NAGAYAMA Satoshi 長山聡

Researcher Number	70362499
Other IDs
External Links
Affiliation (Current)	2025: 京都大学, 医学研究科, 客員研究員 2025: 公益財団法人がん研究会, 有明病院大腸外科, 医員
Affiliation (based on the past Project Information) *help	2022 – 2024: 京都大学, 医学研究科, 客員研究員 2022: 公益財団法人がん研究会, 有明病院大腸外科, 医員 2015 – 2021: 公益財団法人がん研究会, 有明病院消化器外科, 医長 2017: 公益財団法人がん研究会, 有明病院消化器外科, 医長 2015: 公益財団法人がん研究会, 有明病院消化器外科, 医長 … More 2014 – 2015: 公益財団法人がん研究会, 大腸外科, 医長 2013: 公益財団法人がん研究会, その他部局等, その他 2013: 公益財団法人がん研究会, 有明病院消化器外科, 医長 2011 – 2012: 公益財団法人がん研究会, 有明病院消化器外科, 医長 2010: Kyoto University, 有明病院消化器外科, 医長 2010: 財団法人癌研究会, 消化器外科, 医長 2007 – 2009: 京都大学, 医学研究科, 助教 2003 – 2006: 京都大学, 医学研究科, 助手 2005: 京都大学, 大学院・医学研究科, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Digestive surgery / Tumor biology / Tumor biology Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 50010:Tumor biology-related / Tumor diagnostics / Digestive surgery / Basic Section 55010:General surgery and pediatric surgery-related / Complex Systems Disease Theory / Experimental pathology
Keywords	Principal Investigator 大腸癌 / 浸潤 / 抗体療法 / 大腸癌肝転移 / FZD10 / 播種細胞 / オルガノイド / 遺伝子変異 / 化学療法 / プロテオゲノムプロファイリング … More / 薬効評価 / 大腸癌細胞株 / 薬剤感受性 / 癌細胞株 / 癌幹細胞 / 発癌 / 大腸癌発生 / WNT伝達系 / Wnt伝達系 … More Except Principal Investigator 大腸がん / プロテオミクス / バイオマーカー / リン酸化プロテオミクス / 大腸癌 / シミュレーション / がん微小環境 / dPCR / 体細胞変異 / 患者由来オルガノイド / エクソソーム / リン酸化プロテオーム解析 / 肺がん / 早期診断 / DNAメチル化 / MRD / メチル化ctDNA / クロストーク / 共局在 / scRNA / VISIUM / 空間的シングルセル解析 / クロストーク遺伝子 / MSI-H大腸癌 / 空間的転写産物解析 / シングルセル解析 / 共局在細胞 / 抗原提示機構 / MSI-H大腸がん / 前がん病変 / 免疫寛容 / 空間的シングルセルトランスクリプトーム解析 / 空間的遺伝子発現分布 / 遺伝子発現 / 大腸癌遠隔転移 / 転移・再発 / リキッドバイオプシー / ctDNA / マルチターゲット / 再発 / メチル化 / モニタリング / リン酸プロテオミクス / 生検組織 / 精密医療 / がん多様性 / 化学療法耐性 / 大腸癌肝転移 / 遺伝的背景 / 遺伝学的背景 / 家族性大腸腺腫症 / MEK阻害剤 / IFN/STATシグナル / KRAS / 再発早期診断 / 小腸大腸肛門外科学 / 転移早期診断 / 腫瘍マーカー / プロテオミクス解析 / 薬剤耐性機序 / リン酸化タンパク / がん / リン酸化タンパク質 / EGFR阻害剤 / 薬効予測 / 癌転移 / gene therapy / Hydrodynamic method / NKT cell / Host immune defence / Colorectal cancer / 自然免疫 / hydrodynamics法 / 大腸直腸癌 / CpG配列 / 遺伝子治療 / NKT細胞 / 宿主免疫 / 直腸癌局所再発 / 遺伝子導入 / 血管成熟度 / hydrodynamics-based transfection procedure / RECK / VEGF / 腫瘍血管新生 / ELF3 / クローディン / 滑膜肉腫 / 上皮間葉転換 / 癌肉腫 Less

患者由来オルガノイド再構成モデルによる播種細胞からの顕在性転移巣の発生機序の解明Principal Investigator
- Principal Investigator
  
