Kobayashi Hiroyuki 小林浩之

… Alternative Names

Researcher Number	70374478
Other IDs
Affiliation (Current)	2019: 北海道大学, 医学研究院, 客員研究員
Affiliation (based on the past Project Information) *help	2019: 北海道大学, 医学研究院, 客員研究員 2014 – 2015: 北海道大学, 大学病院, 講師 2014: 北海道大学, 大学院医学研究科, 講師 2011: 北海道大学, 大学病院, 助教 2010 – 2011: 北海道大学, 北海道大学病院, 助教 … More
Review Section/Research Field	Principal Investigator Neurosurgery / Cerebral neurosurgery Except Principal Investigator Cerebral neurosurgery / Basic Section 56010:Neurosurgery-related / Human pathology
Keywords	Principal Investigator Spinal cord injury / Transplantation / Differentiation / Migration / 神経膠腫 / 音響力学療法 / ポルフィリン誘導体 / アミノレブリン酸 / PET / 超音波 … More Except Principal Investigator Transplantation / Bone marrow stromal cell / Spinal cord injury / Differentiation / Cerebral infarction / Regenerative medicine / Functional restoration / Diffuse axonal injury / 骨髄間質細胞 / 脊髄損傷 / Diffuse brain injury / Cognitive function / DNA microarray / 脳梗塞 / Migration / Biomaterial / Neuroprotection / transplantation / 神経再生 / 脳損傷 / 再生医療 / Cerebral stroke / differentiation / brain tumor / bone marrow stromal cell / cell fusion / anti-angiogenesis / biomaterial / Diffuse axonal iniury / Spinal cord in jury / 中枢神経再生医療 / 幹細胞移植 / サイトカイン / バイオマテリアル / 光イメージング / PET / 移植 / 脳挫傷 / 分化 / 機能回復 / 中枢神経再生 / バイオイメージング / 中枢神経 / 悪性リンパ腫 / 中枢神経原発悪性リンパ腫 / 治療効果予測 / Regeneration / bone marrow / stromal cell / central nervous system / cerebral infarct / spinal cord injury / Bone marrow stromal cells / differenciation / 骨髄間葉系細胞 / 抗血管新生因子 / photodynamic diagnosis / lower-grade glioma / neurofibromatosis type 2 / iPS細胞 / NF2 / 疾患特異的iPS細胞 / 神経鞘腫 Less

低悪性度神経膠腫に対する蛍光診断：ポルフィリン代謝分子に対する機能解析Ongoing
- Principal Investigator
  
  山口秀
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Hokkaido University
疾患特異的iPS細胞を用いた神経線維腫症2型の病態解析と新規治療法の探索Ongoing
- Principal Investigator
  
  寺坂俊介
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Hokkaido University
Development of ALA-PET guided sonodynamic therapy for malignant gliomasPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI HIROYUKI
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurosurgery
- Research Institution
  Hokkaido University
Identification of biological characterization and predictive factors for therapeutic effect in primary diffuse large B-cell lymphoma of the central nervous system
- Principal Investigator
  
  KANAKO Hatanaka
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  Hokkaido University
Comprehensive strategy for neuronal regenerative medicine with human bone marrow stromal cells (BMSC) transplantation
- Principal Investigator
  
  KURODA Satoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Hokkaido University
Human bone marrow stromal cells transplantation to regenerate central nervous system ; The translational research with novel technologies.
- Principal Investigator
  
  SHICHINOHE Hideo
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Hokkaido University
Translational Research for Clinical Application of Autologous Bone Marrow Stromal Cell Transplantation for CNS disorders
- Principal Investigator
  
  IWASAKI Yoshinobu
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Hokkaido University
Recovery of Neurological Function after Traumatic Brain/Spinal CordInjury with Autologous Bone Marrow Stromal Cells
- Principal Investigator
  
  KURODA Satoshi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Hokkaido University
ハイリスク群における脳卒中予防を目的とした血管再生療法の開発
- Principal Investigator
  
  黒田敏
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Hokkaido University
COMPREHENSIVE RESEARCH PROJECT FOR CENTRAL NERVOUS SYSTEM REGENERATION BY BONE MARROW STROMAL CELL TRANSPLANTATION
- Principal Investigator
  
  HIDA Kazutoshi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Hokkaido University
RESEARCH FOR BONE MARROW STROMAL CELLS (BMSC) TRANSPLANTATION THERAPY FOR INJURED CENTRAL NERVOUS SYSTEM FOCUSED ON AXON EXTENSION FROM THE HOST NEURONSPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI H., 七戸秀夫
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  HOKKAIDO UNIVERSITY
A basic study of gene and anti-angiogenic therapy for malignant brain tumor using bone marrow stromal cell and its potential of cell-fusion
- Principal Investigator
  
