HINOU Hiroshi 比能洋

… Alternative Names

Researcher Number	70333333
Other IDs
External Links
Affiliation (Current)	2021: 北海道大学, 先端生命科学研究院, 教授
Affiliation (based on the past Project Information) *help	2018 – 2020: 北海道大学, 先端生命科学研究院, 教授 2016 – 2017: 北海道大学, 先端生命科学研究院, 准教授 2013 – 2015: 北海道大学, 先端生命科学研究科(研究院), 准教授 2014: 北海道大学, 先端生命科学研究院, 助教 2012: 北海道大学, 先端生命科学研究科(研究院), 助教 … More
Review Section/Research Field	Principal Investigator Chemistry related to living body / Bio-related chemistry Except Principal Investigator Civil and environmental engineering / Chemical biology / Chemistry related to living body / Medium-sized Section 37:Biomolecular chemistry and related fields / Basic Section 38050:Food sciences-related
Keywords	Principal Investigator NMR / 糖ペプチド / 配座 / 自殺基質 / 機能選択的 / 特異的阻害 / 触媒部位の同定 / ラベル化 / 非特異的阻害 / 活性化速度 … More Except Principal Investigator グライコブロッティング法 / 抗体医薬 / 動的エピトープ / gold colloidal nanoparticle / carbohydrate / glycoblotting / suicide substrate / glycomics / quantum dots / live cell imaging / 膜ファウリング / ＭＢＲ / 多糖 / MBR / MALDI-TOF/MS / LPS / 多糖類 / グライコブロッティング / 加水分解 / 癌バイオマーカー / 癌早期発見 / 糖鎖解析 / 大規模糖鎖構造解析 / 糖鎖工学 / 疾患糖鎖データベース / 糖鎖 / グライコミクス / 疾患マーカー / 肝細胞癌 / 膵癌 / 腎細胞癌 / 早期診断法 / 診断薬探索 / ケミカルバイオロジー / 生体分子 / バイオマーカー / MALDT-TOF MS / carbohydrate binding protein / proteomics / glycosyltransferase / mass spectrometry / enzyme assay / glycosidase / gold collodial nanoparticle / MALDI-TOF MS / ED抗体 / 糖ペプチド抗原 / 構造生物学 / Dynamic epitope theory / Glycopeptidic epitope / Epitope defined antibody / Anti-MUC1 antibody / がん治療用抗体 / X線結晶構造解析 / 機能改変抗体 / 二重特異性抗体 / マンノ－ス / 免疫機能 / マンノース / 樹状細胞 / 免疫調整機能 / 免疫調製機能 / アレルギ－ Less

Antibodies targeting dynamic epitopes generated by posttranslational protein glycosylationOngoing
- Principal Investigator
  
  西村紳一郎
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  Hokkaido University
D-マンノ－ス骨格を持つ糖鎖による免疫・炎症反応制御とその分子基盤の解析Ongoing
- Principal Investigator
  
  戸田雅子
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Tohoku University
Multidimensional investigation of Glycopeptide-lectin interactionPrincipal Investigator
- Principal Investigator
  
  Hinou Hiroshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Hokkaido University
Exploration of Novel Markers on Cancer and Development of a Technology for the Diagnosis Utilized by Comprehensive Glycomics
- Principal Investigator
  
  Nishimura Shin-Ichiro
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Chemical biology
- Research Institution
  Hokkaido University
Control of membrane fouling based on structures of polysaccharides revealed by application of glyco-blotting
- Principal Investigator
  
  KIMURA Katsuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Civil and environmental engineering
- Research Institution
  Hokkaido University
Study for rapid synthesis and mechanism elucidation of cyclic antifreeze glycopeptidePrincipal Investigator
- Principal Investigator
  
  HINOU HIROSHI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Hokkaido University
Development of novel compound of function selective labeling reagent for proteins and its systematic usePrincipal Investigator
- Principal Investigator
  
  HINOU Hiroshi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Hokkaido University
Function search of glycoconjugates by selective laser desorption ionization mass spectronmeter using metal nanoparticle
- Principal Investigator
  
  NISIMURA Shin-ichitro
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Hokkaido University

[Book] Methods in Enzymology2006
- Author(s)
  Hinou H.
- Total Pages
  11
- Publisher
  Academic Press
- Data Source
  KAKENHI-PROJECT-17205015
[Book] Methods in Enzymology2006
- Author(s)
  Hinou, H.
- Total Pages
  11
- Publisher
  Academic Press
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17205015
[Journal Article] A straightforward approach to antibodies recognising cancer specific glycopeptidic neoepitopes2020
- Author(s)
  Wakui Hajime、Tanaka Yoshikazu、Ose Toyoyuki、Matsumoto Isamu、Kato Koji、Yao Min、Tachibana Taro、Sato Masaharu、Naruchi Kentaro、Garca-Martin Fayna、Hinou Hiroshi、Nishimura Shin-Ichiro
- Journal Title
  
  Chemical Science
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H00918
[Journal Article] Synthesis, conformational analysis and in vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment2020
- Author(s)
  Bermejo Iris A.、Navo Claudio D.、Castro-Lopez Jorge、Guerreiro Ana、Garcia-Martin Fayna、Hinou Hiroshi、Nishimura Shin-Ichiro、Mellet Carmen Ortiz、Avenoza Alberto、Busto Jeses H.、Corzana Francisco、et al.
- Journal Title
  
  Chemical Science
  
  Volume: 11 Pages: 3996-4006
- DOI
  10.1039/c9sc06334j
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H00918, KAKENHI-PROJECT-17K05920
[Journal Article] Impaired O-Glycosylation at Consecutive Threonine TTX Motifs in Mucins Generates Conformationally Restricted Cancer Neoepitopes2020
- Author(s)
  Hayakawa Shun、Matsushita Takahiko、Yokoi Yasuhiro、Wakui Hajime、Garcia-Martin Fayna、Hinou Hiroshi、Matsuoka Koji、Nouso Kazuhiro、Kamiyama Toshiya、Taketomi Akinobu、Nishimura Shin-Ichiro
- Journal Title
  
  Biochemistry
  
  Volume: 59 Pages: 1221-1241
- DOI
  10.1021/acs.biochem.0c00007
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H00918, KAKENHI-PROJECT-17K05920
[Journal Article] Synthetic glycopeptides reveal specific binding pattern and conformational change at O-mannosylated position of α-dystroglycan by POMGnT1 catalyzed GlcNAc modification2019
- Author(s)
  Hinou Hiroshi、Kikuchi Seiya、Ochi Rika、Igarashi Kota、Takada Wataru、Nishimura Shin-Ichiro
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 27 Pages: 2822-2831
- DOI
  10.1016/j.bmc.2019.05.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K05920
[Journal Article] Aniline derivative/DHB/alkali metal matrices for reflectron mode MALDI-TOF and TOF/TOF MS analysis of unmodified sialylated oligosaccharides and glycopeptides2019
- Author(s)
  Hinou Hiroshi
- Journal Title
  
  International Journal of Mass Spectrometry
  
  Volume: 443 Pages: 109-115
- DOI
  10.1016/j.ijms.2019.06.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K05920
[Journal Article] Glycan-immobilized dual-channel field effect transistor biosensor for the rapid identification of pandemic influenza viral particles2019
- Author(s)
  Hideshima Sho、Hayashi Hiroki、Hinou Hiroshi、Nambuya Shunsuke、Kuroiwa Shigeki、Nakanishi Takuya、Momma Toshiyuki、Nishimura Shin-Ichiro、Sakoda Yoshihiro、Osaka Tetsuya
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Pages: 11616-11616
- DOI
  10.1038/s41598-019-48076-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K05920
[Journal Article] Exploring serum and immunoglobulin G N-glycome as diagnostic biomarkers for early detection of breast cancer in Ethiopian women2019
- Author(s)
  Gebrehiwot Abrha G.、Melka Daniel Seifu、Kassaye Yimenashu Mamo、Gemechu Tufa、Lako Wajana、Hinou Hiroshi、Nishimura Shin-Ichiro
- Journal Title
  
