Saga Yasushi 嵯峨泰

… Alternative Names

嵯峨泰サガヤスシ

SAGA Yasushi 嵯峨泰

Less

Researcher Number	70360071
Other IDs
External Links
Affiliation (Current)	2025: 自治医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2017 – 2024: 自治医科大学, 医学部, 准教授 2015: 自治医科大学, 医学部, 准教授 2013: 自治医科大学, 医学部, 准教授 2009 – 2011: Jichi Medical University, 医学部, 講師 2007: Jichi Medical University, Department of Obstetrics and Gynecology, Lecturer 2003 – 2006: 自治医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Obstetrics and gynecology / Basic Section 56040:Obstetrics and gynecology-related Except Principal Investigator Obstetrics and gynecology
Keywords	Principal Investigator バソヒビン1 / 卵巣がん / アデノ随伴ウイルスベクター / パクリタキセル / シスプラチン / ビンクリスチン / イリノテカン / バソヒビン2 / バソヒビン / 一本鎖抗体 … More / ゲノム編集 / 抗がん剤感受性 / 血管新生 / バソヒビン２ / ジェムシタビン / アデノ随伴ウイルス / 腫瘍免疫 / インドールアミン酸素添加酵素 / 子宮頸がん / チューブリンカルボキシペプチダーゼ / 細胞周期 / 微小管 / SN38 / 抗がん剤 / HGF/NK4 / vasohibin-2 / vasohibin-1 / PI3K / AKT / c-Met / IDO / NK4 / PDGF / VEGF / VASH2 / VASH1 / 濃伝子治療 / 婦人性器がん / 婦人性器癌 / 腫瘍血管新生 / 遺伝子治療 / 分子標的治療 / 子宮体がん / GPX / HRA / GPX3 / DNAマイクロアレイ / 抗癌剤耐性 / glutathione peroxidase 3 / 卵巣明細胞癌 … More Except Principal Investigator basic Research / adeno-associated virus / gene therapy / molecular targeted thera / peritoneal dissemination / ovarian cancer / 基礎研究 / アデノ随伴ウイルス / 遺伝子治療 / 分子標的治療 / 腹膜播種 / 卵巣癌 Less

血管新生調節因子バソヒビン1搭載アデノ随伴ウイルスベクターによる新規卵巣がん治療Principal Investigator
- Principal Investigator
  
  嵯峨泰
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Jichi Medical University
バソヒビン2を標的とした卵巣がん新規治療に関する基礎研究Principal Investigator
- Principal Investigator
  
  嵯峨泰
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Jichi Medical University
Development of novel ovarian cancer therapy targeting angiogenesis and immune escape by the vasohibin familyPrincipal Investigator
- Principal Investigator
  
  Saga Yasushi
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Jichi Medical University
Ovarian cancer treatment targeting angiogenesis and immune tolerancePrincipal Investigator
- Principal Investigator
  
  Saga Yasushi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Jichi Medical University
Vasohibin, a novel regulator of angiogenesis, as a useful for molecular targeted therapy and gene therapy in gynecologic malignanciesPrincipal Investigator
- Principal Investigator
  
  SAGA Yasushi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Jichi Medical University
Molecular targeted and gene therapy using adeno-associated virus vector to suppress the peritoneal dissemination in ovarian cancer
- Principal Investigator
  
  OHWADA Michitaka
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Jichi Medical University
卵巣明細胞癌の抗癌剤耐性機序の解明と至適治療法の開発に関する研究Principal Investigator
- Principal Investigator
  
  嵯峨泰
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Jichi Medical University

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2006 2005

All Journal Article Presentation

[Journal Article] Knockout of vasohibin‐2 reduces tubulin carboxypeptidase activity and increases paclitaxel sensitivity in ovarian cancer2021
- Author(s)
  Koyanagi Takahiro、Saga Yasushi、Takahashi Yoshifumi、Tamura Kohei、Yoshiba Takahiro、Takahashi Suzuyo、Taneichi Akiyo、Takei Yuji、Urabe Masashi、Mizukami Hiroaki、Fujiwara Hiroyuki
- Journal Title
  
  Cancer Medicine
  
  Volume: 10 Issue: 8 Pages: 2732-2739
- DOI
  10.1002/cam4.3841
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11294, KAKENHI-PROJECT-20K09627, KAKENHI-PROJECT-19K18702
[Journal Article] CRISPR/Cas9-mediated cervical cancer treatment targeting human papillomavirus E62019
- Author(s)
  Yoshiba T, Saga Y, Urabe M, Uchibori R, Matsubara S, Fujiwara H, Mizukami H
- Journal Title
  