  IWASAKI Yoshinobu, 石井伸明
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Hokkaido University
RESEARCH FOR BONE MARROW STROMAL CELLS (BMSC) TRANSPLANTATION THERAPY FOR INJURED CENTRAL NERVOUS SYSTEM USING BIOMATERIALS AND GENE ANALYSIS
- Principal Investigator
  
  IWASAKI Yoshinobu
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  HOKKAIDO UNIVERSITY

All 2015 2014 2009 2008 2006 2005 Other

All Journal Article Presentation

[Journal Article] Porphyrin derivatives-mediated sonodynamic therapy for malignant gliomas in vitro.2015
- Author(s)
  Endo S, Kudo N, Yamaguchi S, Sumiyoshi K, Motegi H, Kobayashi H, Terasaka S, Houkin K
- Journal Title
  
  Ultrasound in Medicine & Biology
  
  Volume: 41(9) Pages: 2458-65
- DOI
  10.1016/j.ultrasmedbio.2015.05.007
- NAID
  120005828507
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26670632
[Journal Article] Bone marrow stromal cells differentiate into neurons and promote axon elongation in spinal cord slice cultures : Their role in cell transplantation therapy for spinal cord injury2008
- Author(s)
  Shichinohe H, Kuroda S, Tsuji S, Yamaguchi S, Yano S, Lee JB, Kobayashi H, Hokari M, Hida K, Kikuchi S, Iwasaki Y
- Journal Title
  
  Neurorehabil Neural Repair 22
  
  Pages: 447-457
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390387
[Journal Article] Bone marrow stromal cells promote neurite extension in organotypic spinal cord slice : significance for cell transplantation therapy2008
- Author(s)
  Shichinohe H, Kuroda S, Tsuji S, Yamaguchi S, Yano S, Lee JB, Kobayashi H, Kikuchi S, Hida K, Iwasaki Y
- Journal Title
  
  Neurorehabil Neural Repair 22
  
  Pages: 447-57
- Data Source
  KAKENHI-PROJECT-20390377
[Journal Article] Bone marrow stromal cells differentiate into neurons and promote axon elongation in spinal cord slice cultures: Their role in cell transplantation therapy for spinal cord injury2008
- Author(s)
  Shichinohe H, Kuroda S, Tsuji S, Yamaguchi S, Yano S, Lee JB, Kobayashi H, Hokari M, Hida K, Kikuchi S, Iwasaki Y
- Journal Title
  
  Neurorehabil Neural Repair 22
  
  Pages: 447-457
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390371
[Journal Article] Temozolomide in the treatment of recurrent malignant glioma2006
- Author(s)
  Kobayashi H, Iwasaki Y., et al.
- Journal Title
  
  No Shinkei Geka 34(12)
  
  Pages: 1241-1247
- Data Source
  KAKENHI-PROJECT-16390401
[Journal Article] The effects of neuronal induction on gene expression profile in bone marrow stromal cells (BMSC)-a preliminary study using microarray analysis.2006
- Author(s)
  Yamaguchi S, Kuroda S, Kobayashi H, Shichinohe H, Yano S, Hida K, Shinpo K, Kikuchi S, Iwasaki Y
- Journal Title
  
  Brain Res. 1087(1)(Epub)
  
  Pages: 15-27
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390401
[Journal Article] Cystic meningioangiomatosis2006
- Author(s)
  Kobayashi H, Ishii N et al.
- Journal Title
  
  Pediatric Neurosurgery (印刷中)
- Data Source
  KAKENHI-PROJECT-16390401
[Journal Article] The effects of neuronal induction on gene expression profile in bone marrow stromal cells (BMSC)--a preliminary study using microarray analysis.2006
- Author(s)
  Yamaguchi S, Kuroda S, Kobayashi H, Iwasaki Y., et al.
- Journal Title
  
  Brain Res 1087(1)
  
  Pages: 15-27
- Data Source
  KAKENHI-PROJECT-16390401
[Journal Article] Cystic meningioangiomatosis2006
- Author(s)
  Kobayashi H, Ishii N, et al.
- Journal Title
  
  Pediatric Neurosurgery 42(5)
  
  Pages: 320-324
- Data Source
  KAKENHI-PROJECT-16390401
[Journal Article] Temozolomide in the treatment o recurrent malignant glioma.2006
- Author(s)
  Kobayashi H, Sawamura Y, Ishii N, Murata J Iwasaki Y
- Journal Title
  
  No Shinkei Geka. 34(12)
  