  BMC Cancer
  
  Volume: 19
- DOI
  10.1186/s12885-019-5817-8
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K05920
[Journal Article] Glycoblotting of Egg White Reveals DiverseN-Glycan Expression in Quail Species2019
- Author(s)
  Jurgen T. Sanes, Hiroshi Hinou, Yuan Chuan Lee, Shin-Ichiro Nishimura
- Journal Title
  
  Journal of Agricultural and Food Chemistry
  
  Volume: 67 Pages: 531-540
- DOI
  10.1021/acs.jafc.8b04782
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K05920
[Journal Article] Healthy human serum N-glycan profiling reveals the influence of ethnic variation on the identified cancer-relevant glycan biomarkers2018
- Author(s)
  Abrha G. Gebrehiwot, Daniel Seifu Melka, Yimenashu Mamo Kassaye, Ibrahim F. Rehan, Shobith Rangappa, Hiroshi Hinou, Toshiya Kamiyama, Shin-Ichiro Nishimura
- Journal Title
  
  PLOS One
  
  Volume: 13
- DOI
  10.1371/journal.pone.0209515
- NAID
  120006650536
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K05920
[Journal Article] Synthetic Glycopeptides Allow for the Quantitation of Scarce Nonfucosylated IgG Fc N-Glycans of Therapeutic Antibody2018
- Author(s)
  Kazuki Hammura, Akari Ishikawa, Ravi H.V. Kumar, Risho Miyoshi, Yasuhiro Yokoi, Masakazu Tanaka, Hiroshi Hinou, Shin-Ichiro Nishimura
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 9 Pages: 889-894
- DOI
  10.1021/acsmedchemlett.8b00127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K05920
[Journal Article] Synthetic glycopeptides as a designated standard in focused glycoproteomics to discover serum cancer biomarkers2018
- Author(s)
  Yogesh K. V., Toshiya Kamiyama, Chikara Ohyama, Tohru Yoneyama, Kazuhiro Nouso, Satoshi Kimura, Hiroshi Hinou, Shin-Ichiro Nishimura
- Journal Title
  
  MedChemComm
  
  Volume: 9 Pages: 1351-1358
- DOI
  10.1039/c8md00162f
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K05920, KAKENHI-PROJECT-18K09157, KAKENHI-PROJECT-15H02563
[Journal Article] Further applications of classical amide coupling reagents: microwave-assisted esterification on solid-phase2018
- Author(s)
  Risa Takayama, Shun Hayakawa, Hiroshi Hinou, Fernando Albericio, Fayna Garcia-Martin
- Journal Title
  
  Journal of Peptide Science
  
  Volume: 24
- DOI
  10.1002/psc.3111
- NAID
  120006709284
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K05920
[Journal Article] Chemical synthesis demonstrates dynamic O-glycosylation regulates folding and functional conformation of a pivotal EGF12 domain of human NOTCH1 receptor2017
- Author(s)
  Hayakawa S., Yokoi Y., Hinou H., Nishimura S-I.
- Journal Title
  
  Biochemistry
  
  Volume: 56 Pages: 4379-4391
- DOI
  10.1021/acs.biochem.7b00372
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25220206, KAKENHI-PROJECT-17K05920
[Journal Article] An efficient glycoblotting-based analysis of oxidized lipids in liposomes and a lipoprotein2017
- Author(s)
  Furukawa Takayuki、Hinou Hiroshi、Takeda Seiji、Chiba Hitoshi、Nishimura Shin-Ichiro、Hui Shu-Ping
- Journal Title
  
  ChemBioChem
  
  Volume: 18 Pages: 1903-1909
- DOI
  10.1002/cbic.201700384
- NAID
  120006528256
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15766, KAKENHI-PROJECT-25220206
[Journal Article] Synthetic Mucin-like Glycopeptides as Versatile Tools to Measure Effects of Glycan Structure/Density/Position on Interaction with Adhesion/Growth-regulatory Galectins in Arrays2017
- Author(s)
  Artigas G., Hinou H., Garcia-Martin F., Hans-Joachim Gabius and Nishimuera S-I.
- Journal Title
  
  Chemistry: An Asian Journal
  
  Volume: 12 Pages: 159-167
- DOI
  10.1002/asia.201601420
- NAID
  120006374980
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220206, KAKENHI-PROJECT-17K05920
[Journal Article] The use of fluoroproline in MUC1 antigen enables efficient detection of antibodies in patients with prostate cancer2017
- Author(s)
  Somovilla V.J., Bermeijo I.A., Albuquerque I.S., Martinez S. N., Castro Lopez J., Garcia Martin F., Companon I., Hinou H., Nishimura S-I., Jimenez Barbero J., Asensio J.L, Avenoza G., Busto J.H., Hurtado-Guerrero. R., Peregrina J.M., Bernardes G.J.L., Corzana F.
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 129 Pages: 18255-18261
- DOI
  10.1021/jacs.7b09447
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220206, KAKENHI-PROJECT-17K05920
[Journal Article] Glycopeptides as Targets for Dendritic Cells: Exploring MUC1 Glycopeptides Binding Profile Towards Macrophage Galactose-Type Lectin (MGL) Orthologs2017
- Author(s)
  Artigas G., Monteiro J.T., Hinou H., Nishimura S-I, Lepenies B., and Garcia Martin F.
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 60 Pages: 9012-9021
- DOI
  10.1021/acs.jmedchem.7b01242
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220206, KAKENHI-PROJECT-17K05920
[Journal Article] Novel β-galactosynthase - β-mannosynthase dual activity of β-galactosidase from Aspergillus oryzae uncovered using monomer sugar substrates2016
- Author(s)
  Roger S. Tan, Hinou H., and Nishimura S-I.
- Journal Title
  
  RSC Adv.
  
  Volume: 6 Pages: 50833-50836
- DOI
  10.1039/c6ra08060j
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220206
[Journal Article] Convergent solid-phase synthesis of macromolecular MUC1 models truly mimicking serum glycoprotein biomarkers of interstitial lung diseases2016
- Author(s)
  Ohyabu N, Kakiya K., Yokoi Y., Hinou H., Nishimura S-I.
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 138 Pages: 8392-8395
- DOI
  10.1021/jacs.6b04973
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25220206
[Journal Article] Glycoblotting method allows for rapid and efficient glycome profiling of human Alzheimer’s disease brain, serum and cerebrospinal fluid towards potential biomarker discovery2016
- Author(s)
  Gizaw S., Ohashi T., Tanaka M., Hinou H., Nishimura S-I.
- Journal Title
  
  BBA-GenSubjects
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25220206
[Journal Article] Synthetic Human NOTCH1 EGF Modules Unraveled Molecular Mechanisms for the Structural and Functional Roles of Calcium Ions and O-glycans in the Ligand-binding Region2016
- Author(s)
  Hayakawa S., Koide R., Hinou H., Nishimura S-I.
- Journal Title
  
  Biochemistry
  
  Volume: 55 Pages: 776-787
- DOI
  10.1021/acs.biochem.5b01284
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25220206
[Journal Article] Effects of the multiple O-glycosylation states on antibody recognition of the immunodominant motif in MUC1 extracellular tandem repeats2016
- Author(s)
  Rangappa S., Artigas G., Miyoshi R., Yokoi Y., Hayakawa S., Fayna Garcia-Martin, Hinou H., Nishimura S-I.
- Journal Title
  
  Medicinal Chemistry Communication
  
  Volume: 印刷中
- DOI
  10.1039/c6md00100a
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220206, KAKENHI-PROJECT-24710242
[Journal Article] Rapid Endolysosomal Escape and Controlled Intracellular Trafficking of Cell Surface Mimetic Quantum-Dots-Anchored Peptides and Glycopeptides2015
- Author(s)
  Roger S. Tan, Naruchi K., Amano M., Hinou H., Nishimura S-I.
- Journal Title
  
  ACS Chem. Biol.
  
