Takai Toshiro 高井敏朗

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TAKAI Toshiro 高井敏朗

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Researcher Number	70338375
Other IDs	https://orcid.org/0000-0001-8363-0355
External Links
Affiliation (Current)	2024: 順天堂大学, 大学院医学研究科, 教授
Affiliation (based on the past Project Information) *help	2021 – 2022: 順天堂大学, 大学院医学研究科, 先任准教授 2018 – 2020: 順天堂大学, 医学(系)研究科(研究院), 准教授 2012 – 2016: 順天堂大学, 医学(系)研究科(研究院), 准教授 2014: 順天堂大学, 医学部, 准教授 2011 – 2012: 順天堂大学, 大学院・医学研究科, 准教授 … More 2010: 順天堂大学, 医学研究科, 准教授 2006: JUNTENDO UNIVERSITY SCHOOL OF MEDICINE, ATOPY (ALLERGY) RESEARCH CENTER, ASSISTANT PROFESSOR, 大学院医学研究科, 講師 2005: 順天堂大学, 大学院・医学研究科, 講師 2004: 順天堂大学, 医学部, 助手 2002 – 2003: 順天堂大, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / Dermatology / アレルギー / 応用微生物学・応用生物化学 Except Principal Investigator Otorhinolaryngology
Keywords	Principal Investigator マウスモデル / プロテアーゼアレルゲン / 経皮感作 / 皮膚炎症 / Der f 1 / Der p 1 / IgE / アレルギーマーチ / アトピー性皮膚炎 / かゆみ … More / 免疫 / バリア / プロテアーゼ抗原 / 痒み / プロテアーゼ / Th17 / Th2 / 予防・治療戦略 / recombinant alelrgen / allergen vaccine / allergen-specific immunotherapy / Th2 eliciting activity / cysteine protease / house dust mite allergens / 組換アレルゲン / アレルゲンワクチン / 減感作療法 / Th2誘導活性 / システインプロテアーゼ / ダニアレルゲン / 洗剤モデル / 模擬引っ掻きモデル / バリア破壊 / IgE/Th2/Th17 / TLR / フラジェリン / 黄色ブドウ球菌 / 経路 / TSLP / ケラチノサイト / アレルギー / 再生医学 … More Except Principal Investigator 上皮間電位差 / 上皮水分蒸散量 / 早期介入 / アレルギーマーチ / スギ花粉症 / PolyI: C / poly I:C / LPS / TSLP / 鼻粘膜上皮バリア機能 / アレルギーの先制医療 / 花粉症の初期治療 / ドライノーズ / 鼻粘膜上皮 / 花粉症 / アレルギー性鼻炎 / フィラグリン / バリア機能 Less

Interplay among barrier, immunity and itch in epicutaneous allergen sensitizationPrincipal Investigator
- Principal Investigator
  
  高井敏朗
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Juntendo University
Analysis of inflammation and sensitization on epicutaneous antigen exposurePrincipal Investigator
- Principal Investigator
  
  Takai Toshiro
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Juntendo University
Roles of protease allergen in epicutaneous sensitizationPrincipal Investigator
- Principal Investigator
  
  Takai Toshiro
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Juntendo University
Molecular mechanism of barrier function in human nasal mucosal epithelia
- Principal Investigator
  
  MIWA Masato
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Juntendo University
Induction of TSLP by environmental and self factors associated with atopic dermatitisPrincipal Investigator
- Principal Investigator
  
  TAKAI Toshiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Juntendo University
ANALYSIS OF IGE-SENSITIZATION DEPENDENT ON CYSTEINE PROTEASE ACTIVITY OF MITE MAJOR ALLERGENSPrincipal Investigator
- Principal Investigator
  
  TAKAI Toshiro
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  アレルギー
- Research Institution
  JUNTENDO UNIVERSITY
ダニアレルゲン蛋白質の高次構造に焦点をあてたIgEエピトープ解析及びワクチン設計Principal Investigator
- Principal Investigator
  
  高井敏朗
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  Juntendo University

[Book] Methods in Enzymology: Endosomal Signaling: TSLP expression induced via Toll-like receptor pathways in human keratinocytes2013
- Author(s)
  Toshiro Takai
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-22591251
[Book] Handbook of Proteolytic Enzymes: Serine endopeptidase allergens from Dermatophagoides species2013
- Author(s)
  Toshiro Takai
- Publisher
  Academic Press
- Data Source
  KAKENHI-PROJECT-22591251
[Book] Mite endopeptidase 1. In: Neil D. Rawlings and Guy S2013
- Author(s)
  Takai T
- Publisher
  alvesen, editors, Handbook of Proteolytic Enzymes. Oxford: Academic Press
- Data Source
  KAKENHI-PROJECT-22591251
[Book] Serine endopeptidase allergens from Dermatophagoidesspecies. In: Neil D. Rawlings and Guy S2013
- Author(s)
  Takai T
- Publisher
  Salvesen, editors, Handbook of Proteolytic Enzymes. Oxford: Academic Press
- Data Source
  KAKENHI-PROJECT-22591251
[Book] Handbook of Proteolytic Enzymes: Mite endopeptidase 12013
- Author(s)
  Toshiro Takai
- Publisher
  Academic Press
- Data Source
  KAKENHI-PROJECT-22591251
[Book] 先端医療シリーズ38皮膚疾患の最新医療2006
- Author(s)
  高井敏朗
- Total Pages
  318
- Publisher
  先端医療技術研究所(東京)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16616009
[Journal Article] Antigen protease activity with a detergent induces severe skin inflammation with itch and robust Th17/Th22 differentiation in mice2023
- Author(s)
  Yoshimura T, Kamijo S, Ichikawa S, Kimitsu T, Masutani Y, Shimizu S, Takada K, Ogawa T, Tominaga M, Takamori K, Ogawa H, Okumura K, Ikeda S, Takai T
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: in-press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08529
[Journal Article] Skin Treatment with Detergent Induces Dermatitis with H1-Antihistamine-Refractory Itch and Upregulates IL-4 and Th17/Th22 Cytokine Gene Expression in C57BL/6 Mice2022
- Author(s)
  Masutani Yurie、Takai Toshiro、Kamijo Seiji、Kimitsu Toru、Yoshimura Tomoko、Ichikawa Saori、Shimizu Saya、Ogawa Takasuke、Takada Keiko、Tominaga Mitsutoshi、Suto Hajime、Takamori Kenji、Ogawa Hideoki、Okumura Ko、Ikeda Shigaku
- Journal Title
  
  International Archives of Allergy and Immunology
  
  Volume: 183 Issue: 10 Pages: 1040-1049
- DOI
  10.1159/000525656
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08439, KAKENHI-PROJECT-22K08529, KAKENHI-PROJECT-23K20320, KAKENHI-PROJECT-23K24217
[Journal Article] アレルゲンのプロテアーゼ活性と免疫応答2022
- Author(s)
  高井敏朗
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 77 Pages: 405-410
- Data Source
  KAKENHI-PROJECT-18K08417
[Journal Article] アレルゲンのプロテアーゼ活性と免疫応答2022
- Author(s)
  高井敏朗, 上條清嗣
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 77 Pages: 405-410
- Data Source
  KAKENHI-PROJECT-22K08529
[Journal Article] Epicutaneous challenge with protease allergen requires its protease activity to recall TH2 and TH17/TH22 responses in mice pre-sensitized via distant skin2021
- Author(s)
  Ogasawara A, Yuki T, Takai T, Yokozeki K, Katagiri A, Takahashi Y, Yokozeki H, Basketter D, Sakaguchi H
- Journal Title
  
  J Immunotoxicol
  
  Volume: 18 Issue: 1 Pages: 118-126
- DOI
  10.1080/1547691x.2021.1968548
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08417
[Journal Article] パパインの皮下感作におけるIL-17AによるIL-33非依存性好酸球炎症とIgE反応の増強2021
- Author(s)
  上條清嗣, 原むつ子, 鈴木麻友, 中江進, 小川秀興, 奧村康, 高井敏朗
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 75 Pages: 299-306
- Data Source
  KAKENHI-PROJECT-18K08417
[Journal Article] Inhibition of both cyclooxygenase-1 and -2 promotes epicutaneous Th2 and Th17 sensitization and allergic airway inflammation on subsequent airway exposure to protease allergen in mice2021
- Author(s)
  Suchiva, P., Takai, T., Kamijo, S., Maruyama, N., Yokomizo, T., Sugimoto, Y., Okumura, K., Ikeda, S., Ogawa, H.
- Journal Title
  
  International Archives of Allergy and Immunology
  
  Volume: - Issue: 9 Pages: 788-799
- DOI
  10.1159/000514975
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22503, KAKENHI-PROJECT-17H03990, KAKENHI-PROJECT-18K08417, KAKENHI-PROJECT-21H04798, KAKENHI-PROJECT-21H02633, KAKENHI-PROJECT-19KK0199
[Journal Article] Epicutaneous vaccination with protease inhibitor-treated papain prevents papain-induced Th2-mediated airway inflammation without inducing Th17 in mice2021
- Author(s)
  Kunimine S, Takai T, Kamijo S, Maruyama N, Kimitsu T, Masutani Y, Yoshimura T, Suchiva P, Shimizu S, Ogawa H, Okumura K, Ikeda S
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 546 Pages: 192-199
- DOI
  10.1016/j.bbrc.2020.12.090
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08417, KAKENHI-PROJECT-17K10007
[Journal Article] ALLERGEN BASICS: FROM COMPONENTS TO IMMUNOLOGY2021
- Author(s)
  高井敏朗
- Journal Title
  
  Japanese Journal of Allergology
  
  Volume: 70 Issue: 4 Pages: 255-262
- DOI
  10.15036/arerugi.70.255
- NAID
  130008052595
- ISSN
  0021-4884, 1347-7935
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08417
[Journal Article] Innate IL-17A enhances IL-33-independent skin eosinophilia and IgE response on subcutaneouspapain sensitization2021
- Author(s)
  Kamijo S, Hara M, Suzuki M, Nakae S, Ogawa H, Okumura K, Takai T
- Journal Title
  