  長山聡
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kyoto University
メチル化ctDNAによる大腸がん根治術後再発早期診断の実装的モニタリング法の開発
- Principal Investigator
  
  大村洋文
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kyushu University
空間的シングルセル解析による大腸がん転移巣を形成するがん微小環境の解明
- Principal Investigator
  
  斉藤秀幸
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  独立行政法人国立病院機構高崎総合医療センター(臨床研究部)
  Gunma University
大腸がん細胞との共局在により悪性度と免疫寛容を獲得するがん微小環境の解明
- Principal Investigator
  
  三森功士
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kyushu University
The role of cellular diversity in the metastasis and recurrence of colorectal cancer
- Principal Investigator
  
  YAO Ryoji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Japanese Foundation for Cancer Research
網羅的変異タンパク質定量解析に基づく再発大腸癌の診断、治療法開発
- Principal Investigator
  
  植田幸嗣
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Japanese Foundation for Cancer Research
Elucidation of cancer diversity mechanism by analysis of phosphorylation signal using biopsy tissue and application to precision medicine
- Principal Investigator
  
  Tomonaga Takeshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
ctDNAメチル化検出を実装する新たなアプローチによる大腸癌再発早期診断法の確立
- Principal Investigator
  
  大津甫
- Project Period (FY)
  2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Kyushu University
Elucidation of chemoresistance-resistant signal mechanism of colon cancer liver metastasis
- Principal Investigator
  
  ADACHI JUN
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
Development of a novel therapy for colorectal cancers based on the gene mutation profiles.Principal Investigator
- Principal Investigator
  
  Nagayama Satoshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Japanese Foundation for Cancer Research
Genetic- and Somatic-regualtion of colorectal cancer
- Principal Investigator
  
  YAO Ryoji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Japanese Foundation for Cancer Research
Discovery of drug resistant mechnism by kinome analysis using patient derived cultured cells
- Principal Investigator
  
  Tomonaga Takeshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor diagnostics
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
Development of a diagnostic model for a risk of colorectal cancer recurrence
- Principal Investigator
  
  Ueda Koji
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Complex Systems Disease Theory
- Research Institution
  Japanese Foundation for Cancer Research
Early diagnosis of colon cancer metastasis by multifaceted proteome analysis of metastatic lesion tissue and exosome
- Principal Investigator
  
  Tomonaga Takeshi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
Biomarker discovery of colorectal cancer metastasis from cancer tissues and verification in plasma exosomes by targeted proteomics.
- Principal Investigator
  
  Shiromizu Takashi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor diagnostics
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
Discovery of druggable targets of colorectal cancers by genomic analysis with cancer stem-like cellsPrincipal Investigator
- Principal Investigator
  
  Nagayama Satoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Japanese Foundation for Cancer Research
Establishment of quantitation method for proteome-based phospho-signaling pathway and its application for prediction of drug effect monitoring
- Principal Investigator
  
  Tomonaga Takeshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor diagnostics
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
Functinal analysis of a novel gene involved in the progression of colorectal cancersPrincipal Investigator
- Principal Investigator
  
  NAGAYAMA satoshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Japanese Foundation for Cancer Research
A role of FZD10, a WNT receptor, in the colon carcinogenesis.Principal Investigator
- Principal Investigator
  
  NAGAYAMA Satoshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
腫瘍血管新生と低酸素環境を標的としたテーラーメード癌治療法の創出
- Principal Investigator
  
  MORI Akira
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
癌肉腫における上皮間葉二相性組織形成の分子機構
- Principal Investigator
  
  TOGUCHIDA Junya
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Kyoto University
大腸癌肝転移巣に対するFZD10を標的分子とした新規抗体療法の開発Principal Investigator
- Principal Investigator
  
  長山聡
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
Analysis of cytokine secretion in locally recurrent rectal cancer and host-immune enhancement by gene induction
- Principal Investigator
  
