Hasebe Takashi 長谷部孝

… Alternative Names

HASEBE Takashi 長谷部孝

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Researcher Number	70329027
Other IDs
External Links
Affiliation (Current)	2025: 日本医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2025: 日本医科大学, 医学部, 教授 2013 – 2020: 日本医科大学, 医学部, 准教授 2011: 日本医科大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Morphology/Structure / Basic Section 44040:Morphology and anatomical structure-related Except Principal Investigator Morphology/Structure
Keywords	Principal Investigator 甲状腺ホルモン / 消化管 / 幹細胞 / 両生類 / 上皮幹細胞 / 空間遺伝子発現解析 / 無尾両生類の変態 / RNA-seq / 両生類の変態 / 小腸上皮幹細胞 … More / トランスクリプトーム解析 / トランスジェネシス / 組織幹細胞 / Notch / Cre-Loxシステム / Notchシグナル / Notchシグナル経路 / 変態 … More Except Principal Investigator 変態 / 幹細胞 / 小腸 / アフリカツメガエル / 甲状腺ホルモン / ニッチ / シグナル伝達経路 / 器官培養 / Wntシグナル伝達経路 / 培養 / Wntシグナル経路 / Ror2 / Wnt / 上皮脱分化 / 遺伝子機能解析 / トランスゲネシス / ステロイドホルモン / 歯伝子機能解析 / 性分化 / 両生類 / 性決定関連遺伝子 / 免疫染色 / 性決定 / 性染色体 / ツチガエル / 性転換 / トランスゲニックカエル / アンドロゲン受容体 / アンドロゲン / 組織構築 / 上皮再生 / 甲状腺ホルモン応答遺伝子 / 脱分化 / 組織間相互作用 / 甲状腺ホルモン受容体 / トランスジェニックカエル Less

小腸上皮幹細胞の追跡と空間遺伝子発現解析による幹細胞特異的遺伝子の探索と機能解析Principal Investigator
- Principal Investigator
  
  長谷部孝
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44040:Morphology and anatomical structure-related
- Research Institution
  Nippon Medical School
Identification of genes specific to the intestinal epithelial stem cells and their functional analysis by making use of transgenic frogsPrincipal Investigator
- Principal Investigator
  
  Hasebe Takashi
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphology/Structure
- Research Institution
  Nippon Medical School
Lineage analysis of intestinal stem cells and development of the culture system to study the stem cell niche
- Principal Investigator
  
  ISHIZUYA-OKA Atsuko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphology/Structure
- Research Institution
  Nippon Medical School
Origin of the adult epithelial stem cell in the Xenopus laevis intestine and the role of Notch signaling in the stem cell regulationPrincipal Investigator
- Principal Investigator
  
  Hasebe Takashi
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphology/Structure
- Research Institution
  Nippon Medical School
Molecular mechanisms of development of the stem cell niche regulating intestinal epithelial dedifferentiation
- Principal Investigator
  
  ISHIZUYA-OKA Atsuko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphology/Structure
- Research Institution
  Nippon Medical School
The study for the mechanism of steroid hormone-dependent sex determination in amphibians
- Principal Investigator
  
  NAKAMURA MASAHISA
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Morphology/Structure
- Research Institution
  Waseda University
Study of the intestinal epithelial stem cell niche using transgenic frogs
- Principal Investigator
  
  OKA Atsuko
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphology/Structure
- Research Institution
  Nippon Medical School

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation

[Journal Article] Stem cell development involves divergent thyroid hormone receptor subtype expression and epigenetic modifications in the Xenopus metamorphosing intestine2020
- Author(s)
  Hasebe Takashi、Fujimoto Kenta、Buchholz Daniel R.、Ishizuya-Oka Atsuko
- Journal Title
  
  General and Comparative Endocrinology
  
  Volume: 292 Pages: 113441-113441
- DOI
  10.1016/j.ygcen.2020.113441
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07475, KAKENHI-PROJECT-18K06320
[Journal Article] Thyroid hormone-induced expression of Foxl1 in subepithelial fibroblasts correlates with adult stem cell development during Xenopus intestinal remodeling2020
- Author(s)
  Hasebe Takashi、Fujimoto Kenta、Ishizuya-Oka Atsuko
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 20715-20715
- DOI
  10.1038/s41598-020-77817-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06320, KAKENHI-PROJECT-17K07475
[Journal Article] Expression of hyaluronan synthases upregulated by thyroid hormone is involved in intestinal stem cell development during Xenopus laevis metamorphosis2018
- Author(s)
  Fujimoto Kenta、Hasebe Takashi、Kajita Mitsuko、Ishizuya-Oka Atsuko
- Journal Title
  
  Development Genes and Evolution
  
  Volume: 228 Issue: 6 Pages: 267-273
- DOI
  10.1007/s00427-018-0623-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07475, KAKENHI-PROJECT-18K06320
[Journal Article] Thyroid hormone-induced activation of Notch signaling is required for adult intestinal stem cell development during Xenopus laevis metamorphosis2017
- Author(s)
  Hasebe T, Fujimoto K, Kajita M, Fu L, Shi Y-B, Ishizuya-Oka A
- Journal Title
  
