NAKAHIGASHI Kenji 中東憲治

Researcher Number	70322740
Other IDs
Affiliation (based on the past Project Information) *help	2015: 慶應義塾大学, 先端生命研, 准教授 2014: 慶應義塾大学, 政策・メディア研究科, 特任准教授 2013 – 2014: 慶應義塾大学, その他の研究科, 准教授 2013: 慶應義塾大学, 政策･メディア研究科, 特任准教授 2012: 慶應義塾大学, 政策・メディア研究科, 特任准教授 … More 2009 – 2010: Keio University, 政策・メディア研究科, 准教授 2008: Keio University, 大学院・政策・メディア研究科, 准教授 2000: Dept.of Biophys., Gard.Sch.Sci.Kyoto Univ.(Assistant Professor), 大学院・理学研究科, 助手 Less
Review Section/Research Field	Principal Investigator System genome science / 基礎ゲノム科学 Except Principal Investigator Molecular biology / System genome science / Bioinformatics/Life informatics
Keywords	Principal Investigator 翻訳 / 抗生物質 / コドン / 翻訳制御 / リボソーム / ゲノム解析技術 / リボソームプロファイリング / マルチオミクス / 分子遺伝学 / タンパク質代謝 … More / 大腸菌 / プロテオミクス / 翻訳郊率 / タンパク質分解 / タンパク質ターンオーバー / ゲノム発現 … More Except Principal Investigator 大腸菌 / protoporphyrinogen IX oxidase / ferrochelatase / spinach (Spinacia oleracea) / thymidylate synthase / cucumber (Cucumis sativus) / hemF gene of E.coli / soybean (Glycine max) / rice (Oryza sativa) / ダイズ / キューリ / シロイヌナズナ / CPOX / PPOX / ポルフィリン / プロトポルフィリノゲンIXオキシダーゼ / フェロキレテース / ホウレンソウ(Spinacia oleracea) / チミジル酸合成酵素遺伝子 / キューリ(Cucumis sativus) / 大腸菌(E.coli)のhemF遺伝子 / ダイズ(Glycine max) / イネ(Orgza sativa) / 細胞内ネットワーク / 遺伝的ネットワーク / 二重欠失株 / Chemical Genomics / Multiplex解析 / population変動 / 貞コピー可動型発現プラスミド / deep sequence / 一遺伝子欠失株 / 分子バーコード / ケミカルバイオロジー / 長期定常期 / 大腸菌population変動解析 / バーコード解析 / deep sequencing / stationary phase / chemical genomics / population dynamics / deletion collection / bar-code / E. coli / 無細胞タンパク質合成系 / 酵素反応速度論 / 酵素 Less

Strategy of a cell to survive during a long term stationary phase before cell proliferation.
- Principal Investigator
  
  Mori Hirotada
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  System genome science
- Research Institution
  Nara Institute of Science and Technology
Genome wide analysis of translation efficiency by local structure of mRNA and nascent peptidePrincipal Investigator
- Principal Investigator
  
  NAKAHIGASHI Kenji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  System genome science
- Research Institution
  Keio University
Comprehensive analysis of protein turnoverPrincipal Investigator
- Principal Investigator
  
  NAKAHIGASHI Kenji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  基礎ゲノム科学
- Research Institution
  Keio University
人工代謝系を用いたキネティクソーム解析技術の開発と大腸菌中心炭素代謝系への応用
- Principal Investigator
  
  石井伸佳
- Project Period (FY)
  2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioinformatics/Life informatics
- Research Institution
  Keio University
Analysis of the genes for porphyrin biosynthetic pathway in higher plants utilizing the light-sensitive mutants of Escherichia coli
- Principal Investigator
  
  INOKUCHI Hachiro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Molecular biology
- Research Institution
  KYOTO UNIVERSITY

All 2016 2015 2014 2013 2012 2010 2009 2008 Other

All Journal Article Presentation Book

[Book] In Systems biology and biotechnology of Escherichia coli.(Yup LS ed)(Resources for Escherichia coli Systems Biology)2009
- Author(s)
  Mori H, Yamamoto N, Dose H, Nakahigashi K, Datsenko KA, Wanner BL
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-20310117
[Book] 遺伝子医学MOOK(マルチオミクス(multi-omics)解析で見えてきた大腸菌の遺伝・環境変化に対する応答機構, 16)
- Author(s)
  中東憲治、冨田勝
- Publisher
  株式会社メディカルドウ
- Data Source
  KAKENHI-PROJECT-20310117
[Journal Article] Comprehensive identification of translation start sites by Tetracycline-inhibited Ribosome Profiling (TetRP)2016
- Author(s)
  Kenji Nakahigashi Yuki Takai Michiko Kimura Nozomi Abe Toru Nakayashiki Yuh Shiwa Hirofumi Yoshikawa Barry L. Wanner Yasushi Ishihama Hirotada Mori
- Journal Title
  
