Takagi Tsuyoshi 高木豪

… Alternative Names

高木豪タカギツヨシ

TAKAGI Tsuyoshi 高木豪

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Researcher Number	70300879
Other IDs
Affiliation (Current)	2026: 愛知県医療療育総合センター発達障害研究所, 障害モデル研究部, 主任研究員
Affiliation (based on the past Project Information) *help	2019 – 2024: 愛知県医療療育総合センター発達障害研究所, 障害モデル研究部, 主任研究員 2016 – 2018: 愛知県心身障害者コロニー発達障害研究所, 周生期学部, 主任研究員 2011 – 2012: 愛知県心身障害者コロニー発達障害研究所, 周生期学部, 主任研究員 2010: 独立行政法人理化学研究所, 石井分子遺伝学研究室, 専任研究員 2000 – 2002: 理化学研究所, 分子遺伝学研究室, 研究員
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 44020:Developmental biology-related / Pediatrics / Immunology / Immunology Except Principal Investigator Biological Sciences
Keywords	Principal Investigator 転写因子 / Zn-finger / モデルマウス / 知的障害 / 細胞分化 / 転写制御因子 / Zn-フィンガー / transcription factor / positive selection / 衝動性 … More / 多動性 / 母子隔離ストレス / 隔離ストレス / MRD43 / 社会的ストレス / 環境要因 / 抑制性ニューロン / 分化 / ソマトスタチン / 大脳皮質 / パルブアルブミン / 抑制ニューロン / 抑制性介在ニューロン / de novo変異 / マウスモデル / 脳神経疾患 / モワット・ウィルソン症候群 / 重度知的障害 / モワットウィルソン症候群 / autosomal dominant / intellectual disability / ZEB2 / de novo mutation / haploinsufficiency / Zn finger / Mowat-Wilson syndrome / クロマチン / リンパ球 / ositive selection / 免疫 / T細胞 / thymocyte / Zu-フィンガー / transcription fau / Positive seleetion / thyniocyte … More Except Principal Investigator Structure / Drosophila / Mice / Development / Transcription factors / Transcription mediators / Transcription control / Gene expression / 立体構造 / ショウジョウバエ / マウス / 発生 / 転写因子 / 転写メディエーター / 転写制御 / 遺伝子発現 Less

Effect of environmental stress on intellectual disability MRD43Principal Investigator
- Principal Investigator
  
  Tsuyoshi Takagi
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Institute for Developmental Research Aichi Developmental Disability Center
The analysis of cortical interneuron formation in mouse embryoPrincipal Investigator
- Principal Investigator
  
  Takagi Tsuyoshi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44020:Developmental biology-related
- Research Institution
  Institute for Developmental Research Aichi Developmental Disability Center
Analysis of Mowat-Wilson syndrome using model mousePrincipal Investigator
- Principal Investigator
  
  Takagi Tsuyoshi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Institute for Developmental Research Aichi Developmental Disability Center
Analysis of positive selection process during T eell development via large transcription factorPrincipal Investigator
- Principal Investigator
  
  TAKAGI Tsuyoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Institute for Developmental Research, Aichi Human Service Center
  The Institute of Physical and Chemical Research
Transcriptional control by mediators and their physiological significance
- Principal Investigator
  
  ISHII Shunsuke
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
マウスschnurri遺伝子ファミリーの胸腺T細胞の分化における機能の解析Principal Investigator
- Principal Investigator
  
  高木豪
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Immunology
- Research Institution
  The Institute of Physical and Chemical Research

All 2025 2024 2023 2022 2021 2020 2019 2018 2017 2013 2011 2010 2006 Other

All Journal Article Presentation

[Journal Article] Girdin deficiency causes developmental and epileptic encephalopathy with hippocampal sclerosis and interneuronopathy.2025
- Author(s)
  Iida M, Tanaka M, Takagi T, Matsuki T, Kimura K, Shibata K, Kobayashi Y, Mizutani Y, Kuwamura H, Yamada K, Kitaura H, Kakita A, Sakakibara M, Asai N, Takahashi M, Asai M.
- Journal Title
  