  Volume: 10 Pages: 2073-2086
- DOI
  10.1021/acschembio.5b00434
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25220206
[Journal Article] Large-scale Glycomics of Livestock: Discovery of Highly Sensitive Serum Biomarkers Indicating an Environmental Stress Affecting Immune Responses and Productivity of Holstein Dairy Cows2015
- Author(s)
  Rehan I., Ueda K., Mitani T., Amano M., Hinou H, Ohashi T., Kondo S., and Nishimura S-I.
- Journal Title
  
  J. Agric. Food. Chem.
  
  Volume: 63 Pages: 10578-10590
- DOI
  10.1021/acs.jafc.5b04304
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25220206
[Journal Article] A comprehensive glycome profiling of Huntington's disease transgenic mice2015
- Author(s)
  Gizaw S., Koda T., Amano M., Kamimura K., Ohashi T., Hinou H., Nishimura S-I.
- Journal Title
  
  BBA-GenSubjects
  
  Volume: 1850 Pages: 1704-1715
- DOI
  10.1016/j.bbagen.2015.04.006
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25220206
[Journal Article] Fast epitope mapping for the anti-MUC1 monoclonal antibody by combining one-bead-one-glycopeptide library and microarray platform2014
- Author(s)
  Fayna Garcia-Martin, Takahiko Matsushita, Hiroshi Hinou, and Shin-Ichiro Nishimura
- Journal Title
  
  Chem. Eur. J.
  
  Volume: 20 Pages: 15891-15902
- DOI
  10.1002/chem.201403239
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24710242, KAKENHI-PROJECT-25220206
[Journal Article] A straightforward protocol for the preparation of high performance microarray displaying synthetic MUC1 glycopeptides2014
- Author(s)
  Takahiko Matsushita, Wataru Takada, Kota Igarashi, Kentaro Naruchi, Fayna Garcia-Martin, Maho Amano, Hiroshi Hinou, Shin-Ichiro Nishimura
- Journal Title
  
  BBA-GenSubjects
  
  Volume: 59 Pages: 1105-1116
- DOI
  10.1016/j.bbagen.2013.11.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23350074, KAKENHI-PROJECT-24710242, KAKENHI-PROJECT-25220206
[Journal Article] Synthesis of neoglycosphingolipid from nethoxyamino-functionalized ceramide2014
- Author(s)
  Junya Ishida, Hiroshi Hinou, Kentaro Naruchi, Shin-Ichiro Nishimura
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 24 Pages: 1197-1200
- DOI
  10.1016/j.bmcl.2013.12.091
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23350074, KAKENHI-PROJECT-24651254
[Journal Article] Macrocyclic Mechanism-based Inhibitor for Neuraminidases2013
- Author(s)
  Hirokazu Kai, Hiroshi Hinou, Kentaro Naruchi, Takahiko Matsushita, and Shin-Ichiro Nishimura
- Journal Title
  
  Chem. Eur. J
  
  Volume: 19 Pages: 1364-1372
- DOI
  10.1002/chem.201200859
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23350074, KAKENHI-PROJECT-24651254
[Journal Article] Site-specific conformational alteration induced by sialylation of MUC1 tandem repeating glycopeptides at an epitope region for anti-KL-6 monoclonal antibody2013
- Author(s)
  Takahiko Matsushita, Naoki Ohyabu, Naoki Fujitani, Kentaro Naruchi, Hiroki Shimizu, Hiroshi Hinou, Shin-Ichiro Nishimura
- Journal Title
  
  Biochemistry
  
  Volume: 52 Pages: 402-414
- DOI
  10.1021/bi3013142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23350074
[Journal Article] Attomolar Detection of Influenza A Virus Hemagglutinin Human H1 and Avian H5 Using Glycan-Blotted Field Effect Transistor Biosensor2013
- Author(s)
  Sho Hideshima, Hiroshi Hinou, Daisuke Ebihara, Ryosuke Sato, Shigeki Kuroiwa, Takuya Nakanishi, Shin-Ichiro Nishimura, Tetsuya Osaka
- Journal Title
  
  Anal. Chem.
  
  Volume: 85 Pages: 5641-5644
- DOI
  10.1021/ac401085c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23350074, KAKENHI-PROJECT-24500519, KAKENHI-PROJECT-24651254, KAKENHI-PROJECT-24710136, KAKENHI-PROJECT-25220206
[Journal Article] Microwave-assisted solid-phase synthesis of antifreeze glycopeptides2013
- Author(s)
  Izumi, R., Matsushita, T., Ohyabu, N., Fujitani, N., Naruchi, K., Shimizu, H., Tsuda, S., Hinou, H., and Nishimura, S.-I
- Journal Title
  
  Chemistry : A European Journal
  
  Volume: 19 Pages: 3913-3920
- DOI
  10.1002/chem.201203731
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310171, KAKENHI-PROJECT-23350074
[Journal Article] A New Approach for the Synthesis of Hyper-Branched N-Glycan Core Structures from Locust Bean Gum2013
- Author(s)
  H. V. Ravi Kumar, Kentaro Naruchi, Risho Miyoshi, Hiroshi Hinou, Shin-Ichiro Nishimura
- Journal Title
  
  Org. Lett.
  
  Volume: 15 Pages: 6278-6281
- DOI
  10.1021/ol403140h
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23350074, KAKENHI-PROJECT-24651254, KAKENHI-PROJECT-25220206
[Journal Article] Glycoblotting-based high throughput protocol for the structural characterization of hyaluronan degradation products during enzymatic fragmentation2013
- Author(s)
  Takayuki Furukawa, Misaki Arai, Fayna G. Martin, Maho Amano, Hiroshi Hinou, Shin-Ichiro Nishimura
- Journal Title
  
  Glycoconjugate Journal
  
  Volume: 30 Pages: 171-182
- DOI
  10.1007/s10719-012-9395-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23350074
[Journal Article] A novel approach for the parallel synthesis of glycopeptides by combining solid-phase peptide synthesis and dendrimer-supported enzymatic modifications2013
- Author(s)
  Takahiko Matsushita, Seiji Handa, Kentaro Naruchi, Fayna Garcia-Martin, Hiroshi Hinou
- Journal Title
  
  Polymer Journal
  
  Volume: 45 Pages: 854-862
- DOI
  10.1038/pj.2013.14
- NAID
  10031188169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23350074, KAKENHI-PROJECT-24710242
[Journal Article] Strict stereocontrol by 2, 4-O-di-tert-butylsilylene group on β-glucuronylations2012
- Author(s)
  Takayuki Furukawa, Hiroshi Hinou, Shin-Ichiro Nishimura
- Journal Title
  
  Organic Letters
  
  Volume: 14 Pages: 2102-2105
- DOI
  10.1021/ol300634x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23350074
[Journal Article] H-Bonding Promotion of Peptide Solubility and Cyclization by Fluorinated Alcohol2012
- Author(s)
  Hiroshi Hinou, Kei Hyugaji, Fayna Garcia-Martin, Shin-Ichiro Nishimura, Fernando Albericio
- Journal Title
  
  RSC Advances
  
  Volume: 2 Pages: 2729-2731
- DOI
  10.1039/c2ra01043g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23350074
[Journal Article] An efficient protocol for the solid-phase synthesis of glycopeptides under microwave irradiation2012
- Author(s)
  Fayna Garcia-Martin, Hiroshi Hinou, Takahiko Matsushita, Shun Hayakawa, Shin-Ichiro Nishimura
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 10 Pages: 1612-1617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23350074
[Journal Article] Aglycone-focused randomization of 2-difluoromethylphenylsialoside-type suicide substrates for neuraminidases2012
- Author(s)
  Hirokazu Kai, Hiroshi Hinou, Shin-Ichiro Nishimura
- Journal Title
  
  Bioorgan. Med. Chem
  
  Volume: 20 Pages: 2739-2746
- DOI
  10.1016/j.bmc.2012.02.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23350074, KAKENHI-PROJECT-24651254
[Journal Article] A Potential Glucuronate Glycosyl Donor with 2-O-acyl-6,3-lactone Structure : Efficient Synthesis of Glycosaminoglycan Disaccharides2011
- Author(s)
  古川貴之、比能洋、島脇健、西村紳一郎
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 52 Pages: 5567-5570
- DOI
  10.1016/j.tetlet.2011.08.024
- NAID
  120003537883
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23350074
[Journal Article] Toward Green and Sustainable Chemical Glycosylation : Enhanced Lewis Acidity of Recyclable Solid Super Acid Catalyst, SO_4/ZrO_2 by CaCl_2 Doping2011
- Author(s)
  比能洋、斉藤尚裕、前田哲宏、神谷裕一、西村紳一郎
- Journal Title
  