  DNA Res
  
  Volume: Mar 23 Issue: 3 Pages: 1-8
- DOI
  10.1093/dnares/dsw008
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25250028
[Journal Article] GenoBase: comprehensive resource database of Escherichia coli K-122015
- Author(s)
  Otsuka Y, Muto A, Takeuchi R, Okada C, Ishikawa M, Nakamura K, Yamamoto N, Dose H, Nakahigashi K, Tanishima S, Suharnan S, Nomura W, Nakayashiki T, Aref WG, Bochner BR, Conway T, Gribskov M, Kihara D, Rudd KE, Tohsato Y, Wanner BL & Mori H
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 43 Issue: D1 Pages: 606-617
- DOI
  10.1093/nar/gku1164
- NAID
  120005830851
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24310148, KAKENHI-PUBLICLY-25108716
[Journal Article] Effect of codon adaptation on codon-level and gene-level translation efficiency in vivo2014
- Author(s)
  Nakahigashi K, Takai Y, Shiwa Y, Wada M, Honma M, Yoshikawa H, Tomita M, Kanai A, and Mori H
- Journal Title
  
  BMC Genomics
  
  Volume: 15 Issue: 1 Pages: 1115-1115
- DOI
  10.1186/1471-2164-15-1115
- NAID
  120005830843
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24310148, KAKENHI-PROJECT-25250028
[Journal Article] A systematic survey of in vivo obligate chaperonin-dependent substrates.2010
- Author(s)
  Fujiwara K, Ishihama Y, Nakahigashi K, Soga T, Taguchi H
- Journal Title
  
  EMBO J 29(9)
  
  Pages: 1552-1564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310117
[Journal Article] 13C-metabolic flux analysis for batch culture of Escherichia coli and its Pyk and Pgi gene knockout mutants based on mass isotopomer distribution of intracellular metabolites2010
- Author(s)
  Toya Y, Ishii N, Nakahigashi K, Hirasawa T, Soga T, Tomita M, Shimizu K
- Journal Title
  
  Biotechnol Prog 26(4)
  
  Pages: 975-992
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310117
[Journal Article] Systematic phenome analysis of Escherichia coli multiple-knockout mutants reveals hidden reactions in central carbon metabolism2009
- Author(s)
  中東憲治
- Journal Title
  
  Molecular Systems Biology 5
  
  Pages: 306-306
- NAID
  120005830850
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310117
[Journal Article] Update on the Keio collection of Escherichia coli single-gene deletion mutants2009
- Author(s)
  Yamamoto N, Nakahigashi K, Nakamichi T, Yoshino M, Takai Y, Touda Y, Furubayashi A, Kinjyo S, Dose H, Hasegawa M, Datsenko KA, Nakayashiki T, Tomita M, Wanner BL, Mori H
- Journal Title
  
  Mol Syst Biol 5
  
  Pages: 335-335
- NAID
  120005830849
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310117
[Journal Article] Systematic phenome analysis of Escherichia coli multiple-knockout mutants reveals hidden reactions in central carbon metabolism2009
- Author(s)
  Nakahigashi K, Toya Y, Ishii N, Soga T, Hasegawa M, Watanabe H, Takai Y, Honma M, Mori H, Tomita M
- Journal Title
  
  Mol Syst Biol 5
  
  Pages: 306-306
- NAID
  120005830850
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310117
[Journal Article] マルチオミクス解析で見えてきた大腸菌の遺伝・環境変化に対する応答機構2009
- Author(s)
  中東憲治
- Journal Title
  
