Shimizu Takeshi 清水健

… Alternative Names

SHIMIZU Takeshi 清水健

清水健シミズタケシ

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Researcher Number	70312840
Other IDs
Affiliation (Current)	2025: 千葉大学, 大学院医学研究院, 准教授
Affiliation (based on the past Project Information) *help	2025: 千葉大学, 大学院医学研究院, 准教授 2020 – 2022: 千葉大学, 大学院医学研究院, 准教授 2016 – 2018: 千葉大学, 大学院医学研究院, 准教授 2013 – 2016: 千葉大学, 医学(系)研究科(研究院), 准教授 2010 – 2012: 千葉大学, 大学院・医学研究院, 准教授 … More 2006 – 2009: 千葉大学, 大学院・医学研究院, 講師 2006: Chiba University, Graducate School of Medicine, Assistant Professor, 大学院医学研究院, 講師 2005: 筑波大学, 大学院・人間総合科学研究科, 講師 2003: 筑波大, 基礎医学系, 講師 2000 – 2001: 筑波大学, 基礎医学系, 講師 Less
Review Section/Research Field	Principal Investigator Bacteriology (including Mycology) / Basic Section 49050:Bacteriology-related / Bacteriology (including mycology) / Biological Sciences / Bacteriology (including Mycology) Except Principal Investigator Bacteriology (including Mycology) / Digestive surgery / Biological Sciences
Keywords	Principal Investigator 腸管出血性大腸菌 / 病原性 / 分泌 / NO還元酵素 / NO消去酵素 / 一酸化窒素 / Gb3 / 志賀毒素 / 志賀様毒素 / 細菌毒素 … More / 細菌 / 感染症 / RpoS / 一酸化窒素ストレス / small RNA / RNA結合タンパク質 / 一酸化窒素(NO) / EHEC / O157 / プラスミド / NO抵抗性 / 生体防御機構抵抗因子 / 重症化 / NOセンサー / 一酸化窒素還元酵素 / Bacterial infection / Virulence / Secretion / Shiga toxins / Enterohemorrhagic Escherichia coli / 細菌感染症 / 薬剤耐性 / 嫌気性 / 動物実験 / 宿主防御機構 / 嫌気条件 / 抗菌薬 / 増殖性 / 活性酸素種 / 嫌気状態 / 遺伝子発現 / NO reductase / NO / 毒素産生 / 最近 / ポストゲノム / MALDI-TOFMS / 2成分制御系 / 病原因子 / プロティアーゼ / 質量分析 / 2次元電気泳動 / ウェルシュ菌 / プロテオーム解析 … More Except Principal Investigator 志賀毒素 / 腸管出血性大腸菌 / 毒素 / 一酸化窒素 / SubAB / surgery / protein / adenosine 5' -diphosphate (ADP)-ribosylation / colorectal cancer / ADP-リポシル化 / 外科 / 蛋白質 / ADP-リボシル化 / 大腸癌 / NO / lipid-raft / 阻害剤 / 取り込み機構 / オートファジー / ｌipid-raft / 酸化ストレス / ストレスグラニュール / 細胞死 / 小胞体ストレス / Bcl-2 / ERストレス / BiP / サブチラーゼサイトトキシン / 受容体 / アポトーシス / ER ストレス / オルガネラ / 細胞膜 / ニトロソ化 / 活性酸素 / トランスポーター / 翻訳後修飾 / ニトロシル化 / 細胞間伝達 / Sーニトロソシステイン / S－ニトロシル化 / 神経変性疾患 / ニトロソストレス / ニトロソシステイン代謝酵素 / 細胞間情報伝達 / シグナル伝達 / S-ニトロソシステイン / S-ニトロシル化 / O157 / 0157 / STEC / AB成分毒素ファミリー / Stx / EHEC Less

RNA結合タンパク質依存的なRNA-RNA相互作用を介した新規ストレス応答増強機構の解明Principal Investigator
- Principal Investigator
  
  清水健
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Chiba University
Identification and functional analysis of resistance factors for enterohemorrhagic Escherichia coli-specific defense mechanismsPrincipal Investigator
- Principal Investigator
  
  Shimizu Takeshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Chiba University
A study on the acquisition mechanism of pathogenicity in intact NO reductase-type EHECPrincipal Investigator
- Principal Investigator
  
  Shimizu Takeshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Chiba University
Establishment of absolute anaerobic biology for pathogenic evaluation of EHECPrincipal Investigator
- Principal Investigator
  
  Shimizu Takeshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Chiba University
Elucidation of the pathogenic reinforcement action of enterohemorrhagic Escherichia coli produced SubAB
- Principal Investigator
  
  Noda Masatoshi
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Chiba University
Elucidation of Shiga-toxigenic Escherichia coli produced Subtilase cytotoxin-induced cell damage mechanism.
- Principal Investigator
  
  NODA Masatoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Chiba University
Study of Shiga toxin productions us ing in vivo analysisPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Takeshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Chiba University
Explication of the regulatory mechanism of S-nitrosylation signaling
- Principal Investigator
  
  MATSUMOTO Akio
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
  Osaka University
Studies on the SubAB toxin, its target organs, and its quick identification
- Principal Investigator
  
  NODA Masatoshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Chiba University
Analysis of secretion system of virulence factor in gram-negative bacteriaPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Takeshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Chiba University
Elucidation of a potential role of poly-ADP-ribosylation in the carcinogenesis or development of human colorectal carcinoma and its application for the diagnosis or trteatment of human colorectal carcinoma
- Principal Investigator
  
  NABEYA Yoshihiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Chiba University
Study on the virulence factors of enterohemorrhagic Escherichia coliPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Takeshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Chiba University
  University of Tsukuba
病原細菌における病原因子の機能的検索法の開発Principal Investigator
- Principal Investigator
  
  清水健
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
ポストゲノムプロジェクトにおけるプロテオーム解析Principal Investigator
- Principal Investigator
  
  清水健
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  University of Tsukuba

[Journal Article] Clarification of relationship between single-nucleotide polymorphism panels of Shiga toxin-producing <i>Escherichia coli</i> O157:H7/H- strains2022
- Author(s)
  HIRAI Shinichiro、YOKOYAMA Eiji、SHIWA Yuh、ISHIGE Taichiro、ANDO Naoshi、SHIMIZU Takeshi、MURAKAMI Satoshi
- Journal Title
  
  Journal of Veterinary Medical Science
  
  Volume: 84 Issue: 10 Pages: 1399-1405
- DOI
  10.1292/jvms.22-0242
- ISSN
  0916-7250, 1347-7439
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07474
[Journal Article] Enhanced production of Shiga toxin 1 in enterohaemorrhagic Escherichia coli by oxygen2021
- Author(s)
  Shimizu Takeshi、Onuki Manami、Suzuki Shin、Hirai Shinichiro、Yokoyama Eiji、Matsumoto Akio、Hamabata Takashi
- Journal Title
  
  Microbiology
  
  Volume: 167 Issue: 12 Pages: 1-11
- DOI
  10.1099/mic.0.001122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07474
[Journal Article] Effect of sub-MICs of macrolides on the sensitivity of Pseudomonas aeruginosa to nitrosative stress: effectiveness against P. aeruginosa with and without multidrug resistance.2020
- Author(s)
  Takeshi Shimizu, Tohru Miyoshi-Akiyama, Kohei Ogura, Shota Murata, Shota Ishige, Kiyohiro Kai, Konosuke Mitsutsuka, Haruyoshi Tomita, Koichi Tanimoto, and Akio Matsumoto
- Journal Title
  
  Antimicrob. Agents Chemother.
  