  J Invest Dermatol
  
  Volume: 141 Issue: 1 Pages: 105-113.e14
- DOI
  10.1016/j.jid.2020.05.088
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08417, KAKENHI-PROJECT-18H02847, KAKENHI-PROJECT-17K10007, KAKENHI-PROJECT-21H02963
[Journal Article] アレルゲンと自然免疫2020
- Author(s)
  高井敏朗, 上條清嗣
- Journal Title
  
  臨床免疫アレルギー科
  
  Volume: 73 Pages: 160-167
- Data Source
  KAKENHI-PROJECT-18K08417
[Journal Article] Innate IL-17A enhances IL-33-independent skin eosinophilia and IgE response on subcutaneous papain sensitization2020
- Author(s)
  Kamijo S, Hara M, Suzuki M, Nakae S, Ogawa H, Okumura K, Takai T
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: in-press
- NAID
  40022504096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08417
[Journal Article] 2 病態の新しい考え方　7) ダニの関与2019
- Author(s)
  高井敏朗
- Journal Title
  
  皮膚科の臨床 (増刊　変わりつつあるアトピー性皮膚炎の常識-最新の知識と治療の極意-)
  
  Volume: 61 Pages: 759-764
- Data Source
  KAKENHI-PROJECT-18K08417
[Journal Article] Cyclooxygenase inhibition in mice hightens adaptive-and innate-type responses against inhaled protease allergen and IL-332019
- Author(s)
  Maruyama N, Takai T, Kamijo S, Suchiva P, Takeshige T, Suzuki M, Hara M, Matsuno K, Harada S, Narada N, Nakae S, Sudo K, Okuno T, Yokomizo T, Ogawa H, Okumura K, Ikeda S.
- Journal Title
  
  Allergy
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08417
[Journal Article] ダニの関与2019
- Author(s)
  高井敏朗
- Journal Title
  
  皮膚科の臨床臨時増刊「変わりつつあるアトピー性皮膚炎の常識-最新の知識と治療の極意-」
  
  Volume: 60
- Data Source
  KAKENHI-PROJECT-18K08417
[Journal Article] Cyclooxygenase inhibition in mice heightens adaptive‐ and innate‐type responses against inhaled protease allergen and IL ‐332019
- Author(s)
  Maruyama Natsuko、Takai Toshiro、Kamijo Seiji、Suchiva Punyada、Ohba Mai、Takeshige Tomohito、Suzuki Mayu、Hara Mutsuko、Matsuno Kei、Harada Sonoko、Harada Norihiro、Nakae Susumu、Sudo Katsuko、Okuno Toshiaki、Yokomizo Takehiko、Ogawa Hideoki、Okumura Ko、Ikeda Shigaku
- Journal Title
  
  Allergy
  
  Volume: 印刷中 Issue: 11 Pages: 2237-2240
- DOI
  10.1111/all.13831
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09554, KAKENHI-PROJECT-16K09587, KAKENHI-PROJECT-17K10007, KAKENHI-PROJECT-18K08417, KAKENHI-PROJECT-19K07357, KAKENHI-PROJECT-19KK0199, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05904, KAKENHI-PROJECT-18H02627, KAKENHI-PROJECT-18H02847, KAKENHI-PROJECT-16K08596
[Journal Article] アレルゲンのアジュバント作用2019
- Author(s)
  高井敏朗
- Journal Title
  
  日本職業・環境アレルギー学会雑誌
  
  Volume: 26 Pages: 1-8
- NAID
  40021984974
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08417
[Journal Article] Airway inflammation after epicutaneous sensitization of mice requires protease activity of low-dose allergen inhalation.2018
- Author(s)
  Nishioka I, Takai T, Maruyama N, Kamijo S, Suchiva P, Suzuki M, Kunimine S, Ochi H, Shimura S, Sudo K, Ogawa H, Okumura K, Ikeda S.
- Journal Title
  
  J Allergy Clin Immunol
  
  Volume: 印刷中 Issue: 6 Pages: 2271-2273
- DOI
  10.1016/j.jaci.2017.11.035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10007, KAKENHI-PROJECT-26860759, KAKENHI-PROJECT-18K08417
[Journal Article] Skin treatment with detergent promotes protease allergen-dependent epicutaneous sensitization in a manner different from tape stripping in mice2017
- Author(s)
  Ochi H, Takai T, Shimura S, Maruyama N, Nishioka I, Kamijo S, Iida H, Nakae S, Ogawa H, Okumura K, Ikeda S
- Journal Title
  
  J Invest Dermatol
  
  Volume: 掲載確定 Issue: 7 Pages: 1578-1582
- DOI
  10.1016/j.jid.2017.02.970
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461711, KAKENHI-PROJECT-17K10007, KAKENHI-PROJECT-26860759
[Journal Article] 好塩基球の自然免疫応答によるIL-4産生のFc受容体γ鎖依存性2016
- Author(s)
  高井敏朗, 上條清嗣, 布村聡, 羅智靖, 小川秀興, 奧村康
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 66 Pages: 371-374
- Data Source
  KAKENHI-PROJECT-25461711
[Journal Article] 家塵ダニアレルゲンの性状と標準化2016
- Author(s)
  高井敏朗
- Journal Title
  
  喘息・アレルギー
  
  Volume: 29 Pages: 15-19
- Data Source
  KAKENHI-PROJECT-25461711
[Journal Article] Subcutaneous Allergic Sensitization to Protease Allergen Is Dependent on Mast Cells but Not IL-33: Distinct Mechanisms between Subcutaneous and Intranasal Routes2016
- Author(s)
  Kamijo S, Suzuki M, Hara M, Shimura S, Ochi H, Maruyama N, Matsuda A, Saito H, Nakae S, Suto H, Ichikawa S, Ikeda S, Ogawa H, Okumura K, Takai T.
- Journal Title
  
  J Immunol
  
  Volume: 196 Issue: 9 Pages: 3559-3569
- DOI
  10.4049/jimmunol.1500717
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860759, KAKENHI-PROJECT-15H04866, KAKENHI-PROJECT-26293087, KAKENHI-PROJECT-25461711, KAKENHI-PROJECT-26462698
[Journal Article] Innate basophil IL-4 responses against allergens, endotoxin, and cytokines require the Fc receptor γ-chain.2016
- Author(s)
  Kamijo S, Nunomura S, Ra C, Kanaguchi Y, Suzuki Y, Ogawa H, Okumura K, Takai T.
- Journal Title
  
  J Allergy Clin Immunol
  
  Volume: 137 Issue: 5 Pages: 1613-1615
- DOI
  10.1016/j.jaci.2015.10.037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293087, KAKENHI-PROJECT-25461711, KAKENHI-PROJECT-26860759
[Journal Article] 環境アレルゲン2016
- Author(s)
  高井敏朗
- Journal Title
  
  日本医師会雑誌特別号「アレルギー疾患の全て
  
  Volume: 145
- Data Source
  KAKENHI-PROJECT-25461711
[Journal Article] Epicutaneous allergic sensitization by cooperation between allergn protease activity and mechanical skin barrier damage in mice2016
- Author(s)
  Shimura S, Takai T, Iida H, Maruyama N, Ochi H, Kamijo S, Nishioka I, Hara M, Matsuda A, Saito H, Nakae S, Ogawa H, Okumura K, Ikeda S.
- Journal Title
  
  J Invest Dermatol
  
  Volume: 136 Issue: 7 Pages: 1408-1417
- DOI
  10.1016/j.jid.2016.02.810
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04866, KAKENHI-PROJECT-26293087, KAKENHI-PROJECT-25461711, KAKENHI-PROJECT-26462698, KAKENHI-PROJECT-26860759
[Journal Article] Presensitization to Ascaris antigens promotes induction of mite-speciﬁc IgE upon mite antigen inhalation in mice2016
- Author(s)
  Suzuki M, Hara M, Ichikawa S, Kamijo S, Nakazawa T, Hatanaka H, Akiyama K, Ogawa H, Okumura K, Takai T
- Journal Title
  
  Allergol. Int.
  
  Volume: 65 Issue: 1 Pages: 44-51
- DOI
  10.1016/j.alit.2015.07.003
- NAID
  130005290333
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461711, KAKENHI-PROJECT-26860759, KAKENHI-PROJECT-26293087
[Journal Article] 専門医のためのアレルギー講座：アレルゲンとその修飾因子2016
- Author(s)
  高井敏朗
- Journal Title
  
  アレルギー（日本アレルギー学会誌）
  
  Volume: 65 Pages: 159-165
- Data Source
  KAKENHI-PROJECT-25461711
[Journal Article] Japanese Society of Allergology task force report on standardization of house dust mite allergen vaccines - Secondary publication2015
- Author(s)
  Takai T, Okamoto Y, Okubo K, Nagata M, Sakaguchi M, Fukutomi Y, Saito A, Yasueda H, Masuyama K
- Journal Title
  
  Allergol. Int.
  
  Volume: 64 Issue: 2 Pages: 181-186
- DOI
  10.1016/j.alit.2015.01.005
- NAID
  130005290283
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24791017, KAKENHI-PROJECT-25461711, KAKENHI-PROJECT-15K07756
[Journal Article] IL-33とアレルゲン2015
- Author(s)
  高井敏朗
- Journal Title
  
  医学のあゆみ
  
  Volume: 252 Pages: 1226-1232
- Data Source
  KAKENHI-PROJECT-25461711
[Journal Article] Cysteine protease antigens cleave CD123, the α subunit of murine IL-3 receptor, on basophils and suppress IL-3-mediated basophil expansion2015
- Author(s)
  Nishikado H, Fujimura T, Taka H, Mineki R, Ogawa H, Okumura K, Takai T
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 印刷中 Issue: 2 Pages: 261-266
- DOI
  10.1016/j.bbrc.2015.03.022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461711, KAKENHI-PROJECT-15K00569, KAKENHI-PROJECT-26430145, KAKENHI-PROJECT-26293087
[Journal Article] Allergens in modern society: Updated catalogs and future prospects2015
- Author(s)
  Takai T, Izuhara K
- Journal Title
  
  Allergol. Int.
  