  遺伝子医学MOOK 16
  
  Pages: 152-158
- Data Source
  KAKENHI-PROJECT-20310117
[Presentation] 遺伝子レベル、コドンレベルでの翻訳効率解析2014
- Author(s)
  中東憲治、高井幸、志波優、兼崎友、吉川博文、森浩禎、冨田勝
- Organizer
  第８回ゲノム微生物学会年会
- Place of Presentation
  東京都世田谷区
- Data Source
  KAKENHI-PROJECT-24310148
[Presentation] Deep Sequence Analysis of the relationship between sRNA- related factors and Dynamic Changes of sRNA Expression in Escherichia coli2013
- Author(s)
  Motomu Matsui, Yoshiki Ikeda, Gakuto Makino, Masaru Tomita, Akio Kanai, Kenji Nakahigashi
- Organizer
  JSBi2013
- Place of Presentation
  東京都江戸川区
- Data Source
  KAKENHI-PROJECT-24310148
[Presentation] Ribosome profilingによる翻訳開始部位の精密マッピング2013
- Author(s)
  中東憲治
- Organizer
  第7回日本ゲノム微生物学会年会
- Place of Presentation
  長浜バイオ大学
- Year and Date
  2013-03-10
- Data Source
  KAKENHI-PROJECT-24310148
[Presentation] Precise mapping of Translational initiation sites by Ribosome profiling2013
- Author(s)
  Kenji Nakahigashi
- Organizer
  UK-Japan Systems Microbiology Workshop
- Place of Presentation
  京都府京都市
- Invited
- Data Source
  KAKENHI-PROJECT-24310148
[Presentation] Ribosome profilingと抗生物質の特性を利用した大腸菌翻訳開始部位の再アノテーション2012
- Author(s)
  中東憲治
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡
- Year and Date
  2012-12-11
- Data Source
  KAKENHI-PROJECT-24310148
[Presentation] Comprehensive analysis of protein turnover (and its effect on metabolic simulation).2010
- Author(s)
  Kenji Nakahigashi
- Organizer
  UK-Japan Symposium of Systems and Synthetic Biology
- Place of Presentation
  Guildford UK
- Year and Date
  2010-09-14
- Data Source
  KAKENHI-PROJECT-20310117
[Presentation] Comprehensive analysis of protein turnover2010
- Author(s)
  Nakahigashi, K
- Organizer
  UK-Japan Systems & Synthetic Biology workshop
- Place of Presentation
  Surrey大学(英国)(招待講演)
- Year and Date
  2010-09-14
- Data Source
  KAKENHI-PROJECT-20310117
[Presentation] 増殖、非増殖状態におけるタンパク質ターンオーバーの環境変化に伴う変化2010
- Author(s)
  中東憲治
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-20310117
[Presentation] Degradation and turnover of protein in growing and non-growing E. coli cell after environmental perturbation.2010
- Author(s)
  Kenji Nakahigashi, Yasushi Ishihama, Toya Yoshihiro, Masaru Tomita
- Organizer
  BMB2010
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-20310117
[Presentation] Comprehensive analysis of protein turnover in aerobic and an aerobic continuous culture of E.coli2009
- Author(s)
  中東憲治
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-20310117
[Presentation] Systematic phenome analysis of Escherichia coli multiple-knockout mutants reveals hidden reactions in central carbon metabolism2009
- Author(s)
  中東憲治
- Organizer
  UK-Japan Workshop on Systems Biology
- Place of Presentation
  コスモスクエア国際交流センター大阪
- Year and Date
  2009-09-23
- Data Source
  KAKENHI-PROJECT-20310117
[Presentation] Systematic phenome analysis of E. coli multiple-knockout mutants reveals hidden reactions in central carbon metabolism2009
- Author(s)
  Kenji Nakahigashi
- Organizer
  UK-Japan Symposium of Systems Biology
- Place of Presentation
  Osaka
- Year and Date
  2009-09-23
- Data Source
  KAKENHI-PROJECT-20310117
[Presentation] Comprehensive analysis of protein turnover in aerobic and anaerobic continuous culture of E. coli2009
- Author(s)
  中東憲治, 石濱泰, 本間雅之, 高井幸, 冨田勝
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-20310117
[Presentation] Protein turnover-omics : Comprehensive analysis of protein turnover in E. coli.2008
- Author(s)
  Kenji Nakahigashi
- Organizer
  International E. coli Alliance for Systerns Biology
- Place of Presentation
  イギリス・ケンブリッジ
- Year and Date
  2008-09-25
- Data Source
  KAKENHI-PROJECT-20310117
[Presentation] Robustness of bacterial metabolic network. Views from Multi-Omics analysis.2008
- Author(s)
  Kenji Nakahigashi
- Organizer
  Design and Engineering of Microbial Genomes
- Place of Presentation
  中央研究院, 台北, 台湾
- Year and Date
  2008-11-26
- Data Source
  KAKENHI-PROJECT-20310117
[Presentation] Multi-Omics解析からてくるバクテリア代謝の頑強性2008
- Author(s)
  中東憲治
- Organizer
  第18回玉川微生物資源ワークショップ
- Place of Presentation
  三島
- Year and Date
  2008-10-31
- Data Source
  KAKENHI-PROJECT-20310117
[Presentation] Robustness of bacterial metabolic network. Views from Multi-Omics analysis.2008
- Author(s)
  Kenji Nakahigashi
- Organizer
  Design and Engineering of Microbial Genomes Academia Sinica Workshop
- Place of Presentation
  Taipei, Taiwan
- Year and Date
  2008-11-26
- Data Source
  KAKENHI-PROJECT-20310117
[Presentation] Protein-turnoveromics ; global analyses of protein turnover in E. coli2008
- Author(s)
  Kenji Nakahigashi, Yasushi Ishihama, Nobuyuki Ishii, Masaru Tomita
- Organizer
  IECA2008
- Place of Presentation
  Hixton UK
- Year and Date
  2008-09-26
- Data Source
  KAKENHI-PROJECT-20310117
[Presentation] Robustness of bacterial metabolic network. Views from multi-omics analysis2008
- Author(s)
  Kenji Nakahigashi
- Organizer
  Seminar at Center for Mathematical Modeling, University of Chile
- Place of Presentation
  サンチアゴ, チリ国
- Year and Date
  2008-12-27
- Data Source
  KAKENHI-PROJECT-20310117
[Presentation] Hfqとデグラドソーム変異によるsRNAとmRNA翻訳への影響
- Author(s)
  松井求、池田幸樹、牧野岳都、志波優、兼崎友、吉川博文、冨田勝、金井昭夫、中東憲治
- Organizer
  第37回日本分子学会年会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24310148
[Presentation] 大腸菌の増殖停止・再開と RNA-seq 解析
- Author(s)
  牧泰史、大塚悠太、上田雅美、和田明、古池晶、吉田秀司、中東憲治、森浩禎
- Organizer
  第九回ゲノム微生物学会
- Place of Presentation
  神戸大学（神戸）
- Year and Date
  2015-03-06 – 2015-03-08
- Data Source
  KAKENHI-PROJECT-24310148

