ISHIYAMA Haruaki 石山玄明

… Alternative Names

石山玄明イシヤマハルアキ

Less

Researcher Number	70333622
Other IDs
External Links
Affiliation (Current)	2025: 奥羽大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2014: 北海道大学, 大学院薬学研究院, 助教 2007 – 2010: Hokkaido University, 大学院・薬学研究院, 助教 2007: Hokkaido University, Graduate School of Pharmaceutical Sciences, Assistant Professor 2006: 北海道大学, 大学院薬学研究科, 助手 2006: 北海道大学, 大学院薬学研究院, 助手 2002 – 2005: 北海道大学, 大学院・薬学研究科, 助手
Review Section/Research Field	Principal Investigator Chemical pharmacy / Chemical pharmacy Except Principal Investigator Living organism molecular science / Biological Sciences / Natural medicines / Chemical pharmacy / Science and Engineering
Keywords	Principal Investigator 絶対立体配置 / マクロリド / Amphidinium sp. / 全合成 / ハイブリッド化合物 / アデノシン受容体 / カフェイン / 天然物化学 / 生薬 / アンフィジノリドN … More / Amphidinium sp / 渦鞭毛藻 / アンフィジノリドA / Pyrinodemin A / 海綿動物 / Amphimedon sp. / Pyrinodemien A … More Except Principal Investigator 分子標的 / 天然薬物 / リード化合物 / 天然資源 / チューブリン / アクチン / バイオプローブ / 医薬リード / がん治療 / がん分子標的 / Malaysia / crude drug / plant / antitumor / 抗マラリア / マレーシア / 植物 / 癌 / Read Compound / Natural Resource / Molecular Target / Tubulin / Actin / Nocardia sp. / 病原性放線菌 / 免疫抑制剤 / 抗腫瘍剤 / System L / アミノ酸輸送体 / Nocardia brasiliensis / 放線菌 / ブラシリカルジンA / 海洋生物 / 天然物ライブラリー / 海洋天然物 / 機能性天然分子 Less

Development of new antitumor agents and immunosuppressive agents using brasilicardin-A as a lead compound
- Principal Investigator
  
  KOBAYASHI Jun'ichi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Natural medicines
- Research Institution
  Hokkaido University
Research and development of bioactive marine natural products
- Principal Investigator
  
  KOBAYASHI Jun'ichi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Hokkaido University
Synthesis of eudistomin D analogues and its effects on adenosine receptorsPrincipal Investigator
- Principal Investigator
  
  ISHIYAMA Haruaki
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Hokkaido University
創薬素材としての細胞骨格系機能性分子の探索
- Principal Investigator
  
  小林淳一
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Hokkaido University
渦鞭毛藻由来の細胞毒性マクロリド・アンフィジノリドNの立体化学の解明Principal Investigator
- Principal Investigator
  
  石山玄明
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Hokkaido University
がん分子標的に特異的に作用する天然薬物の開発
- Principal Investigator
  
  小林淳一
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Research for Antitumor Crude Drug from Malaysian Unutilized Plant Resorces
- Principal Investigator
  
  MORITA Hiroshi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Hoshi University
がん分子標的に特異的に作用する天然薬物の開発
- Principal Investigator
  
  KOBAYASHI Jun'ichi
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
海洋産新規抗腫瘍性マクロリド・アンフィジノリドAの立体化学の解明Principal Investigator
- Principal Investigator
  
  石山玄明
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Hokkaido University
Research and development of bioactive natural products targeting cytoskeleton.
- Principal Investigator
  
  KOBAYASHI Jun'ichi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  HOKKAIDO UNIVERSITY
特異な環構造を有するアルカロイドpyrinodemin Aの絶対立体化学の解明Principal Investigator
- Principal Investigator
  
  石山玄明
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Hokkaido University

All 2015 2014 2013 2010 2009 2008 2007 2006 2005

All Journal Article Presentation

[Journal Article] Amphidinin G, a putative precursor of amphidinin A from marine dinoflagellate Amphidinium sp.2015
- Author(s)
  Kubota, T.; Iwai, T.; Ishiyama, H.; Sakai, K.; Gonoi, T.; Kobayashi, J.
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 56 Issue: 8 Pages: 990-993
- DOI
  10.1016/j.tetlet.2015.01.058
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460115, KAKENHI-PROJECT-25670043
[Journal Article] Synthesis of the C1-C7 and C8-C18 segments of ent-amphidinin A2014
- Author(s)
  Ishiyama, H.; Hangyou, M.; Nakatsu, A.; Mori, Y.; Kobayashi, J.
- Journal Title
  
