KUME Shoen 粂昭苑

Researcher Number	70347011
Other IDs
External Links
Affiliation (Current)	2025: 東京科学大学, 生命理工学院, 教授
Affiliation (based on the past Project Information) *help	2016 – 2024: 東京工業大学, 生命理工学院, 教授 2014 – 2015: 東京工業大学, 大学院生命理工学研究科, 教授 2014: 東京工業大学, 生命理工学研究科, 教授 2014: 熊本大学, 発生医学研究所, 教授 2011: Kumamoto University, 教授 2009 – 2011: Kumamoto University, 発生医学研究所, 教授 2003 – 2007: 熊本大学, 発生医学研究センター, 教授
Review Section/Research Field	Principal Investigator Biological Sciences / Basic Section 54040:Metabolism and endocrinology-related / Metabolomics / Gastroenterology / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields Except Principal Investigator Biomedical engineering/Biomaterial science and engineering / Neuroscience in general / Gastroenterology / Neurology / Metabolomics / Developmental biology
Keywords	Principal Investigator 膵臓 / 分化誘導 / 多能性幹細胞 / 再生医学 / インスリン / 内胚葉 / β細胞 / pdx1 / 内胚葉誘導 / 試験管内分化誘導 … More / 内分泌細胞 / インスリン分泌 / 膵臓β細胞 / ドパミン / 糖尿病 / 増殖 / 分化 / Pdx1 / 幹細胞 / 遺伝子強制発現 / 胚幹性細胞 / 胚性幹細胞 / 内分泌 / 糖感受性インスリン分泌 / 機能維持 / 膵臓内分泌細胞 / 代謝 / ES細胞 / 脱分化 / 機能制御 / 遺伝子発現 / ヘテロ性 / 内分泌β細胞 / 分泌 / 恒常性維持 / 膵臓分化 / 糖代謝 / 血糖維持 / VMAT2 / 膵β細胞 / 化合物 / モノアミン / 再生医療 / 腸前駆細胞 / 腸細胞 / 腸上皮細胞 / 肝細胞 / 消化管 / ニワトリ / 消火器形成 / ゲノムワイド / 誘導シグナル / 前駆細胞 / 運命追跡 / 移植 / 遺伝子発現プロファイル / 再生 / FoxA2 / シグナル源 / pdx 1 / 遺伝子プロファイリング … More Except Principal Investigator iPS細胞 / β細胞 / 内胚葉 / 人工臓器 / 糖尿病 / バイオ人工膵臓 / バイオ人工臓器 / 免疫隔離膜 / 細胞移植デバイス / circadian rhythm / biological clock / longevity / dopamine / insomnia / sleep / chronobiology / Drosophila / 概日周期 / 生物時計 / 寿命 / ドーパミン / 不眠 / 睡眠 / 時間生物学 / ショウジョウバエ / 肝細胞分化誘導法 / ケミカルスクリーニング / 肝細胞成熟化 / iPS細胞由来肝細胞 / 移植 / 線維芽細胞 / 肝細胞 / 遺伝子治療 / FAP / アミロイドーシス / 肝細胞置換療法 / 点変異修復 / トランスサイレチン / 家族性アミロイドポリニューロパチー / 中胚葉 / アミラーゼ / インスリン / DiI / ニワトリ / Pdx1 / ニワトリ胚 / insulin / 移植実験 / 細胞運命予定地図 / DiI 結晶 / 膵臓 / 分子基盤 / 再生 / 発生 / 消化器 Less

Generation of iPS-derived beta cells with heterogeneityPrincipal Investigator
- Principal Investigator
  
  粂昭苑
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Tokyo Institute of Technology
Improvement of functionality by heterogeneity formation of the iPS-derived pancreatic beta cellsPrincipal Investigator
- Principal Investigator
  
  Kume Shoen
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Tokyo Institute of Technology
Elucidation of the molecular mechanism regulating pancreatic islets using human pluripotent stem cell differentiation systemPrincipal Investigator
- Principal Investigator
  
  Kume Shoen
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Tokyo Institute of Technology
The mechanism for the maintenance of pancreatic beta cells derived by in vitro differentiation of human pluripotent stem cellsPrincipal Investigator
- Principal Investigator
  
  Kume Shoen
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Tokyo Institute of Technology
Research on innovative cell transplantation device using immunoisolation membrane
- Principal Investigator
  
  Ando Yusuke
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Prefectural University of Hiroshima
  Kyushu University
The purification and expansion of human iPS cell-derived intestinal precursor cells for future application in regenerative medicinePrincipal Investigator
- Principal Investigator
  
  Kume Shoen
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Institute of Technology
Identification of hepatic maturation mechanisms of human iPS cells by using chemical screening
- Principal Investigator
  
  YAMAZOE Taiji
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Gastroenterology
- Research Institution
  Kumamoto University
Generation of human iPS-derived pancreatic beta cells and its application towards regenerative medicinePrincipal Investigator
- Principal Investigator
  
  Kume Shoen
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Metabolomics
- Research Institution
  Tokyo Institute of Technology
Hepatocyte replacement therapy for familial amybidotic polyneuropathy combining iPS cells and gene-repair therapy
- Principal Investigator
  
  ANDO Yukio
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Kumamoto University
膵幹細胞の分化と維持の制御機構Principal Investigator
- Principal Investigator
  
  粂昭苑
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Kumamoto University
Analysis of the pancreas regionalization factor in the pre-pancreas region.
- Principal Investigator
  
  KATSUMOTO Keiichi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Kumamoto University
消化器の形態形成に関わる遺伝子の解析Principal Investigator
- Principal Investigator
  
  粂昭苑
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Kumamoto University
試験管内ES細胞分化誘導系を用いた膵幹細胞の解析Principal Investigator
- Principal Investigator
  
  粂昭苑
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
内胚葉系の発生・分化・再生の分子基盤
- Principal Investigator
  
  菊池裕
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Developmental biology
- Research Institution
  Nagoya University
ES細胞からの内胚葉細胞系譜制御遺伝子プロファイリング解析Principal Investigator
- Principal Investigator
  
  粂昭苑
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
ES細胞の試験管内分化系を用いた膵臓の発生分化の分子機構の解明Principal Investigator
- Principal Investigator
  
  粂昭苑
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
ES細胞からの内胚葉細胞系譜制御遺伝子プロファイリング解析Principal Investigator
- Principal Investigator
  
  粂昭苑
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
ES細胞から内胚葉系幹細胞への分化制御Principal Investigator
- Principal Investigator
  
  粂昭苑
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
Molecular Analysis of the sleep and arousal regulations and their relationship to the circadian rhythm using fruit fly, Drosophila melanogaster.
- Principal Investigator
  
  KUME Kazuhiko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  Kumamoto University

[Book] 新膵臓病学　第２章膵の発生2017
- Author(s)
  粂　昭苑
- Total Pages
  528
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-16K01362
[Book] 新膵臓病学第2章膵の発生2017
- Author(s)
  粂　昭苑
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-26253059
[Book] Stem Cell Therapy(The potential of ES cells and tissue stem cells in the regenerative medicine of type I diabetes)2010
- Author(s)
  Nobuaki Shiraki, Miki Rika, Keiichi Katsumoto, Shoen Kume
- Publisher
  Transworld Research(in press)
- Data Source
  KAKENHI-PROJECT-20790652
[Book] こころを育む脳の働き2005
- Author(s)
  粂和彦ら(共著)
- Total Pages
  271
- Publisher
  クバプロ
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300108
[Book] 時間の分子生物学2003
- Author(s)
  粂和彦
- Total Pages
  206
- Publisher
  講談社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300108
[Journal Article] Generation of induced pluripotent stem cell-derived beta-cells in blood amino acids-like medium.2023
- Author(s)
  Ali M, Kato Y, Shiraki N, Kume S
- Journal Title
  
  Biology Open
  
  Volume: 12 Issue: 3 Pages: 059581-059581
- DOI
  10.1242/bio.059581
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19543, KAKENHI-PROJECT-21H02978
[Journal Article] Activation of cAMP(EPAC2) signaling pathway promotes hepatocyte attachment.2023
- Author(s)
  Helena GA, Watanabe T, Kato Y, Shiraki N, Kume S.
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 12352-12352
- DOI
  10.1038/s41598-023-39712-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19543, KAKENHI-PROJECT-21H02978
[Journal Article] Selective proteasome degradation of C‐terminally‐truncated human WFS1 in pancreatic beta cells2023
- Author(s)
  Tokuma Hiraku、Sakano Daisuke、Tanabe Katsuya、Tanizawa Yukio、Shiraki Nobuaki、Kume Shoen
- Journal Title
  
  FEBS Open Bio
  
  Volume: 13 Issue: 8 Pages: 1405-1414
- DOI
  10.1002/2211-5463.13674
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K08011, KAKENHI-PROJECT-22K19543, KAKENHI-PROJECT-21H02978
[Journal Article] Transient Methionine Deprivation Triggers Histone Modification and Potentiates Differentiation of Induced Pluripotent Stem Cells.2023
- Author(s)
  Ozawa H, Kambe A, Hibi K, Murakami S, Oikawa A, Handa T, Fujiki K, Nakato R, Shirahige K, Kimura H, Shiraki N, Kume S
- Journal Title
  
  Stem Cells.
  
  Volume: 41(3) Issue: 3 Pages: 271-286
- DOI
  10.1093/stmcls/sxac082
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-20H05940, KAKENHI-PLANNED-18H05527, KAKENHI-PROJECT-22K19543, KAKENHI-PROJECT-20H05686, KAKENHI-PROJECT-21H02978
[Journal Article] Promoting pancreatic β cell proliferation: a powerful key for realizing regenerative therapy for diabetes.2023
- Author(s)
  Shimaya Y, Shiraki N, Kume S. Promoting pancreatic β cell proliferation: a powerful key for realizing regenerative therapy for diabetes.
- Journal Title
  
  J Diabetes Investig
  
  Volume: 14 Issue: 4 Pages: 522-524
- DOI
  10.1111/jdi.13967
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19543, KAKENHI-PROJECT-21H02978
[Journal Article] The Effect of Vitamin D3 and Valproic Acid on the Maturation of Human-Induced Pluripotent Stem Cell-Derived Enterocyte-Like Cells2023
- Author(s)
  Leo Sylvia、Kato Yusuke、Wu Yumeng、Yokota Mutsumi、Koike Masato、Yui Shiro、Tsuchiya Kiichiro、Shiraki Nobuaki、Kume Shoen
- Journal Title
  
  Stem Cells
  
  Volume: 41 Issue: 8 Pages: 775-791
- DOI
  10.1093/stmcls/sxad042
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18281, KAKENHI-PROJECT-22K07523, KAKENHI-PROJECT-23K06323, KAKENHI-PROJECT-22K19543, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-21H02898, KAKENHI-PROJECT-21H02978, KAKENHI-PROJECT-23K27578
[Journal Article] A specific plasma amino acid profile in the Insulin2Q104del Kuma mice at the diabetic state and reversal from hyperglycemia.2023
- Author(s)
  Hiyoshi N, Enomoto T, Uefune F, Kato Y, Wu Y, Araki K, Sakano D, Shiraki N, Kume S. A
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 679 Pages: 58-65
- DOI
  10.1016/j.bbrc.2023.08.064
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19543, KAKENHI-PROJECT-21H02978
[Journal Article] Protocol to generate human PSC-derived pancreatic beta-cells through methionine and zinc deprivation2023
- Author(s)
  Sim Z.E, Enomoto T, Shiraki N, Kume S
- Journal Title
  
