Kinoh Hiroaki 喜納宏昭

… Alternative Names

Researcher Number	70283067
Other IDs
Affiliation (Current)	2022: 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 主幹研究員
Affiliation (based on the past Project Information) *help	2021: 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 主幹研究員 2017 – 2019: 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 主幹研究員
Review Section/Research Field	Principal Investigator Tumor therapeutics / Basic Section 50010:Tumor biology-related
Keywords	Principal Investigator ナノ治療薬 / 膵臓がん / がん幹細胞 / 難治癌 / K252a ミセル / スタウロスポリン / エピルビシン / ミセル / MDR-1 / 癌幹細胞阻害剤 … More

Development of nano-therapeutic agents to overcome immune checkpoint inhibitor resistance due to tumor stroma of intractable cancerPrincipal Investigator
- Principal Investigator
  
  喜納宏昭
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine
Creation of novel nanomedicine targeting drug-resistant cancer stem cells in recurrent refractory cancerPrincipal Investigator
- Principal Investigator
  
  Kinoh Hiroaki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine

All 2020 2019 2018 2017

All Journal Article Presentation Patent

[Journal Article] Nanomedicines blocking adaptive signals in cancer cells overcome tumor TKI resistance2020
- Author(s)
  H. Kinoh, H. Shibasaki, X. Liu, T. Yamasoba, H. Cabral, K. Kataoka
- Journal Title
  
  J. Control. Release
  
  Volume: 321 Pages: 132-144
- DOI
  10.1016/j.jconrel.2020.02.008
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03179, KAKENHI-PROJECT-17K07234, KAKENHI-PROJECT-18K19901
[Journal Article] Single-Stranded DNA-Packaged Polyplex Micelle as Adeno-Associated-Virus-Inspired Compact Vector to Systemically Target Stroma-Rich Pancreatic Cancer2019
- Author(s)
  T. A. Tockary, W. Foo, A. Dirisala, Q. Chen, S. Uchida, S. Osawa, Y. Mochida, X. Liu, H. Kinoh, H. Cabral, K. Osada, K. Kataoka
- Journal Title
  
  ACS Nano
  
  Volume: 13 Pages: 12732-12742
- DOI
  10.1021/acsnano.9b04676
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K20086, KAKENHI-PROJECT-18K18393, KAKENHI-PROJECT-17KK0102, KAKENHI-PROJECT-16H03178, KAKENHI-PROJECT-16H03179, KAKENHI-PROJECT-18H03529, KAKENHI-PROJECT-17K07234, KAKENHI-PROJECT-18K19901
[Journal Article] Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells2019
- Author(s)
  Y. Yi, H. J. Kim, M. Zheng, P. Mi, M. Naito, B. S. Kim, H. S. Min, K. Hayashi, F. Perche, K. Toh, X. Liu, Y. Mochida, H. Kinoh, H. Cabral, K. Miyata, K. Kataoka
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 295 Pages: 268-277
- DOI
  10.1016/j.jconrel.2019.01.006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07234, KAKENHI-PROJECT-18K18378, KAKENHI-PROJECT-17H02098, KAKENHI-PROJECT-18H04170, KAKENHI-PROJECT-20K20386, KAKENHI-PROJECT-18K18391
[Journal Article] Therapeutic polymersome nanoreactors with tumor-specific activable cascade reactions for cooperative cancer therapy2019
- Author(s)
  W. Ke, J. Li, F. Mohammed, Y. Wang, K. Tou, X. Liu, P. Wen, H. Kinoh, Y. Anraku, H. Chen, K. Kataoka, Z. Ge,
- Journal Title
  
  ACS Nano
  
  Volume: 13 Pages: 2357-2369
- DOI
  10.1021/acsnano.8b09082
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07234, KAKENHI-PROJECT-17H04742, KAKENHI-PROJECT-17K20094
[Journal Article] In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancer.2019
- Author(s)
  Watanabe Sumiyo、Hayashi Kotaro、Toh Kazuko、Kim Hyun Jin、Liu Xueying、Chaya Hiroyuki、Fukushima Shigeto、Katsushima Keisuke、Kondo Yutaka、Uchida Satoshi、Ogura Satomi、Nomoto Takahiro、et al.
- Journal Title
  
  Nat. Commun.
  
