Isshiki Masashi 一色政志

… Alternative Names

ISSHIKI Masashi 一色政志

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Researcher Number	70302734
Other IDs
Affiliation (Current)	2025: 埼玉医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2012: 東京大学, 医学部附属病院(大学院医学系研究科分子血管内分泌学講座), 特任准教授 2012: 東京大学, 医学部附属病院, 准教授 2009 – 2011: The University of Tokyo, 医学部附属病院, 特任准教授 2007 – 2008: The University of Tokyo, Faculty of Medicine, Associa Professor 2007 – 2008: 東京大学, 医学部附属病院, 助教 … More 2002 – 2006: 東京大学, 医学部附属病院, 助手 2003: 東京大学, 医学系研究科, 助手 2002 – 2003: 東京大学, 大学院・医学系研究科, 助手 Less
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine Except Principal Investigator Circulatory organs internal medicine / Endocrinology / Circulatory organs internal medicine / Biomedical engineering/Biological material science
Keywords	Principal Investigator イメージング / PLC / FRET / マイクロドメイン / 循環器・高血圧 / 細胞生物学 / 高血圧 / シグナル伝達 / imaging / nitric oxide (NO) … More / cameleon / calcium signal / endothelium / カベオラ / 一酸化窒素(NO) / カメレオン / カルシウムシグナル / 血管内皮細胞 / 循環器 / 内皮機能 … More Except Principal Investigator 酸化ストレス / 腎障害 / aldosterone / Metabolic syndrome / adrenomedullin / Oxidative stress / アルドステロン / メタボリックシンドローム / アドレノメデュリン / サイトカイン / タウリン / TNFα / PPARγ / LOX-1 / 動脈硬化 / レクチン様酸化LDL受容体-1(LOX-1) / salt / inflammation / Organ regeneration / 脂肪細胞 / 遺伝子変異 / 食塩 / 炎症 / 臓器再生 / platinum / glucose / 加齢 / 肥満 / 交感神経 / 白金 / 糖 / tumor necrosis factor-α (TNFα) / PPARγ knockout mice / lpr mice / atherosclerosis / peroxisome proliferator-activated receptor-γ (PPARγ) / thiazolidinediones / cytokine / lectin-like oxidized LDL receptor-1 (LOX-1) / TNAα / lprマウス / PPARγノックアウトマウス / 1prマウス / peroxisome proliferator-activated receptor-γ(PPARγ) / チアゾリジン誘導体 / 活性酸素種 / 一酸化窒素 / システイン / 内皮細胞 / 抵抗血管 / 大動脈 / CSEノックアウトマウス / 内皮 / 平滑筋 / 血管 / リンパ管 / 微小循環 / ガスバイオロジー / 硫化水素 / フィジオーム / 生体システム / 遺伝子改変動物 / 抗酸化物質 / peroxisome proliferator-activated receptor γ / 酸化低比重リポ蛋白(LDL) Less

Improvement of peripheral microcirculation by a new gas transmitter delivery
- Principal Investigator
  
  MIZUNO Risuke
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  The University of Tokyo
Imaging of intracellular dynamics of Ca^<2+>-influx-associated molecules and its physiological significance in endothelial cells.Principal Investigator
- Principal Investigator
  
  ISSHIKI Masashi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
Mechanisms and physiology of Ca^<2+> influx by spatial regulation ofcaveolae in endothelial cellsPrincipal Investigator
- Principal Investigator
  
  ISSHIKI Masashi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
Targeting oxidative stress and new therapy in metabolic syndrome
- Principal Investigator
  
  FUJITA Toshiro
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Endocrinology
- Research Institution
  The University of Tokyo
Therapeutic potency of antioxidative peptide in metabolic syndrome
- Principal Investigator
  
  SHIMOSAWA Tatsuo
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
Imaging and analysis of subplasmalemmal Ca^<2+> dynamics by FRETPrincipal Investigator
- Principal Investigator
  