  Pages: 1241-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390401
[Journal Article] The effects of neuronal induction on gene expression profile in bone marrow stromal cells (BMSC)-a preliminary study using microarray analysis.2006
- Author(s)
  Yamaguchi S, Kuroda S, Kobayashi H, Iwasaki Y. et al.
- Journal Title
  
  Brain Res 1087(1)
  
  Pages: 15-27
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390401
[Journal Article] The effects of neuronal induction on gene expression profile in bone marrow stromal cells (BMSC) - a preliminary study using microarray analysis2006
- Author(s)
  Yamaguchi S, Kuroda S, Kobayashi H, Shichinohe H, Yano S, Hida K, Shinpo K, Kikuchi S, Iwasaki Y
- Journal Title
  
  Brain Res 1087
  
  Pages: 15-27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390387
[Journal Article] Temozolomide in the treatment of recurrent malignant glioma.2006
- Author(s)
  Kobayashi H, Sawamura Y, Ishii N, Murata J, Iwasaki Y
- Journal Title
  
  No Shinkei Geka. 34(12)
  
  Pages: 1241-1247
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390401
[Journal Article] Occipitoparietal benign osteoblastoma : should entire lesion be resected when magnetic resonance images reveal wide abnormal signal intensity in surrounding bone marrow?2005
- Author(s)
  Narita T, Ishii N, Kobayashi H, Iwasaki Y. et al.
- Journal Title
  
  Surg Neurol 64(2)
  
  Pages: 180-183
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390401
[Journal Article] Occipitoparietal benign osteoblastoma : should entire lesion be resected when magnetic resonance images reveal wide abnormal signal intensity in surrounding bone marrow?2005
- Author(s)
  Narita T, Ishii N, Mayuzumi H, Kobayashi H, Ikeda J, Iwasaki Y
- Journal Title
  
  Surg Neurol. 64(2)
  
  Pages: 180-3
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390401
[Presentation] 悪性神経膠腫細胞株に対するポルフィリン誘導体を用いた音響力学療法2015
- Author(s)
  遠藤将吾、工藤信樹、山口秀、住吉洸城、茂木洋晃、金子貞洋、小林浩之、寺坂俊介、寳金清博
- Organizer
  日本脳神経外科学会第74回学術総会
- Place of Presentation
  ロイトン札幌、さっぽろ芸術文化の館、札幌市教育文化会館（北海道札幌市）
- Year and Date
  2015-10-15
- Data Source
  KAKENHI-PROJECT-26670632
[Presentation] 悪性神経膠腫細胞株に対するポルフィリン誘導体を用いた音響力学療法2015
- Author(s)
  遠藤将吾、工藤信樹、山口秀、住吉洸城、茂木洋晃、金子貞洋、小林浩之、寺坂俊介、寳金清博
- Organizer
  第14回日本超音波治療研究会
- Place of Presentation
  高知市文化プラザかるぽーと（高知県高知市）
- Year and Date
  2015-11-28
- Data Source
  KAKENHI-PROJECT-26670632
[Presentation] 悪性神経膠腫細胞株に対するポルフィリン誘導体を用いた音響力学療法2015
- Author(s)
  遠藤将吾、工藤信樹、山口秀、住吉洸城、茂木洋晃、金子貞洋、小林浩之、寺坂俊介、寳金清博
- Organizer
  第34回日本脳神経超音波学会総会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-26670632
[Presentation] 悪性神経膠腫細胞株に対するポルフィリン誘導体を用いた音響力学療法2015
- Author(s)
  遠藤将吾、工藤信樹、山口秀、住吉洸城、茂木洋晃、金子貞洋、小林浩之、寺坂俊介、寳金清博
- Organizer
  第2回アコースティックイメージング研究会
- Place of Presentation
  北海道大学（北海道札幌市）
- Year and Date
  2015-08-07
- Data Source
  KAKENHI-PROJECT-26670632
[Presentation] 中枢神経系原発びまん性大細胞型B細胞性リンパ腫におけるDNAメチレーションの意義に関する検討2014
- Author(s)
  畑中　佳奈子，畑中　豊，藤井　恭子，小林　浩之，菅野　宏美，西原　広史，田中　伸哉，三橋　智子，松野　吉宏
- Organizer
  第32回日本脳腫瘍病理学会
- Place of Presentation
  あわぎんホール（徳島市）
- Data Source
  KAKENHI-PROJECT-24790341
[Presentation] Porphyrin Derivatives Mediated Sonodynamic Therapy on Malignant Glioma Cells in Vitro2014
- Author(s)
  遠藤将吾、小林浩之、寺坂俊介
- Organizer
  2nd International ALA and porphyrin Symposium
- Place of Presentation
  東京大学医科学研究所（東京都）
- Year and Date
  2014-11-16
- Data Source
  KAKENHI-PROJECT-26670632
[Presentation] 中枢神経系原発びまん性大細胞型B細胞性リンパ腫におけるDNAメチル化に関する解析2014
- Author(s)
  畑中　佳奈子，畑中　豊，小林　浩之，菅野　宏美，西原　広史，田中　伸哉，三橋　智子，松野　吉宏
- Organizer
  第103回日本病理学会総会
- Place of Presentation
  広島国際会議場（広島市）
- Data Source
  KAKENHI-PROJECT-24790341
[Presentation] GM1アナログMCC-257はBMSCからのneurotrophin分泌を促進する2009
- Author(s)
  小林徹
- Organizer
  第34回日本脳卒中学会総会第38回日本脳卒中の外科学会
- Place of Presentation
  松江市
- Year and Date
  2009-03-22
- Data Source
  KAKENHI-PROJECT-20390377
[Presentation] 中枢神経系原発びまん性大細胞型B細胞性リンパ腫におけるDNAメチレーションの意義に関する検討
- Author(s)
  畑中佳奈子，畑中豊、藤井恭子、小林浩之、菅野宏美，西原広史，田中伸哉、三橋智子、松野吉宏
- Organizer
  第32回日本脳腫瘍病理学会学術集会
- Place of Presentation
  あわぎんホール（徳島市）
- Year and Date
  2014-05-23 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-24790341
[Presentation] Predictive value of MGMT promoter and LINE-1 methylation status in primary central nervous system diffuse large B-cell lymphoma treated with high-dose MTX and radiotherapy.
- Author(s)
  Hatanaka CK. Hatanaka Y, Fujii K, Kobayashi H, Kannno H, Nishihara H, Mitsuhashi T, Tanaka S, Matsuno Y
- Organizer
  104th United States and Canadian Academy of Pathology Annual Meeting
- Place of Presentation
  Hynes Convention Center (Boston, USA)
- Year and Date
  2015-03-21 – 2015-03-27
- Data Source
  KAKENHI-PROJECT-24790341
[Presentation] 中枢神経系原発びまん性大細胞型B細胞性リンパ腫におけるDNAメチル化に関する検討
- Author(s)
  畑中佳奈子，畑中豊、小林浩之、菅野宏美，西原広史，田中伸哉、三橋智子、松野吉宏
- Organizer
  第103回日本病理学会総会
- Place of Presentation
  広島国際会議場（広島市）
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-24790341

