Shirai Yoshinori 白井良憲

… Alternative Names

白井良憲シライヨシノリ

SHIRAI Yoshinori 白井良憲

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Researcher Number	70342798
Other IDs
Affiliation (Current)	2025: 信州大学, 学術研究院医学系, 助教
Affiliation (based on the past Project Information) *help	2023 – 2024: 信州大学, 学術研究院医学系, 助教 2015 – 2017: 信州大学, 学術研究院医学系, 助教 2011 – 2013: 信州大学, 医学系研究科, 助教
Review Section/Research Field	Principal Investigator Neurochemistry/Neuropharmacology Except Principal Investigator Basic Section 46010:Neuroscience-general-related / Neurochemistry/Neuropharmacology
Keywords	Principal Investigator 非翻訳領域 / 核タンパク質 / シナプス可塑性 / 遺伝子発現 / 核移行 / 局所翻訳 / mRNA Except Principal Investigator シナプス / CASK異常症 / 発達障害 … More / 小脳低形成 / JNK阻害剤 / X染色体不活性化 / MICPCH症候群 / CASK / in situ hybridization / synapse / RNA-binding protein / local translation / dendrite / Gtf2i / mRNA / transcription factor / synaptic plasticity / splice variants / local protein synthesis / postsynaptic density Less

X連鎖性マウス遺伝学を利用したMICPCH症候群の神経病態メカニズムの解明
- Principal Investigator
  
  田渕克彦
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Shinshu University
Analyses for synapse-nuclear signaling via a PSD-localizing transcription factor
- Principal Investigator
  
  Suzuki Tatsuo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Shinshu University
Local translation of nuclear proteins at the synapses, translocation to the nucleus and synaptic plasticity.Principal Investigator
- Principal Investigator
  
  SHIRAI Yoshinori
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Shinshu University

All 2025 2024 2023 2018 2017 2016 2015 2013 Other

All Journal Article Presentation Patent

[Journal Article] Jun N-Terminal Kinase Inhibitor Suppresses CASK Deficiency-Induced Cerebellar Granular Cell Death in MICPCH Syndrome Model Mice2025
- Author(s)
  Qi Guo, Emi Kouyama-Suzuki, Yoshinori Shirai and Katsuhiko Tabuchi
- Journal Title
  
  Cells
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27266
[Journal Article] The Competitive Loss of Cerebellar Granule and Purkinje Cells Driven by X-Linked Mosaicism in a Female Mouse Model of CASK-Related Disorders2025
- Author(s)
  Takuma Mori, Mengyun Zhou, Ken Kunugitani, Taichi Akatsuka, Yukina Yoshida, Emi Kouyama-Suzuki, Shin Kobayashi, Yoshinori Shirai, Katsuhiko Tabuchi
- Journal Title
  
  Cells
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27266
[Journal Article] Deep-Learning-Based Analysis Reveals a Social Behavior Deficit in Mice Exposed Prenatally to Nicotine2024
- Author(s)
  Zhou Mengyun、Qiu Wen、Ohashi Nobuhiko、Sun Lihao、Wronski Marie-Louis、Kouyama-Suzuki Emi、Shirai Yoshinori、Yanagawa Toru、Mori Takuma、Tabuchi Katsuhiko
- Journal Title
  
  Cells
  
  Volume: 13 Issue: 3 Pages: 275-275
- DOI
  10.3390/cells13030275
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07293, KAKENHI-PUBLICLY-23H04227, KAKENHI-PROJECT-23K27266, KAKENHI-PROJECT-23K24516
[Journal Article] Structural Analysis Implicates CASK-Liprin-α2 Interaction in Cerebellar Granular Cell Death in MICPCH Syndrome2023
- Author(s)
  Guo Qi、Kouyama-Suzuki Emi、Shirai Yoshinori、Cao Xueshan、Yanagawa Toru、Mori Takuma、Tabuchi Katsuhiko
- Journal Title
  
  Cells
  
  Volume: 12 Issue: 8 Pages: 1177-1177
- DOI
  10.3390/cells12081177
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H05686, KAKENHI-PROJECT-19H03544, KAKENHI-PROJECT-23K27266
[Journal Article] Role of Splice Variants of Gtf2i, a Transcription Factor Localizing at Postsynaptic Sites, and Its Relation to Neuropsychiatric Diseases2017
- Author(s)
  Shirai Yoshinori、Li Weidong、Suzuki Tatsuo
- Journal Title
  
  Int J Mol Sci
  
  Volume: 18 Issue: 2 Pages: 411-411
- DOI
  10.3390/ijms18020411
- NAID
  120007099803
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06771
[Journal Article] Novel splice variants in the 5’UTR of Gtf2i expressed in the rat brain: alternative 5’UTRs and differential expression in the neuronal dendrites.2015
- Author(s)
  Yoshinori Shirai, Masahiko Watanabe, Hiroyuki Sakagami and Tatsuo Suzuki
- Journal Title
  