  Volume: 64 Issue: 4 Pages: 293-294
- DOI
  10.1016/j.alit.2015.08.003
- NAID
  130005290405
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Open Access
- Data Source
  KAKENHI-PROJECT-25461711
[Journal Article] Immunotherapy to treat allergies: Recent advances and future prospects2015
- Author(s)
  Takai T
- Journal Title
  
  Juntendo Medical Journal
  
  Volume: 61 Pages: 597-560
- NAID
  130005133289
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461711
[Journal Article] Pectate lyase pollen allergens: Sensitization profiles and cross-reactivity pattern2015
- Author(s)
  Pichler U, Hauser M, Wolf M, Bernardi ML, Gadermaier G, Weiss R, Ebner C, Yokoi H, Takai T, Didierlaurent A, Rafaiani C, Briza P, Mari A, Behrendt H, Wallner M, Ferreira F
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 5 Pages: e0120038-e0120038
- DOI
  10.1371/journal.pone.0120038
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461711
[Journal Article] Epicutaneous Administration of Papain Induces IgE and IgG Responses in a Cysteine Protease Activity-Dependent Manner2014
- Author(s)
  Iida H, Takai T, Hirasawa Y, Kamijo S, Shimura S, Ochi H, Nishioka I, Maruyama N, Ogawa H, Okumura K, Ikeda S
- Journal Title
  
  Allergol. Int.
  
  Volume: 63 Issue: 2 Pages: 219-226
- DOI
  10.2332/allergolint.13-OA-0621
- NAID
  130004477213
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461711, KAKENHI-PROJECT-26293087, KAKENHI-PROJECT-26860759
[Journal Article] Repeated antigen painting and sublingual immunotherapy in mice convert sublingual dendritic cell subsets2014
- Author(s)
  Zhang C, Ohno T, Kang S, Takai T, Azuma M
- Journal Title
  
  Vaccine
  
  Volume: 32 Issue: 43 Pages: 5669-5676
- DOI
  10.1016/j.vaccine.2014.08.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461711, KAKENHI-PROJECT-26253086
[Journal Article] 環境アレルゲン解析の進歩2014
- Author(s)
  高井敏朗
- Journal Title
  
  小児科診療
  
  Volume: 77 Pages: 1241-1247
- Data Source
  KAKENHI-PROJECT-25461711
[Journal Article] TSLP expression induced via Toll-like receptor pathways in human keratinocytes2014
- Author(s)
  Takai T, Chen X, Xie Y, Vu AT, Le TA, Kinoshita H, Kawasaki J, Kamijo S, Hara M, Ushio H, Baba T, Hiramatsu K, Ikeda S, Ogawa H, Okumura K
- Journal Title
  
  Methods Enzymol
  
  Volume: 535 Pages: 371-387
- DOI
  10.1016/b978-0-12-397925-4.00021-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461711, KAKENHI-PROJECT-26293087, KAKENHI-PROJECT-26860759
[Journal Article] ダニアレルゲンワクチン標準化に関する日本アレルギー学会タスクフォース報告2014
- Author(s)
  46.高井敏朗, 岡本美孝, 大久保公裕, 永田真, 阪口雅弘, 福冨友馬, 齋藤明美, 安枝浩, 増山敬祐
- Journal Title
  
  アレルギー
  
  Volume: 63 Pages: 1229-1240
- NAID
  110009865616
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461711
[Journal Article] Immunization of Rabbits with Nematode <i>Ascaris lumbricoides</i> Antigens Induces Antibodies Cross-Reactive to House Dust Mite <i>Dermatophagoides farinae</i> Antigens2013
- Author(s)
  Nakazawa T, Khan AF, Yasueda H, Saito A, Fukutomi Y, Takai T, Zaman K, Yunus M, Takeuchi H, Iwata T, Akiyama K.
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 77 Issue: 1 Pages: 145-150
- DOI
  10.1271/bbb.120626
- NAID
  10031164704
- ISSN
  0916-8451, 1347-6947
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791017, KAKENHI-PROJECT-25461711
[Journal Article] Immunization of rabbits with nematode Ascaris lumbricoides antigens induces antibodies cross-reactive to house dust mite Dermatophagoides farinae antigens2013
- Author(s)
  Nakazawa T, Khan AF, Yasueda H, Saito A, Fukutomi Y, Takai T, Zaman K, Yunus M, Takeuchi H, Iwata T, Akiyama K
- Journal Title
  
  Biosc Biotechnol Biochem
  
  Volume: 77 Pages: 145-150
- NAID
  10031164704
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] Human antimicrobial peptide LL-37 modulates proinflammatory responses induced by cytokine milieus and double-stranded RNA in human keratinocytes2013
- Author(s)
  Xue Chen
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 433 Issue: 4 Pages: 532-537
- DOI
  10.1016/j.bbrc.2013.03.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591251, KAKENHI-PROJECT-23390260, KAKENHI-PROJECT-23591655, KAKENHI-PROJECT-25461711
[Journal Article] アレルゲンはなぜアレルゲンになるのか？：アレルゲンが引き起こすバリア破壊と自然免疫応答2013
- Author(s)
  高井敏朗
- Journal Title
  
  実験医学
  
  Volume: 31 Pages: 2713-2719
- Data Source
  KAKENHI-PROJECT-25461711
[Journal Article] ダニアレルゲンによる経皮感作のメカニズム2013
- Author(s)
  高井敏朗
- Journal Title
  
  アレルギー・免疫
  
  Volume: 20 Pages: 854-860
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] ダニアレルゲンによる経皮感作のメカニズム2013
- Author(s)
  高井敏朗
- Journal Title
  
  アレルギー・免疫
  
  Volume: 20 Pages: 854-860
- Data Source
  KAKENHI-PROJECT-25461711
[Journal Article] IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation2013
- Author(s)
  Kamijo S, Takeda H, Tokura T, Suzuki M, Inui K, Hara M, Matsuda H, Matsuda A, Oboki K, Ohno T, Saito H, Nakae S, Sudo K, Suto H, Ichikawa S, Ogawa H, Okumura K, Takai T
- Journal Title
  
  J Immunol
  
  Volume: 190 Pages: 4489-99
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation2013
- Author(s)
  Seiji Kamijo
- Journal Title
  
  J Immunol
  
  Volume: 190 Issue: 9 Pages: 4489-4499
- DOI
  10.4049/jimmunol.1201212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591251, KAKENHI-PROJECT-23390260, KAKENHI-PROJECT-25461711
[Journal Article] Human antimicrobial peptide LL-37 modulates proinflammatory responses induced by cytokine milieus and double-stranded RNA in human keratinocytes2013
- Author(s)
  Chen X, Takai T, Xie Y, Francois Niyonsaba. Okumura K. Ogawa H
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 433 Pages: 532-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] 私は思う：アレルゲンとは何か2012
- Author(s)
  高井敏朗
- Journal Title
  
  アレルギーの臨床
  
  Volume: 32 Pages: 739-741
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] TSLP expression: cellular sources,triggers, and regulatory mechanisms2012
- Author(s)
  Takai T
- Journal Title
  
  Allergol Int
  
  Volume: 61 Pages: 3-17
- NAID
  130004873040
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] Long TSLP transcript expression and release of TSLP induced by TLR ligands and cytokines in human keratinocytes2012
- Author(s)
  Xie Y, Takai T, Chen X, Okumura K, Ogawa H
- Journal Title
  
  J Dermatol Sci
  
  Volume: 66 Pages: 233-237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] Th2アジュバントとしての環境アレルゲンと黄色ブドウ菌:経皮的Th2感作におけるバリア破壊と自然免疫応答2012
- Author(s)
  高井敏朗
- Journal Title
  
  日本皮膚アレルギー・接触皮膚炎学会雑誌
  
  Volume: 6 Pages: 8-13
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] 私は思う:アレルゲンとは何か2012
- Author(s)
  高井敏朗
- Journal Title
  
  アレルギーの臨床
  
  Volume: 32 Pages: 739-741
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] TSLP Expression: Cellular Sources, Triggers, and Regulatory Mechanisms2012
- Author(s)
  Toshiro Takai
- Journal Title
  
  Allergol. Int.
  
  Volume: 61 Issue: 1 Pages: 3-17
- DOI
  10.2332/allergolint.11-RAI-0395
- NAID
  130004873040
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] Inhibition of allergen-induced airway inflammation by low-dose oral immunotherapy with transgenic rice seeds independently of immunoglobulin E synthesis2012
- Author(s)
  Saeki M, Nishimura T, Kaminuma O, Suzuki K, Takai T, Mori A, Takada K, Takaiwa F, Hiroi T.
- Journal Title
  
  Int Arch Allergy Immunol
  
  Volume: 158 Pages: 66-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] アレルゲンの3つの顔2012
- Author(s)
  高井敏朗
- Journal Title
  
  アレルギー
  
  Volume: 61 Pages: 930-940
- NAID
  110009489266
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] アレルゲンの持つアジュバント作用と抗原感作機構2012
- Author(s)
  高井敏朗
- Journal Title
  
  アレルギー・免疫
  
  Volume: 19 Pages: 12-19
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] アレルゲンの３つの顔2012
- Author(s)
  高井敏朗
- Journal Title
  
  アレルギー
  
  Volume: 61 Pages: 930-940
- NAID
  110009489266
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] ダニアレルギーとアレルゲン2012
- Author(s)
  高井敏朗
- Journal Title
  
  日本医事新報
  
  Volume: 4582号 Pages: 57-59
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] Extracellular double-stranded RNA induces TSLP via an endosomal acidification- and NF-kB-dependent pathway in human keratinocytes2012
- Author(s)
  Vu AT, Chen X, Xie Y, Kamijo S, Ushio H, Kawasaki J, Hara M, Ikeda S, Okumura K, Ogawa H, Takai T
- Journal Title
  
  J Invest Dermatol
  
  Volume: 131 Pages: 2205-2212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] 鼻粘膜上皮バリア機能からみた花粉抗原の特性2012
- Author(s)
  三輪正人, 高井敏郎, 神谷和作, 塩沢晃人
- Journal Title
  