  Journal of Carbohydrate Chemistry
  
  Volume: 30 Pages: 575-586
- DOI
  10.1080/07328303.2011.610545
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23350074
[Journal Article] Mechanism-based Probing, Characterization, and Inhibitor Design of Glycosidases and Glycosyltransferases2010
- Author(s)
  Hiroshi Hinou, Hirokazu Kai, Shin-Ichiro Nishimura
- Journal Title
  
  Methods in Molecular Biology (In press)
- Data Source
  KAKENHI-PROJECT-19685015
[Journal Article] Potent inhibitor scaffold against Trypanosoma cruzi trans-sialidase2010
- Author(s)
  Shingo Arioka, Masahiro Sakagami, Rie Uematsu, Hiroto Yamaguchi, Hiroko Togame, Hiroshi Takemoto, Hiroshi Hinou, Shin-Ichiro Nishimura
- Journal Title
  
  Bioorganic & Medicinal Chemistry 18
  
  Pages: 1633-1640
- Data Source
  KAKENHI-PROJECT-19685015
[Journal Article] A new class of mechanism-based inhibitors for Trypanosoma cruzi trans-sialidase and their influence on parasite virulence2010
- Author(s)
  Sebastiao T Carvalho, Mauro Sola-Penna, Isadora A Oliveira, Samuel Pita, Arlan S Goncalves, Bianca C Neves, Francisco R Sousa, Leonardo Freire-de-Lima, Masaki Kurogochi, Hiroshi Hinou, Shin-Ichiro Nishimura, Lucia Mendonca-Previato, Jose O Previato, Adriane R Todeschini
- Journal Title
  
  Glycobiology (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19685015
[Journal Article] Potent inhibitor scaffold against Trypanosoma cruzi trans-sialidase2010
- Author(s)
  Shingo Arioka, Masahiro Sakagami, Rie Uematsu, Hiroto Yamaguchi, Hiroko Togame, Hiroshi Takemoto, Hiroshi Hinou, Shin-Ichiro Nishimura
- Journal Title
  
  Bioorganic & Medicinal Chemistry 118
  
  Pages: 633-1640
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19685015
[Journal Article] Lucia Mendonca-Previato, Jose O Previato, Adriane R Todeschini "A new class of mechanism-based inhibitors for Trypanosoma cruzi trans-sialidase and their influence on parasite virulence"2010
- Author(s)
  Sebastiao T Carvalho, Mauro Sola-Penna, Isadora A Oliveira, Samuel Pita, Arlan S Goncalves, Bianca C Neves, Francisco R Sousa, Leonardo Freire-de-Lima, Masaki Kurogochi, Hiroshi Hinou, Shin-Ichiro Nishimura
- Journal Title
  
  Glycobiology. (in press)
- Data Source
  KAKENHI-PROJECT-19685015
[Journal Article] Mechanism-Based Probing, Characterization, and Inhibitor Design of Glycosidases and Glycosyltransferases2009
- Author(s)
  Hiroshi Hinou, Shin-Ichiro Nishimura
- Journal Title
  
  Curr.Top.Med.Chem. 9
  
  Pages: 106-116
- Data Source
  KAKENHI-PROJECT-19685015
[Journal Article] Mechanism-Based Probing, Characterization, and Inhibitor Design of Glycosidases and Glycosyltransferases2009
- Author(s)
  Hiroshi Hinou, Shin-Ichiro Nishimura
- Journal Title
  
  Curr. Top. Med. Chem. 9
  
  Pages: 106-116
- Data Source
  KAKENHI-PROJECT-19685015
[Journal Article] Functional Neoglycopeptides: Synthesis and Characterization of New Class MUC1 Glycoprotein Models Having Core 2-based O-Glycan and Complex-type N-Glycan Chains2009
- Author(s)
  Takahiko Matsushita, Reiko Sadamoto, Naoki Oyabu, Hideki Nakata, Masataka Fumoto, Naoki Fujitani, Yasuhiro Takegawa, Takashi Sakamoto, Masaki Kurogochi, Hiroshi Hinou, Hiroki Shimizu, Takaomi Ito, Kentaro Naruchi, Hiroko Togame, HiroshiTakemoto, Hirosato Kondo, Shin-Ichiro Nishimura
- Journal Title
  
  Biochemistry 48
  
  Pages: 11117-11133
- Data Source
  KAKENHI-PROJECT-19685015
[Journal Article] One-pot synthesis of cyclic antifreeze glycopeptides2009
- Author(s)
  Masakazu Hachisu, Hiroshi Hinou, Manabu Takamichi, Sakae Tsuda, Shuhei Koshida, Shin-Ichiro Nishimura
- Journal Title
  
  Chem. Commun.
  
  Pages: 1641-1643
- Data Source
  KAKENHI-PROJECT-19685015
[Journal Article] An Essential Epitope of Anti-MUC1 Monoclonal Antibody KL-6 Revealed by Focused Glycopeptide Library2009
- Author(s)
  Naoki Ohyabu, Hiroshi Hinou, Takahiko Matsushita, Ryuko Izumi, Hiroki Shimizu, Keiko Kawamoto, Yoshito Numata, Hiroko Togame, Hiroshi Takemoto, Hirosato Kondo, Shin-Ichiro Nishimura
- Journal Title
  
  Journal of the American Chemical Society 131
  
  Pages: 17102-17109
- Data Source
  KAKENHI-PROJECT-19685015
[Journal Article] Mechanism-Based Probing, Characterization, and Inhibitor Design of Glycosidases and Glycosyltransferases2009
- Author(s)
  比能洋、西村紳一郎
- Journal Title
  
  Current topics in medicinal chemistry 9
  
  Pages: 106-116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19685015
[Journal Article] One-pot synthesis of cyclic antifreeze glycopeptides2009
- Author(s)
  八須匡和、比能洋、高道学、津田栄、越田周平、西村紳一郎
- Journal Title
  
  Chemical Communications
  
  Pages: 1641-1643
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19685015
[Journal Article] An Efficient Strategy for the Explortion of Specific Inhibitors of Sialyltransferases2009
- Author(s)
  Kensaku Hosoguchi, Takahiro Maeda, Jun-ichi Furukawa, Hiroshi Hinou, Shin-Ichiro Nishimura
- Journal Title
  
  Proceeding of Molecular Imaging for Integrated Medical Therapy and Drug Development( Springer)
  
  Pages: 294-301
- Data Source
  KAKENHI-PROJECT-19685015
[Journal Article] Microwave Effect for Glycosylation Promoted by Solid Super Acid in Supercritical Carbon Dioxide2009
- Author(s)
  Hiroshi Hinou, Naohiro Saito, Masato Ogawa, Takahiko Maeda, Shin-Ichiro Nishimura
- Journal Title
  
  International Journal of Molecular Science 10
  
  Pages: 5285-5295
- NAID
  120001788346
- Data Source
  KAKENHI-PROJECT-19685015
[Journal Article] A new glycosylation method part 3 : study of microwave effects at low temperatures to control, reaction pathways and reduce byproducts2008
- Author(s)
  清水弘樹、吉村弥生、比能洋、西村紳一郎
- Journal Title
  
  Tetrahedron 64
  
  Pages: 10091-10096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19685015
[Journal Article] A new glycosylation method part 3: study of microwave effects at low temperatures to control reaction pathways and reduce byproducts2008
- Author(s)
  Hiroki Shimizu, Yayoi Yoshimura, Hiroshi Hinou, Shin-Ichiro Nishimura
- Journal Title
  
  Tetrahedron 64
  
  Pages: 10091-10096
- Data Source
  KAKENHI-PROJECT-19685015
[Journal Article] One-pot solid phase glycoblotting and probing by trans-oximization for high-throughput glycomics and glycoproteomics2007
- Author(s)
  Hideyuki Shimamoka, Hiromitsu Kuramoto, Jun-ichi Furukawa, Yoshiaki Miura, Masaki Kurogochi, Yoko Kita, Hiroshi Hinou, Yasuro Shinohara, Shin-Ichiro Nishimura
- Journal Title
  