  Volume: 10 Pages: 1-13
- DOI
  10.1038/s41467-019-09856-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18383, KAKENHI-PROJECT-17KT0048, KAKENHI-PROJECT-19K12799, KAKENHI-PROJECT-17K20086, KAKENHI-PROJECT-18K18391, KAKENHI-PROJECT-17KK0102, KAKENHI-PROJECT-18H04163, KAKENHI-PROJECT-16H03178, KAKENHI-PROJECT-17H03582, KAKENHI-PROJECT-18H02797, KAKENHI-PROJECT-18H03529, KAKENHI-PROJECT-17H04743, KAKENHI-PROJECT-17K07234
[Journal Article] Effective treatment of drug resistant recurrent breast tumors harboring cancer stem-like cells by staurosporine/epirubicin co-loaded polymeric micelles2017
- Author(s)
  J. Zhang, H. Kinoh, L. Hespel, X. Liu, S. Quader, J. Martin, T. Chida, H. Cabral, K. Kataoka,
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 264 Pages: 127-135
- DOI
  10.1016/j.jconrel.2017.08.025
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07234, KAKENHI-PROJECT-16H03179, KAKENHI-PROJECT-16F16731, KAKENHI-PROJECT-16K12904
[Journal Article] cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells.2017
- Author(s)
  Miyano Kazuki、Cabral Horacio、Miura Yutaka、Matsumoto Yu、Mochida Yuki、Kinoh Hiroaki、Iwata Caname、Nagano Osamu、Saya Hideyuki、Nishiyama Nobuhiro、Kataoka Kazunori、Yamasoba Tatsuya
- Journal Title
  
  J. Control. Release
  
  Volume: 261 Pages: 275-286
- DOI
  10.1016/j.jconrel.2017.06.021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KT0048, KAKENHI-PROJECT-16K11226, KAKENHI-PROJECT-17K07234, KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-15H04635, KAKENHI-PROJECT-16H03179, KAKENHI-PROJECT-16H05422, KAKENHI-PROJECT-17H06641, KAKENHI-PROJECT-16F16058, KAKENHI-PROJECT-16F16407, KAKENHI-PROJECT-16K15104
[Patent] 脳腫瘍治療薬2019
- Inventor(s)
  喜納宏昭、片岡一則
- Industrial Property Rights Holder
  公益財団法人　川崎市産業振興財団
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-17K07234
[Patent] 医薬組成物2018
- Inventor(s)
  カダール・サビーナ,カブラル・オラシオ, 喜納宏昭, 片岡一則
- Industrial Property Rights Holder
  カダール・サビーナ,カブラル・オラシオ, 喜納宏昭, 片岡一則
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-030208
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17K07234
[Patent] ポリマー、ポリマーの製造方法、薬物複合体及びミセル2018
- Inventor(s)
  カダール・サビーナ,カブラル・オラシオ, 喜納宏昭, 片岡一則
- Industrial Property Rights Holder
  カダール・サビーナ,カブラル・オラシオ, 喜納宏昭, 片岡一則
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-030209
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17K07234
[Patent] 薬物複合体、ミセル、及び医薬組成物2018
- Inventor(s)
  カダール・サビーナ,カブラル・オラシオ, 喜納宏昭, 片岡一則
- Industrial Property Rights Holder
  カダール・サビーナ,カブラル・オラシオ, 喜納宏昭, 片岡一則
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-030200
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17K07234
[Patent] ポリマー、ポリマーの製造方法、及び薬物複合体2017
- Inventor(s)
  カダール・サビーナ,カブラル・オラシオ, 喜納宏昭, 片岡一則
- Industrial Property Rights Holder
  カダール・サビーナ,カブラル・オラシオ, 喜納宏昭, 片岡一則
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Overseas
- Data Source
  KAKENHI-PROJECT-17K07234
[Presentation] Targeting Intractable Cancers Using Extracellular pH sensitive NanoMedicine2019
- Author(s)
  S. Quader, X. Liu, H. Kinoh, K. Kataoka
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07234
[Presentation] (+)-JQ-1誘導体を内包したpH反応性新規ナノ粒子のc-Myc高発現腫瘍に対する抗腫瘍効果2019
- Author(s)
  柴崎仁志、喜納宏昭、S. Quader、持田祐希、L. Xueying、C. Horacio、松本有、片岡一則、山岨達也
- Organizer
  第120回日本耳鼻咽喉科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-17K07234
[Presentation] Novel pH-sensitive Nanomedicine Conjugating (+)-JQ-1 Homolog Inhibits the Growth of the Head and Neck Cancer which Overexpress c-Myc2019
- Author(s)
  Hiroaki Kinoh
- Organizer
  12th Annual Symposium on Nanotechnology,
- Invited
- Data Source
  KAKENHI-PROJECT-17K07234
[Presentation] Nanomedicine Loading Staurosporine homolog (K252a-hydrozyde) overcomes osimertinib resistance in non small lung cancer2019
- Author(s)
  喜納宏昭、柴崎仁志、S. Quader、X. Liu、H. Cabral、片岡一則
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07234
[Presentation] 薬剤耐性および再発/転移する難治癌に対して著効するナノDDS製剤の開発,2018
- Author(s)
  喜納宏昭
- Organizer
  第27回日本がん転移学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K07234
[Presentation] pH応答性抗癌剤ナノミセルは、 PTEN/VHL発現欠失スニチニブ耐性腎癌に対しても有効である。2017
- Author(s)
  喜納宏昭、H. Cabral、北村貴美子、片岡一則
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07234
[Presentation] pH応答性スタウロスポリン内包エピルビシンミセルは、スニチニブ耐性獲得腎癌に対しても高い抗腫瘍効果を示す2017
- Author(s)
  喜納宏昭、H. Cabral、北村貴美子、片岡一則
- Organizer
  第33回DDS学会学術大会
- Data Source
  KAKENHI-PROJECT-17K07234
[Presentation] pH応答性ナノミセルは、 PTEN/VHL発現欠失スニチニブ耐性腎癌に対して有効であり、転移に対しても著効を示す2017
- Author(s)
  喜納宏昭、片岡一則
- Organizer
  第21回日本がん分子標的学会
- Data Source
  KAKENHI-PROJECT-17K07234

