Sugama Shuei 洲鎌秀永

… Alternative Names

洲鎌秀永スガマシユウエイ

SUGAMA Syuei 洲鎌秀永

洲鎌秀英スガマシユウエイ

SUGAMA Shuei 洲鎌秀永

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Researcher Number	70302461
Other IDs
Affiliation (Current)	2025: 国際医療福祉大学, 基礎医学研究センター, 教授
Affiliation (based on the past Project Information) *help	2024: 国際医療福祉大学, 基礎医学研究センター, 教授 2021 – 2022: 日本医科大学, 医学部, 准教授 2008 – 2017: Nippon Medical School, 医学部, 講師 2005 – 2006: 日本医科大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Neurochemistry/Neuropharmacology / Neuroscience in general / Neurophysiology and muscle physiology / Neurophysiology and muscle physiology Except Principal Investigator Basic Section 52030:Psychiatry-related / Basic Section 59040:Nutrition science and health science-related
Keywords	Principal Investigator ストレス / ノルアドレナリン / 視床下部 / ミクログリア / 酸化ストレス / ドーパミン / 黒質 / 慢性ストレス / 青斑核 / 中枢神経 … More / 交感神経系 / 海馬 / 鬱病 / 腹側被蓋野 / パーキンソン病 / Inflammation / Neurodegenerative disease / Central Nervous System / Interleukin-18 / Microglia / Stress / 副腎 / IL-18 / 退行性神経変化 / 炎症反応 / 退行性神経疾患 / インターロイキン18 / マイクログリア / 脳内炎症 / 副腎ステロイド / 神経科学 / 神経免疫 / ニトロタイロシン / 脳内免疫 / アドレナリン受容体 / グルタミン酸 / Fos蛋白 / 中心灰白質 / 感染 / インターロイキン1 / サイトカイン / アストログリア / インターロイキン1β / 寒冷刺激 / アストロサイト / RT-PCR / ダブルノックアウトマウス / イソプロテレノロール / LPS / 副腎皮質ステロイド / ノルアドレナリン受容体 / 拘束ストレス / 神経免疫学 / グリア … More Except Principal Investigator D-セリン / 精神疾患 / 硫酸化 / グリア / プロテオグリカン / コリン作動系 / 鰹節抽出物 / 血液脳関門 / 鰹節熱抽出物 / 抗炎症 Less

Elucidation of the pathophysiology of psychiatric disorders aiming for new treatments acting on the proteoglycan sulfation mechanism
- Principal Investigator
  
  上里彰仁
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  International University of Health and Welfare
コリン作動系修飾物を介した血液脳関門強化と抗炎症作用による認知機能介入の可能性
- Principal Investigator
  
  柿沼由彦
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Nippon Medical School
Investigation of microglia and chronic stress in the onset of Parkinson diseasePrincipal Investigator
- Principal Investigator
  
  Sugama Shuei
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Nippon Medical School
Investigation of microglial activation through noradrenaline in the process of neurodegenerative diseasePrincipal Investigator
- Principal Investigator
  
  SUGAMA Shuei
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Nippon Medical School
Investigation of stress-induced microglial activationPrincipal Investigator
- Principal Investigator
  
  SUGAMA Shuei (SUGAMA Syuei)
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Nippon Medical School
Does stress promotes neurodegenerative changes?Principal Investigator
- Principal Investigator
  
  SUGAMA Shuei
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neuroscience in general
- Research Institution
  Nippon Medical School

[Journal Article] Katsuo extract derived from dried bonito plays a role in systemic anti-inflammation and consolidation of the blood-brain barrier to regulate higher brain functions2022
- Author(s)
  Hokari Y, Sekine A, Kai Y, Oikawa S, Mano A, Ohata H, Sugama S, Kakinuma Y
- Journal Title
  
  Frontiers in Natural Products
  
  Volume: 1 Pages: 1-13
- DOI
  10.3389/fntpr.2022.969433
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K11658
[Journal Article] Evolvability of amyloidogenic proteins in human brain2018
- Author(s)
  Hashimoto M, Ho G, Sugama S, Takamatsu Y, Shimizu Y, Takenouchi T, Waragai M, Masliah E
- Journal Title
  
  J Alzheimers Dis
  
  Volume: 62 Issue: 1 Pages: 73-83
- DOI
  10.3233/jad-170894
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06783
[Journal Article] Potential application of centrifuges to protect the CNS in space and on earth2018
- Author(s)
  Hashimoto M, Ho G, Shimizu Y, Sugama S, Takenouchi T, Waragai M, Wei J, Takamatsu Y
- Journal Title
  
