ISHIKAWA Tomoo 石川智夫

Researcher Number	70322162
External Links
Affiliation (based on the past Project Information) *help	2011 – 2014: 金沢大学, がん進展制御研究所, 助教 2010: 金沢大学, がん研究所, 助教 2000 – 2002: 京都大学, 医学研究科, 助手
Review Section/Research Field	Principal Investigator Tumor biology / Carcinogenesis Except Principal Investigator Laboratory animal science / Biological Sciences / Carcinogenesis / Biological Sciences / Experimental pathology
Keywords	Principal Investigator 炎症 / マウスモデル / がん / 癌 / 転移 Except Principal Investigator COX-2 / マウスモデル / 炎症 / 胃がん / トランスジェニックマウス … More / opti-rtTA / TRE / rtTA / APC / 自然免疫 / TGF-beta / PGE_2 / マクロファージ / LKB1 / マイクロアレイ / COX-2 Transeenics / doxycycline / tetracycline / conditional / transgenic mice / ES細胞 / ドキシサイクリン / テトラサイクリン / コンディショナル / LKB 1 / Pathology / Cancer / Transgenic mouse / Stromal cells / Prostaglandin / EP2 / cPLA2 / ポリープ / β-catenin / Smad2 / 血管新生 / ノックアウトマウス / 肝癌 / 大腸癌 / TGF-βシグナル / 線維芽細胞 / Fhit / Lkb1 / Apc / 病理学 / 癌 / 間質細胞 / プロスタグランジン / 腫瘍免疫 / 微小環境 / TNF-α / 消化器がん / 発がん / 感染 / PGE2 / mPGES / LYVE-1 / リンパ管新生 / B16F10 / mTOR / Cdx2 / プロテオミクス / 染色体不安定性 / Wnt / CDX2 / CCL9 / CCR1 / CXCR3 / ケモカイン / 同所移植 / 浸潤 / 転移 Less

The role of inflammatory responses and tumor immunity in tumor development
- Principal Investigator
  
  OSHIMA Masanobu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Carcinogenesis
- Research Institution
  Kanazawa University
炎症による上皮細胞分化制御の二面性と腫瘍形成機構への関与Principal Investigator
- Principal Investigator
  
  石川智夫
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Kanazawa University
Gastrointestinal tumorigenesis by cooperation of oncogenic activation and inflammatory responses
- Principal Investigator
  
  OSHIMA Masanobu
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kanazawa University
Research of the mechanisms of progression and metastasis using mouse gastrointestinal cancer modelsPrincipal Investigator
- Principal Investigator
  
  ISHIKAWA Tomo-o
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Carcinogenesis
- Research Institution
  Kanazawa University
Gastric tumorigenesis through cooperation of COX-2/PGE2 pathway and inflammatory responses
- Principal Investigator
  
  OSHIMA Masanobu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Kanazawa University
消化器癌の転移機構とその治療の研究
- Principal Investigator
  
  TAKETO Makoto Mark
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Creative Scientific Research
- Research Institution
  Kyoto University
時期特異的な全身性遺伝子発現誘導トランスジェニックマウスシステムの開発
- Principal Investigator
  
  OSHIMA Masanobu
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  KYOTO UNIVERSITY
Epithelium-stroma interactions in carcinogenesis
- Principal Investigator
  
  TAKETO Makoto Mark
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  KYOTO UNIVERSITY

All 2014 2013 2012 2011 2010 2003 2001 Other

All Journal Article Presentation Patent

[Journal Article] Context-dependent activation of Wnt signaling by tumor suppressor RUNX3 in gastric cancer cells2014
- Author(s)
  Ju X, Ishikawa T, Naka K, et al.
- Journal Title
  
  Cancer Science
  
  Volume: 105 Issue: 4 Pages: 418-424
- DOI
  10.1111/cas.12356
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22114005, KAKENHI-PROJECT-24300325, KAKENHI-PROJECT-26290040
[Journal Article] TNF-a/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells2014
- Author(s)
  Oshima H, Ishikawa T, Yoshida GJ, et al.
- Journal Title
  
