SAITO TARO 斎藤太郎

… Alternative Names

斎藤太郎サイトウタロウ

SAITO Taro 斎藤太郎

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Researcher Number	70301413
Other IDs
External Links
Affiliation (Current)	2025: 東京都立大学, 理学研究科, 助教
Affiliation (based on the past Project Information) *help	2015: 首都大学東京, 大学院理工学研究科, 助教 2007 – 2008: Tokyo Metropolitan University, 大学院・理工学研究科, 助教 2007 – 2008: Tokyo Metropolitan University, Graduate School of Secience and Engineering, Assistant Professor 2006: 首都大学東京, 大学院理工学研究科, 助手 2005: 首都大学東京, 都市教養学部, 助手 1999 – 2004: 東京都立大学, 理学研究科, 助手 2000: 東京都立大学, 大学院・理学研究科, 助手
Review Section/Research Field	Principal Investigator Neurochemistry/Neuropharmacology / Biological Sciences / Neurochemistry/Neuropharmacology Except Principal Investigator Biological Sciences / Cell biology / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology
Keywords	Principal Investigator Cdk5 / プロテインキナーゼ / 小胞体ストレス / 神経細胞死 / サイクリン依存性キナーゼ / ハンチントン病 / 神経変性疾患 / プロテインホスファターゼ / シナプス可塑性 / Cdk … More / カルパイン / リン酸化 / プロテアソーム / p35 / CDK5 … More Except Principal Investigator Cdk5 / カルパイン / リン酸化 / 神経細胞 / プロテアソーム / p35 / アルツハイマー病 / CDK5 / Neuron / 酵素 / 神経細胞死 / プロテインキナーゼ / シグナル伝達 / 神経 / タンパク質 / Proteasome / Alzheimer / Protein kinase / Calpain / タンパク分解 / タウ / カルシウム / 蛋白分解 / 老化 / Grab / GRAB / Rab / LMTK1 / 発生・分化 / 神経科学 / Sienal transduction / Calo ain / Phosohorvlation / 細胞膜 / 蛋白質 / アルツハイマー / 細包膜 / 分解 / 脳・神経 / Siganal transduction / Phosphorylation / 記憶 / NMDA / シナプ / グルタミン酸受容体 / 長期増強 / Neuronal cell death / phosphorylation / proteasome / 脳 / 膜結合 / ミリストイル化 / プロテアーゼ / 微小管 / FTDP-17 / FTDP17 / p25 / 加齢 / reelin / 脳形成 / 細胞死 / サイクリン Less

Physiology and pathology of endocytosis and recycling transport in neurons
- Principal Investigator
  
  Hisanaga Shin-ichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tokyo Metropolitan University
プロテアソームとカルパインのクロストークと神経機能制御に関する研究
- Principal Investigator
  
  久永眞市
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan University
Analysis of neuronal death-promoting mechanism of Cdk5/p25Principal Investigator
- Principal Investigator
  
  SAITO Taro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tokyo Metropolitan University
Cdk5/p35のシナプス活動抑制作用についての解析Principal Investigator
- Principal Investigator
  
  斎藤太郎
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan University
Regulation of Cdk5 activity and function in neurons
- Principal Investigator
  
  HISANAGA Shin-ichi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tokyo Metropolitan University
アルツハイマー病神経細胞死におけるp25/Cdk5の役割
- Principal Investigator
  
  久永眞市
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan University
アルツハイマー病神経細胞死におけるp25/Cdk5の役割
- Principal Investigator
  
  久永眞市
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan University
神経細胞死におけるCdk5活性化サブユニットp35の限定分解Principal Investigator
- Principal Investigator
  
  斎藤太郎
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tokyo Metropolitan University
アルツハイマー病における神経細胞死とCDK5活性化サブユニットp35の限定分解
- Principal Investigator
  
  久永真市
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan University
The novel function of cyclin-dependent kinase 5, a role in long term potentiation
- Principal Investigator
  
