MASUHARA Masaaki 増原正明

Researcher Number	70372901
Other IDs
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Affiliation (based on the past Project Information) *help	2016: 鹿児島大学, 医歯学域歯学系, 講師 2012: 鹿児島大学, 医歯(薬)学総合研究科, 講師 2011 – 2012: 鹿児島大学, 大学院・医歯学総合研究科, 講師 2011: 明海大学, 歯学部, 助教 2010: 鹿児島大学, 医歯学総合研究科, 講師 … More 2009: Meikai University, 大学院・医歯学総合研究科, 講師 2006 – 2009: Meikai University, School of Dentistry, Division of Oral Anatomy, Department of Human, Development and Fostering, Assistant Professor, 歯学部, 助教 2004 – 2006: Meikai University, School of Dentistry, Department of Oral Anatomy, Assistant Professor, 歯学部, 助手 Less
Review Section/Research Field	Principal Investigator Morphological basic dentistry / Surgical dentistry / Functional basic dentistry Except Principal Investigator Morphological basic dentistry
Keywords	Principal Investigator 破骨細胞 / ラフト / カベオラ / 分化 / RNAi / 治療法開発 / ES/iPS / ES/iPS細胞 / ビスホスホネート / BRONJ … More / KIFファミリー / Rabファミリー / イメージング / 細胞・組織 / 薬理学 / GPR30 / 細胞極性 / シグナル伝達 / エストロゲン受容体 / ケルセチン / 極性 / コレステロール / Caveolin-1 / カベオリン-1 / 脂質ラフト / ES細胞 / yeast two-hyrid screening / 細胞内情報伝達 / リソソーム / カテプシン / NF-κB … More Except Principal Investigator RANKL / TGF-β / 破骨細胞分化 / OPG / osteoclastogenesis / 骨吸収 / 骨芽細胞 / beta ig-h3 / caveolin-1 / prostaglandin / bone resorption / osteoblasts / fluid shear stress / bone / 破骨細胞文化 / プロスタグランジン / シェアストレス / 骨 / osteopontin / integrin / RGD sequence / osteoclast progenitors / 接着タンパク / オステオポンチン / インテグリン / RGD配列 / 破骨細胞前駆細胞 / 分泌機構 / 細胞融合タンパク質 / ノックアウトマウス / scavenger receptor / LDL受容体 / 破骨細胞形成 / FcRγ / カベオリン1ノックアウトマウス / 脂質ラフト / カベオリン1 / FcRY / NFATc1 / コレステロール / raft / lipid / 破骨細胞 Less

ES/iPS細胞由来遺伝子改変破骨細胞によるBRONJ治療法の開発Principal Investigator
- Principal Investigator
  
  増原正明
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kagoshima University
Analysis ofthe cell polarity in osteoclastsPrincipal Investigator
- Principal Investigator
  
  MASUHARA Masaaki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Kagoshima University
DEPENDENCY OF OSTEOCLAST DIFFERENTIATION ON EXOGENOUS CHOLESTEROL AND ROLE OF CAVEOLIN-1 IN OSTEOCLASTOGENESIS
- Principal Investigator
  
  HAKEDA Yoshiyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
Analysis of raft/caveolae function in osteoclastsPrincipal Investigator
- Principal Investigator
  
  MASUHARA Masaaki
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
Elucidation on roles of caveolae/lipid raft on osteoclast differentiation and bone resorption and on intracellular trafficking of caveolin-1
- Principal Investigator
  
  HAKEDA Yoshiyuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
破骨細胞分化における細胞膜脂質ラフト/カベオラの機能解析Principal Investigator
- Principal Investigator
  
  増原正明
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
Investigation of action of shear stress, which is produced by Mechanical loading applied to the skeleton, on osteodast formation and bone-resorbing activity
- Principal Investigator
  
  HAKEDA Yoshiyuki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
破骨細胞分化において転写因子NF-κB等を制御する新規遺伝子の探索Principal Investigator
- Principal Investigator
  
  増原正明
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
Elucidation of role of beta ig-3 derived from osteoclasts in bone resorption and formation
- Principal Investigator
  
  HAKEDA Yoshiyuki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University

All 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] Inhibition of osteoclastogenesis by quercetin via membrane-type estrogen receptor GPR302013
- Author(s)
  Masuhara M, Sato T
- Journal Title
  