  STAR Protocols
  
  Volume: 102183 Issue: 2 Pages: 102183-102183
- DOI
  10.1016/j.xpro.2023.102183
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19543, KAKENHI-PROJECT-21H02978
[Journal Article] Gut-Liver Microphysiological Systems Revealed Potential Crosstalk Mechanism Modulating Drug Metabolism2023
- Author(s)
  Dhimas Agung Kurniawan, Sylvia Leo, Mutsumi Inamatsu, Sohei Funaoka, Taichi Aihara, Takeshi Sakura, Hiroshi Arakawa, Yukio Kato, Tomoaki Matsugi, Katsuhiro Esashika, Nobuaki Shiraki, Shoen Kume, Hiroshi Kimura, Masaki Nishikawa, Yasuyuki Sakai,
- Journal Title
  
  PNAS NEXUS
  
  Volume: 3 Issue: 2
- DOI
  10.1093/pnasnexus/pgae070
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19543, KAKENHI-PROJECT-21H02978
[Journal Article] Methionine metabolism regulates pluripotent stem cell pluripotency and differentiation through zinc mobilization2022
- Author(s)
  Sim Z.E, Enomoto T, Shiraki N, Furuta N, Kashio S, Kambe T. Tsuyama T. Arakawa A, Ozawa H. Yokoyama M, Miura M, Kume S
- Journal Title
  
  Cell Reports
  
  Volume: 40 Issue: 3 Pages: 111120-111120
- DOI
  10.1016/j.celrep.2022.111120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19543, KAKENHI-PROJECT-21H02978, KAKENHI-PLANNED-19H05768, KAKENHI-PROJECT-23K23524, KAKENHI-PROJECT-21H04774
[Journal Article] Dopamine negatively regulates insulin secretion through D1-D2 receptor heteromer.2022
- Author(s)
  Uefune F, Aonishi T, Kitaguchi T, Takahashi H, Seino S, Sakano D, Kume S
- Journal Title
  
  Diabetes
  
  Volume: 71 Issue: 9 Pages: 1946-1961
- DOI
  10.2337/db21-0644
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19543, KAKENHI-PROJECT-19H04203, KAKENHI-PROJECT-21H02978, KAKENHI-PROJECT-20K08325
[Journal Article] Generation of human induced pluripotent stem cell-derived functional enterocyte-like cells for pharmacokinetic studies2021
- Author(s)
  Yoshida S, Honjo T, Iino K, Ishibe R, Leo S, Shimada T, Watanabe T, Ishikawa M, Maeda K, Kusuhara H, Shiraki N, Kume S.
- Journal Title
  
  Stem Cell Reports
  
  Volume: 16 Issue: 2 Pages: 295-308
- DOI
  10.1016/j.stemcr.2020.12.017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02861, KAKENHI-PROJECT-18H02154
[Journal Article] Recent progress in pancreatic islet cell therapy2021
- Author(s)
  Sim Z.E, Shiraki　N, Kume S
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 41 Issue: 1 Pages: 1-10
- DOI
  10.1186/s41232-020-00152-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02861, KAKENHI-PROJECT-18H02154, KAKENHI-PROJECT-21H02978
[Journal Article] Dietary sodium chloride attenuates increased β-cell mass to cause glucose intolerance in mice under a high-fat diet.2021
- Author(s)
  Taki K, Takagi H, Hirose T, Sun R., Yaginuma H, Mizoguchi A, Kobayashi T, Sugiyama M, Tsunekawa T, Onoue T, Hagiwara D, Ito Y, Iwama S, Suga H, Banno R, Sakano D, Kume S, Arima H,
- Journal Title
  
  Plos One
  
  Volume: 16 Issue: 3 Pages: e0248065-e0248065
- DOI
  10.1371/journal.pone.0248065
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02861, KAKENHI-PROJECT-19K20180, KAKENHI-PROJECT-21H02978, KAKENHI-PROJECT-21K11645
[Journal Article] Insulin2Q104del (Kuma) mutant mice develop diabetes with dominant inheritance2020
- Author(s)
  Sakano Daisuke、Inoue Airi、Enomoto Takayuki、Imasaka Mai、Okada Seiji、Yokota Mutsumi、Koike Masato、Araki Kimi、Kume Shoen
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 12187-12187
- DOI
  10.1038/s41598-020-68987-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07743, KAKENHI-PROJECT-20K08325, KAKENHI-PROJECT-18H02861, KAKENHI-PROJECT-16H06280
[Journal Article] Detailed analysis at a single-cell level of cells undergoing pancreatic differentiation.2020
- Author(s)
  Shiraki S, Kume S.
- Journal Title
  
  J Diabetes Investig.
  
  Volume: 11 Issue: 1 Pages: 20-21
- DOI
  10.1111/jdi.13140
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02861, KAKENHI-PROJECT-18H02154
[Journal Article] Yoshida S, Hirota M, Kawachi T, Kume S, Takahashi K. Generation of intestinal organoids derived from human pluripotent stem cells for drug testing.2020
- Author(s)
  Yoshida S, Hirota M, Kawachi T, Kume S, Takahashi K
- Journal Title
  
  Sci Reports
  
  Volume: 10 Issue: 1 Pages: 5989-5989
- DOI
  10.1038/s41598-020-63151-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02861
[Journal Article] VMAT2 Safeguards β-Cells Against Dopamine Cytotoxicity Under High-Fat Diet?Induced Stress2020
- Author(s)
  Sakano Daisuke、Uefune Fumiya、Tokuma Hiraku、Sonoda Yuki、Matsuura Kumi、Takeda Naoki、Nakagata Naomi、Kume Kazuhiko、Shiraki Nobuaki、Kume Shoen
- Journal Title
  
  Diabetes
  
  Volume: 69 Issue: 11 Pages: 26-33
- DOI
  10.2337/db20-0207
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08325, KAKENHI-PROJECT-18H02861, KAKENHI-PROJECT-18H02154
[Journal Article] Collagen vitrigel promotes hepatocytic differentiation of induced pluripotent stem cells into functional hepatocyte-like cells.2019
- Author(s)
  Nakai S, Shibata I, Shitamichi T, Yamaguchi H, Takagi N, Inoue T, Nakagawa T, Kiyokawa J, Wakabayashi S, Miyoshi T, Higashi E, Ishida S, Shiraki N, Kume S
- Journal Title
  
  Biology Open
  
  Volume: 8 Pages: 042192-042192
- DOI
  10.1242/bio.042192
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02861, KAKENHI-PROJECT-18H02154
[Journal Article] A culture substratum with net-like polyamide fibers promotes the differentiation of mouse and human pluripotent stem cells to insulin-producing cells2019
- Author(s)
  Kaitsuka Taku、Kojima Rie、Kawabe Masaaki、Noguchi Hirofumi、Shiraki Nobuaki、Kume Shoen、Tomizawa Kazuhito
- Journal Title
  
  Biomedical Materials
  
  Volume: 14 Issue: 4 Pages: 045019-045019
- DOI
  10.1088/1748-605x/ab261c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06876, KAKENHI-PROJECT-18H02861, KAKENHI-PROJECT-18H02865, KAKENHI-PROJECT-16KK0205, KAKENHI-PROJECT-18H02154
[Journal Article] iPS cell elimination in a cell sheet by methionine-free and 42 °C condition for tumor prevention.2018
- Author(s)
  Matsuura K, Ito K, Shiraki N, Kume S, Hagiwara N, Shimizu T.
- Journal Title
  
  Tissue Eng Part C Methods.
  
  Volume: 24 Issue: 10 Pages: 605-615
- DOI
  10.1089/ten.tec.2018.0228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02861, KAKENHI-PROJECT-16K01362, KAKENHI-PROJECT-18H02154
[Journal Article] Different murine-derived feeder cells alter the definitive endoderm differentiation of human induced pluripotent stem cells.2018
- Author(s)
  Shoji M, Minato H, Ogaki S, Seki M , Suzuki Y, Kume S, Kuzuhara T.
- Journal Title
  
  PLoS ONE
  
  Volume: 13 Issue: 7 Pages: e0201239-e0201239
- DOI
  10.1371/journal.pone.0201239
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06645, KAKENHI-PROJECT-18H02861
[Journal Article] Future perspectives for the treatment of diabetes: importance of a regulatory framework.2018
- Author(s)
  Tsukamoto K, Cnop M, Mori D, Kume S, Anazawa T, Doi M, Chikazawa K, Matsumaru N
- Journal Title
  
  Ther Innov Regul Sci.
  
  Volume: Sep 3 Issue: 4 Pages: 535-541
- DOI
  10.1177/2168479018795854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K01362, KAKENHI-PROJECT-18H02861
[Journal Article] Inhibition of Cdk5 Promotes β-cell differentiation from ductal progenitors2018
- Author(s)
  Liu KC, Leuckx G, Sakano D, Seymour PA, Mattssona CL, Rautioa L, Verdonck Yannick, Serup P, Kume S, Heimberg H, Andersson O
- Journal Title
  
  Diabetes
  
  Volume: 67 Issue: 1 Pages: 58-70
- DOI
  10.2337/db16-1587
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02861, KAKENHI-PROJECT-16K01362
[Journal Article] Heterogeneity of beta-cells.2017
- Author(s)
  Shoen Kume
- Journal Title
  
  J Diabetes Investig
  
  Volume: 印刷中 Issue: 5 Pages: 656-657
- DOI
  10.1111/jdi.12608
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26253059
[Journal Article] Mild electrical stimulation with heat shock guides differentiation of embryonic stem cells into Pdx1-expressing cells within the definitive endoderm.2017
- Author(s)
  Koga T, Shiraki N, Yano S, Suico MA, Morino-Koga S, Sato T, Shuto T, Kume S, Kai H
- Journal Title
  
  BMC Biotechnology
  
  Volume: 17 Issue: 1 Pages: 14-14
- DOI
  10.1186/s12896-017-0331-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461638, KAKENHI-PROJECT-15K12514, KAKENHI-PROJECT-15K19032, KAKENHI-PROJECT-16K01362, KAKENHI-PROJECT-16K18875
[Journal Article] Erythropoietin facilitates definitive endodermal differentiation of mouse embryonic stem cells via activation of ERK signaling2017
- Author(s)
  Kaitsuka T, Kobayashi K, Otsuka W, Kubo T, Hakim F, Wei FY, Shiraki N, Kume S and Tomizawa K
- Journal Title
  
  Am. J. of Physiology - Cell Physiology
  
  Volume: 312 Issue: 5 Pages: C573-C582
- DOI
  10.1152/ajpcell.00071.2016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461638, KAKENHI-PROJECT-15K18971, KAKENHI-PROJECT-16K01362, KAKENHI-PROJECT-15F15110
[Journal Article] Changes in expression of C2cd4c in pancreatic endocrine cells during pancreatic development2016
- Author(s)
  Omori H, Ogaki S, Sakano D, Sato M, Umeda K, , Nakagata N, Kume S
- Journal Title
  
  FEBS Lett
  
  Volume: 590 Issue: 16 Pages: 2584-93
- DOI
  10.1002/1873-3468.12271
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26253059
[Journal Article] Late stage definitive endodermal differentiation can be defined by Daf1 expression2016
- Author(s)
  Ogaki S, Omori H, Morooka M, Shiraki N, Ishida S, Kume S
- Journal Title
  
  BMC Dev Biol
  
  Volume: 16 Issue: 1 Pages: 19-19
- DOI
  10.1186/s12861-016-0120-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461638, KAKENHI-PROJECT-26253059
[Journal Article] Temporal effects of Notch signaling and potential cooperation with multiple downstream effectors on adenohypophysis cell specification in zebrafish2016
- Author(s)
  Y. Nakahara, A. Muto, R. Hirabayashi, T. Sakuma, T. Yamamoto, S. Kume, and Y. Kikuchi
- Journal Title
  
  Genes to Cells
  
  Volume: 21 Issue: 5 Pages: 492-504
- DOI
  10.1111/gtc.12358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26430185, KAKENHI-PROJECT-26253059
[Journal Article] Dopamine D2 receptor-mediated regulation of pancreatic b cell mass.2016
- Author(s)
  １.Sakano D, Choi S, Kataoka M, Shiraki N, Uesugi M, Kume K, Kume S
- Journal Title
  