  HISANAGA Shin-ichi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Tokyo Metropolitan University
アルツハイマー病における神経細胞死とCDK5活性化サブユニットp35の限定分解
- Principal Investigator
  
  久永真市
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan University
CDK5結合性新規細胞質型チロシンキナーゼの脳形成における役割
- Principal Investigator
  
  久永真市
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan University
神経細胞におけるCDK5活性化サブユニットp35のプロテアソームによる分解機構Principal Investigator
- Principal Investigator
  
  斎藤太郎
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tokyo Metropolitan University
The regulation mechanism of degradation of p35 CDK5 activation subunit in neurons
- Principal Investigator
  
  HISANAGA Shin-ichi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Tokyo Metropolitan University
神経細胞におけるCDK5活性化サブユニットp35の選択的分解機構の解析
- Principal Investigator
  
  HISANAGA Shin-ichi
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tokyo Metropolitan University

All 2013 2008 2007 2005

All Journal Article Presentation Book

[Book] 神経細胞におけるCDK5の機能とその異常活性化による神経変性疾患.2013
- Author(s)
  斎藤太郎、久永眞市
- Total Pages
  6
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-25290024
[Journal Article] Structural basis for the different stability and activity between the Cdk5 complexes with p35 and p39 activators.2013
- Author(s)
  Saito et al.,
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 288 Issue: 45 Pages: 32433-32439
- DOI
  10.1074/jbc.m113.512293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290024
[Journal Article] Suppression of mutant Huntingtin aggregate formation by Cdk5/p35 through the effect on microtubule stability.2008
- Author(s)
  Kaminosono*, S., Saito*, T., Oyama, F., Ohshima, T., Asada, A., Nagai, Y., Nukina, N. and Hisanaga, S.
- Journal Title
  
  J Neurosci 28
  
  Pages: 8747-8755
- Data Source
  KAKENHI-PROJECT-19700344
[Journal Article] Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cvcline-dependent kinase 5 complexes.2008
- Author(s)
  Asada, A., Yamamoto, N., Gohda, M., Saito. T, Hayashi, N. and Hisanaga, S.
- Journal Title
  
  Journal of Neurochemistry 106
  
  Pages: 1325-1336
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700344
[Journal Article] Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cycline-dependent kinase 5 complexes.2008
- Author(s)
  Asada, A., Yamamoto, N., Gohda, M., Saito, T., Hayashi, N. and Hisanaga, S.
- Journal Title
  
  J Neurochem 106
  
  Pages: 1325-1336
- Data Source
  KAKENHI-PROJECT-19700344
[Journal Article] Suppression of mutant Huntingtin aggregate formation by Cdk5/p 35 through the effect on microtubule stability.2008
- Author(s)
  Kaminosono*, S., Saito*. T, Oyama, F., Ohshima, T., Asada, A., Nagai, Y., Nukina, N. and Hisanaga, S.. (*equal contribution)
- Journal Title
  
  Journal of Neuroscience 28
  
  Pages: 8747-8755
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700344
[Journal Article] Casein kinase 2 is the major enzyme in brain that phosthorylates Ser129 of human alpha-synuclein:lmplication for alpha-synuc leinopathies2007
- Author(s)
  Ishii, A., Nonaka, T., Taniguchi, S., Saito, T., Arai, T., Mann, D., Iwatsubo, T., Hisanaga, SI., Goedert, M. And Hasegawa, M.
- Journal Title
  
  FEBS Lettes 581
  
  Pages: 4711-4717
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700344
[Journal Article] Regulation of membrane association and kinase activity of Cdk5-p35 by phosphorylation of p352007
- Author(s)
  Sato, K., Zhu, YS., Saito, T., Yotsumoto, K., Asada, A., Hasegawa, M, and Hisanaga, S.
- Journal Title
  
  Journal of Neuroscience Research 85
  
  Pages: 3071-3078
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700344
[Journal Article] p25/cyclin-dependent kinase 5 promotes the progression of cell death in nucleus of endoplasmic reticulum-stressed neurons.2007
- Author(s)
  Saito, T., Konno, T., Hosokawa, T., Asada, A., Ishiguro, K. and Hisanaga, S.
- Journal Title
  