  ISSHIKI Masashi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
遺伝子工学を用いた動脈硬化形成とその防御機構の解析―LOX-1とPPARγの役割
- Principal Investigator
  
  TOSHIRO Fujita
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
Role of LOX-1 and protective effect of PPARγ in the development of atherosclerosis
- Principal Investigator
  
  ANDO Katsuyuki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo

All 2013 2012 2011 2010 2009 2008 2007 2006 2004

All Journal Article Presentation

[Journal Article] Aldosterone enhances ligand-stimulatednitric xoide production in endothelial cells2008
- Author(s)
  Mutoh A, Isshiki M, Fujita T.
- Journal Title
  
  Hypertens Res 31
  
  Pages: 1811-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590852
[Journal Article] Aldosterone enhances lig and-stimulated Nitric Oxide Production in Endothelial cells.2008
- Author(s)
  Mutoh A.,Isshiki M., Fujita T.
- Journal Title
  
  Hypertens Res 31
  
  Pages: 1811-1820
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590852
[Journal Article] Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice.2006
- Author(s)
  Yamamoto K, Sokabe T, Matsumoto T, Yoshimura K, Shibata M, Ohura N, Fukuda T, Sato T, Sekine K, Kato S, Isshiki M, Fujita T, Kobayashi M, Kawamura K, Masuda H, Kamiya A, Ando J
- Journal Title
  
  Nature Med 12
  
  Pages: 133-137
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590660
[Journal Article] Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice.2006
- Author(s)
  Yamamoto K, Sokabe T, Matsumoto T, Yoshimura K, Shibata M, Ohura N, Fukuda T, Sato T, Sekine K, Kato S, Isshiki M, Fujita T, Kobayashi M, Kawamura K, Masuda H, Kamiya A, Ando J.
- Journal Title
  
  Nature Med 12
  
  Pages: 133-7
- Data Source
  KAKENHI-PROJECT-17209034
[Journal Article] Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice.2006
- Author(s)
  Yamamoto K, Sokabe T, Matsumoto T, Yoshimura K, Shibata M, Ohura N, Fukuda T, Sato T, Sekine K, Kato S, Isshiki M, Fujita T, Kobayashi M, Kawamura K, Masuda H, Kamiya A, Ando J.
- Journal Title
  
  Nature Med 12
  
  Pages: 133-137
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590660
[Journal Article] Subcortical Ca^<2+> waves sneaking under the plasma membrane in endothelial cells.2004
- Author(s)
  Isshiki, M., Mutoh, A., Fujita, T.
- Journal Title
  
  Circulation Research 95
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590724
[Journal Article] Subcortical Ca^<2+> waves sneaking under the plasma membrane in endothelial cells.2004
- Author(s)
  Isshiki.M., Mutoh, A., Fujita, T.
- Journal Title
  