  Volume: 64 Issue: 10
- DOI
  10.1128/aac.01180-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07474, KAKENHI-PROJECT-18K07133
[Journal Article] Mechanism of inhibition of Shiga-toxigenic Escherichia coli SubAB cytotoxicity by steroids and diacylglycerol analogues2018
- Author(s)
  Yahiro Kinnosuke、Nagasawa Sayaka、Ichimura Kimitoshi、Takeuchi Hiroki、Ogura Kohei、Tsutsuki Hiroyasu、Shimizu Takeshi、Iyoda Sunao、Ohnishi Makoto、Iwase Hirotaro、Moss Joel、Noda Masatoshi
- Journal Title
  
  Cell Death Discovery
  
  Volume: 4 Issue: 1 Pages: 22-22
- DOI
  10.1038/s41420-017-0007-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08486, KAKENHI-PROJECT-16K08770, KAKENHI-PROJECT-17K10019, KAKENHI-PROJECT-18K07133, KAKENHI-PROJECT-16K08771
[Journal Article] Nitric oxide-enhanced Shiga toxin production was regulated by Fur and RecA in enterohemorrhagic Escherichia coli O157.2017
- Author(s)
  K. Ichimura, Shimizu. T, Takeuchi. H, Matsumoto. A, Yahiro. K, Noda. M,
- Journal Title
  
  MicrobiologyOpen
  
  Volume: 印刷中 Issue: 4 Pages: 1-17
- DOI
  10.1002/mbo3.461
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390104, KAKENHI-PROJECT-26670208, KAKENHI-PROJECT-16K08771, KAKENHI-PROJECT-16K15315, KAKENHI-PROJECT-16K08770
[Journal Article] The surface sensor NlpE of enterohemorrhagic Escherichia coli contributes to regulation of the type III secretion system and flagella by the Cpx response to adhesion2016
- Author(s)
  Takeshi Shimizu, Kimitoshi Ichimura and Masatoshi Noda
- Journal Title
  
  Infect. Immun.
  
  Volume: 84 Issue: 2 Pages: 537-549
- DOI
  10.1128/iai.00881-15
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670208, KAKENHI-PROJECT-24390104
[Journal Article] An evolutionary analysis of nitric oxide reductase gene norV in enterohemorrhagic Escherichia coli O1572015
- Author(s)
  Takeshi Shimizu, Shinichiro Hirai, Eiji Yokoyama, Kimitoshi Ichimura and Masatoshi Noda
- Journal Title
  
  Infection, Genetics and Evolution
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26670208
[Journal Article] An evolutionary analysis of nitric oxide reductase gene norV in enterohemorrhagic Escherichia coli O1572015
- Author(s)
  Takeshi Shimizu, Shinichiro Hirai, Eiji Yokoyama, Kimitoshi Ichimura and Masatoshi Noda
- Journal Title
  
  Infect. Genet. Evol.
  
  Volume: 33 Pages: 176-181
- DOI
  10.1016/j.meegid.2015.04.027
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670208
[Journal Article] 腸管出血性大腸菌による食中毒重症化メカニズム2013
- Author(s)
  清水　健、野田　公俊
- Journal Title
  
  日本医事新報
  
  Volume: 4614 Pages: 98-99
- Data Source
  KAKENHI-PROJECT-24390104
[Journal Article] Large - scale preparation of Shiga toxin 2 1n Escherichia coli for toxoid vaccine antigen production.2013
- Author(s)
  Hideyuki Arimitsu, Keiko Sasaki, Takeshi Shimizu, Kentaro Tsukamoto, Toshiyasu Shimizu and Takao Tsuji
- Journal Title
  
  Microbiol. Immunol.
  
  Volume: 57 Issue: 1 Pages: 38-45
- DOI
  10.1111/j.1348-0421.2012.12004.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390104
[Journal Article] Large-scale preparation of Shiga toxin 2 in Escherichia coli for toxoid vaccine antigen production2013
- Author(s)
  Hideyuki Arimitsu, Keiko Sasaki, Takeshi Shimizu, Kentaro Tsukamoto,
- Journal Title
  
  Microbiol. Immunol.
  
  Volume: 57 Pages: 38-45
- NAID
  40019554365
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390104
[Journal Article] 腸管出血性大腸菌の重症化要因2013
- Author(s)
  清水　健、野田　公俊
- Journal Title
  
  感染・炎症・免疫
  
  Volume: 43 Pages: 74-76
- Data Source
  KAKENHI-PROJECT-24390104
[Journal Article] Proteomic analysis of S-nitrosylation induced by 1-methyl-4-phenylpyridinium (MPP+)2012
- Author(s)
  Komatsubara A. T.,Asano T.,Tsumoto H., Shimizu K.,Nishiuchi T.,Yoshizumi M., Ozawa K
- Journal Title
  
  Proteome Sci
  
  Volume: 10 Issue: 1 Pages: 74-80
- DOI
  10.1186/1477-5956-10-74
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20117008, KAKENHI-PROJECT-23590306
[Journal Article] Proteomic analysis of the role of S-nitrosoglutathione reductase in lipopolysaccharide-challenged mice2012
- Author(s)
  0zawa K.,Tsumoto H.,Wei W.,Tang C. H., Konlatsubara A. T.,Kawafune H.,Shimizu K., Liu L., Tsujimoto G
- Journal Title
  
  Proteomics
  
  Volume: 12 Issue: 12 Pages: 2024-2035
- DOI
  10.1002/pmic.201100666
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20117008
[Journal Article] 腸管出血性大腸菌による食中毒重症化メカニズム2012
- Author(s)
  清水健、野田公俊
- Journal Title
  