  J Neurochem 102
  
  Pages: 133-140
- Data Source
  KAKENHI-PROJECT-19700344
[Journal Article] Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25by site-specific phosphorylation.2007
- Author(s)
  Kamei, H., Saito, T., Ozawa, M., Fujita, Y., Asada, A., Bibb, J. A., Saido, T. C., Sorimachi, H. and Hisanaga, S.
- Journal Title
  
  Biol Chem 282
  
  Pages: 1687-1694
- Data Source
  KAKENHI-PROJECT-19700344
[Journal Article] Phosphorylation of adult type Sept5(CDCrel-1)by cyclin-depend ent kinase 5 inhibits interaction with symtaxin-12007
- Author(s)
  Taniguchi, M., Taoka, M., Itakura, M., Asada, A., Saito, T., Kinoshita, M., Takahashi, M., Isobe, T. and Hisanaga, S.
- Journal Title
  
  Journal of Biologial Chemistry 282
  
  Pages: 7869-7876
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700344
[Journal Article] Cdk5-p35 is a labile complex with the similar substrate specificity to Cdk5-p352007
- Author(s)
  Yamada, M., Saito, T., Sato, Y., Kawai, Y., Sekigawa, A., Hamazumi, Y., Asada, A., Wada, M., Doi, H. and Hisanaga S.
- Journal Title
  
  Journal of Neurochemistry 102
  
  Pages: 1477-1478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700344
[Journal Article] Regulation of the interaction of Disabled-1 with CIN85 by phosphorylation with Cyclin-dependent kinase 5.2007
- Author(s)
  Sato, Y., Taoka, M., Sugiyama, N., Kubo, K., Fuchigami, T., Asada, A., Saito, T., Nakajima, K., Isobe, T. and Hisanaga, S.
- Journal Title
  
  Genes Cells 12
  
  Pages: 1315-1327
- Data Source
  KAKENHI-PROJECT-19700344
[Journal Article] p25/cyclin-dependent kinase 5 pronmotes the progression of cell death in nucleus of endoplasmic reticulum-stressed neurons2007
- Author(s)
  Saito, T., Konno, T., Hosokawa, T., Asads, A., Ishiguro, K. and Hisanaga, S.
- Journal Title
  
  Journal of Neurochemistry 102
  
  Pages: 133-140
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700344
[Journal Article] Phosphorylation of adult type Sept5 (CDCrel-1) by cyclin-dependent kinase 5 inhibits interaction with syntaxin-1.2007
- Author(s)
  Taniguchi, M., Taoka, M., Itakura, M., Asada, A., Saito, T., Kinoshita, M., Takahashi, M., Isobe, T. and Hisanaga, S.
- Journal Title
  
  J Biol Chem 282
  
  Pages: 7869-7876
- Data Source
  KAKENHI-PROJECT-19700344
[Journal Article] Regulation of the interaction of Disabled-1 with CLN85 by phosp horylation with Cyclin-dependent kinase 52007
- Author(s)
  Sato, Y., Taoka, M., Sugiyama, N., Kubo, K., Fuchigsmi, T., Asada, A., Saito, T., Nakajima, K., Isobe, T. and Hisanaga, S.
- Journal Title
  
  Gense to Cells 12
  
  Pages: 1315-1327
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700344
[Journal Article] Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation2007
- Author(s)
  Kamei, H., Saito, T., Ozawa, M., Fujita, Y., Asada, A., Bibb, J.A., Saido, T.C., Sorimachi, H. and Hisanaga, S.
- Journal Title
  
  Journal of Biologial Chemistry 282
  
  Pages: 1687-1694
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700344
[Journal Article] Regulation of membrane association and kinase activity of Cdk5-p35 by phosphorylation of p35.2007
- Author(s)
  Sato, K., Zhu, YS., Saito, T., Yotsumoto, K., Asada, A., Hasegawa, M. and Hisanaga, S.
- Journal Title
  
