Hasegawa Takafumi 長谷川隆文

… Alternative Names

HASEGAWA Takafumi 長谷川隆文

長谷川隆文ハセガワタカフミ

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Researcher Number	70361079
Other IDs	https://orcid.org/0000-0001-5040-8985
Affiliation (Current)	2025: 独立行政法人国立病院機構仙台西多賀病院(臨床研究部), その他部局等, 臨床研究部長 2025: 独立行政法人国立病院機構仙台西多賀病院(臨床研究部), 独立行政法人国立病院機構仙台西多賀病院, 臨床研究部長
Affiliation (based on the past Project Information) *help	2017 – 2023: 東北大学, 医学系研究科, 准教授 2013 – 2016: 東北大学, 大学病院, 講師 2015: 東北大学, 大学院医学系研究科, 講師 2011 – 2013: 東北大学, 大学病院, 助教 2005: 東北大学, 大学院医学系研究科, 助手 2004: 東北大学, 大学院・医学系研究科, 助手
Review Section/Research Field	Principal Investigator Neurology / Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 52020:Neurology-related / Biological Sciences Except Principal Investigator Neurology
Keywords	Principal Investigator αシヌクレイン / エンドソーム / パーキンソン病 / エンドサイトーシス / 小胞輸送 / プリオン仮説 / シヌクレイノパチー / DNAJC13 / メンブレントラフィック / ソーティリン … More / パ－キンソン病 / 疾患修飾療法 / 進行抑制治療 / 網羅的解析 / ドパミントランスポーター / DAT / 異常タンパク伝播 / プリオン様伝播 / flotillin-1 / 異常タンパク凝集 / アクチン / アルファシヌクレイン / 細胞間伝播 / 多系統萎縮症 / ユビキチン / Cul5 / Rab40 / αシヌクレイン受容体 / 膜タンパク / 線維 / 凝集タンパク / GCI / Lewy小体 / sortilin / レビー小体 / プリオン伝播 / 受容体 / サロゲートマーカー / PETイメージング / BLOTCHIP-質量分析法 / ハイスループット解析 / フロチリン / ドパミン神経変性 / ショウジョウバエ / フロチリン-1 / PARK21 / ドパミントランスポータ－ / 異常蛋白伝播 / コンディショナルノックアウトマウス / ESCRT / 神経変性疾患 / 神経変性 / ショウジョウバエモデル / カテプシンD / レトロマー / VPS35 / PARK17 / オリゴデンドログリア / 神経細胞 / セルトラリン / α-シヌクレイン / ダイナミン / エキソソーム / 異常凝集タンパク / カテコラミン / アグレソーム / 酸化的ストレス / 細胞モデル / 異常蛋白凝集 / ミトコンドリア / アポトーシス / プロトフィブリル / チロシナーゼ / キノン体 / ドパミン … More Except Principal Investigator 小胞輸送 / Nedd4 / ESCRT / alpha-synuclein / シヌクレイン / グリア細胞質封入体 / レビー小体 / 分子イメージング / シヌクレイノパチー Less

エンドソームダイナミクスから迫るパ－キンソン病の分子病態と新規治療標的Principal Investigator
- Principal Investigator
  
  長谷川隆文
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Tohoku University
Development of novel synucleinopathy treatment targeting the receptor for alpha-synuclein fibrilsPrincipal Investigator
- Principal Investigator
  
  Hasegawa Takafumi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Tohoku University
Zeroing in on membrane trafficking: its implication for molecular pathogenesis and curative therapy of Parkinson's diseasePrincipal Investigator
- Principal Investigator
  
  Hasegawa Takafumi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
Establishment of novel disease-modifying therapy for synucleinopathy targeting internalization of protein aggregatesPrincipal Investigator
- Principal Investigator
  
  長谷川隆文
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Zeroing in on aberrant membrane trafficking in molecular pathogenesis of Parkinson's diseasePrincipal Investigator
- Principal Investigator
  
  Hasegawa Takafumi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
内在化αシヌクレインにおけるESCRTを中心とした小胞輸送に関する研究
- Principal Investigator
  
  菅野直人
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
Early diagnosis and treatment of Parkinson disease dementia
- Principal Investigator
  
  TAKEDA ATSUSHI
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Department of Clinical Research, National Hospital Organization Sendai Nishitaga National Hospital
  Tohoku University
Analysis of molecular mechanisms behind the prion hypothesis in synucleinopathyPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Takafumi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
酸化的ストレッサー存在下におけるαシヌクレイン凝集体形成と神経細胞死の関連Principal Investigator
- Principal Investigator
  
  長谷川隆文
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University

[Book] いま新薬で加速する神経変性疾患研究. タンパク質構造と病態3. 異常タンパク伝播を司るメンブレントラフィック機構2023
- Author(s)
  長谷川隆文（小野賢二郎　編集）
- Total Pages
  225
- Publisher
  羊土社
- ISBN
  9784758104128
- Data Source
  KAKENHI-PROJECT-20K07896
[Book] 脳神経内科　特集I/認知症の病態・診断・治療7. Lewy小体病における蛋白伝播メカニズム2022
- Author(s)
  長谷川隆文
- Total Pages
  6
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-20K07896
[Book] 神経治療学　パ－キンソン病疾患修飾療法開発の現況2022
- Author(s)
  長谷川隆文
- Total Pages
  6
- Publisher
  公和図書株式会社
- Data Source
  KAKENHI-PROJECT-20K07896
[Book] Annual Review神経20222022
- Author(s)
  長谷川隆文
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-20K07896
[Book] Annual Review神経2022 1)シヌクレイノパチーにおけるプリオン様伝播の分子メカニズム2022
- Author(s)
  長谷川隆文
- Total Pages
  12
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-20K07896
[Book] 非定型パーキンソニズム－基礎と臨床　III. 病態解明と治療法の確立に向けて　αシヌクレイン2019
- Author(s)
  長谷川隆文（下畑享良編）
- Total Pages
  242
- Publisher
  文光堂
- ISBN
  9784830615474
- Data Source
  KAKENHI-PROJECT-17K09744
[Book] Annual Review神経2016 II.本年の動向 7)シヌクレイノパチーの新たな病態仮説・治療ターゲット-異常タンパク伝播2016
- Author(s)
  長谷川隆文
- Total Pages
  275
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-26461263
[Journal Article] 異常タンパク伝播機構：プリオンとαシヌクレインの共通点と相違点2024
- Author(s)
  長谷川隆文
- Journal Title
  
  Dementia Japan
  
  Volume: 38
- Data Source
  KAKENHI-PROJECT-20K07896
[Journal Article] 学術集会特集号-1: 線維化αシヌクレインの細胞内取り込みに寄与する受容体探索2024
- Author(s)
  長谷川隆文
- Journal Title
  
  神経治療学
  
  Volume: 41
- Data Source
  KAKENHI-PROJECT-20K07896
[Journal Article] 特集 II/未病における脳神経内科の意義4. 神経変性疾患と未病2024
- Author(s)
  長谷川隆文
- Journal Title
  
  脳神経内科
  
  Volume: 100 Pages: 84-89
- Data Source
  KAKENHI-PROJECT-20K07896
[Journal Article] Alpha‐synuclein promotes PRMT5‐mediated H4R3me2s histone methylation by interacting with the BAF complex2023
- Author(s)
  Nakamura Takaaki、Sugeno Naoto、Hasegawa Takafumi、Ikeda Kensho、Yoshida Shun、Ishiyama Shun、Sato Kazuki、Takeda Atsushi、Aoki Masashi
- Journal Title
  
  The FEBS Journal
  
  Volume: 291 Issue: 9 Pages: 1892-1908
- DOI
  10.1111/febs.17037
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07862, KAKENHI-PROJECT-23K06823, KAKENHI-PROJECT-20K07896
[Journal Article] 認知症―Alzheimer病治療の新しい時代を迎えて:パ－キンソン病疾患修飾治療開発の動向2023
- Author(s)
  佐藤一輝、長谷川隆文
- Journal Title
  
  CLINICAL NEUROSCIENCE
  
  Volume: 41 Pages: 1209-1213
- Data Source
  KAKENHI-PROJECT-20K07896
[Journal Article] Detection of Modified Histones from Oral Mucosa of a Patient with DYT-KMT2B Dystonia2023
- Author(s)
  Sugeno Naoto、Hasegawa Takafumi、Haginoya Kazuhiro、Kubota Takafumi、Ikeda Kensuke、Nakamura Takaaki、Ishiyama Shun、Sato Kazuki、Yoshida Shun、Koshimizu Eriko、Uematsu Mitsugu、Miyatake Satoko、Matsumoto Naomichi、Aoki Masashi
- Journal Title
  
  Molecular Syndromology
  
  Volume: 14 Issue: 6 Pages: 461-468
- DOI
  10.1159/000530625
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07862, KAKENHI-PROJECT-23K06823, KAKENHI-PROJECT-20K07896, KAKENHI-PROJECT-23K27520
[Journal Article] A Case of Corticobasal Syndrome and Posterior Cortical Atrophy with Biomarkers of Alzheimer Disease2023
- Author(s)
  Sugiura Y, Baba T, Ezura M, Kikuchi A, Hasegawa T, Nagano I, Suzuki K, Takeda A
- Journal Title
  
  Alzheimer Dis Assoc Disord
  
  Volume: 37 Issue: 3 Pages: 243-245
- DOI
  10.1097/wad.0000000000000560
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07879, KAKENHI-PROJECT-23K06823, KAKENHI-PROJECT-23K06947, KAKENHI-PROJECT-20K07896
[Journal Article] Dramatic Responses to Low-Dose Pramipexole in Painful Legs and Moving Toes Syndrome2023
- Author(s)
  Umezawa Gakusuke、Hasegawa Takafumi、Ikeda Kensuke、Saito Genichi、Aoki Masashi
- Journal Title
  
  Cureus
  
  Volume: 15
- DOI
  10.7759/cureus.34763
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07896
[Journal Article] 特集頭蓋内の「流れ」と認知機能神経変性関連タンパクの細胞間伝播2023
- Author(s)
  石山隼、長谷川隆文
- Journal Title
  
  老年精神医学雑誌
  
  Volume: 34 Pages: 416-423
- Data Source
  KAKENHI-PROJECT-20K07896
[Journal Article] Clinical course of pathologically confirmed corticobasal degeneration and corticobasal syndrome2023
- Author(s)
  Aiba I, Hayashi Y, et al.
- Journal Title
  
  Brain Communications
  
  Volume: 5 Issue: 6 Pages: 1-19
- DOI
  10.1093/braincomms/fcad296
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K10319, KAKENHI-PROJECT-22K07397, KAKENHI-PROJECT-22K07538, KAKENHI-PROJECT-23K06823, KAKENHI-PROJECT-20K07896
[Journal Article] Sortilin acts as an endocytic receptor for α‐synuclein fibril2023
- Author(s)
  Ishiyama Shun、Hasegawa Takafumi、Sugeno Naoto、Kobayashi Junpei、Yoshida Shun、Miki Yasuo、Wakabayashi Koichi、Fukuda Mitsunori、Kawata Yasushi、Nakamura Takaaki、Sato Kazuki、Ezura Michinori、Kikuchi Akio、Takeda Atsushi、Aoki Masashi
- Journal Title
  
  The FASEB Journal
  
  Volume: 37 Issue: 7
- DOI
  10.1096/fj.202201605rr
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07862, KAKENHI-PROJECT-20K07879, KAKENHI-PROJECT-23K06823, KAKENHI-PROJECT-23K06947, KAKENHI-PROJECT-20K07896, KAKENHI-PROJECT-21K07452, KAKENHI-PROJECT-23K24209
[Journal Article] それでもシヌクレイン抗体療法でPDは治療できる Yesの立場から2023
- Author(s)
  長谷川隆文
- Journal Title
  
  MDSJ Letters
  
  Volume: 16 Pages: 1-3
- Data Source
  KAKENHI-PROJECT-20K07896
[Journal Article] Unraveling the Complex Interplay between Alpha-Synuclein and Epigenetic Modification2023
- Author(s)
  Sugeno Naoto、Hasegawa Takafumi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Pages: 6645-6645
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07896
[Journal Article] Distal Chronic Inflammatory Demyelinating Polyneuropathy Following COVID-19 Vaccination in a Patient with Solitary Plasmacytoma: A Case Report and Literature Review2023
- Author(s)
  Kubota T, Shijo T, Ikeda K, Mitobe Y, Umezawa S, Misu T, Hasegawa T, Aoki M.
- Journal Title
  
  Intern. Med.
  