  Oncogene
  
  Volume: 33 Issue: 29 Pages: 3820-3829
- DOI
  10.1038/onc.2013.356
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22114005, KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24300325, KAKENHI-PROJECT-24501314, KAKENHI-PROJECT-25430107, KAKENHI-PROJECT-25670572
[Journal Article] Inflammation-induced repression of tumor suppressor miR-7 in gastric tumor cells2012
- Author(s)
  Kong D, Piao YS, Yamashita S, Oshima H, Oguma K, Fushida S, Fujimura T, Minamoto T, Seno H, Yamada Y, Satou K, Ushijima T, Ishikawa T, and Oshima M.
- Journal Title
  
  Oncogene
  
  Volume: (in press) Issue: 35 Pages: 3949-60
- DOI
  10.1038/onc.2011.558
- NAID
  120003779577
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390118, KAKENHI-PLANNED-22114005, KAKENHI-PROJECT-22249051, KAKENHI-PROJECT-22500996, KAKENHI-PROJECT-22800025, KAKENHI-PROJECT-23659643, KAKENHI-PROJECT-24300325
[Journal Article] Cox-2 deletion in myeloid and endothelial cells, but not in epithelialcells2011
- Author(s)
  Ishikawa, T., Oshima, M. and Herschman, H. R.
- Journal Title
  
  Carcinogenesis
  
  Volume: 32 Issue: 3 Pages: 417-426
- DOI
  10.1093/carcin/bgq268
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22800025
[Journal Article] Prostaglandin E_2 signaling and bacterial infection recruit tumor-promoting macrophages to mouse gastric tumors2011
- Author(s)
  Oshima H, Hioki K, Popivanova BK, Oguma K, van Rooijen N, Ishikawa T, and Oshima M.
- Journal Title
  
  Gastroenterology
  
  Volume: 140 Issue: 2 Pages: 596-607
- DOI
  10.1053/j.gastro.2010.11.007
- NAID
  120002829318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390118, KAKENHI-PROJECT-22500996, KAKENHI-PROJECT-22800025
[Journal Article] Activation of epidermal growth factor receptor signaling by the prostaglandin E_2 receptor EP4 pathway during gastric tumorigenesis2011
- Author(s)
  Oshima H, Popivanova BK, Oguma K, Kong D, Ishikawa T, and Oshima M.
- Journal Title
  
  Cancer Sci
  
  Volume: 102 Issue: 4 Pages: 713-719
- DOI
  10.1111/j.1349-7006.2011.01847.x
- NAID
  10029291933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390118, KAKENHI-PLANNED-22114005, KAKENHI-PROJECT-22500996, KAKENHI-PROJECT-22800025
[Journal Article] Requirement for tumor suppressor Apc in the morphogenesis of anterior and ventral mouse embryo.2003
- Author(s)
  T.Ishikawa
- Journal Title
  
  Developmental Biology 253巻・2号
  
  Pages: 230-246
- Data Source
  KAKENHI-PROJECT-14GS0316
[Journal Article] Requirement for tumor suppressor Apc in the morphogenesis of anterior and ventral mouse embryo.2003
- Author(s)
  Ishikawa, T.et al.
- Journal Title
  
  Developmental Biology 253・2
  
  Pages: 230-246
- Data Source
  KAKENHI-PROJECT-12219203
[Journal Article] Requirement for tumor suppressor Ape in the morphogenesis of anterior and ventral mouse embryo.2003
- Author(s)
  Ishikawa TO et al.
- Journal Title
  
  Developmental Biology 253
  
  Pages: 230-246
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12219203
[Journal Article] Requirement for tumor suppressor Apc in the morphogenesis of anterior and ventral mouse embryo.2003
- Author(s)
  Ishikawa, TO et al.
- Journal Title
  
  Developmental Biology 253(2)
  
  Pages: 230-46
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12219203
[Journal Article] Mouse Wnt receptor gene Fzd5 essential for yolk sac and placental angiogenesis.2001
- Author(s)
  Ishikawa, T.et al.
- Journal Title
  
  Development 128・1
  
  Pages: 25-33
- Data Source
  KAKENHI-PROJECT-12219203
[Journal Article] Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis.2001
- Author(s)
  Ishikawa T et al.
- Journal Title
  