  順天堂医学
  
  Volume: 58 Pages: 466-466
- Data Source
  KAKENHI-PROJECT-24592580
[Journal Article] ダニアレルギーとアレルゲン2012
- Author(s)
  高井敏朗、池田志斈
- Journal Title
  
  週刊日本医事新報
  
  Volume: 4582号 Pages: 57-59
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] Viral infection induces thymic stromal lymphopoietin (TSLP) in human keratinocyte2011
- Author(s)
  Kawasaki J, Ushio H, Kinoshita H, Fukai T, Niyonsaba F, Takai T, Ogawa H, Okumura K, Ikeda S
- Journal Title
  
  J Dermatol Sci
  
  Volume: 62 Pages: 131-134
- NAID
  10030891266
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] 表皮ケラチノサイトにおけるTSLP 産生誘導2011
- Author(s)
  高井敏朗
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 55 Pages: 365-370
- NAID
  40018789102
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] Missions of protease allergens in the epithelium2011
- Author(s)
  Takai T
- Journal Title
  
  Int Arch Allergy Immunol
  
  Volume: 154 Pages: 3-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] Flagellin induces the expression of thymic stromal lymphopoietin in human keratinocytes via Toll-like receptor 52011
- Author(s)
  Le TA, Takai T, Vu AT, Kinoshita H, Chen X, Ikeda S, Ogawa H, Okumura K
- Journal Title
  
  Int Arch Allergy Immunol
  
  Volume: 155 Pages: 31-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] Prevention of allergic asthma by vaccination with transgenic rice seed expressing mite allergen: induction of allergen-specific oral tolerance without bystander suppression2011
- Author(s)
  Suzuki K, Kaminuma O, Yang L, Takai T, Mori A, Umezu-Goto M, Ohtomo T, Ohmachi Y, Noda Y, Hirose S, Okumura K, Ogawa H, Takada K, Hirasawa M, Hiroi T, Takaiwa F
- Journal Title
  
  Plant Biotechnol J
  
  Volume: 9 Pages: 982-990
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] アレルゲンはなぜアレルゲンになるのか2011
- Author(s)
  高井敏朗
- Journal Title
  
  アレルギー(日本アレルギー学会誌)
  
  Volume: 60 Pages: 809-816
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] 表皮ケラチノサイトにおけるTSLP産生誘導2011
- Author(s)
  高井敏朗
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 55 Pages: 365-370
- NAID
  40018789102
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] Barrier dysfunction caused by environmental proteases in the pathogenesis of allergic diseases2011
- Author(s)
  Takai T, Ikeda S
- Journal Title
  
  Allergol Int
  
  Volume: 60 Pages: 25-35
- NAID
  10031143296
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] アレルゲンはなぜアレルゲンになるのか2011
- Author(s)
  高井敏朗
- Journal Title
  
  アレルギー
  
  Volume: 60 Pages: 809-816
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] 花粉の Th2 アジュバント活性2010
- Author(s)
  高井敏朗、上條清嗣
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 54 Pages: 625-630
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] 知っておかなければならないアレルギー疾患の基礎知識2010
- Author(s)
  高井敏朗
- Journal Title
  
  (2) Th2 アジュバントとしてのアレルゲンアレルギー・免疫
  
  Volume: 17 Pages: 687-694
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] 樹状細胞の花粉成分による Th2 細胞誘導2010
- Author(s)
  上條清嗣、奥村康、高井敏朗
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 54 Pages: 313-322
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] Proinflammatory response in human keratinocytes stimulated with ligands for TLR2, TLR1, and TLR62010
- Author(s)
  Vu AT, Takai T, Le TA, Kinoshita H, Kamijo S, Hara M, Wang XL, Ogawa T, Ikeda S, Ogawa H, Okumura K
- Journal Title
  
  Juntendo Medical Journal
  
  Volume: 56 Pages: 50-55
- NAID
  10029497982
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] Staphylococcus aureus membrane and diacylated lipopeptide induce thymic stromal lymphopoietin in keratinocytes via the Toll-like receptor 2-Toll-like receptor 6 pathway2010
- Author(s)
  Vu AT, Baba T, Chen X, Le TA, Kinoshita H, Xie Y, Kamijo S, Hiramatsu K, Ikeda S, Ogawa H, Okumura K, Takai T
- Journal Title
  
  J Allergy Clin Immunol
  
  Volume: 126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] 花粉による樹状細胞の活性化2010
- Author(s)
  上條清嗣、奥村康、高井敏朗
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 53 Pages: 312-320
- NAID
  40017058245
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] アレルゲンに対する自然免疫応答2010
- Author(s)
  高井敏朗
- Journal Title
  
  呼吸
  
  Volume: 29 Pages: 878-883
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] ダニに由来する Th2 アジュバント活性2010
- Author(s)
  高井敏朗
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 54 Pages: 619-624
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] lucocorticoids inhibit double-stranded RNA-induced thymic stromal lymphopoietin release from keratinocytes in atopic cytokine milieu more effectively than tacrolimus2010
- Author(s)
  Le TA, Takai T, Vu AT, Kinoshita H, Ikeda S, Ogawa H, Okumura K
- Journal Title
  
  Int Arch Allergy Immunol
  
  Volume: 153 Pages: 27-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] Cedar allergen harvest from tobacco: Plant biotechnology for recombinant allergens2010
- Author(s)
  Takai T
- Journal Title
  
  Int Arch Allergy Immunol
  
  Volume: 153 Pages: 431-433
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] Staphylococcus aureus extracellular protease causes epidermal barrier dysfunction2010
- Author(s)
  Hirasawa Y, Takai T, Nakamura T, Mitsuishi K, Gunawan H, Suto H,Ogawa T, Wang XL, Ikeda S, Okumura K, Ogawa H
- Journal Title
  
  J Invest Dermatol
  
  Volume: 130 Pages: 614-617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] 環境因子とアレルギー疾患-特にアトピー性皮膚炎を中心にー2010
- Author(s)
  奥村康、高井敏朗
- Journal Title
  
  日中医学
  
  Volume: 24 Pages: 47-52
- NAID
  10026237937
- Data Source
  KAKENHI-PROJECT-22591251
[Journal Article] ダニグループ1アレルゲン組換体の作製とその活性2006
- Author(s)
  高井敏朗
- Journal Title
  
  アレルギー・免疫 19
  
  Pages: 332-333
- Data Source
  KAKENHI-PROJECT-16616009
[Journal Article] ダニグルプ1アレルゲン組換体の作製とその活性2006
- Author(s)
  高井敏朗
- Journal Title
  
  アレルギー・免疫 19
  
  Pages: 332-333
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16616009
[Journal Article] Glycosylation of recombinant proforms of major house dust mite allergens Der p 1 and Der f 1 decelerates the speed of maturation2006
- Author(s)
  Toshiro Takai
- Journal Title
  
  Int Arch allergy Immunol 139
  
  Pages: 181-187
- Data Source
  KAKENHI-PROJECT-16616009
[Journal Article] Application of immunoreaction enhancer solutions to an enzyme-linked immunosorbent assay for antigen-specific IgE in mice immunized with recombinant major mite allergens or ovalbumin2006
- Author(s)
  Kikuchi Y, Takai T, Ota M, Kato T, Takeda K, Mitsuishi K, Ikeda S, Okumura K, Ogawa H
- Journal Title
  
  Int Arch Allergy Immunol 141
  
  Pages: 322-330
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616009
[Journal Article] Glycosylation of recombinant proforms of major house dust mite allergens Der p 1 and Der f 1 decelerates the speed of maturation2006
- Author(s)
  Toshiro Takai
- Journal Title
  
  Int Arch Allergy Immunol 139
  
  Pages: 181-187
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16616009
[Journal Article] Glycosylation of recombinant proforms of major mite allergens Der p 1 and Der f 1 decelerates the speed of maturation2006
- Author(s)
  Takai T, Mizuuchi E, Kikuchi Y, Nagamune T, Okumura K, Ogawa H.
- Journal Title
  
  Int Arch Allergy Immunol 139
  
  Pages: 181-187
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616009
[Journal Article] Reduction of skin barrier function by proteolytic activity of a recombinant house dust mite allergen Der f 12006
- Author(s)
  Nakamura T, Hirasawa Y, Takai T, Mitsuishi K, Okuda M, Kato T, Okumura K, Ikeda S, Ogawa H.
- Journal Title
  
  J Invest Dermatol 126
  
  Pages: 2719-2723
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616009
[Journal Article] ダニアレルゲン研究の現状2006
- Author(s)
  高井敏朗
- Journal Title
  
  臨床免疫・アレルギー科 46
  
  Pages: 619-625
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16616009
[Journal Article] Glycosylation of recombinant proforms of major house dust mite allergens Der p 1 and Der F 1 decelerates the speed of maturation2006
- Author(s)
  Toshiro Takai
- Journal Title
  
  Int Arch Allergy Immunol 139
  
  Pages: 181-187
- Data Source
  KAKENHI-PROJECT-16616009
[Journal Article] Crucial commitment of proteolytic activity of a purified recombinant major house dust mite allergen Der p 1 to sensitization towards IgE and IgG responses2006
- Author(s)
  Kikuchi Y, Takai T, Kuhara T, Ota M, Kato T, Hatanaka H, Ichikawa S, Tokura T, Akiba H, Mitsuishi K, Ikeda S, Okumura K, Ogawa H
- Journal Title
  
  J Immunol 177
  
  Pages: 1609-1617
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616009
[Journal Article] Multiple-mutation at a potential ligand-binding region decreased allergenicity of a mite allergen Der f 2 without disrupting global structure2005
- Author(s)
  Nakazawa T, Takai T, Hatanaka H, Mizuuchi E, Nagamune T, Okumura K, Ogawa H.
- Journal Title
  
