Tsuzuki Takashi 都築尊

… Alternative Names

都築尊ツヅキタカシ

TSUZUKI Takashi 都築尊

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Researcher Number	70330967
Other IDs
External Links
Affiliation (Current)	2025: 福岡歯科大学, 口腔歯学部, 教授
Affiliation (based on the past Project Information) *help	2025: 福岡歯科大学, 口腔歯学部, 教授 2019 – 2023: 福岡歯科大学, 口腔歯学部, 教授 2016 – 2017: 福岡歯科大学, 口腔歯学部, 准教授 2015: 福岡歯科大学, 歯学部, 講師 2005 – 2010: 福岡歯科大学, 歯学部, 講師 2008: Fukuoka Dental College, 咬合修復学講座, 講師 2001 – 2004: 福岡歯科大学, 歯学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 57050:Prosthodontics-related / 補綴理工系歯学 Except Principal Investigator 補綴理工系歯学 / Basic Section 57050:Prosthodontics-related / 補綴理工系歯学 / Prosthodontics/ Dental materials science and
Keywords	Principal Investigator 認知症 / 認知機能 / 口腔ケア / 線維結合コラーゲン / 脳血流量 / 認知症モデルマウス / 口腔粘膜刺激 / オキシトシン / アミロイド / イオンチャネル … More / 口腔上皮細胞 / 歯肉上皮細胞 / 口腔粘膜 / メカノストレス / 低分子量プロテオグリカン / 歯根膜細胞 / 非外科学 / 非外科的 / 歯学 / 修復 / 咬合性外傷 / ストレス / 膝関節 / タイプIIコラーゲン / 変形性顎関節症モデルマウス / 顎骨 / 軟骨肥大 / 老化促進モデルマウス / 免疫組織学 / XIV型コラーゲン / XII型コラーゲン / IX型コラーゲン / 機械的刺激 / 骨硬化 / 老化促進マウス / 変形性顎関節症 … More Except Principal Investigator コラーゲン / 遺伝子発現 / 骨粗鬆症 / 老化促進マウス / 大腿骨 / 下顎骨 / リジルハイドロキシラーゼ / 骨質 / 変形性顎関節症 / 認知機能 / IL-1β / 認知能 / アミロイドβ / 軽度認知障害 / 咬合不調和 / collagen / 骨芽細胞 / proteoglycan / 骨 / 骨髄 / プロテオグリカン / 骨基質 / 皮質骨 / インプラント / コラーゲン架橋 / マウス / ルミカン / フィブロモデリン / バイグリカン / デコリン / 低分子量プロテオグリカン / アルカリフォスファターゼ / I型コラーゲン / 顎骨 / AGEｓ / 咀嚼機能 / 軽度認知症 / 軽度認知障害(MCI) / 認知能抑制物質 / 認知能低下 / アミロイドβ前駆体 / 過剰咬合 / リン酸化タウ / アルツハイマー型認知症 / SDF-1 / 咬合力 / bone morphometry / mandible / hydroxylation / lysine / senescence-accelerated mouse / osteoporosis / 老年性骨粗鬆症 / 破骨細胞 / 海綿骨 / リシン基の水酸化 / コラーゲン線維 / 骨形態計測 / ハイドロキシル化 / リシン / matrix metalloproteinase / lysyl hydroxylase / mineralization / osteoblast / bone / implant / TIMP / チタン / MMP / 石灰化 / temporomandibular joint / gene expression / protein distribution / bone marrow / cartilage / glycosaminoglycan / osteoarthritis / 加齢 / 成長板軟骨 / 膝関節 / ケラタン硫酸 / コンドロイチン4硫酸 / 関節軟骨 / 老化促進モデルマウス / 顎関節 / 蛋白分布 / 軟骨 / グリコサミノグリカン / 骨代謝回転 / 骨膜 / 水酸化リシン / ミネラル / 上腕骨 / リジン残基の水酸化 / 線維芽細胞 / 軟組織 / 術前診断 / 結合組織 / 歯肉 / エラスチン / III型コラーゲン / 代謝回転 / ハイドロキシリシン / 歯槽粘膜 / 角化歯肉 Less

