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Shimizu Takeshi  清水 健

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… Alternative Names

清水 健  シミズ タケシ

SHIMIZU Takeshi  清水 健

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Researcher Number 70312840
Other IDs
Affiliation (Current) 2022: 千葉大学, 大学院医学研究院, 准教授
Affiliation (based on the past Project Information) *help 2020 – 2021: 千葉大学, 大学院医学研究院, 准教授
2016 – 2018: 千葉大学, 大学院医学研究院, 准教授
2013 – 2016: 千葉大学, 医学(系)研究科(研究院), 准教授
2010 – 2012: 千葉大学, 大学院・医学研究院, 准教授
2006 – 2009: 千葉大学, 大学院・医学研究院, 講師 … More
2006: Chiba University, Graducate School of Medicine, Assistant Professor, 大学院医学研究院, 講師
2005: 筑波大学, 大学院・人間総合科学研究科, 講師
2003: 筑波大, 基礎医学系, 講師
2000 – 2001: 筑波大学, 基礎医学系, 講師 Less
Review Section/Research Field
Principal Investigator
Bacteriology (including Mycology) / Bacteriology (including mycology) / Bacteriology (including Mycology) / Biological Sciences / Basic Section 49050:Bacteriology-related
Except Principal Investigator
Bacteriology (including Mycology) / Biological Sciences / Digestive surgery
Keywords
Principal Investigator
腸管出血性大腸菌 / 病原性 / 分泌 / 感染症 / 細菌 / 細菌毒素 / 志賀様毒素 / 志賀毒素 / Gb3 / 一酸化窒素 … More / NO消去酵素 / NO還元酵素 / プロテオーム解析 / ウェルシュ菌 / 2次元電気泳動 / 質量分析 / プロティアーゼ / 病原因子 / 2成分制御系 / MALDI-TOFMS / ポストゲノム / 最近 / 毒素産生 / NO / NO reductase / 遺伝子発現 / 嫌気状態 / 活性酸素種 / 増殖性 / 抗菌薬 / 嫌気条件 / 宿主防御機構 / 動物実験 / 嫌気性 / 薬剤耐性 / 細菌感染症 / Enterohemorrhagic Escherichia coli / Shiga toxins / Secretion / Virulence / Bacterial infection / 一酸化窒素還元酵素 / NOセンサー / 重症化 / O157 / 生体防御機構抵抗因子 / EHEC / 一酸化窒素(NO) … More
Except Principal Investigator
SubAB / 一酸化窒素 / 毒素 / 腸管出血性大腸菌 / 志賀毒素 / EHEC / Stx / AB成分毒素ファミリー / STEC / 0157 / O157 / S-ニトロシル化 / S-ニトロソシステイン / シグナル伝達 / 細胞間情報伝達 / ニトロソシステイン代謝酵素 / ニトロソストレス / 神経変性疾患 / S-ニトロシル化 / Sーニトロソシステイン / 細胞間伝達 / ニトロシル化 / 翻訳後修飾 / トランスポーター / 活性酸素 / ニトロソ化 / 細胞膜 / オルガネラ / ER ストレス / アポトーシス / 受容体 / サブチラーゼサイトトキシン / BiP / ERストレス / Bcl-2 / 小胞体ストレス / 細胞死 / ストレスグラニュール / 酸化ストレス / lipid-raft / オートファジー / 取り込み機構 / 阻害剤 / lipid-raft / NO / 大腸癌 / ADP-リボシル化 / 蛋白質 / 外科 / ADP-リポシル化 / colorectal cancer / adenosine 5' -diphosphate (ADP)-ribosylation / protein / surgery Less
  • Research Projects

    (13 results)
  • Research Products

    (114 results)
  • Co-Researchers

    (22 People)
  •  腸管出血性大腸菌特異的な生体防御機構抵抗因子の同定と機能解析Principal Investigator

    • Principal Investigator
      清水 健
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49050:Bacteriology-related
    • Research Institution
      Chiba University
  •  A study on the acquisition mechanism of pathogenicity in intact NO reductase-type EHECPrincipal Investigator

    • Principal Investigator
      Shimizu Takeshi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bacteriology (including mycology)
    • Research Institution
      Chiba University
  •  Establishment of absolute anaerobic biology for pathogenic evaluation of EHECPrincipal Investigator

    • Principal Investigator
      Shimizu Takeshi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Bacteriology (including mycology)
    • Research Institution
      Chiba University
  •  Elucidation of the pathogenic reinforcement action of enterohemorrhagic Escherichia coli produced SubAB

    • Principal Investigator
      Noda Masatoshi
    • Project Period (FY)
      2012 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Chiba University
  •  Elucidation of Shiga-toxigenic Escherichia coli produced Subtilase cytotoxin-induced cell damage mechanism.

    • Principal Investigator
      NODA Masatoshi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Chiba University
  •  Study of Shiga toxin productions us ing in vivo analysisPrincipal Investigator

    • Principal Investigator
      SHIMIZU Takeshi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Chiba University
  •  Explication of the regulatory mechanism of S-nitrosylation signaling

    • Principal Investigator
      MATSUMOTO Akio
    • Project Period (FY)
      2008 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Chiba University
      Osaka University
  •  Studies on the SubAB toxin, its target organs, and its quick identification

    • Principal Investigator
      NODA Masatoshi
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Chiba University
  •  Analysis of secretion system of virulence factor in gram-negative bacteriaPrincipal Investigator

    • Principal Investigator
      SHIMIZU Takeshi
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Chiba University
  •  Elucidation of a potential role of poly-ADP-ribosylation in the carcinogenesis or development of human colorectal carcinoma and its application for the diagnosis or trteatment of human colorectal carcinoma

    • Principal Investigator
      NABEYA Yoshihiro
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Chiba University
  •  Study on the virulence factors of enterohemorrhagic Escherichia coliPrincipal Investigator

    • Principal Investigator
      SHIMIZU Takeshi
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Chiba University
      University of Tsukuba
  •  病原細菌における病原因子の機能的検索法の開発Principal Investigator

    • Principal Investigator
      清水 健
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      University of Tsukuba
  •  ポストゲノムプロジェクトにおけるプロテオーム解析Principal Investigator

    • Principal Investigator
      清水 健
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      University of Tsukuba

All 2022 2021 2020 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Patent

  • [Journal Article] Enhanced production of Shiga toxin 1 in enterohaemorrhagic Escherichia coli by oxygen2021

    • Author(s)
      Shimizu Takeshi、Onuki Manami、Suzuki Shin、Hirai Shinichiro、Yokoyama Eiji、Matsumoto Akio、Hamabata Takashi
    • Journal Title

