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Yokoyama Masaru  横山 勝

ORCIDConnect your ORCID iD *help
Researcher Number 70296028
Other IDs
Affiliation (Current) 2025: 国立健康危機管理研究機構, 国立感染症研究所 病原体ゲノム解析研究センター, 主任研究員
Affiliation (based on the past Project Information) *help 2024: 国立感染症研究所, 病原体ゲノム解析研究センター, 主任研究官
2016 – 2018: 国立感染症研究所, 病原体ゲノム解析研究センター, 主任研究官
Review Section/Research Field
Principal Investigator
Virology
Except Principal Investigator
Basic Section 54030:Infectious disease medicine-related
Keywords
Principal Investigator
分子・構造 / スペクトラルクラスタリング / セクター / ランダム行列理論 / 統計的カップリング行列 / 揺らぎ / エンベロープ / HIV-1
Except Principal Investigator
超保存残基 / エンベロープ / HIV-1
  • Research Projects

    (2 results)
  • Research Products

    (38 results)
  • Co-Researchers

    (11 People)
  •  超保存脆弱部位を基盤とする抗エンベロープウイルスプラットフォーム技術の構築

    • Principal Investigator
      野間口 雅子
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 54030:Infectious disease medicine-related
    • Research Institution
      The University of Tokushima
  •  Estimation of structural and statistical sectors of HV-1 Env trimer by random matrix theoryPrincipal Investigator

    • Principal Investigator
      Yokoyama Masaru
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      National Institute of Infectious Diseases

All 2019 2018 2017 2016

All Journal Article Presentation

  • [Journal Article] Concomitant enhancement of HIV-1 replication potential and neutralization-resistance in concert with three adaptive mutations in Env V1/C2/C4 domains.2019

    • Author(s)
      Doi N, Yokoyama M, Koma T, Kotani O, Sato H, Adachi A, Nomaguchi M.
    • Journal Title

      Frontiers in Microbiology

      Volume: 10 Pages: 2510-2510

    • DOI

      10.3389/fmicb.2019.00002

    • NAID

      120006937678

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08860, KAKENHI-PROJECT-17H06907, KAKENHI-PROJECT-16K08824
  • [Journal Article] Critical Contribution of Tyr15 in the HIV-1 Integrase (IN) in Facilitating IN Assembly and Nonenzymatic Function through the IN Precursor Form with Reverse Transcriptase.2017

    • Author(s)
      Takahata T, Takeda E, Tobiume M, Tokunaga K, Yokoyama M, Huang YL, Hasegawa A, Shioda T, Sato H, Kannagi M, Masuda T.
    • Journal Title

      J Virol

      Volume: 91 Issue: 1

    • DOI

      10.1128/jvi.02003-16

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05194, KAKENHI-PROJECT-15K15139, KAKENHI-PROJECT-16K08824
  • [Journal Article] A Proposal for a Structural Model of the Feline Calicivirus Protease Bound to the Substrate Peptide under Physiological Conditions2017

    • Author(s)
      Yokoyama Masaru、Oka Tomoichiro、Takagi Hirotaka、Kojima Hirotatsu、Okabe Takayoshi、Nagano Tetsuo、Tohya Yukinobu、Sato Hironori
    • Journal Title

      Frontiers in Microbiology

      Volume: 8 Pages: 1383-1383

    • DOI

      10.3389/fmicb.2017.01383

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08824, KAKENHI-PROJECT-15K07734
  • [Journal Article] Inhibition of CRM1-mediated nuclear export of influenza A nucleoprotein and nuclear export protein as a novel target for antiviral drug development.2017

    • Author(s)
      Chutiwitoonchai N, Mano T, Kakisaka M, Sato H, Kondoh Y, Osada H, Kotani O, Yokoyama M, Sato H, Aida Y
    • Journal Title