  Neurosci Res 85
  
  Pages: 3071-3078
- Data Source
  KAKENHI-PROJECT-19700344
[Journal Article] Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha-synucleinopathies.2007
- Author(s)
  Ishii, A., Nonaka, T., Taniguchi, S., Saito, T., Arai, T., Mann, D., Iwatsubo, T., Hisanaga, SI., Goedert, M. and Hasegawa, M.
- Journal Title
  
  FEBS Lett 581
  
  Pages: 4711-4717
- Data Source
  KAKENHI-PROJECT-19700344
[Journal Article] Cdk5-p39 is a labile complex with the similar substrate specificity to Cdk5-p35.2007
- Author(s)
  Yamada, M., Saito, T., Sato, Y., Kawai, Y., Sekigawa, A., Hamazumi, Y., Asada, A., Wada, M., Doi, H. and Hisanaga S.
- Journal Title
  
  J Neurochem 102
  
  Pages: 1477-1487
- Data Source
  KAKENHI-PROJECT-19700344
[Journal Article] Phosphorylation of FTDP-17 mutant TAU by cyclin-dependent kinase 5 complexed with p35, p25, or p392005
- Author(s)
  Sakaue F, Saito T, 他5名
- Journal Title
  
  Journal of Biological Chemistry 280
  
  Pages: 31522-31529
- Data Source
  KAKENHI-PROJECT-17024050
[Journal Article] Activation of latent cyclin-dependent kinase 5 (CdkS)-p35 complexes by membrane dissociation2005
- Author(s)
  Zhu YS, Saito T, 他3名
- Journal Title
  