  Epilepsia
  
  Volume: 66 Issue: 2 Pages: 599-617
- DOI
  10.1111/epi.18204
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23H00434, KAKENHI-PROJECT-22K07952, KAKENHI-PROJECT-22K06062, KAKENHI-PROJECT-22K07010, KAKENHI-PROJECT-23K06495, KAKENHI-PROJECT-23K11981
[Journal Article] Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment2024
- Author(s)
  Hagihara Hideo,Iwasato Takuji (22nd in 131 total), Tsuyoshi Miyakawa et al.
- Journal Title
  
  eLife
  
  Volume: 12
- DOI
  10.7554/elife.89376.3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18245, KAKENHI-PROJECT-22K07952, KAKENHI-PROJECT-23K06162, KAKENHI-PROJECT-20H03346, KAKENHI-PROJECT-23H05476
[Journal Article] Using of de novo mutation system for study obtaining dominant type model animal2022
- Author(s)
  Takagi T, Asai M
- Journal Title
  
  Exp Anim
  
  Volume: 71
- Data Source
  KAKENHI-PROJECT-19K06684
[Journal Article] Using of de novo mutation system for study obtaining dominant type model animal2022
- Author(s)
  Takagi T, Asai M
- Journal Title
  
  Exp Anim
  
  Volume: 71
- Open Access
- Data Source
  KAKENHI-PROJECT-22K07952
[Journal Article] Introduction of a de novo Creb-binding protein gene mutation in sperm to produce a Rubinstein-Taybi syndrome model using inbred C57BL/6 mice2020
- Author(s)
  T.Takagi, Y Higashi, M Asai, S Ishii
- Journal Title
  
  Brain Research
  
  Volume: 1749 Pages: 147140-147140
- DOI
  10.1016/j.brainres.2020.147140
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06684, KAKENHI-PROJECT-17H04065
[Journal Article] Attenuated bidirectional short-term synaptic plasticity in the dentate gyrus of Schnurri-2 knockout mice, a model of schizophrenia2018
- Author(s)
  Kobayashi Katsunori、Takagi Tsuyoshi、Ishii Shunsuke、Suzuki Hidenori、Miyakawa Tsuyoshi
- Journal Title
  
  Molecular Brain
  
  Volume: 11 Issue: 1 Pages: 56-56
- DOI
  10.1186/s13041-018-0400-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09980, KAKENHI-PUBLICLY-17H05964
[Journal Article] Deficiency of Schnurri-2, a MHC enhancer binding protein, induce mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizopherenia2013
- Author(s)
  Keizo Takao, Katsunori Kobayashi, Hideo Hagihara, Koji Ohira, Hirotaka Shoji, Satoko Hattori, Hisatsugu Koshimizu, Juzoh Umemori, Keiko Toyama, Hironori K Nakamura, Mahomi Kuroiwa, Jun Maeda, Kimie Atsuzawa, Kayoko Esaki, Shun Yamaguchi, Shigeki Furuya, Tsuyoshi Takagi, Noah M Walton, Nobuhiro Hayashi, Hidenori Suzuki, Makoto Higuchi, Nobuteru Usuda, Tetsuya, Suhara, Akinori Nishi, Mitsuyuki Matsumoto, Shunsuke Ishii & Tsuyoshi Miyakawa
- Journal Title
  
  Neuropsychopharmacology
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590443
[Journal Article] Dampening of death pathways by schnurri-2 is essential for T-cell development2011
- Author(s)
  Staton TL, Lazarevic V, Jones DC, Lanser AJ, Takagi T, Ishii S, Glimcher LH
- Journal Title
  
  Nature
  
  Volume: 472 Issue: 7341 Pages: 105-109
- DOI
  10.1038/nature09848
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22125005, KAKENHI-PROJECT-22590443, KAKENHI-PROJECT-23370079, KAKENHI-PROJECT-23659244
[Journal Article] Schnurri-2 mutant mice are hypersensitive to stress and hyperactive.2006
- Author(s)
  Takagi, T. et al.
- Journal Title
  
