Sakai Akira 坂井晃

… Alternative Names

SAKAI Akira 坂井晃

坂井昇サカイノボル

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Researcher Number	70284221
Other IDs
External Links
Affiliation (Current)	2025: 福島県立医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2011 – 2023: 福島県立医科大学, 医学部, 教授 2007: Hiroshima University, Hospital, Assistant Professor 2004 – 2006: 広島大学, 病院・講師 2003: Hiroshima University, Medical and Dental Hospital, Assistant Professor, 医学部・歯学部附属病院, 講師 2002: 広島大学, 医学部附属病院, 講師
Review Section/Research Field	Principal Investigator Laboratory medicine / Basic Section 54010:Hematology and medical oncology-related / Hematology / Hematology Except Principal Investigator Radiation science / Basic Section 52040:Radiological sciences-related / Basic Section 63020:Radiation influence-related / Orthopaedic surgery
Keywords	Principal Investigator Bim / Lyn / Siva / 多発性骨髄腫 / 生物学的線量評価 / CT検査 / 医療被ばく / 転座型染色体 / 二動原体染色体 / 造血前駆細胞 … More / 染色体転座 / 骨髄前駆細胞 / 骨髄先駆細胞 / 形質転換 / 再プログラミング / iPS細胞 / 成熟Bリンパ球 / 染色体 / 染色体異常 / 医療被曝 / 低線量被曝 / molecular response / Src-kinase / cell line / drug-resistance / imatinib / CML / 分子遺伝学的効果 / Src kinase / 細胞株 / 耐性 / イマチニブ / 慢性骨髄性白血病 / multiple myeloma / apoptosis / CD27-CD70 interaction / アポトーシス / CD27-CD70結合 / CD70 / CD27 / FISH法 / Giemsa染色 / 低線量被ばく … More Except Principal Investigator 染色体転座 / 二動原体染色体 / 放射線感受性 / 染色体異常 / CRISPR/Cas9 / 責任遺伝子 / 電離放射線 / CRISPR-Cas9 / 放射線発がん / ゲノム編集 / クロモトリプシス / 微小核 / Ewing's sarcoma / Chondrosarcoma / Osteosarcoma / Bisphosphonate / 腫瘍細胞浸潤抑制 / 細胞周期 / アポトーシス / ビスフォスフォネート / 骨肉腫 / 被ばく医療 / 動脈硬化症 / 糖尿病 / 分裂頻度 / 抗凝固剤 / 血液搬送 / バイオドシメトリー / 個人感受性 / 線量評価 / 放射線 / CPI / PCC法 / 生活習慣病 / 放射線個人感受性 / メタボリックシンドローム / 緊急被ばく医療 / 細胞遺伝学的線量評価 / 続発性骨粗鬆症 / 多列検出器CT / 骨梁構造解析 / 骨粗鬆症 / 海綿骨骨梁構造解析 / 骨粗鬆症性脊椎骨折 Less

標的ゲノム編集/系統的ノックダウンによる染色体転座頻度を増加させる因子の探索
- Principal Investigator
  
  津山尚宏
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Hiroshima University
  Fukushima Medical University
How does aberrant B lymphocyte produce a origin of multiple myeloma cells?Principal Investigator
- Principal Investigator
  
  Sakai Akira
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Fukushima Medical University
Analysis of micronucleus/chromotrypsis formation process by inducible Dic.
- Principal Investigator
  
  Tsuyama Naohiro
- Project Period (FY)
  2018 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Hiroshima University
  Fukushima Medical University
Analysis of influence of medical radiation exposure on chromosome by CT examination and biological dose evaluationPrincipal Investigator
- Principal Investigator
  
  SAKAI AKIRA
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Fukushima Medical University
Application of cell cycle progression index to radiosensitivity evaluation and analysis of background factors on chromosome aberration
- Principal Investigator
  
  Miura Tomisato
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Hirosaki University
Establishment of biological dose assessment method using the chromosome analysis in low-dose radiation exposure.Principal Investigator
- Principal Investigator
  
  Sakai Akira
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Fukushima Medical University
Vertebral fracture risk in osteoporosis assessed by a multidetector CT-based trabecular structure analysis
- Principal Investigator
  
  TAKASU Miyuki
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Hiroshima University
Mechanisms of imatinib-resistance in clinical patients and imatinib-resistant cell line showing over-expression of Lyn in chronic myelogenous leukemia (CML)Principal Investigator
- Principal Investigator
  
  SAKAI Akira, 田中英夫
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Hiroshima University
Inhibitory effects of a new bisphosphonate, minodronate, on proliferation and invasion of a variety of malignant bone tumor cells
- Principal Investigator
  
  SHIMOSE Shouji
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  HIROSHIMA UNIVERSITY
The significant role for the loss of CD27-expression in myelomagenesisPrincipal Investigator
- Principal Investigator
  