  FEBS Lett 579
  
  Pages: 1988-1994
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616009
[Journal Article] NMR study on the major mite allergen Der f 2 : Its refined tertiary structure, epitopes for monoclonal antibodies and characteristics shared by ML protein group members2005
- Author(s)
  Ichikawa S, Takai T, Inoue T, Yuuki T, Okumura Y, Ogura K, Inagaki F, Hatanaka H.
- Journal Title
  
  J Biochem 137
  
  Pages: 255-263
- NAID
  10017343554
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616009
[Journal Article] Recombinant Der p 1 and Der f 1 exhibit cysteine protease activity but no serine protease activity.2005
- Author(s)
  Toshiro Takai
- Journal Title
  
  Biochem Biophys Res Commun 329
  
  Pages: 944-952
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16616009
[Journal Article] Analysis of the structure and allergenicity of recombinant pro- and mature Der p 1 and Der f 1: Major conformational IgE-epitopes blocked by prodomains.2005
- Author(s)
  Toshiro Takai
- Journal Title
  
  J Allergy Clin Immunol 115
  
  Pages: 555-563
- Data Source
  KAKENHI-PROJECT-16616009
[Journal Article] Recombinant Der p 1 and Der f 1 with in vitro enzymatic activity to cleave human CD23, CD25 and alpha1-antitrypsin, and in vivo IgE-eliciting activity in mice.2005
- Author(s)
  Toshiro Takai
- Journal Title
  
  Int Arch Allergy Immunol 137
  
  Pages: 194-200
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16616009
[Journal Article] Cystatin A inhibits IL-8 production by keratinocytes stimulated with Der p 1 and Der f 1 : Biochemical skin barrier against mite proteases2005
- Author(s)
  Kato T, Takai T, Mitsuishi K, Okumura K, Ogawa H.
- Journal Title
  
  J Allergy Clin Immunol 116
  
  Pages: 169-176
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616009
[Journal Article] Dilution-method to refold bacterially expressed recombinant Der f 2 and Der p 2 to exhibit the secondary structure and histamine-releasing activity of natural allergens.2005
- Author(s)
  Takai T, Takaoka M, Yasueda H, Okumura K, Ogawa H.
- Journal Title
  
  Int Arch Allergy Immunol 137
  
  Pages: 1-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616009
[Journal Article] Recombinant Der p 1 and Der f 1 with in vitro enzymatic activity to cleave human CD23, CD25, and □ 1-antitrypsin, and in vivo IgE-eliciting activity in mice2005
- Author(s)
  Takai T, Kato T, Ota M, Yasueda H, Kuhara T, Okumura K, Ogawa H.
- Journal Title
  
  Int Arch Allergy Immunol 137
  
  Pages: 194-200
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616009
[Journal Article] Analysis of the structure and allergenicity of recombinant pro- and mature Der p 1 and Der f 1 : Major conformational IgE-epitopes blocked by prodomains.2005
- Author(s)
  Toshiro Takai
- Journal Title
  
  J Allergy Clin Immunol 115
  
  Pages: 555-563
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16616009
[Journal Article] Dilution-method to refold bacterially expressed recombinant Der f 2 and Der p 2 to exhibit the secondary structure and histamine-releasing activity of natural allergens2005
- Author(s)
  Toshiro Takai
- Journal Title
  
  Int Arch Allergy Immunol 137
  
  Pages: 1-8
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16616009
[Journal Article] ダニ主要アレルゲンの構造と機能2005
- Author(s)
  高井敏朗
- Journal Title
  
  臨床検査 49
  
  Pages: 739-747
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16616009
[Journal Article] Recombinant Der p 1 and Der f 1 exhibit cysteine protease activity but no serine protease activity2005
- Author(s)
  Takai T., Kato T, Sakata Y, Yasueda H, Izuhara K, Okumura K, Ogawa H.
- Journal Title
  
  Biochem Biophys Res Commun 328
  
  Pages: 944-952
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616009
[Journal Article] IgE産生とイエチリダニ由来プロテアーゼ2005
- Author(s)
  高井敏朗
- Journal Title
  
  臨床免疫 44
  
  Pages: 541-545
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16616009
[Journal Article] Analysis of the structure and allergenicity of recombinant pro-and mature Der p 1 and Der f 1 : Major conformational IgE-epitopes blocked by prodomains2005
- Author(s)
  Takai T, Kato T, Yasueda H, Okumura K, Ogawa H.
- Journal Title
  
  J Allergy Clin Immunol 115
  
  Pages: 555-563
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616009
[Journal Article] アレルゲンの構造と機能 : アレルギー発症との関連と、治療への新しいアプローチ2004
- Author(s)
  高井敏朗
- Journal Title
  
  喘息 17
  
  Pages: 15-20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16616009
[Journal Article] Characterization of novel squamous cell carcinoma antigen -related molecules in mice2004
- Author(s)
  Sakata Y, Arima K, Takeshita K, Takai T, Aoki S, Ogawa H, Sugihara H, Fujimoto K, Izuhara K.
- Journal Title
  
  Biochem Biophys Res Commun 324
  
  Pages: 1340-1345
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616009
[Journal Article] The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 12004
- Author(s)
  Sakata Y, Arima K, Takai T, Sakurai W, Masumoto K, Yuyama N, Suminami Y, Kishi F, Yamashita T, Kato T, Ogawa H, Fujimoto K, Matsuo Y, Sugita Y, Izuhara K.
- Journal Title
  
  J Biol Chem 279
  
  Pages: 5081-5087
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616009
[Journal Article] Dilution-method to refold bacterially expressed recombinant Der f 2 and Der p 2 to exhibit the secondary structure and histamine-releasing activity of natural allergens.
- Author(s)
  Toshiro Takai
- Journal Title
  