  日本医事新報
  
  Volume: 4614 Pages: 98-99
- Data Source
  KAKENHI-PROJECT-24390104
[Journal Article] Recombinant Shiga toxin B subunit can induce neutralizing immunoglobulin Y antibody.2012
- Author(s)
  Paola Neri, Shunji Tokoro, Tsuyoshi Sugiyama, Kouji Umeda, Takeshi Shimizu, Takao Tsuji, Yoshikatsu Kodama and Hiroshi Mori
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 35 Pages: 917-923
- NAID
  130001872174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390104
[Journal Article] Recombinant Shiga toxin B subunit can induce neutralizing IgY antibody2012
- Author(s)
  Paola Neri, Shunji Tokoro, Tsuyoshi Sugiyama, Kouji Umeda, Takeshi Shimizu, Takao Tsuji, Yoshikatsu Kodama, Hiroshi Mori
- Journal Title
  
  Biol.Pharm.Bull.
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590478
[Journal Article] Subtilase cytotoxin enhances Escherichia coli survival in macrophages by suppression of nitric oxide production through the inhibition of NF-κB activation2012
- Author(s)
  Tsutsuki H, Yahiro K, Suzuki K, Suto A, Ogura K, Nagasawa S, Ihara H, Shimizu T, Nakajima H, Moss J, Noda M
- Journal Title
  
  Infect Immun
  
  Volume: 80 Issue: 11 Pages: 3939-51
- DOI
  10.1128/iai.00581-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591432, KAKENHI-PROJECT-23591458, KAKENHI-PROJECT-24390104
[Journal Article] Characterization of intracellular localization of PrP^<Sc> in prioninfected cells using monoclonal antibody that recognizes the region consisting of amino acids 119-127 of mouse PrP2012
- Author(s)
  Yamasaki T., Suzuki A., Shimizu T., Watarai M., Hasebe R., Horiuchi M.
- Journal Title
  
  Journal of General Virology
  
  Volume: vol.93 no.3 Issue: 3 Pages: 668-680
- DOI
  10.1099/vir.0.037101-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J04181, KAKENHI-PROJECT-21590478, KAKENHI-PROJECT-23248050, KAKENHI-PROJECT-23658233, KAKENHI-PROJECT-23780303
[Journal Article] The nitric oxide reductase of enterohemorrhagic Escherichia coli plays an important role for the survival within macrophages2012
- Author(s)
  Shimizu T, Tsutsuki H, Matsumoto A, Nakaya H, Noda M
- Journal Title
  
  Mol Microbiol
  
  Volume: 85 Issue: 3 Pages: 492-512
- DOI
  10.1111/j.1365-2958.2012.08122.x
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20117008, KAKENHI-PROJECT-23390053, KAKENHI-PROJECT-24390104, KAKENHI-PROJECT-24659111
[Journal Article] Construction of a novel bioluminescent reporter system for investigating Shiga toxin expression of enterohaemorrhagic.Escbericbia coli2011
- Author(s)
  Takeshi Shimizu
- Journal Title
  
  Gene
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590478
[Journal Article] Specific egg yolk immunoglobulin as a new preventive approach for Shiga-toxin-mediated diseases2011
- Author(s)
  Paola Neri, Shunji Tokoro, Ryo Kobayashi, Tsuyoshi Sugiyama, Kouji Umeda, Takeshi Shimizu, Takao Tsuji, Yoshikatsu Kodama, Keiji Oguma Hiroshi Mori
- Journal Title
  
  PLoS ONE
  
  Volume: 6(10) Issue: 10 Pages: e26526-e26526
- DOI
  10.1371/journal.pone.0026526
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590478, KAKENHI-PROJECT-21590497
[Journal Article] Construction of a novel bioluminescent reportersystem for investigating Shiga toxin expression of enterohaemorrhagic2011
- Author(s)
  Takeshi Shimizu, Yuko Ohta, Hiroyasu Tsutsuki Masatoshi Noda
- Journal Title
  
  Escherichia coli. Gene
  
  Volume: 478 Issue: 1-2 Pages: 1-10
- DOI
  10.1016/j.gene.2011.01.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590478
[Journal Article] Shiga toxin 2 is specifically released from bacterial cells by two different mechanisms2009
- Author(s)
  Takeshi Shimizu, Yuko Ohta and Masatoshi Noda
- Journal Title
  
  Infect.Immun. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590440
[Journal Article] Differential entry of Botulinum neurotoxin A into neural and intestinal cells2009
- Author(s)
  Aurelie Couesnon, Takeshi Shimizu and Michel R. Popoff
- Journal Title
  
  Cell. Microbiol. 11
  
  Pages: 289-308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590440
[Journal Article] Shiga toxin 2 is specifically released from bacterial cells by two different mechanisms.2009
- Author(s)
  Takeshi Shimizu
- Journal Title
  
  Infect.Immun. 77
  
  Pages: 2813-2823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590478
[Journal Article] Shiga toxin 2 is specifically released from bacterial cells by two different mechanisms2009
- Author(s)
  Takeshi Shimizu, Yuko Ohta Masatoshi Noda,
- Journal Title
  
  Infect. Immun
  
  Volume: 77 Issue: 7 Pages: 2813-2823
- DOI
  10.1128/iai.00060-09
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590478
[Journal Article] Differential entry of Botulinum neurotoxin A into neural andintestinal cells2009
- Author(s)
  Aurelie Couesnon, Takeshi Shimizu Michel R. Popoff
- Journal Title
  
  Cell. Microbiol
  
  Volume: 11 Issue: 2 Pages: 289-308
- DOI
  10.1111/j.1462-5822.2008.01253.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590478
[Journal Article] A nasal vaccine comprising B-subunit derivative of Shiga toxin 2 for cross-protection aganst Shiga toxin types 1 and 22008
- Author(s)
  Takao Tsuji, Takeshi Shimizu, Keiko Sasaki, Kentaro Tsukamoto, Hideyuki Arimitsu, Sadayuki Ochi, Toshiyasu Shimizu, Koki Taniguchi, Masatoshi Noda, Paola Neri, Hiroshi Mori
- Journal Title
  
  Vaccine 26
  
  Pages: 2092-2099
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590440
[Journal Article] Protection of mice from Shiga toxin-2 toxemia by mucosal vaccine of Shiga toxin 2B-His with Escherichia coli enterotoxin2008
- Author(s)
  Takao Tsuji, Takeshi Shimizu, Keiko Sasaki, Toshiyasu Shimizu, Kentaro Tsukamoto, Hideyuki Arimitsu, Sadayuki Ochi, Satoshi Sugiyama, Koki Taniguchi, Paola Neri, Hiroshi Mori
- Journal Title
  