  Journal of Neurochemistry 94
  
  Pages: 1535-1545
- Data Source
  KAKENHI-PROJECT-17024050
[Presentation] 後シナプス領域におけるCdk5とCaMKIIの相互作用2008
- Author(s)
  細川智永、斎藤太郎、浅田明子、久永眞市
- Organizer
  第51回日本神経化学会大会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-19700344
[Presentation] サイクリン依存性キナーゼ5の活性制御と神経変性疾患2008
- Author(s)
  久永眞市、淺田明子、斎藤太郎
- Organizer
  第31回日本分子生物学会シンポジウム
- Place of Presentation
  神戸
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-19044036
[Presentation] Crosstalk between Cdk5 and CaMKII in the postsynaptic region.2007
- Author(s)
  Hosokawa, T., Saito, T., Asada, A., Hisanaga, S.
- Organizer
  第37回北米神経科学会
- Place of Presentation
  サンディエゴ
- Data Source
  KAKENHI-PROJECT-19700344
[Presentation] Inhibition of mutant huntingtin aggregate formation by Cdk5/p35.2007
- Author(s)
  Kaminosono, S., Saito, T., Oyama, F., Asada, A., Nukina, N., Hisanaga, S.
- Organizer
  第37回北米神経科学会
- Place of Presentation
  サンディエゴ
- Data Source
  KAKENHI-PROJECT-19700344
[Presentation] パーキンソン病モデル神経細胞におけるCdk5活性化サブユニットp35の分解制御と細胞死2007
- Author(s)
  遠藤良、斎藤太郎、浅田明子、久永眞市
- Organizer
  病態と治療におけるプロテアーゼとインヒビター学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19700344
[Presentation] MPP+又は6-OHDAによるCdk5/p35の分解制御と細胞死2007
- Author(s)
  遠藤良、斎藤太郎、浅田明子、久永眞市
- Organizer
  第50回日本神経化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19700344
[Presentation] Dephosphorylation of Cdk5-phosphorylated FTDP-17 mutant tau.2007
- Author(s)
  Yotsumoto, K., Sakaue, F., Oikawa, T., Ishiguro, K., Saito, T., Asada, A., Hasegawa, M., Hisanaga, S.
- Organizer
  認知症学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19700344
[Presentation] Cdk5活性化サブユニットp35とp39は膜上で選択的に分解されている2007
- Author(s)
  嶺岸正治、浅田明子、渕上孝裕、宮内伸也、斎藤太郎、久永眞市
- Organizer
  第30回分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19700344
[Presentation] Regulation of the membrane association and kinase activity of Cdk5-p35 by phosphorylation of p35.2007
- Author(s)
  Sato, K., Zhu, Y-S., Saito, T., Yotsumoto, K., Asada, A., Hasegawa, M., Hisanaga, S.
- Organizer
  第50回日本神経化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19700344
[Presentation] Proteolysis of Cdk5 activators p35 and p39 on membranes.2007
- Author(s)
  Minegishi, S., Asada, A., Miyauchi, S., Fuchigami, T., Saito, T., Ishiguro, K., Hisanaga, S.
- Organizer
  第37回北米神経科学会
- Place of Presentation
  サンディエゴ
- Data Source
  KAKENHI-PROJECT-19700344
[Presentation] p25/cyclin-dependent kinase 5 promotes the rpogression of cell death in nucleus of endoplasmic r eticulum-stressed neurons2007
- Author(s)
  Taro Saito, Tsunetada Konno, Tomohisa Hosokawa, Akiko Asada, Koichilshiguro and Shin-ichi Hisanaga
- Organizer
  第37回北米神経科学会
- Place of Presentation
  サンディエゴ
- Data Source
  KAKENHI-PROJECT-19700344
[Presentation] 神経細胞死におけるp25/Cdk5の核移行2007
- Author(s)
  斎藤太郎、遠藤良、浅田明子、久永真市
- Organizer
  第50回日本神経化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19700344
[Presentation] Deregulation of p35 Cdk5 activator metabolisms in MPP+-induced neuronal cell death.2007
- Author(s)
  Endo, R., Saito, T., Asada, A., Hisanaga, S.
- Organizer
  第37回北米神経科学会
- Place of Presentation
  サンディエゴ
- Data Source
  KAKENHI-PROJECT-19700344
[Presentation] Regulation of the interaction of Dab1 with CIN85 by phosphorylation with Cyclin-dependent kinase 5.2007
- Author(s)
  Sato, Y., Taoka, M., Sugiyama, N., Kubo, K., Fuchigami, T., Asada, A., Saito, T., Nakajima, K., Isobe, T., Hisanaga, S.
- Organizer
  細胞生物学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19700344
[Presentation] p25/cyclin-dependent kinase 5 promotes the progression of cell death in nucleus of endoplasmic reticulum-stressed neurons.2007
- Author(s)
  Saito, T., Konno, T., Hosokawa, T., Asada, A., Ishiguro, K., Hisanaga, S.
- Organizer
  第37回北米神経科学会
- Place of Presentation
  サンディエゴ
- Data Source
  KAKENHI-PROJECT-19700344
[Presentation] 膜結合に依存したCdk5活性化サブユニットp35とp39の分解制御機構の解析2007
- Author(s)
  嶺岸正治、浅田明子、宮内伸也、渕上孝裕、斎藤太郎、久永眞市
- Organizer
  病態と治療におけるプロテアーゼとインヒビター学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19700344

1. HISANAGA Shin-ichi (20181092)

# of Collaborated Projects: 11 results

# of Collaborated Products: 2 results
2. ASADA Akiko (00336512)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results

SAITO TARO 斎藤 太郎

斎藤 太郎 サイトウ タロウ

SAITO Taro 斎藤 太郎

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Analysis of neuronal death-promoting mechanism of Cdk5/p25Principal Investigator

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Cdk5/p35のシナプス活動抑制作用についての解析Principal Investigator

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神経細胞死におけるCdk5活性化サブユニットp35の限定分解Principal Investigator

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神経細胞におけるCDK5活性化サブユニットp35のプロテアソームによる分解機構Principal Investigator

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SAITO TARO 斎藤太郎

斎藤太郎サイトウタロウ

SAITO Taro 斎藤太郎