      Virology

      Volume: 507 Pages: 32-39

    • DOI

      10.1016/j.virol.2017.04.001

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15F15416, KAKENHI-PROJECT-26350976, KAKENHI-PROJECT-16K08824
  • [Journal Article] Production of HIV-1 vif mRNA Is Modulated by Natural Nucleotide Variations and SLSA1 RNA Structure in SA1D2prox Genomic Region2017

    • Author(s)
      Nomaguchi Masako、Doi Naoya、Yoshida Tomoya、Koma Takaaki、Adachi Shun、Ode Hirotaka、Iwatani Yasumasa、Yokoyama Masaru、Sato Hironori、Adachi Akio
    • Journal Title

      Frontiers in Microbiology

      Volume: 8 Pages: 2542-2542

    • DOI

      10.3389/fmicb.2017.02542

    • NAID

      120006937675

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08824, KAKENHI-PROJECT-17K08860, KAKENHI-PROJECT-17K08872, KAKENHI-PROJECT-15H04740, KAKENHI-PROJECT-17H06907
  • [Journal Article] Molecular dynamics simulation of the influenza A(H3N2) hemagglutinin trimer reveals the structural basis for adaptive evolution of the recent epidemic clade 3C.2a2017

    • Author(s)
      Yokoyama M, Fujisaki S, Shirakura M, Watanabe S, Odagiri T, Ito K, Sato H
    • Journal Title

      Frontiers in Microbiology

      Volume: 8 Pages: 584-584

    • DOI

      10.3389/fmicb.2017.00584

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08824, KAKENHI-PROJECT-16H02863
  • [Journal Article] Evolutionary constraints on the norovirus pandemic variant GII.4_2006b over the five-year persistence in Japan2017

    • Author(s)
      Sato H, Yokoyama M, Nakamura H, Oka T, Katayama K, Takeda N, Noda M, Tanaka T, Motomura K
    • Journal Title

      Frontiers in Microbiology

      Volume: 8 Pages: 410-410

    • DOI

      10.3389/fmicb.2017.00410

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08824, KAKENHI-PROJECT-17K19874
  • [Journal Article] Deletion of a 197-Amino-Acid Region in the N-Terminal Domain of Spike Protein Attenuates Porcine Epidemic Diarrhea Virus in Piglets2017

    • Author(s)
      Hou Yixuan、Lin Chun-Ming、Yokoyama Masaru、Yount Boyd L.、Marthaler Douglas、Douglas Arianna L.、Ghimire Shristi、Qin Yibin、Baric Ralph S.、Saif Linda J.、Wang Qiuhong
    • Journal Title

      Journal of Virology

      Volume: 91 Issue: 14

    • DOI

      10.1128/jvi.00227-17

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08824
  • [Journal Article] Functional receptor molecules CD300lf and CD300ld within the CD300 family enable murine noroviruses to infect cells2016

    • Author(s)
      Haga K, Fujimoto A, Takai-Todaka R , Miki M, Doan YH, Murakami K, Yokoyama M, Murata K, Nakanishi A, & Katayama K
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 113 Issue: 41

    • DOI

      10.1073/pnas.1605575113

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PUBLICLY-16H00786, KAKENHI-PROJECT-16K08824
  • [Journal Article] Novel mutant human immunodeficiency virus type 1 strains with high degree of resistance to cynomolgus macaque TRIMCyp generated by randam mutagenesis.2016

    • Author(s)
      Sultana, T., Nakayama, E.E., Tobita, S., Yokoyama, M., Seki, Y., Saito, A., Nomaguchi, M., Adachi, A., Akari, H., Sato, H., and Shioda, T.
    • Journal Title

      Journal of General Virology

      Volume: 97 Issue: 4 Pages: 963-976

    • DOI

      10.1099/jgv.0.000408

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26460556, KAKENHI-PROJECT-25670218, KAKENHI-PROJECT-26293104, KAKENHI-PROJECT-16H05194, KAKENHI-PROJECT-16K08824
  • [Journal Article] Intracerebral inoculation of mouse-passaged Saffold virus type 3 affects cerebellar development in neonatal mice.2016