  Volume: 62 Issue: 16 Pages: 2419-2425
- DOI
  10.2169/internalmedicine.1365-22
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2023-08-15
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07896
[Journal Article] Unraveling the Complex Interplay between Alpha-Synuclein and Epigenetic Modification2023
- Author(s)
  Sugeno Naoto、Hasegawa Takafumi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 7 Pages: 6645-6645
- DOI
  10.3390/ijms24076645
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07862, KAKENHI-PROJECT-23K06823
[Journal Article] Olfactory Dysfunction, an Often Neglected Symptom of Hydrocephalus: Experience from a Case of Late-Onset Idiopathic Aqueductal Stenosis2023
- Author(s)
  Yamazaki Naoya、Hasegawa Takafumi、Ikeda Kensuke、Miyata Ako、Osawa Shin-ichiro、Niizuma Kuniyasu、Kanno Shigenori、Tominaga Teiji、Aoki Masashi
- Journal Title
  
  Case Reports in Neurology
  
  Volume: 15 Issue: 1 Pages: 41-47
- DOI
  10.1159/000529532
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07896, KAKENHI-PROJECT-20K11202, KAKENHI-PROJECT-23K21847
[Journal Article] 特集「--“pathy”でせまる中枢神経疾患」α-synucleinopathy: 凝集α-synによる細胞毒性2022
- Author(s)
  江面道典、長谷川隆文
- Journal Title
  
  画像診断
  
  Volume: - Pages: 42-42
- Data Source
  KAKENHI-PROJECT-20K07896
[Journal Article] Plasma sphingolipid abnormalities in neurodegenerative diseases2022
- Author(s)
  Oizumi Hideki、Sugimura Yoko、Totsune Tomoko、Kawasaki Iori、Ohshiro Saki、Baba Toru、Kimpara Teiko、Sakuma Hiroaki、Hasegawa Takafumi、Kawahata Ichiro、Fukunaga Kohji、Takeda Atsushi
- Journal Title
  
  PLOS ONE
  
  Volume: 17 Issue: 12 Pages: 279315-279336
- DOI
  10.1371/journal.pone.0279315
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07896, KAKENHI-PROJECT-22K06644, KAKENHI-PROJECT-21K17525
[Journal Article] Deciphering the prion-like behavior of pathogenic protein aggregates in neurodegenerative diseases.2022
- Author(s)
  Yoshida S, Hasegawa T.
- Journal Title
  
  Neurochem Int
  
  Volume: 155 Pages: 105307-105307
- DOI
  10.1016/j.neuint.2022.105307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07896, KAKENHI-PROJECT-19K16998
[Journal Article] V. Endosome, Lysosome, Exosome: 小胞とは？C. Exosomeの機能-4. プリオン仮説とエクソソーム2022
- Author(s)
  4.石山駿、長谷川隆文
- Journal Title
  
  CLINICAL NEUROSCIENCE
  
  Volume: 40 Pages: 859-863
- Data Source
  KAKENHI-PROJECT-20K07896
[Journal Article] 動的へテラルキー-脳は階層固定的か? へテラルキーからみた神経疾患: オートファジー2022
- Author(s)
  吉田隼、長谷川隆文
- Journal Title
  
  CLINICAL NEUROSCIENCE
  
  Volume: 39 Pages: 859-863
- Data Source
  KAKENHI-PROJECT-20K07896
[Journal Article] 特集I/Parkinson病および類縁疾患の病態. 5. タンパク伝播メカニズムからみたLewy小体病の多様性.2022
- Author(s)
  2.菅野直人、長谷川隆文
- Journal Title
  
  脳神経内科
  
  Volume: -
- Data Source
  KAKENHI-PROJECT-20K07896
[Journal Article] Phosphorylated alpha‐synuclein in Iba1‐positive macrophages in the skin of patients with Parkinson's disease2022
- Author(s)
  Oizumi Hideki、Yamasaki Kenshi、Suzuki Hiroyoshi、Ohshiro Saki、Saito Yuko、Murayama Shigeo、Sugimura Yoko、Hasegawa Takafumi、Fukunaga Kohji、Takeda Atsushi
- Journal Title
  
  Annals of Clinical and Translational Neurology
  
  Volume: 9 Issue: 8 Pages: 1136-1146
- DOI
  10.1002/acn3.51610
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07896, KAKENHI-PROJECT-22K07538, KAKENHI-PROJECT-22H04923
[Journal Article] Mirror writing and cortical hypometabolism in Parkinson’s disease2022
- Author(s)
  Shinohara M, Yokoi K, Hirayama K, Kanno S, Hosokai Y, Nishio Y, Ishioka T, Otsuki M, Takeda A, Baba T, Aoki M, Hasegawa T, Kikuchi A, Narita W, Mori E, Suzuki K
- Journal Title
  
  PLoS One
  
  Volume: 17 Issue: 12 Pages: 0279007-0279007
- DOI
  10.1371/journal.pone.0279007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07879, KAKENHI-PROJECT-20K07896, KAKENHI-PROJECT-20K11202, KAKENHI-PROJECT-20K19416, KAKENHI-PROJECT-23K21847, KAKENHI-PROJECT-20H00001
[Journal Article] 内科疾患の診断基準・病型分類・重症度. 第7章神経・筋：5. Parkinson病2021
- Author(s)
  長谷川隆文
- Journal Title
  
  臨床雑誌「内科」
  
  Volume: 127 Pages: 830-835
- Data Source
  KAKENHI-PROJECT-20K07896
[Journal Article] High prevalence of serum anti-NH2-terminal of α-enolase antibodies in patients with multiple system atrophy and corticobasal syndrome2021
- Author(s)
  Kikuchi A, Yoneda M, Hasegawa T, Matsunaga A, Ikawa M, Nakamura T, Ezura M, Baba T, Sugeno N, Ishiyama S, Nakamoto Y, Takeda A, Aoki M
- Journal Title
  
  J Neurol
  
  Volume: 268 Issue: 11 Pages: 4291-4295
- DOI
  10.1007/s00415-021-10553-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09789, KAKENHI-PROJECT-20K07862, KAKENHI-PROJECT-20K07879, KAKENHI-PROJECT-20K07896
[Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)12021
- Author(s)
  Daniel J Klionsky、Shu Aizawa、Amal Kamal Abdel-Aziz、Sara Abdelfatah、Mahmoud Abdellatif、Asghar Abdoli、Steffen Abel、Hagai Abeliovich、Marie H Abildgaard、Yakubu Princely Abudu、Abraham Acevedo-Arozena、Iannis E Adamopoulos、Khosrow Adeli、Timon E Adolph、Annagrazia Adornetto、Elma Aflaki、Galila Agam et al.
- Journal Title
  
  Autophagy
  
  Volume: 17 Issue: 1 Pages: 1-382
- DOI
  10.1080/15548627.2020.1797280
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06375, KAKENHI-PROJECT-19K07568, KAKENHI-PROJECT-20K06501, KAKENHI-PROJECT-20K06636, KAKENHI-PROJECT-20K07896, KAKENHI-PROJECT-20K21769, KAKENHI-PLANNED-20H05772, KAKENHI-PROJECT-19H01042, KAKENHI-PROJECT-18H02439, KAKENHI-PROJECT-18H02656, KAKENHI-PROJECT-18H02807, KAKENHI-PROJECT-20J00363, KAKENHI-PROJECT-18K06210, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-18K08079, KAKENHI-PROJECT-18K09427, KAKENHI-PROJECT-19K08851, KAKENHI-PROJECT-18KK0193, KAKENHI-PLANNED-19H05710, KAKENHI-PROJECT-18H02901, KAKENHI-PROJECT-20H02990, KAKENHI-PUBLICLY-20H05504, KAKENHI-PROJECT-19H03471, KAKENHI-PROJECT-19H03791, KAKENHI-PROJECT-20H03249, KAKENHI-PROJECT-19K09677, KAKENHI-PROJECT-20K07910, KAKENHI-PROJECT-20K08460, KAKENHI-PROJECT-20K08662, KAKENHI-PROJECT-21K07926, KAKENHI-PROJECT-20K21531, KAKENHI-PROJECT-19K24690, KAKENHI-PROJECT-23K21397
[Journal Article] Fatty Acid-Binding Protein 3 Expression in the Brain and Skin in Human Synucleinopathies.2021
- Author(s)
  Oizumi H, Yamasaki K, Suzuki H, Hasegawa T, Sugimura Y, Baba T, Fukunaga K, Takeda A
- Journal Title
  
  Front Aging Neurosci
  
  Volume: 13 Pages: 648982-648982
- DOI
  10.3389/fnagi.2021.648982
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07896
[Journal Article] Regulation of the tubulin polymerization-promoting protein by Ca2+/S100 proteins2021
- Author(s)
  Doi Seita、Fujioka Naoki、Ohtsuka Satomi、Kondo Rina、Yamamoto Maho、Denda Miwako、Magari Masaki、Kanayama Naoki、Hatano Naoya、Morishita Ryo、Hasegawa Takafumi、Tokumitsu Hiroshi
- Journal Title
  
  Cell Calcium
  
  Volume: 96 Pages: 102404-102404
- DOI
  10.1016/j.ceca.2021.102404
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K05231, KAKENHI-PROJECT-18K02255, KAKENHI-PROJECT-20K07896
[Journal Article] αシヌクレイン伝播阻止を目指したパーキンソン病の創薬研究2020
- Author(s)
  長谷川隆文
- Journal Title
  
  BIO Clinica
  
  Volume: 35 Pages: 26-30
- Data Source
  KAKENHI-PROJECT-20K07896
[Journal Article] αシヌクレイン2020
- Author(s)
  長谷川隆文
- Journal Title
  
  脳科学辞典
  
  Volume: -
- DOI
  10.14931/bsd.9486
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07896
[Journal Article] Possible modulation of the amplitude and frequency of resting parkinsonian tremor by touching the trapezius muscle2020
- Author(s)
  Hasegawa T, Ishiyama S, Nakamura T
- Journal Title
  
  Clin Case Rep
  
  Volume: 8 Issue: 8 Pages: 1594-1594
- DOI
  10.1002/ccr3.2893
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07896
[Journal Article] Logopenic aphasia due to Lewy body disease dramatically improved with donepezil2020
- Author(s)
  Kakinuma K, Baba T, Ezura M, Endo K, Saito Y, Narita W, Iizuka O, Yoshiyuki Nishio Y, Kikuchi A, Hasegawa T, Aoki M, Suzuki K
- Journal Title
  
  eNeurologicalSc
  
  Volume: 19 Pages: 100241-100241
- DOI
  10.1016/j.ensci.2020.100241
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09789, KAKENHI-PROJECT-20K07879, KAKENHI-PROJECT-20K07896, KAKENHI-PUBLICLY-19H04890
[Journal Article] 「シヌクレイノパチーの新たな展開」－αシヌクレインを標的としたパーキンソン病の疾患修飾薬開発戦略2020
- Author(s)
  長谷川隆文
- Journal Title
  
  BRAIN and NERVE
  
  Volume: 72 Pages: 143-150
- Data Source
  KAKENHI-PROJECT-17K09744
[Journal Article] An unusual cause of difficulty in walking downstairs: Focal task‐specific dystonia in the lower limb2020
- Author(s)
  Hasegawa T
- Journal Title
  
  Clin Case Rep
  
  Volume: 8 Issue: 8 Pages: 1595-1595
- DOI
  10.1002/ccr3.2894
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07896
[Journal Article] 免疫抗体療法の現状と未来-パーキンソン病の疾患修飾療法に向かって2020
- Author(s)
  長谷川隆文
- Journal Title
  
  MDSJ Letters
  
  Volume: 13 Pages: 1-3
- NAID
  40022460722
- Data Source
  KAKENHI-PROJECT-20K07896
[Journal Article] Clinical and metabolic changes in Parkinson's disease with atrophy in the nucleus basalis of Meynert2020
- Author(s)
  Gang M, Baba T, Hosokai Y, Nishio Y, Kikuchi A, Hirayama K, Hasegawa T, Aoki M, Takeda A, Mori E, Suzuki K
- Journal Title
  
  Mov Disord
  
  Volume: in press Issue: 5 Pages: 825-832
- DOI
  10.1002/mds.27988
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09789, KAKENHI-PLANNED-15H05915, KAKENHI-PUBLICLY-18H05058, KAKENHI-PROJECT-17K09744, KAKENHI-PUBLICLY-19H04890
[Journal Article] αシヌクレイン凝集・伝播を標的としたParkinson病疾患修飾療法開発の現況2020
- Author(s)
  長谷川隆文
- Journal Title
  
  神経治療学
  
  Volume: 37 Pages: 1-4
- NAID
  130008044068
- Data Source
  KAKENHI-PROJECT-20K07896
[Journal Article] 鼎談　治療標的としてのαシヌクレイン2020
- Author(s)
  長谷川隆文、下畑享良、桑原聡
- Journal Title
  