  Stem Cell Reports
  
  Volume: ７ Issue: 1 Pages: 95-109
- DOI
  10.1016/j.stemcr.2016.05.015
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461036, KAKENHI-PROJECT-26461638, KAKENHI-PROJECT-16K01362, KAKENHI-PROJECT-26253059
[Journal Article] Quantification of intracellular Zn, Fe, Cu within both iPS cells and differentiated cells using HPLC coupled to ICP-MS.2016
- Author(s)
  Arakawa A, Shiraki N, Tsuyama T, Kume S, Iwahata D, Yamada N
- Journal Title
  
  J. Anal Bioanal Tech
  
  Volume: 7 Pages: 1000295-1000295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26253059
[Journal Article] A cost effective system for differentiation of intestinal epithelium from human induced pluripotent stem cells.2015
- Author(s)
  Ogaki S, Morooka M, Otera K and Kume S.
- Journal Title
  
  Sci Rep
  
  Volume: 5 Issue: 1 Pages: 17297-17297
- DOI
  10.1038/srep17297
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26670384, KAKENHI-PROJECT-26253059
[Journal Article] 「ES/iPS細胞からの内胚葉組織形成」2015
- Author(s)
  大垣総一郎　粂昭苑
- Journal Title
  
  生化学
  
  Volume: 87 Pages: 573-581
- NAID
  40020650104
- Data Source
  KAKENHI-PROJECT-26670384
[Journal Article] Neural cells play an inhibitory role in pancreatic differentiation of pluripotent stem cells.2015
- Author(s)
  Nakashima R, Morooka M, Shiraki N, Sakano D, Ogaki S, Kume K, Kume S
- Journal Title
  
  Genes to cells
  
  Volume: 20 Issue: 12 Pages: 1028-45
- DOI
  10.1111/gtc.12308
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461638, KAKENHI-PROJECT-26253059
[Journal Article] Definitive endoderm differentiation of human embryonic stem cells combined with selective elimination of undifferentiated cells by methionine deprivation.2015
- Author(s)
  Tsuyama T, Shiraki N, Kume S
- Journal Title
  
  Methods Mol Biol.
  
  Volume: Epub
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670384
[Journal Article] Pancreatic differentiation from murine ES cells2015
- Author(s)
  Sakano D, Shiraki N, Kume S.
- Journal Title
  
  Methods Mol Biol.
  
  Volume: Epub
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670384
[Journal Article] The NMDA receptor promotes sleep in the fruit fly, Drosophila melanogaster.2015
- Author(s)
  Tomita, J., Ueno, T., Mitsuyoshi, M., Kume, S. and Kume, K.
- Journal Title
  
  PLoS ONE
  
  Volume: 10 Issue: 5 Pages: e0128101-e0128101
- DOI
  10.1371/journal.pone.0128101
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26507008, KAKENHI-PROJECT-26560458, KAKENHI-PROJECT-25290007, KAKENHI-PROJECT-26702037, KAKENHI-PROJECT-26253059
[Journal Article] Beneficial effect of insulin treatment on islet transplantation outcomes in akita mice.2014
- Author(s)
  Kikawa K, Sakano D, Shiraki N, Tsuyama T, Kume K, Endo F, Kume S.
- Journal Title
  
  Plos one
  
  Volume: 9(4) Issue: 4 Pages: e95451-e95451
- DOI
  10.1371/journal.pone.0095451
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461036, KAKENHI-PROJECT-26461638, KAKENHI-PROJECT-26253059
[Journal Article] Hepatic differentiation from human iPS cells using M15 cells2014
- Author(s)
  Umeda K, Shiraki N, Kume S
- Journal Title
  
  Methods Mol Biol.
  
  Volume: Epub
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670384
[Journal Article] Profiling of embryonic stem cell differentiation.2014
- Author(s)
  Shiraki N., Ogaki S and Kume S
- Journal Title
  
  The Review of Diabetic Studies
  
  Volume: 11(1) Issue: 1 Pages: 102-114
- DOI
  10.1900/rds.2014.11.102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-14J01021, KAKENHI-PROJECT-26461638, KAKENHI-PROJECT-26670384, KAKENHI-PROJECT-26253059
[Journal Article] High Oxygen Condition Facilitates the Differentiation of Mouse and Human Pluripotent Stem Cells into Pancreatic Progenitors and Insulin-producing Cells.2014
- Author(s)
  Farzana Hakim, Taku Kaitsuka, Jamiruddin Mohd. Raeed, Fan-Yan Wei, Nobuaki Shiraki, Tadayuki Akagi, Takashi Yokota, Shoen Kume, and Kazuhito Tomizawa
- Journal Title
  
  The journal of biological chemistry
  
  Volume: 289 Issue: 14 Pages: 9623-9638
- DOI
  10.1074/jbc.m113.524363
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24790217, KAKENHI-PROJECT-24790274, KAKENHI-PROJECT-25860753, KAKENHI-PROJECT-26461638, KAKENHI-PROJECT-26253059
[Journal Article] Methionine metabolism regulates maintenance and differentiation of human pluripotent stem cells.2014
- Author(s)
  Shiraki, N., Shiraki, Y., Tsuyama, T., Obata, F., Miura, M., Nagae, G., Aburatani, H., Kume, K., Endo, F., and Kume, S.
- Journal Title
  
  Cell Metab.
  
  Volume: 19 Issue: 5 Pages: 780-794
- DOI
  10.1016/j.cmet.2014.03.017
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23229002, KAKENHI-PROJECT-25670080, KAKENHI-PROJECT-25860521, KAKENHI-PROJECT-26461638, KAKENHI-PROJECT-26670384, KAKENHI-PROJECT-26253059
[Journal Article] Hepatic differentiation from murine and human iPS cells using nanofiber scaffolds2014
- Author(s)
  Yamazoe T., Shiraki N., Kume S.
- Journal Title
  
  Methods Mol Biol.
  
  Volume: epub Pages: 475-83
- DOI
  10.1007/7651_2014_138
- ISBN
  9781493930548, 9781493930555
- Data Source
  KAKENHI-PROJECT-26893201, KAKENHI-PROJECT-26461638
[Journal Article] Generation of insulin-producing beta-like cells from human iPS cells in a defined and completely Xeno-free culture system.2014
- Author(s)
  Shahjalal HM, Shiraki N, Sakano D, Kikawa H, Ogaki S, Baba H, Kume K., Kume S.
- Journal Title
  
  Journal of Molecular Cell Biology
  
  Volume: 6 Issue: 5 Pages: 394-408
- DOI
  10.1093/jmcb/mju029
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-14J01021, KAKENHI-PROJECT-26461036, KAKENHI-PROJECT-26461638, KAKENHI-PROJECT-26670384, KAKENHI-PROJECT-26253059
[Journal Article] Sexually dimorphic expression of Mafb regulates masculinization of the embryonic urethral formation2014
- Author(s)
  Suzuki K, Numata T, Suzuki H, Raga DD, Ipulana L, Yokoyama C, Matsushita S, Hamada M, Nakagata N, Nishinakamura R, Kume S, Takahashi S, and Yamada G.
- Journal Title
  
  PNAS
  
  Volume: 18;111(46) Issue: 46 Pages: 16407-12
- DOI
  10.1073/pnas.1413273111
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22132006, KAKENHI-PROJECT-25860205, KAKENHI-PROJECT-26670384
[Journal Article] Hepatic differentiation from murine and human iPS cells using nanofiber scaffolds2014
- Author(s)
  Yamazoe T, Shiraki N, Kume S
- Journal Title
  
  Methods Mol Biol.
  
  Volume: Epub
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670384
[Journal Article] VMAT2 identified as a regulator of late-stage beta cell differentiation.2013
- Author(s)
  Sakano, D., Shiraki, N., Kikawa, K., Yamazoe, T., Kataoka, M., Umeda, K., Araki, K., Mao, D., Matsumoto, S., Nakagata, N., Andersson, O., Stainier, D., Endo, F., Kume, K., Uesugi, M. and Kume, S.
- Journal Title
  
  Nat. Chem. Biol.
  
  Volume: 10 Issue: 2 Pages: 141-148
- DOI
  10.1038/nchembio.1410
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310135, KAKENHI-PUBLICLY-24115712, KAKENHI-PROJECT-24790949, KAKENHI-PROJECT-26461036, KAKENHI-PROJECT-26253059
[Journal Article] Influence of 60 ns Pulsed electric fields on embryonic stem cells.2011
- Author(s)
  Akiyama, M., Shiraishi E., Sakugawa T, Hosseini, SHR., Akiyama H., Shiraki N., Kume S.
- Journal Title
  
  IEEE transactions on DEI
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390280
[Journal Article] Xenopus embryos and ES cells as tools for studies of developmental biology.2011
- Author(s)
  Kume, S.
- Journal Title
  
  Neurochem Res.
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390280
[Journal Article] In vitro models of pancreatic differentiation using ES or iPS cells.2011
- Author(s)
  Higuchi Y., Shiraki N., Kume, S
- Journal Title
  
  Congenital Anomalies
  
  Volume: 51 Pages: 21-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390280
[Journal Article] An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells.2011
- Author(s)
  Ogaki S, Harada S, Shiraki N, Kume K, Kume S.
- Journal Title
  
  BMC Developmental Biology
  
  Volume: 11 Pages: 13-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390280
[Journal Article] Endoderm and mesoderm reciprocal signaling mediated by CXCL12 and CXCR4 regulates the migration of angioblasts and establishes the pancreatic fate.2011
- Author(s)
  Katsumoto, K., Kume, S.
- Journal Title
  
  Development
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390280
[Journal Article] Epiplakin1 is expressed in the cholangiocyte lineage cells in normal liver and adult progenitor cells in injured liver.2011
- Author(s)
  Matsuo A., Yoshida T., Yasukawa T., Miki R., Kazuhiko K., Kume S.
- Journal Title
  
  MOD-Gene Expression Patterns
  
  Volume: 11 Pages: 255-262
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390280
[Journal Article] Synthesized basement membranes direct the differentiation of mouse embryonic stem cells into pancreatic lineages.2010
- Author(s)
  Higuchi Y, Shiraki N, Yamane K, Qin Z, Mochitate K, Hara M, Kume K, Kume S.
- Journal Title
  
  J.Cell Science
  
  Volume: 123 Pages: 2733-2742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390280
[Journal Article] Expression of Epiplakin 1 in the developing and adult mouse retina2010
- Author(s)
  Yoshida, T., Guo, X., Namekata, K., Mitamura, Y., Kume, S., Harada T.
- Journal Title
  
  Jpn J Ophthalmol 54
  
  Pages: 85-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390280
[Journal Article] Guiding ES cell differentiation into the definitive endoderm lineages.2010
- Author(s)
  Shiraki S., Higuchi Y., Kume S
- Journal Title
  
  Inflamation and Regeneration
  
  Volume: 30 Pages: 109-114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390280
[Journal Article] Embryonic and adult stem cell syst ems in mammals: Ontology and regulation2010
- Author(s)
  Keiichi Katsumoto, Nobuaki Shiraki, Rika Miki, Shoen Kume
- Journal Title
  
  Development, Growth&Differentiation 52
  
  Pages: 115-129
- NAID
  10027563368
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790652
[Journal Article] Embryonic and adult stem cell systems in mammals : Ontology and regulation" in 'Comparative aspects of Stem cells'2010
- Author(s)
  Katsumoto, K., Shiraki, N., Miki, R., Kume, S.
- Journal Title
  
  Develop.Growth Diff 52
  
  Pages: 115-129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390280
[Journal Article] Identification of DAF1/CD55, a novel definitive endoderm marker.2010
- Author(s)
  Shiraki N, Harada S, Ogaki S, Kume K., Kume S
- Journal Title
  
  Cell Struct.Funct.
  