  Vaccine 26
  
  Pages: 469-476
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590440
[Journal Article] Serine 31 residue of B subunit of Shiga toxin 2 is essential for the secretion in Enterohemorrhagic Escherichia coli2007
- Author(s)
  Takeshi Shimizu
- Journal Title
  
  Infect. Immun 75
  
  Pages: 2189-2200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590440
[Journal Article] Serine 31 residue of B subunit of Shiga toxin 2 is essentia for the secretion in Enterohemorrhagic Escherichia coli.2007
- Author(s)
  Takeshi Shimizu
- Journal Title
  
  Infection and Immunity (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590382
[Journal Article] Serine 31 residue of B subunit of Shiga toxin 2 is essential for thsecretion in Enterohemorrhagic Escherichia coli.2007
- Author(s)
  Takeshi Shimizu
- Journal Title
  
  Infection and Immunity in press
- Data Source
  KAKENHI-PROJECT-17590382
[Journal Article] Receptor affinity, stability and binding mode of Shiga toxins are determinants of toxicity2007
- Author(s)
  Takeshi Shimizu, Toshio Sato, Satomi Kawakami, Toshiko Ohta, Masatoshi Noda and Takashi Hamabata
- Journal Title
  
  Microb. Pathog. 43
  
  Pages: 88-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590440
[Journal Article] Serine 31 residue of B subunit of Shiga toxin 2 is essential for the secretion in Enterohemorrhagic Escherichia coli2007
- Author(s)
  Takeshi Shimizu, Satomi Kawakami, Toshio Sato, Terumi Sasaki, Masato Higashide, Takashi Hamabata, Toshiko Ohta and Masatoshi Noda
- Journal Title
  
  Infect. Immun. 75
  
  Pages: 2189-2200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590440
[Journal Article] Receptor affinity, stability and binding mode of Shliga toxins are determinants of toxicity2007
- Author(s)
  Takeshi Shimizu
- Journal Title
  
  Microb. Pathog 43
  
  Pages: 88-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590440
[Journal Article] Serine 31 residue of B subunit of Shiga toxin 2 is essential for the secretion in Enterohemorrhagic Escherichia coli
- Author(s)
  Takeshi Shimizu
- Journal Title
  
  Infection and Immunity (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590382
[Journal Article] Yoshikatsu Kodama and Hiroshi Mori, 2012. Recombinant Shiga toxin B subunit can induce neutralizing IgY antibody
- Author(s)
  Paola Neri, Shunji Tokoro, Tsuyoshi Sugiyama, Kouji Umeda, Takeshi Shimizu, Takao Tsuji
- Journal Title
  