  BRAIN and NERVE
  
  Volume: 72 Pages: 97-105
- Data Source
  KAKENHI-PROJECT-17K09744
[Journal Article] Mutation analysis of LRP10 in Japanese patients with familial Parkinson’s disease, progressive supranuclear palsy, and fronto-temporal dementia2019
- Author(s)
  Daida K, Nishioka K, Li Y, Yoshino H, Kikuchi A, Hasegawa T, Funayama M, Hattori N
- Journal Title
  
  Neurobiol Aging
  
  Volume: 84 Pages: 235.e11-235.e16
- DOI
  10.1016/j.neurobiolaging.2019.08.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09789, KAKENHI-PROJECT-19K08003, KAKENHI-PROJECT-17K09744
[Journal Article] Glymphatic systemー脳のゴミとその処理2019
- Author(s)
  長谷川隆文
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 37 Pages: 87-89
- Data Source
  KAKENHI-PROJECT-17K09744
[Journal Article] Longitudinal changes in 18F-THK5351 PET in corticobasal syndrome2019
- Author(s)
  Ezura M, Kikuchi A, Ishiki A, Okamura N, Hasegawa T, Harada R, Watanuki S, Funaki Y, Hiraoka K, Baba T, Sugeno N, Oshima R, Yoshida S, Kobayashi J, Kobayashi M, Tano O, Nakashima I, Mugikura S, Iwata R, Taki Y, Furukawa K, Arai H, Furumoto S, Tashiro M, Yanai K, Kudo Y, Takeda A, Aoki M
- Journal Title
  
  Eur J Neurol
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05683
[Journal Article] パーキンソン病診療最前線：パーキンソン病の成因研究2019
- Author(s)
  長谷川隆文
- Journal Title
  
  Pharma Medica
  
  Volume: 37 Pages: 9-13
- Data Source
  KAKENHI-PROJECT-17K09744
[Journal Article] Longitudinal changes in 18F-THK5351 PET in corticobasal syndrome2019
- Author(s)
  Ezura M, Kikuchi A, Ishiki A, Okamura N, Hasegawa T, Harada R, Watanuki S, Funaki Y, Hiraoka K, Baba T, Sugeno N, Oshima R, Yoshida S, Kobayashi J, Kobayashi M, Tano O, Nakashima I, Mugikura S, Iwata R, Taki Y, Furukawa K, Arai H, Furumoto S, Tashiro M, Yanai K, Kudo Y, Takeda A, Aoki M
- Journal Title
  
  Eur J Neurol
  
  Volume: 26 Issue: 9 Pages: 1205-1211
- DOI
  10.1111/ene.13966
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09789, KAKENHI-PROJECT-17K20083, KAKENHI-PROJECT-19KK0212, KAKENHI-PROJECT-16H05385, KAKENHI-PROJECT-17K09318, KAKENHI-PROJECT-17K09744, KAKENHI-PROJECT-17K09745, KAKENHI-PROJECT-18K15538, KAKENHI-PROJECT-18H02771
[Journal Article] Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis.2019
- Author(s)
  Carballo-Carbajal I, Laguna A, Romero-Gimenez J, Cuadros T, Bove J, Martinez-Vicente M, Parent A, Gonzalez-Sepulveda M, Penuelas N, Torra A, Rodrguez-Galvan B, Ballabio A, Hasegawa T, Bortolozzi A, Gelpi E and Vila M.
- Journal Title
  
  Nat Commun
  
  Volume: 10 Issue: 1 Pages: 973-973
- DOI
  10.1038/s41467-019-08858-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05683, KAKENHI-PROJECT-17K09744
[Journal Article] Unveiling the coupling of flotillin-1 and extracellular α-synuclein: relevance to dopamine transporter trafficking and Lewy body formation2019
- Author(s)
  Kobayashi J, Hasegawa T, Sugeno N, Yoshida S, Miki Y, Fukuda M, Kawahata I, Yamakuni T, Tomiyama A, Kawata Y, Ezura M, Kikuchi A, Baba T, Wakabayashi K, Takeda A, Aoki M
- Journal Title
  
  FASEB Journal
  
  Volume: 33 Issue: 9 Pages: 10240-10256
- DOI
  10.1096/fj.201802051r
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09789, KAKENHI-PROJECT-17H02076, KAKENHI-PROJECT-18H02533, KAKENHI-PROJECT-17K09744, KAKENHI-PROJECT-17K09745, KAKENHI-PROJECT-18K19722, KAKENHI-PROJECT-19K07097
[Journal Article] Cutting Edge－メンブレントラフィックに着目したパーキンソン病の病態解明2018
- Author(s)
  長谷川隆文
- Journal Title
  
  Medical Science Digest
  
  Volume: 44 Pages: 5-7
- Data Source
  KAKENHI-PROJECT-17K09744
[Journal Article] Zeroing in on membrane trafficking in pathogenesis of PD.2018
- Author(s)
  長谷川隆文
- Journal Title
  
  Medical Science Digest
  
  Volume: 7 Pages: 115-117
- Data Source
  KAKENHI-PROJECT-17K09744
[Journal Article] αシヌクレイン細胞間伝播を標的としたシヌクレイノパチー疾患修飾療法の開発2018
- Author(s)
  長谷川隆文
- Journal Title
  
  Brain and Nerve
  
  Volume: 70 Pages: 551-556
- NAID
  40021572953
- Data Source
  KAKENHI-PROJECT-17K09744
[Journal Article] Zeroing in on membrane trafficking in pathogenesis of PD2018
- Author(s)
  長谷川隆文
- Journal Title
  
  Bio Clinica
  
  Volume: 7 Pages: 115-117
- Data Source
  KAKENHI-PUBLICLY-17H05683
[Journal Article] αシヌクレイン細胞間伝播を標的としたシヌクレイノパチー疾患修飾療法の開発2018
- Author(s)
  長谷川隆文
- Journal Title
  
  Brain and Nerve
  
  Volume: 70 Pages: 551-556
- NAID
  40021572953
- Data Source
  KAKENHI-PUBLICLY-17H05683
[Journal Article] DnaJ/Hsp40 family and Parkinson’s disease.2018
- Author(s)
  Hasegawa T, Yoshida S, Sugeno N, Kobayashi J, Aoki M.
- Journal Title
  
  Front Neurosci
  
  Volume: 11 Pages: 743-743
- DOI
  10.3389/fnins.2017.00743
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09744, KAKENHI-PROJECT-17K09745, KAKENHI-PUBLICLY-17H05683
[Journal Article] PEG-J tube breakage in a patient with Parkinson's disease receiving levodopa-carbidopa intestinal gel therapy.2018
- Author(s)
  Soga T, Sugeno N, Baba T, Jin X, Koike T, Hasegawa T, Aoki M.
- Journal Title
  
  Neurol Clin Neurosci
  
  Volume: 6 Issue: 6 Pages: 197-198
- DOI
  10.1111/ncn3.12220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09744, KAKENHI-PUBLICLY-17H05683
[Journal Article] Cutting Edge－メンブレントラフィックに着目したパーキンソン病の病態解明2018
- Author(s)
  長谷川隆文
- Journal Title
  
  Medical Science Digest
  
  Volume: 44 Pages: 5-7
- Data Source
  KAKENHI-PUBLICLY-17H05683
[Journal Article] Parkinson’s disease-linked DNAJC13 mutation aggravates α-synuclein-induced neurotoxicity through perturbation of endosomal trafficking.2018
- Author(s)
  Yoshida S, Hasegawa T, Suzuki M, Sugeno N, Kobayashi J, Ueyama M, Fukuda M, Ido-Fujibayashi A, Sekiguchi K, Ezura M, Kikuchi A, Baba T, Takeda A, Mochizuki H, Nagai Y and Aoki M.
- Journal Title
  
  Hum Mol Genet.
  
  Volume: 27 Issue: 5 Pages: 823-836
- DOI
  10.1093/hmg/ddy003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09744, KAKENHI-PROJECT-17K09745, KAKENHI-PROJECT-17K19658, KAKENHI-PROJECT-17K16134, KAKENHI-PROJECT-16H05325, KAKENHI-PUBLICLY-17H05682, KAKENHI-PUBLICLY-17H05683, KAKENHI-PROJECT-26461303, KAKENHI-PROJECT-15K19502, KAKENHI-PROJECT-17K09789, KAKENHI-PROJECT-15K09331
[Journal Article] Longitudinal study of cognitive and cerebral metabolic changes in Parkinson's disease.2017
- Author(s)
  Baba T, Hosokai Y, Nishio Y, Kikuchi A, Hirayama K, Suzuki K, Hasegawa T, Aoki M, Takeda A, Mori E.
- Journal Title
  
  J Neurol Sci
  
  Volume: 372 Pages: 288-293
- DOI
  10.1016/j.jns.2016.11.068
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-15H01550, KAKENHI-PROJECT-26461263, KAKENHI-PROJECT-26461303, KAKENHI-PROJECT-17K09789
[Journal Article] Membrane Trafficking Illuminates a Path to Parkinson’s Disease2017
- Author(s)
  Hasegawa T, Sugeno N, Kikuchi A, Baba T, Aoki M.
- Journal Title
  
  Tohoku J. Exp. Med.
  
  Volume: 242 Issue: 1 Pages: 63-76
- DOI
  10.1620/tjem.242.63
- NAID
  130005679072
- ISSN
  0040-8727, 1349-3329
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09744, KAKENHI-PROJECT-17K09745, KAKENHI-PROJECT-17K09789, KAKENHI-PUBLICLY-17H05683, KAKENHI-PROJECT-26461303
[Journal Article] Aβ accumulation causes MVB enlargement and is modelled by dominant negative VPS4A.2017
- Author(s)
  Willen K, Edgar JR, Hasegawa T, Tanaka N, Futter CE, Gouras GK.
- Journal Title
  
  Mol Neurodeg
  
  Volume: 12 Issue: 1 Pages: 61-61
- DOI
  10.1186/s13024-017-0203-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09744, KAKENHI-PUBLICLY-17H05683
[Journal Article] On the utility of MIBG SPECT/CT in evaluating cardiac sympathetic dysfunction in Lewy body diseases2016
- Author(s)
  Odagiri H, Baba T, Nishio Y, Iizuka O, Matsuda M, Inoue K, Kikuchi A, Hasegawa T, Aoki M, Takeda A, Taki Y, Mori E
- Journal Title
  
  PLoS One
  
  Volume: 11(4) Issue: 4 Pages: 0152746-0152746
- DOI
  10.1371/journal.pone.0152746
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461263, KAKENHI-PROJECT-24390219, KAKENHI-PROJECT-24390278, KAKENHI-PUBLICLY-15H01550, KAKENHI-PROJECT-26461303
[Journal Article] パーキンソン病と細胞内輸送2016
- Author(s)
  長谷川隆文
- Journal Title
  
  脳21
  
  Volume: Vol.19 No.4 Pages: 27-31
- Data Source
  KAKENHI-PROJECT-26461263
[Journal Article] In vivo visualization of tau pathology using 18F-THK5351 PET in corticobasal syndrome.2016
- Author(s)
  Kikuchi A, Okamura N, Hasegawa T, Harada R, Watanuki S, Funaki Y, Kobayashi M, Tano O, Baba T, Sugeno N, Oshima R, Yoshida S, Kobayashi J, Ezura M, Hiraoka K, Mugikura S, Takase K, Iwata R, Taki Y, Furukawa K, HArai H, Furumoto S, Tashiro M, Yanai K, Kudo Y, Takeda A，Aoki M.
- Journal Title
  
  Neurology
  
  Volume: 87 Issue: 22 Pages: 2309-2316
- DOI
  10.1212/wnl.0000000000003375
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-15H01550, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-26461263, KAKENHI-PROJECT-15K19767, KAKENHI-PROJECT-26461303, KAKENHI-PROJECT-16K15570
[Journal Article] ESCRT-0 dysfunction compromises autophagic degradation of protein aggregates and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways2016
- Author(s)
  Oshima R, Hasegawa T, Tamai K, Sugeno N, Yoshida S, Kobayashi J, Kikuchi A, Baba T, Futatsugi A, Sato I, Satoh K, Takeda A, Aoki M and Tanaka N
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 24997-24997
- DOI
  10.1038/srep24997
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461263, KAKENHI-PUBLICLY-15H01550, KAKENHI-PROJECT-24300326, KAKENHI-PROJECT-24390219, KAKENHI-PROJECT-15K14414, KAKENHI-PROJECT-26461303
[Journal Article] 検査からみる神経疾患－神経疾患とエクソソーム2016
- Author(s)
  長谷川隆文
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 34 Pages: 1388-1390
- Data Source
  KAKENHI-PROJECT-26461263
[Journal Article] αシヌクレイン細胞間伝播を制御する小胞輸送機構2016
- Author(s)
  長谷川隆文
- Journal Title
  