      Microbiology

      Volume: 167 Pages: 1-11

    • DOI

      10.1099/mic.0.001122

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07474
  • [Journal Article] Effect of Sub-MICs of Macrolides on the Sensitivity ofPseudomonas aeruginosato Nitrosative Stress: Effectiveness againstP. aeruginosawith and without Multidrug Resistance2020

    • Author(s)
      Takeshi Shimizu, Tohru Miyoshi-Akiyama, Kohei Ogura, Shota Murata, Shota Ishige, Kiyohiro Kai, Konosuke Mitsutsuka, Haruyoshi Tomita, Koichi Tanimoto, and Akio Matsumoto
    • Journal Title

      Antimicrobial Agents and Chemotherapy

      Volume: 64

    • DOI

      10.1128/aac.01180-20

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07474, KAKENHI-PROJECT-18K07133
  • [Journal Article] Mechanism of inhibition of Shiga-toxigenic Escherichia coli SubAB cytotoxicity by steroids and diacylglycerol analogues.2018

    • Author(s)
      Yahiro Kinnosuke、Nagasawa Sayaka、Ichimura Kimitoshi、Takeuchi Hiroki、Ogura Kohei、Tsutsuki Hiroyasu、Shimizu Takeshi、Iyoda Sunao、Ohnishi Makoto、Iwase Hirotaro、Moss Joel、Noda Masatoshi
    • Journal Title

      Cell Death Discovery

      Volume: 4 Pages: 1-13

    • DOI

      10.1038/s41420-017-0007-4

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08486, KAKENHI-PROJECT-16K08770, KAKENHI-PROJECT-17K10019, KAKENHI-PROJECT-18K07133, KAKENHI-PROJECT-16K08771
  • [Journal Article] Nitric oxide-enhanced Shiga toxin production was regulated by Fur and RecA in enterohemorrhagic Escherichia coli O1572017

    • Author(s)
      K. Ichimura, Shimizu. T, Takeuchi. H, Matsumoto. A, Yahiro. K, Noda. M,
    • Journal Title

      Microbiology Open

      Volume: 印刷中 Pages: 1-17

    • DOI

      10.1002/mbo3.461

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390104, KAKENHI-PROJECT-26670208, KAKENHI-PROJECT-16K08771, KAKENHI-PROJECT-16K15315, KAKENHI-PROJECT-16K08770
  • [Journal Article] The surface sensor NlpE of enterohemorrhagic Escherichia coli contributes to regulation of the type III secretion system and flagella by the Cpx response to adhesion.2016

    • Author(s)
      Takeshi Shimizu, Kimitoshi Ichimura and Masatoshi Noda
    • Journal Title

      Infect. Immun.

      Volume: 84 Pages: 537-549

    • DOI

      10.1128/iai.00881-15

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670208, KAKENHI-PROJECT-24390104
  • [Journal Article] An evolutionary analysis of nitric oxide reductase gene norV in enterohemorrhagic Escherichia coli O1572015

    • Author(s)
      Takeshi Shimizu, Shinichiro Hirai, Eiji Yokoyama, Kimitoshi Ichimura and Masatoshi Noda
    • Journal Title

      Infection, Genetics and Evolution

      Volume: 印刷中

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26670208
  • [Journal Article] An evolutionary analysis of nitric oxide reductase gene norV in enterohemorrhagic Escherichia coli O1572015

    • Author(s)
      Takeshi Shimizu, Shinichiro Hirai, Eiji Yokoyama, Kimitoshi Ichimura and Masatoshi Noda
    • Journal Title

      Infect. Genet. Evol.

      Volume: 33 Pages: 176-181

    • DOI

      10.1016/j.meegid.2015.04.027

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670208
  • [Journal Article] 腸管出血性大腸菌による食中毒重症化メカニズム2013

    • Author(s)
      清水 健、野田 公俊
    • Journal Title

      日本医事新報

      Volume: 4614 Pages: 98-99

    • Data Source
      KAKENHI-PROJECT-24390104
  • [Journal Article] Large - scale preparation of Shiga toxin 2 1n Escherichia coli for toxoid vaccine antigen production.2013

    • Author(s)
      Hideyuki Arimitsu, Keiko Sasaki, Takeshi Shimizu, Kentaro Tsukamoto, Toshiyasu Shimizu and Takao Tsuji
    • Journal Title

      Microbiol. Immunol.

      Volume: 57 Pages: 38-45

    • DOI

      10.1111/j.1348-0421.2012.12004.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390104
  • [Journal Article] Large-scale preparation of Shiga toxin 2 in Escherichia coli for toxoid vaccine antigen production2013

    • Author(s)
      Hideyuki Arimitsu, Keiko Sasaki, Takeshi Shimizu, Kentaro Tsukamoto,
    • Journal Title

      Microbiol. Immunol.

      Volume: 57 Pages: 38-45

    • NAID

      40019554365

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390104
  • [Journal Article] 腸管出血性大腸菌の重症化要因2013

    • Author(s)
      清水 健、野田 公俊
    • Journal Title

      感染・炎症・免疫

      Volume: 43 Pages: 74-76

    • Data Source
      KAKENHI-PROJECT-24390104
  • [Journal Article] Proteomic analysis of S-nitrosylation induced by 1-methyl-4-henylpyridinium (MPP+)2012

    • Author(s)
      Komatsubara A. T.,Asano T.,Tsumoto H., Shimizu K.,Nishiuchi T.,Yoshizumi M., Ozawa K
    • Journal Title

      Proteome Sci.

      Volume: 10 Pages: 74-80

    • DOI

      10.1186/1477-5956-10-74

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20117008, KAKENHI-PROJECT-23590306
  • [Journal Article] Proteomic analysis of the role of S-nitrosoglutathione reductase in lipopolysaccharide-challenged mice.2012

    • Author(s)
      0zawa K.,Tsumoto H.,Wei W.,Tang C. H., Konlatsubara A. T.,Kawafune H.,Shimizu K., Liu L., Tsujimoto G
    • Journal Title

      Proteomics

      Volume: 12 Pages: 2024-2035

    • DOI

      10.1002/pmic.201100666

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20117008
  • [Journal Article] 腸管出血性大腸菌による食中毒重症化メカニズム2012

    • Author(s)
      清水 健、野田公俊
    • Journal Title

      日本医事新報

      Volume: 4614 Pages: 98-99

    • Data Source
      KAKENHI-PROJECT-24390104
  • [Journal Article] Recombinant Shiga toxin B subunit can induce neutralizing immunoglobulin Y antibody.2012

    • Author(s)
      Paola Neri, Shunji Tokoro, Tsuyoshi Sugiyama, Kouji Umeda, Takeshi Shimizu, Takao Tsuji, Yoshikatsu Kodama and Hiroshi Mori
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 35 Pages: 917-923

    • NAID

      130001872174

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390104
  • [Journal Article] Recombinant Shiga toxin B subunit can induce neutralizing IgY antibody2012

    • Author(s)
      Paola Neri, Shunji Tokoro, Tsuyoshi Sugiyama, Kouji Umeda, Takeshi Shimizu, Takao Tsuji, Yoshikatsu Kodama, Hiroshi Mori
    • Journal Title

      Biol.Pharm.Bull.

