KIMURA Atsuomi 木村敦臣

Researcher Number	70303972
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 大阪大学, 大学院医学系研究科, 准教授 2014 – 2021: 大阪大学, 医学系研究科, 准教授 2013 – 2016: 大阪大学, 医学(系)研究科(研究院), 准教授 2012: 大阪大学, 大学院・医学系研究科, 准教授 2008 – 2012: Osaka University, 医学系研究科, 准教授 … More 2007: 阪大, 医学(系)研究科(研究院), 助教授 2006: 大阪大学, 大学院医学系研究科, 助教授 2003 – 2005: 大阪大学, 大学院・医学系研究科, 助教授 2003: 大阪大学, 医学系研究科, 助教授 2001 – 2002: 大阪大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Biomedical engineering/Biological material science / Basic Section 90110:Biomedical engineering-related / Medium-sized Section 34:Inorganic/coordination chemistry, analytical chemistry, and related fields / Biomedical engineering/Biomaterial science and engineering / Radiation science / Radiation science Except Principal Investigator Biomedical engineering/Biomaterial science and engineering / Radiation science / Radiation science / Biological Sciences / Science and Engineering
Keywords	Principal Investigator 超偏極希ガス / 超偏極キセノン / MRI / 難治性肺疾患 / 新薬探索 / 前臨床評価 / 肺機能診断 / 慢性閉塞性肺疾患 / 生体磁気共鳴計測 / 肺機能 … More / MRS / 拡散 / 換気 / 脳機能 / 肺癌検出 / 超高感度 / 葉酸修飾酸化鉄ナノ粒子 / リポソーム / 酸化鉄ナノ粒子 / ナノメディスン / 肺癌検出システム / 磁性ナノ粒子 / 新生体素材開発 / 頑強化と持続可能化 / 熱可塑性ポリウレタン / hyper-CEST / stopped-flow / 新素材解析 / 熱可塑性ポリウレタン / Silk Fibroin / Cellulose Nanofiber / stopped-flow　hyper-CEST / 高分子自由体積 / 超偏極キセノン生成装置の改良 / 超偏極キセノンNMR / 医用画像 / バイオイメージング / 肺がん / 肺疾患 / 肺癌 / MRI肺機能診断システム / ピルビン酸エチル / 完全偏極キセノン / 病態モデル / 超偏極 / 前臨床評価系 / イメージング / 肺MRI画像 / bSSFP法 / 偏極率 / 脳内緩和時間 / 灌流 / シネMRI画像 / 肺・脳機能連関 / 脳血流量 / 潅流 / 慢性閉塞性肺疾患(COPD) / 磁気共鳴イメージング(MRI) / 超偏極希ガス製造装置 / 連続フロー型 / 肺機能診断法 / 局所肺機能 / 核磁気共鳴 / 連続フロー … More Except Principal Investigator MRI / MRS / Xe NMR / 磁性ナノ粒子 / 磁気温熱療法 / 磁気粒子イメージング / 超偏極希ガス / 生体温度測定 / NMR / 磁気送達 / Lung Function / Brain Function / Mouse / Hyperpolarized Noble Gas / エマルジョン / 肺機能評価 / 肺画像 / 肺機能測定 / 脳機能測定 / マウス / ｐＨ / 水素イオン指数 / 核磁気共鳴 / 化学交換速度 / コンピュータシミュレーション / pH / 核磁気共鳴撮像法 / 化学交換飽和移動 / 磁場ゼロ線 / 薬剤送達システム / 医用画像 / ナノ」粒子メディスン / バイオイメージング / 磁性体ナノ粒子 / 動物実験 / 高感度 / 高分解能 / 画像再構成 / 磁場セロ線 / 細胞追跡法 / 温度感受性リポソーム / 磁気送達法 / ナノ粒子メディスン / 希釈ガス / 偏極率 / 磁気的相互作用 / 磁化移動 / エンタルピー / 平衡定数 / カリックスアレン / 包接相互作用 / Xe-129 / 二次元NMR / エマルジェン / 体内温度測定 / 多核種内部基準法 / 温度依存性 / Xe-129化学シフト / 超偏極希ガスNMR / 配向パラメーター / ジニコナゾール / ウニコナゾール / 直接結合定数 / 絶対構造決定 / 光学純度 / キラル液晶 / 光学異性体 Less

Enhancement of robustness and sustainability of hyperpolarized xenon NMR and novel establishments as a fundamental technology for the development of new materialsPrincipal Investigator
- Principal Investigator
  
  Kimura Atsuomi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 34:Inorganic/coordination chemistry, analytical chemistry, and related fields
- Research Institution
  Osaka University
ナノメディスンと超偏極希ガスMRIの融合による超高感度肺癌検出システムの開発Principal Investigator
- Principal Investigator
  
  木村敦臣
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Osaka University
Development of a system for optimizing magnetic targeting and magnetic hyperthermia treatment using newly-developed magnetic particle imaging
- Principal Investigator
  
  Murase Kenya
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Osaka University
Development and application of an innovative pulmonary functional diagnostic system using hyperpolarized noble gas MRI aiming at complete polarizationPrincipal Investigator
- Principal Investigator
  