    • Author(s)
      Kotani O, Suzuki T, Yokoyama M, Iwata-Yoshikawa N, Nakajima N, Sato H, Hasegawa H, Taguchi F, Shimizu H, Nagata N.
    • Journal Title

      J Virol

      Volume: pii: JVI. Issue: 21 Pages: 00864-16

    • DOI

      10.1128/jvi.00864-16

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26860307, KAKENHI-PROJECT-15K08511, KAKENHI-PROJECT-16K08824, KAKENHI-PROJECT-16H05200
  • [Journal Article] Molecular Mechanism of HIV-1 Vpr for Binding to Importin-α.2016

    • Author(s)
      Miyatake H., Sanjoh A., Murakami T., Murakami H., Matsuda G., Hagiwara K., Yokoyama M., Sato H., Miyamoto Y., Dohmae N., Aida Y.
    • Journal Title

      J. Mol. Biol.

      Volume: 428 Issue: 13 Pages: 2744-2757

    • DOI

      10.1016/j.jmb.2016.05.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K07068, KAKENHI-PROJECT-16K08824
  • [Journal Article] Increased HIV-1 Sensitivity to Neutralizing Antibodies by Mutations in The Env V3-Coding Region for Resistance to CXCR4 Antagonists2016

    • Author(s)
      Hikichi Y, Yokoyama M, Takemura T, Fujino M, Kumakura S, Maeda Y, Yamamoto N, Sato H, Matano T, Murakami T
    • Journal Title

      Journal of General Virology

      Volume: 97 Issue: 9 Pages: 2427-2440

    • DOI

      10.1099/jgv.0.000536

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08824, KAKENHI-PROJECT-16K09938
  • [Journal Article] SL1 revisited: functional analysis of the structure and conformation of HIV-1 genome RNA.2016

    • Author(s)
      Sakuragi S, Yokoyama M, Shioda T, Sato H, Sakuragi JI.
    • Journal Title

      Retrovirology

      Volume: 13 Issue: 1 Pages: 79-79

    • DOI

      10.1186/s12977-016-0310-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05194, KAKENHI-PROJECT-16K08810, KAKENHI-PROJECT-16K08824
  • [Journal Article] Enhanced antibody-mediated neutralization of HIV-1 variants that are resistant to fusion inhibitors2016

    • Author(s)
      Alam, M., Kuwata, T., Shimura, K., Yokoyama, M., Ramirez Valdez, K. P., Tanaka, K., Maruta, Y., Oishi, S., Fujii, N., Sato, H., Matsuoka M. and Matsushita S.
    • Journal Title

      Retrovirology

      Volume: 13 Issue: 1 Pages: 70-70

    • DOI

      10.1186/s12977-016-0304-7

    • NAID

      120005973385

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26430091, KAKENHI-PROJECT-16K08824, KAKENHI-PROJECT-15H04654, KAKENHI-PROJECT-15H04870
  • [Presentation] 1.Role for the Gag-CA linker domain in the late HIV-1 replication phase2018

    • Author(s)
      Koma T,Kotani O,Doi N,Miyakawa K,Ryo A,Yokoyama M,Sato H,Adachi A,Nomaguchi M
    • Organizer
      第66回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K08824
  • [Presentation] 3.HIV-1 エンベロープ三量体における中和感受性に関連する構造とゆらぎ2018

    • Author(s)
      横山 勝,佐藤裕徳
    • Organizer
      第32回日本エイズ学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-16K08824
  • [Presentation] 4.Characterization of novel HIV-1 inhibitors targeting Gag-TSG101 interaction2018