  Stem Cells
  
  Volume: 35 Issue: 4 Pages: 1028-1039
- DOI
  10.1002/stem.2544
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440160, KAKENHI-PROJECT-15K07136
[Journal Article] Functional analysis of thyroid hormone receptor beta in Xenopus tropicalis founders using CRISPR-Cas2017
- Author(s)
  Sakane Y, Iida M, Hasebe T, Fujii S, Buchholz DR, Ishizuya-Oka A, Yamamoto T, Suzuki KT
- Journal Title
  
  Biology Open
  
  Volume: 7 Pages: 1-9
- DOI
  10.1242/bio.030338
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07475, KAKENHI-PROJECT-15J05833, KAKENHI-PROJECT-15K06802, KAKENHI-PROJECT-15K07136
[Journal Article] Essential roles of thyroid hormone-regulated hyaluronan/CD44 signaling in adult stem cell development during Xenopus laevis intestinal remodeling2017
- Author(s)
  Hasebe T, Fujimoto K, Kajita M, Ishizuya-Oka A
- Journal Title
  
  Stem Cells
  
  Volume: 35 Issue: 10 Pages: 2175-2183
- DOI
  10.1002/stem.2671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07475, KAKENHI-PROJECT-15K07136
[Journal Article] Thyroid hormone activates Wnt/beta-catenin signaling involved in adult epithelial development during intestinal remodeling in Xenopus laevis2016
- Author(s)
  Hasebe T, Fujimoto K, Kajita M, Ishizuya-Oka A
- Journal Title
  
  Cell Tissue Res
  
  Volume: 365 Issue: 2 Pages: 309-318
- DOI
  10.1007/s00441-016-2396-8
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25440160
[Journal Article] Thyroid hormone activates Wnt/beta-catenin signaling involved in adult epithelial development during Xenopus laevis intestinal remodeling2016
- Author(s)
  Hasebe, T., Fujimoto K., Kajita M., Ishizuya-Oka, A.
- Journal Title
  
  Cell & Tissue Research
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07136
[Journal Article] A requirement for hedgehog signaling in thyroid hormone-induced postembryonic intestinal remodeling.2015
- Author(s)
  Wen, L., Hasebe, T., Miller T.C., Ishizuya-Oka, A., Shi Y.-B.
- Journal Title
  
  Cell & Bioscience
  
  Volume: 5 Issue: 1 Pages: 1-12
- DOI
  10.1186/s13578-015-0004-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24570078, KAKENHI-PROJECT-25440160
[Journal Article] Involvement of androgen receptor in sex determination in an amphibian species2014
- Author(s)
  Fujii, J., Kodama, M., Oike, A., Matsuo, Y., Min, M.S., Hasebe, T., Ishizuya-Oka, A., Kawakami, K., and Nakamura, M.
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 5 Pages: e93655-e93655
- DOI
  10.1371/journal.pone.0093655
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23241063, KAKENHI-PROJECT-25440160
[Journal Article] Involvement of androgen receptor in sex determination in an aphibian species2014
- Author(s)
  Jun Fujii, Maho Kodama, Akira Oike, Yasuki Matsuo, Mi-Sook Min, Takashi Hasebe, Yasuki Matsuo, Atsuko Ishizuya-Oka, Koichi Kawakami, Masahisa Nakamura
- Journal Title
  
  Plos ONE
  
  Volume: (in press.)
- Data Source
  KAKENHI-PROJECT-22370027
[Journal Article] Thyroid hormone-regulated Wnt5a/Ror2 signaling is essential for dedifferentiation of larval epithelial cells into adult stem cells in the Xenopus laevis intestine.2014
- Author(s)
  Ishizuya-Oka, A., Kajita M., Hasebe, T.
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 9 Pages: e107611-e107611
- DOI
  10.1371/journal.pone.0107611
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24570078, KAKENHI-PROJECT-25440160
[Journal Article] Involvement of androgen receptor in sex determination in an aphibian species2014
- Author(s)
  Jun Fujii, Maho Kdama, Akira Oike, Yasuki Matsuo, Mi-Sook Min, Takashi Hasebe, Yasuki Matsuo, Atsuko Ishizuya-Oka, Koichi Kawakami, Masahisa Nakamura
- Journal Title
  
  Plos ONE
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370027
[Journal Article] Establishment of intestinal stem cell niche during amphibian metamorphosis2013
- Author(s)
  Ishizuya-Oka A, Hasebe T
- Journal Title
  
  Current Topics in Developmental Biology
  
  Volume: 103 Pages: 305-327
- DOI
  10.1016/b978-0-12-385979-2.00011-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570078
[Journal Article] Expression profiling of intestinal tissues implicates novel genes and pathways essential for adult stem cell development2013
- Author(s)
  Sun, G., Heimeier R. A., Fu, L., Hasebe, T., Das, B., Ishizuya-Oka, A., Shi, Y.-B.
- Journal Title
  