  J. Pharmacological Sci.
  
  Volume: 121 Pages: 248-248
- Data Source
  KAKENHI-PROJECT-22791792
[Journal Article] Effect of chronic stress induced by repeated oral administration on performance of several behavior tests in ovariectomized mice2012
- Author(s)
  Tsukahara T, Nagayama T, Masuhara M, Sato T
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 118 Suppl.1 Pages: 192-192
- Data Source
  KAKENHI-PROJECT-22791792
[Journal Article] Receptor activator of NF-kB ligand-dependent expression of caveolin-1 in osteoclast precursors, and high dependency of osteoclastogenesis on exogenous lipoprotein2012
- Author(s)
  Naoto Hada
- Journal Title
  
  Bone
  
  Volume: 50 Issue: 1 Pages: 226-236
- DOI
  10.1016/j.bone.2011.10.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592341, KAKENHI-PROJECT-22791792
[Journal Article] Receptor activator of NF-kB ligand-dependent expression of caveolin-1 in osteoclast precursors and high dependency of osteoclastogenesis on exogenous lipoprotein2012
- Author(s)
  Hada N, Okayasu M, Ito J, Nakayachi M, Hayashida C, Kaneda T, Uchida N, Muramatsu T, Koike C, Masuhara M, Sato T, Hakeda Y
- Journal Title
  
  Bone
  
  Volume: 50 Pages: 226-236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592341
[Journal Article] Low-density lipoprotein receptor deficiency causes impaired osteoclastogenesis and increased bone mass in mice due to a defect in osteoclasticcell-cell fusion2012
- Author(s)
  Okayasu M, Nakayachi M, Hayashida C, Ito J, Kaneda T, Masuhara M, Suda N, Sato T, Hakeda Y
- Journal Title
  
  J Biol Chem
  
  Volume: (In press) Issue: 23 Pages: 19229-19241
- DOI
  10.1074/jbc.m111.323600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592341, KAKENHI-PROJECT-22791792, KAKENHI-PROJECT-23593018, KAKENHI-PROJECT-24593079
[Journal Article] Effects of quercetin on osteoclastogenesis and involvement in membrane estrogen receptor GPR302012
- Author(s)
  Masuhara M, Sato T
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 118 Suppl.1 Pages: 164-164
- Data Source
  KAKENHI-PROJECT-22791792
[Journal Article] Effects of quercetin on osteoclastogenesis-estrogenic and non-estrogenic activity-2011
- Author(s)
  Masuhara M, Nagayama T, Sato T
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 115 Suppl.1 Pages: 269-269
- Data Source
  KAKENHI-PROJECT-22791792
[Journal Article] 破骨細胞分化におけるケルセチンの影響2011
- Author(s)
  増原正明、佐藤友昭
- Journal Title
  
  Journal of Oral Biosciences
  
  Volume: 53 Suppl Pages: 199-199
- Data Source
  KAKENHI-PROJECT-22791792
[Journal Article] サイトカインと破骨細胞分化におけるシグナル伝達2010
- Author(s)
  増原正明
- Journal Title
  
  鹿児島大学歯学部紀要 30
  
  Pages: 45-53
- NAID
  120005231978
- Data Source
  KAKENHI-PROJECT-20791342
[Journal Article] サイトカインと破骨細胞分化におけるシグナル伝達2010
- Author(s)
  増原正明
- Journal Title
  
  鹿児島大学歯学部紀要
  
  Volume: Vol. 30 Pages: 45-53
- NAID
  120005231978
- URL
  http://hdl.handle.net/10232/17031
- Data Source
  KAKENHI-PROJECT-22791792
[Journal Article] サイトカインと破骨細胞分化におけるシグナル伝達2010
- Author(s)
  増原正明
- Journal Title
  
  鹿児島大学歯学部紀要 Vol.30
  
  Pages: 45-53
- NAID
  120005231978
- Data Source
  KAKENHI-PROJECT-20791342
[Journal Article] Protective protein/cathepsin A downregulates osteo clastogenesis by associating with and degrading NFKB p50/p652009
- Author(s)
  Masuhara M, Sato T, Had a N, Hakeda Y
- Journal Title
  