  Chemistry-A Europian Journal 13
  
  Pages: 1664-1673
- Data Source
  KAKENHI-PROJECT-19685015
[Journal Article] Structural analysis of O-glycopeptides employing negative- and positive-ion MSn spectra obtained by collision-induced and electron-capture dissociations in linear ion trap time-of-flight mass spectrometry2007
- Author(s)
  Kisaburo Deguchi, Hiroki Ito, Takashi Baba, Atsushi Hirabayashi, Hiroaki Nakagawa, Masataka Fumoto, Hiroshi Hinou, Shin-Ichiro Nishimura
- Journal Title
  
  Rapid Commun. Mass Spectrom. 21
  
  Pages: 691-698
- Data Source
  KAKENHI-PROJECT-19685015
[Journal Article] Highly efficient synthesis of versatile proteoglycan core structures from 1, 6-anhydro- β-lactose as a key starting material2007
- Author(s)
  Ken Shimawaki, Yoshinori Fujisawa, Fumihiro Sato, Naoki Fujitani, Masaki Kurogochi, Hiroko Hoshi, Hiroshi Hinou, Shin-Ichiro Nishimura
- Journal Title
  
  Angew. Chem. Int. Ed. 46
  
  Pages: 3074-3079
- Data Source
  KAKENHI-PROJECT-19685015
[Journal Article] Construction and structural characterization of versatile lactosaminoglycan-related compound library for the synthesis of complex glycopeptides and sphingoglycolipids2006
- Author(s)
  Naruchi K., Hamamoto T., Kurogochi M., Hinou H., Shimizu H., Matsushita T., Fujitani N., Kondo H., Nishimura S.-I.
- Journal Title
  
  J. Org. Chem. 71
  
  Pages: 9609-9621
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17205015
[Journal Article] Mechanism-Based Inhibitors to Probe Transitional States of Glycoside Hydrolases2006
- Author(s)
  Hinou H., Kurogochi M., Nishimura S.-I.
- Journal Title
  
  Methods in Enzymology (Academic Press) 415
  
  Pages: 202-212
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17205015
[Journal Article] Mechanism-based Probing, Characterization, and Inhibitor Design of Glycosidases and Glycosyltransferases
- Author(s)
  Hiroshi Hinou, Hirokazu Kai, Shin-Ichiro Nishimura
- Journal Title
  