  Kimura Atsuomi
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Osaka University
Establishment of elemental techniques for magnetic particle imaging aiming at application to nanoparticle medicine
- Principal Investigator
  
  Kenya Murase
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Osaka University
Development of a new method for quantifying chemical exchange rate and visualizing pH using CEST MRI
- Principal Investigator
  
  MURASE Kenya
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Osaka University
Development of preclinical system based on pulmonary functional imaging by hyperpolarized Xe MRIPrincipal Investigator
- Principal Investigator
  
  Kimura Atsuomi
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Osaka University
Development andApplication of Methodology of Magnetic Resonance Measurement of Hyperpolarized Noble Gas Contributable to Physiological Diagnosis.Principal Investigator
- Principal Investigator
  
  KIMURA Atsuomi
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Osaka University
超偏極希ガスのMRI/MRSによる新規肺機能診断法の開発に関する研究Principal Investigator
- Principal Investigator
  
  木村敦臣
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Radiation science
- Research Institution
  Osaka University
簡易連続型超偏極希ガス生成装置の試作と水素や炭素核の高感度MRI実験への応用
- Principal Investigator
  
  藤原英明
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Osaka University
超偏極希ガスの連続フロー型製造装置開発と脳機能磁気共鳴研究への応用Principal Investigator
- Principal Investigator
  
  木村敦臣
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  Osaka University
Applied Clinical Study on Hyperpolarized Noble Gas MRI/MRS using Pathologic Model Animal
- Principal Investigator
  
  FUJIWARA Hideaki
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Osaka University
液晶NMR法におけるキラル液晶系の利用と天然分子の絶対構造決定の開発
- Principal Investigator
  
  FUJIWARA Hideaki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Osaka University
超偏極希ガス簡易供給装置の開発と高感度磁気共鳴による脳機能計測の研究
- Principal Investigator
  
  藤原英明
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University

[Book] Hyperpolarized and Inert Gas MRI in Research and Medicine2017
- Author(s)
  Imai H, Kimura A, Fujiwara H.
- Total Pages
  15
- Publisher
  Elsevier
- ISBN
  9780128036754
- Data Source
  KAKENHI-PROJECT-15H03006
[Book] Hyperpolarized Xenon-129 Magnetic Resonance2015
- Author(s)
  Kimura A, Imai H, Fujiwara H
- Total Pages
  483
- Publisher
  Cambridge: Royal Society of Chemistry
- Data Source
  KAKENHI-PROJECT-15H03006
[Book] Hyperpolarized Xenon-129 Magnetic Resonance.2015
- Author(s)
  Kimura A, Imai H, Fujiwara H.
- Total Pages
  16
- Publisher
  Royal Society of Chemistr
- Data Source
  KAKENHI-PROJECT-24300163
[Book] Hyperpolarized Xenon-129 Magnetic Resonance2015
- Author(s)
  Kimura A, Imai H, Fujiwara H
- Total Pages
  483
- Publisher
  Cambridge: Royal Society of Chemistry
- Data Source
  KAKENHI-PROJECT-24300163
[Book] Quantitation in Biomedical Imaging with PET and MRI, ICS1265.2004
- Author(s)
  T.Wakayama, T.Oose, M.Narazaki, A.Kimura, H.Fujiwara
- Total Pages
  4
- Publisher
  Elsevier, Amsterdam
- Data Source
  KAKENHI-PROJECT-14370277
[Book] Quantitation in Biomedical Imaging with PET and MRI, ICS1265.2004
- Author(s)
  H.Fujiwara, A.Kimura, T.Wakayama
- Total Pages
  8
- Publisher
  Elsevier, Amsterdam
- Data Source
  KAKENHI-PROJECT-14370277
[Book] Quantitation in Biomedical Imaging with RET and MRI, ICS1265.2004
- Author(s)
  M.Narazaki, T.Wakayama, A.Kimura, H.Fujiwara
- Total Pages
  4
- Publisher
  Elsevier, Amsterdam
- Data Source
  KAKENHI-PROJECT-14657215
[Book] Quantitation in Biomedical Imaging with PET and MRI, ICS1265.2004
- Author(s)
  Y.Kawata, T.Kamiya, H.Miura, A.Kimura, H.Fujiwara
- Total Pages
  4
- Publisher
  Elsevier, Amsterdam
- Data Source
  KAKENHI-PROJECT-14657215
[Book] Quantitation in Biomedical Imaging with PET and MRI, ICS1265.2004
- Author(s)
  T.Wakayama, T.Oose, M.Narazaki, A.Kimura, H.Fujiwara
- Total Pages
  4
- Publisher
  Elsevier, Amsterdam
- Data Source
  KAKENHI-PROJECT-14657215
[Book] Quantitation in Biomedical Imaging with PET and MRI, ICS1265.2004
- Author(s)
  M.Narazaki, T.Wakayama, A.Kimura, H.Fujiwara
- Total Pages
  4
- Publisher
  Elsevier, Amsterdam
- Data Source
  KAKENHI-PROJECT-14370277
[Book] Quantitation in Biomedical Imaging with PET and MRI, ICS1265.2004
- Author(s)
  H.Fujiwara, A.Kimura, T.Wakayama
- Total Pages
  8
- Publisher
  Elsevier, Amsterdam
- Data Source
  KAKENHI-PROJECT-14657215
[Book] Quantitation in Biomedical Imaging with PET and MRI, ICS1265.2004
- Author(s)
  Y.Kawata, T.Kamiya, H.Miura, A.Kimura, H.Fujiwara
- Total Pages
  4
- Publisher
  Elsevier, Amsterdam
- Data Source
  KAKENHI-PROJECT-14370277
[Journal Article] Targeted Imaging of Lung Cancer with Hyperpolarized 129Xe MRI Using Surface-Modified Iron Oxide Nanoparticles as Molecular Contrast Agents.2022
- Author(s)
  Kimura A, Utsumi S, Shimokawa A, Nishimori R, Hosoi R, Stewart NJ, Imai H, Fujiwara H.
- Journal Title
  