  最新醫學
  
  Volume: 71 Pages: 46-50
- Data Source
  KAKENHI-PROJECT-26461263
[Journal Article] A Japanese multicenter survey characterizing pain in Parkinson's disease2016
- Author(s)
  Kubo SI, Hamada S, Maeda T, Uchiyama T, Hashimoto M, Nomoto N, Kano O, Takahashi T, Terashi H, Takahashi T, Hatano T, Hasegawa T, Baba Y, Sengoku Rl, Watanabe H, Kadowaki T, Inoue M, Kaneko S, Shimura H, Nagayama H
- Journal Title
  
  Journal of The Neurological Science
  
  Volume: 365 Pages: 162-166
- DOI
  10.1016/j.jns.2016.04.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461263, KAKENHI-PUBLICLY-15H01550, KAKENHI-PROJECT-16K09675, KAKENHI-PROJECT-16K09736
[Journal Article] パーキンソン病診療up date 1. プリオン仮説2015
- Author(s)
  長谷川隆文
- Journal Title
  
  Pharma Medica
  
  Volume: 33 Pages: 9-13
- Data Source
  KAKENHI-PROJECT-26461263
[Journal Article] 特集：パーキンソン病の治療-パーキンソン病の発症機序2015
- Author(s)
  菅野直人、長谷川隆文
- Journal Title
  
  Current Therapy
  
  Volume: 33 Pages: 14-19
- Data Source
  KAKENHI-PROJECT-26461263
[Journal Article] K63-linked ubiquitination by E3 Ubiquitin Ligase Nedd4-1 facilitates endosomal sequestration of internalized alpha-synuclein.2014
- Author(s)
  Sugeno N, Hasegawa T, Tanaka N, Fukuda M, Wakabayashi K, Oshima R, Konno M, Miura E, Kikuchi A, Baba T, Anan T, Nakao M, Geisler S, Aoki M, Takeda A.
- Journal Title
  
  J Biol Chem
  
  Volume: 289 Issue: 26 Pages: 18137-18151
- DOI
  10.1074/jbc.m113.529461
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591266, KAKENHI-PROJECT-24300326, KAKENHI-PROJECT-24390219, KAKENHI-PROJECT-26461263, KAKENHI-PROJECT-26461303
[Journal Article] VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease.2014
- Author(s)
  Miura E, Hasegawa T, Konno M, Suzuki M, Sugeno N, Fujikake N, Geisler S, Tabuchi M, Oshima R, Kikuchi A, Baba T, Wada K, Nagai Y, Takeda A, Aoki M.
- Journal Title
  
  Neurobio Dis
  
  Volume: 71 Pages: 1-13
- DOI
  10.1016/j.nbd.2014.07.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591266, KAKENHI-PROJECT-24390219, KAKENHI-PROJECT-24591286, KAKENHI-PUBLICLY-25110741, KAKENHI-PROJECT-26461263, KAKENHI-PROJECT-26461303, KAKENHI-PROJECT-26670446
[Journal Article] Improvement of freezing of gait in patients with Parkinson’s disease by imagining bicycling.2014
- Author(s)
  Kikuchi A, Baba T, Hasegawa T, Sugeno N, Konno M, Miura E, Oshima R, Aoki M, Takeda A.
- Journal Title
  
  Case Rep Neurol
  
  Volume: 6 Issue: 1 Pages: 92-95
- DOI
  10.1159/000362119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591266, KAKENHI-PROJECT-25461264, KAKENHI-PROJECT-26461303
[Journal Article] Isolated posterior column lesion in a case with mixed connective tissue disease2014
- Author(s)
  Tomomi Shijo, Naoto Sugeno, Hiroshi Kuroda, Takafumi Hasegawa, Atsushi Takeda and Masashi Aoki
- Journal Title
  
  Neurology and Clinical Neuroscience
  
  Volume: in press Issue: 3 Pages: 95-95
- DOI
  10.1111/ncn3.88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461264
[Journal Article] 1.Neural Substrates of Cognitive Subtypes in Parkinson's Disease: A 3-Year Longitudinal Study2014
- Author(s)
  Shoji Y¸ Nishio Y, Baba T, Uchiyama M, Yokoi K, Ishioka T, Hosokai Y, Hirayama K, Fukuda H, Aoki M, Hasegawa T, Takeda A, Mori E.
- Journal Title
  
  PLoS ONE
  
  Volume: 9(10) Issue: 10 Pages: e110547-e110547
- DOI
  10.1371/journal.pone.0110547
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23700617, KAKENHI-PROJECT-24390219, KAKENHI-PROJECT-24390278, KAKENHI-PROJECT-26461263
[Journal Article] Retrospective analysis of Guillain-Barre syndrome and Fisher syndrome after the Great East Japan Earthquake2014
- Author(s)
  Hirofumi Tsuboi, Naoto Sugeno, Maki Tateyama, Ichiro Nakashima, Takafumi Hasegawa, Hiroshi Kuroda, Kimihiko Kaneko, Michiko Kobayashi, Aya Ishigaki, Juichi Fujimori and Masashi Aoki
- Journal Title
  
  Brain and Behavior
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461264
[Journal Article] Rhinorrhea in Parkinson's disease: a consecutive multicenter study in Japan.2014
- Author(s)
  Kano O, Yoshioka M, Nagayama H, Hamada S, Maeda T, Hasegawa T, Kadowaki T, Sengoku R, Terashi H, Hatano T, Nomoto N, Inoue M, Shimura H, Takahashi T, Uchiyama T, Watanabe H, Kaneko S, Takahashi T, Baba Y, Kubo S; Young Japanese Expert Group for Parkinson's Disease and Movement Disorders: YJ-EXPANDS.
- Journal Title
  
  Journal of Neurological Science
  
  Volume: 343 Issue: 1-2 Pages: 88-90
- DOI
  10.1016/j.jns.2014.05.039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790897, KAKENHI-PROJECT-25461290, KAKENHI-PROJECT-26461263
[Journal Article] K63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized alpha-synuclein2014
- Author(s)
  Sugeno N, Hasegawa T, Tanaka N, Fukuda M, Wakabayashi K, Oshima R, Konno M, Miura E, Kikuchi A, Baba T, Anan T, Nakao M, Geisler S, Aoki M, Takeda A.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461264
[Journal Article] Olfactory Dysfunction and Dementia in Parkinson's Disease.2014
- Author(s)
  Takeda A, Baba T, Kikuchi A, Hasegawa T, Sugeno N, Konno M, Miura E, Mori E.
- Journal Title
  
  J Parkinsons Dis.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461264
[Journal Article] Olfactory dysfunction and dementia in Parkinson's disease.2014
- Author(s)
  Takeda A, Baba T, Kikuchi A, Hasegawa T, Sugeno N, Konno M, Miura E, Mori E.
- Journal Title
  
  J Parkinsons Dis
  
  Volume: 4 Issue: 2 Pages: 181-187
- DOI
  10.3233/jpd-130277
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591266, KAKENHI-PROJECT-24390219, KAKENHI-PROJECT-24390278, KAKENHI-PROJECT-26461263, KAKENHI-PROJECT-26461303
[Journal Article] Pathogenesis of Multiple system atrophy.2013
- Author(s)
  Hasegawa T, Kikuchi A, Takeda A.
- Journal Title
  
  Neurol Clin Neurosci
  
  Volume: 1 (6) Issue: 6 Pages: 189-194
- DOI
  10.1111/ncn3.57
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591228, KAKENHI-PUBLICLY-24111502, KAKENHI-PROJECT-24390219, KAKENHI-PROJECT-24659423
[Journal Article] Hypometabolism in the supplementary and anterior cingulate cortices is related to dysphagia in Parkinson's disease: a cross-sectional and 3-year longitudinal cohort study2013
- Author(s)
  Akio Kikuchi, Toru Baba, Takafumi Hasegawa, Michiko Kobayashi, Naoto Sugeno, Masatoshi Konno, Emiko Miura, Yoshiyuki Hosokai, Toshiyuki Ishioka, Yoshiyuki Nishio, Kazumi Hirayama, Kyoko Suzuki, Masashi Aoki, ShokiTakahashi, Hiroshi Fukuda, Yasuto Itoyama, Etsuro Mori, Atsushi Takeda
- Journal Title
  
  BMJ Open
  
  Volume: 3 Issue: 3 Pages: e002249-e002249
- DOI
  10.1136/bmjopen-2012-002249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22611002, KAKENHI-PROJECT-23591228, KAKENHI-PROJECT-23591266, KAKENHI-PUBLICLY-24111502, KAKENHI-PROJECT-24390219, KAKENHI-PROJECT-24390278, KAKENHI-PROJECT-24659423, KAKENHI-PROJECT-25461264
[Journal Article] Anti-voltage-gated potassium channel antibody is associated with chronic autonomic and sensory neuropathy.2013
- Author(s)
  Kaneko K, Tano O, Kikuchi A, Hasegawa T, Tateyama M, Yoshioka M, Saito H, Watanabe O, Takeda A, Aoki M.
- Journal Title
  
  J Neurol
  
  Volume: 260 Issue: 1 Pages: 315-317
- DOI
  10.1007/s00415-012-6730-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591228, KAKENHI-PROJECT-23591266, KAKENHI-PROJECT-24659423, KAKENHI-PROJECT-25461286
[Journal Article] Severe olfactory dysfunction is a prodromal symptom of dementia associated with Parkinson's disease : a 3 year longitudinal study2012
- Author(s)
  Baba T, Kikuchi A, Hirayama K, Nishio Y, Hosokai Y, Kanno S, Hasegawa T, Sugeno N, Konno M, Suzuki K, Takahashi S, Fukuda H, Aoki M, Itoyama Y, Mori E, Takeda A
- Journal Title
  
  Brain
  
  Volume: 135 Pages: 161-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591228
[Journal Article] Suppression of dynamin GTPase decreases alpha-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy.2012
- Author(s)
  Konno M, Hasegawa T, Baba T, Miura E, Sugeno N, Kikuchi A, Fiesel FC, Sasaki T, Aoki M, Itoyama Y, Takeda A.
- Journal Title
  
  Mol Neurodegener
  
  Volume: 7 Issue: 1 Pages: 38-38
- DOI
  10.1186/1750-1326-7-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591228, KAKENHI-PROJECT-23591266, KAKENHI-PROJECT-23790974, KAKENHI-PROJECT-24390219, KAKENHI-PROJECT-24390222, KAKENHI-PROJECT-24659423, KAKENHI-PUBLICLY-24111502
[Journal Article] Severe olfactory dysfunction is a prodromal symptom of dementia associated with Parkinson's disease : a 3-year longitudinal study2012
- Author(s)
  BabaT, Kikuchi A, Hirayama K, Nishio Y, Hosokai Y, Kanno S, Hasegawa T, Sugeno N, Konno M, Suzuki K, et al
- Journal Title
  
  Brain
  
  Volume: 135 Issue: 1 Pages: 162-169
- DOI
  10.1093/brain/awr321
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300345, KAKENHI-PROJECT-22611002, KAKENHI-PROJECT-22791104, KAKENHI-PUBLICLY-23119703, KAKENHI-PUBLICLY-23135502, KAKENHI-PROJECT-23591228, KAKENHI-PROJECT-24390219, KAKENHI-PROJECT-24659423, KAKENHI-PUBLICLY-24111502
[Journal Article] Differentiating Parkinson's disease from multiple system atrophy by [123I] meta-iodobenzylguanidine myocardial scintigraphy and olfactory test2011
- Author(s)
  Kikuchi A, Baba T, Hasegawa T, Sugeno N, Konno M, Takeda A
- Journal Title
  
  Parkinsonism & Related Disorders
  
  Volume: 17 Issue: 9 Pages: 698-700
- DOI
  10.1016/j.parkreldis.2011.07.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591228, KAKENHI-PROJECT-23790974
[Journal Article] Pathophysiology and clinical presentation of Parkinson's disease-up to date" pathomechanisms of Parkinson's disease.2011
- Author(s)
  Hasegawa T
- Journal Title
  
  臨床神経学
  
  Volume: 51 Pages: 1165-1165
- NAID
  130004504864
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591228
[Journal Article] The AAA-A TPase VPS4 Regulates Extracellular Secretion and Lysosomal Targeting of alpha-Synuclein2011
- Author(s)
  Hasegawa T, Konno M, Baba T, Sugeno N, Kikuchi A, Kobayashi M, Miura E, Tanaka N, Tamai K, Furukawa K, Arai H, Mori F, Wakabayashi K, Aoki M, Itoyama Y, Takeda A
- Journal Title
  