  Volume: 35 Pages: 73-80
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390280
[Journal Article] Conserved origin of the ventral pancreas in chicken.2009
- Author(s)
  Kumi Matsuura*, Keiichi Katsumoto*, Kimiko Fukuda, Kazuhiko Kume, Shoen Kume(* equal contribution)
- Journal Title
  
  Mechanisms of Development 126(10)
  
  Pages: 817-827
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790652
[Journal Article] Analysis of gene expressions of ES-derived Pdx1-expressing cells : Implications of genes involved in pancreas differentiation2009
- Author(s)
  Yoshida, T., Murata, K., Shiraki, N., Kume, K., Kume, S.
- Journal Title
  
  Develop.Growth Differ. 51
  
  Pages: 463-472
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390280
[Journal Article] Origin of pancreatic precursors in the chick embryo and the mechanism of endoderm regionalization.2009
- Author(s)
  Keiichi Katsumoto, Kimiko Fukuda, Wataru Kimura, Kenji Shimamura, Sadao Yasugi, Shoen Kume
- Journal Title
  
  Mechanisms of Development 126(7)
  
  Pages: 539-551
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790652
[Journal Article] Differentiation and characterization of embryonic stem cells into three germ layers2009
- Author(s)
  Shiraki, N., Higuchi, Y., Harada, S., Umeda, K., Isagawa, T., Aburatani, H., Kume, K., Kume, S.
- Journal Title
  
  Biochem.Biophys.Res.Comm. 381
  
  Pages: 694-699
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390280
[Journal Article] Origin of the ventral pancreatic precursors2009
- Author(s)
  Matsuura, K., Katsumoto, K., Fukuda, K., Kume, K., Kume, S.
- Journal Title
  
  Mech.Dev.
  
  Pages: 817-827
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390280
[Journal Article] Origin of pancreatic precursors and the mechanism of endoderm regionalization in chick embryos2009
- Author(s)
  Katsumoto, K., Fukuda, K., Kimura, W., Shimamura, K., Yasugi, S., Kume, S.
- Journal Title
  
  Mech.Dev. 126
  
  Pages: 539-551
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390280
[Journal Article] ヒトES細胞を用いた肝胆膵の発生分化と再生医学研究2007
- Author(s)
  粂昭苑
- Journal Title
  
  ヒトES細胞研究のネクストステージ(医学のあゆみ)(中辻憲夫他編集)(医歯薬出版刊行) 220
  
  Pages: 153-157
- Data Source
  KAKENHI-PROJECT-18659210
[Journal Article] ヒトE S細胞を用いた肝胆膵の発生分化と再生医学研究2007
- Author(s)
  粂昭苑
- Journal Title
  
  ヒトES細胞研究のネクストステージ(医学のあゆみ)(中辻憲夫他編集)(医歯薬出版刊行) 220
  
  Pages: 153-157
- Data Source
  KAKENHI-PROJECT-17045026
[Journal Article] 消化器官における幹細胞研究の動向2007
- Author(s)
  粂昭苑, 谷口英樹
- Journal Title
  
  内胚葉分化の分子メカニズム(特集号蛋白核酸酵素)(菊池裕編集)(共立出版刊行) 52
  
  Pages: 139-144
- Data Source
  KAKENHI-PROJECT-18659210
[Journal Article] 消化器官における幹細胞研究の動向2007
- Author(s)
  粂昭苑, 谷口英樹
- Journal Title
  
  内胚葉分化の分子メカニズム(特集号蛋白核酸酵素)(菊池裕編集)(共立出版刊行) 52
  
  Pages: 139-144
- Data Source
  KAKENHI-PROJECT-17045026
[Journal Article] Pancreatic development and stem cell-based regenerative medicine.2006
- Author(s)
  Kume S, Shiraki N
- Journal Title
  
  Rinsho Byori 54
  
  Pages: 386-392
- NAID
  10018015040
- Data Source
  KAKENHI-PROJECT-17045026
[Journal Article] ES細胞から膵β細胞への誘導2006
- Author(s)
  白木伸明, 粂昭苑
- Journal Title
  
  ここまで進んだ幹細胞研究と再生医療2006(実験医学)(田賀哲也他編集) 24
  
  Pages: 182-187
- Data Source
  KAKENHI-PROJECT-18659210
[Journal Article] 膵臓の分化誘導シグナルと糖尿病モデル動物2006
- Author(s)
  勝本恵一, 粂昭苑
- Journal Title
  
  シグナル伝達病を知る-その分子機序解明から新たな治療戦略まで-(遺伝子医学MOOK)(菅村和夫他編集)(メデイカルドウ刊行) 6
  
  Pages: 260-26
- Data Source
  KAKENHI-PROJECT-18659210
[Journal Article] ES細胞から膵β細胞への誘導2006
- Author(s)
  白木伸明, 粂昭苑
- Journal Title
  
  ここまで進んだ幹細胞研究と再生医療2006(田賀哲也他編集)(実験医学) 24
  
  Pages: 182-187
- Data Source
  KAKENHI-PROJECT-17045026
[Journal Article] 生物時計出力系としての睡眠覚醒制御2006
- Author(s)
  粂和彦
- Journal Title
  
  実験医学 24
  
  Pages: 484-490
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300108
[Journal Article] 膵臓の分化誘導シグナルと糖尿病モデル動物2006
- Author(s)
  勝本恵一, 粂昭苑
- Journal Title
  
  シグナル伝達病を知る-その分子機序解明から新たな治療戦略まで-(遺伝子医学MOOK)(菅村和夫他編集)(メデイカルドウ刊行) 6
  
  Pages: 260-26
- Data Source
  KAKENHI-PROJECT-17045026
[Journal Article] Pancreatic development and stem cell-based regenerative medicine.2006
- Author(s)
  Kume S, Shiraki N
- Journal Title
  
  Rinsho Byori 54
  
  Pages: 386-392
- NAID
  10018015040
- Data Source
  KAKENHI-PROJECT-18659210
[Journal Article] TGF-βsignaling potentiates differentiation of embryonic stem cells to Pdx-1 expressing endodermal cells.2005
- Author(s)
  Shiraki N., Lai C-J., Hishikari Y., Kume S.
- Journal Title
  
  Genes Cells 10
  
  Pages: 503-516
- Data Source
  KAKENHI-PROJECT-16027239
[Journal Article] Dopamine is a regulator of arousal in the fruit fly2005
- Author(s)
  Kume, K. et al.
- Journal Title
  
  J. Neurosci. 25
  
  Pages: 7377-7384
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300108
[Journal Article] Dopamine is a regulator of arousal in the fruit fly.2005
- Author(s)
  Kume, K. et al.
- Journal Title
  
  J.Neurosci. 25
  
  Pages: 7377-7384
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300108
[Journal Article] A Drosophila dopamine transporter mutant, fmn (fumin) is defective in arousal regulations2005
- Author(s)
  Kume, K. et al.
- Journal Title
  
  Sleep Biol. Rhythm 印刷中
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300108
[Journal Article] Autophagic cell death of pancreatic acinar cells in serineprotease inhibitor Kazal type 3 deficient mice.2005
- Author(s)
  Ohmuraya M, Hirota M, Araki M, Mizushima N, Matsui M, Mizumoto T, Haruna K, Kume S, Takeya M, Ogawa M, Araki K, Yamamura K-I.
- Journal Title
  
  Gastroenterology 129
  
  Pages: 696-705
- Data Source
  KAKENHI-PROJECT-17045026
[Journal Article] TGF-β signaling potentiates differentiation of embryonic stem cells to Pdx-1 expressing endodermal cells.2005
- Author(s)
  Shiraki N., Lai C-J., Hishikari Y., Kume S.
- Journal Title
  
  Genes to Cells (in press)
- Data Source
  KAKENHI-PROJECT-15039226
[Journal Article] Enhanced expression of PDX-1 and Ngn3 by exendin-4 during ・ cell regeneration in STZ-treated mice.2005
- Author(s)
  Kodama, K., Toyonaga, T., Kondo, T., Matsumoto, K., Tsuruzoe, K., Kawashima, J., Goto, H., Kume, K., Kume, S., Sakakida, M., Araki, E.
- Journal Title
  
  Biochem.Biophys.Res.Comm. 327
  
  Pages: 1170-1178
- Data Source
  KAKENHI-PROJECT-16011248
[Journal Article] Dopamine is a regulator of arousal in the fruit fly2005
- Author(s)
  Kume, K., Kume, S., Park, S.K., Hirsh, J., Jackson, FR.
- Journal Title
  
  J.Neuroscience 25
  
  Pages: 7377-7384
- Data Source
  KAKENHI-PROJECT-16027239
[Journal Article] Enhanced expression of PDX-1 and Ngn3 by exendin-4 during ・ cell regeneration in STZ-treated mice.2005
- Author(s)
  Kodama, K., Toyonaga, T., Kondo, T., Matsumoto, K., Tsuruzoe, K., Kawashima, J., Goto, H., Kume, K., Kume, S., Sakakida, M., Araki, E.
- Journal Title
  
  Biochem.Biophys.Res.Comm. 327
  
  Pages: 1170-1178
- Data Source
  KAKENHI-PROJECT-16027239
[Journal Article] TGF-β signaling potentiates differentiation of embryonic stem cells to Pdx-1 expressing endodermal cells.2005
- Author(s)
  Shiraki N., Lai C-J., Hishikari Y., Kume S.
- Journal Title
  
  Genes to Cells (in press)
- Data Source
  KAKENHI-PROJECT-16027239
[Journal Article] TGF-β signaling potentiates differentiation of embryonic stem cells to Pdx-1 expressing endodermal cells.2005
- Author(s)
  Shiraki N., Lai C-J., Hishikari Y., Kume S.
- Journal Title
  
  Genes Cells 10
  
  Pages: 503-516
- Data Source
  KAKENHI-PROJECT-17045026
[Journal Article] A Drosophila dopamine transporter mutant, fmn (fumin) is defective in arousal regulations2005
- Author(s)
  Kume, K.
- Journal Title
  
  Sleep Biol.Rhythm (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300108
[Journal Article] Enhanced expression of PDX-1 and Ngn3 by exendin-4 during β cell regeneration in STZ-treated mice2005
- Author(s)
  Kodama, S., Toyonaga, T., Kondo, T., Matsumoto, K., Tsuruzoe, K., Kawashima, J., Goto, H., Kume, K., Kume.S., Sakakida, M., Araki, E.
- Journal Title
  
  Biochem. Biophys. Res. Comm. 327
  
  Pages: 1170-1178
- Data Source
  KAKENHI-PROJECT-16027239
[Journal Article] Autophagic cell death of pancreatic acinar cells in serineprotease inhibitor Kazal type 3 deficient mice.2005
- Author(s)
  Ohmuraya M, Hirota M, Araki M, Mizushima N, Mitsui M, Mizumoto T, Haruna K, Kume S. Takeya M, Ogawa M, Araki K, Yamamura K-I.
- Journal Title
  
  Gastroenterology 129
  
  Pages: 696-705
- Data Source
  KAKENHI-PROJECT-16027239
[Journal Article] TGF-β signaling potentiates differentiation of embryonic stem cells to Pdx-1 expressing endodermal cells.2005
- Author(s)
  Shiraki N., Lai C-J., Hishikari Y., Kume S.
- Journal Title
  
  Genes to Cells (in press)
- Data Source
  KAKENHI-PROJECT-16011248
[Journal Article] Enhanced expression of PDX-1 and Ngn3 by exendin-4 during ・ cell regeneration in STZ-treated mice.2005
- Author(s)
  Kodama, K., Toyonaga, T., Kondo, T., Matsumoto, K., Tsuruzoe, K., Kawashima, J., Goto, H., Kume, K., Kume, S., Sakakida, M., Araki, E.
- Journal Title
  