  Endocrinology
  
  Volume: 154 Issue: 11 Pages: 4396-4407
- DOI
  10.1210/en.2013-1432
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570078, KAKENHI-PROJECT-25440160
[Journal Article] Tissue-specific upregulation of MDS/EVI gene transcripts in the intestine by thyroid hormone during Xenopus metamorphosis2013
- Author(s)
  Miller TC, Sun G, Hasebe T, Fu L, Heimeier RA, Das B, Ishizuya-Oka A, Shi Y-B
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 1 Pages: e55585-e55585
- DOI
  10.1371/journal.pone.0055585
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570078, KAKENHI-PROJECT-25440160
[Journal Article] Thyroid hormone-induced cell-cell interactions in the development of adult intestinal stem cells2013
- Author(s)
  Hasebe, T., Liezhen Fu, L., Thomas C. Miller, T. C., Zhang, Y., Shi Y.-B., Ishizuya-Oka., A.
- Journal Title
  
  Cell & Bioscience
  
  Volume: 3 Issue: 1 Pages: 18-18
- DOI
  10.1186/2045-3701-3-18
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570078, KAKENHI-PROJECT-25440160
[Journal Article] Thyroid hormone-induced sonic hedge-hog signal up-regulates its own pathway in a paracrine manner in the Xenopus laevis intestine during metamorphosis2012
- Author(s)
  Hasebe T., Kajita M., Fu L., Shi Y.-B., Ishizuya-Oka A
- Journal Title
  
  Dev. Dyn
  
  Volume: 241 Issue: 2 Pages: 403-414
- DOI
  10.1002/dvdy.23723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570060
[Journal Article] 変態現象をモデルとした、小腸上皮幹細胞の発生2012
- Author(s)
  長谷部孝、岡敦子
- Journal Title
  
  日本医科大学医学会雑誌
  
  Volume: 8 Pages: 4-5
- NAID
  130004942020
- Data Source
  KAKENHI-PROJECT-20570060
[Journal Article] Spatiotemporal expression profile of NO29/nucleophosmin3 in the intestine of Xenopus laevis during metamorphosis2011
- Author(s)
  Motoi N., Hasebe T., Suzuki KT., Ishizuya-Oka A
- Journal Title
  
  Cell Tissue Res
  
  Volume: 344 Issue: 3 Pages: 445-453
- DOI
  10.1007/s00441-011-1163-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570060
[Journal Article] The development of the adult intestinal stem cells : Insights from studies on thyroid hormone-dependent amphibian metamorphosis2011
- Author(s)
  Shi Y.-B., Hasebe T., Fu L., Fujimoto K., Ishizuya-Oka A
- Journal Title
  
  Cell Biosci
  
  Volume: 1 Issue: 1 Pages: 30-30
- DOI
  10.1186/2045-3701-1-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570060
[Journal Article] Thyroid hormone-regulated expression of nuclear lamins correlates with dediffe-rentiation of intestinal epithelial cells during Xenopus laevis metamorphosis2011
- Author(s)
  Hasebe T., Kajita M., Iwabuchi M., Ohsumi K., Ishizuya-Oka A
- Journal Title
  
  Dev. Genes Evol
  
  Volume: 211 Issue: 4 Pages: 199-208
- DOI
  10.1007/s00427-011-0371-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570060, KAKENHI-PUBLICLY-23114705, KAKENHI-PROJECT-23370091
[Journal Article] RCAN1 regulates vascular branching during Xenopus laevis angiogenesis2011
- Author(s)
  Fujiwara M., Hasebe T., Kajita M., Ishizuya-Oka A., Ghazizadeh M., Kawanami O.
- Journal Title
  
  J.Vascular Res.
  
  Volume: 48 Pages: 104-118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570060
[Journal Article] Spatio-temporal expression profile of stem cell-associated gene LGR5 in the intestine during thyroid hormone-depen-dent metamorphosis in Xenopus laevis2010
- Author(s)
  Sun G., Hasebe T., Fujimoto K., Lu R., Fu L., Matsuda H., Kajita M, Ishizuya-Oka A., Shi Y.-B
- Journal Title
  
  PLoS ONE
  
  Volume: 5 Issue: 10 Pages: e13605-e13605
- DOI
  10.1371/journal.pone.0013605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570060
[Journal Article] Tissue-dependent induction of apoptosis by matrix metalloproteinase stromelysin-3 during amphibian metamorphosis.2010
- Author(s)
  Mathew S., Fu L., Hasebe T., Ishizuya-Oka A., Shi Y.-B.
- Journal Title
  
  Birth Defects Research(Part C) 90
  
  Pages: 55-66
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570060
[Journal Article] Epithelial-connective tissue interactions induced by thyroid hormone receptor are essential for adult stem cell development in the Xenopus laevis intestine2010
- Author(s)
  Hasebe T., Buchholz D. R., Shi Y.-B., Ishizuya-Oka, A
- Journal Title
  
  Stem Cells
  
  Volume: 29 Issue: 1 Pages: 154-161
- DOI
  10.1002/stem.560
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570060
[Journal Article] Spatio-temporal expression profile of stem cell-associated gene LGR5 in the intestine during thyroid hormone-dependent metamorphosis in Xenopus laevis2010
- Author(s)
  Sun G., Hasebe T., Fujimoto K., Lu R., Fu L., Matsuda H., Kajita M., Ishizuya-Oka A., Shi Y.-B.
- Journal Title
  