  Curr Alzheimer Res
  
  Volume: 15 Issue: 6 Pages: 544-551
- DOI
  10.2174/1567205015666171229225501
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06783
[Journal Article] Importance of adiponectin activity in the pathogenesis of Alzheimer's disease2017
- Author(s)
  Waragai M, Ho G, Takamatsu Y, Sekiyama K, Sugama S, Takenouchi T, Masliah E, Hashimoto M
- Journal Title
  
  Ann Clin Transl Neurol
  
  Volume: 4 Issue: 8 Pages: 591-600
- DOI
  10.1002/acn3.436
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06783, KAKENHI-PROJECT-15K09820
[Journal Article] Lack of interleukin-13 receptor a1 delays the loss of dopaminergic neurons during chronic stress2017
- Author(s)
  Mori S, Sugama S, Nguyen W, Michel T, Sanna MG, Sanchez-Alavez M, Cintron-Colon R, Moroncini G, Kakinuma Y, Maher P, Conti B
- Journal Title
  
  J Neuroinflammation
  
  Volume: 14 Pages: 88-88
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06783
[Journal Article] Letter to the Editor Re:"Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend of foe?" by Ong et al. Brain Behavior and Immunity, 2016.2017
- Author(s)
  Sugama S, Kakinuma Y
- Journal Title
  
  Brain Behav Immun
  
  Volume: 60 Pages: 383-383
- DOI
  10.1016/j.bbi.2016.11.028
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K06783, KAKENHI-PROJECT-16K08560
[Journal Article] Loss of dopaminergic neurons occurs in the ventral tegmental area and hypothalamus of rats following chronic stress: Possible pathogenetic loci for depression involved in Parkinson's disease2016
- Author(s)
  Sugama S, Kakinuma Y
- Journal Title
  
  Neurosci Res
  
  Volume: 111 Pages: 48-55
- DOI
  10.1016/j.neures.2016.04.008
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K06783, KAKENHI-PROJECT-16K08560
[Journal Article] Combined immunotherapy with “anti-insulin resistance” therapy as a novel therapeutic strategy against neurodegenerative diseases.2016
- Author(s)
  Takamatsu Y, Ho G, Koike W, Sugama S, Takenouchi T, Waragai M, Wei J, Sekiyama K, Hashimoto M.
- Journal Title
  
  npj Parkinson’s Disease
  
  Volume: 3 Issue: 1 Pages: 4-4
- DOI
  10.1038/s41531-016-0001-1
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25290019, KAKENHI-PROJECT-26640033, KAKENHI-PROJECT-15K06783
[Journal Article] Non-neuronal cardiac cholinergic system influences CNS via the vagus nerve to acquire a stress-refractory propensity.2016
- Author(s)
  Oikawa S, Kai Y, Tsuda M, Ohata H, Mano A, Mizoguchi N, Sugama S, Nemoto T, Suzuki K, Kurabayashi A, Muramoto K, Kaneda M, and Kakinuma Y.
- Journal Title
  
  Clinical Science
  
  Volume: 130(21) Issue: 21 Pages: 1913-1928
- DOI
  10.1042/cs20160277
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26463192, KAKENHI-PROJECT-15K06783, KAKENHI-PROJECT-16K08560, KAKENHI-PROJECT-15K15043
[Journal Article] Chronic restraint stress triggers dopaminergic and noradrenergic neurodegeneration: Possible role of chronic stress in the onset of Parkinson's disease2016
- Author(s)
  Sugama S, Sekiyama K, Kodama T, Takamatsu Y, Takenouchi T, Hashimoto M, Conti B, Kakinuma Y
- Journal Title
  
  Brain Behav Immun
  
  Volume: 51 Pages: 39-46
- DOI
  10.1016/j.bbi.2015.08.015
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06783, KAKENHI-PROJECT-26640033, KAKENHI-PROJECT-25460333, KAKENHI-PROJECT-25290019, KAKENHI-PROJECT-16K08560
[Journal Article] Extracellular ATP induces unconventional release of glyceraldehyde-3-phosphate dehydrogenase from microglial cells2015
- Author(s)
  Takenouchi T, Tsukimoto M, Iwamaru Y, Sugama S, Sekiyama K, Sato M, Kojima S, Hashimoto M, Kitani H
- Journal Title
  