  Biochem.Biophys.Res.Comm. 327
  
  Pages: 1170-1178
- Data Source
  KAKENHI-PROJECT-15039226
[Journal Article] Enhanced expression of PDX-1 and Ngn3 by exendin-4 during β cell regeneration in STZ-treated mice2005
- Author(s)
  Kodama, S., Toyonaga, T., Kondo, T., Matsumoto, K., Tsuruzoe, K., Kawashima, J., Goto, H., Kume, K., Kume.S., Sakakida, M., Araki, E.
- Journal Title
  
  Biochem. Biophys. Res. Comm. 327
  
  Pages: 1170-1178
- Data Source
  KAKENHI-PROJECT-17045026
[Journal Article] Dopamine is a regulator of arousal in the fruit fly2005
- Author(s)
  Kume, K., Kume, S., Park, S.K., Hirsh, J., Jackson, FR.
- Journal Title
  
  J.Neuroscience 25
  
  Pages: 7377-7384
- Data Source
  KAKENHI-PROJECT-17045026
[Patent] 糖尿病モデル動物2018
- Inventor(s)
  粂昭苑、坂野大介、榎本孝幸、荒木喜美、岡田誠治
- Industrial Property Rights Holder
  東京工業大学、熊本大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-076855
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-18H02861
[Patent] インスリン産生細胞の分化誘導方法2015
- Inventor(s)
  粂　昭苑、白木伸明
- Industrial Property Rights Holder
  粂　昭苑、白木伸明
- Industrial Property Rights Type
  特許
- Filing Date
  2015-05-19
- Overseas
- Data Source
  KAKENHI-PROJECT-26253059
[Patent] アミノ酸組成変更培地を用いた幹細胞の分化促進方法、及び該方法を用いて処理された幹細胞、並びに培地2015
- Inventor(s)
  粂　昭苑、遠藤文夫、白木伸明、白木恭子、粂　和彦、馬渡一徳
- Industrial Property Rights Holder
  粂　昭苑、遠藤文夫、白木伸明、白木恭子、粂　和彦、馬渡一徳
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-184294
- Filing Date
  2015-09-10
- Data Source
  KAKENHI-PROJECT-26253059
[Patent] インスリン産生細胞の分化誘導方法2014
- Inventor(s)
  粂　昭苑、白木伸明
- Industrial Property Rights Holder
  粂　昭苑、白木伸明
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-104019
- Filing Date
  2014-05-20
- Data Source
  KAKENHI-PROJECT-26253059
[Patent] 多能性幹細胞の分化誘導効率を改善するための方法及び培地2010
- Inventor(s)
  粂昭苑、遠藤文夫、白木伸明、白木恭子、粂和彦
- Industrial Property Rights Holder
  熊本大学
- Industrial Property Number
  2010-242774
- Filing Date
  2010-10-28
- Data Source
  KAKENHI-PROJECT-21390280
[Patent] 腸細胞の製造方法2010
- Inventor(s)
  粂昭苑、白木伸明、粂和彦, 大垣総一郎
- Industrial Property Rights Holder
  熊本大学
- Industrial Property Number
  2010-246161
- Filing Date
  2010-11-02
- Data Source
  KAKENHI-PROJECT-21390280
[Patent] 細胞の分化誘導方法2009
- Inventor(s)
  粂昭苑, 白木伸明, 粂和彦
- Industrial Property Rights Holder
  熊本大学
- Industrial Property Number
  2009-254336
- Filing Date
  2009-11-05
- Data Source
  KAKENHI-PROJECT-21390280
[Patent] 細胞の分化誘導2009
- Inventor(s)
  粂昭苑, 白木伸明, 樋口裕一郎, 梅田香穂子, 粂和彦, 山根恵太郎, 持立克身
- Industrial Property Rights Holder
  熊本大学
- Industrial Property Number
  2009-136520
- Filing Date
  2009-06-10
- Data Source
  KAKENHI-PROJECT-21390280
[Patent] 内胚葉細胞、腸管細胞膵細胞の検出方法2009
- Inventor(s)
  粂昭苑, 原田聖子, 白木伸明, 粂和彦
- Industrial Property Rights Holder
  熊本大学
- Industrial Property Number
  2009-225758
- Filing Date
  2009-06-30
- Data Source
  KAKENHI-PROJECT-21390280
[Patent] 「ES細胞の分化誘導方法」2007
- Inventor(s)
  粂昭苑, 吉田哲, 白木伸明, 粂和彦
- Industrial Property Rights Holder
  国立大学法人, 熊本大学
- Filing Date
  2007-05-24
- Overseas
- Data Source
  KAKENHI-PROJECT-18659210
[Patent] 「ES細胞から肝細胞の分化誘導方法]2007
- Inventor(s)
  粂昭苑, 白木伸明, 梅田香穂子, 粂和彦
- Industrial Property Rights Holder
  国立大学法人, 熊本大学
- Industrial Property Number
  2007-143225
- Filing Date
  2007-05-30
- Data Source
  KAKENHI-PROJECT-18659210
[Presentation] Transient methionine deprivation triggers histone modification and potentiates differentiation of induced pluripotent stem cells.2023
- Author(s)
  Hiroki Ozawa, Azusa Kambe, Kodai Hibi, Satoshi Murakami, Akira Oikawa, Tetsuya Handa, Katsunori Fujiki, Ryuichiro Nakato, Katsuhiko Shirahige, Hiroshi Kimura, Nobuaki Shiraki and Shoen Kume
- Organizer
  ISSCR
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02978
[Presentation] 多能性幹細胞の未分化および分化状態における細胞内亜鉛動態解析2023
- Author(s)
  門倉瑶乃、荒川哲大、Erinn Zixuan Sim、白木伸明、粂昭苑
- Organizer
  日本再生医療学会
- Data Source
  KAKENHI-PROJECT-22K19543
[Presentation] 共培養系を用いたiPS-小腸細胞と肝細胞との相互作用の解析2023
- Author(s)
  木村莉瑠, 西藤巧, 渡邊輝彦,長田優菜,白木伸明, 粂昭苑
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-22K19543
[Presentation] 多能性幹細胞由来膵島の分化誘導研究2023
- Author(s)
  粂昭苑
- Organizer
  日本糖尿病学会九州地方会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02978
[Presentation] HSVTK-GCV自殺スイッチを利用したiPS細胞由来β細胞における造腫瘍抑制2023
- Author(s)
  岸本恵理子, 徳間啓, 白木伸明, 坂野大介, 粂昭苑
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-22K19543
[Presentation] 膵臓β細胞における不均一なドーパミン合成能の生理学的役割の解明2023
- Author(s)
  富永成海, 上船史弥, 井上愛里, 板谷勇輝, 徳間啓, 白木伸明, 坂野大介, 粂昭苑
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-22K19543
[Presentation] 多能性幹細胞からの膵分化誘導におけるメチオニンと亜鉛シグナルの役割2023
- Author(s)
  粂昭苑
- Organizer
  日本生化学会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19543
[Presentation] 多能性幹細胞の未分化および分化状態における細胞内亜鉛動態解析2023
- Author(s)
  門倉瑶乃、荒川哲大、Erinn Zixuan Sim、白木伸明、粂昭苑
- Organizer
  日本再生医療学会
- Data Source
  KAKENHI-PROJECT-21H02978
[Presentation] Methionine metabolism regulates pluripotent stem cell through zinc mobilization.2023
- Author(s)
  Nobuaki Shiraki, Erinn Zixuan Sim, Takayuki Enomoto, Nao Furuta, Soshiro Kashio, Taiho Kambe, Tomonori Tsuyama, Akihiro Arakawa, Hiroki Ozawa, Mizuho Yokoyama, Masayuki Miura, Shoen Kume
- Organizer
  ISSCR
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02978
[Presentation] 5-アミノレブリン酸を用いた光線力学療法のヒトiPS膵臓分化誘導への応用2023
- Author(s)
  鈴木秀宜・小倉俊一郎・白木伸明・粂昭苑
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-22K19543
[Presentation] Generation of induced pluripotent Stem Cell-Derived Beta cells in Blood Amino Acids-Like Medium2023
- Author(s)
  Marwa san, Y Kato, Shiraki N, Kume S.
- Organizer
  22nd IUNS-InternationalCongress of Nutrition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02978
[Presentation] 膵臓β細胞における不均一なドーパミン合成能の生理学的役割の解明2023
- Author(s)
  富永成海, 上船史弥, 井上愛里, 板谷勇輝, 徳間啓, 白木伸明, 坂野大介, 粂昭苑
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21H02978
[Presentation] 5-アミノレブリン酸を用いた光線力学療法のヒトiPS膵臓分化誘導への応用2023
- Author(s)
  鈴木秀宜・小倉俊一郎・白木伸明・粂昭苑
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21H02978
[Presentation] 多能性幹細胞からの膵分化誘導におけるメチオニンと亜鉛シグナルの役割2023
- Author(s)
  粂昭苑
- Organizer
  日本生化学会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02978
[Presentation] Methionine metabolism regulates pluripotent stem cell through zinc mobilization.2023
- Author(s)
  Nobuaki Shiraki, Erinn Zixuan Sim, Takayuki Enomoto, Nao Furuta, Soshiro Kashio, Taiho Kambe, Tomonori Tsuyama, Akihiro Arakawa, Hiroki Ozawa, Mizuho Yokoyama, Masayuki Miura, Shoen Kume
- Organizer
  ISSCR
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19543
[Presentation] 多能性幹細胞由来膵島の分化誘導研究2023
- Author(s)
  粂昭苑
- Organizer
  日本糖尿病学会九州地方会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19543
[Presentation] 共培養系を用いたiPS-小腸細胞と肝細胞との相互作用の解析2023
- Author(s)
  木村莉瑠, 西藤巧, 渡邊輝彦,長田優菜,白木伸明, 粂昭苑
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21H02978
[Presentation] HSVTK-GCV自殺スイッチを利用したiPS細胞由来β細胞における造腫瘍抑制2023
- Author(s)
  岸本恵理子, 徳間啓, 白木伸明, 坂野大介, 粂昭苑
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21H02978
[Presentation] Transient methionine deprivation triggers histone modification and potentiates differentiation of induced pluripotent stem cells.2023
- Author(s)
  Hiroki Ozawa, Azusa Kambe, Kodai Hibi, Satoshi Murakami, Akira Oikawa, Tetsuya Handa, Katsunori Fujiki, Ryuichiro Nakato, Katsuhiko Shirahige, Hiroshi Kimura, Nobuaki Shiraki and Shoen Kume
- Organizer
  ISSCR
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19543
[Presentation] ２型糖尿病原因遺伝子C2CD4Aの糖尿病発症メカニズム解明2022
- Author(s)
  中原有理、井上愛里、徳間啓、坂野大介、白木伸明、粂昭苑
- Organizer
  第45回分子生物学会
- Data Source
  KAKENHI-PROJECT-21H02978
[Presentation] Metabolic control of pluripotent stem cells in the generation of pancreatic endocrine beta cells2022
- Author(s)
  Shoen Kume
- Organizer
  第3 回JSRM-A*STARジョイントシンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02978
[Presentation] 膵β細胞におけるドーパミン生合成の役割とその制御機構の解明2022
- Author(s)
  板谷勇輝、上船史弥、徳間啓、富永成海、坂野大介、粂昭苑
- Organizer
  第45回分子生物学会
- Data Source
  KAKENHI-PROJECT-21H02978
[Presentation] 新規インスリン遺伝子変異を有するKumaマウスにおけるLC-MS/MSによる血漿中の代謝物プロファイルの解明2022
- Author(s)
  Naoya Hiyoshi, Takayuki Enomoto, Airi Inoue, Yusuke Kato, Daisuke Sakano, Kimi Araki, Nobuaki Shiraki, Shoen Kume
- Organizer
  第45回分子生物学会
- Data Source
  KAKENHI-PROJECT-21H02978
[Presentation] 新規インスリン遺伝子変異を有するKumaマウスにおけるLC-MS/MSによる血漿中の代謝物プロファイルの解明2022
- Author(s)
  Naoya Hiyoshi, Takayuki Enomoto, Airi Inoue, Yusuke Kato, Daisuke Sakano, Kimi Araki, Nobuaki Shiraki, Shoen Kume
- Organizer
  第45回分子生物学会
- Data Source
  KAKENHI-PROJECT-22K19543
[Presentation] ヒトiPS細胞由来膵島の作成とインスリン分泌の制御機構解明2022
- Author(s)
  粂昭苑
- Organizer
  第95回日本内分泌学会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19543
[Presentation] メチオニン制限を組み込んだ新規iPS細胞膵臓分化方法の開発2022
- Author(s)
  金子知代、島慧理果　榎本孝幸、白木伸明、粂昭苑
- Organizer
  アミノ酸学会
- Data Source
  KAKENHI-PROJECT-22K19543
[Presentation] ヒトiPS細胞由来膵島の作成とインスリン分泌の制御機構解明2022
- Author(s)
  粂昭苑
- Organizer
  第95回日本内分泌学会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02978
[Presentation] Generation of functional pancreatic beta cells derived from human induced pluripotent Stem Cell-with physiological cell culture medium2022
- Author(s)
  Kato Y, Shiraki N, Kume S.
- Organizer
  ISSCR
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19543
[Presentation] Generation of induced pluripotent Stem Cell-Derived Beta cells in Blood Amino Acids-Like Medium2022
- Author(s)
  Marwa san, Y Kato, Shiraki N, Kume S.
- Organizer
  22nd IUNS-InternationalCongress of Nutrition.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19543
[Presentation] メチオニン制限を組み込んだ新規iPS細胞膵臓分化方法の開発2022
- Author(s)
  金子知代、島慧理果　榎本孝幸、白木伸明、粂昭苑
- Organizer
  アミノ酸学会
- Data Source
  KAKENHI-PROJECT-21H02978
[Presentation] ２型糖尿病原因遺伝子C2CD4Aの糖尿病発症メカニズム解明2022
- Author(s)
  中原有理、井上愛里、徳間啓、坂野大介、白木伸明、粂昭苑
- Organizer
  第45回分子生物学会
- Data Source
  KAKENHI-PROJECT-22K19543
[Presentation] Metabolic control of pluripotent stem cells in the generation of pancreatic endocrine beta cells2022
- Author(s)
  Shoen Kume
- Organizer
  第3 回JSRM-A*STARジョイントシンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19543
[Presentation] 膵β細胞におけるドーパミン生合成の役割とその制御機構の解明2022
- Author(s)
  板谷勇輝、上船史弥、徳間啓、富永成海、坂野大介、粂昭苑
- Organizer
  第45回分子生物学会
- Data Source
  KAKENHI-PROJECT-22K19543
[Presentation] メチオニン除去培養によるエピジェネティック変化を伴うヒトiPS細胞分化促進2021
- Author(s)
  小澤弘樹、神戸梓沙、日比滉大、及川彰、藤木克則、白髭克彦、木村宏、白木伸明、粂昭苑
- Organizer
  第44回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21H02978
[Presentation] ヒトiPS細胞を用いた糖尿病の再生医療研究2021
- Author(s)
  粂　昭苑
- Organizer
  第20回日本再生医療学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02861
[Presentation] ヒトiPS細胞からの膵島作成とモデル細胞としての利用2021
- Author(s)
  粂昭苑
- Organizer
  第94回日本内分泌学会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21H02978
[Presentation] ヒト多能性幹細胞を用いた糖尿病の再生医療2021
- Author(s)
  粂昭苑
- Organizer
  第64回日本糖尿病学会年次学術集
- Invited
- Data Source
  KAKENHI-PROJECT-21H02978
[Presentation] 膵β細胞におけるD1-D2ヘテロ多量体を介したドーパミンによるインスリン分泌抑制機構の解明2021
- Author(s)
  上船史弥、坂野大介、青西亨、高橋晴美、清野進、粂昭苑
- Organizer
  第44回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21H02978
[Presentation] ドパミンによる膵臓発生機構の解明2021
- Author(s)
  井上愛里、下道隆広、坂野大介、粂昭苑
- Organizer
  第44回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21H02978
[Presentation] Metabolic control of pluripotent stem cells for the generation of pancreatic beta-cells2021
- Author(s)
  Shoen Kume, Erinn Zixuan Sim, Takayuki Enomoto, Nobuaki Shiraki.
- Organizer
  ISSCR /JSRM International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02978
[Presentation] 膵島移植に用いるための免疫隔離カプセルの評価2021
- Author(s)
  滝波那拓、榎本孝幸、白木伸明、粂昭苑
- Organizer