  Brain Res. 1108
  
  Pages: 88-97
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14002011
[Presentation] 知的障害MRD43に対する社会的な環境要因の影響2024
- Author(s)
  高木豪　浅井真人
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-22K07952
[Presentation] 知的障害MRD43モデルマウスにおける社会的ストレスの影響2023
- Author(s)
  高木豪　浅井真人
- Organizer
  第70回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-22K07952
[Presentation] 優性遺伝型のモデルマウス産出への精子de novo変異導入法の利用2022
- Author(s)
  高木　豪, 浅井真人
- Organizer
  第69回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-22K07952
[Presentation] 優性遺伝型のモデルマウス産出への精子de novo変異導入法の利用2022
- Author(s)
  高木豪, 浅井真人
- Organizer
  第69回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-19K06684
[Presentation] 精子de novo変異導入法による優性遺伝疾患モデルマウスの作製2021
- Author(s)
  高木豪、浅井真人
- Organizer
  日本臨床分子形態学会
- Data Source
  KAKENHI-PROJECT-19K06684
[Presentation] 重度知的障害を伴うRubinstein-Taybi syndromeのde novo変異型モデルマウスを用いた解析2019
- Author(s)
  高木豪
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19K06684
[Presentation] 重度知的障害を伴うRubinstein-Taybi syndromeのde novo変異型モデルマウスを用いた解析2019
- Author(s)
  高木豪、浅井真人、石井俊輔
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-16K09980
[Presentation] De novo変異型Rubinstein-Taybi syndromeモデルマウスの行動学的解析2018
- Author(s)
  高木豪、浅井真人、石井俊輔
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-16K09980
[Presentation] De novo変異型Rubinstein-Taybi Syndromeモデルマウスの作製2017
- Author(s)
  Tsuyoshi Takagi
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-16K09980
[Presentation] de novo型Sip1ヘテロ変異マウスを用いたMowat-Wilson syndromeのモデル動物としての有用性の検討2013
- Author(s)
  高木豪, 東雄二郎
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Year and Date
  2013-12-11
- Data Source
  KAKENHI-PROJECT-22590443
[Presentation] Chip on chip analysis of transcription factor, Schnurri-2 using DP cells.2010
- Author(s)
  高木豪、石井俊輔
- Organizer
  日本分子生物学会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-22590443
[Presentation] Positive selectionに必要なSchnurr-2のchip on chip法を用いた解析2010
- Author(s)
  高木豪, 石井俊輔
- Organizer
  第33回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2010-12-14
- Data Source
  KAKENHI-PROJECT-22590443
[Presentation] de novo型Sip1ヘテロ変異マウスを用いたMowat-Wilson syndromeのモデル動物としての有用性の検討
- Author(s)
  高木豪
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  マリンメッセ福岡（福岡）
- Data Source
  KAKENHI-PROJECT-22590443

1. ISHII Shunsuke (00124785)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. SHIMADA Nobukazu (80391978)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. ISHIDAO Takefumi (20391857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 品川敏恵 (70344041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 古倉健嗣 (30344039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 田中康範 (80311348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 田中基樹 (90584673)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KITAURA Hiroki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 柿田明美

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# of Collaborated Products: 1 results
10. 岩里琢治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takagi Tsuyoshi 高木 豪

高木 豪 タカギ ツヨシ

TAKAGI Tsuyoshi 高木 豪

Research Projects

Research Products

Co-Researchers

Effect of environmental stress on intellectual disability MRD43Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The analysis of cortical interneuron formation in mouse embryoPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of Mowat-Wilson syndrome using model mousePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of positive selection process during T eell development via large transcription factorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Transcriptional control by mediators and their physiological significance

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

マウスschnurri遺伝子ファミリーの胸腺T細胞の分化における機能の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Girdin deficiency causes developmental and epileptic encephalopathy with hippocampal sclerosis and interneuronopathy.2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Using of de novo mutation system for study obtaining dominant type model animal2022

Author(s)

Journal Title

Data Source

[Journal Article] Using of de novo mutation system for study obtaining dominant type model animal2022

Author(s)

Journal Title

Data Source

[Journal Article] Introduction of a de novo Creb-binding protein gene mutation in sperm to produce a Rubinstein-Taybi syndrome model using inbred C57BL/6 mice2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Attenuated bidirectional short-term synaptic plasticity in the dentate gyrus of Schnurri-2 knockout mice, a model of schizophrenia2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Deficiency of Schnurri-2, a MHC enhancer binding protein, induce mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizopherenia2013

Author(s)

Journal Title

Data Source

[Journal Article] Dampening of death pathways by schnurri-2 is essential for T-cell development2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Schnurri-2 mutant mice are hypersensitive to stress and hyperactive.2006

Takagi Tsuyoshi 高木豪

高木豪タカギツヨシ

TAKAGI Tsuyoshi 高木豪