  Development 128
  
  Pages: 25-33
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12219203
[Journal Article] Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis.2001
- Author(s)
  Ishikawa, T et al.
- Journal Title
  
  Development 128(1)
  
  Pages: 25-33
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12219203
[Journal Article] Imaging Cyclooxygenase-2(Cox-2)Gene Expression in Living Animals with a Luciferase Knock-in Reporter Gene.
- Author(s)
  Ishikawa TO et al.
- Journal Title
  
  Mol.Imaging Biol. (In press)
- Data Source
  KAKENHI-PROJECT-14GS0316
[Patent] がんの予防用または治療用物質のスクリーニング方法2013
- Inventor(s)
  大島正伸、大島浩子、石川智夫
- Industrial Property Rights Holder
  大島正伸、大島浩子、石川智夫
- Industrial Property Rights Type
  特許
- Filing Date
  2013-03-20
- Data Source
  KAKENHI-PLANNED-22114005
[Patent] がんの予防用または治療用物質のスクリーニング方法2013
- Inventor(s)
  大島正伸、大島浩子、石川智夫
- Industrial Property Rights Holder
  大島正伸、大島浩子、石川智夫
- Filing Date
  2013-02-20
- Data Source
  KAKENHI-PROJECT-24300325
[Patent] がんの予防用または治療用物質のスクリーニング法2013
- Inventor(s)
  大島正伸、石川智夫、大島浩子
- Industrial Property Rights Holder
  大島正伸、石川智夫、大島浩子
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-030503
- Filing Date
  2013-02-20
- Data Source
  KAKENHI-PROJECT-24501314
[Presentation] Wnt activation by RUNX3 in Kato-III gastric cancer cells2013
- Author(s)
  Ju X, Ishikawa T, Oshima H, Ito K, Ito Y, Oshima M.
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-24300325
[Presentation] Gastric tumorigenesis by activation of tumor necrosis factor-alpha signaling in bone marrow derived cells2013
- Author(s)
  Ishikawa, T.
- Organizer
  第８回研究所ネットワーク国際シンポジウム
- Place of Presentation
  京都大学芝蘭会館（京都府京都市）
- Data Source
  KAKENHI-PROJECT-24501314
[Presentation] Wnt activation by RUNX3 in Kato-III gastric cancer cells2013
- Author(s)
  Ju X, Ishikawa T, Oshima H, Ito K, Ito Y, Oshima M.
- Organizer
  第72回　日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PLANNED-22114005
[Presentation] Effects of inflammation on the epithelial differentiation and tumorigenesis2012
- Author(s)
  Ishikawa, T. and Oshima, M.
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌、ホテル札幌芸文館、札幌市教育文化会館（北海道）
- Data Source
  KAKENHI-PROJECT-24501314
[Presentation] The role of inflammatory cytokine TNF in CD44 expression-associated mouse gastric tumorigenesis2012
- Author(s)
  Oshima H, Yoshida GJ, Ishikawa T, Saya H, Oshima M
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌（北海道）
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PLANNED-22114005
[Presentation] Effects of inflammation on the epithelial differentiation and tumorigenesis2012
- Author(s)
  Ishikawa T, Oshima M
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌（北海道）
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PLANNED-22114005
[Presentation] The role of TNF-α in PGE2-induced tumorigenesis in gastric cancer mouse model2012
- Author(s)
  Oshima H, Ishikawa T, and Oshima M
- Organizer
  103th AACR Annual Meeting
- Place of Presentation
  McCormick Place West (シカゴ)
- Year and Date
  2012-04-01
- Data Source
  KAKENHI-PLANNED-22114005
[Presentation] Effects of inflammatin on the epithelial differentiation and tumorigenesis2011
- Author(s)
  Ishikawa T, and Oshima M.
- Organizer
  16^<th> Japan-Korea Cancer Research Workshop
- Place of Presentation
  北海道大学(北海道)
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PROJECT-21390118
[Presentation] Cox-2 deletion in myeloid and endothelial cells, but not in epithelial cells, exacerbates murine colitis2011
- Author(s)
  Ishikawa T, and Oshima M.
- Organizer
  70^<th> Annual Meeting for Japanese Cancer Association
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-21390118
[Presentation] Effects of inflammation on the epithelial differentiation and tumorigenesis2011
- Author(s)
  Ishikawa, T. and Oshima, M
- Organizer
  16th Japan-Korea Cancer Research Workshop
- Place of Presentation
  北海道大学(北海道)
- Year and Date
  2011-12-09
- Data Source
  KAKENHI-PROJECT-22800025
[Presentation] Effects of inflammation on the epithelial differentiation and tumorigenesis2011
- Author(s)
  Ishikawa, T. and Oshima, M.
- Organizer
  70th Annual Meeting for Japanese cancer
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-22800025
[Presentation] Effects of inflammation on the epithelial differentiation and tumorigenesis2011
- Author(s)
  石川智夫
- Organizer
  The 16^<th> Korea-Japan Cancer Research Workshop
- Place of Presentation
  京王プラザホテル札幌(北海道)
- Year and Date
  2011-12-09
- Data Source
  KAKENHI-PROJECT-22800025
[Presentation] Effects of inflammation on the epithelial differentiation and tumorigenesis2011
- Author(s)
  Ishikawa T, Oshima M
- Organizer
  16^<th> Japan-Korea Cancer Research Workshop
- Place of Presentation
  北海道大学(北海道)
- Data Source
  KAKENHI-PLANNED-22114005
[Presentation] Cox-2 deletion in myeloid and endothelial cells, but not in epithelial cells, exacerbates murine colitis2011
- Author(s)
  石川智夫
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-22800025
[Presentation] Cox-2 deletion in myeloid and endothelial cells, but not in epithelial cells, exacerbates murine colitis2011
- Author(s)
  Ishikawa T, Oshima M.
- Organizer
  70^<th> Annual Meeting for Japanese Cancer Association
- Place of Presentation
  名古屋国際会議場(愛知)
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PLANNED-22114005
[Presentation] Tumorformation without Cyclooxygenase-2(Cox-2) expression in mouse model ofcolitis-associated cancer2010
- Author(s)
  Ishikawa, T. and Oshima, M
- Organizer
  69Th Annua lMeeting for Japanese Cancer Association
- Place of Presentation
  大阪国際会議場(大阪府)
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22800025
[Presentation] Tumor formation without Cyclooxygenase-2(Cox-2)expression in mouse model of colitis associated cancer2010
- Author(s)
  石川智夫
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪府)
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22800025