  Cancers (Basel).
  
  Volume: 14 Pages: 6070-6070
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K20411
[Journal Article] Quantitative assessment of regional lung ventilation in emphysematous mice using hyperpolarized 129Xe MRI with a continuous flow hyperpolarizing system.2022
- Author(s)
  Wakayama T, Ueyama T, Imai F, Kimura A, Fujiwara H.
- Journal Title
  
  Magn Reson Imaging.
  
  Volume: 92 Pages: 88-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K20411
[Journal Article] Inflammation during Lung Cancer Progression and Ethyl Pyruvate Treatment Observed by Pulmonary Functional Hyperpolarized 129Xe MRI in Mice2021
- Author(s)
  Kimura Atsuomi、Utsumi Seiya、Shimokawa Akihiro、Nishimori Renya、Stewart Neil J.、Kamada Yoshihiro、Imai Hirohiko、Fujiwara Hideaki
- Journal Title
  
  Contrast Media & Molecular Imaging
  
  Volume: 2021 Pages: 1-10
- DOI
  10.1155/2021/9918702
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08383, KAKENHI-PROJECT-23K20411
[Journal Article] Analysis of NMR Adsorption Isotherms of Zeolite ZSM-5: Adsorption Profiles Derived from the Pressure and Temperature Dependences of <sup>129</sup>Xe NMR Chemical Shift and Signal Intensity2021
- Author(s)
  FUJIWARA Hideaki、IMAI Hirohiko、ADACHI Yuko、KIMURA Atsuomi
- Journal Title
  
  Anal. Sci.
  
  Volume: 37 Issue: 12 Pages: 1803-1810
- DOI
  10.2116/analsci.21P202
- NAID
  130008127597
- ISSN
  0910-6340, 1348-2246
- Year and Date
  2021-12-10
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K18980
[Journal Article] Multiplexed 129Xe HyperCEST MRI Detection of Genetically Reconstituted Bacterial Protein Nanoparticles in Human Cancer Cells2020
- Author(s)
  Mizushima Ryota、Inoue Kanako、Fujiwara Hideaki、Iwane Atsuko H.、Watanabe Tomonobu M.、Kimura Atsuomi
- Journal Title
  
  Contrast Media & Molecular Imaging
  
  Volume: 2020 Pages: 1-10
- DOI
  10.1155/2020/5425934
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05409, KAKENHI-PROJECT-23K20411
[Journal Article] Stability Enhancement of <sup>129</sup>Xe Hyperpolarizing System Using Alkali Metal Vapor in Spin-Exchange Optical Pumping Cell to Achieve High NMR Sensitivity2019
- Author(s)
  Fujiwara H, Imai H, Kimura A.
- Journal Title
  
  Anal. Sci.
  
  Volume: 35 Issue: 8 Pages: 869-873
- DOI
  10.2116/analsci.19P047
- NAID
  130007689343
- ISSN
  0910-6340, 1348-2246
- Year and Date
  2019-08-10
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H03006
[Journal Article] Adipose Tissue-Derived Stem Cells Have the Ability to Differentiate into Alveolar Epithelial Cells and Ameliorate Lung Injury Caused by Elastase-Induced Emphysema in Mice.2019
- Author(s)
  Fukui E, Funaki S, Kimura K, Momozane T, Kimura A, Chijimatsu R, Kanzaki R, Kanou T, Ose N, Minami M, Miyagawa S, Sawa Y, Okumura M, Shintani Y.
- Journal Title
  
  Stem Cells Int.
  
  Volume: 2019 Pages: 5179172-5179172
- DOI
  10.1155/2019/5179172
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H03006, KAKENHI-PROJECT-18J01264, KAKENHI-PROJECT-18K16417
[Journal Article] Ethyl Pyruvate Improves Pulmonary Function in Mice with Bleomycin-induced Lung Injury as Monitored with Hyperpolarized 129Xe MR Imaging.2018
- Author(s)
  Hodono S, Shimokawa A, Stewart NJ, Yamauchi Y, Nishimori R, Yamane M, Imai H, Fujiwara H, Kimura A.
- Journal Title
  
  Magn Reson Med Sci.
  