      Volume: (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590478
  • [Journal Article] Specific Egg Yolk Immunoglobulin as a New Preventive Approach for Shiga-Toxin-Mediated Diseases2012

    • Author(s)
      Paola Neri, Shunji Tokoro, Ryo Kobayashi, Tsuyoshi Sugiyama, Kouji Umeda, Takeshi Shimizu, Takao Tsuji, Yoshikatsu Kodama, Keiji Oguma Hiroshi Mori
    • Journal Title

      PLoS ONE

      Volume: 6(10)

    • DOI

      10.1371/journal.pone.0026526

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590478, KAKENHI-PROJECT-21590497
  • [Journal Article] Subtilase cytotoxin enhances E. coli survival in macrophages by suppression of nitric oxide production through the inhibition of NF-kappaB activation.2012

    • Author(s)
      Tsutsuki H, Yahiro K, Suzuki K, Suto A, Ogura K, Nagasawa S, Ihara H, Shimizu T, Nakajima H, Moss J, Noda M
    • Journal Title

      Infect Immun

      Volume: 80 Pages: 3939-51

    • DOI

      10.1128/iai.00581-12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591432, KAKENHI-PROJECT-23591458, KAKENHI-PROJECT-24390104
  • [Journal Article] Characterization of intracellular localization of PrPSc in prion-infected cells using monoclonal antibody that recognizes the region consisting of aminoacids 119-127 of mouse PrP2012

    • Author(s)
      Yamasaki T., Suzuki A., Shimizu T., Watarai M., Hasebe R., Horiuchi M.
    • Journal Title

      J Gen Virol

      Volume: vol.93 no.3 Pages: 668-680

    • DOI

      10.1099/vir.0.037101-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J04181, KAKENHI-PROJECT-21590478, KAKENHI-PROJECT-23248050, KAKENHI-PROJECT-23658233, KAKENHI-PROJECT-23780303
  • [Journal Article] The nitric oxide reductase of enterohaemorrhagic Escherichia coli plays an important role for the survival within macrophages.2012

    • Author(s)
      Shimizu T, Tsutsuki H, Matsumoto A, Nakaya H, Noda M
    • Journal Title

      Mol. Microbiol.

      Volume: 85 Pages: 492-512

    • DOI

      10.1111/j.1365-2958.2012.08122.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20117008, KAKENHI-PROJECT-23390053, KAKENHI-PROJECT-24390104, KAKENHI-PROJECT-24659111
  • [Journal Article] Construction of a novel bioluminescent reporter system for investigating Shiga toxin expression of enterohaemorrhagic.Escbericbia coli2011

    • Author(s)
      Takeshi Shimizu
    • Journal Title

      Gene

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590478
  • [Journal Article] Construction of a novel bioluminescent reportersystem for investigating Shiga toxin expression of enterohaemorrhagic2011

    • Author(s)
      Takeshi Shimizu, Yuko Ohta, Hiroyasu Tsutsuki Masatoshi Noda
    • Journal Title

      Escherichia coli. Gene

      Volume: 478 Pages: 1-10

    • DOI

      10.1016/j.gene.2011.01.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590478
  • [Journal Article] Shiga toxin 2 is specifically released from bacterial cells by two different mechanisms2009

    • Author(s)
      Takeshi Shimizu, Yuko Ohta and Masatoshi Noda
    • Journal Title

      Infect.Immun. (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590440
  • [Journal Article] Differential entry of Botulinum neurotoxin A into neural and intestinal cells2009

    • Author(s)
      Aurelie Couesnon, Takeshi Shimizu and Michel R. Popoff
    • Journal Title

      Cell. Microbiol. 11

      Pages: 289-308

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590440
  • [Journal Article] Shiga toxin 2 is specifically released from bacterial cells by two different mechanisms.2009

    • Author(s)
      Takeshi Shimizu
    • Journal Title

      Infect.Immun. 77

      Pages: 2813-2823

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590478
  • [Journal Article] Shiga toxin 2 is specifically released from bacterial cells by two different mechanisms2009

    • Author(s)
      Takeshi Shimizu, Yuko Ohta Masatoshi Noda,
    • Journal Title

      Infect. Immun

      Volume: 77 Pages: 2813-2823

    • DOI

      10.1128/iai.00060-09

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590478
  • [Journal Article] Differential entry of Botulinum neurotoxin A into neural andintestinal cells2009

    • Author(s)
      Aurelie Couesnon, Takeshi Shimizu Michel R. Popoff
    • Journal Title

      Cell. Microbiol

      Volume: 11 Pages: 289-308

    • DOI

      10.1111/j.1462-5822.2008.01253.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590478
  • [Journal Article] A nasal vaccine comprising B-subunit derivative of Shiga toxin 2 for cross-protection aganst Shiga toxin types 1 and 22008

    • Author(s)
      Takao Tsuji, Takeshi Shimizu, Keiko Sasaki, Kentaro Tsukamoto, Hideyuki Arimitsu, Sadayuki Ochi, Toshiyasu Shimizu, Koki Taniguchi, Masatoshi Noda, Paola Neri, Hiroshi Mori
    • Journal Title

      Vaccine 26

      Pages: 2092-2099

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590440
  • [Journal Article] Protection of mice from Shiga toxin-2 toxemia by mucosal vaccine of Shiga toxin 2B-His with Escherichia coli enterotoxin2008

    • Author(s)
      Takao Tsuji, Takeshi Shimizu, Keiko Sasaki, Toshiyasu Shimizu, Kentaro Tsukamoto, Hideyuki Arimitsu, Sadayuki Ochi, Satoshi Sugiyama, Koki Taniguchi, Paola Neri, Hiroshi Mori
    • Journal Title

      Vaccine 26

      Pages: 469-476

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590440
  • [Journal Article] Serine 31 residue of B subunit of Shiga toxin 2 is essential for the secretion in Enterohemorrhagic Escherichia coli2007

    • Author(s)
      Takeshi Shimizu
    • Journal Title

      Infect. Immun 75

      Pages: 2189-2200

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590440
  • [Journal Article] Serine 31 residue of B subunit of Shiga toxin 2 is essentia for the secretion in Enterohemorrhagic Escherichia coli.2007