  SAKAI Akira
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  HIROSHIMA UNIVERSITY

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011

All Journal Article Presentation Book

[Book] 多発性骨髄腫の進展と遺伝子不安定性.2018
- Author(s)
  坂井　晃
- Total Pages
  7
- Publisher
  日本臨床. 特集
- Data Source
  KAKENHI-PROJECT-16K08970
[Journal Article] No increase in translocated chromosomal aberrations, an indicator of ionizing radiation exposure, in childhood thyroid cancer in Fukushima Prefecture.2023
- Author(s)
  Sakai A, Tsuyama N, Ohira T, Sugai-Takahashi M, Ohba T, Azami Y, Matsumoto Y, Iwadate Manabu, Suzuki S, Sato M, Hosoya M, Ishikawa T, Suzuki S.
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 14254-14254
- DOI
  10.1038/s41598-023-41501-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07681, KAKENHI-PROJECT-18K11647
[Journal Article] Chromosomal translocation t(11;14) and p53 deletion induced by the CRISPR/Cas9 system in normal B cell-derived iPS cells2021
- Author(s)
  Yusuke Azami, Naohiro Tsuyama, Yu Abe, Misaki Sugai-Takahashi, Ken-Ichi Kudo, Akinobu Ota, Karnan Sivasundaram , Moe Muramatsu, Tomonari Shigemura, Megumi Sasatani, Yuko Hashimoto, Shigehira Saji, Kenji Kamiya, Ichiro Hanamura, Takayuki Ikezoe, Masafumi Onodera, Akira Sakai.
- Journal Title
  
  Sci Rep
  
  Volume: 11 Issue: 1 Pages: 5216-5216
- DOI
  10.1038/s41598-021-84628-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08738, KAKENHI-PROJECT-20K20310, KAKENHI-PROJECT-20K21846, KAKENHI-PROJECT-19K17275, KAKENHI-PROJECT-17H00785, KAKENHI-PROJECT-18H02844, KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-18K11647, KAKENHI-PROJECT-21K07681, KAKENHI-PROJECT-21K08426, KAKENHI-PROJECT-19K09292
[Journal Article] Induction of t(11;14) IgH enhancer/promoter-Cyclin D1 gene translocation using CRISPR/Cas9.2019
- Author(s)
  Tsuyama N, Abe Y, Yanagi A, Yanai Y, Sugai M, Katafuchi A, Kawamura F, Kamiya K, Sakai A.
- Journal Title
  
  Oncology Letters. 18 : 275-282, 2019.
  
  Volume: 18 Pages: 275-282
- DOI
  10.3892/ol.2019.10303
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11647, KAKENHI-PROJECT-19K17275, KAKENHI-PROJECT-17H00785, KAKENHI-PROJECT-20K20310
[Journal Article] Dose-response curves for analyzing of dicentric chromosomes and chromosome translocation following doses of 1,000 mGy or less based on irradiated peripheral blood samples from 5 healthy individuals.2018
- Author(s)
  Abe Y, Yoshida MA, Fujioka K, Kurosu Y, Ujiie R, Yanagi A, Tsuyama N, Miura T, Inaba T, Kamiya K, Sakai A
- Journal Title
  
  Journal of Radiation Research
  
  Volume: 59 Issue: 1 Pages: 35-42
- DOI
  10.1093/jrr/rrx052
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19804, KAKENHI-PROJECT-15H04857, KAKENHI-PROJECT-18K11647, KAKENHI-PROJECT-18H02838, KAKENHI-PROJECT-15K00543, KAKENHI-PROJECT-16K08970, KAKENHI-PROJECT-20K20310
[Journal Article] Analysis of chromosome translocation frequency after a single CT scan in adults2016
- Author(s)
  Yu Abe, Tomisato Miura, Mitsuaki A. Yoshida, et al.
- Journal Title
  
  Journal of Radiation Research,
  
  Volume: 57 Issue: 3 Pages: 1-7
- DOI
  10.1093/jrr/rrv090
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19804, KAKENHI-PROJECT-24619004, KAKENHI-PROJECT-25460694, KAKENHI-PROJECT-26293270, KAKENHI-PROJECT-15K00543, KAKENHI-PROJECT-16K09854, KAKENHI-PROJECT-16K10687
[Journal Article] Increase in dicentric chromosome formation after a single CT scan in adults.2015
- Author(s)
  Abe Y, Miura T, Yoshida MA, Ujiie R, Kurosu Y, Kato N, Katafuchi A, Tsuyama N, Ohba T, Inamasu T, Shishido F, Noji H, Ogawa K, Yokouchi H, Kanazawa K, Ishida T, Muto S, Ohsugi J, Suzuki H, Ishikawa T, Kamiya K, Sakai A.
- Journal Title
  