  Oncol Lett
  
  Volume: １７ Pages: 2197-2206
- DOI
  10.3892/ol.2018.9815
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11294
[Journal Article] AAV6-mediated IL-10 expression in the lung ameliorates bleomycin-induced pulmonary fibrosis in mice2018
- Author(s)
  Kurosaki F, Uchibori R, Sehara Y, Saga Y, Urabe M, Mizukami H, Hagiwara K, Kume A.
- Journal Title
  
  Hum Gene Ther
  
  Volume: - Issue: 11 Pages: 1242-1251
- DOI
  10.1089/hum.2018.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11294, KAKENHI-PROJECT-18K15932
[Journal Article] Eradication of cervical cancer in vivo by an AAV vector that encodes shRNA targeting human papillomavirus type 16 E6/E72018
- Author(s)
  Sato N, Saga Y, Uchibori R, Tsukahara T, Urabe M, Kume A, Fujiwara H, Suzuki M, Ozawa K, Mizukami H.
- Journal Title
  
  Int J Oncol
  
  Volume: 52 Pages: 687-696
- DOI
  10.3892/ijo.2018.4245
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11294
[Journal Article] Optimization of adeno-associated virus vector-mediated gene transfer to the respiratory tract2017
- Author(s)
  Kurosaki F, Uchibori R, Mato N, Sehara Y, Saga Y, Urabe M, Mizukami H, Sugiyama Y, Kume A.
- Journal Title
  
  Gene Ther
  
  Volume: 24 Issue: 5 Pages: 290-297
- DOI
  10.1038/gt.2017.19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11294
[Journal Article] The hepatocyte growth factor antagonist NK4 inhibits indoleamine-2,3-dioxygenase expression via the c-Met-phosphatidylinositol 3-kinase-AKT signaling pathway2016
- Author(s)
  Wang D, Saga Y, Sato N, Nakamura T, Takikawa O, Mizukami H, Matsubara S, Fujiwara H
- Journal Title
  
  Int J Oncol
  
  Volume: 48 Issue: 6 Pages: 2303-2309
- DOI
  10.3892/ijo.2016.3486
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462606, KAKENHI-PROJECT-15K08326
[Journal Article] Vasohibin-1 expression inhibits advancement of ovarian cancer producing various angiogenic factors2016
- Author(s)
  Takahashi Y, Saga Y, Koyanagi T, Takei Y, Machida S, Taneichi A, Mizukami H, Sato Y, Matsubara S, Fujiwara H
- Journal Title
  
  Cancer Sci
  
  Volume: 未定 Issue: 5 Pages: 629-637
- DOI
  10.1111/cas.12911
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25462606
[Journal Article] The angiogenesis regulator vasohibin-1 inhibits ovarian cancer growth and peritoneal dissemination and prolongs host survival2015
- Author(s)
  Takahashi Y, Saga Y, Koyanagi T, Takei Y, Machida S, Taneichi A, Mizukami H, Sato Y, Matsubara S, Fujiwara H
- Journal Title
  
  Int J Oncol
  
  Volume: 47 Issue: 6 Pages: 2057-2063
- DOI
  10.3892/ijo.2015.3193
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25462606
[Journal Article] Suppression of lymph node and lung metastases of endometrial cancer by muscle-mediated expression of soluble VEGF receptor-32013
- Author(s)
  Takahashi K, Mizukami H, Saga Y, Takei Y, Urabe M, Kume A, Machida S, Fujiwara H, Suzuki M, Ozawa K
- Journal Title
  
  Cancer Science
  
  Volume: 104 Issue: 8 Pages: 1107-1111
- DOI
  10.1111/cas.12184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591548, KAKENHI-PROJECT-24390247, KAKENHI-PROJECT-25462606
[Journal Article] In vivo delivery of siRNA targeting vasohibin-2 decreases tumor angiogenesis and suppresses tumor growth in ovarian cancer2013
- Author(s)
  Koyanagi T, Suzuki Y, Saga Y, Machida S, Takei Y, Fujiwara H, Suzuki M, Sato Y
- Journal Title
  
  Cancer Sci
  
  Volume: 104 Issue: 1 Pages: 1705-1710
- DOI
  10.1016/j.ando.2014.01.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462606
[Journal Article] Is a peritoneal cytology a prognostic factor of endometrial cancer confined to the uterus2006
- Author(s)
  Saga Y, et. al.
- Journal Title
  
  Gynecol Oncol 103
  
  Pages: 277-280
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591755
[Journal Article] Is peritoneal cytology a prognostic factor of endometrial cancer confined to the uterus?2006
- Author(s)
  Saga Y.
- Journal Title
  
  Gynecol Oncol 103
  
  Pages: 277-280
- Data Source
  KAKENHI-PROJECT-17591755
[Journal Article] Is peritoneal cytology a prognostic factor of endometrial cancer confined to the uterus?2006
- Author(s)
  Saga Y, et. al.
- Journal Title
  