  J. Neurochemistry
  
  Volume: 134 Issue: 3 Pages: 578-589
- DOI
  10.1111/jnc.13136
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06771, KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-24220007, KAKENHI-PROJECT-15H04672
[Patent] CASK DISORDER TREATING AGENT AND TREATMENT METHOD2024
- Inventor(s)
  田渕克彦、白井良憲法、森琢磨、鈴木絵美
- Industrial Property Rights Holder
  田渕克彦、白井良憲法、森琢磨、鈴木絵美
- Industrial Property Rights Type
  特許
- Filing Date
  2024
- Overseas
- Data Source
  KAKENHI-PROJECT-23K27266
[Patent] JNK阻害剤によるMICPCH症候群の小脳変性の抑制効果の発見2023
- Inventor(s)
  田渕克彦、白井良憲、森琢磨、鈴木絵美
- Industrial Property Rights Holder
  田渕克彦、白井良憲、森琢磨、鈴木絵美
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-23K27266
[Presentation] 精神疾患関連遺伝子Gtf2i mRNAの5’UTRおよびRNA結合タンパク質Pur αによる神経細胞樹状突起での局所翻訳調節2018
- Author(s)
  白井良憲，李衛東, 田渕克彦, 鈴木龍雄
- Organizer
  第41回日本神経科学学会
- Data Source
  KAKENHI-PROJECT-15K06771
[Presentation] 精神疾患関連遺伝子Gtf2i mRNAの5’UTR依存的な神経細胞樹状突起への局在と5’UTR特異的なRNA結合タンパク質の同定2017
- Author(s)
  白井良憲，鈴木龍雄
- Organizer
  第40回日本神経科学学会
- Data Source
  KAKENHI-PROJECT-15K06771
[Presentation] PSDに付随するASD関連遺伝子Rai1 mRNA： alternative 5´UTRs、mRNAの樹状突起への局在とRNA結合タンパク質2016
- Author(s)
  Yoshinori Shirai and Tatsuo Suzuki
- Organizer
  第39回日本神経科学学会
- Place of Presentation
  横浜，パシフィコ横浜
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-15K06771
[Presentation] Novel splice variants of gtf2i expressed in the neuronal dendrites of rat brain2016
- Author(s)
  Yoshinori Shirai and Tatsuo Suzuki
- Organizer
  Society for Neuroscience Meeting
- Place of Presentation
  San Diego, 米国
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06771
[Presentation] PSDに局在するASD関連遺伝子mRNAのalternative 5’UTRsと脳での発現2015
- Author(s)
  Yoshinori Shirai, Tatsuo Suzuki
- Organizer
  第38回日本神経科学学会
- Place of Presentation
  神戸国際会議場 (兵庫県神戸市)
- Year and Date
  2015-07-30
- Data Source
  KAKENHI-PROJECT-15K06771
[Presentation] CAGE データベースを用いた Gtf2i の新規な 5' UTR の同定および脳での発現2013
- Author(s)
  白井良憲・鈴木龍雄
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2013-12-03
- Data Source
  KAKENHI-PROJECT-23650189
[Presentation] CAGEデータベースを用いたGtf2iの新規な5'UTRsの同定および脳での発現
- Author(s)
  白井良憲、鈴木龍雄
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-23650189

1. SUZUKI Tatsuo (80162965)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 田渕克彦 (20546767)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 森琢磨 (70545798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. Li Weidong

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 鈴木龍男

# of Collaborated Projects: 0 results

# of Collaborated Products: 9 results

Shirai Yoshinori 白井 良憲

白井 良憲 シライ ヨシノリ

SHIRAI Yoshinori 白井 良憲

Research Projects

Research Products

Co-Researchers

X連鎖性マウス遺伝学を利用したMICPCH症候群の神経病態メカニズムの解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analyses for synapse-nuclear signaling via a PSD-localizing transcription factor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Local translation of nuclear proteins at the synapses, translocation to the nucleus and synaptic plasticity.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Jun N-Terminal Kinase Inhibitor Suppresses CASK Deficiency-Induced Cerebellar Granular Cell Death in MICPCH Syndrome Model Mice2025

Author(s)

Journal Title

Data Source

[Journal Article] The Competitive Loss of Cerebellar Granule and Purkinje Cells Driven by X-Linked Mosaicism in a Female Mouse Model of CASK-Related Disorders2025

Author(s)

Journal Title

Data Source

[Journal Article] Deep-Learning-Based Analysis Reveals a Social Behavior Deficit in Mice Exposed Prenatally to Nicotine2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural Analysis Implicates CASK-Liprin-α2 Interaction in Cerebellar Granular Cell Death in MICPCH Syndrome2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of Splice Variants of Gtf2i, a Transcription Factor Localizing at Postsynaptic Sites, and Its Relation to Neuropsychiatric Diseases2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Novel splice variants in the 5’UTR of Gtf2i expressed in the rat brain: alternative 5’UTRs and differential expression in the neuronal dendrites.2015

Author(s)

Journal Title

DOI

Data Source

[Patent] CASK DISORDER TREATING AGENT AND TREATMENT METHOD2024

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] JNK阻害剤によるMICPCH症候群の小脳変性の抑制効果の発見2023

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Presentation] 精神疾患関連遺伝子Gtf2i mRNAの5’UTRおよびRNA結合タンパク質Pur αによる神経細胞樹状突起での局所翻訳調節2018

Author(s)

Organizer

Data Source

[Presentation] 精神疾患関連遺伝子Gtf2i mRNAの5’UTR依存的な神経細胞樹状突起への局在と5’UTR特異的なRNA結合タンパク質の同定2017

Author(s)

Organizer

Data Source

[Presentation] PSDに付随するASD関連遺伝子Rai1 mRNA： alternative 5´UTRs、mRNAの樹状突起への局在とRNA結合タンパク質2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Novel splice variants of gtf2i expressed in the neuronal dendrites of rat brain2016

Shirai Yoshinori 白井良憲

白井良憲シライヨシノリ

SHIRAI Yoshinori 白井良憲