  Pharm. Bull
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590478
[Patent] 組換えベクター、該ベクターで形質転換された微生物を利用した一酸化窒素消去を抑制する化合物のスクリーニング方法及び細胞内一酸化窒素濃度の測定方法2016
- Inventor(s)
  松本明郎、清水　健、野田　公俊
- Industrial Property Rights Holder
  松本明郎、清水　健、野田　公俊
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-114134
- Filing Date
  2016-06-08
- Data Source
  KAKENHI-PROJECT-16K08771
[Patent] -酸化窒素を探知するための形質転換用組換えベクター、およびこれを用いた一酸化窒素センサ細胞2011
- Inventor(s)
  清水健, 津々木博康, 野田公俊
- Industrial Property Rights Holder
  国立大学法人, 千葉大学
- Industrial Property Number
  2011-101623
- Filing Date
  2011-04-28
- Data Source
  KAKENHI-PROJECT-21390127
[Patent] 一酸化窒素を探知するための形質転換用組換えベクター、およびこれを用いた一酸化窒素センサ細胞2011
- Inventor(s)
  清水健, 津々木博康, 野田公俊
- Industrial Property Rights Holder
  国立大学法人千葉大学
- Industrial Property Number
  2011-101623
- Filing Date
  2011-04-28
- Data Source
  KAKENHI-PROJECT-21590478
[Presentation] Enhanced resistance of enterohemorrhagic Escherichia coli to bactericidal substances by plasmid factor2023
- Author(s)
  Takeshi Shimizu, Shin Suzuki and Takashi Hamabata
- Organizer
  第９６回　日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-20K07474
[Presentation] Enhanced production of Shiga toxin 2 in enterohemorrhagic Escherichia coli by oxygen2022
- Author(s)
  Takeshi Shimizu, Manami Onuki, Shinichiro Hirai, Eiji Yokoyama, Akio Matsumoto and Takashi Hamabata
- Organizer
  第９５回　日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-20K07474
[Presentation] 腸管出血性大腸菌のプラスミド因子による生体殺菌物質に対する抵抗性の増強2022
- Author(s)
  清水　健、鈴木　眞、濱端　崇
- Organizer
  第２４回腸管出血性大腸菌感染症研究会
- Data Source
  KAKENHI-PROJECT-20K07474
[Presentation] 腸管出血性大腸菌の志賀毒素産生における酸素の影響2021
- Author(s)
  清水　健、大貫真奈美、松本明郎、濱端　崇
- Organizer
  第９４回　日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-20K07474
[Presentation] 志賀毒素産生とNO還元酵素2018
- Author(s)
  清水健
- Organizer
  第１０１回　日本細菌学会関東支部総会　シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-16K08771
[Presentation] Cooperative roles of NO-metabolizing enzymes in enterohemorrhagic Escherichia coli against nitrosative stress2018
- Author(s)
  Takeshi Shimizu, Akio Matsumoto and Masatoshi Noda
- Organizer
  52th Joint Conference on Cholera and Other Bacterial Enteric Infections Panel
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08771
[Presentation] 腸管出血性大腸菌の菌体内NO濃度を減少させるNO代謝酵素群の協調的な役割2018
- Author(s)
  清水健、松本明郎、野田公俊
- Organizer
  第９１回　日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-16K08771
[Presentation] An evolutionary analysis of a novel virulence gene norV in enterohemorrhagic Escherichia coli O1572018
- Author(s)
  Takeshi Shimizu, Shinichiro Hirai, Eiji Yokoyama, Kimitoshi Ichimura and Masatoshi Noda
- Organizer
  The 7th Global Network Forum on Infection and Immunity
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08771
[Presentation] in vivo解析による腸管内での志賀毒素産生様式の解明2017
- Author(s)
  清水健、松本明郎、野田公俊
- Organizer
  第２１回腸管出血性大腸菌感染症研究会
- Data Source
  KAKENHI-PROJECT-16K08771
[Presentation] Role of NO-metabolizing enzymes in enterohemorrahgic Escherichia coli under NO stress conditions2017
- Author(s)
  Takeshi Shimizu, Akio　Matsumoto and Masatoshi Noda
- Organizer
  日本細菌学会総会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-19
- Data Source
  KAKENHI-PROJECT-26670208
[Presentation] NOストレス環境における腸管出血性大腸菌のNO代謝酵素の役割2017
- Author(s)
  清水　健、松本明郎、野田公俊
- Organizer
  第９０回　日本細菌学会総会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-19
- Data Source
  KAKENHI-PROJECT-16K08771
[Presentation] An evolutionary analysis of a novel virulence gene norV that encodes nitric oxide reductase in enterohemorrhagic Escherichia coli O1572016
- Author(s)
  Takeshi Shimizu, Shinichiro Hirai, Eiji Yokoyama, Kimitoshi Ichimura and Masatoshi Noda
- Organizer
  50th Joint Conference on Cholera and Other Bacterial Enteric Infections Panel
- Place of Presentation
  Maryland (USA)
- Year and Date
  2016-01-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670208
[Presentation] 一酸化窒素による腸管出血大腸菌の志賀毒素産生亢進機構の解析2016
- Author(s)
  市村公敏、清水健、八尋錦之助、竹内裕紀、野田公俊
- Organizer
  第89回日本細菌学会
- Place of Presentation
  大阪府大阪市天王寺区
- Year and Date
  2016-03-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] 腸管出血性大腸菌 O157が保持する新規病原因子一酸化窒素還元酵素遺伝子norVの進化的解析2016
- Author(s)
  清水健、平井晋一郎、横山栄二、市村公敏、野田公俊
- Organizer
  第89回日本細菌学会
- Place of Presentation
  大阪府大阪市天王寺区
- Year and Date
  2016-03-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] Shiga-toxigenic Escherichia coli SubAB-induced ER stress causes stress granule formation in mammalian cells2016
- Author(s)
  Yahiro, K., H. Tsutsuki, K. Ogura, S. Iyoda, K. Ichimura, T. Shimizu, M. Ohnishi, K. Seto, J. Moss, and M. Noda.
- Organizer
  Bethesda, USA
- Place of Presentation
  Bethesda, USA
- Year and Date
  2016-01-13
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] An evolutionary analysis of a novel virulence gene norV that encodes nitric oxide reductase in enterohemorrhagic Escherichia coli O1572016
- Author(s)
  Takeshi Shimizu,Shinichiro Hirai,Eiji Yokoyama, Kimitoshi Ichimura ando Masatoshi Noda
- Organizer
  50th Joint Conference on Cholera and Other Bacterial Enteric Infections Panel
- Place of Presentation
  Bethesda, USA
- Year and Date
  2016-01-13
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] 腸管出血性大腸菌 O157が保持する新規病原因子一酸化窒素還元酵素遺伝子norVの進化的解析2016
- Author(s)
  清水　健、平井　晋一郎、横山　栄二、市村公敏、野田公俊
- Organizer
  第８９回　日本細菌学会総会
- Place of Presentation
  大阪国際交流センター（大阪府・大阪市）
- Year and Date
  2016-03-23
- Data Source
  KAKENHI-PROJECT-26670208
[Presentation] An evolutionary analysis of a novel virulence gene norV in enterohemorrhagic Escherichia coli O1572016
- Author(s)
  Takeshi Shimizu, Shinichiro Hirai, Eiji Yokoyama, Kimitoshi Ichimura and Masatoshi Noda
- Organizer
  The 9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-05-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08771
[Presentation] An evolutionary analysis of a novel virulence gene norV that encodes nitric oxide reductase in enterohemorrhagic Escherichia coli O1572015
- Author(s)
  Takeshi Shimizu, Shinichiro Hirai, Eiji Yokoyama, Kimitoshi Ichimura and Masatoshi Noda
- Organizer
  The 9th Triennial International Symposium on Shiga Toxin (Verocytotoxin) Producing Escherichia coli infections
- Place of Presentation
  Boston (USA)
- Year and Date
  2015-09-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670208
[Presentation] 腸管出血性大腸菌 O157が保持する一酸化窒素還元酵素遺伝子の進化的解析2015
- Author(s)
  清水　健、平井　晋一郎、横山　栄二、市村公敏、野田公俊
- Organizer
  第１９回腸管出血性大腸菌感染症研究会
- Place of Presentation
  国立医薬品食品衛生研究所（東京都・世田谷区）
- Year and Date
  2015-07-09
- Data Source
  KAKENHI-PROJECT-26670208
[Presentation] 一酸化窒素還元酵素：腸管出血性大腸菌の志賀毒素産生に影響を与える新規病原因子2014
- Author(s)
  Takeshi Shimizu
- Organizer
  第87回日本細菌学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] The surface sensor NlpE of enterohemorrhagic Escherichia coli contributes to2014
- Author(s)
  Takeshi Shimizu, Kimitoshi Ichimura and Masatoshi Noda
- Organizer
  48th　US-Japan Cooperative Medical Sciences Program Conference on Cholera and Other Bacterial Enteric Infections
- Place of Presentation
  Dhaka, Bangladesh
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] Subtilase cytotoxin induces stress granule formation through PERK dependent pathway2013
- Author(s)
  Hiroyasu Tsutsuki, Kinnosuke Yahiro, Tohru Shimizu, Masatoshi Noda
- Organizer
  第86回日本細菌学会総会
- Place of Presentation
  幕張メッセ(千葉)
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] 一酸化窒素（ＮＯ）による腸管出血性大腸菌の感染制御と重症化機序2013