  Scinetific Reports
  
  Volume: 9 Issue: 1 Pages: 13882-13882
- DOI
  10.1038/srep13882
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00543, KAKENHI-PROJECT-15K19804, KAKENHI-PROJECT-24619004, KAKENHI-PROJECT-25460694, KAKENHI-PROJECT-25461431, KAKENHI-PROJECT-25461869, KAKENHI-PROJECT-15K12207, KAKENHI-PROJECT-25281020
[Journal Article] Vertebral fracture risk of multiple myeloma assessed by a CT-based finite element- and trabecular structure analysis.2014
- Author(s)
  Takasu M
- Journal Title
  
  Clinical Lymphoma Myeloma and Leukemia
  
  Volume: 14 Issue: 1 Pages: 12-13
- DOI
  10.1371/journal.pone.0085931
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591768
[Journal Article] Iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) imaging of multiple myeloma: initial clinical efficiency results.2012
- Author(s)
  Takasu M, Tani C, Sakoda Y, Ishikawa M, Tanitame K, Date S, Akiyama Y, Sakai A, Asaoku H, Kajima T, Awai K.
- Journal Title
  
  Eur Radiol.
  
  Volume: 22 Issue: 4 Pages: 1114-21
- DOI
  10.1007/s00234-013-1137-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591768
[Journal Article] Multiple Myeloma: Microstructural Analysis of Lumbar Trabecular Bones in Patients without Visible Bone Lesions--Preliminary Results2011
- Author(s)
  Takasu M, Tani C, Ishikawa M, Date S, Horiguchi J, Kiguchi M, Tamura A, Sakai A, Asaoku H, Nango N, Awai K
- Journal Title
  