Elucidation of the Mechanism by Which Oral Care Improves Hypoxic Conditions in the BrainPrincipal Investigator
- Principal Investigator
  
  都築尊
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  Fukuoka Dental College
The mechanism and its prevention in AGE-dependent cognitive dysfunction induced by mastication impairment
- Principal Investigator
  
  後藤加寿子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  Fukuoka College of Health Sciences
絆ホルモンによる認知機能低下抑制機序の解明　幸せな人生100年時代の実現Principal Investigator
- Principal Investigator
  
  都築尊
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  Fukuoka Dental College
軽度認知障害時における咬合不調和の認知症の発症因子としての同定とその機序の探索
- Principal Investigator
  
  後藤加寿子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  Fukuoka College of Health Sciences
The mechanism of Alzheimer disease development induced by IL-1beta during occlusal disharmony
- Principal Investigator
  
  Kajiya Hiroshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  Fukuoka Dental College
Elucidation of molecular mechanism in which the mechano-stress inhibit cognitive function decline.Principal Investigator
- Principal Investigator
  
  Tsuzuki Takashi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  Fukuoka Dental College
The role of SDF-1 in occlusal trauma-resistant maintenance of jaw bone quality
- Principal Investigator
  
  KAZUKO GOTO-T
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Prosthodontics/ Dental materials science and
- Research Institution
  Fukuoka College of Health Sciences
Analysis of jaw bone periosteum for prognosis of dental implant outcome
- Principal Investigator
  
  MATSUURA Takashi
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  補綴理工系歯学
- Research Institution
  Fukuoka Dental College
A develop of non-surgical repair method for occlusal traumaPrincipal Investigator
- Principal Investigator
  
  TSUZUKI Takashi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  補綴理工系歯学
- Research Institution
  Fukuoka Dental College
審美的・機能的歯肉獲得法開発のための生物学的研究
- Principal Investigator
  
  佐藤博信
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  補綴理工系歯学
- Research Institution
  Fukuoka Dental College
インプラント周囲軟組織の術前診断法の開発
- Principal Investigator
  
  松永興昌
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  補綴理工系歯学
- Research Institution
  Fukuoka Dental College
Basic research for development of diagnosis of jaw bone quality
- Principal Investigator
  
  SATO Hironobu
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  補綴理工系歯学
- Research Institution
  Fukuoka Dental College
骨硬化が変形性顎関節症を引き起こす可能性Principal Investigator
- Principal Investigator
  
  都築尊
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  補綴理工系歯学
- Research Institution
  Fukuoka Dental College
Mechanism of formation and maintenance of bone-implant interface structure.
- Principal Investigator
  
  MATSUURA T
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  補綴理工系歯学
- Research Institution
  Fukuoka Dental College
インプラント予後診断のための分子生物学的技法を用いた新しい顎骨骨質診断法の開発
- Principal Investigator
  
  SATO Hironobu
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  補綴理工系歯学
- Research Institution
  Fukuoka Dental College
Biological analyses of articular disk of temporomandibular joint and the adjacent tissues during growth and senescence.
- Principal Investigator
  
  SATO Hironobu
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  補綴理工系歯学
- Research Institution
  Fukuoka Dental College

All 2024 2023 2022 2021 2019 2017 2016 2008 2006 2005 2004

All Journal Article Presentation

[Journal Article] Occlusal disharmony transiently decrease cognition via cognitive suppressor molecules and partially restores cognitive ability via clearance molecules.2022
- Author(s)
  Maeshiba M, Kajiya H, Tsutsumi T, Migita K, Goto-T K, Kono Y, Tsuzuki T, Ohno J
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 594 Pages: 74-80
- DOI
  10.1016/j.bbrc.2022.01.048
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09567, KAKENHI-PROJECT-19K10234, KAKENHI-PROJECT-21K09990, KAKENHI-PROJECT-21K09948, KAKENHI-PROJECT-19K19113
[Journal Article] The Stromal Cell-derived Factor-1 Expression Protected in Periodontal Tissues Damage during Occlusal Traumatism2021
- Author(s)
  Kazuko T Goto, Hiroshi Kajiya, Takashi Tsutsumi, Munehisa Maeshiba, Takashi Tsuzuki, Kimiko Ohgi, Minoru Kawaguchi, Jun Ohno, Koji Okabe
- Journal Title
  