- Author(s)
  松本明郎，清水健，津々木博康，中谷晴昭，野田公俊
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Year and Date
  2013-03-21
- Data Source
  KAKENHI-PLANNED-20117008
[Presentation] Role for the surface senssor NlpE of enterohemorrhagic Escherichia coli in adherence to cells.2013
- Author(s)
  Takeshi Shimizu, Masatoshi Noda
- Organizer
  第86回日本細菌学会総会
- Place of Presentation
  幕張メッセ(千葉)
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] Inhibitory effect of subtilase cytotoxin on LPS-induced nitric oxide production by macrophages.2012
- Author(s)
  Hiroyasu Tsutsuki, Kinnosuke Yahiro, Takeshi Shimizu and Masatoshi Noda
- Organizer
  THE 33rd NAITO CONFERENCE ON Oxygen Biology : Hypoxia, Oxidative Stress and Diseases.
- Place of Presentation
  シャトレーゼガトーキングダム札幌(北海道)
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] Molecular mechanism of inhibitory effect of SubAB on nitric oxide production by macrophages2012
- Author(s)
  津々木博康、八尋錦之助、清水健、野田公俊
- Organizer
  第85回日本細菌学会総会
- Place of Presentation
  長崎ブリックホール(長崎)(招待講演)
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] Regulation of Subtilase cytotoxin (SubAB)-induced cell death by a PKR-like endoplasmic reticulum kinase (PERK)-dependent proteasome pathway in HeLa cells2012
- Author(s)
  Kinnosuke Yahiro, Hiroyasu Tsutsuki, Kohei Ogura, Sayaka Nagasawa, Takeshi Shimizu, Joel Moss, Masatoshi Noda
- Organizer
  7th US-Japan Cholera and Other Bacterial Enteric Infections Joint Panel Meeting.
- Place of Presentation
  千葉大学薬学部創立120周年記念講堂(千葉)
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] NO biosensor plasmid for investigating2012
- Author(s)
  清水健, 津々木博康, 野田公俊
- Organizer
  NO levels within macrophages during bacterial infection
- Place of Presentation
  長崎
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] Subtilase cytotoxin enhances E. coli survival in macrophages by suppression of nitric oxide production through the inhibition of NF-kB activation.2012
- Author(s)
  Hiroyasu Tsutsuki, Kinnosuke Yahiro, Takeshi Shimizu, Masatoshi Noda
- Organizer
  47th US Japan Cholera and Other Bacterial Enteric Infections Joint Panel Meeting.
- Place of Presentation
  千葉大学薬学部創立120周年記念講堂(千葉)
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] Molecular mechanism of inhibitory effect of2012
- Author(s)
  津々木博康, 八尋錦之助, 清水健, 野田公俊
- Organizer
  SubAB on nitric oxide production by macrophages
- Place of Presentation
  長崎
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] NO biosensor plasmid for investigating NO levels within macrophages during bacterial infection2012
- Author(s)
  清水健、津々木博康、野田公俊
- Organizer
  第85回日本細菌学会総会
- Place of Presentation
  長崎ブリックホール(長崎)
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-21590478
[Presentation] NO biosensor plasmid for investigating NO levels within macrophages during bacterial infection2012
- Author(s)
  清水健, 津々木博康, 野田公俊
- Organizer
  第85回日本細菌学会総会
- Place of Presentation
  長崎、長崎ブリックホール
- Data Source
  KAKENHI-PROJECT-21590478
[Presentation] NO biosensor plasmid for investigating NO levels within macrophages during bacterial infection2012
- Author(s)
  清水健、津々木博康、野田公俊
- Organizer
  第85回日本細菌学会総会
- Place of Presentation
  長崎ブリックホール(長崎)
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] The nitric oxide reductase of enterohemorrahgic Escherichia coli plays an important role for the survival within macrophages2011
- Author(s)
  Takeshi Shimizu, Hiroyasu Tsutsuki Masatoshi Noda
- Organizer
  International Union of Microbiological Societies2011 Congress
- Place of Presentation
  Sapporo Convention Center, Sapporo
- Data Source
  KAKENHI-PROJECT-21590478
[Presentation] The nitric oxide reductase of enterohemorrhagic Escherichia coli 0157 : H7 increases Shiga toxin 2 production and plays an important role in its infection2011
- Author(s)
  Takeshi Shimizu, Hiroyasu Tsutsuki, Akio Matsumoto, Haruaki Nakaya, Masatoshi Noda
- Organizer
  46^<th> US-Japan Cholera and Other Bacterial Enteric Infections Joint Panel Meeting
- Place of Presentation
  インド(招待講演)
- Data Source
  KAKENHI-PROJECT-21590478
[Presentation] Subtilase cytotoxin inhibits the production of nitric oxide from macrophage2011
- Author(s)
  津々木博康, 八尋錦之助, 清水健, 野田公俊
- Place of Presentation
  北海道
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] The nitric oxide reductase of Enterohemorrahgic Escherichia coli playsan important role for the survival within macrophages2011
- Author(s)
  清水健、津々木博康、野田公俊
- Organizer
  International Union of Microbiological Societies 2011 Congress
- Place of Presentation
  札幌コンベンションセンター(北海道)
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-21590478
[Presentation] The nitric oxide reductase of Enterohemorrahgicreductase of Enterohemorrahgic2011
- Author(s)
  清水健, 津々木博康, 野田公俊
- Organizer
  Escherichia coli plays an important role for the survival within macrophages
- Place of Presentation
  北海道
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] 腸管出血性大腸菌NO reductaseは志賀毒素2の産生を増加させる2011
- Author(s)
  清水健、津々木博康、野田公俊
- Organizer
  第58回トキシンシンポジウム
- Place of Presentation
  順天堂大学(東京)(招待講演)
- Year and Date
  2011-07-06
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] 腸管出血性大腸菌 NO reductaseは志賀毒素2の産生を増加させる2011
- Author(s)
  清水健, 津々木博康, 野田公俊
- Organizer
  第58回トキシンシンポジウム
- Place of Presentation
  東京
- Year and Date
  2011-07-06
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] The nitric oxide reductase of Enterohemorrahgic Escherichia coli plays an important role for the survival within macrophages2011
- Author(s)
  清水健、津々木博康、野田公俊
- Organizer
  International Union of Microbiological Societies 2011 Congress
- Place of Presentation
  札幌コンベンションセンター(北海道)
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] 腸管出血性大腸菌NO reductaseは志賀毒素2の産生を増加させる2011
- Author(s)
  清水健、津々木博康、野田公俊
- Organizer
  第58回トキシンシンポジウム
- Place of Presentation
  順天堂大学(東京)(招待講演)
- Year and Date
  2011-07-06
- Data Source
  KAKENHI-PROJECT-21590478
[Presentation] 腸管出血性大腸菌の産生する新規SubABトキシンによるNO産生抑制機構の解明2011
- Author(s)
  津々木博康, 八尋錦之助, 清水健, 野田公俊
- Organizer
  第58回トキシンシンポジウム
- Place of Presentation
  東京
- Year and Date
  2011-07-06
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] 腸管出血性大腸菌の産生する志賀毒素について2011
- Author(s)
  清水健
- Organizer
  緊急セミナー:腸管出血性大腸菌の今
- Place of Presentation
  東京、東京慈恵会医科大学(招待講演)
- Year and Date
  2011-08-02
- Data Source
  KAKENHI-PROJECT-21590478
[Presentation] 野田公俊腸管出血性大腸菌のNO reductaseは志賀毒素2の産生を増加させる2011
- Author(s)
  清水健, 津々木博康
- Organizer
  第58回トキシンシンポジウムシンポジウム指名講演
- Place of Presentation
  東京、順天堂大学
- Data Source
  KAKENHI-PROJECT-21590478
[Presentation] 腸管出血性大腸菌の産生する新規SubABトキシンによるNO産生抑制機構の解明2011
- Author(s)
  津々木博康、八尋錦之助、清水健、野田公俊
- Organizer
  第58回トキシンシンポジウム
- Place of Presentation
  順天堂大学(東京)(招待講演)
- Year and Date
  2011-07-06
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] Subtilase cytotoxin inhibits the production of nitric oxide from macrophage2011
- Author(s)
  津々木博康、八尋錦之助、清水健、野田公俊
- Organizer
  International Union of Microbiological Societies 2011 Congress
- Place of Presentation
  札幌コンベンションセンター(北海道)
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] Subtilase cytotoxin produced by Escherichia coli induces fatal hemorrhage in mice2011
- Author(s)
  八尋錦之助、古川健、寺崎泰弘、辻厚至、清水健、盛永直子、野田公俊
- Organizer
  46^<th> US-Japan Cholera and Other Bacterial Enteric Infections Joint Panel Meeting
- Place of Presentation
  インド
