IKARASHI Yoshinori 五十嵐美徳

Researcher Number	70280782
Other IDs
Affiliation (Current)	2022: 国立研究開発法人国立がん研究センター, 研究所, 主任研究員
Affiliation (based on the past Project Information) *help	2015 – 2016: 国立研究開発法人国立がん研究センター, 研究所, 外来研究員 2010 – 2014: 独立行政法人国立がん研究センター, 研究所, 主任研究員 2002 – 2003: 国立がんセンター, 研究所・薬効試験部, 研究員 2002 – 2003: 国立がんセンター研究所, 薬効試験部, 研究員
Review Section/Research Field	Principal Investigator Experimental pathology / Immunology Except Principal Investigator Immunology
Keywords	Principal Investigator 同種造血幹細胞移植 / 移植片対宿主病 / GFP / NKT細胞 / キラー抑制レセプター / キラー活性化レセプター / CD1d / CD94 / NKG21) / KIR … More Except Principal Investigator G-CSF / ヒトVα24陽性NKT細胞 / 自己血清 / IFN-γ / IL-4 / CD1d非拘束性細胞障害 / ヒトNKT細胞 / 対外増殖法 / 自己血漿 / CD1d非拘束性 / CTL / NK細胞 / NKT細胞 / G-CSF投与 / Vα24^+NKT細胞 / ヒト血清・血漿 / 抗腫瘍活性 / V_α24^+NKT / α-GalCer / IL-2 Less

Functional in vivo cellular imaging of graft-versus-host disease in allogeneic hematopoietic stem cell transplantation in micePrincipal Investigator
- Principal Investigator
  
  Ikarashi Yoshinori
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  National Cancer Center Japan
Non-invasive in vivo fluorescence imaging in allogeneic hematopoi etic stem cell transplantation mouse modelPrincipal Investigator
- Principal Investigator
  
  IKARASHI Yoshinori
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  National Cancer Center Japan
キラー抑制レセプターによるNKT細胞の活性化の制御に関する研究Principal Investigator
- Principal Investigator
  
  五十嵐美徳
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
Analysis of human NKT cells and the development of exvivo expansion methods
- Principal Investigator
  
  WAKASUGI Hiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  National Cancer Center Research Institute

All 2013 2012 2011 2010 2004 2003 2002

All Journal Article Presentation Book

[Book] Role Of Natural Killer T Cells In Anti-Tumor Immune Response.2004
- Author(s)
  Y.Ikarashi, et al.
- Publisher
  Princes Takamatsu Cancer Research Fund
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570291
[Journal Article] Real-time in vivo cellular imaging of graft-versus-host disease and its reaction to immunomodulatory reagents2012
- Author(s)
  Takahiro Yamazaki, Yoshinori Ikarashi et al.
- Journal Title
  
  Immunology Letters
  
  Volume: 144巻 Pages: 33-40
- DOI
  10.1016/j.imlet.2012.03.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590372, KAKENHI-PROJECT-23590384
[Journal Article] In vivo delivery of interferon-a gene enhances tumor immunity and suppresses immunotolerance in reconstituted lymphopenic hosts2012
- Author(s)
  Narumi, K., Udagawa, T., Kondoh, A., Kobayashi, A., Hara, H., Ikarashi, Y., Ohnami, S., Takeshita, F., Ochiya, T., Okada, T., Yamagishi, M., Yoshida, T., Aoki, K.
- Journal Title
  
  Gene Terapy
  
  Volume: 287 Pages: 1397-1405
- DOI
  10.1038/gt.2011.73
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008, KAKENHI-PROJECT-22590372, KAKENHI-PROJECT-23590384
[Journal Article] The mouse natural killer T cell-associated antigen recognaized by U5A2-13 monoclonal antibody is intercellular adhesion molecule-12004
- Author(s)
  Shimizu, A., Sasaki, H., Aoyagi., Yoshida, M., Kato, K., Heike, Y., Ikarashi, Y., Shirakawa, K., Takaue, Y., Miyajima, A., Terada, M., Nagai, H., Wakasugi, H.
- Journal Title
  
  Immunology Letters 92
  
  Pages: 227-235
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570291
[Journal Article] Role Of Natural Killer T Cells In Anti-Tumor Immune Response.2004
- Author(s)
  Yoshinori Ikarashi, Yuji Heike, Atsushi Shimizu, Osamu Imataki, Sachiyo Kanai, Mitsuzi Yoshida, Akira liduka, Takayuki Morikawa, Yoichi Takauel, Hiro Wakasugi.
- Journal Title
  