  Methods in Molecular Biology (in press)
- Data Source
  KAKENHI-PROJECT-19685015
[Patent] 未修飾シアリル化複合糖質および糖ペプチドのリフレクトロンモードＭＡＬＤＩ－ＴＯＦおよびＴＯＦ／ＴＯＦ質量分析のためのマトリックス組成物2020
- Inventor(s)
  比能　洋
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-17K05920
[Patent] 未修飾シアリル化複合糖質および糖ペプチドのリフレクトロンモードＭＡＬＤＩ－ＴＯＦおよびＴＯＦ／ＴＯＦ質量分析のためのアニリン誘導体／ＤＨＢ／アルカリ金属マトリックス組成物2019
- Inventor(s)
  比能　洋
- Industrial Property Rights Holder
  比能　洋
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-011457
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-17K05920
[Patent] 特許権2007
- Inventor(s)
  西村, 紳一郎・比能, 洋
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Number
  2007-158635
- Filing Date
  2007-06-15
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17205015
[Patent] シアリダーゼ阻害剤2007
- Inventor(s)
  西村紳一郎、比能洋
- Industrial Property Rights Holder
  北海道大学
- Filing Date
  2007-05-12
- Data Source
  KAKENHI-PROJECT-19685015
[Patent] シアリダーゼ阻害剤2007
- Inventor(s)
  比能洋、西村紳一郎
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Number
  2007-133705
- Filing Date
  2007-05-21
- Data Source
  KAKENHI-PROJECT-19685015
[Patent] シアリダーゼ阻害剤2007
- Inventor(s)
  西村紳一郎、比能洋
- Industrial Property Rights Holder
  北海道大学
- Filing Date
  2007-06-15
- Data Source
  KAKENHI-PROJECT-19685015
[Patent] 特許権2007
- Inventor(s)
  西村, 紳一郎・比能, 洋
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Number
  2007-133706
- Filing Date
  2007-05-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17205015
[Patent] シアリダーゼ阻害剤2007
- Inventor(s)
  比能洋、西村紳一郎
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Number
  2007-158635
- Filing Date
  2007-06-15
- Data Source
  KAKENHI-PROJECT-19685015
[Presentation] Chemical Glycobiology (Starting from Glycoconjugate Syntheses)2020
- Author(s)
  Hiroshi Hinou
- Organizer
  107th Indian Science Congress, Bagalore
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K05920
[Presentation] Novel matrix system for reflectron mode MALDI-TOF and TOF/TOF MS analysis of unmodified sialylated oligosaccharides and glycopeptides2019
- Author(s)
  Hinou Hiroshi
- Organizer
  Japanese-American Symposium on Applied & Translational Glycosciences、ACS Fall 2019 National
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H00918
[Presentation] Novel matrix system for reflectron mode MALDI-TOF and TOF/TOF MS analysis of unmodified sialylated oligosaccharides and glycopeptides2019
- Author(s)
  Hiroshi Hinou
- Organizer
  Japanese-American Symposium on Applied & Translational Glycosciences, ACS Fall 2019 National Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K05920
[Presentation] シアリル化糖鎖・複合糖質の直接MALDI-TOFMS解析法2019
- Author(s)
  比能　洋
- Organizer
  第38回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-17K05920
[Presentation] Microarray and NMR Study of Core M1 Glycan Modified α-Dystroglycan Fragments2018
- Author(s)
  Hiroshi Hinou
- Organizer
  International Congress on Pure and Applied Chemistry 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K05920
[Presentation] Glycoblotting型マイクロアレイによる合成糖ペプチドの相互作用解析2016
- Author(s)
  比能洋
- Organizer
  第65回高分子討論会
- Place of Presentation
  神奈川大学（神奈川県横浜市）
- Year and Date
  2016-09-15
- Data Source
  KAKENHI-PROJECT-25220206
[Presentation] 糖ペプチド合成システムの開発と展開2016
- Author(s)
  比能洋
- Organizer
  ペプチド研究所研究講演会
- Place of Presentation
  ペプチド研究所（大阪府茨木市）
- Year and Date
  2016-07-28
- Data Source
  KAKENHI-PROJECT-25220206
[Presentation] 糖質の化学生物学2016
- Author(s)
  比能洋
- Organizer
  第1回国際的キャリア展望に向けた生命科学研究者による講演会
- Place of Presentation
  岡山大学（岡山県・岡山市）
- Year and Date
  2016-01-21
- Invited
- Data Source
  KAKENHI-PROJECT-25220206
[Presentation] 糖ペプチド迅速合成法の開発と展開2015
- Author(s)
  比能洋
- Organizer
  第47回若手ペプチド夏の勉強会
- Place of Presentation
  アスティかたおか（長野県・塩尻市）
- Year and Date
  2015-08-10
- Invited
- Data Source
  KAKENHI-PROJECT-25220206
[Presentation] Synthesis and Application of Bicyclic Carbohydrates2014
- Author(s)
  Hiroshi Hinou
- Organizer
  International Symposium on Chemical Biology-Drug Discovery
- Place of Presentation
  Mysore Universitu, Mysore, India
- Year and Date
  2014-01-10
- Data Source
  KAKENHI-PROJECT-23350074
[Presentation] Modified Mechanism-based Inhibitor for Neuraminidases2013
- Author(s)
  Hiroshi Hinou, Hirokazu Kai, Shin-Ichiro Nishimura
- Organizer
  The 11 th International Symposium for Future Drug Discovery & Medical Care
- Place of Presentation
  Sapporo
- Year and Date
  2013-08-02
- Data Source
  KAKENHI-PROJECT-23350074
[Presentation] New Strategy for Peptide Cyclization H-bonding effect of fluorinated alcohol2013
- Author(s)
  Hiroshi Hinou
- Organizer
  Special Seminar at Chemistry Department of Wane State University
- Place of Presentation
  Detroit, USA
- Year and Date
  2013-09-06
- Data Source
  KAKENHI-PROJECT-23350074
[Presentation] Highly Efficient Synthesis of Hyperbranched N-glycans from Locust Bean Gum2013
- Author(s)
  H. V. Ravi Kumar, Kentaro Naruchi, Risho Miyoshi, Hiroshi Hinou, Risho Miyoshi, Shin-Ichiro Nishimura
- Organizer
  246th American Chemical Society Meeting & Exposition
- Place of Presentation
  Indianapolis (IN), USA
- Year and Date
  2013-09-08
- Data Source
  KAKENHI-PROJECT-23350074
[Presentation] ヒトエリスロボエチン受容体のC-マンノシルトリプトファン含有当ペプチド領域の合成と配座解析2012
- Author(s)
  阿部悠弥、比能洋、松下隆彦、Fayna G.Martin、早川瞬、古川貴之、藤谷直樹、成地健太郎、西村紳一郎
- Organizer
  第46回高分子学会北海道支部研究発表会
- Place of Presentation
  北海道大学(札幌市)
- Year and Date
  2012-01-31
- Data Source
  KAKENHI-PROJECT-23350074
[Presentation] Modified Mechanism-based Inhibitor for Neuraminidases2012
- Author(s)
  Hiroshi Hinou, Hirokazu Kai, Shin-Ichiro Nishimura
- Organizer
  The 10th International Symposium for Future Drug Discovery & Medical Care
- Place of Presentation
  Sapporo
- Year and Date
  2012-10-03
- Data Source
  KAKENHI-PROJECT-23350074
[Presentation] ^1C_4配座を有する新奇グルクロン酸糖供与体に関する研究2012
- Author(s)
  古川貴之、比能洋、西村紳一郎
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学(札幌市)
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-23350074
[Presentation] 糖誘導体・糖ペプチドの環化と機能制御2012
- Author(s)
  比能洋
- Organizer
  日本化学会生体機能関連化学部会第27回若手フォーラム
- Place of Presentation
  札幌
- Year and Date
  2012-09-05
- Data Source
  KAKENHI-PROJECT-23350074
[Presentation] グライコブロッティング法を用いた異なる種類のヒアルロン酸分解酵素生成ヒアルロン酸断片の同定2012
- Author(s)
  荒井みさき、古川貴之、ガルシアファイナ、比能洋、天野麻穂、西村紳一郎
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学(札幌市)
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-23350074
[Presentation] H-bonding cyclization of peptide backbone of anti-freeze glycopeptide in fluorinated alcohols2012
- Author(s)
  Hiroshi Hinou, Kei Hyugaji, Fayna Garcia-Martin, Shin-Ichiro Nishimura, Fernando Albericio
- Organizer
  XXVI International Carbohydrate Symposium (ICS XXVI)
- Place of Presentation
  Madrid, Spain
- Data Source
  KAKENHI-PROJECT-23350074
[Presentation] Solid-Phase Synthesis and Structural Study of Glycopeptide Containing C-Mannosyltriptophan in Human Erythropoietin Receptor2012
- Author(s)
  Hiroshi Hinou
- Organizer
  International Glycomics Symposium -Increasing the Impact of Glycoscience through New Tools and Technologies-
- Place of Presentation
  Auditorium Tech Park Miramon (San Sebastian, Spain)
- Data Source
  KAKENHI-PROJECT-23350074
[Presentation] 糖誘導体・糖ペプチドの環化と機能制御2012
- Author(s)
  比能　洋
- Organizer
  日本化学会生体機能関連化学部会第２７回若手フォーラム
- Place of Presentation
  北海道大学（札幌市）
- Invited
- Data Source
  KAKENHI-PROJECT-23350074
[Presentation] 機能性デンドリマーを用いた糖ペプチドの酵素化学的合成法2012
- Author(s)
  半田誠治、松下隆彦、比能洋、西村紳一郎
- Organizer
  第46回高分子学会北海道支部研究発表会
- Place of Presentation
  北海道大学(札幌市)
- Year and Date
  2012-01-31
- Data Source
  KAKENHI-PROJECT-23350074
[Presentation] Macrocyclic Mechanism-based Inhibitor for Neuraminidases2012
- Author(s)
  Hiroshi Hinou, Hirokazu Kai, Shin-Ichiro Nishimura
- Organizer
  XXVI International Carbohydrate Symposium (ICS XXVI)
- Place of Presentation
  Madrid, Spain
- Data Source
  KAKENHI-PROJECT-23350074
[Presentation] Solid-Phase Synthesis and Structural Study of Glycopeptide Containing C-Mannosyltriptophan in Human Erythropoietin Receptor2012
- Author(s)
  Hiroshi Hinou, Yuya abe, and Shin-Ichiro Nishimura
- Organizer
  International Glycomics Symposium -Increasing the Impact of Glycoscience through New Tools and Technologies-
- Place of Presentation
  San Sebastian, Spain
- Year and Date
  2012-07-19
- Data Source
  KAKENHI-PROJECT-23350074
[Presentation] ムチン型糖ペプチドにおけるTTXモチーフのNMR構造解析2012
- Author(s)
  早川瞬、松下隆彦、比能洋、西村紳一郎
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学(札幌市)
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-23350074
[Presentation] Macrocyclic Mechanism-based Inhibitor for Neuraminidases2012
- Author(s)
  Hiroshi Hinou
- Organizer
  XXVI International Carbohydrate Symposium (ICS XXVI)
- Place of Presentation
  El Hotel Melia Castilla (Madrid, Spain)
- Data Source
  KAKENHI-PROJECT-23350074
[Presentation] H-bonding cyclization of peptide backbone of anti-freeze glycopeptide in fluorinated alcohols2012
- Author(s)
  Hiroshi Hinou
- Organizer
  XXVI International Carbohydrate Symposium (ICS XXVI)
- Place of Presentation
  El Hotel Melia Castilla (Madrid, Spain)
- Data Source
  KAKENHI-PROJECT-23350074
[Presentation] Modified Mechanism-based Inhibitor for Neuraminidases2012
- Author(s)
  Hiroshi Hinou
- Organizer
  The 10th International Symposium for Future Drug Discovery & Medical Care
- Place of Presentation
  北海道大学（札幌市）
- Data Source
  KAKENHI-PROJECT-23350074
[Presentation] 不凍糖ペプチドの効率的環化法の開発と配座解析2012
- Author(s)
  日向寺慧、比能洋、F.Garcia-Martin、松下隆彦、成地健太郎、西村紳一郎
- Organizer
  第46回高分子学会北海道支部研究発表会
- Place of Presentation
  北海道大学(札幌市)
- Year and Date
  2012-01-31
- Data Source
  KAKENHI-PROJECT-23350074
[Presentation] 糖鎖補足反応を用いた新規糖脂質ライブラリの構築と溶液中における構造解析2012
- Author(s)
  石田純也、比能洋、西村紳一郎
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学(札幌市)
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-23350074
[Presentation] 糖鎖補足反応を用いた新規糖脂質ライブラリの構築と溶液中における構造解析2011
- Author(s)
  石田純也、比能洋、西村紳一郎
- Organizer
  2011年度北海道高分子若手研究会
- Place of Presentation
  洞爺サンパレス(北海道)
- Year and Date