  Circulation Research 95
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590724
[Presentation] 微小-リンパ循環学の基礎と臨床獣医学への橋渡しパネルディスカッション「リンパ節廓清(切除)は必要か」2013
- Author(s)
  水野理介、一色政志、藤田敏郎
- Organizer
  第85回獣医麻酔外科学会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-22500403
[Presentation] High concentration of salt dysfunctions lymphatic activity through Na^+-K^+-ATPase-dependent mechanisms2012
- Author(s)
  水野理介、一色政志、西本光宏、藤田敏郎
- Organizer
  Gordon Research Conferences
- Place of Presentation
  Ventura Beach Marriott, USA(招待講演)
- Year and Date
  2012-03-06
- Data Source
  KAKENHI-PROJECT-22500403
[Presentation] High salt inhibits lymphatic transport function through regulation of Na+-K+-ATPase activity2012
- Author(s)
  野理介、一色政志、西本光宏、藤田敏郎
- Organizer
  American Heart Association Scientific Sessions2012
- Place of Presentation
  ロスアンゼルスアメリカ合衆国
- Data Source
  KAKENHI-PROJECT-22500403
[Presentation] リンパ系は輸送管と交換管として機能する微小循環系である2012
- Author(s)
  水野理介、一色政志、藤田敏郎
- Organizer
  第153回日本獣医学会学術集会
- Place of Presentation
  大宮市
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-22500403
[Presentation] 高濃度NaClはリンパ管のポンプ機能を阻害する:Na+-K+-ATPaseの関与2012
- Author(s)
  水野理介、一色政志、西本光宏、藤田敏郎
- Organizer
  第35回日本高血圧学会総会
- Place of Presentation
  名古屋市
- Year and Date
  2012-09-21
- Data Source
  KAKENHI-PROJECT-22500403
[Presentation] FRET法およびピロアンチモン酸法によるカベオラ小胞内Ca^<2+>イメージング2012
- Author(s)
  一色政志, ほか
- Organizer
  第85回日本内分泌学会総会
- Place of Presentation
  名古屋
- Year and Date
  2012-04-21
- Data Source
  KAKENHI-PROJECT-21590948
[Presentation] High concentration of salt dysfunctions lymphatic activity through Na+-K+-ATPase-dependent mechanisms2012
- Author(s)
  水野理介、一色政志、西本光宏、藤田敏郎
- Organizer
  Gordon Research Conferences Molecular Mechanisms in Lymphatic Function & Disease
- Place of Presentation
  Ventura Beach Marriott サンフランシスコアメリカ合衆国
- Year and Date
  2012-03-06
- Data Source
  KAKENHI-PROJECT-22500403
[Presentation] A FRET-based Sensor Detects Caveolae are Spatially Distinct Ca^<2+> Stores in Endothelial Cells2012
- Author(s)
  一色政志, ほか
- Organizer
  第76回日本循環器学会学術総会
- Place of Presentation
  福岡
- Year and Date
  2012-03-17
- Data Source
  KAKENHI-PROJECT-21590948
[Presentation] リンパ系は輸送管と交換管として機能する微小循環系である2012
- Author(s)
  水野理介、一色政志、藤田敏郎
- Organizer
  第153回日本獣医学会学術集会
- Place of Presentation
  大宮ソニックシティ(招待講演)
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-22500403
[Presentation] 内皮細胞膜直下カベオラ小胞はCa^<2+>放出可能なCa^<2+>ストアサブコンパートメントとして機能する2012
- Author(s)
  一色政志, ほか
- Organizer
  第49回日本臨床分子医学会学術集会
- Place of Presentation
  京都
- Year and Date
  2012-04-14
- Data Source
  KAKENHI-PROJECT-21590948
[Presentation] Intra-ER Ca^<2+> flow recharges preferentially to ER subcompartments at caveolin-rich cell edges in endothelial cells2011
- Author(s)
  一色政志, ほか
- Organizer
  第84回日本内分泌学会総会
- Place of Presentation
  神戸
- Year and Date
  2011-04-21
- Data Source
  KAKENHI-PROJECT-21590948
[Presentation] 藤田敏郎摘出マウス腹壁抵抗血管におけるL-システイン-HS経路による緊張性制御機構の解析2011
- Author(s)
  水野理介、一色政志、高良洋平、西本光宏
- Organizer
  第34回日本高血圧学会総会
- Place of Presentation
  宇都宮市
- Year and Date
  2011-10-20
- Data Source
  KAKENHI-PROJECT-22500403
[Presentation] Intra-Endoplasmic Reticulum(ER) Ca^<2+> Flow Recharges Preferentially to ER Subcompartments at Caveolin-Rich Cell Edges in Endothelial Cells American Heart Association2011
- Author(s)
  Masashi Isshiki, et al.
- Organizer
  Scientific Meeting Sessions
- Place of Presentation
  Orlando, FL
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PROJECT-21590948
[Presentation] Stim1は血管内皮細胞においてTNFα刺激によるLOX-1発現を制御する2011
- Author(s)
  西本光宏、一色政志, ほか
- Organizer
  第34回日本高血圧学会総会
- Place of Presentation
  宇都宮
- Year and Date
  2011-10-22
- Data Source
  KAKENHI-PROJECT-21590948