  Immunol Lett
  
  Volume: 167 Issue: 2 Pages: 116-124
- DOI
  10.1016/j.imlet.2015.08.002
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06783, KAKENHI-PROJECT-25450521
[Journal Article] Disease-Modifying Effect of Adiponectin in Model of a-Synucleinopathies2014
- Author(s)
  Sekiyama K, Waragai M, Akatsu H, Sugama S, Takenouchi T, Takamatsu Y, Fujita M, Sekigawa A, Rockenstein E, Inoue S, La Spada AR, Masliah E, Hashimoto M
- Journal Title
  
  Ann Clin Transl Neurol
  
  Volume: 1 Pages: 479-489
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24500465
[Journal Article] Corticosteroids limit microglial activation occurring during acute stress2012
- Author(s)
  Sugama S, Takenouchi T, Fujita M, Kitani H, Conti B, Hashimoto M
- Journal Title
  
  Neuroscience
  
  Volume: 232 Pages: 13-20
- DOI
  10.1016/j.neuroscience.2012.12.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500465
[Journal Article] Theaflavins stimulate autophagic degradation of a-synuclein in neuronal cells2012
- Author(s)
  T, Waragai M, Wei J, Sekigawa A, Takamatsu Y, Sugama S, Kitani H, Hashimoto M
- Journal Title
  
  Open Journal of Neuroscience
  
  Volume: 2-1
- URL
  http://www.rossscience.org/ojns/articles/2075-9088-2-1.pdf
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] Ibuprofen ameliorates protein aggregation and astrocytic gliosis, but not cognitive dysfunction, in a transgenic mouse expressing dementia with Lewy bodies-linked P123H b-synuclein2012
- Author(s)
  S ekiyama K, Fujita M, Sekigawa A, Takamatsu Y, Waragai M, Takenouchi T, Sugama S, Hashimoto M
- Journal Title
  
  Neurosci Lett
  
  Volume: 515(1) Issue: 1 Pages: 97-101
- DOI
  10.1016/j.neulet.2012.03.037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500359, KAKENHI-PROJECT-21700399, KAKENHI-PROJECT-24500465, KAKENHI-PUBLICLY-24111555
[Journal Article] Cytochalasin D enhances the accumulation of a protease-resistant form of prion protein in ScN2a Cells: Involvement of PI3 kinase/Akt signaling pathway.2012
- Author(s)
  Takenouchi T. et al.
- Journal Title
  
  Cell Biol. Int.
  
  Volume: 36 Issue: 12 Pages: 1223-1231
- DOI
  10.1042/cbi20120329
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390040, KAKENHI-PROJECT-22580389, KAKENHI-PROJECT-24500465, KAKENHI-PLANNED-22113009
[Journal Article] IL-13Ra1 expression in dopaminergic neurons contributes to thier oxidative stress-mediated loss following chronic peripheral treatment with lipopolysaccharide2012
- Author(s)
  Morrison BE, Marcondes MC, Nomura DK, Sanchez-Alavez M, Sanchez-Gonzalez A, Saar I, Kim KS, Bartfai T, Maher P, Sugama S, Conti B
- Journal Title
  
  J Immunol
  
  Volume: 15 Issue: 12 Pages: 5498-5502
- DOI
  10.4049/jimmunol.1102150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500465
[Journal Article] Immunological responses of astroglia in the rat brain under acute stress : interletikin-1 beta co-localized in astroglia2011
- Author(s)
  Sugama S, Takenouchi T, Sekiyama K, Kitani H, Hashimoto M
- Journal Title
  
  Neuroscience
  
  Volume: 192 Pages: 429-437
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] The activation of P2X7 receptor induces cathepsin D-dependent production of a 20-kDa form of IL-1b under acidic extracellular pH in LPS-primed microglial cells2011
- Author(s)
  Takenouchi T, Iwamaru Y, Sugama S, Tsukimoto M, Fujita M, Sekigawa A, Sekiyama K, Sato M, Kojima S, Conti B, Hashimoto M, Kitani H
- Journal Title
  
  Journal of Neurchemistry
  
  Volume: 117 Pages: 712-723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] The activation of P2X7 receptor induces cathepsin D-dependent production of a 20-kDa form of IL-1b under acidic extracellular pH in LPS-primed microglial cells2011
- Author(s)
  T akenouchi T, Iwamaru Y, Sugama S, Tsukimoto M, Fujita M, Sekigawa A, Sekiyama K, Sato M, Kojima S, Conti B, Hashimoto M, Kitani H
- Journal Title
  