  Radiology
  
  Volume: 260 Pages: 472-479
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591768
[Presentation] Analysis of differential gene expression in t(11;14) carrying iPS cells induced by genome editing and Cre-loxP2023
- Author(s)
  Naohiro Tsuyama, Yu Abe, Misaki Sugai Takahashi, Kenji Kamiya, Akira Sakai
- Organizer
  The 7th International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07681
[Presentation] Analysis of differential gene expression in t(11;14) carrying iPS cells induced by genome editing and Cre-loxP.2023
- Author(s)
  Naohiro Tsuyama, Yu Abe, Misaki Sugai Takahashi, Kenji Kamiya, Akira Sakai
- Organizer
  The 7th International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11647
[Presentation] Attempts to induce t(11;14) during the redifferentiation of iPS cells into B cells.2022
- Author(s)
  Misaki Takahashi, Naohiro Tsuyama, Ken-ichi Kudo, Yusuke Azami, Miwa Fukami, Takayuki Ikezoe, Masafumi Onodera, Akira Sakai.
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08738
[Presentation] Analysis of differential gene expression in t(11;14) carrying iPS cells induced by genome editing.2022
- Author(s)
  Naohiro TSUYAMA, Kenichi KUDO, Misaki SUGAI-TAKAHASHI, Yusuke AZAMI, Kenji KAMIYA, Akira SAKAI.
- Organizer
  第65回日本放射線影響学会
- Data Source
  KAKENHI-PROJECT-20K08738
[Presentation] Analysis of differential gene expression in t(11;14) carrying iPS cells induced by genome editing2022
- Author(s)
  Naohiro Tsuyama, Kenichi Kudo, Misaki Sugai Takahashi, Yusuke Azami, Kenji Kamiya, Akira Sakai.
- Organizer
  第65回日本放射線影響学会
- Data Source
  KAKENHI-PROJECT-18K11647
[Presentation] Analysis of differential gene expression in t(11;14) carrying iPS cells induced by genome editing2022
- Author(s)
  Naohiro Tsuyama, Kenichi Kudo, Misaki Sugai Takahashi, Yusuke Azami, Kenji Kamiya, Akira Sakai.
- Organizer
  第65回日本放射線影響学会
- Data Source
  KAKENHI-PROJECT-21K07681
[Presentation] Study for exploring myeloma-initiating cell using normal B cell-derived iPS cells.2021
- Author(s)
  Yusuke Azami, Naohiro Tsuyama, Yu Abe, Misaki Sugai-Takahashi, Ken-ichi Kudo, Miwa Fukami, Akinobu Ota, Karnan Sivasundaram, Moe Muramatsu, Tomonari Shigemura, Megumi Sasatani, Yuko Hashimoto, Shigehira Saji, Kenji Kamiya, Ichiro Hanamura, Takayuki Ikezoe, Masafumi Onodera, Akira Sakai
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07681
[Presentation] Optimization of chromosome specimen preparation for biodosimetry using chromosome aberration frequency.2021
- Author(s)
  Naohiro Tsuyama, Yu Abe, Misaki Sugai-Takahashi, Kenichi Kudo, Yusuke Azami, Miwa Fukami, Tomisato Miura, Kenji Kamiya, Akira Sakai
- Organizer
  第64回日本放射線影響学会
- Data Source
  KAKENHI-PROJECT-18K11647
[Presentation] 正常Bリンパ球由来iPS細胞を用いた骨髄腫起源細胞の探索2021
- Author(s)
  坂井　晃
- Organizer
  第46回日本骨髄腫学会学術集会　会長講演
- Invited
- Data Source
  KAKENHI-PROJECT-20K08738
[Presentation] Optimization of chromosome specimen preparation for biodosimetry using chromosome aberration frequency.2021
- Author(s)
  Naohiro Tsuyama, Yu Abe, Misaki Sugai-Takahashi, Kenichi Kudo, Yusuke Azami, Miwa Fukami, Tomisato Miura, Kenji Kamiya, Akira Sakai
- Organizer
  第64回日本放射線影響学会
- Data Source
  KAKENHI-PROJECT-21K07681
[Presentation] Study for exploring myeloma-initiating cell using normal B cell-derived iPS cells.2021
- Author(s)
  Yusuke Azami, Naohiro Tsuyama, Yu Abe, Misaki Sugai-Takahashi, Ken-ichi Kudo, Miwa Fukami, Akinobu Ota, Karnan Sivasundaram, Moe Muramatsu, Tomonari Shigemura, Megumi Sasatani, Yuko Hashimoto, Shigehira Saji, Kenji Kamiya, Ichiro Hanamura, Takayuki Ikezoe, Masafumi Onodera, Akira Sakai
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K11647
[Presentation] Study for exploring myeloma-initiating cell using normal B cell-derived iPS cells2021
- Author(s)
  Yusuke Azami, Naohiro Tsuyama, Yu Abe, Misaki Sugai-Takahashi, Ken-ichi Kudo, Miwa Fukami, Akinobu Ota, Karnan Sivasundaram, Moe Muramatsu, Tomonari Shigemura, Megumi Sasatani, Yuko Hashimoto, Shigehira Saji, Kenji Kamiya, Ichiro Hanamura, Takayuki Ikezoe, Masafumi Onodera, Akira Sakai
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08738
[Presentation] Chromosomal Translocation t(11;14) Induced by the Cre-loxP System in Normal B cell-derived iPS Cells for the Study of Myeloma-initiating Cells.2020
- Author(s)
  Misaki Sugai, Naohiro Tsuyama, Yu Abe, Yusuke Azami, Kenichi Kudo, Akinobu Ota, Karnan Sivasundaram, Moe Muramatsu, Tomonari Shigemura, Megumi Sasatani, Yuko Hashimoto, Kenji Kamiya, Ichiro Hanamura, Takayuki Ikezoe, Masafumi Onodera, Akira Sakai.
- Organizer