  第20回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-18H02861
[Presentation] WFS1の発現低下とインスリン分泌の関連性の解明2021
- Author(s)
  徳間啓坂野大介粂昭苑
- Organizer
  第44回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21H02978
[Presentation] 多能性幹細胞の維持と膵臓β細胞分化における亜鉛シグナルの関与2021
- Author(s)
  粂昭苑
- Organizer
  日本亜鉛栄養治療研究会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02978
[Presentation] アミノ酸の代謝を活用したiPS細胞の分化誘導系の構築2021
- Author(s)
  粂昭苑
- Organizer
  ICAAS 「アミノ酸セミナー・基礎と臨床を結ぶ会」
- Invited
- Data Source
  KAKENHI-PROJECT-21H02978
[Presentation] ヒト多能性幹細胞を用いた膵島再生研究2020
- Author(s)
  粂　昭苑
- Organizer
  日本動物細胞工学会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02861
[Presentation] マウス膵内分泌細胞のVMAT2による膵島の機能制御2020
- Author(s)
  芝江柾葵, 上船史弥, 坂野大介, 粂昭苑
- Organizer
  分子生物学会
- Data Source
  KAKENHI-PROJECT-18H02861
[Presentation] メチオニン代謝による幹細胞制御、および膵臓β細胞分化に与える影響2020
- Author(s)
  粂昭苑
- Organizer
  分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02861
[Presentation] Insulin supplement is essential in differentiating human induced pluripotent stem cells into pancreatic beta cells2019
- Author(s)
  Erinn Zixuan Sim, Nobuaki Shiraki, ShoenKume
- Organizer
  ISSCR
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02861
[Presentation] 多能性幹細胞から膵臓β細胞への分化誘導研究2019
- Author(s)
  粂昭苑
- Organizer
  糖尿病と再生医療フォーラム in Nagoya
- Invited
- Data Source
  KAKENHI-PROJECT-16K01362
[Presentation] 多能性幹細胞を用いた膵臓β細胞の再生研究2019
- Author(s)
  粂昭苑
- Organizer
  臨床医が知っておくべき糖尿病の基礎第５３回糖尿病学の進歩
- Invited
- Data Source
  KAKENHI-PROJECT-16K01362
[Presentation] メチオニン代謝による多能性幹細胞の分化制御2019
- Author(s)
  粂　昭苑
- Organizer
  第42回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02861
[Presentation] Improvement of pancreatic βcells differentiation from human iPS cells, especially for maturation and expansion2019
- Author(s)
  Marie Ono, Daisuke Sakano, Yuki Toyoda, Sai Araki, Shoen Kume
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H02861
[Presentation] Present status for the generation of pluripotent stem cell-derived pancreatic beta cells for the treatment of diabetes2019
- Author(s)
  Shoen Kume
- Organizer
  The Diabetes and Obesity in the region
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02861
[Presentation] ヒトiPS細胞から膵臓β細胞への分化誘導の技術開発2018
- Author(s)
  粂　昭苑
- Organizer
  日本糖尿病学会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02861
[Presentation] 多能性幹細胞から膵臓β細胞への分化誘導研究2018
- Author(s)
  粂　昭苑
- Organizer
  糖尿病と再生医療フォーラム in Nagoya
- Invited
- Data Source
  KAKENHI-PROJECT-18H02861
[Presentation] メチオニン除去培養によるヒトiPS細胞分化促進の機序解明2018
- Author(s)
  日比滉大, 秋山智彦，洪実，白木伸明, 粂昭苑
- Organizer
  第41回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-18H02861
[Presentation] Insulin2タンパクへのQ104del変異導入による自然発症１型糖尿病モデルマウスの作製2018
- Author(s)
  Airi Inoue, Daisuke Sakano, Takayuki Enomoto, Mai Imasaka, Seiji Okada, Kimi Araki, Shoen Kume
- Organizer
  第41回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-18H02861
[Presentation] Insulin supplement is essential in differentiationg human induced pluripotent stem cells into pancreatic beta cells.2018
- Author(s)
  Erinn Sim Zixuan, Nobuaki Shiraki, Shoen Kume
- Organizer
  The 16th Asia-Ocenia Congress of Endocrinology 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02861
[Presentation] 多能性幹細胞から膵β細胞への分化制御2018
- Author(s)
  粂　昭苑
- Organizer
  第91回日本内分泌学会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02861
[Presentation] Insulin supplement is essential in differentiationg human induced pluripotent stem cells into pancreatic beta cells.2018
- Author(s)
  Erinn Sim Zixuan, Nobuaki Shiraki, Shoen Kume
- Organizer
  The 16th Asia-Oceania Congress of Endocrinology 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01362
[Presentation] メチオニン除去培地とコラーゲンビトリゲル薄膜を用いて分化誘導したヒトiPS細胞由来肝臓細胞を利用した薬物毒性試験系の構築2018
- Author(s)
  柴田伊真,下道隆広, 渡邊輝彦, 山口宏之, 白木伸明, 粂昭苑
- Organizer
  細胞アッセイ研究会
- Data Source
  KAKENHI-PROJECT-18H02861
[Presentation] 多能性幹細胞から膵β細胞への分化誘導と再生医療への展望2018
- Author(s)
  粂昭苑
- Organizer
  第7回日本マーモセット研究会
- Invited
- Data Source
  KAKENHI-PROJECT-16K01362
[Presentation] 多能性幹細胞の未分化性維持と分化制御の分子基盤2018
- Author(s)
  粂昭苑
- Organizer
  第４１回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-16K01362
[Presentation] Generation of pancreatic beta cells from human iPS cells2018
- Author(s)
  Shoen Kume
- Organizer
  The 16th Asia-Ocenia Congress of Endocrinology 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02861
[Presentation] 多能性幹細胞を用いた膵臓β細胞の再生研究2018
- Author(s)
  粂　昭苑
- Organizer
  第53回糖尿病学の進歩
- Invited
- Data Source
  KAKENHI-PROJECT-18H02861
[Presentation] Generation of pancreatic beta cells from human iPS cells2018
- Author(s)
  Shoen Kume
- Organizer
  The 16th Asia-Oceania Congress of Endocrinology 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01362
[Presentation] Insulin2 タンパクへのQ104del変異導入による自然発症１型糖尿病モデルマウスの作製2018
- Author(s)
  Airi Inoue, Daisuke Sakano, Takayuki Enomoto, Mai Imasaka, Seiji Okada, Kimi Araki, Shoen Kume
- Organizer
  第４１回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-16K01362
[Presentation] メチオニン除去培養によるヒトiPS細胞分化促進の機序解明2018
- Author(s)
  日比滉大、秋山智彦、洪実、白木伸明、粂昭苑
- Organizer
  第４１回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-16K01362
[Presentation] 多能性幹細胞の未分化性維持と分化制御の分子基盤2018
- Author(s)
  粂　昭苑
- Organizer
  第41回日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02861
[Presentation] Insulin2 Q104del (Kuma) mutant mice develop diabetes with dominant inheritance2018
- Author(s)
  Sakano D,Inoue A, Enomoto T, Imasaka M, Okada S, Araki K, Kume S
- Organizer
  Joint Meeting of JSCB 70th & JSDB 51st
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02861
[Presentation] 代謝による多能性幹細胞の分化制御2018
- Author(s)
  粂　昭苑
- Organizer
  第6回がんと代謝研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02861
[Presentation] Chemical and metabolic control of pluripotent stem cell differentiation into pancreatic βcells2017
- Author(s)
  Shoen Kume
- Organizer
  GRE External seminar, Dundee University. Department of Life Sciences and Technology
- Invited
- Data Source
  KAKENHI-PROJECT-16K01362
[Presentation] モノアミンによるヒト膵β細胞分化および成熟化の調節機能を解明2017
- Author(s)
  豊田悠暉、荒木菜、坂野大介、粂昭苑
- Organizer
  2017年度生命科学系学会合同年次大会Consortium of Biological Sciences 2017
- Data Source
  KAKENHI-PROJECT-16K01362
[Presentation] 多能性幹細胞から膵β細胞への分化誘導シグナル2017
- Author(s)
  粂昭苑
- Organizer
  第3回生体調節研究所内分泌代謝シンポジウム-ゲノムとエピゲノムの交差点（課題）シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-16K01362
[Presentation] Generation of insulin-producing β-like cells from human iPS cell2016
- Author(s)
  Shoen Kume
- Organizer
  11th IDF WPR & 8th AASD meeting
- Place of Presentation
  Taipei
- Year and Date
  2016-10-28
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] 多能性幹細胞から膵臓β細胞を創る2016
- Author(s)
  粂　昭苑
- Organizer
  「細胞を創る」研究会9.0
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] モノアミンによるインスリン分泌制御機構の解明2016
- Author(s)
  上船史弥、園田雄輝、坂野大介、粂昭苑
- Organizer
  分子生物学会
- Place of Presentation
  横浜市
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] 多能性幹細胞を用いた糖尿病の再生治療のアプローチ2016
- Author(s)
  粂昭苑
- Organizer
  第43回日本膵・膵島移植研究会
- Place of Presentation
  広島市
- Year and Date
  2016-03-04
- Invited
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] Monoamine signals that control differentiation and proliferation of pancreatic beta cells.2016
- Author(s)
  Shoen Kume
- Organizer
  CDB symposium
- Place of Presentation
  神戸
- Year and Date
  2016-03-28
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] ヒトiPS細胞由来膵臓細胞を用いた膵臓β細胞分化を促進する化合物の探索2016
- Author(s)
  白木伸明、師岡茉由、白濱理絵、山下智大、粂昭苑
- Organizer
  日本薬学会135年会
- Place of Presentation
  神戸
- Year and Date
  2016-03-26
- Invited
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] ヒトiPS細胞におけるメチオニン代謝とヒストン修飾の役割の解明2016
- Author(s)
  神戸梓沙、白木伸明、木村宏、粂昭苑
- Organizer
  分子生物学会
- Place of Presentation
  横浜市
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] 多能性幹細胞を用いた糖尿病の再生・創薬研究2016
- Author(s)
  粂昭苑
- Organizer
  国立国際医療研究センター研究所セミナー
- Place of Presentation
  東京
- Year and Date
  2016-02-22
- Invited
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] Pluripotent stem cells for modeling cellular biology, developmental biology and regenerative medicine2016
- Author(s)
  Shoen Kume
- Organizer
  第4回の生命理工国際シンポジウム
- Place of Presentation
  横浜
- Year and Date
  2016-01-13
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] 多能性幹細胞から膵臓β細胞を創る2016
- Author(s)
  粂　昭苑
- Organizer
  「細胞を創る」研究会9.0
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-16K01362
[Presentation] 多能性幹細胞の分化制御と代謝2016
- Author(s)
  粂昭苑
- Organizer
  細胞生物学会
- Place of Presentation
  京都
- Year and Date
  2016-06-15
- Invited
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] 未分化iPS細胞および分化課程における亜鉛の役割2016
- Author(s)
  古田　奈央、白木　伸明、荒川　哲大、粂　昭苑
- Organizer
  分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K01362
[Presentation] 多能性幹細胞を用いた膵β細胞の再生医療への展望2016
- Author(s)
  粂昭苑
- Organizer
  千葉次世代糖尿病治療研究会
- Place of Presentation
  千葉市
- Year and Date
  2016-01-14
- Invited
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] ヒトES/iPS細胞の未分化能維持と分化におけるメチオニン代謝2016
- Author(s)
  白木伸明　粂　昭苑
- Organizer
  第15回日本再生医療学会総会
- Place of Presentation
  横浜
- Year and Date
  2016-03-19
- Invited
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] Generation of insulin-producing β-like cells from human iPS cells2016
- Author(s)
  Shoen Kume
- Organizer
  "Stem cell therapy"11th IDF WPR $ 8th AASD meeting
- Place of Presentation
  Taipei
- Year and Date
  2016-10-28
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01362
[Presentation] 幹細胞の未分化維持及び分化におけるメチオニン代謝の役割2016
- Author(s)
  門馬紗英子、白木伸明、及川彰、粂昭苑
- Organizer
  細胞生物学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] Generation of insulin-producing β-like cells from human iPS cells2016
- Author(s)
  Shoen Kume
- Organizer
  10th International Conference on Cell Therapy (IRICT)
- Place of Presentation
  Seoul
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] 多能性幹細胞を使った消化器官の再生医療への取組み2016
- Author(s)
  粂昭苑
- Organizer
  第19回再生医療の実用化に関するニーズ発表会
- Place of Presentation
  神戸
- Year and Date
  2016-02-12
- Invited
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] 多能性幹細胞から膵β細胞への分化誘導2016
- Author(s)
  粂昭苑
- Organizer
  第15回日本再生医療学会総会
- Place of Presentation
  大阪
- Year and Date
  2016-03-17
- Invited
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] 多能性幹細胞を用いた肝と膵の再生医学研究2015
- Author(s)
  粂昭苑
- Organizer
  第22回肝細胞研究会
- Place of Presentation
  米子
- Year and Date
  2015-06-04
- Invited
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] iPS細胞を用いた再生医療2015
- Author(s)
  粂昭苑
- Organizer
  第27回福岡糖尿病アゴラ
- Place of Presentation
  福岡市
- Year and Date
  2015-04-18
- Invited
- Data Source
  KAKENHI-PROJECT-26670384
[Presentation] 多能性幹細胞を用いた消化器官の分化誘導研究2015
- Author(s)
  粂昭苑
- Organizer
  第4回細胞治療研究会
- Place of Presentation
  東京都
- Year and Date
  2015-10-31
- Invited
- Data Source
  KAKENHI-PROJECT-26670384
[Presentation] 膵β細胞の複製を促進する低分子化合物の探索2015
- Author(s)
  坂野大介・崔　成翼・片岡正光・粂昭苑
- Organizer
  BMB2015
- Place of Presentation
  横浜
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] 多能性幹細胞を応用した膵β細胞の再生治療2015
- Author(s)
  粂昭苑
- Organizer
  第67回糖尿病血管障害講演会
- Place of Presentation
  東京都
- Year and Date
  2015-06-17
- Invited
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] 多能性幹細胞を用いた膵β細胞の再生治療2015
- Author(s)
  粂昭苑
- Organizer
  第15回Islet Biology 研究会
- Place of Presentation
  東京都
- Year and Date
  2015-07-17
- Invited
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] 多能性幹細胞の多能性維持および分化におけるアミノ酸およびその誘導体の役割2015
- Author(s)
  粂昭苑
- Organizer
  BMB2015