    • Author(s)
      Siarot Lowela,Chutiwitoonchai Nopporn,佐藤洋隆,Chang Hao,小谷 治,横山 勝,佐藤裕徳,藤野真之,村上 勉,近藤恭光,本田香,長田裕之,上田一樹,伊藤嘉浩,青野俊裕,児玉栄一,黒田和道,武井正美,間 陽子
    • Organizer
      第32回日本エイズ学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-16K08824
  • [Presentation] 網羅的 Env 標的阻害剤ライブラリーの構築-32018

    • Author(s)
      原田恵嘉、野村 渉、鳴海哲夫、横山 勝、前田賢次、竹内怜音、紺野奇重、引地優太、佐藤裕徳、玉村啓和、俣野哲朗、吉村和久
    • Organizer
      第32回日本エイズ学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-16K08824
  • [Presentation] 5.A proposal of molecular dynamics based structural models of the Pr55Gag precursor of HIV-12018

    • Author(s)
      Kotani O,Yokoyama M,Ono A,Sato H
    • Organizer
      第32回日本エイズ学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-16K08824
  • [Presentation] Discovery of novel bifunctional entry inhibitors of HIV-1 using structure-based in silico screening2017

    • Author(s)
      Shigeyoshi Harada, Masaru Yokoyama, Kasumi Ogihara, Yuta Hikichi, Hironori Sato, Tetsuo Narumi, Tetsuro Matano, Kazuhisa Yoshimura
    • Organizer
      第65回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K08824
  • [Presentation] 分子動力学計算を用いた抗HIVウイルス物質の作用機構解析2017

    • Author(s)
      小谷 治、横山 勝、Lowela Siarot、佐藤洋隆、Nopporn Chutiwitoonchai、間 陽子、佐藤裕徳
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Data Source
      KAKENHI-PROJECT-16K08824
  • [Presentation] 網羅的Env標的阻害剤ライブラリーの構築-22017

    • Author(s)
      原田恵嘉、野村 渉、鳴海哲夫、横山 勝、前田賢次、林 宏典、紺野奇重、引地優太、佐藤裕徳、玉村啓和、俣野哲朗、吉村和久
    • Organizer
      第31回日本エイズ学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-16K08824
  • [Presentation] 分子動力学計算によるHIV-1 エンベロープ三量体の構造セクターの解析2017

    • Author(s)
      横山 勝、佐藤裕徳
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Data Source
      KAKENHI-PROJECT-16K08824
  • [Presentation] Analysis of mechanism of action of antivirals targeting HIV-1 Gag p62017

    • Author(s)
      小谷 治、横山 勝、Loela Siarot、佐藤洋隆、Nopporn Chutiwitoonchai、間 陽子、佐藤裕徳
    • Organizer
      第65回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K08824
  • [Presentation] HIV-1 エンベロープ三量体における中和抗体逃避機構の解析2017

    • Author(s)
      横山 勝、佐藤裕徳
    • Organizer
      第31回日本エイズ学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-16K08824
  • [Presentation] HIVの細胞侵入を阻害するオレアノール酸誘導体の構造活性相関研究2017

    • Author(s)
      荻原香澄、引地優太、原田恵嘉、横山 勝、加藤由奈、佐藤浩平、間瀬暢之、吉村和久、鳴海哲夫
    • Organizer
      第27回抗ウイルス療法学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-16K08824
  • [Presentation] HIV-1インテグラーゼ非酵素的機能の分子基盤2017

    • Author(s)
      増田貴夫、高畑辰郎、黄 渝倫、王 寶れい、長谷川温彦、徳永研三、飛梅 実、塩田達夫、武田英里、俣野哲朗、横山 勝、河合剛太、佐藤裕徳、神奈木真理
    • Organizer
      第31回日本エイズ学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-16K08824
  • [Presentation] タンパク質構造情報を用いたインフルエンザウイルス・ヘマグルチニンの受容体指向性解析2017