  ONODERA Hisashi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University

[Journal Article] Spatial and single-cell colocalisation analysis reveals MDK-mediated immunosuppressive environment with regulatory T cells in colorectal carcinogenesis2024
- Author(s)
  Hashimoto Masahiro、Kojima Yasuhiro et. al.
- Journal Title
  
  eBioMedicine
  
  Volume: 103 Pages: 105102-105102
- DOI
  10.1016/j.ebiom.2024.105102
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K16991, KAKENHI-PROJECT-22K08894, KAKENHI-PROJECT-22K09006, KAKENHI-PROJECT-23K06662, KAKENHI-PROJECT-23K08215, KAKENHI-PROJECT-21K07179, KAKENHI-PLANNED-23H04938, KAKENHI-PROJECT-23K24164, KAKENHI-PROJECT-23K24941
[Journal Article] Implementable assay for monitoring minimum residual disease after radical treatment for colorectal cancer.2024
- Author(s)
  Nakano T, Takao S, Dairaku K, Uno N, Low SA, Hashimoto M, Tsuda Y, Hisamatsu Y, Toshima T, Yonemura Y, Masuda T, Eto K, Ikegami T, Fukunaga Y, Niida A, Nagayama S, Mimori K.
- Journal Title
  
  Cancer Sci.
  
  Volume: - Issue: 6 Pages: 1989-2001
- DOI
  10.1111/cas.16149
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08894, KAKENHI-PROJECT-22K09006, KAKENHI-PROJECT-21K07179, KAKENHI-PROJECT-23K24164
[Journal Article] Paneth-like cells produced from OLFM4+ stem cells support OLFM4+ stem cell growth in advanced colorectal cancer2024
- Author(s)
  Sakahara Mizuho、Okamoto Takuya、Srivastava Upasna、Natsume Yasuko、Yamanaka Hitomi、Suzuki Yutaka、Obama Kazutaka、Nagayama Satoshi、Yao Ryoji
- Journal Title
  
  Communications Biology
  
  Volume: 7 Issue: 1 Pages: 27-27
- DOI
  10.1038/s42003-023-05504-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19468, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-21H02770
[Journal Article] Spatial and single-cell transcriptomics decipher the cellular environment containing HLA-G+ cancer cells and SPP1+ macrophages in colorectal cancer2023
- Author(s)
  Ozato Y, Mimori K(28番目）,他26名
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 1 Pages: 111929-111929
- DOI
  10.1016/j.celrep.2022.111929
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08908, KAKENHI-PROJECT-22K19464, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-20H04281, KAKENHI-PROJECT-19K07659, KAKENHI-PROJECT-20K21832, KAKENHI-PUBLICLY-22H04839, KAKENHI-PROJECT-23K24164, KAKENHI-PROJECT-22K08894, KAKENHI-PROJECT-22K09006, KAKENHI-PROJECT-23K06662, KAKENHI-PROJECT-23K08128, KAKENHI-PROJECT-21K07179
[Journal Article] Subclonal accumulation of immune escape mechanisms in microsatellite instability-high colorectal cancers2023
- Author(s)
  Kobayashi Y, Niida A, Nagayama S, Saeki K, （中略）, Mizuno S, Kawazu M, Kohsaka S, Ueno T, Mano H, Ishihara S, Uemura M, Mori M, Doki Y, Eguchi H, Oshima M, Suzuki Y, Shibata T, Mimori K.
- Journal Title
  
  Br J Cancer
  
  Volume: 129 Issue: 7 Pages: 1105-1118
- DOI
  10.1038/s41416-023-02395-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07153, KAKENHI-PROJECT-21K12117, KAKENHI-PROJECT-22K08894, KAKENHI-PROJECT-22K09006, KAKENHI-PROJECT-23K06662, KAKENHI-PROJECT-23K08128, KAKENHI-PROJECT-21K07179, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-21H02795, KAKENHI-PROJECT-23K24164
[Journal Article] Mutated genes on ctDNA detecting postoperative recurrence presented reduced neoantigens in primary tumors in colorectal cancer cases.2023
- Author(s)
  Nagayama S, Kobayashi Y, Fukunaga M, Sakimura S, Sugimachi K, Sasaki S, Masuda T, Mafune KI, Oshima M, Shibata T, Suzuki Y, Mimori
- Journal Title
  
  Sci Rep
  
  Volume: 13(1) Issue: 1 Pages: 1366-1366
- DOI
  10.1038/s41598-023-28575-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07179, KAKENHI-PROJECT-22K09006, KAKENHI-PROJECT-23K24164
[Journal Article] Differential ion mobility mass spectrometry in immunopeptidomics identifies neoantigens carrying colorectal cancer driver mutations2022
- Author(s)
  Yuriko Minegishi, Kazuma Kiyotani, Kensaku Nemoto, Yoshikage Inoue, Yoshimi Haga, Risa Fujii, Naomi Saichi, Satoshi Nagayama, Koji Ueda
- Journal Title
  