  Gynecol Oncol 103
  
  Pages: 277-280
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591755
[Journal Article] 卵巣明細胞癌を考える-抗悪性腫瘍感受性は本当に低いのか?- 産科と婦人科2005
- Author(s)
  嵯峨泰
- Journal Title
  
  産科と婦人科 72巻・5号(未定)
- Data Source
  KAKENHI-PROJECT-15790905
[Presentation] 卵巣がん細胞株におけるバソヒビン2ノックアウトはパクリタキセル感受性を増強させる2020
- Author(s)
  小柳貴裕、嵯峨　泰、高橋詳史、葭葉貴弘、高橋寿々代、町田静生、種市明代、竹井裕二、藤原寛行
- Organizer
  第72回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-17K11294
[Presentation] 16型ヒトパピローマウイルスE6のCRISPR/Cas9によるノックアウトは子宮頸がんのバソヒビン2発現を抑制する2019
- Author(s)
  葭葉貴弘、嵯峨　泰、小柳貴裕、高橋詳史、高橋寿々代、森澤宏行、町田静生、種市明代、竹井裕二、藤原寛行、松原茂樹
- Organizer
  第71回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-17K11294
[Presentation] CRISPR/Cas9によるバソヒビン2ノックアウトは子宮頸がん細胞のパクリタキセル感受性を増強させる2019
- Author(s)
  小柳貴裕、嵯峨　泰、高橋詳史、葭葉貴弘、高橋寿々代、森澤宏行、町田静生、種市明代、竹井裕二、藤原寛行、松原茂樹
- Organizer
  第71回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-17K11294
[Presentation] 血管新生調節因子バソヒビン1は免疫抑制酵素であるインドールアミン酸素添加酵素発現を低下させて卵巣がんの腫瘍免疫寛容を抑制する2018
- Author(s)
  嵯峨　泰、高橋詳史、小柳貴裕、葭葉貴弘、高橋寿々代、森澤宏行、町田静生、種市明代、竹井裕二、藤原寛行、松原茂樹
- Organizer
  日本産科婦人科学会
- Data Source
  KAKENHI-PROJECT-17K11294
[Presentation] Vasohibin-1は卵巣癌細胞のインドール酸素添加酵素発現の抑制を介して腫瘍免疫寛容を阻害する2014
- Author(s)
  嵯峨　泰、高橋詳史、小柳貴裕、鈴木光明、佐藤靖史
- Organizer
  第9回Vasohibin研究会
- Place of Presentation
  蔵王
- Data Source
  KAKENHI-PROJECT-25462606
[Presentation] 新規血管新生調節因子バゾヒビン2中和抗体の開発と卵巣癌治療応用に向けての基礎研究2014
- Author(s)
  小柳貴裕、嵯峨　泰、高橋詳史、佐藤尚人、町田静生、種市明代、竹井裕二、藤原寛行、
- Organizer
  第66回日本産科婦人科学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25462606
[Presentation] 卵巣癌細胞が産生する新規血管新生調節因子Vasohibin‐2を標的とした治療法の開発2013
- Author(s)
  小柳貴裕、嵯峨　泰、高橋詳史、佐藤尚人、高橋寿々代、町田静生、種市明代、竹井裕二、藤原寛行、鈴木光明
- Organizer
  第52回日本臨床細胞学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-25462606
[Presentation] 新規腫瘍血管新生因子バソヒビン2を標的とした婦人科がん分子標的治療2013
- Author(s)
  小柳貴裕、嵯峨　泰、高橋詳史、藤原寛行、鈴木光明
- Organizer
  第65回日本産科婦人科学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-25462606
[Presentation] 肝細胞増殖因子(HGF)のアンタゴニストHGF/NK4はcMet-PI3K-AKT経路を介してインドール酸素添加酵素（IDO）の発現を抑制し卵巣癌の免疫寛容を低下させる2013
- Author(s)
  嵯峨　泰、佐藤尚人、高橋詳史、小柳貴裕、種市明代、町田静生、竹井祐二、藤原寛行、鈴木光明
- Organizer
  第65回日本産科婦人科学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-25462606
[Presentation] Vasohibin-1の卵巣癌への効果とその機序に関する研究2012
- Author(s)
  嵯峨泰
- Organizer
  第7回Vasohibin研究会
- Place of Presentation
  東北大学加齢医学研究所国際会議場
- Year and Date
  2012-02-20
- Data Source
  KAKENHI-PROJECT-21592143
[Presentation] 卵巣癌細胞に対する血管新生ネガティブフィードバック調整因子バソヒビン1の効果2011
- Author(s)
  嵯峨泰
- Organizer
  第52回日本臨床細胞学会総会
- Place of Presentation
  福岡市
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-21592143
[Presentation] 卵巣癌細胞に対する血管新生ネガティブフィードバック調整因子バソヒビン1の効果2011
- Author(s)
  嵯峨泰
- Organizer
  第52回日本臨床細胞学会総会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-21592143
[Presentation] Expression of vasohibin-1 in ovarian cancer cells suppresses intraperitoneal dissemination and extends host survival2010
- Author(s)
  嵯峨泰
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪市
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21592143
[Presentation] Expression of vasohibin-1 in ovarian cancer cells suppresses intraperitoneal dissemination and extends host survival2010
- Author(s)
  嵯峨泰
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21592143
[Presentation] 子宮体癌の悪性度に関わる新しい因子に関する分子細胞生物学的検討2010
- Author(s)
  嵯峨泰
- Organizer
  第49回日本臨床細胞学会秋期大会
- Place of Presentation
  神戸ポートピアホテル
- Year and Date
  2010-11-22
- Data Source
  KAKENHI-PROJECT-21592143
[Presentation] VEGFまたはPDGFを産生する卵巣癌に対する血管新生ネガティブフィードバック調整因子バソヒビン1の効果2010
- Author(s)
  嵯峨泰
- Organizer
  第9回日本婦人科がん分子標的研究会学術集会
- Place of Presentation
  大津プリンスホテル
- Year and Date
  2010-09-10
- Data Source
  KAKENHI-PROJECT-21592143
[Presentation] VEGFまたはPDGFを産生する卵巣癌に対する血管新生ネガティブフィードバック調整因子バソヒビン1の効果2010
- Author(s)
  嵯峨泰
- Organizer
  第9回日本婦人科がん分子標的研究会学術集会
- Place of Presentation
  大津市
- Year and Date
  2010-09-10
- Data Source
  KAKENHI-PROJECT-21592143
[Presentation] Glutathione peroxidase(GPX 3)は卵巣明細胞腺癌の抗癌剤耐性に関与する2006
- Author(s)
  嵯峨泰, 他
- Organizer
  第58回日本産科婦人科学会総会
- Place of Presentation
  横浜市
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591755
[Presentation] Gene therapy and molecular targeted therapy to inhibition of angiogenesis in ovarian cancer2005
- Author(s)
  Saga, et. al.
- Organizer
  64th Annual meeting of Japan Society of Cancer
- Place of Presentation
  Sapporo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591755
[Presentation] 進行卵巣癌に対する血管新生抑制を標的とした遺伝子および秀子標的治療に関する基礎研究2005
- Author(s)
  嵯峨泰, 他
- Organizer
  第64回日本癌学会総会
- Place of Presentation
  札幌市
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591755