1. KURODA Satoshi (10301904)

# of Collaborated Projects: 9 results

# of Collaborated Products: 7 results
2. IWASAKI Yoshinobu (00113522)

# of Collaborated Projects: 9 results

# of Collaborated Products: 12 results
3. HIDA Kazutoshi (10238305)

# of Collaborated Projects: 8 results

# of Collaborated Products: 4 results
4. YANO Shunsuke (20374481)

# of Collaborated Projects: 8 results

# of Collaborated Products: 5 results
5. SHICHINOHE Hideo (80374479)

# of Collaborated Projects: 6 results

# of Collaborated Products: 2 results
6. NAKAYAMA Naoki (40421961)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. SHIGA Tohru (80374495)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. TERASAKA SHUNSUKE (10447055)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
9. 山口秀 (70399939)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 伊師雪友 (30812284)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. KANAKO Hatanaka (10399834)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
12. MATSUNO Yoshihiro (00199829)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
13. HATANAKA Yutaka (30589924)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
14. KUDO NOBUKI (30271638)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
15. TAMURA Mamoru (80089888)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KIKUCHI S. (10271660)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 池田潤 (70332468)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 石井伸明 (70312353)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
19. 吉野雅美 (70366285)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 江良択実 (00273706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 関俊隆

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kobayashi Hiroyuki 小林 浩之

小林 浩之 コバヤシ ヒロユキ

KOBAYASHI Hiroyuki 小林 浩之

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低悪性度神経膠腫に対する蛍光診断：ポルフィリン代謝分子に対する機能解析Ongoing

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疾患特異的iPS細胞を用いた神経線維腫症2型の病態解析と新規治療法の探索Ongoing

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Development of ALA-PET guided sonodynamic therapy for malignant gliomasPrincipal Investigator

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RESEARCH FOR BONE MARROW STROMAL CELLS (BMSC) TRANSPLANTATION THERAPY FOR INJURED CENTRAL NERVOUS SYSTEM FOCUSED ON AXON EXTENSION FROM THE HOST NEURONSPrincipal Investigator

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[Journal Article] Porphyrin derivatives-mediated sonodynamic therapy for malignant gliomas in vitro.2015

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Kobayashi Hiroyuki 小林浩之

小林浩之コバヤシヒロユキ

KOBAYASHI Hiroyuki 小林浩之