  J. Neurochem
  
  Volume: 117 Pages: 712-723
- DOI
  10.1111/j.1471-4159.2011.07240.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500359, KAKENHI-PROJECT-21700399, KAKENHI-PROJECT-22580389
[Journal Article] Cold stress induced morphological microglial activation and increased IL-1b expression in astroglial cells in rat brain2011
- Author(s)
  Sugama S, Takenouchi T, fujita M, Kitani H, Hashimoto M
- Journal Title
  
  Journal of Neuroimmunology
  
  Volume: 233 Pages: 29-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] Cold stress induced morphological microglial activation and increased IL-1βexpression in astroglial cells in rat brain2011
- Author(s)
  Sugama S, Takenouchi T, Fujita M, Kitani H, Hashimoto M
- Journal Title
  
  J. Neuroimmunol
  
  Volume: 233 Issue: 1-2 Pages: 29-36
- DOI
  10.1016/j.jneuroim.2010.11.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500359, KAKENHI-PROJECT-21700399
[Journal Article] Immunological responses of astroglia in the rat brain under acute stress : interleukin-1 beta co-localized in astroglia2011
- Author(s)
  Sugama S, Takenouchi T, Sekiyama K, Kitani H, Hashimoto M
- Journal Title
  
  Neuroscience
  
  Volume: 192 Pages: 429-437
- DOI
  10.1016/j.neuroscience.2011.06.051
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] P2X7 receptor signaling pathway as a therapeutic target for neurodegenerative diseases2010
- Author(s)
  Takenouchi T, Sekiyama K, Sekigawa A, Fujita M, Waragai M, Sugama S, Iwamaru Y, Kitani H, Hashimot M
- Journal Title
  
  Arch Immunol Ther Exp (Warsz) 58
  
  Pages: 91-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] P2X7 receptor signaling pathway as a therapeutic target for neurodegenerative diseases.2010
- Author(s)
  Takenouchi T, Sekiyama K, Sekigawa A, Fujita M, Waragai M, Sugama S, Iwamaru Y, Kitani H, Hashimot M.
- Journal Title
  
  Arch Immunol Ther Exp (Warsz). 58
  
  Pages: 91-96
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] P2X7 receptors signaling pathway as a therapeutic target for neurodege nerative diseases.2010
- Author(s)
  Takenouchi T, Sekiyama K, Sekigawa A, Fujita M, Waragai M, Sugama S, et al.
- Journal Title
  
  Arch Immunol Ther Exp (Warsz)
  
  Volume: 58 Pages: 91-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] Interleukin-18 in the CNS2010
- Author(s)
  Alboni S, Cervia D, Sugama S, Conti B
- Journal Title
  
  J Neuroinflammation 7
  
  Pages: 9-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] Aβ-synuclein mutation linked to dementia produces neurodegeneration when expressed in mouse brain2010
- Author(s)
  Fujita M, Sugama S, Sekiyama K, Sekigawa A, Tsukui T, Nakai M, Waragai M, Takenouchi T, Takamatsu Y, Wei J, Rochenstein E, Laspada AR, Masliah E, Inoue S, Hashimoto M
- Journal Title
  
  Nat Commun
  
  Volume: 1 Issue: 1 Pages: 110-110
- DOI
  10.1038/ncomms1101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500359, KAKENHI-PROJECT-21300135, KAKENHI-PROJECT-21700399
[Journal Article] Ab-synuclein mtation linked to dementia produces neurodegeneration when expressed in mouse brain.2010
- Author(s)
  Fujita M, Sugama S, Sekiyama K, Sekigawa A, et al.
- Journal Title
  
  Nature Communications
  
  Volume: 1 Pages: 110-110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] Modulation of the ATP-induced release and processing of IL-1beta in microglial cells2009
- Author(s)
  Takenouchi T, Sugama S, Iwamaru Y, Hashimoto M, Kitani H
- Journal Title
  
  Crit Rev Immunol 29
  
  Pages: 335-345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] Protective role of endogenous gangliosides for lysosomal pathology in a cellular model of synucleinopathies2009
- Author(s)
  Wei J, Fujita M, Nakai M, Waragai M, Sekigawa A, Sugama S, Takenouchi T, Masliah E, Hashimoto M
- Journal Title
  
  Am J Pathol 174
  
  Pages: 1891-1909
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] The role of the P2X7 receptor signaling pathway for the release of autolysosomes in microglial cells2009
- Author(s)
  T akenouchi T, Fujita M, Sugama S, Kitani H, Hashimoto M
- Journal Title
  