  PLoS ONE
  
  Volume: 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570060
[Journal Article] Tissue-dependent induction of apoptosis by matrix metalloproteinase stromely-sin-3 during amphibian metamorphosis. Birth Defects Res2010
- Author(s)
  Mathew S., Fu, L., Hasebe T., Ishizuya-Oka A., Shi Y.-B
- Journal Title
  
  PartC
  
  Volume: 90 Issue: 1 Pages: 55-66
- DOI
  10.1002/bdrc.20170
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570060
[Journal Article] Epithelial-connective tissue interactions induced by thyroid hormone receptor are essential for adult stem cell development in the Xenopus Iaevis intestine.2010
- Author(s)
  Hasebe T., Buchholz D.R., Shi Y.-B., Ishizuya-Oka, A.
- Journal Title
  
  Stem Cells 29
  
  Pages: 154-161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570060
[Journal Article] Apoptosis in amphibian organs during metamorphosis2010
- Author(s)
  Ishizuya-Oka A., Hasebe T., Shi Y.-B.
- Journal Title
  
  Apoptosis 15
  
  Pages: 350-364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570060
[Journal Article] アフリカツメガエル初期胚を用いた遺伝子の機能解析2009
- Author(s)
  長谷部孝, 藤原正和, 川並汪一, 岡敦子
- Journal Title
  
  日本医科大学医学会雑誌 5
  
  Pages: 4-5
- NAID
  130004471402
- Data Source
  KAKENHI-PROJECT-20570060
[Journal Article] The origin of the adult intestinal stem cells induced by thyroid hormone in Xenopus laevis2009
- Author(s)
  Ishizuya-Oka A., Hasebe T., Buchholz D. R., Kajita M., Fu L., Shi Y.-B
- Journal Title
  
  FASEB J
  
  Volume: 23(8) Issue: 8 Pages: 2568-2575
- DOI
  10.1096/fj.08-128124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570060
[Journal Article] The origin of the adult intestinal stem cells induced by thyroid hormone in Xenopus Iaevis.2009
- Author(s)
  Ishizuya-Oka A., Hasebe T., Buchholz D.R., Kajita M., Fu L., Shi Y.-B.
- Journal Title
  
  FASEB J. 23(8)
  
  Pages: 2568-2575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570060
[Journal Article] The Origin of the adult intestinal stem cells induced by thyroid hormone in Xenopus laevis2009
- Author(s)
  Ishizuya-Oka A., Hasebe T., Buchholz D.R., Kajita M., Fu L., Shi Y-B
- Journal Title
  
  FASEB Journal 23
  
  Pages: 2568-2575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570060
[Journal Article] Thyroid hormone-upregulated hedgehog interacting protein is involved in larval-to-adult intestinal remodeling by regulating sonic hedgehog signaling pathway in Xenopus laevis2008
- Author(s)
  Hasebe T., Kajita M., Shi Y.-B., Ishizuya-Oka A
- Journal Title
  
  Dev. Dyn
  
  Volume: 237 Issue: 10 Pages: 3006-3015
- DOI
  10.1002/dvdy.21698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570060
[Journal Article] Thyroid hormone-upregulated hedgehog interacting protein is involved in larval-to-adult intestinal remodeling by regulating sonic hedgehog signaling pathway in Xenopus laevis2008
- Author(s)
  Hasebe, T., Kajita, M., Shi, Y. -B., Ishizuya-Oka, A.
- Journal Title
  
  Developmental Dynamics 237
  
  Pages: 3006-3015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570060
[Journal Article] Thyroid hormone-upregulated hedgehog interacting protein is involved in larval-to-adult intestinal remodeling by regulating sonic hedgehog signaling pathway in Xenopus Iaevis.2008
- Author(s)
  Hasebe T., Kajita M., Shi Y.-B., Ishizuya-Oka A.
- Journal Title
  