  Heterocycles
  
  Volume: 90 Issue: 2 Pages: 1254-1273
- DOI
  10.3987/com-14-s(k)107
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25670043
[Journal Article] Eudistomidin G, a new b-carboline alkaloid from the Okinawan marine tunicate Eudistoma glaucus and structure revision of eudistomidin B2010
- Author(s)
  Takahashi, Y.; Ishiyama, H.; Kubota, T.; Kobayashi, J.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 20 Issue: 14 Pages: 4100-4103
- DOI
  10.1016/j.bmcl.2010.05.071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390001
[Journal Article] Total synthesis of amphidinolactone A and its absolute configuration2009
- Author(s)
  Hangyou, M.; Ishiyama, H.; Takahashi, Y.; Kubota, T.; Kobayashi, J.
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 50 Issue: 13 Pages: 1475-1477
- DOI
  10.1016/j.tetlet.2009.01.065
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390001
[Journal Article] Synthesis of hybrid analogues of caffeine and eudistomin D and its affinity for adenosine receptors2009
- Author(s)
  Ishiyama, H.
- Journal Title
  
  Bioorg.Med.Chem. 13
  
  Pages: 4280-4284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790001
[Journal Article] Synthesis of hybrid analogues of caffeine and eudistomin D and its affinity for adenosine receptors2009
- Author(s)
  Ishiyama, H.
- Journal Title
  
  Bioorg.Med.Chem. 17
  
  Pages: 4280-4284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390001
[Journal Article] Synthesis of hybrid analogues of caffeine and eudistomin D and its affinity for adenosine receptors Bioorg.2009
- Author(s)
  Ishiyama, H.; Nakajima, H.; Nakata, H.; Kobayashi, J.
- Journal Title
  
  Med. Chem. 17
  
  Pages: 4280-4284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790001
[Journal Article] Total synthesis of amphidinolide Q2009
- Author(s)
  Hangyou, M.; Ishiyama, H.; Takahashi, Y.; Kobayashi, J.
- Journal Title
  
  Org. Lett.
  
  Volume: 11 Issue: 21 Pages: 5046-5049
- DOI
  10.1021/ol902026f
- NAID
  110009757779
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390001
[Journal Article] Synthesis of hybrid analogues of caffeine and eudistomin D and its affinity for adenosine receptors2009
- Author(s)
  Ishiyama, H.; Nakajima, H.; Nakata, H.; Kobayashi, J.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 17 Issue: 13 Pages: 4280-4284
- DOI
  10.1016/j.bmc.2009.05.036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390001
[Journal Article] Zamamidine C, 3,4-dihydro-6-hydroxy-10,11-epoxymanzamine A, and 3,4-dihydromanzamine J N-oxide, new manzamine alkaloids from sponge Amphimedon sp.2009
- Author(s)
  Yamada, M.; Takahashi, Y.; Kubota, T.; Fromont, J.; Ishiyama, A.; Otoguro, K.; Yamada, H.; Omura, S; Kobayashi, J.
- Journal Title
  
  Tetrahedron
  
  Volume: 65 Issue: 11 Pages: 2313-2317
- DOI
  10.1016/j.tet.2009.01.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390001
[Journal Article] Synthesis of eudistomin D analogues and its effects on adenosine receptors2008
- Author(s)
  Ishiyama, H
- Journal Title
  
  Bioorg. Med. Chem 16
  
  Pages: 3825-3830
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790001
[Journal Article] Synthesis of eudistomin D analogues and its effects on adenosine receptors Bioorg.2008
- Author(s)
  Ishiyama, H.; Ohshita, K.; Abe, T.; Nakata, H.; Kobayashi, J.
- Journal Title
  
  Med. Chem. 16
  
  Pages: 3825-3830
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790001
[Journal Article] Taxezopidines O and P, new taxoids from Taxus cuspidata2007
- Author(s)
  Ishiyama, H.
- Journal Title
  
  Heterocycles 73
  
  Pages: 341-348
- NAID
  40015763805
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18032005
[Journal Article] Asymmetric Synthesis of a Diastereomer of the Structure Proposed for Amphidinolide A and the Determination of Its Absolute Configuration2006
- Author(s)
  Ishiyama, H.
- Journal Title
  
  Tetrahedron 62(1)
  
  Pages: 166-170
- Data Source
  KAKENHI-PROJECT-16790001
[Journal Article] Asymmetric synthesis of a diastereomer of the structure proposed for amphidinolide A and the determination of Its absolute configuration2006
- Author(s)
  Ishiyama, H.
- Journal Title
  