  Communications Biology
  
  Volume: 5 Issue: 1 Pages: 831-831
- DOI
  10.1038/s42003-022-03807-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K05759, KAKENHI-PROJECT-23K21392
[Journal Article] Integration of human inspection and artificial intelligence‐based morphological typing of patient‐derived organoids reveals interpatient heterogeneity of colorectal cancer2022
- Author(s)
  Okamoto Takuya、Natsume Yasuko、Doi Motomichi、Nosato Hirokazu、Iwaki Toshiyuki、Yamanaka Hitomi、Yamamoto Mayuko、Kawachi Hiroshi、Noda Tetsuo、Nagayama Satoshi、Sakanashi Hidenori、Yao Ryoji
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 8 Pages: 2693-2703
- DOI
  10.1111/cas.15396
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19468, KAKENHI-PROJECT-21H02770
[Journal Article] Comparative Analysis of Patient-Matched PDOs Revealed a Reduction in OLFM4-Associated Clusters in Metastatic Lesions in Colorectal Cancer2021
- Author(s)
  Okamoto Takuya、duVerle David、Yaginuma Katsuyuki、Natsume Yasuko、Yamanaka Hitomi、Kusama Daisuke、Fukuda Mayuko、Yamamoto Mayuko、Perraudeau Fanny、Srivastava Upasna、Kashima Yukie、Suzuki Ayako、Kuze Yuuta、Takahashi Yu、Ueno Masashi、Sakai Yoshiharu、Noda Tetsuo、Tsuda Koji、Suzuki Yutaka,Nagayama Satoshi,Yao Ryoji
- Journal Title
  
  Stem Cell Reports
  
  Volume: 16 Issue: 4 Pages: 954-967
- DOI
  10.1016/j.stemcr.2021.02.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06333, KAKENHI-PROJECT-18H02684, KAKENHI-PROJECT-18K07217, KAKENHI-PROJECT-19K22570, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-21H02770
[Journal Article] Evaluation of the RAS signaling network in response to MEK inhibition using organoids derived from a familial adenomatous polyposis patient2020
- Author(s)
  Osumi Hiroki、Muroi Atsushi、Sakahara Mizuho、Kawachi Hiroshi、Okamoto Takuya、Natsume Yasuko、Yamanaka Hitomi、Takano Hiroshi、Kusama Daisuke、Shinozaki Eiji、Ooki Akira、Yamaguchi Kensei、Ueno Masashi、Takeuchi Kengo、Noda Tetsuo、Nagayama Satoshi、Koshikawa Naohiko、Yao Ryoji
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 17455-17455
- DOI
  10.1038/s41598-020-74530-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06333, KAKENHI-PROJECT-18H02684, KAKENHI-PROJECT-19K22570, KAKENHI-PROJECT-16H06277, KAKENHI-PLANNED-17H06329
[Journal Article] IFN/STAT signaling controls tumorigenesis and the drug response in colorectal cancer2019
- Author(s)
  Sakahara Mizuho、Okamoto Takuya、Oyanagi Jun、Takano Hiroshi、Natsume Yasuko、Yamanaka Hitomi、Kusama Daisuke、Fusejima Mishio、Tanaka Norio、Mori Seiich、Kawachi Hiroshi、Ueno Masashi、Sakai Yoshiharu、Noda Tetsuo、Nagayama Satoshi、Yao Ryoji
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 4 Pages: 1293-1305
- DOI
  10.1111/cas.13964
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K14620, KAKENHI-PROJECT-19K22570, KAKENHI-PLANNED-17H06333, KAKENHI-PROJECT-18H02684
[Journal Article] Improved phosphoproteomic analysis for phosphosignaling and active-kinome profiling in Matrigel-embedded spheroids and patient-derived organoids2018
- Author(s)
  Abe Yuichi、Tada Asa、Isoyama Junko、Nagayama Satoshi、Yao Ryoji、Adachi Jun、Tomonaga Takeshi
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 11401-11401
- DOI
  10.1038/s41598-018-29837-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06333, KAKENHI-PROJECT-16H04707, KAKENHI-PROJECT-18H02684, KAKENHI-PROJECT-16H06150, KAKENHI-PROJECT-16K14620, KAKENHI-PROJECT-17K15014
[Journal Article] AFAP1L1, a novel associating partner with vinculin, modulates cellular morphology and motility, and promotes the progression of colorectal cancers2014
- Author(s)
  Ryo Takahashi, Satoshi Nagayama, Moritoshi Furu, Yoichiro Kajita, Tomohisa Kato, Seiya Imoto, Yoshiharu Sakai and Junya Toguchida
- Journal Title
  