  2011-08-26
- Data Source
  KAKENHI-PROJECT-23350074
[Presentation] ケイ素保護基を利用した糖ペプチドの迅速固相合成法2011
- Author(s)
  藤井宏圭、松下隆彦、比能洋、西村紳一郎
- Organizer
  2011年度北海道高分子若手研究会
- Place of Presentation
  洞爺サンパレス(北海道)
- Year and Date
  2011-08-26
- Data Source
  KAKENHI-PROJECT-23350074
[Presentation] ヒトErythropoietin Receptor由来C-マンノシルトリプトファン含有糖ペプチドの合成および構造解析2011
- Author(s)
  阿部悠弥、比能洋、成地健太郎、西村紳一郎
- Organizer
  2011年度北海道高分子若手研究会
- Place of Presentation
  洞爺サンパレス(北海道)
- Year and Date
  2011-08-26
- Data Source
  KAKENHI-PROJECT-23350074
[Presentation] 配座反転糖供与体を利用したグリコサミノグリカン二糖の合成研究2011
- Author(s)
  古川貴之、比能洋、西村紳一郎
- Organizer
  2011年度北海道高分子若手研究会
- Place of Presentation
  洞爺サンパレス(北海道)
- Year and Date
  2011-08-26
- Data Source
  KAKENHI-PROJECT-23350074
[Presentation] 機能性デンドリマーを用いた糖ペプチドの酵素化学的合成法2011
- Author(s)
  半田誠治、松下隆彦、比能洋、西村紳一郎
- Organizer
  2011年度北海道高分子若手研究会
- Place of Presentation
  洞爺サンパレス(北海道)
- Year and Date
  2011-08-26
- Data Source
  KAKENHI-PROJECT-23350074
[Presentation] 環状不凍糖タンパク質の効率的合成法の開発2011
- Author(s)
  日向寺慧、比能洋、F.Garcia-Martin、西村紳一郎
- Organizer
  2011年度北海道高分子若手研究会
- Place of Presentation
  洞爺サンパレス(北海道)
- Year and Date
  2011-08-26
- Data Source
  KAKENHI-PROJECT-23350074
[Presentation] 糖鎖蛍光ナノ微粒子の合成および生きた動物のイメージングへの応用2011
- Author(s)
  大柳達也、長堀紀子、嶋脇健、比能洋、山下匡、佐々木章、神隆、岩永敏彦、金城政孝、西村紳一郎
- Organizer
  2011年度北海道高分子若手研究会
- Place of Presentation
  洞爺サンパレス(北海道)
- Year and Date
  2011-08-26
- Data Source
  KAKENHI-PROJECT-23350074
[Presentation] Novel Strategy for Neuraminidase Inhibitors Using Mechanism-based probe2010
- Author(s)
  Hiroshi Hinou, Risho Miyoshi, Yasuaki Takasu, Hirokazu Kai, Masaki Kurogochi, Xiao-Dong Gao, Shin-Ichiro Nishimura
- Organizer
  American Chemical Society Spring 2010 National Meeting & Exposition
- Place of Presentation
  San Francisco, U.S.A
- Year and Date
  2010-03-24
- Data Source
  KAKENHI-PROJECT-19685015
[Presentation] Development of Novel Sialidase Suicide Substrate2010
- Author(s)
  甲斐宏一、比能洋、西村紳一郎
- Organizer
  日本化学会・第90春季年会
- Place of Presentation
  近畿大学・大阪
- Data Source
  KAKENHI-PROJECT-19685015
[Presentation] Novel Strategy for Neuraminidase Inhibitors Using Mechanism-based probe2010
- Author(s)
  Hiroshi Hinou, Risho Miyoshi, Yasuaki Takasu, Hirokazu Kai, Masaki Kurogochi, Xiao-Dong Gao, Shin-Ichiro Nishimura
- Organizer
  American Chemical Society Spring 2010 National Meeting & Exposition
- Place of Presentation
  San Francisco (CA), USA
- Data Source
  KAKENHI-PROJECT-19685015
[Presentation] Research on the development of novel structure-based sialidase inhibitors2009
- Author(s)
  佐藤公法、比能洋、西村紳一郎
- Organizer
  The 6^<th> Symposium for Future Drug Discovery and Medical Care
- Place of Presentation
  北海道大学(札幌)
- Year and Date
  2009-03-13
- Data Source
  KAKENHI-PROJECT-19685015
[Presentation] 新規骨格をベースとしたシアリダーゼ阻害剤の開発研究2009
- Author(s)
  佐藤公法、比能洋、高須康明、黒河内政樹、西村紳一郎
- Organizer
  日本化学会第89春季年会
- Place of Presentation
  日本大学理工学部(船橋)
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-19685015
[Presentation] Mechanism-based fluorescent labeling of BSA using suicide substrate2009
- Author(s)
  Takayuki Hurukawa, Hiroshi Hinou, Fei Feng, Shin-Ichiro Nishimura
- Organizer
  The 6th Symposium for Future Drug Discovery and Medical Care
- Place of Presentation
  Sapporo(Poster)
- Year and Date
  2009-03-13
- Data Source
  KAKENHI-PROJECT-19685015
[Presentation] 自殺基質型酵素プローブを用いたVibrio cholerae neuraminidase阻害剤の開発2009
- Author(s)
  比能洋、三好利尚、高須康明、甲斐宏一、西村紳一郎
- Organizer
  GFRGシンポジウム
- Place of Presentation
  札幌(ポスター)
- Year and Date
  2009-08-25
- Data Source
  KAKENHI-PROJECT-19685015
[Presentation] Research on the development of novel structure-based sialidase inhibitors2009
- Author(s)
  Kiminori Sato, Hiroshi Hinou, Shin-Ichiro Nishimura
- Organizer
  The 6th Symposium for Future Drug Discovery and Medical Care
- Place of Presentation
  Sapporo(Poster)
- Year and Date
  2009-03-13
- Data Source
  KAKENHI-PROJECT-19685015
[Presentation] Design and Synthesis, and Evaluation of Sialidase Inhibitors Based on Enzymatic Dynamism2009
- Author(s)
  Hirokazu Kai, Yasuaki Takasu, Rishou Miyoshi, Masaki Kurogochi, Hiroshi Hinou, Shin-Ichiro Nishimura
- Organizer
  The 6th Symposium for Future Drug Discovery and Medical Care
- Place of Presentation
  Sapporo(Poster)
- Year and Date
  2009-03-13
- Data Source
  KAKENHI-PROJECT-19685015
[Presentation] An efficient strategy for the exploration of specific inhibitors of sialyltransferases2009
- Author(s)
  Kensaku Hosoguchi, Takahiro Maeda, Jun-ichi Furukawa, Hiroshi Hinou, Shin-ichiro Nishimura
- Organizer
  The 6th Symposium for Future Drug Discovery and Medical Care
- Place of Presentation
  Sapporo(Poster)
- Year and Date
  2009-03-13
- Data Source
  KAKENHI-PROJECT-19685015
[Presentation] ppGalNAcT阻害剤に関する研究2009
- Author(s)
  阿部皓基, 比能洋, 古川潤一, 前田哲宏, 細口健作, 西村紳一郎
- Organizer
  日本化学会第89春季年会
- Place of Presentation
  船橋
- Data Source
  KAKENHI-PROJECT-19685015
[Presentation] 新規自殺基質を用いた蛋白質のラベル化2009
- Author(s)
  古川貴之、比能洋、馮飛、西村紳一郎
- Organizer
  日本化学会第89春季年会
- Place of Presentation
  船橋(ポスター)
- Data Source
  KAKENHI-PROJECT-19685015
[Presentation] Mechanism-based fluorescent labeling of BSA using suicide substrate2009
- Author(s)
  古川貴之、比能洋、馮飛、西村紳一郎
- Organizer
  The 6^<th> for Future Drug Discovery and Medical Care
- Place of Presentation
  北海道大学(札幌)
- Year and Date
  2009-03-13
- Data Source
  KAKENHI-PROJECT-19685015
[Presentation] ppGaINAcT阻害剤に関する研究2009
- Author(s)
  阿部皓基, 比能洋, 古川潤一, 前田哲宏, 細口健作, 西村紳一郎
- Organizer
  日本化学会第89春季年会
- Place of Presentation
  日本大学理工学部(船橋)
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-19685015
[Presentation] 新規自殺基質を用いた蛋白質のラベル化2009
- Author(s)
  古川貴之、比能洋、馮飛、西村紳一郎
- Organizer
  日本化学会第89春季年会
- Place of Presentation
  日本大学理工学部(船橋)
- Year and Date
  2009-03-29
- Data Source
  KAKENHI-PROJECT-19685015
[Presentation] 新規骨格をベースとしたシアリダーゼ阻害剤の開発研究2009
- Author(s)
  佐藤公法、比能洋、高須康明、黒河内政樹、西村紳一郎
- Organizer
  日本化学会第89春季年会
- Place of Presentation
  船橋(ポスター)
- Data Source
  KAKENHI-PROJECT-19685015
[Presentation] Novel inhibitor development for fucosyltransferases using simple donor analog as a scaffold2009
- Author(s)
  Takahiro Maeda, Jun-ichi Furukawa, Kenji Takaya, Hiroshi Hinou, Shin-Ichiro Nishimura
- Organizer
  The 6th Symposium for Future Drug Discovery and Medical Care
- Place of Presentation
  Sapporo(Poster)
- Year and Date
  2009-03-13
- Data Source
  KAKENHI-PROJECT-19685015
[Presentation] Design and Synthesis, and Evaluation of Sialidase Inhibitors Based on Enzymatic Dynamism2009
- Author(s)
  甲斐宏一, 高須康明, 三好利尚, 黒河内政樹, 比能洋, 西村紳一郎
- Organizer
  The 6^<th> Symposium for Future Drug Discovery and Medical Care
- Place of Presentation
  北海道大学(札幌)
- Year and Date
  2009-03-13
- Data Source
  KAKENHI-PROJECT-19685015
[Presentation] フォーカスドライブラリーを用いた特異的シアル酸転移酵素阻害剤の探索2008
- Author(s)
  細口健作、古川潤一、前田哲宏、比能洋、西村紳一郎
- Organizer
  第42回高分子学会北海道支部研究発表会
- Place of Presentation
  札幌
- Year and Date
  2008-01-29
- Data Source
  KAKENHI-PROJECT-19685015
[Presentation] Mechanism-based Strutegy Toward Novel Inhibitor of Sialidases2008
- Author(s)
  Hiroshi Hinou, Yasuaki Takasu, Kiminori Sato, Hirokazu Kai, Masaki Kurogochi, Nobuaki Miura, Taku Nakahara, Xiao-Dong Gao, Shin-Icho Nishimura
- Organizer
  XXIV International Carbohydrate Symposium
- Place of Presentation
  Oslo, Norway(Poster)
- Data Source
  KAKENHI-PROJECT-19685015
[Presentation] シアリダーゼ自殺基質におけるアグリコンフォーカスドライブラリーの作成と評価2008
- Author(s)
  甲斐宏一、比能洋、西村紳一郎
- Organizer
  第42回高分子学会北海道支部研究発表会
- Place of Presentation
  札幌(ポスター)
- Year and Date
  2008-01-29
- Data Source
  KAKENHI-PROJECT-19685015
[Presentation] 酵素の動的構造に着目したシアリダーゼ阻害剤の開発研究2008
- Author(s)
  高須康明、黒河内政樹、比能洋、西村紳一郎
- Organizer
  高分子学会第42回北海道支部研究発表会
- Place of Presentation
  札幌
- Year and Date
  2008-01-29
- Data Source
  KAKENHI-PROJECT-19685015
[Presentation] シアリダーゼ自殺基質におけるアグリコンフォーカストライブラリーの作製と評価2008
- Author(s)
  甲斐宏一、比能洋、西村紳一郎
- Organizer
  高分子学会第42回北海道支部研究発表会
- Place of Presentation
  札幌
- Year and Date
  2008-01-29
- Data Source
  KAKENHI-PROJECT-19685015
[Presentation] An Efficient Strategy for the Exploration of Specific Inhibitors of Sialyltransferases2007
- Author(s)
  Kensaku Hosoguchi, Junichi Furukawa, Hirohsi Hinou, Shin-Ichiro Nishimura
- Organizer
  Annual Meeting of the Society for Glycobiology
- Place of Presentation
  Boston, USA(Poster)
- Data Source
  KAKENHI-PROJECT-19685015
[Presentation] Design and synthesis and evaluation of sialidase inhibitors based on enzymatic dynamism2007
- Author(s)
  Yasuaki Takasu, Masaki Kurogochi, Hiroshi Hinou, Shin-Ichiro Nishimura
- Organizer
  Annual Meeting of the Society for Glycobiology
- Place of Presentation
  Boston (USA)
- Year and Date
  2007-11-13
- Data Source
  KAKENHI-PROJECT-19685015
[Presentation] Design and synthesis and evaluation of sialidase inhibitors based on enzymatic dynamism2007
- Author(s)
  Yasuaki Takasu, Masaki Kurogochi, Hiroshi Hinou, Shin-Ichiro Nishimura
- Organizer
  Annual Meeting of the Society for Glycobiology
- Place of Presentation
  Boston, USA(Poster)
- Data Source
  KAKENHI-PROJECT-19685015
[Presentation] Highly Efficient Synthesis of Hyperbranched N-glycans from Locust Bean Gum
- Author(s)
  H. V. Ravi Kumar, Kentaro Naruchi, Risho Miyoshi, Hiroshi Hinou, Risho Miyoshi, Shin-Ichiro Nishimura
- Organizer
  246th American Chemical Society Meeting & Exposition
- Place of Presentation
  Indianapolis Conference Center (USA)
- Data Source
  KAKENHI-PROJECT-23350074
[Presentation] Synthesis and Application of Bicyclic Carbohydrates
- Author(s)
  Hiroshi Hinou
- Organizer
  International Symposium on Chemical Biology-Drug Discovery
- Place of Presentation
  Mysore University (India)
- Invited
- Data Source
  KAKENHI-PROJECT-23350074
[Presentation] New Strategy for Peptide Cyclization H-bonding effect of fluorinated alcohol
- Author(s)
  Hiroshi Hinou
- Organizer
  Special Seminar at Chemistry Department of Wane State University
- Place of Presentation
  Wayne State University (USA)
- Invited
- Data Source
  KAKENHI-PROJECT-23350074