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] Haruaki Nakaya and Masatoshi Noda The nitric oxide reductase of enterohemorrhagic Escherichia coliO157:H7 increases Shiga toxin 2 production andplays an important role in its infection2011
- Author(s)
  Takeshi Shimizu, Hiroyasu Tsutsuki, Akio Matsumoto
- Organizer
  46^<th> Joint Conference on Cholera and Other Bacterial Enteric Infections Panel
- Place of Presentation
  Kolkata, India
- Data Source
  KAKENHI-PROJECT-21590478
[Presentation] 腸管出血性大腸菌が産生するSubtilase cytotoxinはマクロファージのNO産生を抑制する2011
- Author(s)
  津々木博康, 八尋錦之助, 清水健, 野田公俊
- Organizer
  第96回日本細菌学会関東支部総会
- Place of Presentation
  東京
- Year and Date
  2011-10-06
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] 清水健腸管出血性大腸菌の産生する志賀毒素について2011
- Author(s)
  清水健
- Organizer
  緊急セミナー:腸管出血性大腸菌の今
- Place of Presentation
  東京、東京慈恵会医科大学
- Data Source
  KAKENHI-PROJECT-21590478
[Presentation] 腸管出血性大腸菌の産生する新規SubABトキシンによるNO産生抑制機構の解明2010
- Author(s)
  津々木博康, 八尋錦之助, 清水健, 野田公俊
- Organizer
  インターラボセミナー
- Place of Presentation
  千葉
- Year and Date
  2010-12-11
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] 腸管上皮細胞に接着した腸管出血性大腸菌はその志賀毒素1の産生量を増加させる2010
- Author(s)
  清水健, 野田公俊
- Organizer
  第83回日本細菌学会総会
- Place of Presentation
  横浜、パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-21590478
[Presentation] Adherent effects of enterohemorrahgic Escherichia coli to human intestinal epithelial cells on its Shiga toxins production2010
- Author(s)
  Takeshi Shimizu Masatoshi Noda
- Organizer
  45^<th> Joint Conference on Cholera and OtherBacterial Enteric Infections Panel
- Place of Presentation
  Kyoto University, Kyoto
- Data Source
  KAKENHI-PROJECT-21590478
[Presentation] Adherent effects of enterohemorrahgic Escberichia coli to human intestinal epithelial cells on its Shiga toxins production2010
- Author(s)
  Takeshi Shimizu
- Organizer
  45^<th> Joint Conference on Cholera and Other Bacterial Enteric Infections Panel
- Place of Presentation
  Kyoto University, Kyoto
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-21590478
[Presentation] Adherence of EHEC to Caco-2 cells induces the increase of Stx1 production2010
- Author(s)
  清水健, 野田公俊
- Organizer
  第83回日本細菌学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] 腸管出血性大腸菌の腸管上皮細胞への接着は病原因子の発現を増加させる2010
- Author(s)
  清水健
- Organizer
  第57回トキシンシンポジウムシンポジウム
- Place of Presentation
  長浜、長浜ロイヤルホテル指名講演
- Year and Date
  2010-07-15
- Data Source
  KAKENHI-PROJECT-21590478
[Presentation] 腸管出血性大腸菌の腸管上皮細胞への接着は病原因子の発現を増加させる2010
- Author(s)
  清水健, 野田公俊
- Organizer
  第57回トキシンシンポジウムシンポジウム指名講演
- Place of Presentation
  長浜、長浜ロイヤルホテル
- Data Source
  KAKENHI-PROJECT-21590478
[Presentation] Effect of phage-inducing agent on the number of Stx2-expressed cells in Shiga toxin-producing Escherichia coli2009
- Author(s)
  清水健, 野田公俊
- Organizer
  44th US-Japan Cholera and Other Bacterial Enteric Infections Joint Panel Meeting
- Place of Presentation
  サンディエゴ、USA
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] Effect of phage-inducing agent on the number of Stx2-expressed cells in Shiga toxin-producing Escherichia coli.2009
- Author(s)
  Takeshi Shimizu
- Organizer
  44^<rd> Joint Conference on Cholera and Other Bacterial Enteric Infections Panel
- Place of Presentation
  San Diego, California
- Data Source
  KAKENHI-PROJECT-21590478
[Presentation] 腸管出血性大腸菌には志賀毒素2に対する2種類の特異的な放出機構がある2009
- Author(s)
  清水健、野田公俊
- Organizer
  第82回日本細菌学会総会
- Place of Presentation
  名古屋、名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-19590440
[Presentation] 腸管出血性大腸菌には志賀毒素2に対する2種類の特異的な放出機構がある2009
- Author(s)
  清水健
- Organizer
  第82回日本細菌学会総会
- Place of Presentation
  名古屋, 名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-19590440
[Presentation] 腸管出血性大腸菌が産生する志賀毒素2の菌体外放出機構の解析2009
- Author(s)
  清水健, 野田公俊
- Organizer
  第56回トキシンシンポジウムシンポジウム指名講演
- Place of Presentation
  岐阜、アルモニーテラッセ
- Data Source
  KAKENHI-PROJECT-21590478
[Presentation] 腸管出血性大腸菌が産生する志賀毒素の菌体外放出機構2009
- Author(s)
  清水健
- Organizer
  第92回日本細菌学会関東支部総会シンポジウム
- Place of Presentation
  東京、東京医科歯科大学
- Data Source
  KAKENHI-PROJECT-21590478
[Presentation] Effect of phage-inducing agent on the number of Stx2-expressed cells in Shiga toxin-producing Escherichia coli2009
- Author(s)
  Takeshi Shimizu, Yuko Ohta Masatoshi Noda
- Organizer
  44^<rd> Joint Conference on Cholera and OtherBacterial Enteric Infections Panel
- Place of Presentation
  San Diego, California
- Data Source
  KAKENHI-PROJECT-21590478
[Presentation] A mechanism of Stx2 release from enterohemorrahgic Escherichia coli2009
- Author(s)
  Takeshi Shimizu, Yuko Ohta Masatoshi Noda
- Organizer
  The 13^<th> International Conference on EmergingInfectious Diseases in the Pacific Rim
- Place of Presentation
  Kolkata, India
- Data Source
  KAKENHI-PROJECT-21590478
[Presentation] A mechanism of Stx2 release from enterohemorrahgic Escherichia coli2009
- Author(s)
  Takeshi Shimizu
- Organizer
  The 13^<th> International Conference on Emerging Infectious Diseases in the Pacific Rim
- Place of Presentation
  Kolkata, India
- Data Source
  KAKENHI-PROJECT-21590478
[Presentation] 志賀様毒素2の分泌にはBサブユニットの特定のアミノ酸残基の側鎖が重要である2008
- Author(s)
  清水健
- Organizer
  日本細菌学会
- Place of Presentation
  国際会議場・京都
- Year and Date
  2008-03-24
- Data Source
  KAKENHI-PROJECT-19590440
[Presentation] 志賀毒素2の分泌にはBサブユニットの特定のアミノ酸残基の側鎖が重要である2008
- Author(s)
  清水健、佐藤壽男、濱端崇、野田公俊
- Organizer
  第81回日本細菌学会総会
- Place of Presentation
  京都、国立京都国際会館
- Data Source
  KAKENHI-PROJECT-19590440
[Presentation] A mechanism of Stx2 release from enterohemorrahgic Escherichia coli by a non-secretion system2008
- Author(s)
  Takeshi Shimizu, Yuko Ohta and Masatoshi Noda
- Organizer
  43^<rd> Joint Conference on Cholera and Other Bacterial Enteric Infections Panel
- Place of Presentation
  Centennial Hall in Kyushu University, Fukuoka
- Data Source
  KAKENHI-PROJECT-19590440
[Presentation] Binding mode of chimera Shiga toxins and their toxicity2007
- Author(s)
  Takeshi Shimizu, Toshio Sato, Takashi Hamabata and Masatoshi Noda
- Organizer
  42^<nd> Joint Conference on Cholera and Other Bacterial Enteric Infections Panel
- Place of Presentation
  Austin, Texas
- Data Source
  KAKENHI-PROJECT-19590440
[Presentation] Binding mode of chimera Shiga toxins and their toxicity2007
- Author(s)
  Takeshi Shimizu
- Organizer
  42ndJoint Conference on Cholera and Other Bacterial Enteric Infections Panel
- Place of Presentation
  Austin,Texas
- Data Source
  KAKENHI-PROJECT-19590440
[Presentation] 腸管出血性大腸菌の接着を認識する病原因子発現機構の解析
- Author(s)
  清水　健、市村公敏、野田公俊
- Organizer
  第１８回腸管出血性大腸菌感染症研究会
- Place of Presentation
  同志社大学室町キャンパス、京都府、京都市
- Year and Date
  2014-07-15 – 2014-07-16
- Data Source
  KAKENHI-PROJECT-26670208
[Presentation] The surface sensor NlpE of enterohemorrhagic Escherichia coli contributes to the regulation of virulence factors via adherence of bacteria to Caco-2 cells
- Author(s)
  Takeshi Shimizu, Kimitoshi Ichimura and Masatoshi Noda
- Organizer
  49th Joint Conference on Cholera and Other Bacterial Enteric Infections Panel
- Place of Presentation
  Gainesville, Florida, USA
- Year and Date
  2015-01-14 – 2015-01-16
- Data Source
  KAKENHI-PROJECT-26670208
[Presentation] 腸管出血性大腸菌のsurface sensor NlpEは接着時にCpx経路によって病原因子の発現を調節する
- Author(s)
  清水　健、市村公敏、野田公俊
- Organizer
  第８８回　日本細菌学会総会
- Place of Presentation
  長良川国際会議場、岐阜県、岐阜市
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26670208