  Cancer Medicine
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-23501276
[Journal Article] AFAP1L1, a novel associating partner with vinculin, modulates cellular morphology and motility, and promotes the progression of colorectal cancers.2014
- Author(s)
  Takahashi R, Nagayama S, Furu M, Kajita Y, Jin Y, Kato T, Imoto S, Sakai Y, Toguchida J.
- Journal Title
  
  Cancer Medicine
  
  Volume: なし Issue: 4 Pages: 759-774
- DOI
  10.1002/cam4.237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501276, KAKENHI-PROJECT-24390353, KAKENHI-PROJECT-25670643
[Journal Article] Activation of the non-canonical Dvl-Rac1-JNK pathway by Frizzled homologue 10 in human synovial sarcoma2009
- Author(s)
  Fukukawa C, Nagayama S, Tsunoda T, Toguchida J, Nakamura Y, Katagiri T
- Journal Title
  
  Oncogene 28
  
  Pages: 1110-1120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591589
[Journal Article] Inverse correlation of the up-regulation of FZD10 expression and the activation of beta-catenin in synchronous colorectal tumors.2009
- Author(s)
  Nagayama S, et al.
- Journal Title
  
  Cancer Sci. 100
  
  Pages: 405-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591589
[Journal Article] Inverse correlation of the up-regulation of FZD10 expression and the activation of beta-catenin in synchronous colorectal tumors.2009
- Author(s)
  Nagayama S, Yamada E, Kohno Y, Aoyama T, Fukukawa C, Kubo H, Watanabe G, Katagiri T, Nakamura Y, Sakai Y, Toguchida J
- Journal Title
  
  Cancer Sci 100
  
  Pages: 405-412
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591589
[Journal Article] Inverse correlation of the up-regulation of FZD10 expression and the activation of beta-catenin in synchronous colorectal tumors2009
- Author(s)
  Nagayama S
- Journal Title
  
  Cancer Science 100
  
  Pages: 405-412
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591589
[Journal Article] Radioimmunotherapy of human synovial sarcoma using a monoclonal antibody against FZD10.2008
- Author(s)
  Chikako Fukukawa, Hirofumi Hanaoka, Satoshi Nagayama, Tatsuhiko Tsunoda, Junya Toguchida, Keigo Endo, Yusuke Nakamura, Toyomasa Katagiri
- Journal Title
  
  Cancer Sci 99
  
  Pages: 432-440
- NAID
  10024002974
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591589
[Journal Article] The administration of naked plasmid DNA in to the liver induces antit umor innate immunity in amurine liver metastasis model.2007
- Author(s)
  Yonenaga Y, Mori A, Fujimoto A, Nagayama S, Tachibana T, Onodera H, Uemoto S
- Journal Title
  
  Journal of Gene Medicine 9
  
  Pages: 299-307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591461
[Journal Article] Tumour plasticity and extravascular circulation in ECV304 human bladder carcinoma cells.2006
- Author(s)
  Fujimoto A, Onodera H, Mori A, Nagayama S, Yonenaga Y, Tachibana
- Journal Title
  
  Anticancer Research 26
  
  Pages: 59-69
- Data Source
  KAKENHI-PROJECT-18591461
[Journal Article] Tumour plasticity and extravascular circulation in ECV304 human bladder carcinoma cells2006
- Author(s)
  Fujimoto A, Onodera H, Mori A, Nagayama S, Yonenaga Y, Tachibana T
- Journal Title
  
  Anticancer Res. 26(1A)
  