  PLoS One
  
  Volume: 6 Issue: 12 Pages: 1-14
- DOI
  10.1371/journal.pone.0029460
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500424, KAKENHI-PROJECT-23591228, KAKENHI-PROJECT-23592521, KAKENHI-PROJECT-23790974
[Journal Article] Association of olfactory dysfunction and brain metabolism in Parkinson's disease2011
- Author(s)
  Baba T, Takeda A, Kikuchi A, Hishio Y, Hosokai Y, Hirayama K, Hasegawa T, Sugeno N, Suzuki K, et al
- Journal Title
  
  Movement disorder
  
  Volume: 26 Issue: 4 Pages: 621-628
- DOI
  10.1002/mds.23602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300345, KAKENHI-PROJECT-22611002, KAKENHI-PROJECT-22791104, KAKENHI-PUBLICLY-23135502, KAKENHI-PROJECT-23591228, KAKENHI-PROJECT-23790974
[Journal Article] Differentiating Parkinson's disease from multiple system atrophy by [(123)I] meta-iodobenzylguanidine myocardial scintigraphy and olfactory test2011
- Author(s)
  Kikuchi A, Baba T, Hasegawa T, Sugeno N, Konno M, Takeda A
- Journal Title
  
  Parkinsonism Relat Disord
  
  Volume: 17 Pages: 698-700
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591228
[Journal Article] A Case of Late Onset Riboflavin-responsive Multiple Acyl-CoA Dehydrogenase Deficiency Manifesting as Recurrent Rhabdomyolysis and Acute Renal Failure2011
- Author(s)
  Izumi R, Suzuki N, Nagata M, Hasegawa T, Abe Y, Saito Y, Mochizuki H, Tateyama M, Aoki M
- Journal Title
  
  Internal Medicine
  
  Volume: 50 Pages: 2663-2668
- NAID
  130001288632
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591228
[Journal Article] α-synuclein facilitates the toxicity of oxidized catechol metabolites : Implications for selective neurodegeneration in Parkinson's disease.2006
- Author(s)
  Hasegawa T 他
- Journal Title
  
  FEBS Letters (in press)
- Data Source
  KAKENHI-PROJECT-16790483
[Journal Article] Neuro-Behcet's disease presenting initially as mesiotemporal lesions mimicking herpes simplex encephalitis.2005
- Author(s)
  Hasegawa T 他
- Journal Title
  
  European Journal of Neurology 12
  
  Pages: 660-662
- Data Source
  KAKENHI-PROJECT-16790483
[Journal Article] Transethmoidal intranasal meningoencephalocele in an adult with recurrent meningitis.2005
- Author(s)
  Hasegawa T 他
- Journal Title
  
  Journal of Critical Neuroscience 12
  
  Pages: 702-704
- Data Source
  KAKENHI-PROJECT-16790483
[Journal Article] Periodic episodes of aphasia as an unusual manifestation of partial status epilepticus.2005
- Author(s)
  Hasegawa T 他
- Journal Title
  
  Journal of Critical Neuroscience 12
  
  Pages: 820-822
- Data Source
  KAKENHI-PROJECT-16790483
[Journal Article] チロシナーゼ発現調節細胞を用いたカテコールアミン酸化物による神経細胞死の病態解析2004
- Author(s)
  長谷川隆文他
- Journal Title
  
  Progress in Medicine 24
  
  Pages: 445-452
- Data Source
  KAKENHI-PROJECT-16790483
[Journal Article] Accelerated formation of α-synuclein aggregates in differentiated SH-SY5Y neuroblastoma cells.2004
- Author(s)
  Hasegawa T 他
- Journal Title
  