1. MORI Hirotada (90182203)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. ISHIHAMA YASUSHI (30439244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. KANAI Akio (60260329)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. YAMADA Mamoru (30174741)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MATSUNO Hiroshi (10181744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TAMURA Takeyuki (00437261)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TOHSATO Yukari (80346171)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MAKI Yasushi (60401733)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SAITO Natsumi (50287546)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KOSAKA Tomouki (70500453)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. INOKUCHI Hachiro (20028195)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 石井伸佳 (80383941)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 片岡正和 (90332676)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NAKAHIGASHI Kenji 中東 憲治

Research Projects

Research Products

Co-Researchers

Strategy of a cell to survive during a long term stationary phase before cell proliferation.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genome wide analysis of translation efficiency by local structure of mRNA and nascent peptidePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Comprehensive analysis of protein turnoverPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

人工代謝系を用いたキネティクソーム解析技術の開発と大腸菌中心炭素代謝系への応用

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the genes for porphyrin biosynthetic pathway in higher plants utilizing the light-sensitive mutants of Escherichia coli

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] In Systems biology and biotechnology of Escherichia coli.(Yup LS ed)(Resources for Escherichia coli Systems Biology)2009

Author(s)

Publisher

Data Source

[Book] 遺伝子医学MOOK(マルチオミクス(multi-omics)解析で見えてきた大腸菌の遺伝・環境変化に対する応答機構, 16)

Author(s)

Publisher

Data Source

[Journal Article] Comprehensive identification of translation start sites by Tetracycline-inhibited Ribosome Profiling (TetRP)2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GenoBase: comprehensive resource database of Escherichia coli K-122015

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Effect of codon adaptation on codon-level and gene-level translation efficiency in vivo2014

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] A systematic survey of in vivo obligate chaperonin-dependent substrates.2010

Author(s)

Journal Title

Data Source

[Journal Article] 13C-metabolic flux analysis for batch culture of Escherichia coli and its Pyk and Pgi gene knockout mutants based on mass isotopomer distribution of intracellular metabolites2010

Author(s)

Journal Title

Data Source

[Journal Article] Systematic phenome analysis of Escherichia coli multiple-knockout mutants reveals hidden reactions in central carbon metabolism2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Update on the Keio collection of Escherichia coli single-gene deletion mutants2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Systematic phenome analysis of Escherichia coli multiple-knockout mutants reveals hidden reactions in central carbon metabolism2009

Author(s)

Journal Title

NAKAHIGASHI Kenji 中東憲治