  Pages: 59-69
- Data Source
  KAKENHI-PROJECT-17790912
[Journal Article] Expression of claudin7 is tightly associated with epithelial structures in synovial sarcomas, and regulated by a member of ets family transcription factor, ELF32006
- Author(s)
  Yoshiki Kohno, Takeshi Okamoto, Tatsuya Ishibe, Satoshi Nagayama, Yasuko Shima, Kohichi Nishijo, Kohtaro R.Shibata, Koichi Fukiage, Seiji Otsuka, Daisuke Ueshima, Nobuhito Araki, Norifumi Naka, Yasuaki Nakashima, Tomoki Aoyama, Tomitaka Nakayama, Takashi Nakamura, Junya Toguchida
- Journal Title
  
  J.Biol.Chem. 281
  
  Pages: 38941-38950
- Data Source
  KAKENHI-PROJECT-17790912
[Journal Article] Therapeutic potential of antibodies against FZD10, a cell-surface protein, for synovial sarcomas2005
- Author(s)
  Nagayama, S., et al.
- Journal Title
  
  Oncogene 24(15)
  
  Pages: 6201-6212
- Data Source
  KAKENHI-PROJECT-17659114
[Journal Article] Therapeutic potential of antibodies against FZD10, a cell-surface protein, for synovial sarcomas2005
- Author(s)
  Nagayama, S., et al.
- Journal Title
  