  Brain Research 1013
  
  Pages: 51-9
- Data Source
  KAKENHI-PROJECT-16790483
[Presentation] エンドソーム輸送からαシヌクレイン伝播現象を解読する2023
- Author(s)
  長谷川隆文
- Organizer
  第42回認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07896
[Presentation] Hot Topics “Disease-modifying treatment of PD: What is the rate-limiting factor of drug discovery?”：Synuclein-targeting therapies in PD: what do we know and where are we headed?2023
- Author(s)
  Hasegawa T
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20K07896
[Presentation] Controversy1 ：それでもシヌクレイン抗体療法でPDは治療できる：「Yes」2023
- Author(s)
  長谷川隆文
- Organizer
  第17回パーキンソン病・運動障害疾患コングレス
- Data Source
  KAKENHI-PROJECT-23K06823
[Presentation] αシヌクレインに焦点を当てた診断・治療的アプローチ-Up to Date2023
- Author(s)
  長谷川隆文
- Organizer
  第41回日本神経治療学会
- Data Source
  KAKENHI-PROJECT-20K07896
[Presentation] Controversy1: それでもシヌクレイン抗体療法でPDは治療できる「Yes」の立場から2023
- Author(s)
  長谷川隆文
- Organizer
  第17回パーキンソン病・運動障害疾患コングレス/MDSJ
- Data Source
  KAKENHI-PROJECT-20K07896
[Presentation] 線維化αシヌクレインの細胞内取り込みに寄与する受容体探索2023
- Author(s)
  長谷川隆文
- Organizer
  第41回日本神経治療学会
- Data Source
  KAKENHI-PROJECT-23K06823
[Presentation] Impact of istradefylline on the onset of dyskinesia in Parkinson's Disease patients with wearing off: a randomized controlled study (ODYSSEI)2023
- Author(s)
  Tsuboi T, Hasegawa T, Shimo S, Kaneko S, Tomiyama M, Kashihara K, Chiu S, Yamaguchi T on behalf of the ODYSSEI study group.
- Organizer
  International Congress of Parkinson's Disease and Movement Disorders 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07896
[Presentation] Synuclein-targeting therapies in PD: what do we know and where are we headed?2023
- Author(s)
  Hasegawa T.
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-23K06823
[Presentation] エンドソーム輸送からαシヌクレイン伝播現象を解読する2023
- Author(s)
  長谷川隆文
- Organizer
  第42回認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-23K06823
[Presentation] How does alpha-synuclein transfer from cell to cell? A cell biological perspective.2023
- Author(s)
  Hasegawa Takafumi
- Organizer
  Takamatsu International Symposium for PD & MD in Tokyo 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07896
[Presentation] 蛋白凝集・伝播メカニズムからみたレビー小体病の多様性2022
- Author(s)
  長谷川隆文
- Organizer
  第46回日本高次脳機能障害学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07896
[Presentation] 細胞内輸送機構から迫るパーキンソン病の病態2022
- Author(s)
  長谷川隆文
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20K07896
[Presentation] Decoding the transcellular spreading of alpha-synuclein: The role of membrane trafficking.2022
- Author(s)
  Hasegawa Takafumi
- Organizer
  第16回パーキンソン病・運動障害疾患コングレス
- Invited
- Data Source
  KAKENHI-PROJECT-20K07896
[Presentation] ランチョンセミナー：COVID-19パンデミックから考えるαシヌクレインの生体機能と病態学.2021
- Author(s)
  長谷川隆文
- Organizer
  第62回日本神経病理学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07896
[Presentation] 免疫抗体療法の現状と未来－シヌクレインを標的とした免疫療法開発の現状2021
- Author(s)
  長谷川隆文
- Organizer
  第14回パーキンソン病・運動障害疾患コングレス
- Data Source
  KAKENHI-PROJECT-20K07896
[Presentation] パーキンソン病治療の進歩：α-synuclein凝集・伝播を標的としたPD疾患修飾療法開発の現況.2021
- Author(s)
  長谷川隆文
- Organizer
  第15回パーキンソン病・運動障害疾患コングレス
- Data Source
  KAKENHI-PROJECT-20K07896
[Presentation] パ－キンソン病修飾療法開発の現況.2021
- Author(s)
  長谷川隆文
- Organizer
  第39回日本神経治療学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07896
[Presentation] 蛋白伝播メカニズムから考えるレビー小体病の多様性2021
- Author(s)
  長谷川隆文
- Organizer
  第27回日本神経学会東北地方会生涯教育講演会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07896
[Presentation] 記念講演：「ここまでわかったパーキンソン病ー診療・研究の最前線」2021
- Author(s)
  長谷川隆文
- Organizer
  2021年度日本フンボルト協会東北支部総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07896
[Presentation] How does exogenous alpha-synuclein get access to the endogenous alpha-synuclein proteins?2020
- Author(s)
  Hasegawa T
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20K07896
[Presentation] 伝播現象から遺伝性病態まで：メンブレントラフィックが織りなすパーキンソン病の分子病態2020
- Author(s)
  長谷川隆文
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20K07896
[Presentation] 生命の恒常性を支えるメンブレントラフィック研究の最前線：メンブレントラフィックから探るパーキンソン病の分子病態2020
- Author(s)
  長谷川隆文
- Organizer
  第125回日本解剖学会総会・全国学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09744
[Presentation] Extracellular α-synuclein internalizes into dopaminergic neurons by hijacking flotillin-1-assisted dopamine transporter endocytosis2019
- Author(s)
  Hasegawa T, Kobayashi J, Sugeno N, Yoshida S, Ezura M, Kikuchi A, Takeda A, Aoki M.
- Organizer
  AD/PD2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09744
[Presentation] Extracellular α-synuclein enters dopaminergic cells by modulating flotillin-1-assisted dopamine transporter endocytosis.2019
- Author(s)
  Hasegawa T, Kobayashi J, Sugeno N, Yoshida S, Akiyama T, Fujimori K, Hatakeyama H, Miki Y, Kanzaki M, Wakabayashi K, Okano H, Aoki M.
- Organizer
  5th World Parkinson Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09744
[Presentation] オルガネラ間の連携破綻からみた神経疾患の発症メカニズム－メンブレントラフィック障害に着目したパーキンソン病の分子病態解析2019
- Author(s)
  長谷川隆文
- Organizer
  NEURO2019 第62回日本神経化学会大会・第42回日本神経科学大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09744
[Presentation] メンブレントラフィッキングの破綻とパーキンソン病－VPS35とDNAJC13を中心に2019
- Author(s)
  長谷川隆文
- Organizer
  第92回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09744
[Presentation] パーキンソン病の新規治療戦略－α-synuclein凝集・伝播を標的としたPD疾患修飾療法開発の現況2019
- Author(s)
  長谷川隆文
- Organizer
  第37回日本神経治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09744
[Presentation] Genotype-phenotype correlation of LRP10 mutations among familial Parkinson’s disease.2019
- Author(s)
  Daida K, Li Y, Funayama M, Ogaki K, Yoshino H, Kikuchi A, Hasegawa T, Nishioka K, Hattori N.
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K09744
[Presentation] Extracellular α-synuclein enters dopaminergic cells by modulating flotillin-1-assisted dopamine transporter endocytosis.2019
- Author(s)
  Hasegawa T, Kobayashi J, Sugeno N, Yoshida S, Ezura M, Kikuchi A, Takeda A, Aoki M.
- Organizer
  International Congress of Parkinosn’s Disease and Movement Disorders 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09744
[Presentation] Controversy：α-シヌクレイン凝集抑制治療は、疾患修飾治療になりうるか？－Yesの立場から2019
- Author(s)
  長谷川隆文
- Organizer
  第13回パーキンソン病・運動障害疾患コングレス
- Invited
- Data Source
  KAKENHI-PROJECT-17K09744
[Presentation] Extracellular α-synuclein enters dopaminergic neurons by modulating flotillin-1-assisted dopamine transporter endocytosis.2019
- Author(s)
  Hasegawa T, Kobayashi J, Sugeno N, Yoshida S, Ezura M, Kikuchi A, Takeda A, Aoki M.
- Organizer
  Japan-UK Neuroscience Symposium 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09744
[Presentation] 神経変性疾患の病態：レビー小体病の多様性は何処から生じるか？－蛋白伝播メカニズムから判ってきたこと2019
- Author(s)
  長谷川隆文
- Organizer
  第60回日本神経学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09744
[Presentation] 神経免疫と神経変性－シヌクレイノパチーを対象とした免疫療法の現況2019
- Author(s)
  長谷川隆文
- Organizer
  第31回日本神経免疫学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09744
[Presentation] More than just taking out the garbage-Expanding landscape of autophagy and lysosome function in neurological diseases. “Traffic jam in a cell”－Endo-lysosomal dysfunction as a convergent mechanism of neurodegenerative diseases.2019
- Author(s)
  Hasegawa T
- Organizer
  第60回日本神経学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09744
[Presentation] Extracellular α-synuclein enters dopaminergic neurons by modulating flotillin-1-assisted dopamine transporter endocytosis.2018
- Author(s)
  Hasegawa T, Kobayashi J, Sugeno N, Yoshida S, Ezura M, Kikuchi A, Takeda A, Aoki M.
- Organizer
  Japan-UK Neuroscience Symposium 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05683
[Presentation] 難病病態解明と新治療法：異常タンパク伝播－分子病態から考えるパーキンソン病の新規治療戦略2018
- Author(s)
  長谷川隆文
- Organizer
  第6回日本難病医療ネットワーク学会
- Data Source
  KAKENHI-PUBLICLY-17H05683
[Presentation] 神経化学からみた神経疾患 -ベンチとベットサイドの間：パーキンソン病の共通病態としてのエンドソーム輸送障害2018
- Author(s)
  長谷川隆文
- Organizer
  第61回日本神経化学会大会・第40回日本生物学的精神医学会合同大会
- Data Source
  KAKENHI-PUBLICLY-17H05683
[Presentation] Extracellular α-synuclein internalizes into cells by modulating flotillin-1-assisted endocytosis of DAT.2018
- Author(s)
  Hasegawa T, Kobayashi J, Sugeno N, Yoshida S, Ezura M, Kikuchi A, Takeda A, Aoki M.
- Organizer
  Neuroscience 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09744
[Presentation] Extracellular α-synuclein internalizes into cells by modulating flotillin-1-assisted endocytosis of DAT.2018
- Author(s)
  Hasegawa T, Kobayashi J, Sugeno N, Yoshida S, Ezura M, Kikuchi A, Takeda A, Aoki M
- Organizer
  Neuroscience 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05683
[Presentation] 難病病態解明と新治療法：異常タンパク伝播－分子病態から考えるパーキンソン病の新規治療戦略2018
- Author(s)
  長谷川隆文
- Organizer
  第6回日本難病医療ネットワーク学会
- Data Source
  KAKENHI-PROJECT-17K09744
[Presentation] Prion-like phenomenon：from myth to reality：Endosomal pathway: a molecular basis for prion-like phenomenon in synucleinopathy.2018
- Author(s)
  長谷川隆文
- Organizer
  第59回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K09744
[Presentation] Prion-like phenomenon：from myth to reality：Endosomal pathway: a molecular basis for prion-like phenomenon in synucleinopathy.2018
- Author(s)
  長谷川隆文
- Organizer
  第59回日本神経学会学術大会
- Data Source
  KAKENHI-PUBLICLY-17H05683
[Presentation] 神経化学からみた神経疾患 -ベンチとベットサイドの間：パーキンソン病の共通病態としてのエンドソーム輸送障害2018
- Author(s)
  長谷川隆文
- Organizer
  第61回日本神経化学会大会・第40回日本生物学的精神医学会合同大会
- Data Source
  KAKENHI-PROJECT-17K09744
[Presentation] パーキンソン病の最新知見－蛋白伝播メカニズムから考えるレビー小体病の多様性2018
- Author(s)
  長谷川隆文
- Organizer
  第41回日本神経科学大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09744
[Presentation] ランチョンセミナー：パーキンソン病の最新知見－蛋白伝播メカニズムから考えるレビー小体病の多様性2018
- Author(s)
  長谷川隆文
- Organizer
  第41回日本神経科学大会
- Data Source
  KAKENHI-PUBLICLY-17H05683
[Presentation] Extracellular α-synuclein internalizes into dopaminergic neurons by hijacking flotillin-1-assisted dopamine transporter endocytosis2018
- Author(s)
  Hasegawa T, Kobayashi J, Sugeno N, Yoshida S, Ezura M, Kikuchi A, Takeda A, Aoki M.
- Organizer
  AD/PD 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05683
[Presentation] Mutant DNAJC13 modulates accumulation and toxicity of α-synuclein through altered endosomal trafficking in cell and fly models of Parkinson’s disease.2017
- Author(s)
  Hasegawa T, Yoshida S, Suzuki M, Sugeno N, Kobayashi J, Ezura M, Kikuchi A, Baba T, Takeda A, Mochizuki H, Nagai Y, Aoki M.
- Organizer
  The 21th International Congress of Parkinson's Disease and Movement Disorders, Vancouver, Canada
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09744
[Presentation] Parkinson’s disease-linked DNAJC13 mutation aggravates α-synuclein-induced neurotoxicity through alteration of endosomal trafficking.2017
- Author(s)
  Hasegawa T, Yoshida S, Suzuki M, Sugeno N, Kobayashi J, Ezura M, Kikuchi A, Baba T, Takeda A, Mochizuki H, Nagai Y, Aoki M.
- Organizer
  Neuroscience 2017, Washington DC, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09744
[Presentation] Parkinson’s disease-linked DNAJC13 mutation aggravates α-synuclein-induced neurotoxicity through alteration of endosomal trafficking.2017
- Author(s)
  Hasegawa T, Yoshida S, Suzuki M, Sugeno N, Kobayashi J, Ezura M, Kikuchi A, Baba T, Takeda A, Mochizuki H, Nagai Y, Aoki M.
- Organizer
  Neuroscience 2017, Washington DC, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05683
[Presentation] Endosomal pathway: a key regulator for prion-like phenomenon in synucleinopathy2017
- Author(s)
  長谷川隆文
- Organizer
  第60回日本神経化学会大会、仙台
- Invited
- Data Source
  KAKENHI-PROJECT-17K09744
[Presentation] Parkinson's disease-linked DNAJC13 mutation aggravates α-synuclein-induced neurotoxicity through alteration of endosomal trafficking.2017
- Author(s)
  Hasegawa T, Yoshida S, Suzuki M, Sugeno N, Kobayashi J, Ezura M, Kikuchi A, Baba T, Takeda A, Mochizuki H, Nagai Y, Aoki M.
- Organizer
  XXIII World Congress of Neurology, Kyoto, Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09744
[Presentation] Parkinson's disease-linked DNAJC13 mutation aggravates α-synuclein-induced neurotoxicity through alteration of endosomal trafficking.2017
- Author(s)
  Hasegawa T, Yoshida S, Suzuki M, Sugeno N, Kobayashi J, Ezura M, Kikuchi A, Baba T, Takeda A, Mochizuki H, Nagai Y, Aoki M.
- Organizer
  XXIII World Congress of Neurology, Kyoto, Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05683
[Presentation] Mutant DNAJC13 modulates accumulation and toxicity of α-synuclein through altered endosomal trafficking in cell and fly models of Parkinson’s disease.2017
- Author(s)
  Hasegawa T, Yoshida S, Suzuki M, Sugeno N, Kobayashi J, Ezura M, Kikuchi A, Baba T, Takeda A, Mochizuki H, Nagai Y, Aoki M.
- Organizer
  The 21th International Congress of Parkinson's Disease and Movement Disorders, 2017, Vancouver, Canada
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05683
[Presentation] Deciphering the molecular mechanism behind the prion-like spread of α-synuclein.2017
- Author(s)
  Hasegawa T.
- Organizer
  The 11th International Conference on Complex Medical Engineering, Shenzhen, China
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05683
[Presentation] Deciphering the molecular mechanism behind the prion-like spread of α-synuclein.2017
- Author(s)
  Hasegawa T.
- Organizer
  The 11th International Conference on Complex Medical Engineering, Schenzhen, China
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09744
[Presentation] Membrane Trafficking Illuminates a Path to Parkinson’s Disease2017
- Author(s)
  Hasegawa T.
- Organizer
  JNS2017Satellite Symposium-Protein Misfolding Disease, Sendai, Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05683
[Presentation] Forebrain-specific knockout of ESCRT-0/Hrs disrupts protein quality control and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways2016
- Author(s)
  Oshima R, Hasegawa T, Tamai K, Takeda A, Tanaka N, Aoki M
- Organizer
  The 5th Asian and Oceanian Parkinson’s Disease and Movement Disorders
- Place of Presentation
  マニラ、フィリピン
- Year and Date
  2016-03-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461263
[Presentation] ESCRT-0 dysfunction compromises autophagic degradation of protein aggregates and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways.2016
- Author(s)
  Hasegawa T, Oshima R, Tamai K, Takeda A, Tanaka N, Aoki M
- Organizer
  The 20th International Congress of Parkinson's Disease and Movement Disorders
- Place of Presentation
  ベルリン、ドイツ
- Year and Date
  2016-06-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461263
[Presentation] Membrane trafficking in neuronal maintenance and degeneration.2016
- Author(s)
  Hasegawa T
- Organizer
  Brain Protein Aging and Dementia Control: 1st International Workshop 2016
- Place of Presentation
  名古屋（名古屋大学鶴友会館）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461263
[Presentation] Movement disorders update: Membrane trafficking and Parkinson’s disease.2016
- Author(s)
  長谷川隆文
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸（神戸コンベンションセンター）
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-26461263
[Presentation] MSAの治療実現のために、何が必要か？: MSAの病態修飾療法－課題と希望.2016
- Author(s)
  長谷川隆文
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸（神戸コンベンションセンター）
- Data Source
  KAKENHI-PROJECT-26461263
[Presentation] 動物モデルと治療薬の展望：異常タンパク伝播機構から考えるシヌクレイノパチー疾患修飾療法の展望.2016
- Author(s)
  長谷川隆文
- Organizer
  第10回パーキンソン病・運動障害疾患コングレス
- Place of Presentation
  京都（京都ホテルオークラ）
- Year and Date
  2016-10-06
- Invited
- Data Source
  KAKENHI-PROJECT-26461263
[Presentation] 教育講演：「αシヌクレインと細胞毒性発現メカニズム」αシヌクレインプリオン仮説の基礎－αシヌクレイン吸収・分泌のメカニズム2015
- Author(s)
  長谷川隆文
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  新潟コンベンションセンター（新潟）
- Year and Date
  2015-05-20
- Invited
- Data Source
  KAKENHI-PROJECT-26461263
[Presentation] Knockdown of ESCRT-0 disrupts protein quality control and promotes ER stress-mediated neuronal cell death2015
- Author(s)
  Hasegawa T, Oshima R, Sugeno N, Tamai K, Kikuchi A, Takeda A, Tanaka N, Aoki M
- Organizer
  Neuroscience 2015
- Place of Presentation
  シカゴ、米国
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461263
[Presentation] パーキンソン病における髄液エキソソーム中microRNA発現プロファイリング2015
- Author(s)
  長谷川隆文
- Organizer
  第33回日本神経治療学会総会
- Place of Presentation
  名古屋国際会議場（名古屋）
- Year and Date
  2015-11-27
- Data Source
  KAKENHI-PROJECT-26461263
[Presentation] CSF derived exosomal microRNA profile in patients with Parkinson’s disease2015
- Author(s)
  Hasegawa T, Sugeno N, Akio Kikuchi1, Oshima R, Yoshida S, Takeda A, Aoki M
- Organizer
  The MDS 19th International Congress of Parkinson's Disease and Movement Disorders
- Place of Presentation
  サンディエゴ、米国
- Year and Date
  2015-06-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461263
[Presentation] パーキンソン病における脳内α-シヌクレイン蛋白凝集体のPETによる画像化2015
- Author(s)
  198)菊池昭夫、馬場徹、長谷川隆文、菅野直人、今野昌俊、三浦永美子、大嶋龍司、岡村信行、古本祥三、谷内一彦、田代学、工藤幸司、糸山泰人、武田篤、青木正志
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  新潟
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-24390219
[Presentation] ER stress and Parkinson’s disease: relevance to neurodegeneration.2014
- Author(s)
  Hasegawa T
- Organizer
  The 87th Annual Meeting of the Japanese Pharmacological Society
- Place of Presentation
  Sendai, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] K63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized alpha-synuclein2014
- Author(s)
  Sugeno N, Hasegawa T, Tanaka N, Fukuda M, Wakabayashi K, Oshima R, Konno M, Miura E, Kikuchi A, Baba T, Anan T, Nakao M, Geisler S, Aoki M, Takeda A.
- Organizer
  18th International Congress of Parkinson's Disease and Movement Disorders
- Place of Presentation
  スウェーデン、ストックホルム
- Data Source
  KAKENHI-PROJECT-25461264
[Presentation] RNAi-mediated silencing of VPS35 exacerbates phenotypic and locomotor abnormalities in α-synuclein transgenic Drosophila.2013
- Author(s)
  Hasegawa T, Konno M, Miura E, Sugeno N, Nagai Y, Fujikake N, Suzuki M, Kikuchi A, Aoki M, Takeda A.
- Organizer
  The MDS 17th International Congress of Parkinson's Disease and Movement Disorders
- Place of Presentation
  Sydney, Australia
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] Search for rare-variant risks of Parkinson's disease by sequencing of candidate genes and exome sequencing2013
- Author(s)
  Satake W. Ando Y. Tomiyama H. Takeda A. Hasegawa K. Yamamoto M. Murata M. Hattori N. Toda T.
- Organizer
  17th International Congress of Parkinson’s Disease and Movement Disorders
- Place of Presentation
  Sydney, Australia
- Data Source
  KAKENHI-PROJECT-24390219
[Presentation] Nedd4 E3 ubiquitin ligase facilitates the endosomal targeting of alpha-synuclein2013
- Author(s)
  Sugeno N. Hasegawa T. Konno M. Miura E. Kikuchi A. Aoki M. Takeda A.