  Autophagy
  
  Volume: 5(5) Issue: 5 Pages: 723-724
- DOI
  10.4161/auto.5.5.8478
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] The role of P2X7 receptor impairs lysosomal functions and stimulates the release of autophagolysosomes in microglial cells2009
- Author(s)
  Takenouchi T, Fujita M, Sugama S, Kitani H, Hashimoto M.
- Journal Title
  
  Autophagy 5
  
  Pages: 723-724
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] The activation of P2X7 receptor impair lysosomal functions and stimulatesthe release of autophagolysosomes in microglial cells.2009
- Author(s)
  Takenouchi T, Nakai M, Iwamaru Y, Sugama, et al.
- Journal Title
  
  Journal of Immunology 182
  
  Pages: 205-262
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] Differential microglial activation between acute stress and lipopolysaccharide treatment.2009
- Author(s)
  Sugama S, Takenouchi T, Fujita M, Conti B, Hashimoto M.
- Journal Title
  
  J.Neuroimmunol 207
  
  Pages: 24-31
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] The activation of P2X7 receptor impairs lysosomal functions and stimulates the release of autophagolysosomes in microglial cells2009
- Author(s)
  Takenouchi T, Nakai M, Iwamaru Y, Sugama S, Tsukimoto M, Fujita M, Wei J, Sekigawa A, Sato M, Kojima S, Kitani H, Hashimoto M.
- Journal Title
  
  J.Immunol. 182
  
  Pages: 2051-2062
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] Microglial activation is inhibited by corticosterone in dopaminergic neurodegeneration2009
- Author(s)
  Sugama S, Takenouchi T, Kitani H, et al.
- Journal Title
  
  Journal of Neuroimmunology 208
  
  Pages: 104-114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] Microglial activation is inhibited by corticosterone in dopaminergic neurodegeneration2009
- Author(s)
  Sugama S, Takenouchi T, Kitani H, Fujita M, Hashimoto M.
- Journal Title
  
  J.Neuroimmunol. 208
  
  Pages: 104-114
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] Stress-induced microglial activation may facilitate the progression of neurodegenerative disorders2009
- Author(s)
  Sugama S
- Journal Title
  
  Medical Hypotheses
  
  Volume: 73 Issue: 6 Pages: 1031-1034
- DOI
  10.1016/j.mehy.2009.02.047
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] Microglial activation is inhibited by corticosterone in dopaminergic neurodegeneration2009
- Author(s)
  Sugama S, Takenouchi T, Kitani H, Fujita M, Hashimoto M
- Journal Title
  
  J. Neuroimmunol
  
  Volume: 208(1-2) Issue: 1-2 Pages: 104-114
- DOI
  10.1016/j.jneuroim.2009.01.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500359, KAKENHI-PROJECT-21700399
[Journal Article] Neurotoxic conversion of beta-synuclein : a novel approach to generate a transgenic mouse model of synucleinopathies?2009
- Author(s)
  Fujita M, Sekigawa A, Sekiyama K, Sugama S, Hashimoto M
- Journal Title
  
  J Neurol 256
  
  Pages: 286-292
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] Lysophospholipids and ATP mutually suppress maturation and release of IL-1 beta in mouse microglial cells using Rho-dependent pathway.2009
- Author(s)
  Takenouchi T, Iwamaru Y, Sugama S, Sato M, Hashimoto M, Kitani H
- Journal Title
  
  J.Immunol. 180
  
  Pages: 7827-7839
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] Protective role of endogeneous gangliosides for lysosomal pathology in a cellular model of synuclenopathies2009
- Author(s)
  Wei J, Fujita M, Nakai M, Waragai M, Sekigawa A, Sugama S, Takenouchi T, Masliah E, Hashimoto M
- Journal Title
  
  Am. J. Pathol
  
  Volume: 174(5) Issue: 5 Pages: 1891-909
- DOI
  10.2353/ajpath.2009.080680
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500359, KAKENHI-PROJECT-21700399
[Journal Article] Interleukin-18 in the CNS2009
- Author(s)
  Alboni S, Cervia D, Sugama S, Conti B
- Journal Title
  
  J Neuroinflammation 29
  
  Pages: 7-9
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] Possible roles of microglial cells for neurotoxicity in clinical neurode generative diseases and experimental animal models2009
- Author(s)
  Sugama S, Takenouchi T, Cho BP, Joh TH, Hashimoto M, Kitani H
- Journal Title
  