  Oncogene 24
  
  Pages: 6201-6212
- Data Source
  KAKENHI-PROJECT-17790912
[Presentation] MSI-H大腸がんの免疫回避にむけたゲノム進化機構.2023
- Author(s)
  三森功士, 小林雄太, 新井田厚司,高橋数冴, 長山聡, 増田隆明.
- Organizer
  第82回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24164
[Presentation] 大腸癌におけるPaneth様細胞はOLFM4陽性幹細胞から派生し、同細胞の増殖を支持する2023
- Author(s)
  長山聡、坂原瑞穂、岡本拓也、鈴木穣、小濱和貴、八尾良司
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02770
[Presentation] リン酸化プロテオミクスと公共薬剤感受性データの統合解析による薬剤耐性大腸がん肝転移巣の新規創薬探索2022
- Author(s)
  軍司大悟、阿部雄一、長山聡、坂井義治、小濵和貴、朝長毅、足立淳
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03544
[Presentation] リン酸化プロテオミクスと公共薬剤感受性データの統合解析による薬剤耐性大腸がん肝転移巣の新規創薬探索2022
- Author(s)
  軍司大悟、阿部雄一、長山聡、坂井義治、小濵和貴、朝長毅、足立淳
- Organizer
  日本プロテオーム学会2022年大会
- Data Source
  KAKENHI-PROJECT-20H03544
[Presentation] リン酸化プロテオームデータと薬剤感受性データの統合解析による薬剤耐性大腸がん肝転移巣の新規治療標的探索2022
- Author(s)
  軍司大悟、阿部雄一、長山聡、坂井義治、小濵和貴、朝長毅、足立淳
- Organizer
  第42回日本分子腫瘍マーカー研究会
- Data Source
  KAKENHI-PROJECT-20H03544
[Presentation] 患者由来大腸癌オルガノイドのAIによる形態タイピングの試み2022
- Author(s)
  長山聡、岡本拓也、八尾良司
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02770
[Presentation] 患者由来大腸がんオルガノイド同所移植マウスモデルにおける転移播種細胞2021
- Author(s)
  岡本拓也、柳沼克幸、長山聡、小濱和貴、八尾良司
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02770
[Presentation] 転移に伴う細胞不均一性の変化2021
- Author(s)
  八尾良司、長山聡、岡本拓也
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02770
[Presentation] 患者由来大腸癌オルガノイドを用いた細胞分化プロセスの解析2021
- Author(s)
  長山聡、岡本拓也、八尾良司
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02770
[Presentation] ヒト大腸がん由来オルガノイド移植マウスモデルにおける転移播種がん細胞のEMT解析2021
- Author(s)
  柳沼克幸、岡本拓也、長山聡、八尾良司
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02770
[Presentation] 患者由来大腸がんオルガノイド同所移植マウスモデルにおける転移播種細胞の同定2020
- Author(s)
  岡本拓也、柳沼克幸、長山聡、八尾良司
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02684
[Presentation] 大腸癌組織を構成する細胞集団の多様性2020
- Author(s)
  長山聡、岡本拓也、八尾良司
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02684
[Presentation] ヒト大腸がんオルガノイド同所移植マウスモデルにおける転移腫瘍の発生とEMTマーカーの発現2020
- Author(s)
  柳沼克幸、岡本拓也、長山聡、八尾良司
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02684
[Presentation] 進行大腸がんオルガノイドの1細胞解析2019
- Author(s)
  八尾良司、長山聡、鈴木穰
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02684
[Presentation] 大腸がん同所移植モデルマウスを用いた転移の再現2019
- Author(s)
  岡本拓也、柳沼克幸、長山聡、八尾良司
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02684
[Presentation] Quantitative proteomic analysis of colorectal cancer liver metastases resistant to postoperative adjuvant chemothrapy.2019
- Author(s)
  軍司大悟、阿部雄一、朝長毅、長山聡、足立淳
- Organizer
  日本プロテオーム学会2019年大会第70回日本電気泳動学会総会
- Data Source
  KAKENHI-PROJECT-19H03530
[Presentation] BRAF V600E変異陽性大腸がんに有効な既存薬の発見2019
- Author(s)
  清水裕貴、きょう　博、大原智子、長山聡、藤田直也、片山量平
- Organizer
  第78回日本癌学会
- Data Source
  KAKENHI-PROJECT-18K07218
[Presentation] Development of novel EV-based biomarker for colorectal cancer and its physiological role for angiogenesis2019
- Author(s)
  Atsushi Ikeda, Satoshi Nagayama, Koji Ueda
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16KT0116
[Presentation] 大腸癌発生と薬剤感受性におけるIFN/STATシグナル伝達系の関与2019
- Author(s)
  長山聡、岡本拓也、八尾良司
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02684
[Presentation] Quantitative proteomic profiling of tissue-exudative EVs identified an early diagnostic biomarker protein for colorectal cancer2019
- Author(s)
  Makoto Konishi, Makoto Sumazaki, Satoshi Muraoka, Atsushi Ikeda, Risa Fujii, Naomi Saichi, Hideaki Shimada, Satoshi Nagayama, Koji Ueda
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16KT0116
[Presentation] Identification of a novel diagnostic antigen on circulating exosomes, toward sensitive early detection of colon cancer2018
- Author(s)
  小西惇、須磨崎真、長山聡、植田幸嗣
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16KT0116
[Presentation] Development of liquid biopsy diagnostics for colorectal cancer by proteomic profiling of cultured tissue-derived exosome2018
- Author(s)
  池田篤志、長山聡、植田幸嗣
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16KT0116
[Presentation] 大腸癌切除組織と組織培養分泌エクソソームの網羅的プロテオーム比較分析による大腸癌リキッドバイオプシー診断法開発2017
- Author(s)
  村岡賢, 大西なおみ, 池田篤志, 須磨崎真, 長山聡, 植田幸嗣
- Organizer
  日本細胞外小胞学会2017年年会
- Data Source
  KAKENHI-PROJECT-16KT0116
[Presentation] Proteome-wide profiling of viable tissue-derived extracellular vesicles for development of early diagnostic biomarkers for colorectal cancer2017
- Author(s)
  Muraoka, S., Nagayama, S., and Ueda, K.
- Organizer
  The International Society For Extracellular Vesicles 6th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0116
[Presentation] Targeted proteomic analysis for biomarker discovery of colorectal cancer metastasis from plasma EVs.2016
- Author(s)
  Takashi Shiromizu, Mimiko Ishida, Naomi Ohnishi, Risa Fujii, Koji Ueda, Satoshi Nagayama and Takeshi Tomonaga.
- Organizer
  5th Annual Meeting of the International Society for Extracellular Vesicles
- Place of Presentation
  ロッテルダム
- Year and Date
  2016-05-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06865
[Presentation] 大腸がん同一症例の原発/転移組織の定量プロテオミクス解析による転移マーカー探索および血中エクソソームマーカーへの応用2015
- Author(s)
  白水崇、長山聡、朝長毅
- Organizer
  第35回日本分子腫瘍マーカー研究会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-07
- Data Source
  KAKENHI-PROJECT-15K06865
[Presentation] Proteomic analysis for biomarker discovery in metastatic colorectal cancer tissues and plasma exosomes.2015
- Author(s)
  Takashi Shiromizu, Satoshi Nagayama, Takeshi Tomonaga
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K06865
[Presentation] 大腸癌臨床組織膜タンパク質および血中エクソソームのプロテオーム解析による転移マーカーの探索2015
- Author(s)
  白水崇、長山聡、朝長毅
- Organizer
  第2回日本細胞外小胞学会
- Place of Presentation
  広島
- Year and Date
  2015-08-26
- Data Source
  KAKENHI-PROJECT-15K06865
[Presentation] Biomarker discovery of colorectal cancer metastasis from cancer tissues and verification in plasma exosomes by targeted proteomics.2015
- Author(s)
  Takashi Shiromizu, Satoshi Nagayama, Takeshi Tomonaga
- Organizer
  第13回日本プロテオーム学会
- Place of Presentation
  熊本
- Year and Date
  2015-07-23
- Data Source
  KAKENHI-PROJECT-15K06865
[Presentation] 細胞骨格関連タンパクC7059は細胞形態および細胞遊走を制御し、大著癌進展に関与する2014
- Author(s)
  長山聡
- Organizer
  日本外科学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23501276
[Presentation] アクチン骨格関連タンパクC7059 は細胞遊走能および浸潤仮足(invadopodia)形成を制御し,大腸癌進展に関与する2013
- Author(s)
  高橋亮、長山聡、布留守敏、梶田洋一郎、村上哲平、加藤滋、久森重夫、山田理大、大越香江、角田茂、田中英治、河田健二、小濱和貴、長谷川傑、岡部寛、戸口田淳也、坂井義治
- Organizer
  第113回日本外科学会
- Data Source
  KAKENHI-PROJECT-23501276
[Presentation] 細胞骨格関連タンパクC7059 は細胞形態,遊走能および浸潤仮足形成を制御し,大腸癌進展に関与する2013
- Author(s)
  高橋亮、長山聡、布留守敏、梶田洋一郎、大越香江、山田理大、河田健二、長谷川傑、戸口田淳也、坂井義浩
- Organizer
  第68回日本消化器外科学会
- Data Source
  KAKENHI-PROJECT-23501276
[Presentation] 細胞骨格関連タンパクC7059 は細胞遊走能を制御して大腸癌進展に関与する2013
- Author(s)
  長山聡、高橋亮、井元清哉、布留守敏、梶田洋一郎、片桐豊雅、中村祐輔、坂井義治、戸口田淳也
- Organizer
  第72回日本癌学会
- Place of Presentation
  (英語口演)
- Data Source
  KAKENHI-PROJECT-23501276
[]