  62th ASH Annual Meeting.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11647
[Presentation] Investigation of naturally occurring chromosome aberrations and individual radiosensitivity in Japanese.2020
- Author(s)
  Yu Abe, Misaki Sugai, Naohiro Tsuyama, Ken-ichi Kudo, Yusuke Azami, Akira Sakai
- Organizer
  第63回日本放射線影響学会
- Data Source
  KAKENHI-PROJECT-18K11647
[Presentation] Chromosomal translocation t(11;14) induced by Cre-loxP system in normal B cell-derived iPS cells.2020
- Author(s)
  Misaki Sugai, Naohiro Tsuyama, Yu Abe*, Yusuke Azami*, Akinobu Ota, Karnan Sivasundaram, Moe Muramatsu, Tomonari Shigemura, Megumi Sasatani, Yuko Hashimoto, Kenji Kamiya, Ichiro Hanamura, Takayuki Ikezoe, Masafumi Onodera, Akira Sakai.
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K11647
[Presentation] Induction of sequence-specific chromosomal aberration using CRISPR/Cas9 and Cre-loxP.2020
- Author(s)
  Naohiro Tsuyama, Yu Abe, Misaki Sugai, Yusuke Azami, Ken-ichi Kudo, Kenji Kamiya, Akira Sakai.
- Organizer
  第63回日本放射線影響学会
- Data Source
  KAKENHI-PROJECT-18K11647
[Presentation] Chromosomal translocation t(11;14) induced by Cre-loxP system in normal B cell-derived iPS cells2020
- Author(s)
  Misaki Sugai, Naohiro Tsuyama, Yu Abe, Yusuke Azami, Akinobu Ota, Karnan Sivasundaram, Moe Muramatsu, Tomonari Shigemura, Megumi Sasatani, Yuko Hashimoto, Kenji Kamiya, Ichiro Hanamura, Takayuki Ikezoe, Masafumi Onodera, Akira Sakai.
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08738
[Presentation] Chromosomal Translocation t(11;14) Induced by the Cre-loxP System in Normal B cell-derived iPS Cells for the Study of Myeloma-initiating Cells2020
- Author(s)
  Misaki Sugai, Naohiro Tsuyama, Yu Abe, Yusuke Azami, Kenichi Kudo, Akinobu Ota, Karnan Sivasundaram, Moe Muramatsu, Tomonari Shigemura, Megumi Sasatani, Yuko Hashimoto, Kenji Kamiya, Ichiro Hanamura, Takayuki Ikezoe, Masafumi Onodera, Akira Sakai.
- Organizer
  62th ASH Annual Meeting
- Data Source
  KAKENHI-PROJECT-20K08738
[Presentation] Induction of t(11;14) IgH enhancer/promoter-cyclin D1 gene translocation using CRISPR/Cas9.2019
- Author(s)
  Naohiro Tsuyama, Yu Abe, Aki Yanagi, Misaki Sugai, Kenji Kamiya, Akira Sakai
- Organizer
  放射線災害・医科学研究拠点第３回国際シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11647
[Presentation] Analysis of the number of chromosome aberrations induced by three consecutive CT examinations.2019
- Author(s)
  Yu Abe, Hideyoshi Noji, Misaki Sugai, Yumiko Kurosu, Naohiro Tsuyama, Aki Yanagi, Yukari Yanai, Takashi Ohba, Tetsuo Ishikawa, Tomisato Miura, Kenji Kamiya, Mitsuaki A. Yoshida, Akia Sakai
- Organizer
  放射線災害・医科学研究拠点第３回国際シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11647
[Presentation] Introduction of Chromosomal Translocation t(11; 14) and a p53 Deletion into Normal B Cell-derived iPSCs to Elucidate the Cellular Origin of Myeloma Cells.2019
- Author(s)
  Yanagi A, Tsuyama N, Sugai M, Abe Y, Azami Y, Yanai Y, Ota A, Sivasundaram K, Muramatsu M, Shigemura T, Sasatani M, Hashimot Y, Kamiya K, Hanamura I, Ikezoe T, Onodera M, Sakai A
- Organizer
  61th ASH Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11647
[Presentation] CRISPR/Cas9を用いた染色体転座t(11;14) 誘導系の作製と染色体異常解析への応用2019
- Author(s)
  津山尚宏、阿部悠、柳亜紀、菅井美咲、神谷研二、坂井晃
- Organizer
  第4回放射線災害・医科学研究拠点カンファランス
- Data Source
  KAKENHI-PROJECT-18K11647
[Presentation] CRISPR/Cas9を用いた配列特異的DNA二本鎖切断と染色体異常の解析2019
- Author(s)
  Naohiro Tsuyama, Yu Abe, Aki Yanagi, Misaki Sugai, Kenji Kamiya, Akira Sakai
- Organizer
  第61回日本放射線影響学会
- Data Source
  KAKENHI-PROJECT-18K11647
[Presentation] Chromosomal translocation t(11;14) and p53 deletion in B cell-derived iPS cells by CRISPR/Cas9.2019
- Author(s)
  Aki Yanagi, Naohiro Tsuyama, Misaki Sugai, Yu Abe, Yukari Yanai, Akinobu Ota, Karnan Sivasundaram, Lobna Alkebsi, Moe Muramatsu, Tomonari Shigemura, Megumi Sasatani, Yuko Hashimoto, Kenji Kamiya, Ichiro Hanamura, Takayuki Ikezoe, Masafumi Onodera, Akira Sakai
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K11647
[Presentation] Construction of dose response curves for cytogenetic biodosimetry in the low dose range based on five persons.2018
- Author(s)
  Yu Abe, Mitsuaki A Yoshida, Kurumi Fujioka, Yumiko Kurosu, Risa Ujiie, Aki Yanagi, Naohiro Tsuyama, Tomisato Miura, Toshiya Inaba, Kenji Kamiya, Akira Sakai
- Organizer
  EPRBioDose 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11647
[Presentation] CRISPR/Cas9を用いたt(11; 14)染色体転座誘発2018
- Author(s)
  津山尚宏、阿部悠、柳亜紀、菅井美咲、神谷研二、坂井晃
- Organizer
  第61回日本放射線影響学会
- Data Source
  KAKENHI-PROJECT-18K11647
