Yoshioka Kenichi 吉岡研一

… Alternative Names

Yoshioka Ken-ichi 吉岡研一

YOSHIOKA Ken-ichi 吉岡研一

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Researcher Number	70321916
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立がん研究センター, 研究所, ユニット長
Affiliation (based on the past Project Information) *help	2021 – 2023: 国立研究開発法人国立がん研究センター, 研究所, ユニット長 2009: Tokyo Medical and Dental University, 研究所, 主任研究官 2009: National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East, 研究所, 主任研究官 2007 – 2008: Tokyo Medical and Dental University, Medical Research Institute, Assistant Professor
Review Section/Research Field	Principal Investigator Basic Section 63020:Radiation influence-related / Molecular biology Except Principal Investigator General surgery / Cell biology
Keywords	Principal Investigator 発がん / ゲノム不安定性 / がん / UV / エピゲノム / 複製ストレス / DNA損傷 / 紫外線 / 放射線 / H2AX … More / 加齢 / ミスマッチ修復因子 / NDA損傷 / DNA複製ストレス / クロモソーマル不安定性 / DNA複製 / マイクロサテライト不安定性 / ミスマッチ修復 … More Except Principal Investigator 再生医療 / ES細胞 / iPS cell / ex utero surgery / Hepatoblast / Bile duct / Cell transplantation / Regenerative medicine / Hepatocyte / ES cell / 肝外胆管 / 肝機能障害治療 / iPS細胞 / ex utero移植法 / 肝芽細胞 / 胆管 / 細胞移植 / 肝細胞 / 霊長類 / 再生医学 / DNA2重鎖切断 / 霊長瀬 / ゲノム安定化 / DNA損傷応答 / DNA修復 Less

Study of genomic instability risk arisen by UV and ionizing radiationPrincipal Investigator
- Principal Investigator
  
  Yoshioka Ken-ichi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  National Cancer Center Japan
Regulations of mismatch repair proteins for cancer preventionPrincipal Investigator
- Principal Investigator
  
  YOSHIOKA Ken-ichi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  Tokyo Medical and Dental University
胚性幹(ES)細胞におけるDNA二重鎖切断修復の特徴
- Principal Investigator
  
  TERAOKA Hirobumi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cell biology
- Research Institution
  Tokyo Medical and Dental University
Studies of regenerative medicine on differentiation into hepatic and bile duct cells for preclinical trial to surgery
- Principal Investigator
  
  TERAOKA Hirobumi, 寺本研一
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Tokyo Medical and Dental University

All 2024 2023 2022 2021 2010 2008

All Journal Article Presentation

[Journal Article] Single base substitution signatures 17a, 17b, and 40 are induced by γ-ray irradiation in association with increased reactive oxidative species2024
- Author(s)
  Manaka Yuya、Kusumoto-Matsuo Rika、Matsuno Yusuke、Asai Haruka、Yoshioka Ken-ichi
- Journal Title
  
  Heliyon
  
  Volume: 10 Issue: 6 Pages: e28044-e28044
- DOI
  10.1016/j.heliyon.2024.e28044
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K12252, KAKENHI-PROJECT-22KJ3157
[Journal Article] Genome Destabilization-Associated Phenotypes Arising as a Consequence of Therapeutic Treatment are Suppressed by Olaparib2023
- Author(s)
  Suzuki M., Fujimori H., Wakatsuki K., Manaka Y., Asai H., Hyodo M., Matsuno Y., Kusumoto-Matsuo R., Shiroishi M. and Yoshioka K.
- Journal Title
  
  PLoS One
  
  Volume: 18 Issue: 1 Pages: e0281168-e0281168
- DOI
  10.1371/journal.pone.0281168
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KJ3157, KAKENHI-PROJECT-20K12159, KAKENHI-PROJECT-21K12252
[Journal Article] Echoed induction of nucleotide variants and chromosomal structural variants in cancer cells2022
- Author(s)
  Matsuno Yusuke、Kusumoto-Matsuo Rika、Manaka Yuya、Asai Haruka、Yoshioka Ken-ichi
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 20964-20964
- DOI
  10.1038/s41598-022-25479-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K12252, KAKENHI-PROJECT-21J12419, KAKENHI-PROJECT-22KJ3157, KAKENHI-PROJECT-20K12159
[Journal Article] Genomic Instability and Cancer Risk Associated with Erroneous DNA Repair.2021
- Author(s)
  Yoshioka KI, Kusumoto-Matsuo R, Matsuno Y, Ishiai M.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 22 Issue: 22 Pages: 12254-12254
- DOI
  10.3390/ijms222212254
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11642, KAKENHI-PROJECT-20K12159, KAKENHI-PROJECT-21K12252, KAKENHI-PROJECT-22KJ3157
[Journal Article] Replication-stress-associated DSBs induced by ionizing radiation risk genomic destabilization and associated clonal evolution.2021
- Author(s)
  Matsuno Y, Hyodo M, Suzuki M, Tanaka Y, Horikoshi Y, Murakami Y, Torigoe H, Mano H, Tashiro S, Yoshioka KI.
- Journal Title
  
  iScience.
  