  Journal of Hard Tissue Biology
  
  Volume: 30 Pages: 63-68
- NAID
  130007975648
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K10234
[Journal Article] Establishment of a standardized cell culture system on acrylic resin2019
- Author(s)
  Tsutsumi T, Tsuzuki T, Kajiya H, Goto. T. Kazuko, Tashiro S, Maeshiba M
- Journal Title
  
  福岡歯科大学学会雑誌
  
  Volume: 45 Pages: 75-83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K10234
[Journal Article] Hyperocclusion stimulates the expression of collagen type XII in periodontal ligament.2016
- Author(s)
  Tsuzuki T, Kajiya H, T-Goto K, Tsutsumi T, Nemoto T, Okabe K, Takahashi Y.
- Journal Title
  
  Arch Oral Biol
  
  Volume: 66 Pages: 86-91
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11187
[Journal Article] 変形性顎関節症および骨粗鬆症を有する老化促進マウス(SAMP8、SAMP6)の下顎骨の骨形態計測学的特徴の比較検討2006
- Author(s)
  大郷友規, 松浦尚志, 片渕三千綱, 徳富健太郎, 都築尊, 石川昌嗣, 佐藤博信
- Journal Title
  
  第一回国際顎関節学会ならびに第19回日本顎関節学会総会・学術大会プログラム抄録集 19
  
  Pages: 123-123
- Data Source
  KAKENHI-PROJECT-18791469
[Journal Article] 老年性骨粗鬆症および変形性顎関節症モデルマウス(老化促進マウス)の下顎骨の骨形態計測学的解析2005
- Author(s)
  大郷友規, 松浦尚志, 徳富健太郎, 都築尊, 佐藤博信
- Journal Title
  
  日本骨代謝学会雑誌 23
  
  Pages: 276-276
- Data Source
  KAKENHI-PROJECT-15791155
[Journal Article] Differential gene expression of collagen-binding small leucine-rich proteoglycans and lysyl hydroxylases, during mineralization by MC3T3-E1 cells cultured on titanium implant material2005
- Author(s)
  Matsuura T, Tsubaki S, Tsuzuki T, Durarte WR, Yamauchi M, Sato H
- Journal Title
  
  European Journal of Oral Sciences 113
  
  Pages: 225-231
- Data Source
  KAKENHI-PROJECT-15390603
[Journal Article] Differential gene expression of collagen-binding small leucine-rich proteoglycans and lysyl hydroxylases during mineralization by MC3T3-E1 cells cultured on titanium implant material2005
- Author(s)
  Matsuura T, Tsubaki S, Tsuzuki T, Duarte WR, Yamauchi M, Sato H
- Journal Title
  
  European Journal of Oral Sciences (In press)
- Data Source
  KAKENHI-PROJECT-15390603
[Journal Article] Distribution of glycosaminoglycans in an early osteoarthritis-like lesion in the mandibular condyle cartilage of senescence-accelerated mice.2004
- Author(s)
  Kuramoto S, Matsuura T, Tsuzuki T, Sato H
- Journal Title
  