[Presentation] Attempt to prove the existence of abnormal B lymphocyte as myeloma-initiating cells from B cell-derived induced pluripotent stem cells.2018
- Author(s)
  Yanagi A, Tsuyama N, Yanai Y, Abe Y, Sugai M, Ota A, Sivasundaram K, Shigemura T, Sasatani M, Kamiya K, Hanamura I, Ikezoe T, Onodera M, Sakai A
- Organizer
  60th ASH Annual Meeting.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11647
[Presentation] Analysis of the number of chromosome aberrations induced by three consecutive CT examinations.2018
- Author(s)
  Abe Y, Noji H, Sugai M, Kurosu Y, Tsuyama N, Yanagi A, Yanai Y, Ohba T, Ishikawa T, Miura T, Kamiya K, Yoshida MA, Sakai A.
- Organizer
  第61回日本放射線影響学会.
- Data Source
  KAKENHI-PROJECT-16K08970
[Presentation] Investigation of the cumulative number of chromosome aberrations induced by three consecutive CT scans.2018
- Author(s)
  Yu Abe, Hideyoshi Noji, Misaki Sugai, Yumiko Kurosu, Takashi Ohba, Naohiro Tsuyama, Aki Yanagi, Yukari Yanai, Tetsuo Ishikawa, Tomisato Miura, Kenji Kamiya, Mitsuaki A Yoshida, Akira Sakai.
- Organizer
  American Association for Cancer Research Annual Meeting 2018.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08970
[Presentation] Investigation of the cumulative number of chromosome aberrations induced by three consecutive CT scans.2018
- Author(s)
  Yu Abe, Hideyoshi Noji, Misaki Sugai, Yumiko Kurosu, Takashi Ohba, Naohiro Tsuyama, Aki Yanagi, Yukari Yanai, Tetsuo Ishikawa, Tomisato Miura, Kenji Kamiya, Mitsuaki A Yoshida, Akira Sakai
- Organizer
  American Association for Cancer Research Annual Meeting 2018.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11647
[Presentation] Construction of dose response curves for cytogenetic biodosimetry in the low dose range based on five persons.2018
- Author(s)
  Yu Abe, Mitsuaki A Yoshida, Kurumi Fujioka, Yumiko Kurosu, Risa Ujiie, Aki Yanagi, Naohiro Tsuyama, Tomisato Miura, Toshiya Inaba, Kenji Kamiya, Akira Sakai.
- Organizer
  EPRBioDose 2018.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08970
[Presentation] Investigation of the cumulative number of chromosome aberrations induced by three consecutive CT scans2018
- Author(s)
  阿部　悠、野地秀義、菅井美咲、黒須由美子、津山尚宏、柳　亜希、柳井祐佳里、大葉　隆、石川徹夫、三浦富智、神谷研二、吉田光明、坂井　晃
- Organizer
  2018年アメリカがん学会 (AACR)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08970
[Presentation] ttempt to make abnormal B lymphocytes as myeloma-initiating cells from iPSs.2018
- Author(s)
  柳　亜希、津山尚宏、柳井祐佳里、阿部　悠、菅井美咲、太田明伸、シバスンダラン　カルナン、笹谷めぐみ、神谷研二、花村一朗、池添隆之、小野寺雅史、坂井　晃
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K11647
[Presentation] Attempt to make abnormal B lymphocytes as myeloma-initiating cells from iPSs.2018
- Author(s)
  柳　亜希、津山尚宏、柳井祐佳里、阿部　悠、菅井美咲、太田明伸、シバスンダラン　カルナン、笹谷めぐみ、神谷研二、花村一朗、池添隆之、小野寺雅史、坂井　晃.
- Organizer
  第80回日本血液学会学術集会.
- Data Source
  KAKENHI-PROJECT-16K08970
[Presentation] Attempt to prove the existence of abnormal B lymphocyte as myeloma-initiating cells from B cell-derived induced pluripotent stem cells.2018
- Author(s)
  Yanagi A, Tsuyama N, Yanai Y, Abe Y, Sugai M, Ota A, Sivasundaram K, Shigemura T, Sasatani M, Kamiya K, Hanamura I, Ikezoe T, Onodera M, Sakai A.
- Organizer
  60th ASH Annual Meeting.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08970
[Presentation] CRISPR/Cas9を用いたt(11; 14)染色体転座誘発.2018
- Author(s)
  津山尚宏、阿部悠、柳亜紀、菅井美咲、坂井晃.
- Organizer
  61回日本放射線影響学会.
- Data Source
  KAKENHI-PROJECT-16K08970
[Presentation] Analysis of the number of chromosome aberrations induced by three consecutive CT examinations.2018
- Author(s)
  Abe Y, Noji H, Sugai M, Kurosu Y, Tsuyama N, Yanagi A, Yanai Y, Ohba T, Ishikawa T, Miura T, Kamiya K, Yoshida MA, Sakai A
- Organizer
  第61回日本放射線影響学会
- Data Source
  KAKENHI-PROJECT-18K11647
[Presentation] 継続的なCT検査による染色体異常形成数の累積生の検討2017
- Author(s)
  阿部　悠、菅井美咲、黒須由美子、津山尚宏、柳　亜希、柳井祐佳里、吉田光明、大葉　隆、野地秀義、石川徹夫、神谷研二、坂井　晃
- Organizer
  第60回日本放射線影響学会
- Data Source
  KAKENHI-PROJECT-16K08970
[Presentation] 低線量γ線照射による細胞遺伝学的線量評価用線量応答曲線の作製2016
- Author(s)
  阿部悠, 三浦富智, 吉田光明, 氏家里紗, 黒須由美子, 柳亜希，津山尚宏, 川村文彦, 藤岡来実, 稲葉俊哉, 神谷研二，坂井晃
- Organizer
  日本放射線影響学会第59回大会
- Place of Presentation
  JMSアステールプラザ, 広島県広島市
- Year and Date
  2016-10-28
- Data Source
  KAKENHI-PROJECT-26293270
[Presentation] Analyses of dicentric chromosome formation and chromosomal translocation after a single CT scan in adults2015
- Author(s)
  Yu Abe, Tomisato Miura, Mitsuaki A Yoshida, Risa Ujiie, Yumiko Kurosu, Nagisa Kato, Atsushi Katafuchi, Naohiro Tsuyama, Takashi Ohba, Tomoko Inamasu, Fumio Shishido, Hideyoshi Noji, Kazuei Ogawa, Hiroshi Yokouchi, Kenya Kanazawa, Takashi Ishida, Jun Ohsugi, Hiroyuki Suzuki, Tetsuo Ishikawa, Kenji Kamiya, Akira Sakai