    • Author(s)
      Takeshi Shimizu
    • Journal Title

      Infection and Immunity (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590382
  • [Journal Article] Serine 31 residue of B subunit of Shiga toxin 2 is essential for thsecretion in Enterohemorrhagic Escherichia coli.2007

    • Author(s)
      Takeshi Shimizu
    • Journal Title

      Infection and Immunity in press

    • Data Source
      KAKENHI-PROJECT-17590382
  • [Journal Article] Receptor affinity, stability and binding mode of Shiga toxins are determinants of toxicity2007

    • Author(s)
      Takeshi Shimizu, Toshio Sato, Satomi Kawakami, Toshiko Ohta, Masatoshi Noda and Takashi Hamabata
    • Journal Title

      Microb. Pathog. 43

      Pages: 88-95

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590440
  • [Journal Article] Serine 31 residue of B subunit of Shiga toxin 2 is essential for the secretion in Enterohemorrhagic Escherichia coli2007

    • Author(s)
      Takeshi Shimizu, Satomi Kawakami, Toshio Sato, Terumi Sasaki, Masato Higashide, Takashi Hamabata, Toshiko Ohta and Masatoshi Noda
    • Journal Title

      Infect. Immun. 75

      Pages: 2189-2200

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590440
  • [Journal Article] Receptor affinity, stability and binding mode of Shliga toxins are determinants of toxicity2007

    • Author(s)
      Takeshi Shimizu
    • Journal Title

      Microb. Pathog 43

      Pages: 88-95

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590440
  • [Journal Article] Serine 31 residue of B subunit of Shiga toxin 2 is essential for the secretion in Enterohemorrhagic Escherichia coli

    • Author(s)
      Takeshi Shimizu
    • Journal Title

      Infection and Immunity (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590382
  • [Journal Article] Yoshikatsu Kodama and Hiroshi Mori, 2012. Recombinant Shiga toxin B subunit can induce neutralizing IgY antibody

    • Author(s)
      Paola Neri, Shunji Tokoro, Tsuyoshi Sugiyama, Kouji Umeda, Takeshi Shimizu, Takao Tsuji
    • Journal Title

      Pharm. Bull

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590478
  • [Patent] 組換えベクター、該ベクターで形質転換された微生物を利用した一酸化窒素消去を抑制する化合物のスクリーニング方法及び細胞内一酸化窒素濃度の測定方法2016

    • Inventor(s)
      松本明郎、清水 健、野田 公俊
    • Industrial Property Rights Holder
      松本明郎、清水 健、野田 公俊
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-114134
    • Filing Date
      2016-06-08
    • Data Source
      KAKENHI-PROJECT-16K08771
  • [Patent] -酸化窒素を探知するための形質転換用組換えベクター、およびこれを用いた一酸化窒素センサ細胞2011

    • Inventor(s)
      清水健, 津々木博康, 野田公俊
    • Industrial Property Rights Holder
      国立大学法人, 千葉大学
    • Industrial Property Number
      2011-101623
    • Filing Date
      2011-04-28
    • Data Source
      KAKENHI-PROJECT-21390127
  • [Patent] 一酸化窒素を探知するための形質転換用組換えベクター、およびこれを用いた一酸化窒素センサ細胞2011

    • Inventor(s)
      清水健, 津々木博康, 野田公俊
    • Industrial Property Rights Holder
      国立大学法人千葉大学
    • Industrial Property Number
      2011-101623
    • Filing Date
      2011-04-28
    • Data Source
      KAKENHI-PROJECT-21590478
  • [Presentation] Enhanced production of Shiga toxin 2 in enterohemorrhagic Escherichia coli by oxygen2022

    • Author(s)
      Takeshi Shimizu, Manami Onuki, Shinichiro Hirai, Eiji Yokoyama, Akio Matsumoto and Takashi Hamabata
    • Organizer
      第95回 日本細菌学会総会
    • Data Source
      KAKENHI-PROJECT-20K07474
  • [Presentation] 腸管出血性大腸菌の志賀毒素産生における酸素の影響2021

    • Author(s)
      清水 健、大貫真奈美、松本明郎、濱端 崇
    • Organizer
      第94回 日本細菌学会総会
    • Data Source
      KAKENHI-PROJECT-20K07474
  • [Presentation] 志賀毒素産生とNO還元酵素2018

    • Author(s)
      清水健
    • Organizer
      第101回 日本細菌学会関東支部総会 シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K08771
  • [Presentation] Cooperative roles of NO-metabolizing enzymes in enterohemorrhagic Escherichia coli against nitrosative stress2018

    • Author(s)
      Takeshi Shimizu, Akio Matsumoto and Masatoshi Noda
    • Organizer
      52th Joint Conference on Cholera and Other Bacterial Enteric Infections Panel
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08771
  • [Presentation] 腸管出血性大腸菌の菌体内NO濃度を減少させるNO代謝酵素群の協調的な役割2018

    • Author(s)
      清水健、松本明郎、野田公俊
    • Organizer
      第91回 日本細菌学会総会
    • Data Source
      KAKENHI-PROJECT-16K08771
  • [Presentation] An evolutionary analysis of a novel virulence gene norV in enterohemorrhagic Escherichia coli O1572018

    • Author(s)
      Takeshi Shimizu, Shinichiro Hirai, Eiji Yokoyama, Kimitoshi Ichimura and Masatoshi Noda
    • Organizer
      The 7th Global Network Forum on Infection and Immunity
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08771
  • [Presentation] in vivo解析による腸管内での志賀毒素産生様式の解明2017

    • Author(s)
      清水健、松本明郎、野田公俊
    • Organizer
      第21回腸管出血性大腸菌感染症研究会
    • Data Source
      KAKENHI-PROJECT-16K08771
  • [Presentation] Role of NO-metabolizing enzymes in enterohemorrahgic Escherichia coli under NO stress conditions2017

    • Author(s)
      Takeshi Shimizu, Akio Matsumoto and Masatoshi Noda
    • Organizer
      日本細菌学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-19
    • Data Source
      KAKENHI-PROJECT-26670208
  • [Presentation] NOストレス環境における腸管出血性大腸菌のNO代謝酵素の役割2017

    • Author(s)
      清水 健、松本明郎、野田公俊
    • Organizer
      第90回 日本細菌学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-19
    • Data Source
      KAKENHI-PROJECT-16K08771
  • [Presentation] An evolutionary analysis of a novel virulence gene norV that encodes nitric oxide reductase in enterohemorrhagic Escherichia coli O1572016