  Dev.Dyn.(有) 237
  
  Pages: 3006-3015
- Data Source
  KAKENHI-PROJECT-20570060
[Presentation] アフリカツメガエルの消化管再構築におけるHippo経路の役割2020
- Author(s)
  長谷部孝、藤本健太、岡敦子
- Organizer
  第91回日本動物学会大会
- Data Source
  KAKENHI-PROJECT-17K07475
[Presentation] アフリカツメガエル小腸の成体幹細胞の発生に関わるWnt遺伝子群の発現解析2020
- Author(s)
  藤本健太、長谷部孝、岡敦子
- Organizer
  第91回日本動物学会大会
- Data Source
  KAKENHI-PROJECT-17K07475
[Presentation] アフリカツメガエル変態期の消化管再構築における甲状腺ホルモン受容体サブタイプの発現とエピジェネティックな変化2019
- Author(s)
  長谷部孝、藤本健太、Daniel R. Buchholz、岡敦子
- Organizer
  第44回日本比較内分泌学会大会およびシンポジウム
- Data Source
  KAKENHI-PROJECT-17K07475
[Presentation] アフリカツメガエルの消化管再構築におけるHippo関連遺伝子のホメオログ特異的な発現変動2019
- Author(s)
  長谷部孝、藤本健太、岡敦子
- Organizer
  日本動物学会第90回大会
- Data Source
  KAKENHI-PROJECT-17K07475
[Presentation] Possible roles of hyaluronan signaling in stem cell niche formation during intestinal remodeling in Xenopus laevis2018
- Author(s)
  Fujimoto K, Hasebe T, Kajita M, Ishizuya-Oka A
- Organizer
  第70回日本細胞生物学会　第51回日本発生生物学会　合同大会
- Data Source
  KAKENHI-PROJECT-17K07475
[Presentation] アフリカツメガエル小腸におけるヒアルロン酸シグナルの幹細胞ニッチ形成に果たす役割2018
- Author(s)
  藤本健太、長谷部孝、梶田満子、岡敦子
- Organizer
  第123回日本解剖学会
- Data Source
  KAKENHI-PROJECT-15K07136
[Presentation] アフリカツメガエル小腸におけるヒアルロン酸シグナルの幹細胞ニッチ形成に果たす役割2018
- Author(s)
  藤本健太、長谷部孝、梶田満子、岡敦子
- Organizer
  日本解剖学会総会・全国学術集会（第１２３回）
- Data Source
  KAKENHI-PROJECT-17K07475
[Presentation] アフリカツメガエル変態期の消化管再構築におけるHippo関連遺伝子の発現解析2018
- Author(s)
  長谷部孝、藤本健太、岡敦子
- Organizer
  第89回日本動物学会札幌大会
- Data Source
  KAKENHI-PROJECT-17K07475
[Presentation] アフリカツメガエルの小腸再構築におけるヒアルロン酸シグナルの役割2017
- Author(s)
  藤本健太、長谷部孝、梶田満子、岡敦子
- Organizer
  第50回日本発生生物会大会
- Data Source
  KAKENHI-PROJECT-15K07136
[Presentation] アフリカツメガエル小腸上皮の幹細胞制御におけるヒアルロン酸/CD44シグナルの役割2017
- Author(s)
  長谷部孝、藤本健太、梶田満子、岡敦子
- Organizer
  日本動物学会第88回大会
- Data Source
  KAKENHI-PROJECT-17K07475
[Presentation] アフリカツメガエル消化管再構築の分子基盤：Notch シグナルの役割2017
- Author(s)
  長谷部孝、岡敦子
- Organizer
  日本動物学会第88回大会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17K07475
[Presentation] Implicated role of hyaluronan signaling in adult epithelial development during intestinal remodeling in Xenopus leavis2017
- Author(s)
  Fujimoto K, Hasebe T, Kajita M, Ishizuya-Oka A
- Organizer
  Annual Meeting of the Japanese Society of Developmental Biologists (50th)
- Data Source
  KAKENHI-PROJECT-17K07475
[Presentation] 無尾両生類の変態における幽門形成の組織学と遺伝子発現2017
- Author(s)
  名倉京、佐藤夢子、長谷部孝、岡敦子、平良眞規
- Organizer
  第40回日本分子生物会大会
- Data Source
  KAKENHI-PROJECT-15K07136
[Presentation] アフリカツメガエル小腸上皮の幹細胞制御におけるヒアルロン酸/CD44シグナルの役割2017
- Author(s)
  長谷部孝、藤本健太、梶田満子、岡敦子
- Organizer
  第88回日本動物学会
- Data Source
  KAKENHI-PROJECT-15K07136
[Presentation] アフリカツメガエル消化管再構築の分子基盤：Notch シグナルの役割2017
- Author(s)
  長谷部孝、岡敦子
- Organizer
  第88回日本動物学会シンポジウム「両生類はワンダーランド」
- Invited
- Data Source
  KAKENHI-PROJECT-15K07136
[Presentation] アフリカツメガエルの消化管再構築におけるヒアルロン酸合成酵素の遺伝子発現解析2016
- Author(s)
  藤本健太、長谷部孝、梶田満子、岡敦子
- Organizer
  日本分子生物学会年会（第39回）
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25440160
[Presentation] アフリカツメガエルの消化管再構築においてWntシグナルは甲状腺ホルモンにより活性化され成体型上皮の発生に関与する2016
- Author(s)
  長谷部孝、藤本健太、岡敦子
- Organizer
  第57回日本組織細胞化学会学術集会
- Place of Presentation
  杏林大学井の頭キャンパス（東京・三鷹）
- Year and Date
  2016-09-03
- Data Source
  KAKENHI-PROJECT-15K07136
[Presentation] アフリカツメガエルの消化管再構築においてWntシグナルは甲状腺ホルモンにより活性化され成体型上皮の発生に関与する2016
- Author(s)
  長谷部孝、藤本健太、岡敦子
- Organizer
  日本組織細胞化学会総会・学術集会（第57回)
- Place of Presentation
  東京
- Year and Date
  2016-09-03
- Data Source
  KAKENHI-PROJECT-25440160
[Presentation] アフリカツメガエルの消化管再構築におけるヒアルロン酸合成酵素の遺伝子発現解析2016
- Author(s)
  藤本健太、長谷部孝、梶田満子、岡敦子
- Organizer
  第39回日本分子生物会大会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-15K07136
[Presentation] Thyroid hormone-induced activation of Notch signaling is required for intestinal remodeling during Xenopus laevis metamorphosis2016
- Author(s)
  Hasebe T, Fujimoto K, Kajita M, Fu L, Shi Y-B, Ishizuya-Oka A
- Organizer
  The joint meeting of the 22nd International Congress of Zoology and the 87th Meeting of the Zoological Society of Japan
- Place of Presentation
  沖縄
- Year and Date
  2016-11-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440160