[Presentation] 内皮細胞膜直下カベオラはCa^<2+>放出のためのストアとして働く2011
- Author(s)
  一色政志, ほか
- Organizer
  第34回日本高血圧学会総会
- Place of Presentation
  宇都宮
- Year and Date
  2011-10-22
- Data Source
  KAKENHI-PROJECT-21590948
[Presentation] 摘出マウス腹壁抵抗血管におけるL-システイン-H_2S経路による緊張性制御機構の解析2011
- Author(s)
  水野理介、一色政志、高良洋平、西本光宏、藤田敏郎
- Organizer
  第34回日本高血圧学会総会
- Place of Presentation
  栃木県総合文化センター
- Year and Date
  2011-10-20
- Data Source
  KAKENHI-PROJECT-22500403
[Presentation] L-システインは内因性活性酸素種依存的に内皮依存性血管収縮を惹起する2010
- Author(s)
  水野理介、一色政志、藤田敏郎
- Organizer
  第33回日本高血圧学会総会
- Place of Presentation
  福岡市
- Year and Date
  2010-10-15
- Data Source
  KAKENHI-PROJECT-22500403
[Presentation] L-システインは内因性活性酸素種依存的に内皮依存性血管収縮を惹起する2010
- Author(s)
  水野理介、一色政志、藤田敏郎
- Organizer
  第33回日本高血圧学会総会
- Place of Presentation
  福岡国際会議場(福岡県)
- Year and Date
  2010-10-15
- Data Source
  KAKENHI-PROJECT-22500403
[Presentation] 内皮細胞膜カベオラ集中部位でのCa2+ wave発火には局所IP3産生開始とダイナミックな局所ER内Ca2+調節機構の存在を伴う2010
- Author(s)
  一色政志
- Organizer
  第33回日本高血圧学会
- Place of Presentation
  福岡国際会議場(福岡県)
- Year and Date
  2010-10-15
- Data Source
  KAKENHI-PROJECT-21590948
[Presentation] 内皮細胞膜カベオラ集中部位でのCa^<2+> wave発火には局所IP_3産生開始とダイナミックな局所ER内Ca^<2+>調節機構の存在を伴う2010
- Author(s)
  一色政志, ほか
- Organizer
  第33回日本高血圧学会総会
- Place of Presentation
  福岡
- Year and Date
  2010-10-15
- Data Source
  KAKENHI-PROJECT-21590948
[Presentation] 低用量エプレレノンはMR 非依存的に内皮機能を改善する2009
- Author(s)
  武藤明子, 一色政志, 西本光宏, 藤田敏郎
- Organizer
  日本内分泌学会
- Place of Presentation
  前橋
- Year and Date
  2009-04-24
- Data Source
  KAKENHI-PROJECT-19590852
[Presentation] Eplerenone down-regulaes caveolin-1and improves endothelial function bymechanisms independent of Mrantagonism2009
- Author(s)
  Muto-A, Isshiki M, Nishimoto-M, Fujita T.
- Organizer
  The 2^<nd>International Aldosterone Forum in Japan(Award winners' oral presentation)
- Place of Presentation
  東京
- Year and Date
  2009-05-17
- Data Source
  KAKENHI-PROJECT-19590852
[Presentation] 血管内皮細胞におけるStim1はストア依存性Ca^<2+>流入を制御してeNOS活性とリンクする2009
- Author(s)
  西本光宏、一色政志, ほか
- Organizer
  第32回日本高血圧学会総会
- Place of Presentation
  大津
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21590948
[Presentation] エプレレノンによる肥満高血圧ラットの血管内皮機能改善とその機序2008
- Author(s)
  武藤明子、一色政志、西本光宏、藤田敏郎
- Organizer
  日本内分泌学会
- Place of Presentation
  青森
- Year and Date
  2008-05-17
- Data Source
  KAKENHI-PROJECT-19590852
[Presentation] エプレレノンによるメタボリックシンドロームラットの血管内皮機能改善とその機序2008
- Author(s)
  武藤明子、一色政志、西本光宏、藤田敏郎
- Organizer
  日本高血圧学会
- Place of Presentation
  札幌
- Year and Date
  2008-10-10
- Data Source
  KAKENHI-PROJECT-19590852
[Presentation] Low-dose eplerenone down-regulatescaveolin-1 and improves endothelialfunction by mechanisms independent of Mrantagonism2008
- Author(s)
  Mutoh-A, Isshiki M. and Fujita T.
- Organizer
  AHA Scientific Sessions 2008 (oralpresentation)
- Place of Presentation
  ニューオーリンズ、米国
- Year and Date
  2008-11-10
- Data Source
  KAKENHI-PROJECT-19590852
[Presentation] アルドステロンはリガンド刺激によるeNOSリン酸化の増強を介して血管内皮NO 産生を亢進する2007
- Author(s)
  武藤明子, 高良洋平, 一色政志, 藤田敏郎
- Organizer
  日本高血圧学会
- Place of Presentation
  那覇
- Year and Date
  2007-10-26
- Data Source
  KAKENHI-PROJECT-19590852
[Presentation] 血管内皮細胞の局所Ca^<2+>シグナルを構成する膜直下サブドメイン2007
- Author(s)
  一色政志
- Organizer
  日本内分泌学会
- Place of Presentation
  東京
- Year and Date
  2007-06-15
- Data Source
  KAKENHI-PROJECT-19590852
[Presentation] LOX-1 upregulation shifts endocytosisof cholera toxin from caveolae-mediated tononcaveolae-mediated pathway inendothelial cells2007
- Author(s)
  Mutoh-A, Isshiki and M. Fujita T.
- Organizer
  AHA Scientific Sessions 2007(poster presentation)
- Place of Presentation
  オーランド、米国
- Year and Date
  2007-11-08
- Data Source
  KAKENHI-PROJECT-19590852