1. NODA Masatoshi (60164703)

# of Collaborated Projects: 7 results

# of Collaborated Products: 56 results
2. MORINAGA Naoko (20092108)

# of Collaborated Projects: 5 results

# of Collaborated Products: 1 results
3. HAMABATA Takashi (40311427)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
4. KUWABARA Satoshi (70282481)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. MORI Masahiro (70345023)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. YAHIRO Kinnosuke (80345024)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
7. TSUTSUKI Hiroyasu (40586608)

# of Collaborated Projects: 2 results

# of Collaborated Products: 19 results
8. MATSUMOTO Akio (60437308)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. OZAWA Kentaro (80507393)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. MATSUMOTO Ayako (60444519)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. NAKAYA Haruaki (60113594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. NABEYA Yoshihiro (40322028)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 小倉康平 (00586612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. 落合武徳 (80114255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. ENDO Hidemi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SUTO Akira

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. SUZUKI Kotaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 伊豫田淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 中島裕史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shimizu Takeshi 清水 健

SHIMIZU Takeshi 清水 健

清水 健 シミズ タケシ

Research Projects

Research Products

Co-Researchers

RNA結合タンパク質依存的なRNA-RNA相互作用を介した新規ストレス応答増強機構の解明Principal Investigator

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Identification and functional analysis of resistance factors for enterohemorrhagic Escherichia coli-specific defense mechanismsPrincipal Investigator

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A study on the acquisition mechanism of pathogenicity in intact NO reductase-type EHECPrincipal Investigator

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Establishment of absolute anaerobic biology for pathogenic evaluation of EHECPrincipal Investigator

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Elucidation of the pathogenic reinforcement action of enterohemorrhagic Escherichia coli produced SubAB

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Elucidation of Shiga-toxigenic Escherichia coli produced Subtilase cytotoxin-induced cell damage mechanism.

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Study of Shiga toxin productions us ing in vivo analysisPrincipal Investigator

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Explication of the regulatory mechanism of S-nitrosylation signaling

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Studies on the SubAB toxin, its target organs, and its quick identification

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Analysis of secretion system of virulence factor in gram-negative bacteriaPrincipal Investigator

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Elucidation of a potential role of poly-ADP-ribosylation in the carcinogenesis or development of human colorectal carcinoma and its application for the diagnosis or trteatment of human colorectal carcinoma

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Study on the virulence factors of enterohemorrhagic Escherichia coliPrincipal Investigator

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病原細菌における病原因子の機能的検索法の開発Principal Investigator

Principal Investigator

Shimizu Takeshi 清水健

SHIMIZU Takeshi 清水健

清水健シミズタケシ