  Volume: 24 Issue: 4 Pages: 102313-102313
- DOI
  10.1016/j.isci.2021.102313
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04927, KAKENHI-PROJECT-21J12419, KAKENHI-PROJECT-21K12252
[Journal Article] DNA Lesions Induced by Replication Stress Trigger Mitotic Aberration and Tetraploidy Development.2010
- Author(s)
  Ichijima, Y., Yoshioka, K., * Yoshioka, Y., Shinohe, K., Fujimori, H., Unno, J., Takagi, M., Goto, H., Inagaki, I., Mizutani, S., Teraoka, H.
- Journal Title
  
  PLoS ONE 5
- Data Source
  KAKENHI-PROJECT-20770136
[Journal Article] The Mismatch Repair-Mediated Cell Cycle Checkpoint Response to Fluorodeoxyuridine2008
- Author(s)
  Liu, A., Yoshioka, K., Salerno, V., & Hsieh, P.
- Journal Title
  
  J. Cellular Biochem 105
  
  Pages: 245-254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770136
[Journal Article] The Mismatch Repair-Mediated Cell Cycle Checkpoint Response to Fluorodeoxyuridine.2008
- Author(s)
  Liu, A., Yoshioka, K., Salerno, V., Hsieh, P.
- Journal Title
  
  J Cellular Biochem 105
  
  Pages: 245-254
- Data Source
  KAKENHI-PROJECT-20770136
[Presentation] ゲノム安定性制御を作用点としたがん予防への挑戦2021
- Author(s)
  吉岡研一
- Organizer
  日本抗加齢医学会
- Invited
- Data Source
  KAKENHI-PROJECT-21K12252
[Presentation] 放射線で誘導される複製ストレスに起因したゲノム不安定性リスクとこれに伴うクローン進化2021
- Author(s)
  吉岡研一
- Organizer
  放射線影響学会
- Data Source
  KAKENHI-PROJECT-21K12252
[Presentation] 老化細胞の形質転換は、H2AXの減少-DNA修復能の低下-DNA損傷の蓄積DNAの傷のM期への進行-ゲノム不安定化を経由して誘導される2008
- Author(s)
  吉岡研一
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-20770136
[Presentation] 老化細胞の形質転換は、H2AXの減少-DNA修復能の低下-DNA損傷の蓄積-DNAの傷のM期への進行-ゲノム不安定化を経由して誘導される2008
- Author(s)
  吉岡研一
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-20770136

1. TERAOKA Hirobumi (30019137)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. 朝比奈欣治 (40345294)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 斉藤佳子 (50178969)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. ARII Shigeki (50151171)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TANAKA Yujiro (70236644)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. ISEKI Sachiko (80251544)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TAKASE Kozo (90211333)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 寺本研一 (80197813)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SUN Jying

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 石合正道

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 田代聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 堀越保則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yoshioka Kenichi 吉岡 研一

Yoshioka Ken-ichi 吉岡 研一

YOSHIOKA Ken-ichi 吉岡 研一

Research Projects

Research Products

Co-Researchers

Study of genomic instability risk arisen by UV and ionizing radiationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulations of mismatch repair proteins for cancer preventionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

胚性幹(ES)細胞におけるDNA二重鎖切断修復の特徴

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies of regenerative medicine on differentiation into hepatic and bile duct cells for preclinical trial to surgery

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Single base substitution signatures 17a, 17b, and 40 are induced by γ-ray irradiation in association with increased reactive oxidative species2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genome Destabilization-Associated Phenotypes Arising as a Consequence of Therapeutic Treatment are Suppressed by Olaparib2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Echoed induction of nucleotide variants and chromosomal structural variants in cancer cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genomic Instability and Cancer Risk Associated with Erroneous DNA Repair.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Replication-stress-associated DSBs induced by ionizing radiation risk genomic destabilization and associated clonal evolution.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DNA Lesions Induced by Replication Stress Trigger Mitotic Aberration and Tetraploidy Development.2010

Author(s)

Journal Title

Data Source

[Journal Article] The Mismatch Repair-Mediated Cell Cycle Checkpoint Response to Fluorodeoxyuridine2008

Author(s)

Journal Title

Data Source

[Journal Article] The Mismatch Repair-Mediated Cell Cycle Checkpoint Response to Fluorodeoxyuridine.2008

Author(s)

Journal Title

Data Source

[Presentation] ゲノム安定性制御を作用点としたがん予防への挑戦2021

Author(s)

Organizer

Data Source

[Presentation] 放射線で誘導される複製ストレスに起因したゲノム不安定性リスクとこれに伴うクローン進化2021

Author(s)

Organizer

Data Source

[Presentation] 老化細胞の形質転換は、H2AXの減少-DNA修復能の低下-DNA損傷の蓄積DNAの傷のM期への進行-ゲノム不安定化を経由して誘導される2008

Author(s)

Organizer

Place of Presentation

Year and Date

Yoshioka Kenichi 吉岡研一

Yoshioka Ken-ichi 吉岡研一

YOSHIOKA Ken-ichi 吉岡研一