[Presentation] Thyroid hormone-induced activation of Notch signaling is required for intestinal remodeling during Xenopus laevis metamorphosis2016
- Author(s)
  長谷部孝、藤本健太、梶田満子、Fu L.、Shi Y.-B.、岡敦子
- Organizer
  第87回日本動物学会大会
- Place of Presentation
  沖縄コンベンションセンター（沖縄・宜野湾）
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-15K07136
[Presentation] ツメガエル変態期の消化管再構築におけるNotchシグナルの役割：DLL1とDLL2の発現解析2015
- Author(s)
  長谷部孝、梶田満子、岡敦子
- Organizer
  第86回日本動物学会大会
- Place of Presentation
  朱鷺メッセ：新潟コンベンションセンター（新潟）
- Year and Date
  2015-09-19
- Data Source
  KAKENHI-PROJECT-15K07136
[Presentation] ツメガエル変態期の消化管再構築におけるNotchシグナルの役割：DLL1とDLL2の発現解析2015
- Author(s)
  長谷部孝、梶田満子、岡敦子
- Organizer
  日本動物学会第86回大会
- Place of Presentation
  新潟
- Year and Date
  2015-09-19
- Data Source
  KAKENHI-PROJECT-25440160
[Presentation] アフリカツメガエル変態期の消化管再構築におけるJagged 1とJagged 2の発現解析2014
- Author(s)
  関本篤人、福永悦也、梶田満子、長谷部孝、岡敦子
- Organizer
  第85回日本動物学会大会
- Place of Presentation
  東北大学（仙台）
- Year and Date
  2014-09-13
- Data Source
  KAKENHI-PROJECT-24570078
[Presentation] アフリカツメガエル変態期の消化管再構築における JaggedとJagged 2 の発現解析2014
- Author(s)
  関本篤人、福永悦也、梶田満子、長谷部孝、岡敦子
- Organizer
  日本動物学会第85回大会
- Place of Presentation
  仙台
- Year and Date
  2014-09-13
- Data Source
  KAKENHI-PROJECT-25440160
[Presentation] Notch signaling-dependent gene expression of Hairy1 and Hairy2b during adult stencil development in the Xenopus laevis intestine2014
- Author(s)
  Hasebe, T., Kajita, M., Ishizuya-Oka, A.
- Organizer
  The 8th International Symposium on Amphibian and Reptilian Endocrinology and Neurobiology
- Place of Presentation
  岡崎
- Year and Date
  2014-11-07
- Invited
- Data Source
  KAKENHI-PROJECT-25440160
[Presentation] アフリカツメガエル小腸上皮の脱分化機構: Wnt5a/Ror2シグナルの関与2013
- Author(s)
  岡敦子、長谷部孝
- Organizer
  日本動物学会第84回大会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-25440160
[Presentation] アフリカツメガエル変態期の小腸におけるHairy1とHairy2bの発現はNotchシグナル依存的である2013
- Author(s)
  長谷部孝、梶田満子、岡敦子
- Organizer
  日本動物学会第84回大会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-25440160
[Presentation] アンドロゲンとその受容体はツチガエルの性を決める?2013
- Author(s)
  児玉万穂、藤井淳、松尾安希、長谷部孝、岡敦子、中村正久
- Organizer
  日本動物学会第84回大会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-25440160
[Presentation] アフリカツメガェル変態期の消化管再構築における転写因子Gli1-3の発現解析2011
- Author(s)
  長谷部孝、梶田満子、岡敦子
- Organizer
  第82回日本動物学会大会
- Place of Presentation
  大雪クリスタルホール(旭川)
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-20570060
[Presentation] アフリカツメガエル変態期の消化管再構築における転写因子Gli1-3の発現解析2011
- Author(s)
  長谷部孝、梶田満子、岡敦子
- Organizer
  第82回日本動物学会大会
- Place of Presentation
  旭川大雪クリスタルホール
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-20570060
[Presentation] ドミナントポジティブ型甲状腺ホルモン受容体の発現により誘起されるアフリカツメガエル成体型腸上皮の発生2010
- Author(s)
  長谷部孝、岡敦子
- Organizer
  第43回日本発生学会大会
- Place of Presentation
  京都国際会館
- Year and Date
  2010-06-22
- Data Source
  KAKENHI-PROJECT-20570060
[Presentation] ドミナントポジティブ型甲状腺ホルモン受容体の発現により誘起されるアフリカツメガエル成体型腸上皮の発生2010
- Author(s)
  長谷部孝、岡敦子
- Organizer
  第43回日本発生学会大会
- Place of Presentation
  京都国際会館(京都)
- Year and Date
  2010-06-22
- Data Source
  KAKENHI-PROJECT-20570060
[Presentation] アフリカツメガエル変態期の消化管におけるSmoothenedの発現解析2010
- Author(s)
  長谷部孝、梶田満子、岡敦子
- Organizer
  第81回日本動物学会大会
- Place of Presentation
  東京大学駒場キャンパス(東京都)
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-20570060
[Presentation] アフリカツメガエル変態期の消化管におけるSmoothenedの発現解析2010
- Author(s)
  長谷部孝、梶田満子、岡敦子
- Organizer
  第81回日本動物学会大会
- Place of Presentation
  東京大学駒場
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-20570060
[Presentation] 両生類の消化管再構築においてShhシグナルに応答して促進されるPatched-1の発現解析2009
- Author(s)
  長谷部孝、梶田満子、岡敦子
- Organizer
  第80回日本動物学会大会
- Place of Presentation
  静岡グランシップ
- Year and Date
  2009-09-17
- Data Source
  KAKENHI-PROJECT-20570060
[Presentation] Hedgehog interacting protein regulates Sonic hedgehog signaling essential for the intestinal remodeling during amphibian metamorphosis2009
- Author(s)
  Hasebe T., Kajita M., Ishizuya-Oka A
- Organizer
  6th International Symposium on Amphibian and Reptilian Endocrinology & Neurobiology Berlin
- Place of Presentation
  Germany
- Year and Date