    • Author(s)
      Takeshi Shimizu, Shinichiro Hirai, Eiji Yokoyama, Kimitoshi Ichimura and Masatoshi Noda
    • Organizer
      50th Joint Conference on Cholera and Other Bacterial Enteric Infections Panel
    • Place of Presentation
      Maryland (USA)
    • Year and Date
      2016-01-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670208
  • [Presentation] 一酸化窒素による腸管出血大腸菌の志賀毒素産生亢進機構の解析2016

    • Author(s)
      市村公敏、清水健、八尋錦之助、竹内裕紀、野田公俊
    • Organizer
      第89回日本細菌学会
    • Place of Presentation
      大阪府大阪市天王寺区
    • Year and Date
      2016-03-23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24390104
  • [Presentation] 腸管出血性大腸菌 O157が保持する新規病原因子一酸化窒素還元酵素遺伝子norVの進化的解析2016

    • Author(s)
      清水健、平井晋一郎、横山栄二、市村公敏、野田公俊
    • Organizer
      第89回日本細菌学会
    • Place of Presentation
      大阪府大阪市天王寺区
    • Year and Date
      2016-03-23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24390104
  • [Presentation] Shiga-toxigenic Escherichia coli SubAB-induced ER stress causes stress granule formation in mammalian cells2016

    • Author(s)
      Yahiro, K., H. Tsutsuki, K. Ogura, S. Iyoda, K. Ichimura, T. Shimizu, M. Ohnishi, K. Seto, J. Moss, and M. Noda.
    • Organizer
      Bethesda, USA
    • Place of Presentation
      Bethesda, USA
    • Year and Date
      2016-01-13
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24390104
  • [Presentation] An evolutionary analysis of a novel virulence gene norV that encodes nitric oxide reductase in enterohemorrhagic Escherichia coli O1572016

    • Author(s)
      Takeshi Shimizu,Shinichiro Hirai,Eiji Yokoyama, Kimitoshi Ichimura ando Masatoshi Noda
    • Organizer
      50th Joint Conference on Cholera and Other Bacterial Enteric Infections Panel
    • Place of Presentation
      Bethesda, USA
    • Year and Date
      2016-01-13
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24390104
  • [Presentation] 腸管出血性大腸菌 O157が保持する新規病原因子一酸化窒素還元酵素遺伝子norVの進化的解析2016

    • Author(s)
      清水 健、平井 晋一郎、横山 栄二、市村公敏、野田公俊
    • Organizer
      第89回 日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター(大阪府・大阪市)
    • Year and Date
      2016-03-23
    • Data Source
      KAKENHI-PROJECT-26670208
  • [Presentation] An evolutionary analysis of a novel virulence gene norV in enterohemorrhagic Escherichia coli O1572016

    • Author(s)
      Takeshi Shimizu, Shinichiro Hirai, Eiji Yokoyama, Kimitoshi Ichimura and Masatoshi Noda
    • Organizer
      The 9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-05-20
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08771
  • [Presentation] An evolutionary analysis of a novel virulence gene norV that encodes nitric oxide reductase in enterohemorrhagic Escherichia coli O1572015

    • Author(s)
      Takeshi Shimizu, Shinichiro Hirai, Eiji Yokoyama, Kimitoshi Ichimura and Masatoshi Noda
    • Organizer
      The 9th Triennial International Symposium on Shiga Toxin (Verocytotoxin) Producing Escherichia coli infections
    • Place of Presentation
      Boston (USA)
    • Year and Date
      2015-09-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670208
  • [Presentation] 腸管出血性大腸菌 O157が保持する一酸化窒素還元酵素遺伝子の進化的解析2015

    • Author(s)
      清水 健、平井 晋一郎、横山 栄二、市村公敏、野田公俊
    • Organizer
      第19回腸管出血性大腸菌感染症研究会
    • Place of Presentation
      国立医薬品食品衛生研究所(東京都・世田谷区)
    • Year and Date
      2015-07-09
    • Data Source
      KAKENHI-PROJECT-26670208
  • [Presentation] 一酸化窒素還元酵素:腸管出血性大腸菌の志賀毒素産生に影響を与える新規病原因子2014

    • Author(s)
      Takeshi Shimizu
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24390104
  • [Presentation] The surface sensor NlpE of enterohemorrhagic Escherichia coli contributes to2014

    • Author(s)
      Takeshi Shimizu, Kimitoshi Ichimura and Masatoshi Noda
    • Organizer
      48th US-Japan Cooperative Medical Sciences Program Conference on Cholera and Other Bacterial Enteric Infections
    • Place of Presentation
      Dhaka, Bangladesh
    • Data Source
      KAKENHI-PROJECT-24390104
  • [Presentation] Subtilase cytotoxin induces stress granule formation through PERK dependent pathway2013

    • Author(s)
      Hiroyasu Tsutsuki, Kinnosuke Yahiro, Tohru Shimizu, Masatoshi Noda
    • Organizer
      第86回日本細菌学会総会
    • Place of Presentation
      幕張メッセ(千葉)
    • Data Source
      KAKENHI-PROJECT-24390104
  • [Presentation] 一酸化窒素(NO)による腸管出血性大腸菌の感染制御と重症化機序2013

    • Author(s)
      松本明郎,清水健,津々木博康,中谷晴昭,野田公俊
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2013-03-21
    • Data Source
      KAKENHI-PLANNED-20117008
  • [Presentation] Role for the surface senssor NlpE of enterohemorrhagic Escherichia coli in adherence to cells.2013

    • Author(s)
      Takeshi Shimizu, Masatoshi Noda
    • Organizer
      第86回日本細菌学会総会
    • Place of Presentation
      幕張メッセ(千葉)
    • Data Source
      KAKENHI-PROJECT-24390104
  • [Presentation] Inhibitory effect of subtilase cytotoxin on LPS-induced nitric oxide production by macrophages.2012

    • Author(s)
      Hiroyasu Tsutsuki, Kinnosuke Yahiro, Takeshi Shimizu and Masatoshi Noda
    • Organizer
      THE 33rd NAITO CONFERENCE ON Oxygen Biology : Hypoxia, Oxidative Stress and Diseases.
    • Place of Presentation
      シャトレーゼガトーキングダム札幌(北海道)
    • Data Source
      KAKENHI-PROJECT-24390104
  • [Presentation] Molecular mechanism of inhibitory effect of SubAB on nitric oxide production by macrophages2012

    • Author(s)
      津々木博康、八尋錦之助、清水健、野田公俊
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎ブリックホール(長崎)(招待講演)
    • Year and Date
      2012-03-27
    • Data Source
      KAKENHI-PROJECT-21390127
  • [Presentation] Regulation of Subtilase cytotoxin (SubAB)-induced cell death by a PKR-like endoplasmic reticulum kinase (PERK)-dependent proteasome pathway in HeLa cells2012