  Int Arch Allergy Immunol (印刷中)
- Data Source
  KAKENHI-PROJECT-16616009
[Journal Article] 表皮ケラチノサイトにおけるTSLP産生誘導
- Author(s)
  高井敏朗
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: (印刷中)
- NAID
  40018789102
- Data Source
  KAKENHI-PROJECT-22591251
[Patent] ダニグループ1アレルゲンの改変体2005
- Inventor(s)
  高井敏朗
- Industrial Property Rights Holder
  高井敏朗
- Industrial Property Number
  2004-192972
- Filing Date
  2005-06-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16616009
[Presentation] A new SDS-inducible irritant CD model shows H1 antihistamine-refractory itch and upregulated gene expression of IL-4 and Th17/Th22 cytokines2022
- Author(s)
  Kimitsu T, Takai T, Kamijo S, Masutani Y, Yoshimura T, Ichikawa S, Shimizu S, Ogawa T, Takada K, Tominaga M, Suto H, Takamori K, Ogawa H, Okumura K, Ikeda S
- Organizer
  日本研究皮膚科学会　第47回年次学術大会・総会
- Data Source
  KAKENHI-PROJECT-22K08529
[Presentation] シンポジウム10アレルギー疾患における上皮バリア異常の意義: 抗原のプロテアーゼ活性による炎症・感作の促進2022
- Author(s)
  高井敏朗, 上條清嗣, 池田志斈, 奥村康
- Organizer
  第71回日本アレルギー学会
- Invited
- Data Source
  KAKENHI-PROJECT-22K08529
[Presentation] シンポジウム2 食品アレルゲンのセンシング:アレルゲンの特性と感作・脱感作：アレルゲンのプロテアーゼ活性による炎症・感作の促進2022
- Author(s)
  高井敏朗
- Organizer
  第18回日本食品免疫学会
- Invited
- Data Source
  KAKENHI-PROJECT-22K08529
[Presentation] アレルゲンの基礎：抗原から免疫学まで2022
- Author(s)
  高井敏朗
- Organizer
  第25回お茶の水眼アレルギー研究会
- Invited
- Data Source
  KAKENHI-PROJECT-22K08529
[Presentation] Skin treatment with detergent induces dermatitis with H1 antihistamine-refractory itch and upregulates IL-4 and Th17/Th22 cytokine gene expression in C57BL/6 mice2022
- Author(s)
  Kamijo S, Masutani Y, Kimitsu T, Yoshimura T, Ichikawa S, Ogawa T, Tominaga M, Suto H, Takamori K, Ikeda S, Okumura K, Takai T
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08529
[Presentation] 持続的痒みを伴うプロテアーゼ抗原経皮感作・皮膚炎症の新規モデル2022
- Author(s)
  吉村智子, 上條清嗣, 木蜜徹, 舛谷友里恵, 高田佳子, 小川尊資, 小川秀興, 池田志斈, 奧村康, 高井敏朗
- Organizer
  第71回日本アレルギー学会
- Data Source
  KAKENHI-PROJECT-22K08529
[Presentation] H1受容体拮抗薬抵抗性の掻痒を伴う界面活性剤誘発皮膚炎モデル2022
- Author(s)
  木蜜徹，上條清嗣，舛谷友里恵, 吉村智子，髙田佳子，小川尊資，冨永光俊，髙森建二，小川秀興，池田志斈，奧村康，高井敏朗
- Organizer
  第71回日本アレルギー学会
- Data Source
  KAKENHI-PROJECT-22K08529
[Presentation] アレルゲンの基礎~抗原から免疫学まで~2021
- Author(s)
  高井敏朗
- Organizer
  第７回総合アレルギー講習会(日本アレルギー学会主催）
- Data Source
  KAKENHI-PROJECT-18K08417
[Presentation] Innate IL-17A Enhances IL-33-Independent Skin Eosinophilia and IgE Response on Subcutaneous Papain Sensitization2021
- Author(s)
  Seiji Kamijo, Mutsuko Hara, Mayu Suzuki, Susumu Nakae, Hideoki Ogawa, Ko Okumura, Toshiro Takai
- Organizer
  第70回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-18K08417
[Presentation] An enhancing role of innate IL-17A on IL-33-independent skin eosinophilia and IgE response in a subcutaneous papain sensitization model2021
- Author(s)
  Seiji Kamijo, Susumu Nakae, Ko Okumura, Toshiro Takai.
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08417
[Presentation] New epicutaneous sensitization model to protease antigen: itch-associated skin inflammation, a variety of Th subsets and IgE2021
- Author(s)
  Tomoko Yoshimura, Toshiro Takai, Seiji Kamijo,Toru Kimitsu, Yurie Masutani,Takasuke Ogawa, Ko Okumura, Hideoki Ogawa, Shigaku Ikeda
- Organizer
  第46回日本研究皮膚科学会年次学術大会
- Data Source
  KAKENHI-PROJECT-18K08417
[Presentation] プロテアーゼ抗原経皮投与による気道炎症予防：抗原修飾によるTh17誘導能消去2021
- Author(s)
  木蜜徹, 上條清嗣, 国峯真也, 舛谷友里恵, 吉村智子, 小川秀興, 池田志斈, 奧村康, 高井敏朗
- Organizer
  第70回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-18K08417
[Presentation] Detergent-induced skin inflammation and itch in a mast cell-independent and antihistamine-resistant manner in C57BL/6 mice2021
- Author(s)
  Yurie Masutani, Toshiro Takai, Seiji Kamijo,Toru Kimitsu, Tomoko Yoshimura, Ko Okumura, Hideoki Ogawa, Shigaku Ikeda
- Organizer
  第46回日本研究皮膚科学会年次学術大会
- Data Source
  KAKENHI-PROJECT-18K08417
[Presentation] Epicutaneous vaccination with ovalbumin prevents airway IL-33-dependent antigen-specific Th2 differentiation in mice2020
- Author(s)
  Kimitsu K, Takai T, Kunimine S, Kamijo S, Maruyama N, Masutani Y, Yoshimura T, Suchiva P, Shimizu S, Okumura, Ogawa H, Ikeda S
- Organizer
  日本研究皮膚科学会
- Data Source
  KAKENHI-PROJECT-18K08417
[Presentation] Epicutaneous sensitization to protease allergen via detergent-treated skin promotes IgE production and skin inflammation2020
- Author(s)
  Yoshimura T, Takai T, Ogawa T, Maruyama N, Yamanashi H, Kamijo S, Kimitsu T, Masutani Y, Okumura K, Ogawa H, Ikeda S
- Organizer
  日本研究皮膚科学会
- Data Source
  KAKENHI-PROJECT-18K08417
[Presentation] Inhibition of both COX-1 and -2 promotes epicutaneous sensitization to protease allergen and subsequent airway inflammation in mice2020
- Author(s)
  Masutani Y, Suchiva P, Takai T, Kamijo S, Maruyama N, Kimitsu T, Yoshimura T, Kunimine S, Shimizu S, Yokomizo T, Sugimoto Y, Okumura K, Ikeda S, Ogawa H
- Organizer
  日本研究皮膚科学会
- Data Source
  KAKENHI-PROJECT-18K08417
[Presentation] Cyclooxygenase inhibition in mice heightens adaptive- and innate-type responses against inhaled protease allergen and IL-332020
- Author(s)
  Kamijo S, Matsuno K, Harada N, Nakae S, Yokomizo T, Ogawa H, Ikeda S, Okumura K, Takai T
- Organizer
  JSA/WAO Joint Congress 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08417
[Presentation] Epicutaneous vaccination with protease allergen prevents airway inflammation induced by protease allergen inhalation in mice2020
- Author(s)
  Kunimine S, Takai T, Kamijo S, Maruyama N, Kimitsu T, Masutani, Y, Yoshimura T, Suchiva P, Shimizu S, Okumura K, Ogawa H, Ikeda S
- Organizer
  日本研究皮膚科学会
- Data Source
  KAKENHI-PROJECT-18K08417
[Presentation] Allergens as adjuvants: Epicutaneous sensitization to protease allergen and subsequent airway inflammation in murine models2019
- Author(s)
  Takai T
- Organizer
  Chinese Pediatric Society
- Invited
- Data Source
  KAKENHI-PROJECT-18K08417
[Presentation] Epicutaneous allergen vaccination prevents protease- and IL-33-mediated airway allergen sensitization2019
- Author(s)
  Kunimine S, Takai T, Kamijo S, Maruyama N, Suchiva P, Ogawa H, Okumura K, Ikeda S
- Organizer
  日本研究皮膚科学会
- Data Source
  KAKENHI-PROJECT-18K08417
[Presentation] Cyclooxygenase inhibition in mice heightens adaptive- and innate-type responses against inhaled protease allergen and IL-332019
- Author(s)
  Kamijo S, Takai T, Matsuno K, Harada N, Nakae S, Yokomizo T, Ogawa H, Okumura K, Ikeda S
- Organizer
  日本免疫学会
- Data Source
  KAKENHI-PROJECT-18K08417
[Presentation] アレルゲンの基礎：抗原から免疫まで2019
- Author(s)
  高井敏朗
- Organizer
  総合アレルギー講習会（日本アレルギー学会主催）
- Invited
- Data Source
  KAKENHI-PROJECT-18K08417
[Presentation] Cyclooxygenase inhibitor promotes epicutaneous sensitization to protease allergen and subsequent airway Inflammation2019
- Author(s)
  Suchiva P, Takai T, Maruyama N, Kamijo S, Okumura K, Ikeda S, Ogawa H
- Organizer
  日本研究皮膚科学会
- Data Source
  KAKENHI-PROJECT-18K08417
[Presentation] NSAID promotes epicutaneous sensitization to protease allergen and subsequent airway eosinophilia2019
- Author(s)
  Suchiva P, Takai T, Maruyama N, Kamijo S, Ikeda S, Okumura K, Ogawa H
- Organizer
  日本アレルギー学会
- Data Source
  KAKENHI-PROJECT-18K08417
[Presentation] 皮膚の界面活性剤処理はテープストリッピングと異なる様式でプロテアーゼ抗原に対する経皮感作を促進する2018
- Author(s)
  高井敏朗、越智啓乃、清村咲子、丸山奈津子、西岡いずみ、上條清嗣、飯田秀雄、中江進、小川秀興、池田志斈、奧村康
- Organizer
  第67回日本アレルギー学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08417
[Presentation] Airway inflammation after epicutaneous sensitization requires protease activity of low-dose allergen inhalation2018
- Author(s)
  Kamijo S, Suchiva P, Ogawa H, Ikeda S, Okumura K, Takai T
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08417
[Presentation] アレルゲンはなぜアレルゲンになるのか2018
- Author(s)
  高井敏朗
- Organizer
  第49回日本職業・環境アレルギー学会総会・学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08417
[Presentation] Epicutaneous allergic sensitization by synergy between allergen protease-activity and mechanical skin barrier damage in mice2016
- Author(s)
  Takai T, Iida H, Shimura S, Ochi H, Maruyama N, Nishioka I, Kamijo S, Hara M, Saito H, Nakae S, Ogawa H, Ikeda S, Okumura K
- Organizer
  31th Symposium of the Collegium Internationale Allergologicum
- Place of Presentation
  Charleston, SC, USA
- Year and Date
  2016-04-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] Protease allergen and tape-stripping cooperatively promote epidermal barrier dysfunction and proinflammatory gene expression in mice2016
- Author(s)
  Suchiva P, Takai T, Maruyama N, Iida H, Shimura S, Ochi H, Kamijo S, Nishioka I, Okumura K, Ikeda S, Ogawa H
- Organizer
  日本研究皮膚科学会
- Place of Presentation
  仙台, 宮城
- Year and Date
  2016-12-09
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] Epicutaneous administration of protease allergen and mechanical skin barrier damage synergistically promote epidermal barrier dysfunction and proinflammatory gene expression toward allergic sensitization in mice2016
- Author(s)
  Suchiva P, Takai T, Maruyama N, Iida H, Shimura S, Ochi H, Kamijo S, Nishioka I, Okumura K, Ikeda S, Ogawa H
- Organizer
  The 4th Eastern Asia Dermatology Congress
- Place of Presentation
  浦安, 千葉
- Year and Date
  2016-11-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] ダニアレルゲンワクチン標準化に関する日本アレルギー学会タスクフォース報告2016
- Author(s)
  12. 高井敏朗, 岡本美孝, 大久保公裕, 永田真, 阪口雅弘, 福冨友馬, 齋藤明美, 安枝浩, 増山敬祐
- Organizer
  日本アレルギー学会
- Place of Presentation
  東京国際フォーラム、東京
- Year and Date
  2016-06-19
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] アレルゲン、LPSおよびサイトカイン刺激による好塩基球のIL-4 産生はFc受容体g鎖に依存する2016
- Author(s)
  上條清嗣, 布村聡, 羅智靖, 金口泰彦, 鈴木祐介, 小川秀興, 奥村康, 高井敏朗
- Organizer
  日本アレルギー学会
- Place of Presentation
  東京国際フォーラム、東京
- Year and Date
  2016-06-18
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] Allergens as adjuvants: barrier disruption and innate immunity2016
- Author(s)
  Takai T
- Organizer
  East Asia Allergy Symposium
- Place of Presentation
  Nanjing, China
- Year and Date
  2016-09-02
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] プロテアーゼ活性を有する抗原による経皮感作とアレルギー疾患2016
- Author(s)
  高井敏朗
- Organizer
  第21回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  千里ライフサイエンスセンター, 大阪
- Year and Date
  2016-08-05
- Invited
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] プロテアーゼアレルゲン皮下感作はIL-33非依存的・マスト細胞依存的に誘導される2016
- Author(s)
  7. 清村咲子、高井敏朗、上條清嗣、鈴木麻友、原むつ子、越智啓乃、丸山奈津子、松田彰、齋藤博久、中江進、市川さおり、小川秀興、奥村康、池田志斈
- Organizer
  日本接触性皮膚炎・皮膚アレルギー学会
- Place of Presentation
  京王プラザホテル、東京
- Year and Date
  2016-11-05
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] Skin IL-17A production from activated dendritic epidermal T cells contributes to enhancement of papaininduced allergic responses in the skin2016
- Author(s)
  Kamijo S, Nakae S, Ogawa H, Okumura K, Takai T
- Organizer
  日本免疫学会
- Place of Presentation
  沖縄
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] パパイン皮下投与感作マウスのアトピーマーチにおけるIL-33の関与2015
- Author(s)
  越智啓乃、高井敏朗、飯田秀雄、上條清嗣、清村咲子、西岡いずみ、丸山奈津子、奥村康、小川秀興、池田志斈
- Organizer
  日本皮膚科学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2015-05-29
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] プロテアーゼアレルゲンの経皮的投与による皮膚バリア機能障害および抗体産生誘導の検討2015
- Author(s)
  越智啓乃、高井敏朗、飯田秀雄、上條清嗣、清村咲子、西岡いずみ、丸山奈津子、奥村康、小川秀興、池田志斈
- Organizer
  日本皮膚アレルギー・接触性皮膚炎学会
- Place of Presentation
  島根県民会館（島根県松江市）
- Year and Date
  2015-11-20
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] Epicutaneous allergic sensitization by synergy between allergen protease-activity and mechanical skin barrier damage in mice2015
- Author(s)
  Takai T, Nishioka I, Iida H, Shimura S, Ochi H, Maruyama N, Okumura K, Ogawa H, Ikeda S
- Organizer
  表皮細胞研究会
- Place of Presentation
  ホテルニューオータニ佐賀（佐賀県佐賀市）
- Year and Date
  2015-11-14
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] アレルゲンの生物活性とアジュバント作用：なぜアレルゲンになるのか2015
- Author(s)
  高井敏朗
- Organizer