  Inflamma Allergy Drug Targets 8
  
  Pages: 277-284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] Possible roles of microglial cells for neurotoxicity in clinical neurodegenerative diseases and experimental animal models2009
- Author(s)
  Sugama S, Takenouchi T, Cho BP, Joh TH, Hashimoto M, Kitani H.
- Journal Title
  
  Inflamma Allergy Drug Targets 8
  
  Pages: 277-284
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] Differential microglial activation between acute stress and lipopolysaccharide administration2009
- Author(s)
  Sugama S, Takenouchi T, Conti B, Hashimoto M
- Journal Title
  
  J. Neuroimmunol
  
  Volume: 207(1-2) Issue: 1-2 Pages: 24-31
- DOI
  10.1016/j.jneuroim.2008.11.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500359, KAKENHI-PROJECT-21700399
[Journal Article] Stress-induced microglial activation may facilitate the progression of neurodegenerative disorders2009
- Author(s)
  Sugama S
- Journal Title
  
  Med Hypotheses 73
  
  Pages: 1031-1034
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] The role of the P2X7 receptor signaling pathway for the release of autolysosomes in microglial cells2009
- Author(s)
  Takenouchi T, Fujita M, Sugama S, Kitani H, Hashimoto M
- Journal Title
  
  Autophagy 5
  
  Pages: 723-724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] Differential microglial activation between acute stress and lipopolysaccharide treatment2009
- Author(s)
  Sugama S, Takenouchi T, Fujita M, Conti B, et al.
- Journal Title
  
  Journal of Neuroimmunology 207
  
  Pages: 24-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] Mapping of the full length and the truncated interleukin-18 receptor alpha in the mouse brain.2009
- Author(s)
  Alboni S, Cervia D, Ross B, Montanari C, Gonzalex AS, Sanchez-Alavez M, Marcondes MC, De Vries D, Sugama S, Brunello N, Blom J, Tascedda F, Conti B.
- Journal Title
  
  J.Neuroimmunol. 214
  
  Pages: 43-54
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] Neurotoxic conversion of beta-synuclein : a novel approach to generate a transgenic mouse model of synucleinopathies?2009
- Author(s)
  Fujita M, Sekigawa A, Sekiyama K, Sugama S, Hashimoto M.
- Journal Title
  
  J Neurol. 256
  
  Pages: 286-292
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] Protective role of endogenous gangliosides for lysosomal pathology in a cellular model of synucleinopathies2009
- Author(s)
  Wei J, Fujita M, Nakai M, Waragai M, Sekigawa A, Sugama S, Takenouchi T, Masliah E, Hashimoto M
- Journal Title
  
  Am J Pathol. 174
  
  Pages: 1891-1909
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] Mapping of the full length and the truncated interleukin-18 receptor alpha in the mouse brain2009
- Author(s)
  Alboni S, Cervia D, Ross B, Montanari C, Gonzalex AS, Sanchez-Alavez M, Marcondes MC, De Vries D, Sugama S, Brunello N, Blom J, Tascedda F, Conti B
- Journal Title
  
  J Neuroimmunol 214
  
  Pages: 43-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] Lysophospholipids and ATP mutually suppress maturation and release of IL-1 beta in mouse microglial cells using a Rho-dependent pathway2008
- Author(s)
  Takenouchi T, Iwamaru Y, Sugama S, et al.
- Journal Title
  
  Journal of Immunology 180
  
  Pages: 7827-39
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] Interleukin-18 and stress.2008
- Author(s)
  Sugama S, Conti B.
- Journal Title
  
  Brain res Rev. 58
  
  Pages: 85-95
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] Interleukin-18 and stress2008
- Author(s)
  Sugama S, Conti B
- Journal Title
  
  Brain Res Rev 58
  
  Pages: 85-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] Lysoshospolipids and ATP mutually suppress maturation and release of IL-1beta in mouse microglial cells using a Rho-dependent pathway2008
- Author(s)
  T akenouchi T, Iwamaru Y, Sugama S, Sato M, Hashimoto M, Kitani H
- Journal Title
  
  J. Immunol
  
  Volume: 180(12) Pages: 7827-39
- URL
  http://www.jimmunol.org/content/180/12/7827
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] Stress induced morphological microglial activation in the rodent brain : Involvement of interleukin-182007
- Author(s)
  Sugama S et al.
- Journal Title
  
  Neuroscience (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17500216
[Journal Article] Stress induced morphological microglial activation in the rodent brain : Involvement of interleukin-182007
- Author(s)
  Sugama et al.
- Journal Title
  