    • Author(s)
      Kinnosuke Yahiro, Hiroyasu Tsutsuki, Kohei Ogura, Sayaka Nagasawa, Takeshi Shimizu, Joel Moss, Masatoshi Noda
    • Organizer
      7th US-Japan Cholera and Other Bacterial Enteric Infections Joint Panel Meeting.
    • Place of Presentation
      千葉大学薬学部創立120周年記念講堂(千葉)
    • Data Source
      KAKENHI-PROJECT-24390104
  • [Presentation] NO biosensor plasmid for investigating2012

    • Author(s)
      清水健, 津々木博康, 野田公俊
    • Organizer
      NO levels within macrophages during bacterial infection
    • Place of Presentation
      長崎
    • Year and Date
      2012-03-27
    • Data Source
      KAKENHI-PROJECT-21390127
  • [Presentation] Subtilase cytotoxin enhances E. coli survival in macrophages by suppression of nitric oxide production through the inhibition of NF-kB activation.2012

    • Author(s)
      Hiroyasu Tsutsuki, Kinnosuke Yahiro, Takeshi Shimizu, Masatoshi Noda
    • Organizer
      47th US Japan Cholera and Other Bacterial Enteric Infections Joint Panel Meeting.
    • Place of Presentation
      千葉大学薬学部創立120周年記念講堂(千葉)
    • Data Source
      KAKENHI-PROJECT-24390104
  • [Presentation] Molecular mechanism of inhibitory effect of2012

    • Author(s)
      津々木博康, 八尋錦之助, 清水健, 野田公俊
    • Organizer
      SubAB on nitric oxide production by macrophages
    • Place of Presentation
      長崎
    • Year and Date
      2012-03-27
    • Data Source
      KAKENHI-PROJECT-21390127
  • [Presentation] NO biosensor plasmid for investigating NO levels within macrophages during bacterial infection2012

    • Author(s)
      清水健、津々木博康、野田公俊
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎ブリックホール(長崎)
    • Year and Date
      2012-03-27
    • Data Source
      KAKENHI-PROJECT-21590478
  • [Presentation] NO biosensor plasmid for investigating NO levels within macrophages during bacterial infection2012

    • Author(s)
      清水健, 津々木博康, 野田公俊
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎、長崎ブリックホール
    • Data Source
      KAKENHI-PROJECT-21590478
  • [Presentation] NO biosensor plasmid for investigating NO levels within macrophages during bacterial infection2012

    • Author(s)
      清水健、津々木博康、野田公俊
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎ブリックホール(長崎)
    • Year and Date
      2012-03-27
    • Data Source
      KAKENHI-PROJECT-21390127
  • [Presentation] The nitric oxide reductase of enterohemorrahgic Escherichia coli plays an important role for the survival within macrophages2011

    • Author(s)
      Takeshi Shimizu, Hiroyasu Tsutsuki Masatoshi Noda
    • Organizer
      International Union of Microbiological Societies2011 Congress
    • Place of Presentation
      Sapporo Convention Center, Sapporo
    • Data Source
      KAKENHI-PROJECT-21590478
  • [Presentation] The nitric oxide reductase of enterohemorrhagic Escherichia coli 0157 : H7 increases Shiga toxin 2 production and plays an important role in its infection2011

    • Author(s)
      Takeshi Shimizu, Hiroyasu Tsutsuki, Akio Matsumoto, Haruaki Nakaya, Masatoshi Noda
    • Organizer
      46^<th> US-Japan Cholera and Other Bacterial Enteric Infections Joint Panel Meeting
    • Place of Presentation
      インド(招待講演)
    • Data Source
      KAKENHI-PROJECT-21590478
  • [Presentation] Subtilase cytotoxin inhibits the production of nitric oxide from macrophage2011

    • Author(s)
      津々木博康, 八尋錦之助, 清水健, 野田公俊
    • Place of Presentation
      北海道
    • Year and Date
      2011-09-10
    • Data Source
      KAKENHI-PROJECT-21390127
  • [Presentation] The nitric oxide reductase of Enterohemorrahgic Escherichia coli playsan important role for the survival within macrophages2011

    • Author(s)
      清水健、津々木博康、野田公俊
    • Organizer
      International Union of Microbiological Societies 2011 Congress
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2011-09-10
    • Data Source
      KAKENHI-PROJECT-21590478
  • [Presentation] The nitric oxide reductase of Enterohemorrahgicreductase of Enterohemorrahgic2011

    • Author(s)
      清水健, 津々木博康, 野田公俊
    • Organizer
      Escherichia coli plays an important role for the survival within macrophages
    • Place of Presentation
      北海道
    • Year and Date
      2011-09-10
    • Data Source
      KAKENHI-PROJECT-21390127
  • [Presentation] 腸管出血性大腸菌NO reductaseは志賀毒素2の産生を増加させる2011

    • Author(s)
      清水健、津々木博康、野田公俊
    • Organizer
      第58回トキシンシンポジウム
    • Place of Presentation
      順天堂大学(東京)(招待講演)
    • Year and Date
      2011-07-06
    • Data Source
      KAKENHI-PROJECT-21390127
  • [Presentation] 腸管出血性大腸菌 NO reductaseは志賀毒素2の産生を増加させる2011

    • Author(s)
      清水健, 津々木博康, 野田公俊
    • Organizer
      第58回トキシンシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-07-06
    • Data Source
      KAKENHI-PROJECT-21390127
  • [Presentation] The nitric oxide reductase of Enterohemorrahgic Escherichia coli plays an important role for the survival within macrophages2011

    • Author(s)
      清水健、津々木博康、野田公俊
    • Organizer
      International Union of Microbiological Societies 2011 Congress
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2011-09-10
    • Data Source
      KAKENHI-PROJECT-21390127
  • [Presentation] 腸管出血性大腸菌NO reductaseは志賀毒素2の産生を増加させる2011

    • Author(s)
      清水健、津々木博康、野田公俊
    • Organizer
      第58回トキシンシンポジウム
    • Place of Presentation
      順天堂大学(東京)(招待講演)
    • Year and Date
      2011-07-06
    • Data Source
      KAKENHI-PROJECT-21590478
  • [Presentation] 腸管出血性大腸菌の産生する新規SubABトキシンによるNO産生抑制機構の解明2011

    • Author(s)
      津々木博康, 八尋錦之助, 清水健, 野田公俊
    • Organizer
      第58回トキシンシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-07-06
    • Data Source
      KAKENHI-PROJECT-21390127
  • [Presentation] 腸管出血性大腸菌の産生する志賀毒素について2011

