent protein kinase II but not protein kinase C translocation to synaptic membrane in the ischernic mice brain2004
- Author(s)
  Matsumoto E., Matsumoto S., Murozono M., Watanabe Y., Isshiki A.
- Journal Title
  
  Sosei 23(1)
  
  Pages: 1-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591660
[Journal Article] Neuroprotective and neurotoxic effects of cyclosporine A on transient focal ischemia in mdr1a knockout mice2004
- Author(s)
  Murozono M., Matsumoto S., Matsumoto E., Isshiki A., Watanabe Y.
- Journal Title
  
  European Journal of Pharmacology 498
  
  Pages: 115-118
- Data Source
  KAKENHI-PROJECT-15591659
[Presentation] 二次元レーザー血流計を用いたマウス-過性脳虚血モデルでの脳血流測定2010
- Author(s)
  室園美智博
- Organizer
  第57回日本麻酔科学会学術集会
- Place of Presentation
  マリンメッセ福岡(福岡)
- Year and Date
  2010-06-04
- Data Source
  KAKENHI-PROJECT-20591818
[Presentation] 二次元レーザー血流計を用いたマウス一過性脳虚血モデルでの脳血流測定2010
- Author(s)
  室園美智博, ら
- Organizer
  日本麻酔科学会第57回学術集会
- Data Source
  KAKENHI-PROJECT-20591818
[Presentation] mdr1aノックアウトマウスにおける一過性局所脳虚血でのサイトカインに関する検討2009
- Author(s)
  室園美智博, ら
- Organizer
  第24回日本shock学会総会
- Data Source
  KAKENHI-PROJECT-20591818
[Presentation] 一過性脳虚血におけるアポトーシス及びサイトカインに対する、mdr1a由来p-glycoproteinの影響2009
- Author(s)
  室園美智博, ら
- Organizer
  日本蘇生学会第28回大会
- Data Source
  KAKENHI-PROJECT-20591818
[Presentation] mdr1aノックアウトマウスによる一過性脳虚血でのアポトーシス及びサイトカインに関する検討日本麻酔科学会2009
- Author(s)
  室園美智博, ら
- Organizer
  第56回学術集会
- Data Source
  KAKENHI-PROJECT-20591818
[Presentation] Mdrlaノックアウトマウスによる一過性脳虚血でのアポトーシス及びサイトカインに関する検討2009
- Author(s)
  室園美智博
- Organizer
  日本麻酔科学会
- Place of Presentation
  神戸
- Year and Date
  2009-08-16
- Data Source
  KAKENHI-PROJECT-20591818
[Presentation] Mdrla由来P-glycoproteinの脳虚血への影響(mdrla ノックアウトマウスによる実験より)2008
- Author(s)
  室園美智博
- Organizer
  第23回日本ショック学会
- Place of Presentation
  東京
- Year and Date
  2008-05-10
- Data Source
  KAKENHI-PROJECT-20591818
[Presentation] mdr1a由来P-glycoproteinの脳虚血への影響2008
- Author(s)
  室園美智博, ら
- Organizer
  第23回日本Shock学会総会
- Data Source
  KAKENHI-PROJECT-20591818
[Presentation] サイクロスポリンAとオンダンセトロンを併用した場合の脳虚血に対する効果2007
- Author(s)
  室園美智博
- Organizer
  第9回「応用薬理」年会シンポジウム
- Place of Presentation
  東京
- Year and Date
  2007-09-10
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591725
[Presentation] Effects for cerebral ischemia on the combined medication which includes ondansetron and cyclosporin A2007
- Author(s)
  Michhiro, Murozono
- Organizer
  No. 9 "applied pharmacology" annual meeting symposium
- Place of Presentation
  Tokyo
- Year and Date
  2007-09-10
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591725
[Presentation] Co-Administration Of Cyclosporin A And Ondansetron Decreases Transient Local Cerebral Ischemic Injury In The Mouse
- Author(s)
  室園　美智博
- Organizer
  Brain　Edema
- Place of Presentation
  アメリカ合衆国　カリフォルニア
- Year and Date
  2014-09-27 – 2014-09-30
- Data Source
  KAKENHI-PROJECT-26462347

1. MATSUMOTO Shohei (30256250)

# of Collaborated Projects: 7 results

# of Collaborated Products: 11 results
2. ISSHIKI Atsushi (60074796)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
3. SEKINE Syusuke (10384976)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. WATANABE Yasuo (70183720)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
5. 岡田真也 (20297279)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 佐藤永一 (60408101)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 武田明子 (70421021)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Murozono Michihiro 室園 美智博

MUROZONO MICHIHIRO 室園 美智博

MUROZONO Mitihiro 室園 美智博

Research Projects

Research Products

Co-Researchers

Search of the effective cerebroprotection method in cerebral ischaemia which utilized brain environment derived from a transporterPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The study of a new target for the effects of volatile anesthetics by immunoblotting.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The elucidation of the intracerebral transporter control to lead the new cerebroprotection methodPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A research of new cerebroprotection method discovered from cross talk among intracerebral compartmentsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The novel analyzing assay for neuroprotection of the inhalation anesthetics by immuno-precipitation and the protein kinases related cerebral ischemia.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Neuroprotective effects of inhalation anesthetics based on the analysis of the signal transduction related to ubiquitous protein kinases.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Neuroimmunologic research of endogenous and exogenous protection on brain, taking account of the meaning of the BBB's existencePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation into the cross-talk of cell adhesion molecule in the brain on the mechanism, of neuronal protectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Neuroprotective effect of cyosporinA. (Study for mitochordrial permeability transition pore and cytochromeC)

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Effects of different types of aneathetic arents on cellular PKC γ dynamics in mouse brain2011

Author(s)

Journal Title

Data Source

[Journal Article] Effects of Differential Types of Anesthetic Agents on Cellular Protein Kinase C-γ Dynamics in Mouse Brain2011

Author(s)

Journal Title

Data Source

[Journal Article] Reduction of brain infarction induced by a transient brainischemia in mdrla knockout mice2009

Author(s)

Journal Title

Data Source

[Journal Article] Reduction of Brain Infarction Induced by a Transient brain Ischemia in mdr1a Knockout Mice2009

Author(s)

Journal Title

Data Source

[Journal Article] Isoflurane inhibits protein kinase C gamma and calcium/calmoduline dependent protein kinase II-alfa translocation to synaptic membrane in ischemic mice brains.2008

Author(s)

Journal Title

Data Source

Murozono Michihiro 室園美智博

MUROZONO MICHIHIRO 室園美智博

MUROZONO Mitihiro 室園美智博