  Extended Abstracts for the 34nd International Symposium of the Princess Takamatsu Cancer Research Fund, Tokyo, 2004.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570291
[Journal Article] CD4^+ CD25^+ T cells responding to serologically defined autoantigens suppress antitumor immune responses.2003
- Author(s)
  Hiroyoshi Nishikawa, Takuma Kato, Koji Tanida, Atsunori Hiasa, Isao Tawara, Hiroaki Ikeda, Yoshinori Ikarashi, Hiro Wakasugi, Mitchell Kronenberg, Toshinori Nakayama, Masaru Taniguchi, Kagemasa Kuribayashi, Lloyd J.Old, Hiroshi Shiku.
- Journal Title
  
  Proc Natl Acad Sci USA 100
  
  Pages: 10902-10906
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570291
[Journal Article] Increased expansion of V_24^+T cells derived from G-CSF mobilized peripheral blood stem cells as compared to peripheral blood mononuclear cells following_-galactosylceramide stimulation.2003
- Author(s)
  Rumiko Asada-Mikami, Yuji Heike, Yukie Harada, Sachiyo Kanai, Yoshinori Ikarashi, Kazunori Kato, Kazuo Shirakawa, Yoichi Takaue, Tatsuo Abe, Hiro Wakasugi.
- Journal Title
  
  Cnacer Science 94
  
  Pages: 383-388
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570291
[Journal Article] U5A2-13, an antigen originally found on mouse NK-like T Cells, is an early inducible cell surface antigen during lymphoid activation.2003
- Author(s)
  Kazunori Kato, Yoshinori Ikarashi, Toshiaki Sugahara, Atsushi Yasumoto, David Sancho, Mitsuzi Yoshida, Yoichi Takaue, Yoshiro Kobayashi, Francisco Sanchez-Madrid, Hiro Wakasugi.
- Journal Title
  
  Cellular Immunology 221
  
  Pages: 27-36
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570291
[Journal Article] U1B3.3 monoclonal antibody recognizes a precursor of NK1.1+ cytotoxic T cells generated by interleukin-22002
- Author(s)
  Y.Ikarashi, et al.
- Journal Title
  
  Proceedings of the Japan Academy 78
  
  Pages: 91-95
- NAID
  130000907847
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570291
[Journal Article] U1B3.3 monoclonal antibody recognizes a precursor of NK1.1^+ cytotoxic T cells generated by interleukin-2.2002
- Author(s)
  Ikarashi Y, Kato K, Yoshida M, Wakasugi H.
- Journal Title
  