- Place of Presentation
  横浜
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] ES/iPS細胞を用いた糖尿病の創薬研究2015
- Author(s)
  粂昭苑
- Organizer
  Bio Japan
- Place of Presentation
  横浜
- Year and Date
  2015-10-15
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] 膵β細胞の複製を促進する低分子化合物の探索2014
- Author(s)
  坂野大介、崔　成翼、片岡正光、粂昭苑
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] Signals that control differentiation of pluripotent stem cells into pancreatic beta cells2014
- Author(s)
  Shoen Kume
- Organizer
  Tissue Engineering Regenerative Medicine International Society (TERMIS-EU 2014)
- Place of Presentation
  Genova
- Year and Date
  2014-06-10
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] Chemical genetic identification of signals that control late-stage pancreatic beta cell differentiation2014
- Author(s)
  Shoen Kume
- Organizer
  ISSCR (International Society of Stem Cell Research)
- Place of Presentation
  Vancouber
- Year and Date
  2014-06-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] 多能性幹細胞モデルを用いた膵臓の発生分化研究2014
- Author(s)
  粂　昭苑
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-16
- Invited
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] Chemical genetic identification of signals that control late-stage pancreatic beta cell differentiation.2014
- Author(s)
  Shoen Kume
- Organizer
  ISSCR
- Place of Presentation
  ボストン
- Year and Date
  2014-06-20
- Data Source
  KAKENHI-PROJECT-26670384
[Presentation] S-adenosyl methionine is crucial for maintaining human ES/ iPS cells2014
- Author(s)
  Tsuyama T, Shiraki N, Kume S.
- Organizer
  Key Forum
- Place of Presentation
  Kumamoto
- Year and Date
  2014-09-05
- Data Source
  KAKENHI-PROJECT-26670384
[Presentation] 再生医療を用いた糖尿病治療の今後の展望2014
- Author(s)
  粂昭苑
- Organizer
  日本内分泌学会学術総会
- Place of Presentation
  福岡
- Year and Date
  2014-04-25
- Invited
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] Methionine metabolism regulates maintenance and differentiation of human pluripotent stem cells2014
- Author(s)
  Nobuaki Shiraki and Shoen Kume
- Organizer
  Key Forum: From Stem Cells to Organs
- Place of Presentation
  Kumamoto
- Year and Date
  2014-09-04
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] ヒト多能性幹細胞の未分化維持および分化におけるメチオニン代謝の役割2014
- Author(s)
  白木伸明, 白木恭子, 津山友徳, 小幡史明, 三浦正幸, 永江玄太, 油谷浩幸, 粂和彦, 遠藤文夫, 粂昭苑
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] Signals that control differentiation of pluripotent stem cells into pancreatic beta cells2014
- Author(s)
  Shoen Kume
- Organizer
  Tissue Engineering Regenerative Medicine International Society
- Place of Presentation
  ジェノバー
- Year and Date
  2014-06-12
- Invited
- Data Source
  KAKENHI-PROJECT-26670384
[Presentation] A cost effective intestinal epithelial differentiation system from human iPS cells2014
- Author(s)
  4)Ogaki S., Morooka M, Otera K and Kume S.
- Organizer
  Key Forum
- Place of Presentation
  Kumamoto
- Year and Date
  2014-09-05
- Data Source
  KAKENHI-PROJECT-26670384
[Presentation] Signals that control differentiation of ES/iPS cells into pancreatic beta cells2014
- Author(s)
  Shoen Kume
- Organizer
  The 8th International Conference on Cell Therapy
- Place of Presentation
  Seoul
- Year and Date
  2014-10-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] iPS技術を用いた膵β細胞の分化誘導研究2014
- Author(s)
  粂　昭苑
- Organizer
  第29回日本糖尿病合併症学会
- Place of Presentation
  東京都
- Year and Date
  2014-10-04
- Invited
- Data Source
  KAKENHI-PROJECT-26253059
[Presentation] Easy purification of human iPSC-derived immature intestinal epithelial cells2014
- Author(s)
  Otera K, Ogaki S, Kume S.
- Organizer
  Key Forum
- Place of Presentation
  Kumamoto
- Year and Date
  2014-09-05
- Data Source
  KAKENHI-PROJECT-26670384
[Presentation] Epiplakin1 (EPPk1) is expressed in foregut endoderm, also novel marker for adult progenitor cells in injured liver.2011
- Author(s)
  Akira Matsuo, Tetsu Yoshida, Rika Miki, Kazuhiko Kume, Shoen Kume
- Organizer
  Keystone Symposia on Molecular and cellular biology
- Place of Presentation
  Hilton Santa Fe/Historic Plaza (Santa Fe, New Mexico.)
- Year and Date
  2011-02-10
- Data Source
  KAKENHI-PROJECT-21390280
[Presentation] Generation of intestinal epithelial like cell derived from ES cells2010
- Author(s)
  Ogaki, S., Shiraki, N., Kume, K., Kume, S.
- Organizer
  第33回分子生物学会
- Place of Presentation
  国際会議場〔神戸市〕
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21390280
[Presentation] Regeneration of beta cells in neonatal mouse after streptozotocin treatment2010
- Author(s)
  Kawamura Y, Miki R, Yasukawa T, Yoshida T, Shiraki N, Kume K, Kume S
- Organizer
  第33回分子生物学会
- Place of Presentation
  国際会議場〔神戸市〕
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21390280
[Presentation] Epiplakin1 (Eppk1) marks the cholangiocytes and transit amplifying cells in injured liver2010
- Author(s)
  Matsuo A, Yoshida T, Miki R, Fujiwara S, Kume, K., Kume, S.
- Organizer
  第33回分子生物学会
- Place of Presentation
  国際会議場〔神戸市〕
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21390280
[Presentation] ES/iPS細胞から膵細胞系譜への分化誘導2010
- Author(s)
  粂昭苑
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山コンベンションセンター(岡山市)
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-21390280
[Presentation] Efficient differentiation of mouse and human ES/iPS cells into hepatic cells using feeder free basement membrane substratum.2010
- Author(s)
  Shiraki N., Zeng Q., Mochitate K., Higuchi Y., Umeda K., Kume K., Kume S.
- Organizer
  第33回分子生物学会
- Place of Presentation
  国際会議場〔神戸市〕
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21390280
[Presentation] The effects of amino acids on the differentiation of mouse embryonic stem cells into hepatic lineages.2010
- Author(s)
  Shiraki Y., Shiraki N., Mochida T., Kume S., Endo F
- Organizer
  第33回分子生物学会
- Place of Presentation
  国際会議場〔神戸市〕
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21390280
[Presentation] Guiding ES/iPS cells to differentiate into pancreatic beta cells2010
- Author(s)
  粂昭苑
- Organizer
  第43回発生生物学会
- Place of Presentation
  京都国際会議場(京都市)
- Year and Date
  2010-06-23
- Data Source
  KAKENHI-PROJECT-21390280
[Presentation] 人工基底膜を用いたES細胞から肝細胞への分化誘導2010
- Author(s)
  白木伸明, 樋口裕一郎, 山添太士, 曾勤, 持立克身, 小林直哉, 粂和彦, 粂昭苑
- Organizer
  第9回日本再生医療学会総会シンポジウム「肝移植・再生」
- Place of Presentation
  広島国際会議場(広島市)
- Year and Date
  2010-03-19
- Data Source
  KAKENHI-PROJECT-21390280
[Presentation] 膵臓・肝臓の再生医療と創薬への応用2010
- Author(s)
  粂昭苑
- Organizer
  Walk Again 2010再生医療シンポジウム
- Place of Presentation
  アクロス福岡・国際会議場(福岡市)
- Year and Date
  2010-07-25
- Data Source
  KAKENHI-PROJECT-21390280
[Presentation] ES/iPS細胞の分化誘導をサポートする細胞外環境の重要性2010
- Author(s)
  粂昭苑
- Organizer
  専門家と直接意見交換シンポジウム in KRP Part II
- Place of Presentation
  京都リサーチパーク(京都市)
- Year and Date
  2010-10-19
- Data Source
  KAKENHI-PROJECT-21390280
[Presentation] Analysis of Epiplakin1 expression during pancreatic regeneration2010
- Author(s)
  Miki R, Yoshida T, Shiraki N, Kume K, Kume S
- Organizer
  第33回分子生物学会
- Place of Presentation
  国際会議場〔神戸市〕
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21390280
[Presentation] Efficient differentiation of mouse and human ES/iPS cells into hepatic cells using feeder free basement membrane substratum.2010
- Author(s)
  Shiraki N., Zeng Q., Mochitate K., Higuchi Y., Umeda K., Kume K., Kume S.
- Organizer
  8^<th> ISSCR Annual Meeting
- Place of Presentation
  MOSCONE CENTER (San Francisco, USA)
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-21390280
[Presentation] A novel culture environment that promotes hepatic differentiation from human iPS and mouse ES cells.2010
- Author(s)
  Yamazoe, T., Shiraki, N., Umeda, K., Kume, K., Kume, S.
- Organizer
  第33回分子生物学会
- Place of Presentation
  国際会議場〔神戸市〕
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21390280
[Presentation] Epiplakin1 (Eppk1) marks the progenitor population in adult liver2010
- Author(s)
  Matsuo A, Yoshida T, Miki R, Fujiwara S, Kume, K.e, Kume, S.
- Organizer
  The 16th International Conference of the International society of Differentiation
- Place of Presentation
  市民会館(奈良市)
- Year and Date
  2010-11-18
- Data Source
  KAKENHI-PROJECT-21390280
[Presentation] The establishment of a screening system for low molecular compounds for β cell inducing activity2010
- Author(s)
  Sakano, D., Shiraki, N., Kataoka, M., Uesugi, M., Saya, H., Kume, K, Kume, S.
- Organizer
  第33回分子生物学会
- Place of Presentation
  国際会議場〔神戸市〕
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21390280
[Presentation] 幹細胞を用いた消化器官の発生再生研究2009
- Author(s)
  粂昭苑
- Organizer
  第33回阿蘇シンポジウム
- Place of Presentation
  阿蘇リゾートグランヴィリオホテル(阿蘇市)
- Year and Date
  2009-08-01
- Data Source
  KAKENHI-PROJECT-21390280
[Presentation] Novel differentiation procedures of the mouse ES or iPS cells into pancreatic cell lineages2009
- Author(s)
  Yuichiro Higuchi, Keitaro Yamane, Nobuaki Shiraki, Zeng Qin, Katsumi Mochitate, Kazuhiko Kume, Shoen Kume
- Organizer
  7^<th> ISSCR Annual Meeting
- Place of Presentation
  Centtre Convencion Internacional(バルセロナ、スペイン王国)
- Year and Date
  2009-07-08
- Data Source
  KAKENHI-PROJECT-21390280
[Presentation] ES・iPS細胞から消化器官細胞への分化誘導研究2009
- Author(s)
  粂昭苑
- Organizer
  第83回医工学フォーラム
- Place of Presentation
  京都大学再生医科学研究所(京都市)
- Year and Date
  2009-05-29
- Data Source
  KAKENHI-PROJECT-21390280
[Presentation] Efficient differentiation of mouse and human ES cells into hepatic cells using feeder free basement membrane substratum in vitro2009
- Author(s)
  Nobuaki Shiraki, Zeng Qin, Katsumi Mochitate, Yuichiro Higuchi, Kahoko Umeda, Kazuhiko Kume, Shoen Kume
- Organizer
  7^<th> ISSCR Annual Meeting
- Place of Presentation
  Centtre Convencion Internacional(バルセロナ、スペイン王国)
- Year and Date
  2009-07-08
- Data Source
  KAKENHI-PROJECT-21390280
[Presentation] ニワトリ胚における膵臓前駆細胞の起源と初期内胚葉領域化メカニズムについての解析2009
- Author(s)
  勝本恵一福田公子木村航嶋村健児八杉貞雄粂昭苑
- Organizer
  日本発生生物学会
- Place of Presentation
  朱鷺メッセ(新潟)
- Year and Date
  2009-05-30
- Data Source
  KAKENHI-PROJECT-20790652
[Presentation] The "sliding" between the endoderm and the mesoderm layer in the early embryo is a significant event for pancreas development2009
- Author(s)
  Keiichi Katsumoto, Kimiko Fukuda, Wataru Kimura, Kenji Shimamura, Sadao Yasugi, Shoen Kume
- Organizer
  International Society for Stem Cell Research
- Place of Presentation
  Barcelona (Spain)
- Year and Date
  2009-07-09
- Data Source
  KAKENHI-PROJECT-20790652
[Presentation] ES・iPS細胞から消化器官細胞への分化誘導研究2009
- Author(s)
  粂昭苑
- Organizer
  第49回先天異常学会
- Place of Presentation
  鹿児島市民文化ホール(鹿児島市)
- Year and Date
  2009-06-25
- Data Source
  KAKENHI-PROJECT-21390280
[Presentation] 幹細胞を用いた消化器官の再生医学研究2009
- Author(s)
  粂昭苑
- Organizer
  第112回日本小児科学会学術集会
- Place of Presentation
  奈良県文化会館(奈良市)
- Year and Date
  2009-04-17
- Data Source
  KAKENHI-PROJECT-21390280
[Presentation] ニワトリ胚における背側、腹側膵臓形成メカニズムの解析2009
- Author(s)
  勝本恵一松浦公美福田公子粂昭苑
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜(横浜)
- Year and Date
  2009-12-12
- Data Source
  KAKENHI-PROJECT-20790652
[Presentation] 幹細胞を用いた消化器官細胞への分化誘導2009
- Author(s)
  粂昭苑
- Organizer
  第15回大阪大学医療組織工学フォーラム
- Place of Presentation
  大阪大学(大阪市)
- Year and Date
  2009-12-01
- Data Source
  KAKENHI-PROJECT-21390280
[Presentation] Differentiation of ES cells into pancreatic and hepatic cells2009
- Author(s)
  粂昭苑
- Organizer
  ISREC seminar
- Place of Presentation
  Swiss Institute for Experimental Cancer Research(ローザンヌ、スイス連邦)
- Year and Date
  2009-07-14
- Data Source
  KAKENHI-PROJECT-21390280