    • Author(s)
      清水健
    • Organizer
      緊急セミナー:腸管出血性大腸菌の今
    • Place of Presentation
      東京、東京慈恵会医科大学(招待講演)
    • Year and Date
      2011-08-02
    • Data Source
      KAKENHI-PROJECT-21590478
  • [Presentation] 野田公俊腸管出血性大腸菌のNO reductaseは志賀毒素2の産生を増加させる2011

    • Author(s)
      清水健, 津々木博康
    • Organizer
      第58回トキシンシンポジウムシンポジウム指名講演
    • Place of Presentation
      東京、順天堂大学
    • Data Source
      KAKENHI-PROJECT-21590478
  • [Presentation] 腸管出血性大腸菌の産生する新規SubABトキシンによるNO産生抑制機構の解明2011

    • Author(s)
      津々木博康、八尋錦之助、清水健、野田公俊
    • Organizer
      第58回トキシンシンポジウム
    • Place of Presentation
      順天堂大学(東京)(招待講演)
    • Year and Date
      2011-07-06
    • Data Source
      KAKENHI-PROJECT-21390127
  • [Presentation] Subtilase cytotoxin inhibits the production of nitric oxide from macrophage2011

    • Author(s)
      津々木博康、八尋錦之助、清水健、野田公俊
    • Organizer
      International Union of Microbiological Societies 2011 Congress
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2011-09-10
    • Data Source
      KAKENHI-PROJECT-21390127
  • [Presentation] Subtilase cytotoxin produced by Escherichia coli induces fatal hemorrhage in mice2011

    • Author(s)
      八尋錦之助、古川健、寺崎泰弘、辻厚至、清水健、盛永直子、野田公俊
    • Organizer
      46^<th> US-Japan Cholera and Other Bacterial Enteric Infections Joint Panel Meeting
    • Place of Presentation
      インド
    • Data Source
      KAKENHI-PROJECT-21390127
  • [Presentation] Haruaki Nakaya and Masatoshi Noda The nitric oxide reductase of enterohemorrhagic Escherichia coliO157:H7 increases Shiga toxin 2 production andplays an important role in its infection2011

    • Author(s)
      Takeshi Shimizu, Hiroyasu Tsutsuki, Akio Matsumoto
    • Organizer
      46^<th> Joint Conference on Cholera and Other Bacterial Enteric Infections Panel
    • Place of Presentation
      Kolkata, India
    • Data Source
      KAKENHI-PROJECT-21590478
  • [Presentation] 腸管出血性大腸菌が産生するSubtilase cytotoxinはマクロファージのNO産生を抑制する2011

    • Author(s)
      津々木博康, 八尋錦之助, 清水健, 野田公俊
    • Organizer
      第96回日本細菌学会関東支部総会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-06
    • Data Source
      KAKENHI-PROJECT-21390127
  • [Presentation] 清水健腸管出血性大腸菌の産生する志賀毒素について2011

    • Author(s)
      清水健
    • Organizer
      緊急セミナー:腸管出血性大腸菌の今
    • Place of Presentation
      東京、東京慈恵会医科大学
    • Data Source
      KAKENHI-PROJECT-21590478
  • [Presentation] 腸管出血性大腸菌の産生する新規SubABトキシンによるNO産生抑制機構の解明2010

    • Author(s)
      津々木博康, 八尋錦之助, 清水健, 野田公俊
    • Organizer
      インターラボセミナー
    • Place of Presentation
      千葉
    • Year and Date
      2010-12-11
    • Data Source
      KAKENHI-PROJECT-21390127
  • [Presentation] 腸管上皮細胞に接着した腸管出血性大腸菌はその志賀毒素1の産生量を増加させる2010

    • Author(s)
      清水健, 野田公俊
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-21590478
  • [Presentation] Adherent effects of enterohemorrahgic Escherichia coli to human intestinal epithelial cells on its Shiga toxins production2010

    • Author(s)
      Takeshi Shimizu Masatoshi Noda
    • Organizer
      45^<th> Joint Conference on Cholera and OtherBacterial Enteric Infections Panel
    • Place of Presentation
      Kyoto University, Kyoto
    • Data Source
      KAKENHI-PROJECT-21590478
  • [Presentation] Adherent effects of enterohemorrahgic Escberichia coli to human intestinal epithelial cells on its Shiga toxins production2010

    • Author(s)
      Takeshi Shimizu
    • Organizer
      45^<th> Joint Conference on Cholera and Other Bacterial Enteric Infections Panel
    • Place of Presentation
      Kyoto University, Kyoto
    • Year and Date
      2010-12-07
    • Data Source
      KAKENHI-PROJECT-21590478
  • [Presentation] Adherence of EHEC to Caco-2 cells induces the increase of Stx1 production2010

    • Author(s)
      清水健, 野田公俊
    • Organizer
      第83回日本細菌学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-21390127
  • [Presentation] 腸管出血性大腸菌の腸管上皮細胞への接着は病原因子の発現を増加させる2010

    • Author(s)
      清水健
    • Organizer
      第57回トキシンシンポジウム シンポジウム
    • Place of Presentation
      長浜、長浜ロイヤルホテル 指名講演
    • Year and Date
      2010-07-15
    • Data Source
      KAKENHI-PROJECT-21590478
  • [Presentation] 腸管出血性大腸菌の腸管上皮細胞への接着は病原因子の発現を増加させる2010

    • Author(s)
      清水健, 野田公俊
    • Organizer
      第57回トキシンシンポジウムシンポジウム指名講演
    • Place of Presentation
      長浜、長浜ロイヤルホテル
    • Data Source
      KAKENHI-PROJECT-21590478
  • [Presentation] Effect of phage-inducing agent on the number of Stx2-expressed cells in Shiga toxin-producing Escherichia coli2009

    • Author(s)
      清水健, 野田公俊
    • Organizer
      44th US-Japan Cholera and Other Bacterial Enteric Infections Joint Panel Meeting
    • Place of Presentation
      サンディエゴ、USA
    • Data Source
      KAKENHI-PROJECT-21390127
  • [Presentation] Effect of phage-inducing agent on the number of Stx2-expressed cells in Shiga toxin-producing Escherichia coli.2009

    • Author(s)
      Takeshi Shimizu
    • Organizer
      44^<rd> Joint Conference on Cholera and Other Bacterial Enteric Infections Panel
    • Place of Presentation
      San Diego, California
    • Data Source
      KAKENHI-PROJECT-21590478
  • [Presentation] 腸管出血性大腸菌には志賀毒素2に対する2種類の特異的な放出機構がある2009

    • Author(s)
      清水健、野田公俊
    • Organizer
      第82回日本細菌学会総会
    • Place of Presentation
      名古屋、名古屋国際会議場
    • Data Source
      KAKENHI-PROJECT-19590440
  • [Presentation] 腸管出血性大腸菌には志賀毒素2に対する2種類の特異的な放出機構がある2009