  Volume: 17 Pages: 331-337
- NAID
  130007496955
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03006
[Journal Article] Continuous flow production of concentrated hyperpolarized xenon gas from a dilute xenon gas mixture by buffer gas condensation.2017
- Author(s)
  Imai H, Yoshimura H, Kimura A, Fujiwara H.
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 7352-7352
- DOI
  10.1038/s41598-017-07695-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H03006, KAKENHI-PROJECT-15K01283
[Journal Article] Treatment response of ethyl pyruvate in a mouse model of chronic obstructive pulmonary disease studied by hyperpolarized 129Xe MRI.2017
- Author(s)
  Kimura A, Yamauchi Y, Hodono S, Stewart NJ, Hosokawa O, Hagiwara Y, Imai H, Fujiwara H.
- Journal Title
  
  Magn Reson Med
  
  Volume: 78 Pages: 721-729
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03006
[Journal Article] Treatment response of ethyl pyruvate in a mouse model of chronic obstructive pulmonary disease studied by hyperpolarized 129Xe MRI.2016
- Author(s)
  Kimura A, Yamauchi Y, Hodono S, Stewart NJ, Hosokawa O, Hagiwara Y, Imai H, Fujiwara H.
- Journal Title
  
  Magn Reson Med
  
  Volume: 印刷中 Issue: 2 Pages: 721-729
- DOI
  10.1002/mrm.26458
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03006, KAKENHI-PROJECT-15K01283
[Journal Article] Hyperpolarized 129Xe MRI Using Isobutene as a New Quenching Gas2016
- Author(s)
  Hodono S, Imai H, Yamauchi Y, Kawamura A, Matsumoto H, Okumura S, Fujiwara H, Kimura A.
- Journal Title
  
  NMR Biomed
  
  Volume: 29 Issue: 10 Pages: 1414-1419
- DOI
  10.1002/nbm.3585
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H03006, KAKENHI-PROJECT-15K01283
[Journal Article] Regional fractional ventilation mapping in spontaneously breathing mice using hyperpolarized 129Xe MRI.2015
- Author(s)
  Imai H, Matsumoto H, Miyakoshi E, Okumura S, Fujiwara H, Kimura A.
- Journal Title
  
  NMR Biomed
  
  Volume: 28 Pages: 24-29
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24300163
[Journal Article] Regional fractional ventilation mapping in spontaneously breathing mice using hyperpolarized 129Xe MRI.2015
- Author(s)
  Imai H, Matsumoto H, Miyakoshi E, Okumura S, Fujiwara H, Kimura A.
- Journal Title
  
  NMR Biomed
  
  Volume: 28 Pages: 24-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H03006
[Journal Article] Small animal imaging with hyperpolarized 129Xe magnetic resonance.2014
- Author(s)
  Imai H, Kimura A, Fujiwara H.
- Journal Title
  
  Anal Sci
  
  Volume: 30 Pages: 157-166
- NAID
  130004442237
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24300163
[Journal Article] Direct Imaging of Alveolar Gas Uptake with Hyperpolarized 129xe Ultra-short Echo-Time MRI and Its Application to Physiological Assessment of Emphysema in Mouse Lung.2013
- Author(s)
  井口智史、木村敦臣
- Journal Title
  
  Magn. Reson. Med.
  
  Volume: in press Issue: 1 Pages: 592-600
- DOI
  10.1002/mrm.24452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500408, KAKENHI-PROJECT-23700534, KAKENHI-PROJECT-24300163
[Journal Article] Validation of non-invasive morphological and diffusion imaging in mouse emphysema by micro-CT and hyperpolarized ^129Xe MRI2013
- Author(s)
  Satoshi Tetsumoto, Yoshioto Takeda, Hirohiko Imai, et al.
- Journal Title
  
  Am J Respir Cell Mol Biol
  
  Volume: 掲載決定 Issue: 4 Pages: 592-600
- DOI
  10.1165/rcmb.2012-0350oc
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700534, KAKENHI-PROJECT-24300163, KAKENHI-PROJECT-25461386
[Journal Article] Direct Imaging of Alveolar Gas Uptake with Hyperpolarized ^<129>xe Ultra-short Echo-Time MR1 and Its Application to Physiological Assessment of Emphysema in Mouse Lung.2013
- Author(s)
  井口智史、木村敦臣
- Journal Title
  
  Magn. Reson. Med.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24300163
[Journal Article] Development of a fast method for quantitative measurement of hyperpolarized ^129Xe dynamics in mouse brain2012
- Author(s)
  Hirohiko Imai, et al.
- Journal Title
  
  NMR Biomed
  
  Volume: 25巻 Issue: 2 Pages: 210-217
- DOI
  10.1002/nbm.1733
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700534, KAKENHI-PROJECT-24300163
[Journal Article] Development of a Fast Method for Quantitative Measurement of Hyperpolarized ^129Xe Dynamics in Mouse Brain.2012
- Author(s)
  Imai H, Kimura A, Akiyama K, Ota C, Okimoto K, Fujiwara H.
- Journal Title
  
  NMR Biomed
  
  Volume: 25 Pages: 210-217
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500408
[Journal Article] Development of a Fast Method for Quantitative Measurement of Hyperpolarized 129xe Dynamics in Mouse Brain.2012
- Author(s)
  今井宏彦、木村敦臣
- Journal Title
  