- Organizer
  17th International Congress of Parkinson’s Disease and Movement Disorders
- Place of Presentation
  Sydney, Australia
- Data Source
  KAKENHI-PROJECT-24390219
[Presentation] Recent progress in multiple system atrophy-“Pathogenesis of multiple system atrophy.”2013
- Author(s)
  Hasegawa T
- Organizer
  54th Annual Meeting of the Japanese Society of Neurology
- Place of Presentation
  Tokyo, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] RNAi-mediated knockdown of VPS35 impairs α-synuclein degradation by inhibiting the maturation of cathepsin D2013
- Author(s)
  Miura E. Hasegawa T. Konno M. Sugeno N. Kikuchi A. Baba T. Aoki M. Takeda A.
- Organizer
  17th International Congress of Parkinson’s Disease and Movement Disorders
- Place of Presentation
  Sydney, Australia
- Data Source
  KAKENHI-PROJECT-24390219
[Presentation] The E3 ubiquitin ligase Nedd4 facilitates the endosomal targeting of extracellular alpha-synuclein.2013
- Author(s)
  Sugeno N, Hasegawa T, Konno M, Miura E, Oshima R, Kikuchi A, Aoki M, Takeda A.
- Organizer
  Neuroscience 2013
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] Regulation of alpha-synuclein internalization and secretion : what do we know, and where are we headed?2013
- Author(s)
  Hasegawa T
- Organizer
  7^<th> International Conference on alpha-Synuclein in Parkinson's Disease and Related Neurodegenerative Diseases : From Mechanisms to Therapeutic Strategies
- Place of Presentation
  ドバイ, UAE
- Year and Date
  2013-03-02
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] RNAi-mediated knockdown of VPS35 impairs α-synuclein degradation by inhibiting the maturation of cathepsin D2013
- Author(s)
  Takafumi Hasegawa, Masatoshi Konno, Emiko Miura, Naoto Sugeno, Yoshitaka Nagai, Nobuhiro Fujikake, Mari Suzuki, Akio Kikuchi, Masashi Aoki, Atsushi Takeda
- Organizer
  AD/PD2013
- Place of Presentation
  フローレンス、イタリア
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] E3 ubiquitin ligase Nedd4はαシヌクレインのエンドソームへのターゲッティングに重要である2013
- Author(s)
  菅野直人、長谷川隆文、今野昌俊、三浦永美子、菊池昭夫、青木正志、武田篤
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京、東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-25461264
[Presentation] RNAi-mediated silencing of VPS35 exacerbates phenotypic and locomotor abnormalities in alpha-synuclein transgenic drosophila2013
- Author(s)
  Hasegawa T, Konno M, Miura E, Sugeno N, Nagai Y, Fujikake N, Suzuki M, Kikuchi A, Aoki M, Takeda A
- Organizer
  17th International Congress of Parkinson's Disease and Related Disorders
- Place of Presentation
  シドニー,オーストラリア
- Year and Date
  2013-06-17
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] DNAJC6遺伝子異常によるパーキンソン病発症機序解析2013
- Author(s)
  長谷川隆文、菅野直人、今野昌俊、三浦永美子、三好耕、浅沼幹人、菊池昭夫、青木正志、武田篤
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] RNAi-mediated knockdown of VPS35 impairs α-synuclein degradation by inhibiting the maturation of cathepsin D2013
- Author(s)
  Hasegawa T, Konno M, Miura M, Suzuki M, Sugeno N, Nagai Y, Fujikake N, Kikuchi A, Aoki M, Takeda A.
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] E3 ubiquitin ligase Nedd4 is a key regulator of the endosomal targeting of a-synuclein2013
- Author(s)
  Naoto Sugeno, Takafumi Hasegawa, Masatoshi Konno, Emiko Miura, Akio Kikuchi, Masashi Aoki, Atsushi Takeda
- Organizer
  17th International Congress of Parkinson's Disease and Movement Disorders
- Place of Presentation
  オーストラリア、シドニー
- Data Source
  KAKENHI-PROJECT-25461264
[Presentation] Regulation of alpha-synuclein internalization and secretion: what do we know, and where are we headed?2013
- Author(s)
  Takafumi Hasegawa
- Organizer
  Alpha-Synuclein in Parkinson's Disease & Related Neurodegenerative Diseases: From Mechanisms to Therapeutic Strategies
- Place of Presentation
  ドバイ、UAE
- Invited
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] αSYN蓄積・神経変性におけるESCRT機能異常の関与2013
- Author(s)
  大嶋龍司、長谷川隆文、田中伸幸、玉井恵一、菅野直人、三浦永美子、今野昌俊、菊池昭夫、青木正志、武田篤
- Organizer
  第7回パーキンソン病・運動障害疾患コングレス
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] RNAi-mediated knockdown of VPS35 impairs α-synuclein degradation by inhibiting the maturation of cathepsin D2013
- Author(s)
  Hasegawa T, Konno M, Miura M, Suzuki M, Sugeno N, Nagai Y, Fujikake N, Kikuchi A, Aoki M, Takeda A.
- Organizer
  XX World Congress on Parkinson's Disease and Related Disorders
- Place of Presentation
  Geneva, Switzerland
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] Nedd4 E3 ubiquitin ligase facilitates the endosomal targeting of extracellular alpha-synuclein2013
- Author(s)
  Naoto Sugeno, Takafumi Hasegawa, Masatoshi Konno, Emiko Miura, Akio Kikuchi, Masashi Aoki, Atsushi Takeda
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜、パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25461264
[Presentation] αシヌクレイン細胞内取り込みはダイナミン阻害により抑制される2013
- Author(s)
  長谷川隆文、今野昌俊、菅野直人、三浦永美子、菊池昭夫、青木正志、武田篤
- Organizer
  平成24年度　運動失調症の病態解明と治療法開発に関する研究班班会議
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] Differentiating Parkinson's disease from multiple system atrophy by [123I] meta-iodobenzylguanidine myocardial scintigraphy and olfactory test2013
- Author(s)
  Kikuchi A. Baba T. Hasegawa T. Sugeno N. Konno M. Aoki M. Takeda A.
- Organizer
  17th International Congress of Parkinson’s Disease and Movement Disorders
- Place of Presentation
  Sydney, Australia
- Data Source
  KAKENHI-PROJECT-24390219
[Presentation] RNAi-mediated knockdown of VPS35 impairsα-synuclein degradation by inhibiting the maturation of cathepsin D2013
- Author(s)
  Hasegawa T, Konno M, Miura E, Sugeno N, Nagai Y, Fujikake N, Suzuki M, Kikuchi A, Aoki M, Takeda A
- Organizer
  The 11th International Conference on Alzheimer's & Parkinson's Diseases (AD/PD 2013)
- Place of Presentation
  フローレンス,イタリア
- Year and Date
  2013-03-07
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] ショウジョウバエモデルを用いたVPS35遺伝子異常によるパーキンソン病発症機構の解析2013
- Author(s)
  今野昌俊、長谷川隆文、鈴木マリ、藤掛伸宏、永井義隆、三浦永美子、菅野直人、大嶋龍司、菊池昭夫、青木正志、武田篤
- Organizer
  第7回パーキンソン病・運動障害疾患コングレス
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] RNAi-mediated silencing of VPS35 exacerbates phenotypic and locomotor abnormalities in α-synuclein transgenic drosophila2013
- Author(s)
  Hasegawa T. Konno M. Miura E. Sugeno N. Nagai Y. Fujikake N. Suzuki M. Kikuchi A. Aoki M. Takeda A.
- Organizer
  17th International Congress of Parkinson’s Disease and Movement Disorders
- Place of Presentation
  Sydney, Australia
- Data Source
  KAKENHI-PROJECT-24390219
[Presentation] K63-linked ubiquitination by Nedd4 facilitates endosomal sequestration of internalized α-synuclein2013
- Author(s)
  Naoto Sugeno, Takafumi Hasegawa, Ryuji Oshima, Nobuyuki Tanaka, Masashi Konno, Emiko Miura, Akio Kikuchi, Toru Baba, Mitsunori Fukuda, Tadashi Anan, Mitsuyoshi Nakao, Sven Geisler, Masashi Aoki and Atsushi Takeda
- Organizer
  Neuroscience 2013
- Place of Presentation
  アメリカ合衆国、サン・ディエゴ
- Data Source
  KAKENHI-PROJECT-25461264
[Presentation] E3ユビキチンライゲースNedd4は細胞外αシヌクレインのエンドソームへのターゲッティングを制御する2013
- Author(s)
  菅野直人、長谷川隆文、今野昌俊、三浦永美子、大嶋龍司、菊池昭夫、青木正志、武田篤
- Organizer
  第7回パーキンソン病・運動障害疾患コングレス
- Place of Presentation
  東京、京王プラザホテル
- Data Source
  KAKENHI-PROJECT-25461264
[Presentation] レトロマー障害はカテプシンD成熟障害を介しα-シヌクレイン蓄積を誘導する2013
- Author(s)
  三浦永美子、長谷川隆文、今野昌俊、菅野直人、大嶋龍司、菊池昭夫、青木正志、武田篤
- Organizer
  第7回パーキンソン病・運動障害疾患コングレス
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] Suppression of dynamin GTPase decreases alpha-Synuclein uptake by neuronal and oligodendroglial Cells2012
- Author(s)
  Takafumi Hasegawa
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] Severe olfactory dysfunction is predictive of dementia associated with Parkinson's disease : A 3-year longitudinal study2012
- Author(s)
  Baba T., Kikuchi A., Hirayama K., Nishio Y., Hosokai Y., Kanno S., Hasegawa T., Sugeno N., Konno M., Miura E., Mori E., Takeda A.
- Organizer
  16th International Congress of Parkinson's Disease and Movement Disorders
- Place of Presentation
  Dublin, Ireland
- Data Source
  KAKENHI-PROJECT-24390219
[Presentation] αシヌクレインのリソソーム移行および細胞外分泌はAAA型ATPase VPS4により制御される2012
- Author(s)
  長谷川隆文、今野昌俊、三浦永美子、馬場徹、菅野直人、菊池昭夫、青木正志、武田篤
- Organizer
  第53回日本神経学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] The AAA-ATPase VPS4 regulates Extracellular Secretion and Lysosomal Targeting of Alpha-synuclein2012
- Author(s)
  Hasegawa T., Konno M, Baba T, Sugeno N, Kikuchi A, Miura E, Takeda A
- Organizer
  NRF-JSPS Asian Science Seminar
- Place of Presentation
  ソウル,韓国
- Year and Date
  2012-02-14
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] Suppression of Dynamin GTPase Activity Decreases α-synuclein Uptake in Neuronal and Oligodendroglial Cells2012
- Author(s)
  Takafumi Hasegawa, Masatoshi Konno, Naoto Sugeno, Emiko Miura, Toru Baba, Akio Kikuchi, Masashi Aoki, Atsushi Takeda
- Organizer
  第17回武田科学振興財団生命科学シンポジウム
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] The AAA-ATPase VPS4 Regulates Extracellular Secretion and Lysosomal Targeting of Alpha-synuclein2012
- Author(s)
  Hasegawa T, Konno M, Baba T, Sugeno N, Kikuchi A, Miura E, Takeda A
- Organizer
  NRF-JSPS Asian Science Seminar 2012
- Place of Presentation
  ソウル、韓国
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of α-synuclein2012
- Author(s)
  Hasegawa T., Konno M., Baba T., Sugeno N., Kikuchi A., Miura E., Takeda A.
- Organizer
  16th International Congress of Parkinson's Disease and Movement Disorders
- Place of Presentation
  Dublin, Ireland
- Data Source
  KAKENHI-PROJECT-24390219
[Presentation] α-synucleinの細胞間Propagationの機序2012
- Author(s)
  長谷川隆文
- Organizer
  厚労科研神経変性疾患に関する調査研究班　H24年度ワークショップ
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] Dynamin GTPase activity decreases alpha-synuclein uptake in neuronal and oligodendroglial cells2012
- Author(s)
  Konno M., Hasegawa T., Baba T., Miura E., Sugeno N., Kikuchi A., Aoki M., Takeda A.
- Organizer
  16th International Congress of Parkinson's Disease and Movement Disorders
- Place of Presentation
  Dublin, Ireland
- Data Source
  KAKENHI-PROJECT-24390219
[Presentation] ショウジョウバエモデルを用いたVps35遺伝子異常によるパーキンソン病病態の解析2012
- Author(s)
  長谷川隆文、今野昌俊、三浦永美子、菅野直人、永井義隆、藤掛伸宏、鈴木マリ、菊池昭夫、馬場徹、青木正志、武田篤
- Organizer
  平成24年度第6回パーキンソン病・運動障害疾患コングレス
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] α-synuclein細胞間伝播に関与する細胞内小胞輸送系の解明2012
- Author(s)
  長谷川隆文
- Organizer
  平成24年度第6回パーキンソン病・運動障害疾患コングレス
- Place of Presentation
  京都
- Invited
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] α-synuclein細胞間伝播に関与する細胞内小胞輸送系の解明2012
- Author(s)
  長谷川隆文
- Organizer
  第19回カテコールアミンと神経疾患研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] Japanese 2nd GWAS identifies strong association at a novel risk locus and MCCC1 for Parkinson's disease2012
- Author(s)
  Satake W., Yamamoto K, Ando Y., Takeda A., Tomiyama H., Kawakami H., Hasegawa K., Obata F., Watanabe M., Tamaoka A., Nakashima K., Sakoda S., Yamamoto M., Hattori N., Murata M., Nakamura Y., Toda T.
- Organizer
  16th International Congress of Parkinson's Disease and Movement Disorders
- Place of Presentation
  Dublin, Ireland
- Data Source
  KAKENHI-PROJECT-24390219
[Presentation] αシヌクレイン細胞間伝播はダイナミン機能阻害により抑制される2012
- Author(s)
  長谷川隆文、今野昌俊、三浦永美子、菅野直人、菊池昭夫、青木正志、武田篤
- Organizer
  第30回日本神経治療学会総会
- Place of Presentation
  北九州
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] Suppression of Dynamin GTPase Activity Decreasesα-synuclein Uptake in Neuronal and Oligodendroglial Cells2012
- Author(s)
  Hasegawa T, Konno M, Sugeno N, Miura E, Baba T, Kikuchi A, Aoki M, Takeda A
- Organizer
  The 17th Takeda Science Foundation Symposium on Bioscience."Therapeutic Approach for Neurodegenerative Diseases : Focusing on Alzheimer & Parkinson Diseases"
- Place of Presentation
  大阪
- Year and Date
  2012-12-07
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] Nedd4 participates in the internalization process of alpha-synuclein2012
- Author(s)
  Sugeno N., Hasegawa T., Konno M., Miura E., Baba T., Kikuchi A., Aoki M., Takeda A.
- Organizer
  16th International Congress of Parkinson's Disease and Movement Disorders
- Place of Presentation
  Dublin, Ireland
- Data Source
  KAKENHI-PROJECT-24390219
[Presentation] The AAA-ATPase VPS4 Regulates Extracellular Secretion and Lysosomal Targeting of α-synuclein2012
- Author(s)
  Takafumi Hasegawa, Masatoshi Konno, Toru Baba, Naoto Sugeno, Akio Kikuchi, Emiko Miura, Atsushi Takeda
- Organizer
  16th International Congress of Parkinson's Disease and Movement Disorders
- Place of Presentation
  ダブリン、アイルランド
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] The AAA-ATPase VPS4 Regulates Extracellular Secretion and Lysosomal Targeting ofα-synuclein2012
- Author(s)
  Hasegawa T, Konno M, Baba T, Sugeno N, Kikuchi A, Miura E, Takeda A
- Organizer
  The 16th International Congress of Parkinson's Disease and Movement Disorders
- Place of Presentation
  ダブリン,アイルランド
- Year and Date
  2012-06-18
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] Role of TPPP/p25 on alpha-synuclein-mediated oligodendroglial degeneration and the protective effect of SIRT2 inhibition in a cellular model of multiple system atrophy2011
- Author(s)
  Hasegawa T, Baba T, Michiko Kobayashi, Konno M, Sugeno N, Kikuchi A, Takeda A
- Organizer
  15th International Congress of Parkinson's Disease and Movement Disorders
- Place of Presentation
  トロント、カナダ
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] MVB sorting機構はα-synuclein分泌・ライソゾーム移行に関与する2011
- Author(s)
  長谷川隆文、今野昌俊、馬場徹、菅野直人、菊池昭夫、若林孝一、武田篤
- Organizer
  第5回パーキンソン病・運動障害疾患コングレス
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] 培養細胞系を用いたα-synucleinプリオン仮説の分子病態解析2011
- Author(s)
  長谷川隆文、今野昌俊、馬場徹、菅野直人、菊池昭夫、武田篤
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] シンポジウム　パーキンソン病ー病態ー2011
- Author(s)
  長谷川隆文
- Organizer
  第52回日本神経学会学術大会(招待講演)
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] アルファシヌクレインの細胞外分泌・ライソゾーム移行を制御する細胞内膜動輸送系の探索2011
- Author(s)
  長谷川隆文、今野昌俊、馬場徹、菅野直人、菊池昭夫、武田篤
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23591228
[Presentation] Functional ESCRT machinery is required for the clearance of aggregate-prone proteins associated with neurodegenerative diseases.
- Author(s)
  Hasegawa T
- Organizer
  th Asian and Oceanian Parkinson's disease and movement disorders congress
- Place of Presentation
  Pattaya, Thailand
- Year and Date
  2014-11-28 – 2014-11-30
- Data Source
  KAKENHI-PROJECT-26461263
[Presentation] Role of ESCRT machinery in the clearance of aggregate-prone proteins associa ted with neurodegenerative diseases.
- Author(s)
  Hasegawa T
- Organizer
  第87回生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26461263
[Presentation] Exome sequencing of Parkinson's disease in order to identify genetic variants with high disease-risk
- Author(s)
  Satake W. Ando Y. Tomiyama H. Kashihara K. Mochizuki H. Murayama S. Takeda A. Hasegawa K. Tsuji S. Yamamoto M. Murata M. Hattori N. Toda T.
- Organizer
  18th International Congress of Parkinson’s Disease and Movement Disorders
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2014-06-07 – 2014-06-12
- Data Source
  KAKENHI-PROJECT-24390219
[Presentation] Aberrant Vesicular Trafficking In Parkinson’s disease.
- Author(s)
  Hasegawa T
- Organizer
  The 2nd East Asia German Alumni Symposia in Life Science
- Place of Presentation
  Taipei, Taiwan
- Year and Date
  2014-10-17 – 2014-10-19
- Invited
- Data Source
  KAKENHI-PROJECT-26461263
[Presentation] Vesicular trafficking defect in the pathogenesis of Parkinson’s disease.
- Author(s)
  Hasegawa T
- Organizer
  2014 ICME International Conference on Complex Medical Engineering
- Place of Presentation
  Taipei, Taiwan
- Year and Date
  2014-07-26 – 2014-07-29
- Invited
- Data Source
  KAKENHI-PROJECT-26461263
[Presentation] Nedd4 regulates internalization and endosomal targeting of alpha-synuclein.
- Author(s)
  Hasegawa T, Sugeno N, Tanaka N, Fukuda M, Wakabayashi K, Oshima R, Konno M, Miura E, Kikuchi A, Baba T, Anan T, Nakao M, Geisler S, Takeda A, Aoki M
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26461263
[Presentation] Functional ESCRT machinery is required for the clearance of aggregate-prone proteins associated with neurodegenerative diseases
- Author(s)
  Oshima R. Hasegawa T. Sugeno N. Konno M. Miura E. Kikuchi A. Tamai K. Takeda A. Tanaka N. Aoki M.
- Organizer
  18th International Congress of Parkinson’s Disease and Movement Disorders
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2014-06-07 – 2014-06-12
- Data Source
  KAKENHI-PROJECT-24390219
[Presentation] VPS35 dysfunction impairs lysosomal degradation of [alpha]-synuclein and exacerbates neurotoxicity in a drosophila model of Parkinson's disease.
- Author(s)
  Hasegawa T
- Organizer
  The MDS 18th International Congress of Parkinson's Disease and Movement Disorders
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2014-06-08 – 2014-06-12
- Data Source
  KAKENHI-PROJECT-26461263
[Presentation] In vivo visualization of α-synuclein deposition by carbon-11-labeled 2-(2-[2-dimethylaminothiazol-5-yl]ethenyl)−6-(2-[fluoro]ethoxy)benzoxazole positron emission tomography in Parkinson's disease
- Author(s)
  Kikuchi A. Okamura N. Tashiro M. Hasegawa T. Sugeno N. Baba T. Konno M. Miura E. Oshima R. Furumoto S. Funaki Y. Iwata R. Takahashi S. Fukuda H. Arai H. Kudo Y. Yanai K. Itoyama Y. Aoki M. Takeda A.
- Organizer
  18th International Congress of Parkinson’s Disease and Movement Disorders
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2014-06-07 – 2014-06-12
- Data Source
  KAKENHI-PROJECT-24390219
[Presentation] Retromer dysfunction as an emerging mechanism of Parkinson's disease.
- Author(s)
  Hasegawa T
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Invited
- Data Source
  KAKENHI-PROJECT-26461263
[Presentation] K63-linked ubiquitination by Nedd4 facilitates endosomal sequestration of internalized alpha-synuclein, 18th International Congress of Parkinson’s Disease and Movement Disorders
- Author(s)
  Sugeno N. Hasegawa T. Tanaka N. Oshima R. Konno M. Miura E. Kikuchi A. Baba T. Fukuda M. Geisler S. Aoki M. Takeda A.,
- Organizer
  18th International Congress of Parkinson’s Disease and Movement Disorders
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2014-06-07 – 2014-06-12
- Data Source
  KAKENHI-PROJECT-24390219
[Presentation] How does exogenous alpha-synuclein get access to the endogenous alpha-synuclein proteins?
- Author(s)
  Hasegawa T
- Organizer
  2015 MDS course Alpha-Synuclein: The Gateway to Parkinsonism
- Place of Presentation
  Innsbruck, Austria
- Year and Date
  2015-02-11 – 2015-02-13
- Invited
- Data Source
  KAKENHI-PROJECT-26461263