  J. Bone Miner. Metab. 27(1)
  
  Pages: 46-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791342
[Journal Article] IFN-ζ/limitin inhibits generation of osteoclast precursors.2009
- Author(s)
  Sato, T., Masuhara, M., Hada, N., Okayasu, M., Hakeda, Y.
- Journal Title
  
  J. Meikai Dent. Med. 38
  
  Pages: 1-8
- NAID
  40016525912
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592130
[Journal Article] Protective protein/cathepsin A down-regulates osteoclastogenesis by associating with and degrading NF-kB p50/p65.2009
- Author(s)
  Masuhara, M.,Sato, T. Hada, N., Hakeda, Y.
- Journal Title
  
  J. Bone Miner. Metab. 27
  
  Pages: 46-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592130
[Journal Article] Protective protein/cathepsin A down-regulates osteoclastogenesis by associating with and degrading NF-κB p50/p65.2009
- Author(s)
  Masuhara M, Sato T, Hada N, Hakeda Y
- Journal Title
  
  J. Bone Miner. Metab. 27(1)
  
  Pages: 46-56
- NAID
  10025336150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791342
[Journal Article] IFN-ζ/limitin inhibits generation of osteoclast precursors.2009
- Author(s)
  Sato T, Masuhara M, Hada N, Okayasu M, Hakeda Y
- Journal Title
  
  J. Meikai Dent. Med 38(1)
  
  Pages: 1-8
- NAID
  40016525912
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791342
[Journal Article] IFN-ζ/limitin inhibits generation of osteoclast precursors.2009
- Author(s)
  Sato T, Masuhara M, Hada N, Okayasu M, Hakeda Y
- Journal Title
  
  J.Meikai Dent.Med. 38
  
  Pages: 1-8
- NAID
  40016525912
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791342
[Journal Article] PGC7/Stella protects against DNA demethylation in early embryogenesis.2007
- Author(s)
  Nakamura, T., Arai, Y., Umehara, H., Masuhara, M., Kimura, T., Taniguchi, H., Sekimoto, T., Ikawa, M., Yoneda, Y., Okabe, M., Tanaka, S., Shiota, K., Nakano, T.
- Journal Title
  
  Nature Cell Biol 9
  
  Pages: 64-71
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591922
[Journal Article] Production of IL-7 is increased in ovariectomized mice, but not RANKL mRNA expression by osteoblasts/stromal cells in bone, and IL-7 enhances generation of osteoclast precursors in vitro.2007
- Author(s)
  Sato, T., Watanabe, K., Masuhara, M., Hada, N., Hakeda, Y.
- Journal Title
  
  J. Bone Miner. Metab. 25
  
  Pages: 19-27
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591922
[Journal Article] PGC7/Stella protects against DNA demethylation in early embryogenesis.2007
- Author(s)
  Nakamura, T., Arai, Y., Umehara, H., Masuhara, M., Kimura, T., Taniguchi, H., Sekimoto, T., Ikawa, M., Yoneda, Y., Okabe, M., Tanaka, S., Shiota, K., Nakano, T.
- Journal Title
  