1. KUME Kazuhiko (30251218)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
2. SHIRAKI Nobuaki (70448520)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
3. FUKUDA Kimiko (40285094)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. KATSUMOTO Keiichi (40398227)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
5. SHIMAMURA Kenji (70301140)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. YASUGI Sadao (70011591)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. ANDO Yukio (20253742)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. JONO Hirofumi (40515483)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. UEDA Mitsuharu (60452885)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YAMAZOE Taiji (20736219)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. SASAKI Yutaka (70235282)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Ando Yusuke (80712942)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 菊池裕 (20286438)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 横内裕二 (60252227)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 中越英樹 (50314662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 高橋淑子 (10183857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 荒木喜美 (90211705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. 井藤彰 (60345915)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. Nakaji Shuhei

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. Kobayashi Goro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. SAKANO Daisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
22. TANABE Katsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. SUZUKI Kentaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. TOMITA Jun

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 荒木正健

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 白髭克彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 小池正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 土屋輝一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 貝塚拓

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
30. 三浦正幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 葛原隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 山田源

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KUME Shoen 粂 昭苑

Research Projects

Research Products

Co-Researchers

Generation of iPS-derived beta cells with heterogeneityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Improvement of functionality by heterogeneity formation of the iPS-derived pancreatic beta cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the molecular mechanism regulating pancreatic islets using human pluripotent stem cell differentiation systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The mechanism for the maintenance of pancreatic beta cells derived by in vitro differentiation of human pluripotent stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research on innovative cell transplantation device using immunoisolation membrane

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The purification and expansion of human iPS cell-derived intestinal precursor cells for future application in regenerative medicinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of hepatic maturation mechanisms of human iPS cells by using chemical screening

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Generation of human iPS-derived pancreatic beta cells and its application towards regenerative medicinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Hepatocyte replacement therapy for familial amybidotic polyneuropathy combining iPS cells and gene-repair therapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

膵幹細胞の分化と維持の制御機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the pancreas regionalization factor in the pre-pancreas region.

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

消化器の形態形成に関わる遺伝子の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

試験管内ES細胞分化誘導系を用いた膵幹細胞の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

KUME Shoen 粂昭苑

[Book] 新膵臓病学　第２章膵の発生2017

[Book] 新膵臓病学第2章膵の発生2017