  Tetrahedron 62(1)
  
  Pages: 166-170
- Data Source
  KAKENHI-PROJECT-18790001
[Journal Article] Tow new indole alkaloids from Aspidosperma subincanum and Geissospermum vellosii2005
- Author(s)
  Ishiyama, H.
- Journal Title
  
  Heterocycles 66(1)
  
  Pages: 651-658
- Data Source
  KAKENHI-PROJECT-16790001
[Journal Article] Halichonadins A〜D, new sesquitepenoids from a sponge Halichondria sp2005
- Author(s)
  Ishiyama, H.
- Journal Title
  
  Tetrahedron 61(5)
  
  Pages: 1101-1105
- Data Source
  KAKENHI-PROJECT-16790001
[Journal Article] Asymmetric Synthesis of Double Bond Isomers of the Structure Proposed for Pyrinodemin A and Indication of Its Structural Revision2005
- Author(s)
  Ishiyama, H.
- Journal Title
  
  Molecules 10(1)
  
  Pages: 312-316
- Data Source
  KAKENHI-PROJECT-16790001
[Presentation] アンフィジニンAの立体化学解明を目指した合成研究2013
- Author(s)
  内田貴久、中津あゆみ、森雄太、萩行正博、石山玄明、小林淳一
- Organizer
  日本生薬学会第60回年会
- Place of Presentation
  北海道当別町、北海道医療大学当別キャンパス中央講義棟
- Data Source
  KAKENHI-PROJECT-25670043
[Presentation] ケラマミンCの絶対立体配置解明のための全合成2013
- Author(s)
  石山玄明、森雄太、小林淳一
- Organizer
  日本生薬学会第60回年会
- Place of Presentation
  北海道当別町、北海道医療大学当別キャンパス中央講義棟
- Data Source
  KAKENHI-PROJECT-25670043
[Presentation] 渦鞭毛藻由来の12員環マクロリド・Amphidinolide Qの全合成2010
- Author(s)
  石山玄明(小林淳一)
- Organizer
  第52回天然有機化合物討論会
- Place of Presentation
  グランシップ静岡県コンベンションアーツセンター(静岡県)
- Year and Date
  2010-09-29
- Data Source
  KAKENHI-PROJECT-20390001
[Presentation] Total Synthesis of Amphidinolide Q2010
- Author(s)
  石山玄明(小林淳一)
- Organizer
  2010 International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  Hilton Hawaiian Village (USA)
- Year and Date
  2010-12-18
- Data Source
  KAKENHI-PROJECT-20390001

1. KOBAYASHI Jun'ichi (90221241)

# of Collaborated Projects: 7 results

# of Collaborated Products: 11 results
2. KUBOTA Takaaki (60399954)

# of Collaborated Projects: 5 results

# of Collaborated Products: 4 results
3. TSUDA Masashi (10261322)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. MORITA Hiroshi (70220069)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TANAKA Naonobu (40455598)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TAKEYA Koichi (20120149)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HIRASAWA Yusuke (90434183)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 南雲清二 (80097162)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 飯塚徹 (70328920)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 四元英臣 (80339522)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 五ノ井透

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ISHIYAMA Haruaki 石山 玄明

石山 玄明 イシヤマ ハルアキ

Research Projects

Research Products

Co-Researchers

Development of new antitumor agents and immunosuppressive agents using brasilicardin-A as a lead compound

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research and development of bioactive marine natural products

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Synthesis of eudistomin D analogues and its effects on adenosine receptorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

創薬素材としての細胞骨格系機能性分子の探索

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

渦鞭毛藻由来の細胞毒性マクロリド・アンフィジノリドNの立体化学の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

がん分子標的に特異的に作用する天然薬物の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research for Antitumor Crude Drug from Malaysian Unutilized Plant Resorces

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

がん分子標的に特異的に作用する天然薬物の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

海洋産新規抗腫瘍性マクロリド・アンフィジノリドAの立体化学の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research and development of bioactive natural products targeting cytoskeleton.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

特異な環構造を有するアルカロイドpyrinodemin Aの絶対立体化学の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Amphidinin G, a putative precursor of amphidinin A from marine dinoflagellate Amphidinium sp.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of the C1-C7 and C8-C18 segments of ent-amphidinin A2014

Author(s)

Journal Title

DOI

ISHIYAMA Haruaki 石山玄明

石山玄明イシヤマハルアキ