  NMR Biomed
  
  Volume: 25 Pages: 210-217
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500408
[Journal Article] Hyperpolarized ^129Xe Lung MRI in Spontaneous Breathing Mice with Respiratory Gated Fast Imaging and Its Application to Pulmonary Functional Imaging.2011
- Author(s)
  Imai H, Kimura A, Hori Y, Iguchi S, Kitao T, Okubo E, Ito T, Matsuzaki T, Fujiwara H.
- Journal Title
  
  NMR Biomed
  
  Volume: 24 Pages: 1-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500408
[Journal Article] Hyperpolarized ^129Xe MR Imaging with Balanced Steady-State Free Precession in Spontaneously Breathing Mouse Lungs.2011
- Author(s)
  Imai F, Kashiwagi R, Imai H, Iguchi S, Kimura A, Fujiwara H.
- Journal Title
  
  Magn Reson Med Sci
  
  Volume: 10 Pages: 33-40
- NAID
  10029698048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500408
[Journal Article] Confirming the Origin of Dissolved-Phase Hyperpolarized ^129Xe Signal from the Mice Chest Based on Experimental Evidence from Extensive Magnetic Resonance Measurements.2011
- Author(s)
  Narazaki M, Kimura A, Imai H, Fujiwara H.
- Journal Title
  
  Magn Reson Med Sci
  
  Volume: 10 Pages: 149-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500408
[Journal Article] Comprehensive Pulmonary Evaluation of Emphysematous Mice Using Hyperpolarized ^<129>Xe MRI/MRS Under Spontaneous Breathing Mode2010
- Author(s)
  今井宏彦、木村敦臣
- Journal Title
  
  Proc.Intl.Soc.Mag.Reson.Med.
  
  Volume: 18 Pages: 4608-4608
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500408
[Journal Article] Hyperpolarized ^129Xe dynamic study in mouse lung under spontaneous respiration: Application to murine tumor B16BL6 melanoma.2010
- Author(s)
  Imai H, Kimura A, Ito T, Fujiwara H.
- Journal Title
  
  Eur J Radiol
  
  Volume: 73 Pages: 196-205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500408
[Journal Article] Hyperpolarized ^<129>Xe dynamic studay in mouse lung under spontaneous respiration : Application to murine tumor B16BL6 melanoma2010
- Author(s)
  今井宏彦、木村敦臣
- Journal Title
  
  Eur J Radiol
  
  Volume: 73 Pages: 196-205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500408
[Journal Article] Non-invasive Detection of Pulmonary Tissue Destruction in a Mouse Model of Emphysema Using Hyperpolarized ^129Xe MRS under Spontaneous Respiration.2010
- Author(s)
  Imai H, Kimura A, Iguchi S, Hori Y, Masuda S, Fujiwara H.
- Journal Title
  
  Magn Reson Med
  
  Volume: 64 Pages: 929-938
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500408
[Journal Article] Non-invasive Detection of Pulmonary Tissue Destruction in a Mouse Model of Emphysema Using Hyperpolarized ^<129>Xe MRS under Spontaneous2010
- Author(s)
  今井宏彦、木村敦臣
- Journal Title
  
  Magn Reson Med
  
  Volume: 64 Pages: 929-938
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500408
[Journal Article] Improvement of T_1 Determination of Hyperpolarized ^<129>Xe in Mouse Brain under Controlled-Flow2005
- Author(s)
  木村敦臣
- Journal Title
  
  Magnetic Resonance in Medical Sciences (印刷中)
- NAID
  10014455584
- Data Source
  KAKENHI-PROJECT-14770453
[Journal Article] Practical Application of NMR Spectra of ^<129>Xe dissolved in Red Blood Cell2004
- Author(s)
  Y.Kawata, T.Kamiya, H.Miura, A.Kimura, H.Fujiwara
- Journal Title
  
  International Congress Series 1265
  
  Pages: 172-176
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370277
[Journal Article] MRI and MRS of Mouse Head at 9.4T using Hyperpolarized Xenon Gas2004
- Author(s)
  T.Wakayama, T.Oose, M.Narazaki, A.Kimura, H.Fujiwara
- Journal Title
  
  International Congress Series 1265
  
  Pages: 167-171
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370277
[Journal Article] Improvement of T1 Determination of Hyperpolarized 129Xe in Mouse Brain under Controlled-2004
- Author(s)
  A.Kimura, T.Wakayama, M.Narazaki, Y.Kawata, T.Ueyama, H.Fujiwara
- Journal Title
  
  International Congress Series 1265
  
  Pages: 199-205
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370277
[Journal Article] MRS of Hypperpolarized ^<129>Xe in the Chest of Mouse - Effect of Contrast Agents on the MRS2004
- Author(s)
  M.Narazaki, T.Wakayama, A.Kimura, H.Fujiwara
- Journal Title
  
  International Congress Series 1265
  
  Pages: 177-180
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370277
[Journal Article] Hyperpolarized ^<129>Xe as a Novel Probe Agent of Lung Functions in MRI and MRS. Experimental Results with Mice at 9.4T2004
- Author(s)
  H.Fujiwara, A.Kimura, T.Wakayama
- Journal Title
  