  日本眼薬理学会
- Place of Presentation
  ソラシティカンファレンスセンター（東京都千代田区）
- Year and Date
  2015-09-06
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] Murine models of epicutaneous sensitization to protease allergen, which leads to allergic airway inflammation upon subsequent airway challenge2015
- Author(s)
  Shimura S, Takai T, Iida H, Kamijo S, Ochi H, Maruyama N, Nishioka I, Suchiva P, Matsuda A, Saito H, Nakae S, Ogawa H, Okumura K, Ikeda S
- Organizer
  日本研究皮膚科学会
- Place of Presentation
  岡山コンベンションセンター（岡山県岡山市）
- Year and Date
  2015-12-11
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] Subcutaneous allergic sensitization to protease allergen is dependent on mast cells but not IL-33: Distinct mechanisms between subcutaneous and intranasal routes2015
- Author(s)
  Kamijo S, Takai T, Hara M, Matsuda H, Matsuda A, Saito H, Nakae S, Ichikawa S, Ogawa H, Okumura K
- Organizer
  日本免疫学会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] シンポジウム18: アレルギー疾患とマウスモデル. マウスモデルを用いたアレルゲンの生物活性の解析2015
- Author(s)
  高井敏朗、上條清嗣、小川秀興、池田志斈、奧村康
- Organizer
  日本アレルギー学会
- Place of Presentation
  グランドプリンスホテル新高輪（東京都港区）
- Year and Date
  2015-05-26
- Invited
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] パパインの経皮感作マウスモデルによるプロテアーゼ活性依存的な特異的抗体産生誘導2015
- Author(s)
  西岡いずみ、高井敏朗、飯田秀雄、上條清嗣、清村咲子、越智啓乃、丸山奈津子、奥村康、小川秀興、池田志斈
- Organizer
  日本皮膚科学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2015-05-29
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] プロテアーゼ抗原塗布とテープストリッピングはIL-33非依存的に皮膚炎症および抗体産生を促進する2015
- Author(s)
  清村咲子、高井敏朗、飯田秀雄、上條清嗣、越智啓乃、丸山奈津子、西岡いづみ、齋藤博久、中江進、小川秀興、池田志斈、奥村康
- Organizer
  日本アレルギー学会
- Place of Presentation
  グランドプリンスホテル新高輪（東京都港区）
- Year and Date
  2015-05-26
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] アレルギー疾患の修飾因子：1. アレルゲンとその修飾因子2015
- Author(s)
  高井敏朗
- Organizer
  第２回総合アレルギー講習会(日本アレルギー学会)
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2015-04-12
- Invited
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] Subcutaneous presentitization to protease antigen and IL-33-dependent airway responses cooperatively contribute to airway inflammation2015
- Author(s)
  Ochi H, Takai T, Kamijo S, Shimura S, Maruyama N, Matsuda A, Saito H, Nakae S, Okumura K, Ogawa H, Ikeda
- Organizer
  日本研究皮膚科学会
- Place of Presentation
  岡山コンベンションセンター（岡山県岡山市）
- Year and Date
  2015-12-11
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] アレルゲンが引き起こすバリア破壊と自然免疫応答2015
- Author(s)
  高井敏朗
- Organizer
  ABCの会
- Place of Presentation
  ホテルニューオータニ、東京
- Year and Date
  2015-01-23
- Invited
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] アレルギー疾患の修飾因子 1. アレルゲンとその修飾因子2014
- Author(s)
  高井敏朗
- Organizer
  日本アレルギー学会　第1回総合アレルギー講習会
- Place of Presentation
  パシフィコ横浜、神奈川
- Year and Date
  2014-12-20
- Invited
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] Contribution of adaptive immune cells and IL-33-mediated innate response to protease allergen-dependent allergic airway inflammation2013
- Author(s)
  Toshiro Takai
- Organizer
  Keystone Symposia on Molecular and Cellular Biology, Type 2 immunity: initiation, maintenance, homeostasis and pathology
- Place of Presentation
  Santa Fe, New Mexico, USA
- Data Source
  KAKENHI-PROJECT-22591251
[Presentation] IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation2013
- Author(s)
  Toshiro Takai
- Organizer
  15th International Congress of Immunology
- Place of Presentation
  Milano, Italy
- Data Source
  KAKENHI-PROJECT-22591251
[Presentation] IL-33 does not contribute to subcutaneous sensitization to cysteine protease allergen but contributes to allergic airway inflammation induced by subsequent intranasal challenge2013
- Author(s)
  Kamijo S, Takai T, Hara M, Matsuda H, Matsuda A, Saito H, Nakae S, Ichikawa S, Ogawa H, Okumura K
- Organizer
  日本免疫学会
- Place of Presentation
  幕張メッセ（千葉）
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] アレルゲンはなぜアレルゲンになるのか?:Th2/IgE誘導アジュバントとしてのアレルゲンおよび黄色ブドウ球菌2012
- Author(s)
  高井敏朗
- Organizer
  日本耳鼻咽喉アレルギー免疫学会
- Place of Presentation
  琵琶湖ホテル(滋賀県)(招請)
- Year and Date
  2012-02-16
- Data Source
  KAKENHI-PROJECT-22591251
[Presentation] Th2アジュバントとしてのアレルゲン：バリアと自然免疫系に対する作用2012
- Author(s)
  高井敏朗
- Organizer
  日本アレルギー学会春季臨床大会
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PROJECT-22591251
[Presentation] Symposium S3E-32. New frontiers in molecular mechanisms of allergic diseases. Allergens and their Th2 adjuvant activity2012
- Author(s)
  Toshiro Takai
- Organizer
  日本薬理学会
- Place of Presentation
  京都国際会館(京都府)(招請)
- Year and Date
  2012-03-16
- Data Source
  KAKENHI-PROJECT-22591251
[Presentation] アレルゲンの持つアジュバント作用と抗原感作機構2012
- Author(s)
  高井敏朗
- Organizer
  大阪皮膚アレルギーネットワーク(ODAN)
- Place of Presentation
  ANAクラウンプラザホテル大阪(大阪府)(招請)
- Year and Date
  2012-01-21
- Data Source
  KAKENHI-PROJECT-22591251
[Presentation] スギヒノキ花粉症患者鼻粘膜擦過細胞におけるフィラグリンの発現2012
- Author(s)
  三輪正人, 花尾麻美, 塩沢晃人, 廣津幹夫, 小野倫嗣, 池田勝久, 原むつ子, 高井敏朗, 奥村康
- Organizer
  日本アレルギー学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24592580
[Presentation] 教育講演1.アレルゲンとは何か:3つの顔2011
- Author(s)
  高井敏朗
- Organizer
  日本アレルギー学会
- Place of Presentation
  グランドプリンスホテル新高輪(東京都)(招請)
- Year and Date
  2011-11-10
- Data Source
  KAKENHI-PROJECT-22591251
[Presentation] アレルゲンを考える:アレルゲンはなぜアレルゲンになるのか?2011
- Author(s)
  高井敏朗
- Organizer
  那須ティーチイン
- Place of Presentation
  ホテルマリナーズコート東京(東京都)(招請)
- Year and Date
  2011-07-30
- Data Source
  KAKENHI-PROJECT-22591251
[Presentation] 「なぜアレルゲンはアレルゲンになるのか?」広義のTh2/IgE誘導アジュバントとしての環境アレルゲンおよび黄色ブドウ球菌2011
- Author(s)
  高井敏朗
- Organizer
  日本皮膚アレルギー学会
- Place of Presentation
  富士屋ホテル(山梨県)(招請)
- Year and Date
  2011-07-16
- Data Source
  KAKENHI-PROJECT-22591251
[Presentation] Staphylococcus aureus-derived extracellular protease and membranous TLR2-TLR6 ligand induce skin barrier dysfunction and production of TSLP2011
- Author(s)
  Toshiro Takai, et al
- Organizer
  日本免疫学会総会・学術集会
- Place of Presentation
  幕張メッセ(千葉県)
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-22591251
[Presentation] APAPARI Sympoium : Allergen. Environmental allergens and their Th2 adjuvant activity2011
- Author(s)
  Toshiro Takai
- Organizer
  Joint Congress of Asia Pacific Association of Pediatric Allergy, Respirology & Immunology 2011 (APAPARI 2011) and 48th Annual Meeting of Japanese Society of Pediatric Allergy and Clinical Immunology (48th JSPACI)
- Place of Presentation
  福岡国際会議場(福岡県)(招請)
- Year and Date
  2011-10-28
- Data Source
  KAKENHI-PROJECT-22591251
[Presentation] シンポジウム15.免疫細胞と組織構成細胞の接点.環境→Th2応答への橋渡し:TLRリガンドによる上皮からのTSLP産生誘導2011
- Author(s)
  高井敏朗
- Organizer
  日本アレルギー学会
- Place of Presentation
  グランドプリンスホテル新高輪(東京都)
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-22591251
[Presentation] Response of epidermis and epithelium against allergens, viral/microbial components, or endogenous factors : barrier disruption, proinflammatory responses, and homeostasis2010
- Author(s)
  Takai, Toshiro
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  Kobe, Japan
- Data Source
  KAKENHI-PROJECT-22591251
[Presentation] 教育講演:なぜアレルゲンはアレルゲンになるのか2010
- Author(s)
  高井敏朗
- Organizer
  日本アレルギー学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22591251
[Presentation] プロテアーゼアレルゲンによる経皮的感作はプロテアーゼ活性依存的にIgE/IgG産生を誘導する
- Author(s)
  清村咲子、高井敏朗、飯田秀雄、上條清嗣、越智啓乃、丸山奈津子、原むつ子、小川秀興、池田志斈
- Organizer
  日本アレルギー学会
- Place of Presentation
  京都国際会館、京都
- Year and Date
  2014-05-09 – 2014-05-11
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] プロテアーゼアレルゲンの経皮的投与による皮膚バリア機能低下および抗体産生誘導の検討
- Author(s)
  西岡いずみ、高井敏朗、飯田秀雄、上條清嗣、清村咲子、越智啓乃、丸山奈津子、原むつ子、奥村康、小川秀興、池田志斈
- Organizer
  第44回日本皮膚アレルギー・接触皮膚炎学会総会・学術大会
- Place of Presentation
  仙台国際センター、宮城
- Year and Date
  2014-11-21 – 2014-11-23
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] Distinct mechanisms for allergic sensitization to protease antigen between skin and airway
- Author(s)
  Takai T, Kamijo S, Saito H, Nakae S, Ogawa H, Okumura K
- Organizer
  0th Symposium of the Collegium Internationale Allergologicum (CIA)
- Place of Presentation
  Petersberg, Germany
- Year and Date
  2014-09-12 – 2014-09-18
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] Subcutaneous presensitization to protease antigen enhances protease-induced allergic airway inflammation
- Author(s)
  Hirono Ochi, Toshiro Takai, Seiji Kamijo, Sakiko Shimura, Natsuko Maruyama, Ko Okumura, Hideoki Ogawa, Shigaku Ikeda
- Organizer
  日本研究皮膚科学会第39回年次学術大会・総会
- Place of Presentation
  阪急エキスポパーク、大阪
- Year and Date
  2014-12-12 – 2014-12-14
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] アレルゲンの持つアジュバント作用と抗原感作機構
- Author(s)
  高井敏朗
- Organizer
  茨城県小児アレルギー研究会
- Place of Presentation
  つくば
- Invited
- Data Source
  KAKENHI-PROJECT-22591251
[Presentation] シンポジウム３：アレルギーにおける自然免疫応答．プロテアーゼアレルゲンによるIgE産生と気道炎症の誘導
- Author(s)
  上條清嗣、高井敏朗、中江進、齋藤博久、奧村康
- Organizer
  日本アレルギー学会
- Place of Presentation
  国立京都国際会館（京都）
- Invited
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] プロテアーゼ抗原塗布とテープストリッピングはIL-33非依存的に皮膚炎症および抗体産生を促進する
- Author(s)
  清村咲子、高井敏朗、飯田秀雄、上條清嗣、越智啓乃、丸山奈津子、西岡いづみ、齋藤博久、中江進、小川秀興、池田志斈、奥村康
- Organizer
  日本アレルギー学会
- Place of Presentation
  グランドプリンスホテル新高輪、東京
- Year and Date
  2015-05-26 – 2015-05-28
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] TSLPおよびIL-33の産生誘導とアレルギー
- Author(s)
  高井敏朗
- Organizer
  喘息治療セミナー21（ロイコトリエン研究会）
- Place of Presentation
  名古屋
- Invited
- Data Source
  KAKENHI-PROJECT-22591251
[Presentation] パパインの経皮感作マウスモデルによるプロテアーゼ活性依存的な特異的抗体産生誘導
- Author(s)
  西岡いずみ、高井敏朗、飯田秀雄、上條清嗣、清村咲子、越智啓乃、丸山奈津子、奥村康、小川秀興、池田志斈
- Organizer
  日本皮膚科学会
- Place of Presentation
  パシフィコ横浜、神奈川
- Year and Date
  2015-05-29 – 2015-05-31
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] アレルゲン研究の最前線
- Author(s)
  高井敏朗
- Organizer
  関東耳鼻咽喉科アレルギー懇話会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-22591251
[Presentation] パパイン皮下投与感作マウスのアトピーマーチにおけるIL-33の関与
- Author(s)
  越智啓乃、高井敏朗、飯田秀雄、上條清嗣、清村咲子、西岡いずみ、丸山奈津子、奥村康、小川秀興、池田志斈
- Organizer
  日本皮膚科学会
- Place of Presentation
  パシフィコ横浜、神奈川
- Year and Date
  2015-05-29 – 2015-05-31
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] プロテアーゼアレルゲンによる経皮的感作はプロテアーゼ活性依存的にIgE/IgG産生を誘導する
- Author(s)
  清村咲子、高井敏朗、飯田秀雄、上條清嗣、越智啓乃、丸山奈津子、原むつ子、小川秀興、池田志斈、奧村康
- Organizer
  日本アレルギー学会
- Place of Presentation
  国立京都国際会館（京都）
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] アレルゲンの持つアジュバント作用と抗原感作機構
- Author(s)
  高井敏朗
- Organizer
  第10回九州耳鼻科薬物治療研究会
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-22591251
[Presentation] シンポジウム３：アレルギーにおける自然免疫応答．プロテアーゼアレルゲンによるIgE産生と気道炎症の誘導
- Author(s)
  上條清嗣、高井敏朗、中江進、齋藤博久、奧村康
- Organizer
  日本アレルギー学会
- Place of Presentation
  京都国際会館、京都
- Year and Date
  2014-05-09 – 2014-05-11
- Invited
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] シンポジウム18: アレルギー疾患とマウスモデル. マウスモデルを用いたアレルゲンの生物活性の解析
- Author(s)
  高井敏朗、上條清嗣、小川秀興、池田志斈、奧村康
- Organizer
  日本アレルギー学会
- Place of Presentation
  グランドプリンスホテル新高輪、東京
- Year and Date
  2015-05-26 – 2015-05-28
- Invited
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] The role of protease allergens in the establishment of epicutaneous sensitization
- Author(s)
  Sakiko Shimura, Toshiro Takai, Hideo Iida, Yusuke Hirasawa, Seiji Kamijo, Hirono Ochi, Izumi Nishioka, Natsuko Maruyama, Mutsuko Hara, Ko Okumura, Hideoki Ogawa, Shigaku Ikeda
- Organizer
  日本研究皮膚科学会第39回年次学術大会・総会
- Place of Presentation
  阪急エキスポパーク、大阪
- Year and Date
  2014-12-12 – 2014-12-14
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] アレルギー診療に役立つ免疫講座１．アレルゲンが引き起こすバリア破壊と自然免疫応答
- Author(s)
  高井敏朗
- Organizer
  日本アレルギー学会
- Place of Presentation
  京都国際会館、京都
- Year and Date
  2014-05-09 – 2014-05-11
- Invited
- Data Source
  KAKENHI-PROJECT-25461711
[Presentation] アレルギー診療に役立つ免疫講座１．アレルゲンが引き起こすバリア破壊と自然免疫応答
- Author(s)
  高井敏朗
- Organizer
  日本アレルギー学会
- Place of Presentation
  国立京都国際会館（京都）
- Invited
- Data Source
  KAKENHI-PROJECT-25461711