  Oral Medicine and Pathology 9
  
  Pages: 75-80
- Data Source
  KAKENHI-PROJECT-15791155
[Presentation] Tooth loss upregulated the expression of phosphorylated tau in hippocampus and suppressed cognitive ability in Alzheimer's model mice.2024
- Author(s)
  Maeshiba M, Kajiya H, Migita K, Goto-T K, Egashira K, Fujita T, Tsuzuki T
- Organizer
  第101回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-21K09990
[Presentation] Tooth loss upregulated the expression of phosphorylated tau in hippocampus and suppressed cognitive ability in Alzheimer's model mice.2024
- Author(s)
  Munehisa Maeshuba, Hiroshi Kajiya, Keisuke Migita, Kazuko Goto-T, Kei Egashira, Tsugumi Fujita, Takashi Tsuzuki
- Organizer
  第101回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-22K10090
[Presentation] 認知症における危険因子としての咬合不正の影響2023
- Author(s)
  前芝宗尚、鍛治屋浩、堤貴司、右田啓介、後藤加寿子、河野祐里、江頭敬、都築尊、大野純
- Organizer
  第100回日本生理学会
- Data Source
  KAKENHI-PROJECT-22K10090
[Presentation] 認知症における危険因子としての咬合不正の影響2023
- Author(s)
  前芝宗尚、鍛治屋浩、堤貴司、右田啓介、後藤加寿子、河野祐里、江頭敬、都築尊、大野純
- Organizer
  第100回日本生理学会
- Data Source
  KAKENHI-PROJECT-21K09990
[Presentation] 過剰咬合による認知機能の抑制効果について2023
- Author(s)
  前芝宗尚, 堤貴司, 後藤加寿子, 西村朋子, 吉田兼義, 中四良, 都築尊
- Organizer
  日本歯科補綴学会第132回学術大会
- Data Source
  KAKENHI-PROJECT-22K10090
[Presentation] Occlusal Disharmony Decreases Cognition via Cognitive Suppressor Molecules2022
- Author(s)
  Maeshuba M, Kajiya H, Tsutsumi T, Goto-T K, Okamoto F, Okabe K, Tsuzuki T, Ohno J
- Organizer
  第99回日本生理学会
- Data Source
  KAKENHI-PROJECT-21K09990
[Presentation] 咬合不正により引き起こされる認知症誘発物質の発現増加について2021
- Author(s)
  前芝　宗尚、堤　貴司、吉田兼義、長谷英明、木山賢歩、都築　尊
- Organizer
  一般社団法人日本老年歯科医学会第32回学術大会
- Data Source
  KAKENHI-PROJECT-19K10234
[Presentation] 歯肉刺激モデル動物における分子生物学的検討2021
- Author(s)
  都築　尊、前芝宗尚、後藤加寿子、堤　貴司、平川直毅、松瀬智樹、平　貴文、宮尾知佐
- Organizer
  第130回日本補綴歯科学会学術大会（web）
- Data Source
  KAKENHI-PROJECT-19K10234
[Presentation] 歯肉刺激モデル動物における分子生物学的検討2021
- Author(s)
  都築　尊、前芝宗尚、後藤加寿子、堤　貴司、平川直毅、松瀬智樹、平　貴文、宮尾知佐
- Organizer
  公益社団法人日本補綴歯科学会第130回記念学術大会
- Data Source
  KAKENHI-PROJECT-19K10234
[Presentation] 咬合不正と認知機能との関連性について2021
- Author(s)
  前芝　宗尚、堤　貴司、後藤加寿子、都築　尊、吉田兼義、小柳進祐、中　四良、都築　尊
- Organizer
  公益社団法人日本補綴歯科学会第130回記念学術大会
- Data Source
  KAKENHI-PROJECT-19K10234
[Presentation] アルツハイマー病における認知機能と咬合力との関連性について2019
- Author(s)
  前芝　宗尚，鍛治屋　浩，堤　貴司，都築　尊，大野　純，髙橋　裕
- Organizer
  福岡歯科大学学会総会
- Data Source
  KAKENHI-PROJECT-19K10234
[Presentation] 咬合不正による認知機能の低下作用2019
- Author(s)
  前芝宗尚、堤　貴司、都築　尊、髙橋　裕
- Organizer
  第30回日本老年歯科医学会学術大会
- Data Source
  KAKENHI-PROJECT-19K10234
[Presentation] メカニカルストレスにおける幹細胞関連ケモカインSDF-1とCXCR4の発現相関2017
- Author(s)
  後藤加寿子, 都築尊, 堤貴司, 佐藤博信
- Organizer
  第126回日本補綴歯科学会学術講演会
- Data Source
  KAKENHI-PROJECT-15K11187
[Presentation] マイクロCTを用いた咬合性外傷モデルにおける歯槽骨吸収量の定量的解析2017
- Author(s)
  堤貴司, 都築尊, 後藤加寿子, 池浦政裕, 勝俣辰也, 高橋裕
- Organizer
  日本補綴歯科学会九州支部学術大会
- Data Source
  KAKENHI-PROJECT-15K11187
[Presentation] 歯根膜組織の線維結合型コラーゲン発現の減少がメカニカルストレス感受性に及ぼす影響2017
- Author(s)
  都築尊, 後藤加寿子, 堤貴司, 新郷由紀子, 中四良, 高橋裕
- Organizer
  第126回日本補綴歯科学会学術講演会
- Data Source
  KAKENHI-PROJECT-15K11187
[Presentation] 歯根膜組織の線維結合型コラーゲン12発現の減少が咬合性メカニカルストレスに対する抵抗性を減弱させる2016
- Author(s)
  都築　尊
- Organizer
  日本骨代謝学会学術集会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-15K11187
[Presentation] コーヌステレスコープ義歯により清掃性と装着感に考慮した症例2008
- Author(s)
  都築尊
- Organizer
  平成20年日本補綴歯科学会九州中国四国支部合同学術大会
- Year and Date
  2008-08-30
- Data Source
  KAKENHI-PROJECT-18791469
[Presentation] コーヌステレスコープ義歯の長期経過症例2008
- Author(s)
  都築尊,松山繁樹,清國祐紀,田代琢二,根本哲臣,清水博史,高橋裕
- Organizer
  第35回福岡歯科大学学会総会
- Year and Date
  2008-12-14
- Data Source
  KAKENHI-PROJECT-18791469
[Presentation] コーヌステレスコープ義歯により清掃性と装着感に考慮した症例2008
- Author(s)
  都築尊
- Organizer
  日本補綴歯科学会九州中国四国支部合同学術大会
- Place of Presentation
  大分県
- Year and Date
  2008-08-30
- Data Source
  KAKENHI-PROJECT-18791469