    • Author(s)
      奥田 萌、横山 勝、佐藤裕徳、由良 敬
    • Organizer
      第6回日本生物物理学会関東支部会
    • Place of Presentation
      早稲田大学TWIns(東京都新宿区)
    • Year and Date
      2017-03-13
    • Data Source
      KAKENHI-PROJECT-16K08824
  • [Presentation] Structural sectors that are contributed to neutralization escape in HIV-1 envelope glycoprotein trimer2017

    • Author(s)
      横山 勝、佐藤裕徳
    • Organizer
      第65回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K08824
  • [Presentation] Molecular mechanism of inhibition by a new compound DP2392-E10 against influenza virus replication2016

    • Author(s)
      CHUTIWITOONCHAI N, KAKISAKA M, MANO T, SATO H, KOTANI O, YOKOYAMA M, SATO H, AIDA Y
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学生物資源科学部(神奈川県藤沢市)
    • Year and Date
      2016-09-06
    • Data Source
      KAKENHI-PROJECT-16K08824
  • [Presentation] HIV-1 Env三量体における制限された構造ゆらぎ2016

    • Author(s)
      横山 勝、奥田 萌、中村浩美、小谷 治、由良 敬、佐藤裕徳
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-16K08824
  • [Presentation] ノロウイルスカプシドにおける構造ゆらぎと相関運動2016

    • Author(s)
      横山 勝、奥田 萌、中村浩美、小谷 治、由良 敬、佐藤裕徳
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-10-23
    • Data Source
      KAKENHI-PROJECT-16K08824
  • [Presentation] HIV envelopeの構造と動的性質2016

    • Author(s)
      横山 勝
    • Organizer
      第30回日本エイズ学会学術集会・総会
    • Place of Presentation
      かごしま県民交流センター(鹿児島県鹿児島市)
    • Year and Date
      2016-11-24
    • Data Source
      KAKENHI-PROJECT-16K08824
  • [Presentation] ヒト免疫不全ウイルス1型(HIV-1) Gag と宿主因子TSG101との相互作用を標的とする新規HIV薬の開発2016

    • Author(s)
      Lowela Siarot、佐藤洋隆、Nopporn Chutiwitoonchai、小谷 治、横山 勝、佐藤裕徳、本田香織、近藤恭光、長田裕之、間 陽子
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学生物資源科学部(神奈川県藤沢市)
    • Year and Date
      2016-09-06
    • Data Source
      KAKENHI-PROJECT-16K08824
  • [Presentation] 網羅的Env標的阻害剤ライブラリーの構築-12016

    • Author(s)
      原田恵嘉、野村渉、鳴海哲夫、横山 勝、前田賢次、林宏典、荻原香澄、石田有佑、引地優太、佐藤裕徳、玉村啓和、俣野哲朗、吉村和久
    • Organizer
      第30回日本エイズ学会学術集会・総会
    • Place of Presentation
      かごしま県民交流センター(鹿児島県鹿児島市)
    • Year and Date
      2016-11-24
    • Data Source
      KAKENHI-PROJECT-16K08824
  • [Presentation] Structural Fluctuations and Correlated Motions in Norovirus Capsid Oligomer2016

    • Author(s)
      Yokoyama M, Okuda M, Nakamura H, Kotani O, Yura K, Sato H
    • Organizer
      The 6th International Calicivirus Conference
    • Place of Presentation
      Savannah (USA)
    • Year and Date
      2016-10-10
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08824
  • [Presentation] エンテロウイルス粒子形成を制御するカプシド蛋白質機能領域の予測2016

    • Author(s)
      小谷治、横山勝、佐藤裕徳
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-10-23
    • Data Source
      KAKENHI-PROJECT-16K08824
  • 1.  野間口 雅子 (80452647)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 2.  駒 貴明 (00803496)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  SUZUKI Tadaki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  KUWATA Takeo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  村田 和義
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  足立 昭夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  塩田 達雄
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 8.  宮本 洋一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  CHUTIWITOONCHAI NOPPORN
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 10.  間 陽子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  松下 修三
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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