- Organizer
  ICRR（国際放射線影響学会）
- Place of Presentation
  京都
- Year and Date
  2015-05-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460694
[Presentation] Analyses of dicentric chromosome formation and chromosomal translocation after a single CT scan in adults2015
- Author(s)
  Yu Abe, Tomisato Miura, Mitsuaki A Yoshida, Risa Ujiie, Yumiko Kurosu, Nagisa Kato, Atsushi Katafuchi, Naohiro Tsuyama, Takashi Ohba, Tomoko Inamasu, Fumio Shishido, Hideyoshi Noji, Kazuei Ogawa, Hiroshi Yokouchi, Kenya Kanazawa, Takashi Ishida, Jun Ohsugi, Hiroyuki Suzuki, Tetsuo Ishikawa, Kenji Kamiya, Akira Sakai
- Organizer
  15th International Congress of Radiation Research
- Place of Presentation
  Kyoto
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-25460694
[Presentation] Interrelationships between 3T-MRI-, 64-section-MDCT-, and micro-CT-derived trabecular bone structure parameters: a study in cadavers2014
- Author(s)
  2) Takasu M, Kaichi Y, Akiyama Y, Date S, Sakai A, Kuroda Y, Awai K
- Organizer
  22thAnnual Meeting and Exhibition of International Society for Magnetic Resonance in Medicine
- Place of Presentation
  Milan, Italy
- Data Source
  KAKENHI-PROJECT-23591768
[Presentation] Analysis of dicentric chromosomes induced by CT examination2014
- Author(s)
  阿部　悠, 氏家理紗、黒須由美子、片渕　淳、津山尚宏、大葉　隆、宍戸文男、野地秀義、小川一英、金沢賢也、横内　浩、石田　卓、大杉　純、鈴木弘行、吉田光明、神谷研二、坂井　晃
- Organizer
  第57回日本放射線影響学会
- Place of Presentation
  鹿児島
- Year and Date
  2014-10-01
- Data Source
  KAKENHI-PROJECT-25460694
[Presentation] Magnetic Resonance Evaluation of Multiple Myeloma at 3.0 Tesla: How Do Bone Marrow Plasma Cell Percentage and Selection of Protocols Affect Lesion Conspicuity?2014
- Author(s)
  1) Takasu M, Kaichi Y, Tani C, Date S, Akiyama Y, Kuroda Y, Sakai A, Awai K
- Organizer
  22thAnnual Meeting and Exhibition of International Society for Magnetic Resonance in Medicine
- Place of Presentation
  Milan, Italy
- Data Source
  KAKENHI-PROJECT-23591768
[Presentation] Can IDEAL-MR Imaging of Multiple Myeloma Be Used as a Biomarker for Predicting Symptomatic Myeloma?2013
- Author(s)
  4) Takasu M, Kaichi Y, Ishikawa M, Date S, Akiyama Y, Awai K, Kuroda Y, Sakai A
- Organizer
  99th Scientific Assembly and Annual Meeting of Radiological Society of North America
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-23591768
[Presentation] Longitudinal CT Study of Lenalidomide and Bortezomib Treatment for Multiple Myeloma: Trabecular Microarchitecture and Biomechanics Assessed by a CT-based Finite Element Model2013
- Author(s)
  3) Takasu M, Kaichi Y, Ishikawa M, Date S, Kiguchi M, Awai K, Kuroda Y, Sakai A
- Organizer
  99th Scientific Assembly and Annual Meeting of Radiological Society of North America
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-23591768
[Presentation] MR Evaluation of Multiple Myeloma at 3.0 T: How Does Protocol Selection Affect Lesion Conspicuity?2012
- Author(s)
  Miyuki Takasu, Yoko Kaichi, Keizo Tanitame, Shuji Date, Yuji Akiyama, Kazuo Awai, Yoshiaki Kuroda, Akira Sakai
- Organizer
  RSNA 99th Scientific Assembly and Annual Meeting
- Place of Presentation
  Chicago, America
- Data Source
  KAKENHI-PROJECT-23591768
[Presentation] Patients with Multiple Myeloma: Finite Element Analysis Using Multidetector CT to Predict Pathological Fracture2012
- Author(s)
  Miyuki Takasu, Toru Higaki, Chihiro Tani, Masao Kiguchi, Fuminari Tatsugami, Kazuo Awai, Yoshiaki Kuroda, Akira Sakai
- Organizer
  RSNA 99th Scientific Assembly and Annual Meeting
- Place of Presentation
  Chicago, America
- Data Source
  KAKENHI-PROJECT-23591768
[Presentation] 多発性骨髄腫における脊椎海綿骨微細構造の変化2012
- Author(s)
  高須深雪, 谷千尋, 石川美保, 中村優子, 本田有紀子, 迫田慈子, 伊達秀二, 麻奥英毅, 坂井晃, 粟井和夫
- Organizer
  第71回日本医学放射線学会総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23591768
[Presentation] Iterative Decomposition of Water and Fat with Echo Asymmetry and Least-Squares Estimation (IDEAL) Imaging of Multiple Myeloma: Discriminant Analysis for Differentiation of Tumor Staging2012
- Author(s)
  Miyuki Takasu, Chihiro Tani, Miho Ishikawa, Daisuke Komoto, Keizo Tanitame, Yuji Akiyama, Yoshiaki Kuroda, Akira Sakai, Kazuo Awai
- Organizer
  ISMRM 20st Annual Meeting & Exhibition
- Place of Presentation
  Melbourne, Australia
- Data Source
  KAKENHI-PROJECT-23591768
[Presentation] 多列検出器CTを用いた多発性骨髄腫の海綿骨骨梁解析：preliminary results2011
- Author(s)
  高須深雪(広島大学/放射線診断科), 赤澤由美子, 迫田慈子, 谷千尋, 石川美保, 粟井和夫, 田村彰久, 坂井晃
- Organizer
  第70回日本医学放射線学会学術発表会
- Place of Presentation
  Web開催
- Data Source
  KAKENHI-PROJECT-23591768