1. TOMONAGA Takeshi (80227644)

# of Collaborated Projects: 6 results

# of Collaborated Products: 9 results
2. ADACHI JUN (20437255)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
3. 新井田厚司 (00772493)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
4. 三森功士 (50322748)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
5. TOGUCHIDA Junya (40273502)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. YAO Ryoji (80291095)

# of Collaborated Projects: 3 results

# of Collaborated Products: 18 results
7. 片山量平 (60435542)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
8. MORI Akira (60324646)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
9. SAKAI Yoshiharu (60273455)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
10. Ueda Koji (10509110)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
11. KUBO Hajime (50362520)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. ONODERA Hisashi (50240825)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TSURUYAMA Tatsuaki (00303842)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Shiromizu Takashi (00582678)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
15. ISHIHAMA Yasushi (30439244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. MATSUBARA Hisahiro (20282486)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 波多野悦朗 (80359801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 小川晃平 (10359789)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 米永吉邦 (10422974)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 西尾誠人 (00281593)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 藤田直也 (20280951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 野村大成 (90089871)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 朴成和 (50505948)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 佐藤友美 (10333353)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 大津甫 (50827227)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 宇野直輝 (60624781)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 丸山玲緒 (60607985)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 斉藤秀幸 (10826233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 小嶋泰弘 (00881731)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
30. 鈴木穣 (40323646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 大村洋文 (60767375)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. LOW SIEWKEE (40634720)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. MIZUNO Shinichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. TOSHIMA Takeo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 戸田口淳也

# of Collaborated Projects: 0 results

# of Collaborated Products: 8 results
36. 峯岸ゆり子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 吉住朋晴

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAGAYAMA Satoshi 長山 聡

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Development of a novel therapy for colorectal cancers based on the gene mutation profiles.Principal Investigator

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NAGAYAMA Satoshi 長山聡