  Neuroscience (In pres)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500216
[Journal Article] The adrenal gland is a source of stress-induced circulating IL-18.2006
- Author(s)
  Sugama et al.
- Journal Title
  
  J Neuroimmunol 173 (1-2)
  
  Pages: 59-65
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500216
[Journal Article] Pathological dynamics of activated microglia following medial forebrain bundle transaction.2006
- Author(s)
  Cho BP, Song DY, Sugama S, et al.
- Journal Title
  
  Glia 53:1
  
  Pages: 92-102
- Data Source
  KAKENHI-PROJECT-17500216
[Journal Article] The adrenal gland is a source of stress-induced circulating IL-18.2006
- Author(s)
  Sugama S, Wang N, et al.
- Journal Title
  
  The Journal of Neuroimmunology 172:1-2
  
  Pages: 59-65
- Data Source
  KAKENHI-PROJECT-17500216
[Journal Article] The adrenal gland is a source of stress-induced circulating IL-182006
- Author(s)
  Sugama et al.
- Journal Title
  
  J Neuroimmunol 173.1-2
  
  Pages: 59-59
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17500216
[Journal Article] Interleukin-18 mRNA expression in the rat pituitary gland.2006
- Author(s)
  Wang N, Sugama S, et al.
- Journal Title
  
  The Journal of Neuroimmunology 173:1-2
  
  Pages: 117-125
- Data Source
  KAKENHI-PROJECT-17500216
[Journal Article] Modulation of the ATP-induced release and processing of IL-1beta in microglial cells.
- Author(s)
  Takenouchi T, Sugama S, Iwamaru Y, Hashimoto M, Kitani H.
- Journal Title
  
  Crit Rev Immunol 29
  
  Pages: 335-345
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] Stress-induced microglial activation may facilitate the progression of neurodegenerative disorders.
- Author(s)
  Sugama S
- Journal Title
  
  Medical Hypotheses 73
  
  Pages: 1031-1034
- Data Source
  KAKENHI-PROJECT-20500359
[Journal Article] Ab-synuclein mtation linked to dementia produces neurodegeneration when expressed in mouse brain.
- Author(s)
  Fujita M, Sugama S, Sekiyama K, Sekigawa A, et al..
- Journal Title
  