  International Congress Series 1265
  
  Pages: 124-130
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370277
[Journal Article] Improvement of T_1 Determination of Hyperpolarized ^<129>Xe in Mouse Brain under Controlled-Flow2004
- Author(s)
  A.Kimura
- Journal Title
  
  Magn.Reson.Med.Sci 3
  
  Pages: 199-205
- NAID
  10014455584
- Data Source
  KAKENHI-PROJECT-17689037
[Journal Article] MRS of Hyperpolarized ^<129>Xe in the Chest of Mouse -Effect of Contrast Agents on the MRS2004
- Author(s)
  M.Narazaki, T.Wakayama, A.Kimura, H.Fujiwara
- Journal Title
  
  International Congress Series 1265
  
  Pages: 177-180
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370277
[Journal Article] ^<19>F Magnetic Resonance Imaging of Perfluorooctanoic Acid Encapsulated in Liposome for Biodistribution Measurement2004
- Author(s)
  A.Kimura, M.Narazaki, Y.Kanazawa, H.Fujiwara
- Journal Title
  
  Mag.Reson.Imag. 22
  
  Pages: 855-860
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370277
[Journal Article] Improvement of T1 Determination of Hyperpolarized 129Xe in Mouse Brain under Controlled- Flow2004
- Author(s)
  A.Kimura, T.Wakayama, M.Narazaki, Y.Kawata, T.Ueyama, H.Fujiwara
- Journal Title
  
  International Congress Series 1265
  
  Pages: 199-205
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370277
[Journal Article] Analysis of the Effect of Foreign Gases in the Production of Hyperpolarized 129Xe Gas on a Simple System working under Atmospheric Pressure2003
- Author(s)
  J.Fukutomi, E.Suzuki, T.Shimizu, A.Kimura, H.Fujiwara
- Journal Title
  
  J.magn.Reson. 160
  
  Pages: 26-32
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370277
[Journal Article] Analysis of the Effect of Foreign Gases in the Production of Hyperpolarized 129Xe Gas on a Simple System working under Atmospheric Pressure2003
- Author(s)
  J.Fukutani, E.Suzuki, T.Shimizu, A.Kimura, H.Fujiwara
- Journal Title
  