  2009-09-23
- Data Source
  KAKENHI-PROJECT-20570060
[Presentation] Hedgehog interacting protein regulates sonic hedgehog signaling essential for the intestinal remodeling during amphibian metamorphosis2009
- Author(s)
  Hasebe T., Kajita M., Ishizuya-Oka A.
- Organizer
  6th International Symposium on Amphibian and Reptilian Endocrinology and Neurobiology
- Place of Presentation
  Berlin, Germany
- Year and Date
  2009-09-23
- Data Source
  KAKENHI-PROJECT-20570060
[Presentation] トランスジェニックカエルは光り輝く2009
- Author(s)
  長谷部孝、岡敦子
- Organizer
  第80回日本動物学会大会
- Place of Presentation
  グランシップ(静岡県)
- Year and Date
  2009-09-17
- Data Source
  KAKENHI-PROJECT-20570060
[Presentation] Hedgehog interacting protein regulates Sonic hedgehog signaling essential for the intestinal remodeling during amphibian metamorphosis.2009
- Author(s)
  Hasebe T., Kajita M., Ishizuya-Oka A.
- Organizer
  6th International Symposium on Amphibian and Reptilian Endocrinology & Neurobiology
- Place of Presentation
  Berlin, Germany
- Year and Date
  2009-09-23
- Data Source
  KAKENHI-PROJECT-20570060
[Presentation] 両生類の消化管再構築においてshhシグナルに応答して促進されるPatched-1の発現解析2009
- Author(s)
  長谷部孝、梶田満子、岡敦子
- Organizer
  第80回日本動物学会大会
- Place of Presentation
  グランシップ(静岡県)
- Year and Date
  2009-09-17
- Data Source
  KAKENHI-PROJECT-20570060
[Presentation] 小腸再構築におけるSonic hedgehogシグナル伝達経路に関わる遺伝子の発現解析2009
- Author(s)
  長谷部孝, 梶田満子, 岡敦子
- Organizer
  第5回日本消化管学会学術集会
- Place of Presentation
  東京
- Year and Date
  2009-02-13
- Data Source
  KAKENHI-PROJECT-20570060
[Presentation] アフリカツメガエルの成体型小腸上皮を形成する幹細胞の起源2008
- Author(s)
  岡敦子, 梶田満子, 長谷部孝
- Organizer
  日本動物学会第79回大会
- Place of Presentation
  福岡
- Year and Date
  2008-09-07
- Data Source
  KAKENHI-PROJECT-20570060
[Presentation] アフリカツメガエルの成体型小腸上皮を形成する幹細胞の起源2008
- Author(s)
  岡敦子、梶田満子、長谷部孝
- Organizer
  第79回日本動物学会大会
- Place of Presentation
  福岡大学七隈
- Year and Date
  2008-09-07
- Data Source
  KAKENHI-PROJECT-20570060
[Presentation] Expression profile of hedgehog interacting protein suggests its involvement in the intestinal remodeling during Xenopus laevis metamorphosis2008
- Author(s)
  Hasebe, T., Kajita, M., Ishizuya-Oka, A.
- Organizer
  日本発生学会第41回大会
- Place of Presentation
  徳島
- Year and Date
  2008-05-28
- Data Source
  KAKENHI-PROJECT-20570060
[Presentation] アフリカツメガエル変態期の消化管再構築におけるhairy-1およびhairy-2bの発現解析
- Author(s)
  長谷部孝、梶田満子、岡敦子
- Organizer
  第83回日本動物学会大会
- Place of Presentation
  大阪大学（大阪）
- Data Source
  KAKENHI-PROJECT-24570078
[Presentation] アンドロゲンとその受容体はツチガエルの性を決める？
- Author(s)
  児玉　万穂、藤井　淳、松尾　安希、長谷部孝、岡敦子、中村　正久
- Organizer
  第84回日本動物学会大会
- Place of Presentation
  岡山大学（岡山）
- Data Source
  KAKENHI-PROJECT-24570078
[Presentation] アフリカツメガエル変態期の小腸におけるHairy-1とHairy-2bの発現はNotchシグナル依存的である
- Author(s)
  長谷部孝、岡敦子
- Organizer
  第84回日本動物学会大会
- Place of Presentation
  岡山大学（岡山）
- Data Source
  KAKENHI-PROJECT-24570078
[Presentation] Notch signaling-dependent gene expression of Hairy1 and Hairy2b during adult stem cell development in the Xenopus laevis intestine
- Author(s)
  Hasebe, T., Kajita, M., Ishizuya-Oka, A.
- Organizer
  The 8th biennial conference of the ISAREN
- Place of Presentation
  基礎生物学研究所（岡崎）
- Year and Date
  2014-11-07 – 2014-11-09
- Data Source
  KAKENHI-PROJECT-24570078
[Presentation] Involvement of androgen and its receptor in male sex determination in Rana rugosa frogs
- Author(s)
  M.Nakamura,J.Fujii,M.Kodama,T.Hasebe,A.Oka,Y.Nakamura,
- Organizer
  The Society for the Study of Reproduction
- Place of Presentation
  Montreal, Canada
- Data Source
  KAKENHI-PROJECT-22370027
[Presentation] アフリカツメガエル小腸上皮の脱分化機構：Wnt5a/Ror2シグナルの関与
- Author(s)
  岡敦子、長谷部孝
- Organizer
  第84回日本動物学会大会
- Place of Presentation
  岡山大学（岡山）
- Data Source
  KAKENHI-PROJECT-24570078
[Presentation] トランスジェニックカエルは２度輝く：変態期の消化管上皮幹細胞の起源と発生のメカニズム
- Author(s)
  長谷部孝、岡敦子
- Organizer
  第83回日本動物学会大会
- Place of Presentation
  大阪大学（大阪）
- Invited
- Data Source
  KAKENHI-PROJECT-24570078
[Presentation] AR遺伝子を導入したトランスジェニックツチガエルの作製
- Author(s)
  藤井　淳、児玉万穂、長谷部　孝、岡　敦子、中村正久
- Organizer
  日本動物学会第83回大会
- Place of Presentation
  大阪市、大阪大学
- Data Source
  KAKENHI-PROJECT-22370027