  Nature Cell Biol. 9
  
  Pages: 64-71
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591922
[Presentation] ケルセチンの膜型エストロゲン受容体 GPR30を介する破骨細胞分化抑制機構の解析2013
- Author(s)
  増原正明、佐藤友昭
- Organizer
  日本薬理学会
- Place of Presentation
  福岡
- Year and Date
  2013-03-23
- Data Source
  KAKENHI-PROJECT-22791792
[Presentation] 反復ストレスと卵巣摘出によるGABA神経機構の機能異常を介したマウスの情動行動変化2013
- Author(s)
  塚原飛央、増原正明、薗村貴弘、植村正憲、佐藤友昭
- Organizer
  日本薬理学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22791792
[Presentation] 反復ストレスと卵巣摘出による GABA 神経機構の機能異常を介したマウスの情動行動変化2013
- Author(s)
  塚原飛央、増原正明、薗村貴弘、植村正憲、佐藤友昭
- Organizer
  日本薬理学会
- Place of Presentation
  福岡
- Year and Date
  2013-03-23
- Data Source
  KAKENHI-PROJECT-22791792
[Presentation] ケルセチンの膜型エストロゲン受容体GPR30を介する破骨細胞分化抑制機構の解析2013
- Author(s)
  増原正明、佐藤友昭
- Organizer
  日本薬理学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22791792
[Presentation] 繰り返し強制経口投与による慢性ストレスが卵巣摘出マウスの各種行動実験の成績に及ぼす影響の検討2012
- Author(s)
  塚原飛央、永山知宏、増原正明、佐藤友昭
- Organizer
  日本薬理学会
- Place of Presentation
  京都
- Year and Date
  2012-03-15
- Data Source
  KAKENHI-PROJECT-22791792
[Presentation] ストレスが閉経マウスモデルの情動およびGABA機能に与える影響2012
- Author(s)
  塚原飛央、増原正明、薗村貴弘、永山知宏、植村正憲、佐藤友昭
- Organizer
  歯科基礎医学会
- Place of Presentation
  福島
- Data Source
  KAKENHI-PROJECT-22791792
[Presentation] ストレスが閉経マウスモデルの情動およびGABA 機能に与える影響2012
- Author(s)
  塚原飛央、増原正明、薗村貴弘、永山知宏、植村正憲、佐藤友昭
- Organizer
  歯科基礎医学会
- Place of Presentation
  福島
- Year and Date
  2012-09-15
- Data Source
  KAKENHI-PROJECT-22791792
[Presentation] ケルセチンは膜型エストロゲン受容体 GPR30 を介して破骨細胞の分化を抑制する2012
- Author(s)
  増原正明、塚原飛央、佐藤友昭
- Organizer
  日本薬理学会西南部会
- Place of Presentation
  熊本
- Year and Date
  2012-11-23
- Data Source
  KAKENHI-PROJECT-22791792
[Presentation] ケルセチンによる破骨細胞分化抑制および膜型エストロゲン受容体の関与2012
- Author(s)
  増原正明、佐藤友昭
- Organizer
  日本薬理学会
- Place of Presentation
  京都
- Year and Date
  2012-03-14
- Data Source
  KAKENHI-PROJECT-22791792
[Presentation] 繰り返し強制経口投与による慢性ストレスが卵巣摘出マウスの各種行動実験の成績に及ぼす影響の検討2012
- Author(s)
  塚原飛央、永山知宏、増原正明、佐藤友昭
- Organizer
  日本薬理学会
- Place of Presentation
  (国立京都国際会館)京都府
- Year and Date
  2012-03-15
- Data Source
  KAKENHI-PROJECT-22791792
[Presentation] ケルセチンによる破骨細胞分化抑制および膜型エストロゲン受容体の関与2012
- Author(s)
  増原正明、佐藤友昭
- Organizer
  日本薬理学会
- Place of Presentation
  (国立京都国際会館)京都府
- Year and Date
  2012-03-14
- Data Source
  KAKENHI-PROJECT-22791792
[Presentation] 破骨細胞分化におけるケルセチンの影響2011
- Author(s)
  増原正明、佐藤友昭
- Organizer
  歯科基礎医学会
- Place of Presentation
  (長良川国際会議場)岐阜県
- Year and Date
  2011-10-02
- Data Source
  KAKENHI-PROJECT-22791792
[Presentation] 破骨細胞分化におけるケルセチンの影響2011
- Author(s)
  増原正明、佐藤友昭
- Organizer
  歯科基礎医学会
- Place of Presentation
  岐阜
- Year and Date
  2011-10-02
- Data Source
  KAKENHI-PROJECT-22791792
[Presentation] 破骨細胞分化におけるケルセチンの影響-エストロゲン様作用と非エストロゲン様作用-2011
- Author(s)
  増原正明、永山知宏、佐藤友昭
- Organizer
  日本薬理学会
- Place of Presentation
  横浜
- Year and Date
  2011-03-24
- Data Source
  KAKENHI-PROJECT-22791792
[Presentation] りんごの果実と果皮の慢性的経口投与は卵巣摘出マウスの認知と情動に影響を及ぼす2010
- Author(s)
  塚原飛央、永山知宏、増原正明、佐藤友昭
- Organizer
  日本薬理学会
- Place of Presentation
  大阪
- Year and Date
  2010-03-18
- Data Source
  KAKENHI-PROJECT-20791342
[Presentation] ビタミンB12はマウス破骨細胞形成の必須因子である2008
- Author(s)
  真野博、清水純、増原正明、羽毛田慈之、河田哲典、和田政裕
- Organizer
  日本ビタミン学会
- Place of Presentation
  仙台
- Year and Date
  2008-06-14
- Data Source
  KAKENHI-PROJECT-20791342
[Presentation] 破骨細胞におけるカベオリン-1の機能解析2008
- Author(s)
  増原正明
- Organizer
  明海歯科医学会
- Place of Presentation
  埼玉
- Year and Date
  2008-06-05
- Data Source
  KAKENHI-PROJECT-20791342
[Presentation] 破骨細胞前駆細胞においてI型インターフェロンにより発現調節されるmicroRNAの網羅的解析2008
- Author(s)
  佐藤卓也、増原正明、羽田直人、岡安麻里、羽毛田慈之
- Organizer
  歯科基礎医学会
- Place of Presentation
  東京
- Year and Date
  2008-09-25
- Data Source
  KAKENHI-PROJECT-20791342
[Presentation] 破骨細胞分化におけるRANKLに依存して発現するcaveolin-1とlipid/raftの役割2008
- Author(s)
  増原正明、佐藤卓也、岡安麻里、羽田直人、金田利夫、羽毛田慈之
- Organizer
  日本骨代謝学会
- Place of Presentation
  大阪
- Year and Date
  2008-10-30
- Data Source
  KAKENHI-PROJECT-20791342
[Presentation] 破骨細胞前駆細胞において1型インターフェロンにより発現調節されるmicroRNAの網羅的解析2008
- Author(s)
  佐藤卓也、増原正明、羽田直人、岡安麻里、羽毛田慈之
- Organizer
  歯科基礎医学会
- Place of Presentation
  東京
- Year and Date
  2008-09-25
- Data Source
  KAKENHI-PROJECT-20791342
[Presentation] 破骨細胞分化に対するLipid/raftの役割2007
- Author(s)
  羽田直人、増原正明、佐藤卓也、羽毛田慈之
- Organizer
  歯科基礎医学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-18791355
[Presentation] ケルセチンは膜型エストロゲン受容体 GPR30 を介して破骨細胞の分化を抑制する
- Author(s)
  増原正明、塚原飛央、佐藤友昭
- Organizer
  薬理学会西南部会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-22791792