1. OHWADA Michitaka (40203955)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. SUZUKI Mitsuaki (50110870)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. OZAWA Keiya (30137707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 久米晃啓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Saga Yasushi 嵯峨 泰

嵯峨 泰 サガ ヤスシ

SAGA Yasushi 嵯峨 泰

Research Projects

Research Products

Co-Researchers

血管新生調節因子バソヒビン1搭載アデノ随伴ウイルスベクターによる新規卵巣がん治療Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

バソヒビン2を標的とした卵巣がん新規治療に関する基礎研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel ovarian cancer therapy targeting angiogenesis and immune escape by the vasohibin familyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Ovarian cancer treatment targeting angiogenesis and immune tolerancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Vasohibin, a novel regulator of angiogenesis, as a useful for molecular targeted therapy and gene therapy in gynecologic malignanciesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular targeted and gene therapy using adeno-associated virus vector to suppress the peritoneal dissemination in ovarian cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

卵巣明細胞癌の抗癌剤耐性機序の解明と至適治療法の開発に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Knockout of vasohibin‐2 reduces tubulin carboxypeptidase activity and increases paclitaxel sensitivity in ovarian cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CRISPR/Cas9-mediated cervical cancer treatment targeting human papillomavirus E62019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] AAV6-mediated IL-10 expression in the lung ameliorates bleomycin-induced pulmonary fibrosis in mice2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Eradication of cervical cancer in vivo by an AAV vector that encodes shRNA targeting human papillomavirus type 16 E6/E72018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Optimization of adeno-associated virus vector-mediated gene transfer to the respiratory tract2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The hepatocyte growth factor antagonist NK4 inhibits indoleamine-2,3-dioxygenase expression via the c-Met-phosphatidylinositol 3-kinase-AKT signaling pathway2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Vasohibin-1 expression inhibits advancement of ovarian cancer producing various angiogenic factors2016

Author(s)

Saga Yasushi 嵯峨泰

嵯峨泰サガヤスシ

SAGA Yasushi 嵯峨泰