1. OKA Atsuko (50175254)

# of Collaborated Projects: 3 results

# of Collaborated Products: 60 results
2. NAKAMURA MASAHISA (40130025)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. FUJIMOTO Kenta (50403580)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
4. 松田洋一 (70165835)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. BUCHHOLZ Daniel R.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 川上浩一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hasebe Takashi 長谷部 孝

HASEBE Takashi 長谷部 孝

Research Projects

Research Products

Co-Researchers

小腸上皮幹細胞の追跡と空間遺伝子発現解析による幹細胞特異的遺伝子の探索と機能解析Principal Investigator

Principal Investigator

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Review Section

Research Institution

Identification of genes specific to the intestinal epithelial stem cells and their functional analysis by making use of transgenic frogsPrincipal Investigator

Principal Investigator

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Research Institution

Lineage analysis of intestinal stem cells and development of the culture system to study the stem cell niche

Principal Investigator

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Research Field

Research Institution

Origin of the adult epithelial stem cell in the Xenopus laevis intestine and the role of Notch signaling in the stem cell regulationPrincipal Investigator

Principal Investigator

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Research Field

Research Institution

Molecular mechanisms of development of the stem cell niche regulating intestinal epithelial dedifferentiation

Principal Investigator

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Research Institution

The study for the mechanism of steroid hormone-dependent sex determination in amphibians

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of the intestinal epithelial stem cell niche using transgenic frogs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Stem cell development involves divergent thyroid hormone receptor subtype expression and epigenetic modifications in the Xenopus metamorphosing intestine2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Thyroid hormone-induced expression of Foxl1 in subepithelial fibroblasts correlates with adult stem cell development during Xenopus intestinal remodeling2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expression of hyaluronan synthases upregulated by thyroid hormone is involved in intestinal stem cell development during Xenopus laevis metamorphosis2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Thyroid hormone-induced activation of Notch signaling is required for adult intestinal stem cell development during Xenopus laevis metamorphosis2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Functional analysis of thyroid hormone receptor beta in Xenopus tropicalis founders using CRISPR-Cas2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Essential roles of thyroid hormone-regulated hyaluronan/CD44 signaling in adult stem cell development during Xenopus laevis intestinal remodeling2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Thyroid hormone activates Wnt/beta-catenin signaling involved in adult epithelial development during intestinal remodeling in Xenopus laevis2016

Author(s)

Journal Title

Hasebe Takashi 長谷部孝

HASEBE Takashi 長谷部孝