1. HAKEDA Yoshiyuki (90164772)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
2. SATO Takuya (00316689)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
3. KANEDA Toshio (70339521)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 佐藤友昭 (10284887)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 三井薫 (40324975)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 小戝健一郎 (90258418)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 上川善昭 (30332901)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

MASUHARA Masaaki 増原 正明

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ES/iPS細胞由来遺伝子改変破骨細胞によるBRONJ治療法の開発Principal Investigator

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Analysis ofthe cell polarity in osteoclastsPrincipal Investigator

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DEPENDENCY OF OSTEOCLAST DIFFERENTIATION ON EXOGENOUS CHOLESTEROL AND ROLE OF CAVEOLIN-1 IN OSTEOCLASTOGENESIS

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Analysis of raft/caveolae function in osteoclastsPrincipal Investigator

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Elucidation on roles of caveolae/lipid raft on osteoclast differentiation and bone resorption and on intracellular trafficking of caveolin-1

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破骨細胞分化における細胞膜脂質ラフト/カベオラの機能解析Principal Investigator

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Investigation of action of shear stress, which is produced by Mechanical loading applied to the skeleton, on osteodast formation and bone-resorbing activity

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破骨細胞分化において転写因子NF-κB等を制御する新規遺伝子の探索Principal Investigator

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Elucidation of role of beta ig-3 derived from osteoclasts in bone resorption and formation

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[Journal Article] Inhibition of osteoclastogenesis by quercetin via membrane-type estrogen receptor GPR302013

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[Journal Article] Effect of chronic stress induced by repeated oral administration on performance of several behavior tests in ovariectomized mice2012

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[Journal Article] Receptor activator of NF-kB ligand-dependent expression of caveolin-1 in osteoclast precursors, and high dependency of osteoclastogenesis on exogenous lipoprotein2012

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[Journal Article] Receptor activator of NF-kB ligand-dependent expression of caveolin-1 in osteoclast precursors and high dependency of osteoclastogenesis on exogenous lipoprotein2012

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[Journal Article] Low-density lipoprotein receptor deficiency causes impaired osteoclastogenesis and increased bone mass in mice due to a defect in osteoclasticcell-cell fusion2012

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MASUHARA Masaaki 増原正明