    • Author(s)
      清水健
    • Organizer
      第82回日本細菌学会総会
    • Place of Presentation
      名古屋, 名古屋国際会議場
    • Data Source
      KAKENHI-PROJECT-19590440
  • [Presentation] 腸管出血性大腸菌が産生する志賀毒素2の菌体外放出機構の解析2009

    • Author(s)
      清水健, 野田公俊
    • Organizer
      第56回トキシンシンポジウムシンポジウム指名講演
    • Place of Presentation
      岐阜、アルモニーテラッセ
    • Data Source
      KAKENHI-PROJECT-21590478
  • [Presentation] 腸管出血性大腸菌が産生する志賀毒素の菌体外放出機構2009

    • Author(s)
      清水健
    • Organizer
      第92回日本細菌学会関東支部総会シンポジウム
    • Place of Presentation
      東京、東京医科歯科大学
    • Data Source
      KAKENHI-PROJECT-21590478
  • [Presentation] Effect of phage-inducing agent on the number of Stx2-expressed cells in Shiga toxin-producing Escherichia coli2009

    • Author(s)
      Takeshi Shimizu, Yuko Ohta Masatoshi Noda
    • Organizer
      44^<rd> Joint Conference on Cholera and OtherBacterial Enteric Infections Panel
    • Place of Presentation
      San Diego, California
    • Data Source
      KAKENHI-PROJECT-21590478
  • [Presentation] A mechanism of Stx2 release from enterohemorrahgic Escherichia coli2009

    • Author(s)
      Takeshi Shimizu, Yuko Ohta Masatoshi Noda
    • Organizer
      The 13^<th> International Conference on EmergingInfectious Diseases in the Pacific Rim
    • Place of Presentation
      Kolkata, India
    • Data Source
      KAKENHI-PROJECT-21590478
  • [Presentation] A mechanism of Stx2 release from enterohemorrahgic Escherichia coli2009

    • Author(s)
      Takeshi Shimizu
    • Organizer
      The 13^<th> International Conference on Emerging Infectious Diseases in the Pacific Rim
    • Place of Presentation
      Kolkata, India
    • Data Source
      KAKENHI-PROJECT-21590478
  • [Presentation] 志賀様毒素2の分泌にはBサブユニットの特定のアミノ酸残基の側鎖が重要である2008

    • Author(s)
      清水 健
    • Organizer
      日本細菌学会
    • Place of Presentation
      国際会議場・京都
    • Year and Date
      2008-03-24
    • Data Source
      KAKENHI-PROJECT-19590440
  • [Presentation] 志賀毒素2の分泌にはBサブユニットの特定のアミノ酸残基の側鎖が重要である2008

    • Author(s)
      清水健、佐藤壽男、濱端崇、野田公俊
    • Organizer
      第81回日本細菌学会総会
    • Place of Presentation
      京都、国立京都国際会館
    • Data Source
      KAKENHI-PROJECT-19590440
  • [Presentation] A mechanism of Stx2 release from enterohemorrahgic Escherichia coli by a non-secretion system2008

    • Author(s)
      Takeshi Shimizu, Yuko Ohta and Masatoshi Noda
    • Organizer
      43^<rd> Joint Conference on Cholera and Other Bacterial Enteric Infections Panel
    • Place of Presentation
      Centennial Hall in Kyushu University, Fukuoka
    • Data Source
      KAKENHI-PROJECT-19590440
  • [Presentation] Binding mode of chimera Shiga toxins and their toxicity2007

    • Author(s)
      Takeshi Shimizu, Toshio Sato, Takashi Hamabata and Masatoshi Noda
    • Organizer
      42^<nd> Joint Conference on Cholera and Other Bacterial Enteric Infections Panel
    • Place of Presentation
      Austin, Texas
    • Data Source
      KAKENHI-PROJECT-19590440
  • [Presentation] Binding mode of chimera Shiga toxins and their toxicity2007

    • Author(s)
      Takeshi Shimizu
    • Organizer
      42ndJoint Conference on Cholera and Other Bacterial Enteric Infections Panel
    • Place of Presentation
      Austin,Texas
    • Data Source
      KAKENHI-PROJECT-19590440
  • [Presentation] 腸管出血性大腸菌の接着を認識する病原因子発現機構の解析

    • Author(s)
      清水 健、市村公敏、野田公俊
    • Organizer
      第18回腸管出血性大腸菌感染症研究会
    • Place of Presentation
      同志社大学室町キャンパス、京都府、京都市
    • Year and Date
      2014-07-15 – 2014-07-16
    • Data Source
      KAKENHI-PROJECT-26670208
  • [Presentation] The surface sensor NlpE of enterohemorrhagic Escherichia coli contributes to the regulation of virulence factors via adherence of bacteria to Caco-2 cells

    • Author(s)
      Takeshi Shimizu, Kimitoshi Ichimura and Masatoshi Noda
    • Organizer
      49th Joint Conference on Cholera and Other Bacterial Enteric Infections Panel
    • Place of Presentation
      Gainesville, Florida, USA
    • Year and Date
      2015-01-14 – 2015-01-16
    • Data Source
      KAKENHI-PROJECT-26670208
  • [Presentation] 腸管出血性大腸菌のsurface sensor NlpEは接着時にCpx経路によって病原因子の発現を調節する

    • Author(s)
      清水 健、市村公敏、野田公俊
    • Organizer
      第88回 日本細菌学会総会
    • Place of Presentation
      長良川国際会議場、岐阜県、岐阜市
    • Year and Date
      2015-03-26 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-26670208
  • 1.  NODA Masatoshi (60164703)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 59 results
  • 2.  MORINAGA Naoko (20092108)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 1 results
  • 3.  HAMABATA Takashi (40311427)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 3 results
  • 4.  KUWABARA Satoshi (70282481)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  MORI Masahiro (70345023)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  YAHIRO Kinnosuke (80345024)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 18 results
  • 7.  TSUTSUKI Hiroyasu (40586608)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 22 results
  • 8.  MATSUMOTO Akio (60437308)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 9.  OZAWA Kentaro (80507393)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 10.  MATSUMOTO Ayako (60444519)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 11.  NAKAYA Haruaki (60113594)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 12.  NABEYA Yoshihiro (40322028)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  小倉 康平 (00586612)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 14.  落合 武徳 (80114255)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  ENDO Hidemi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  SUTO Akira
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  SUZUKI Kotaro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  HASEBE Rie
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  伊豫田 淳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  吉栖 正典
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  中島 裕史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 22.  堀内 基広
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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