1. MIWA Masato (80247650)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. KAMIYA Kazusaku (10374159)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. IKEDA Katsuhisa (70159614)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. KAMIJOU Seiji

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. HARADA Norihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. TAKESHIGE tomohito

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. HARADA sonoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. MATSUNO kei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. SAITO Hirohisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. NAKAE Susumu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 須藤一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 奥村康

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 杉本幸彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 伊藤潤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takai Toshiro 高井 敏朗

TAKAI Toshiro 高井 敏朗

Research Projects

Research Products

Co-Researchers

Interplay among barrier, immunity and itch in epicutaneous allergen sensitizationPrincipal Investigator

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Analysis of inflammation and sensitization on epicutaneous antigen exposurePrincipal Investigator

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Roles of protease allergen in epicutaneous sensitizationPrincipal Investigator

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Molecular mechanism of barrier function in human nasal mucosal epithelia

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Induction of TSLP by environmental and self factors associated with atopic dermatitisPrincipal Investigator

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ANALYSIS OF IGE-SENSITIZATION DEPENDENT ON CYSTEINE PROTEASE ACTIVITY OF MITE MAJOR ALLERGENSPrincipal Investigator

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ダニアレルゲン蛋白質の高次構造に焦点をあてたIgEエピトープ解析及びワクチン設計Principal Investigator

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[Book] Methods in Enzymology: Endosomal Signaling: TSLP expression induced via Toll-like receptor pathways in human keratinocytes2013

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[Book] Handbook of Proteolytic Enzymes: Serine endopeptidase allergens from Dermatophagoides species2013

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[Book] Mite endopeptidase 1. In: Neil D. Rawlings and Guy S2013

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[Book] Serine endopeptidase allergens from Dermatophagoidesspecies. In: Neil D. Rawlings and Guy S2013

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[Book] Handbook of Proteolytic Enzymes: Mite endopeptidase 12013

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[Book] 先端医療シリーズ38皮膚疾患の最新医療2006

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[Journal Article] Antigen protease activity with a detergent induces severe skin inflammation with itch and robust Th17/Th22 differentiation in mice2023

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[Journal Article] Skin Treatment with Detergent Induces Dermatitis with H1-Antihistamine-Refractory Itch and Upregulates IL-4 and Th17/Th22 Cytokine Gene Expression in C57BL/6 Mice2022

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Takai Toshiro 高井敏朗

TAKAI Toshiro 高井敏朗

[Journal Article] 2 病態の新しい考え方　7) ダニの関与2019