  J.magn.Reson. 160
  
  Pages: 26-32
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370277
[Presentation] 表面修飾酸化鉄ナノ粒子を分子造影剤として使用した超偏極129XeMRIによる肺癌イメージング2023
- Author(s)
  下出剛史、三木琴音、内海誠也、木村敦臣
- Organizer
  第51回日本磁気共鳴医学会大会
- Data Source
  KAKENHI-PROJECT-23K20411
[Presentation] 循環型超偏極キセノンガス生成供給装置を利用したナノ細孔解析．セルロースナノ　　　ファイバーについて2023
- Author(s)
  藤原英明，今井宏彦，木村敦臣
- Organizer
  第62回NMR討論会
- Data Source
  KAKENHI-PROJECT-21K18980
[Presentation] 腫瘍特異的造影剤を用いた超偏極129Xe MRIにおける肺腫瘍イメージングの基礎的検討2022
- Author(s)
  木村敦臣 , 内海誠也 , 宮岡美咲 , 森明亮我 , 今井宏彦
- Organizer
  第50回日本磁気共鳴医学会大会
- Data Source
  KAKENHI-PROJECT-23K20411
[Presentation] 造影剤を用いた超偏極 129Xe MRIにおける肺癌イメージングの基礎的検討2021
- Author(s)
  木村敦臣, 内海誠也, 宮岡美咲, 森明亮我, 谷村成起, 今井宏彦
- Organizer
  日本磁気共鳴医学会
- Data Source
  KAKENHI-PROJECT-23K20411
[Presentation] Xe-NMR Study of Zeolites. How to enhance the Reliability Adsorption Properties determined by NMR experiments2021
- Author(s)
  Hideaki Fujiwara, Hirohiko Imai, Yuko Adachi, Atsuomi Kimura
- Organizer
  22nd International Society of Magnetic Resonance Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18980
[Presentation] 超偏極129Xe MRIによるピルビン酸エチルの早期肺癌治療効果の観察2020
- Author(s)
  内海誠也, 西森廉弥, 吉田月帆, 森勇斗, 木村敦臣
- Organizer
  日本磁気共鳴医学会大会
- Data Source
  KAKENHI-PROJECT-23K20411
[Presentation] 超偏極129Xeを用いた肺がんモデルマウスに対するピルビン酸エチルの薬効評価2019
- Author(s)
  内海誠也, 吉岡佐希子, 西森廉弥, 木村敦臣
- Organizer
  第47回日本磁気共鳴医学会大会
- Data Source
  KAKENHI-PROJECT-15H03006
[Presentation] 超偏極キセノンガス生成供給装置普及版の作成と応用2018
- Author(s)
  藤原英明, 今井宏彦, 木村敦臣
- Organizer
  第57回NMR討論会
- Data Source
  KAKENHI-PROJECT-15H03006
[Presentation] Multiplexed HyperCEST detection of genetically-reconstituted gas vesicle nanoparticles in human cancer cells in vitro.2018
- Author(s)
  水島良太, 井上加奈子, 永井里奈, 岩根敦子, 渡邊朋信, 木村敦臣
- Organizer
  第57回NMR討論会
- Data Source
  KAKENHI-PROJECT-15H03006
[Presentation] Quantitative evaluation of magnetic nanoparticle distribution in murine brain using magnetic particle imaging2017
- Author(s)
  Inaoka Y, Hosoi R, Kimura A, Murase K
- Organizer
  39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25282131
[Presentation] Continuous-Flow Type Production of Hyperpolarized 129Xe and Its Application to Preclinical MRI2017
- Author(s)
  木村敦臣
- Organizer
  大阪大学蛋白質研究所セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-15H03006
[Presentation] Relationship between Brain and Pulmonary Function Studied by Hyperpolarized 129Xe MRI/MRS2016
- Author(s)
  Akihiro Shimkawa, Hironobu Matsumoto, Yukiko Yamauchi, Shota Hodono, Shintaro Okumura, Neil J Stewart, Hirohiko Imai, Hideaki Fujiwara, Atsuomi Kimura.
- Organizer
  1st AOWPFI & 8th JSPFI
- Place of Presentation
  Awaji Yumebutai International Conference Center、兵庫県(洲本市)
- Year and Date
  2016-01-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24300163
[Presentation] Evaluation of Drug Efficacy of Ethyl Pyruvate on the Emphysema in Mice by Means of Hyperpolarized 129Xe MRI2016
- Author(s)
  Akihiro Shimokawa, Shota Hodono, Neil J. Stewart, Hikari Ueda, Yuya Noda, Atsuomi Kimura
- Organizer
  ICMRBS2016
- Place of Presentation
  International Conference Center Kyoto（Kyoto）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03006
[Presentation] Evaluation of Drug Efficacy of Ethyl Pyruvate on the Pulmonary fibrosis in mice with Hyperpolarized 129Xe MRI Pulmonary Functional Diagnosis2016
- Author(s)
  Shota Hodono, Akihiro Shimkawa, Hideaki Fujiwara, Hirohiko Imai, Atsuomi Kimura.
- Organizer
  1st AOWPFI & 8th JSPFI
- Place of Presentation
  Awaji Yumebutai International Conference Center、兵庫県(洲本市)
- Year and Date
  2016-01-31
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24300163
[Presentation] Relationship between Brain and Pulmonary Function Studied by Hyperpolarized 129Xe MRI/MRS2016
- Author(s)
  Akihiro Shimkawa, Hironobu Matsumoto, Yukiko Yamauchi, Shota Hodono, Shintaro Okumura, Neil J Stewart, Hirohiko Imai, Hideaki Fujiwara, Atsuomi Kimura.
- Organizer
  1st AOWPFI & 8th JSPFI
- Place of Presentation
  Awaji Yumebutai International Conference Center、兵庫県(洲本市)
- Year and Date
  2016-01-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03006
[Presentation] Pulmonary Functional Imaging Using Quasi-Completely Hyperpolarized 129Xe MRI2016
- Author(s)
  Atsuomi Kimura, Akihiro Shimokawa, Shota Hodono, Yu Ozaki, Naoto Miyazaki, Hirohiko Imai, Hideaki Fujiwara
- Organizer
  ICMRBS2016
- Place of Presentation
  International Conference Center Kyoto（Kyoto）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03006
[Presentation] Evaluation of Drug Efficacy of Ethyl Pyruvate on the Pulmonary fibrosis in mice with Hyperpolarized 129Xe MRI Pulmonary Functional Diagnosis2016
- Author(s)
  Shota Hodono, Akihiro Shimkawa, Hideaki Fujiwara, Hirohiko Imai, Atsuomi Kimura.
- Organizer
  1st AOWPFI & 8th JSPFI
- Place of Presentation
  Awaji Yumebutai International Conference Center、兵庫県(洲本市)
- Year and Date
  2016-01-31
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03006
[Presentation] 高沸点ガスのクエンチング効果による超偏極129Xe MRIの高感度化と応用2013
- Author(s)
  木村　敦臣, 河村　綾乃, 内山　知香, 奥村　慎太郎, 松本　浩伸, 山内　紬起子, 藤原　英明
- Organizer
  第52回NMR討論会
- Place of Presentation
  石川県立音楽堂
- Data Source
  KAKENHI-PROJECT-24300163
[Presentation] 超偏極129Xe MRI/MRSを用いた肺・脳機能同時測定2012
- Author(s)
  松本浩伸、宮越友梨佳、奥村慎太郎、今井宏彦、藤原英明、木村敦叺
- Organizer
  第40回日本磁気共鳴医学会大会
- Place of Presentation
  国立京都国際会議場
- Year and Date
  2012-09-07
- Data Source
  KAKENHI-PROJECT-21500408
[Presentation] 超偏極希ガスのMRI/MRSによる肺機能診断法の開発2012
- Author(s)
  木村敦臣
- Organizer
  第40回日本磁気共鳴医学会大会
- Place of Presentation
  国立京都国際会議場(招待講演)
- Year and Date
  2012-09-07
- Data Source
  KAKENHI-PROJECT-24300163
[Presentation] 超偏極^129Xe MRI/MRSを用いた肺・脳機能同時測定.2012
- Author(s)
  松本浩伸、宮越友梨佳、奥村慎太郎、今井宏彦、藤原英明、木村敦臣.
- Organizer
  第40回日本磁気共鳴医学会大会
- Place of Presentation
  国立京都国際会議場
- Year and Date
  2012-09-07
- Data Source
  KAKENHI-PROJECT-21500408
[Presentation] 超偏極希ガスのMRI/MRSによる肺機能診断法の開発2012
- Author(s)
  木村敦臣
- Organizer
  第40回日本磁気共鳴医学会大会
- Place of Presentation
  国立京都国際会議場
- Year and Date
  2012-09-07
- Data Source
  KAKENHI-PROJECT-21500408
[Presentation] 超偏極希ガスのMRI/MRSによる肺機能診断法の開発.2012
- Author(s)
  木村敦臣
- Organizer
  第40回日本磁気共鳴医学会大会
- Place of Presentation
  国立京都国際会議場
- Year and Date
  2012-09-07
- Data Source
  KAKENHI-PROJECT-21500408
[Presentation] 前臨床薬効評価へ向けた肺機能MRI2009
- Author(s)
  木村敦臣
- Organizer
  日本生物工学会
- Place of Presentation
  名古屋大学 (愛知県)
- Year and Date
  2009-09-25
- Data Source
  KAKENHI-PROJECT-21500408
[Presentation] 高沸点ガスのクエンチ効果を用いた超偏極129Xe MRIの高感度化と応用
- Author(s)
  程野祥太、山内紬起子、萩原祐、細川尚武、藤原英明、木村敦臣
- Organizer
  第42回日本磁気共鳴医学会大会
- Place of Presentation
  ホテルグランヴィア京都（京都府京都市）
- Year and Date
  2014-09-18 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-24300163
[Presentation] 超偏極129Xe MRI/MRSによる脳・肺機能連関に関する研究
- Author(s)
  山内紬起子、松本浩伸、程野祥太、萩原祐、細川尚武、藤原英明、木村敦臣
- Organizer
  第42回日本磁気共鳴医学会大会
- Place of Presentation
  ホテルグランヴィア京都（京都府京都市）
- Year and Date
  2014-09-18 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-24300163
[Presentation] 温度感受性リポソームを用いたCEST MRI用プローブによる化学シフトの制御に関する検討
- Author(s)
  丸山修紀, 木村敦臣, 上田淳平, 齋藤茂芳, 村瀬研也
- Organizer
  第42回日本磁気共鳴医学会大会
- Place of Presentation
  京都
- Year and Date
  2014-09-18 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-25670532