1. MATSUURA Takashi (60330966)

# of Collaborated Projects: 7 results

# of Collaborated Products: 2 results
2. KAZUKO GOTO-T (60389418)

# of Collaborated Projects: 7 results

# of Collaborated Products: 11 results
3. SATO Hironobu (00145955)

# of Collaborated Projects: 6 results

# of Collaborated Products: 2 results
4. MATSUNAGA Tatsuaki (50389409)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. Kajiya Hiroshi (80177378)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. 堤貴司 (70736652)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
7. 前芝宗尚 (90964338)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
8. KATAFUCHI Michitsuna (90454933)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 石川昌嗣 (20369044)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. GOTO Kazuko (60389468)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TOKUTOMI Kentaro (20508981)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. UKON S (70038876)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TAKAHASHI Y (50154878)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SHIMIZU H (80162709)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 松浦正朗 (10089451)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 城戸寛史 (90169897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 椿賢 (90341487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 生山隆 (00389412)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 大野純 (10152208)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
20. YAMAUCHI Mitsuo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. SASAKI Michiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 鍛冶屋浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results

Tsuzuki Takashi 都築 尊

都築 尊 ツヅキ タカシ

TSUZUKI Takashi 都築 尊

Research Projects

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Elucidation of the Mechanism by Which Oral Care Improves Hypoxic Conditions in the BrainPrincipal Investigator

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絆ホルモンによる認知機能低下抑制機序の解明 幸せな人生100年時代の実現Principal Investigator

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Elucidation of molecular mechanism in which the mechano-stress inhibit cognitive function decline.Principal Investigator

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A develop of non-surgical repair method for occlusal traumaPrincipal Investigator

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骨硬化が変形性顎関節症を引き起こす可能性Principal Investigator

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Tsuzuki Takashi 都築尊

都築尊ツヅキタカシ

TSUZUKI Takashi 都築尊

絆ホルモンによる認知機能低下抑制機序の解明　幸せな人生100年時代の実現Principal Investigator