  Nature Communications 1
  
  Pages: 110-110
- Data Source
  KAKENHI-PROJECT-20500359
[Presentation] Dried bonito-derived extract regulates inflammatory responses in the central nervous system and blood brain barrier, associated with the modification of the cholinergic system2023
- Author(s)
  Hokari Y, Sekine A, Kai Y, Oikawa S, Mano A, Ohata H, Sugama S, Kakinuma Y
- Organizer
  日本生理学会第100回記念大会
- Data Source
  KAKENHI-PROJECT-21K11658
[Presentation] Stress-induced microglial activation nullified in b1 and b2 adrenergic receptor double knockout mice2018
- Author(s)
  Sugama S, Kakinuma Y
- Organizer
  The 95th Annual Meeting of the Physiological Society Meeting
- Data Source
  KAKENHI-PROJECT-15K06783
[Presentation] Loss of dopaminergic neuronss occurs in the ventral tegmental area and hypothalamus of rats following chronic stress: Possible pathogenetic loci for depression involved in Parkinson's disease2017
- Author(s)
  Sugama S, Kakinuma Y
- Organizer
  日本生理学会
- Place of Presentation
  浜松市
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-15K06783
[Presentation] Chronic restraint stress triggers the dopaminergic and noradrenergic neurodegeneration-possible role of chronic stress in the onset of Parkinson's disease2016
- Author(s)
  Sugama S, Kakinuma K
- Organizer
  日本生理学会
- Place of Presentation
  札幌市
- Year and Date
  2016-03-22
- Data Source
  KAKENHI-PROJECT-15K06783
[Presentation] 急性拘束ストレスモデルを用いた活性化ミクログリアとcFos発現ニューロンのトポグラフィー分析2014
- Author(s)
  洲鎌秀永
- Organizer
  第９１回日本生理学会
- Place of Presentation
  鹿児島市
- Data Source
  KAKENHI-PROJECT-24500465
[Presentation] Corticosteroids limit microglial activation occurring during acute stress2013
- Author(s)
  洲鎌　秀永
- Organizer
  日本生理学会（第90回）
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24500465
[Presentation] Immunological responses of astroglia in the rat brain under acute stress2012
- Author(s)
  Sugama S
- Organizer
  第89回日本生理学会大会
- Place of Presentation
  松本市
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-20500359
[Presentation] Cold stress induced morphological microglial activation and increased IL-1b expression in astroglial cells in rat brain.2011
- Author(s)
  Sugama S
- Organizer
  第88回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20500359
[Presentation] Cold stress induced morphological microglial activation and increased IL-1βexpression in astroglial cells in rat brain2011
- Author(s)
  Sugama S
- Organizer
  第88回日本生理学会
- Place of Presentation
  横浜
- Year and Date
  2011-03-28
- Data Source
  KAKENHI-PROJECT-20500359
[Presentation] Astroglial response may differ from that of microglial cells in response to acute stress.2010
- Author(s)
  Sugama S
- Organizer
  第87回日本生理学会大会
- Place of Presentation
  盛岡市
- Year and Date
  2010-05-19
- Data Source
  KAKENHI-PROJECT-20500359
[Presentation] Astroglial response may differ from that of microglial cells in response to acute stress2010
- Author(s)
  Sugama S
- Organizer
  第87回日本生理学会
- Place of Presentation
  盛岡
- Year and Date
  2010-05-19
- Data Source
  KAKENHI-PROJECT-20500359
[Presentation] Astroglial response may differ from that of microglial cells in response to acute stress2010
- Author(s)
  Sugama S
- Organizer
  第87回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20500359
[Presentation] Differential microglial activation between acute stress and lipopolysaccharide treatment2009
- Author(s)
  Sugama S
- Organizer
  第86回日本生理学会(第36回国際生理学会)
- Year and Date
  2009-07-28
- Data Source
  KAKENHI-PROJECT-20500359
[Presentation] Differential microglial activation between acute stress and lipopolysaccharide treatment2009
- Author(s)
  Sugama S
- Organizer
  第36回国際生理学会大会(第86回日本生理学会大会)
- Data Source
  KAKENHI-PROJECT-20500359
[Presentation] Stress-induced microglial activation may be triggered by noradrenergic neurons
- Author(s)
  洲鎌　秀永、柿沼　由彦
- Organizer
  日本生理学会（第９２回）
- Place of Presentation
  神戸国際会議場
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-24500465

1. HASHIMOTO Makoto (50189502)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
2. TAKENOUCHI Takato (20292518)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
3. KAKINUMA Yoshihiko (40233944)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
4. 竹中康浩 (20586789)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 上里彰仁 (90547449)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 西川徹 (00198441)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Conti Bruno

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. MIZOGUCHI Naoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 村本和世

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sugama Shuei 洲鎌 秀永

洲鎌 秀永 スガマ シユウエイ

SUGAMA Syuei 洲鎌 秀永

洲鎌 秀英 スガマ シユウエイ

SUGAMA Shuei 洲鎌 秀永

Research Projects

Research Products

Co-Researchers

Elucidation of the pathophysiology of psychiatric disorders aiming for new treatments acting on the proteoglycan sulfation mechanism

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

コリン作動系修飾物を介した血液脳関門強化と抗炎症作用による認知機能介入の可能性

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of microglia and chronic stress in the onset of Parkinson diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of microglial activation through noradrenaline in the process of neurodegenerative diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of stress-induced microglial activationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Does stress promotes neurodegenerative changes?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Katsuo extract derived from dried bonito plays a role in systemic anti-inflammation and consolidation of the blood-brain barrier to regulate higher brain functions2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evolvability of amyloidogenic proteins in human brain2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Potential application of centrifuges to protect the CNS in space and on earth2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Importance of adiponectin activity in the pathogenesis of Alzheimer's disease2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lack of interleukin-13 receptor a1 delays the loss of dopaminergic neurons during chronic stress2017

Author(s)

Journal Title

Data Source

[Journal Article] Letter to the Editor Re:"Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend of foe?" by Ong et al. Brain Behavior and Immunity, 2016.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Loss of dopaminergic neurons occurs in the ventral tegmental area and hypothalamus of rats following chronic stress: Possible pathogenetic loci for depression involved in Parkinson's disease2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Combined immunotherapy with “anti-insulin resistance” therapy as a novel therapeutic strategy against neurodegenerative diseases.2016

Author(s)

Sugama Shuei 洲鎌秀永

洲鎌秀永スガマシユウエイ

SUGAMA Syuei 洲鎌秀永

洲鎌秀英スガマシユウエイ

SUGAMA Shuei 洲鎌秀永