  Proc.Japan Acad. 78
  
  Pages: 91-95
- NAID
  130000907847
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570291
[Presentation] Inhibition of graft-versus-host disease by NKT cell-ligand is attributed to suppression of donor T cell proliferation2013
- Author(s)
  Takuya Matsuyama, Toshio Imai, Yuji Heike, Kazunori Aoki, Kazunori Kato, Sung-won Kim, Hitoshi Nakagama Yoshinori Ikarashi
- Organizer
  日本癌学会学術集会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-25460509
[Presentation] NKT cell-ligand inhibits donor engraftment after allogeneic hematopoietic stem cell transplantation2012
- Author(s)
  Yoshinori Ikarashi
- Organizer
  日本癌学会
- Place of Presentation
  札幌市
- Year and Date
  2012-09-20
- Data Source
  KAKENHI-PROJECT-22590372
[Presentation] The effect of NKT cell ligand for donor cell engraftment by in vivo fluo rescence imaging in Allogeneic HSCT2011
- Author(s)
  Ikarashi Y, Heike Y, Kim SW, Nakagama H, Aoki K
- Organizer
  日本癌学会
- Place of Presentation
  名古屋市
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-22590372
[Presentation] The effect of NKT cell ligand for donor cell engraftment by In vzvo fluorescence imaging in Allogeneic HSCT2011
- Author(s)
  Yoshinori Ikarashi
- Organizer
  日本癌学会
- Place of Presentation
  名古屋市
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-22590372
[Presentation] Inhibition of regulatory T cell enhance antitumor immunity induced by intratumoral IFN-α gene transfer2011
- Author(s)
  Aida K, Udagawa T, Narumi K, Suzuki K, Goto N, Ikarashi Y, Ohnami S, Yoshida T, Aoki K
- Organizer
  日本癌学会
- Place of Presentation
  名古屋市
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-22590372
[Presentation] Autologous hematopoietic stem cell transplantation suppresses immunotolerant environment in tumors2011
- Author(s)
  Udagawa T, Narumi K, Aida K, Suzuki K, Goto N, Ikarashi Y, Ohnami S, Yoshida T, Aoki K
- Organizer
  日本癌学会
- Place of Presentation
  名古屋市
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-22590372
[Presentation] Differential chimerism of Langerhans cells, dermal dendritic cells and dendritic epidermal T cells after nonmyeloablativeallogeneic hematopoietic stem cell transplantation2010
- Author(s)
  Yoshinori Ikarashi
- Organizer
  International Symposium on Dendritic Cells in Fundamental and Clinical Immunology
- Place of Presentation
  ルガーノスイス
- Year and Date
  2010-09-29
- Data Source
  KAKENHI-PROJECT-22590372
[Presentation] Screening of immunomodulating drugs for graft-versus-host disease by in vivo fluorescence imaging2010
- Author(s)
  Yoshinori Ikarashi
- Organizer
  ISCT Asia-Pacific Regional meeting
- Place of Presentation
  宮崎市
- Year and Date
  2010-10-18
- Data Source
  KAKENHI-PROJECT-22590372
[Presentation] Differential chimerism of Langerhans cells, dermal dendritic cells and dendritic epidermal T cells after nonmyeloablative allogeneic hematopoietic stem cell transplantation.2010
- Author(s)
  Yoshinori Ikarashi
- Organizer
  International Symposium on Dendritic Cells in Fundamental and Clinical Immunology
- Place of Presentation
  Lugano, Switzerland
- Year and Date
  2010-10-18
- Data Source
  KAKENHI-PROJECT-22590372
[Presentation] Noninvasive monitoring of donor cell infiltration in mouse graft-versus-host disease using in vivo fluorescence imaging2010
- Author(s)
  Yoshinori Ikarashi
- Organizer
  日本癌学会
- Place of Presentation
  大阪市
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22590372

1. WAKASUGI Hiro (10112632)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
2. 青木一教

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 竹下文隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

IKARASHI Yoshinori 五十嵐 美徳

Research Projects

Research Products

Co-Researchers

Functional in vivo cellular imaging of graft-versus-host disease in allogeneic hematopoietic stem cell transplantation in micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Non-invasive in vivo fluorescence imaging in allogeneic hematopoi etic stem cell transplantation mouse modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

キラー抑制レセプターによるNKT細胞の活性化の制御に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of human NKT cells and the development of exvivo expansion methods

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Role Of Natural Killer T Cells In Anti-Tumor Immune Response.2004

Author(s)

Publisher

Description

Data Source

[Journal Article] Real-time in vivo cellular imaging of graft-versus-host disease and its reaction to immunomodulatory reagents2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vivo delivery of interferon-a gene enhances tumor immunity and suppresses immunotolerance in reconstituted lymphopenic hosts2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The mouse natural killer T cell-associated antigen recognaized by U5A2-13 monoclonal antibody is intercellular adhesion molecule-12004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Role Of Natural Killer T Cells In Anti-Tumor Immune Response.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] CD4^+ CD25^+ T cells responding to serologically defined autoantigens suppress antitumor immune responses.2003

Author(s)

Journal Title

Description

Data Source

[Journal Article] Increased expansion of V_24^+T cells derived from G-CSF mobilized peripheral blood stem cells as compared to peripheral blood mononuclear cells following_-galactosylceramide stimulation.2003

Author(s)

Journal Title

Description

Data Source

[Journal Article] U5A2-13, an antigen originally found on mouse NK-like T Cells, is an early inducible cell surface antigen during lymphoid activation.2003

Author(s)

Journal Title

Description

Data Source

[Journal Article] U1B3.3 monoclonal antibody recognizes a precursor of NK1.1+ cytotoxic T cells generated by interleukin-22002

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] U1B3.3 monoclonal antibody recognizes a precursor of NK1.1^+ cytotoxic T cells generated by interleukin-2.2002

Author(s)

Journal Title

NAID

Description

Data Source

IKARASHI Yoshinori 五十嵐美徳