1. Nishimura Shin-Ichiro (00183898)

# of Collaborated Projects: 3 results

# of Collaborated Products: 24 results
2. KIMURA Katsuki (10292054)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. AIZAWA Tomoyasu (40333596)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. NAGAHORI Noriko (90372268)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 能祖一裕 (10314668)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 大山力 (80282135)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 神山俊哉 (80322816)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 天野麻穂 (80365808)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. 篠原康郎 (20374192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 田中良和 (20374225)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 尾瀬農之 (80380525)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 戸田雅子 (10828429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 佐分利亘 (00598089)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 新谷尚弘 (70374973)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. ファイナガルシア・マーティン

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
16. 黒岩繁樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 秀島翔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 米山徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 津田栄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HINOU Hiroshi 比能 洋

HINOU HIROSHI 比能 洋

Research Projects

Research Products

Co-Researchers

Antibodies targeting dynamic epitopes generated by posttranslational protein glycosylationOngoing

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D-マンノ－ス骨格を持つ糖鎖による免疫・炎症反応制御とその分子基盤の解析Ongoing

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Multidimensional investigation of Glycopeptide-lectin interactionPrincipal Investigator

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Exploration of Novel Markers on Cancer and Development of a Technology for the Diagnosis Utilized by Comprehensive Glycomics

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Control of membrane fouling based on structures of polysaccharides revealed by application of glyco-blotting

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Study for rapid synthesis and mechanism elucidation of cyclic antifreeze glycopeptidePrincipal Investigator

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Development of novel compound of function selective labeling reagent for proteins and its systematic usePrincipal Investigator

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Function search of glycoconjugates by selective laser desorption ionization mass spectronmeter using metal nanoparticle

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[Book] Methods in Enzymology2006

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[Book] Methods in Enzymology2006

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[Journal Article] A straightforward approach to antibodies recognising cancer specific glycopeptidic neoepitopes2020

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[Journal Article] Synthesis, conformational analysis and in vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment2020

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[Journal Article] Impaired O-Glycosylation at Consecutive Threonine TTX Motifs in Mucins Generates Conformationally Restricted Cancer Neoepitopes2020

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[Journal Article] Synthetic glycopeptides reveal specific binding pattern and conformational change at O-mannosylated position of α-dystroglycan by POMGnT1 catalyzed GlcNAc modification2019

Author(s)

HINOU Hiroshi 比能洋

HINOU HIROSHI 比能洋