1. OSHIMA Masanobu (40324610)

# of Collaborated Projects: 6 results

# of Collaborated Products: 13 results
2. TAKETO Makoto Mark (70281714)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. OSHIMA Hiroko (80362515)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
4. AOKI Masahiro (60362464)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. MIYOSHI Hiroyuki (30362479)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. KITAMURA Takanori (10378622)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 高久和明 (90313121)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. NAKAYAMA Mizuho (20398225)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

ISHIKAWA Tomoo 石川 智夫

Research Projects

Research Products

Co-Researchers

The role of inflammatory responses and tumor immunity in tumor development

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

炎症による上皮細胞分化制御の二面性と腫瘍形成機構への関与Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Gastrointestinal tumorigenesis by cooperation of oncogenic activation and inflammatory responses

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research of the mechanisms of progression and metastasis using mouse gastrointestinal cancer modelsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Gastric tumorigenesis through cooperation of COX-2/PGE2 pathway and inflammatory responses

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

消化器癌の転移機構とその治療の研究

Principal Investigator

Project Period (FY)

Research Category

Research Institution

時期特異的な全身性遺伝子発現誘導トランスジェニックマウスシステムの開発

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Epithelium-stroma interactions in carcinogenesis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Context-dependent activation of Wnt signaling by tumor suppressor RUNX3 in gastric cancer cells2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TNF-a/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inflammation-induced repression of tumor suppressor miR-7 in gastric tumor cells2012

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Cox-2 deletion in myeloid and endothelial cells, but not in epithelialcells2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prostaglandin E_2 signaling and bacterial infection recruit tumor-promoting macrophages to mouse gastric tumors2011

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Activation of epidermal growth factor receptor signaling by the prostaglandin E_2 receptor EP4 pathway during gastric tumorigenesis2011

Author(s)

ISHIKAWA Tomoo 石川智夫