1. FUJIWARA Hideaki (90107102)

# of Collaborated Projects: 5 results

# of Collaborated Products: 27 results
2. Kenya Murase (50157773)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
3. YOSHIOKA Yoshichika (00174897)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. TAKATA Hiroshige

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TAKEUCHI Tomoki

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. TAKEDA Yoshito (40452388)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. IMAI Hirohiko (40506466)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
8. 杉浦眞喜子 (00098500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 岩崎智宏 (50295721)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 白土優 (70379121)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 近江雅人 (60273645)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. UEDA Junpei

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. SASAHARA Hisato

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. YABATA Isamu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 鎌田佳宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 渡邉朋信

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KIMURA Atsuomi 木村 敦臣

Research Projects

Research Products

Co-Researchers

Enhancement of robustness and sustainability of hyperpolarized xenon NMR and novel establishments as a fundamental technology for the development of new materialsPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

ナノメディスンと超偏極希ガスMRIの融合による超高感度肺癌検出システムの開発Principal Investigator

Principal Investigator

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Review Section

Research Institution

Development of a system for optimizing magnetic targeting and magnetic hyperthermia treatment using newly-developed magnetic particle imaging

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Research Institution

Development and application of an innovative pulmonary functional diagnostic system using hyperpolarized noble gas MRI aiming at complete polarizationPrincipal Investigator

Principal Investigator

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Research Institution

Establishment of elemental techniques for magnetic particle imaging aiming at application to nanoparticle medicine

Principal Investigator

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Development of a new method for quantifying chemical exchange rate and visualizing pH using CEST MRI

Principal Investigator

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Development of preclinical system based on pulmonary functional imaging by hyperpolarized Xe MRIPrincipal Investigator

Principal Investigator

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Research Institution

Development andApplication of Methodology of Magnetic Resonance Measurement of Hyperpolarized Noble Gas Contributable to Physiological Diagnosis.Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

超偏極希ガスのMRI/MRSによる新規肺機能診断法の開発に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

簡易連続型超偏極希ガス生成装置の試作と水素や炭素核の高感度MRI実験への応用

Principal Investigator

Project Period (FY)

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Research Institution

超偏極希ガスの連続フロー型製造装置開発と脳機能磁気共鳴研究への応用Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Applied Clinical Study on Hyperpolarized Noble Gas MRI/MRS using Pathologic Model Animal

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

液晶NMR法におけるキラル液晶系の利用と天然分子の絶対構造決定の開発

Principal Investigator

Project Period (FY)

Research Category

KIMURA Atsuomi 木村敦臣