1. TAKEDA Atsushi (70261534)

# of Collaborated Projects: 3 results

# of Collaborated Products: 59 results
2. Sugeno Naoto (30509550)

# of Collaborated Projects: 3 results

# of Collaborated Products: 31 results
3. NAGAI Yoshitaka (60335354)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
4. KIKUCHI Akio (80463785)

# of Collaborated Projects: 1 results

# of Collaborated Products: 24 results
5. HAYASHI Yuichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. HOSOKAI Yoshiyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 相澤修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 青木正志

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. 金山直樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 石岡俊之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 若林孝一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 森文秋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 鈴木匡子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. 仙石錬平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hasegawa Takafumi 長谷川 隆文

HASEGAWA Takafumi 長谷川 隆文

長谷川 隆文 ハセガワ タカフミ

Research Projects

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Co-Researchers

エンドソームダイナミクスから迫るパ－キンソン病の分子病態と新規治療標的Principal Investigator

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Development of novel synucleinopathy treatment targeting the receptor for alpha-synuclein fibrilsPrincipal Investigator

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Zeroing in on membrane trafficking: its implication for molecular pathogenesis and curative therapy of Parkinson's diseasePrincipal Investigator

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Establishment of novel disease-modifying therapy for synucleinopathy targeting internalization of protein aggregatesPrincipal Investigator

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Zeroing in on aberrant membrane trafficking in molecular pathogenesis of Parkinson's diseasePrincipal Investigator

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内在化αシヌクレインにおけるESCRTを中心とした小胞輸送に関する研究

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Early diagnosis and treatment of Parkinson disease dementia

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Analysis of molecular mechanisms behind the prion hypothesis in synucleinopathyPrincipal Investigator

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酸化的ストレッサー存在下におけるαシヌクレイン凝集体形成と神経細胞死の関連Principal Investigator

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[Book] いま新薬で加速する神経変性疾患研究. タンパク質構造と病態3. 異常タンパク伝播を司るメンブレントラフィック機構2023

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[Book] 脳神経内科 特集I/認知症の病態・診断・治療7. Lewy小体病における蛋白伝播メカニズム2022

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[Book] 神経治療学 パ－キンソン病疾患修飾療法開発の現況2022

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[Book] Annual Review神経20222022

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Hasegawa Takafumi 長谷川隆文

HASEGAWA Takafumi 長谷川隆文

長谷川隆文ハセガワタカフミ

[Book] 脳神経内科　特集I/認知症の病態・診断・治療7. Lewy小体病における蛋白伝播メカニズム2022

[Book] 神経治療学　パ－キンソン病疾患修飾療法開発の現況2022

[Book] 非定型パーキンソニズム－基礎と臨床　III. 病態解明と治療法の確立に向けて　αシヌクレイン2019

[Journal Article] 特集頭蓋内の「流れ」と認知機能神経変性関連タンパクの細胞間伝播2023