1. 劉学瑩 (30777470)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. Cabral Horacio (10533911)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. Quader Sabina (90749699)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. OSADA Kensuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. MATSUMOTO Yu

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. Miyano Kazuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. Horacio Cabral

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. MIURA Yutaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. ANRAKU Yasutaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. KANO Mitsunobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. MARTIN JOHN

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 内田智士

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. ディリサラアンジャネユル

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 持田祐希

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 佐谷秀行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 青木伊知男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 西山伸宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. Kim HyunJin

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 宮田完二郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 片岡一則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 林光太朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
22. 野本貴大

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 武元宏泰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 近藤豊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kinoh Hiroaki 喜納 宏昭

喜納 宏昭 キノウ ヒロアキ

Research Projects

Research Products

Co-Researchers

Development of nano-therapeutic agents to overcome immune checkpoint inhibitor resistance due to tumor stroma of intractable cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Creation of novel nanomedicine targeting drug-resistant cancer stem cells in recurrent refractory cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Nanomedicines blocking adaptive signals in cancer cells overcome tumor TKI resistance2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Single-Stranded DNA-Packaged Polyplex Micelle as Adeno-Associated-Virus-Inspired Compact Vector to Systemically Target Stroma-Rich Pancreatic Cancer2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Therapeutic polymersome nanoreactors with tumor-specific activable cascade reactions for cooperative cancer therapy2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancer.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effective treatment of drug resistant recurrent breast tumors harboring cancer stem-like cells by staurosporine/epirubicin co-loaded polymeric micelles2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells.2017

Author(s)

Journal Title

DOI

Data Source

[Patent] 脳腫瘍治療薬2019

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] 医薬組成物2018

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Patent] ポリマー、ポリマーの製造方法、薬物複合体及びミセル2018

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Patent] 薬物複合体、ミセル、及び医薬組成物2018

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Patent] ポリマー、ポリマーの製造方法、及び薬物複合体2017

Kinoh Hiroaki 喜納宏昭

喜納宏昭キノウヒロアキ