1. 阿部悠 (00722472)

# of Collaborated Projects: 5 results

# of Collaborated Products: 39 results
2. YOSHIDA Mitsuaki (60182789)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
3. Tsuyama Naohiro (10335747)

# of Collaborated Projects: 3 results

# of Collaborated Products: 33 results
4. TANAKA Hideo (50243613)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TAKASU Miyuki (70565647)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
6. TANAKA Nobuhiro (20363062)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. AWAI Kazuo (30294573)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
8. KATAFUCHI Atsushi (40634910)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. OGAWA Kazuei (40423800)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. Miura Tomisato (20261456)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. SHIMOSE Shouji (30304439)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. OCHI Mitsuo (70177244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. YASUNAGA Yuji (40253075)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KUBO Tadahiko (70397959)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 葛西宏介 (50400148)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 中田章史 (70415420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 野地秀義 (20347214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
18. 柳亜希 (60803525)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
19. 工藤健一 (00805799)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

Sakai Akira 坂井 晃

SAKAI Akira 坂井 晃

坂井 昇 サカイ ノボル

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標的ゲノム編集/系統的ノックダウンによる染色体転座頻度を増加させる因子の探索

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How does aberrant B lymphocyte produce a origin of multiple myeloma cells?Principal Investigator

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Analysis of micronucleus/chromotrypsis formation process by inducible Dic.

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Analysis of influence of medical radiation exposure on chromosome by CT examination and biological dose evaluationPrincipal Investigator

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Application of cell cycle progression index to radiosensitivity evaluation and analysis of background factors on chromosome aberration

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Establishment of biological dose assessment method using the chromosome analysis in low-dose radiation exposure.Principal Investigator

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Vertebral fracture risk in osteoporosis assessed by a multidetector CT-based trabecular structure analysis

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Mechanisms of imatinib-resistance in clinical patients and imatinib-resistant cell line showing over-expression of Lyn in chronic myelogenous leukemia (CML)Principal Investigator

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Inhibitory effects of a new bisphosphonate, minodronate, on proliferation and invasion of a variety of malignant bone tumor cells

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The significant role for the loss of CD27-expression in myelomagenesisPrincipal Investigator

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[Book] 多発性骨髄腫の進展と遺伝子不安定性.2018

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[Journal Article] No increase in translocated chromosomal aberrations, an indicator of ionizing radiation exposure, in childhood thyroid cancer in Fukushima Prefecture.2023

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[Journal Article] Chromosomal translocation t(11;14) and p53 deletion induced by the CRISPR/Cas9 system in normal B cell-derived iPS cells2021

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Sakai Akira 坂井晃

SAKAI Akira 坂井晃

坂井昇サカイノボル