1. TOSHIRO Fujita (10114125)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
2. SHIMOSAWA Tatsuo (90231365)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. TAKAHASHI Katsutoshi (00292863)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. ANDO Katsuyuki (60184313)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
5. MIZUNO Risuke (30273080)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
6. IIRI Taro (90313022)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YAMAMOTO Kimiko (00323618)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NAGASE Miki (60302733)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Isshiki Masashi 一色 政志

ISSHIKI Masashi 一色 政志

Research Projects

Research Products

Co-Researchers

Improvement of peripheral microcirculation by a new gas transmitter delivery

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Imaging of intracellular dynamics of Ca^<2+>-influx-associated molecules and its physiological significance in endothelial cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms and physiology of Ca^<2+> influx by spatial regulation ofcaveolae in endothelial cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Targeting oxidative stress and new therapy in metabolic syndrome

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Therapeutic potency of antioxidative peptide in metabolic syndrome

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Imaging and analysis of subplasmalemmal Ca^<2+> dynamics by FRETPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

遺伝子工学を用いた動脈硬化形成とその防御機構の解析―LOX-1とPPARγの役割

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of LOX-1 and protective effect of PPARγ in the development of atherosclerosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Aldosterone enhances ligand-stimulatednitric xoide production in endothelial cells2008

Author(s)

Journal Title

Data Source

[Journal Article] Aldosterone enhances lig and-stimulated Nitric Oxide Production in Endothelial cells.2008

Author(s)

Journal Title

Data Source

[Journal Article] Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice.2006

Author(s)

Journal Title

Data Source

[Journal Article] Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Subcortical Ca^<2+> waves sneaking under the plasma membrane in endothelial cells.2004

Author(s)

Journal Title

Description

Data Source

Isshiki Masashi 一色政志

ISSHIKI Masashi 一色政志