Kojima Toshihisa 小嶋俊久

… Alternative Names

KOJIMA Toshihisa 小嶋俊久

小嶋俊久コジマトシヒサ

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Researcher Number	70378032
Other IDs
Affiliation (Current)	2025: 独立行政法人国立病院機構(名古屋医療センター臨床研究センター), その他部局等, その他
Affiliation (based on the past Project Information) *help	2022 – 2024: 独立行政法人国立病院機構(名古屋医療センター臨床研究センター), その他部局等, その他 2019 – 2023: 名古屋大学, 医学系研究科, 准教授 2018: 名古屋大学, 医学部附属病院, 准教授 2013 – 2017: 名古屋大学, 医学部附属病院, 講師 2009: 名古屋大学, 医学部附属病院, 講師 … More 2007 – 2008: 名古屋大学, 医学部附属病院, 助教 2006: 名古屋大学, 医学部附属病院, 助手 2004: Nagoya University, University Hospital, Associate, 医学部附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / Orthopaedic surgery Except Principal Investigator Orthopaedic surgery / Basic Section 58030:Hygiene and public health-related: excluding laboratory approach / Basic Section 56020:Orthopedics-related / Orthopaedic surgery / Public health/Health science
Keywords	Principal Investigator 関節リウマチ / 変形性関節症 / 軟骨 / メカニカルストレス / 軟骨細胞 / mechanical stress / glycolysis / metabolism / chondrocyte / 代謝リプログラミング … More / 軟骨代謝 / 生物学的製剤 / 骨代謝 / 臨床 / toll like receptor / denosumab / osteoporosis / biologics / rheumatoid arthritis … More Except Principal Investigator 変形性関節症 / 関節軟骨変性 / CD44断片化 / CD44 / ヒアルロン酸 / ADAM10 / メカニカルストレス / 断片化 / 関節リウマチ / SOX9 / 通いの場 / 介護予防 / 慢性疾患 / 社会的処方 / 疫学 / 予後予測 / 基本チェックリスト / 社会参加 / 予防 / 要介護 / 高齢発症 / フレイル / 関節軟骨変性抑制 / 関節軟骨変性の抑制 / CD44の断片化 / clinical application / mesenchymal stem cells / osteoblast / bone regeneration / tissue engineering / distraction osteogenesis / 組識工学 / 臨床研究 / 骨髄幹細胞 / 骨芽細胞 / 骨形成 / 組織工学 / 脚延長 / MMP-13 / RUNX2 / 機械的刺激 / ATDC5 / TRPV4 / スタチン / QOL / 医師-患者関係 / 治療 / 疫学研究 / 質的研究 / 医師患者関係 / ヘルスコミュニケーション / 患者 / 医師 / アンケート調査 / インタビュー / フォーカスグループ / 内軟骨性骨化 / II型コラーゲン / プロテオグリカン / 軟骨細胞 / レポーター遺伝子 / 核酸医薬品 / Midkine / 遺伝子導入 / 関節炎治療 / RNA干渉 Less

Building a Frail Prevention Strategy for Successful Aging of Rheumatoid Arthritis Patients
- Principal Investigator
  
  小嶋雅代
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
- Research Institution
  Nagoya City University
  National Center for Geriatrics and Gerontology
Inhibition of cartilage destruction by controlling metabolic reprogramming - Aiming for novel rheumatoid arthritis treatment -Principal Investigator
- Principal Investigator
  
  Kojima Toshihisa
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  National Hospital Organization Nagoya Medical Center
  Nagoya University
The suppressive effect on chondrocyte dedifferentiation by preventing the fragmentation of hyaluronan receptor CD44
- Principal Investigator
  
  Takahashi Nobunori
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Aichi Medical University
  Nagoya University
Inhibition of CD44 cleavage suppresses the chondrocyte de-differentiation
- Principal Investigator
  
  Takahashi Nobunori
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nagoya University
Inhibitory effects of combination therapy of denosumab, anti-RANKL antibody, and biological DMARD on bone and cartilage destruction in patients with rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  Kojima Toshihisa
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nagoya University
Transient receptor potential vanilloid 4 (TRPV4) plays a pivotal role in chondrogenic mechanotransduction in ATDC5 cells
- Principal Investigator
  
  Naoki Ishiguro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nagoya University
Inhibition of CD44 cleavage suppresses the chondrocyte de-differentiation
- Principal Investigator
  
  Takahashi Nobunori
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nagoya University
Evidence based communication model: mixed method
- Principal Investigator
  
  KOJIMA Masayo
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Public health/Health science
- Research Institution
  Nagoya City University
軟骨細胞の代謝に対する各種薬剤の影響の検討―スクリーニングシステムの構築―
- Principal Investigator
  
  石黒直樹
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nagoya University
Midkine RNA interferance関節内投与による関節炎治療
- Principal Investigator
  
  ISHIGURO Naoki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nagoya University
The application of osteoblast-like cells and platelet rich plasma gels transplantation for accelerating the bone regeneration in the distraction osteogenesis.
- Principal Investigator
  
  ISHIGURO Naoki
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nagoya University

[Journal Article] Association between laughter, frailty, and depression in rheumatoid arthritis patients2024
- Author(s)
  Suzuki Mochihito、Kojima Toshihisa、Terabe Kenya、Ohashi Yoshifumi、Sato Ryo、Kosugiyama Hironobu、Hasegawa Junya、Ohno Yusuke、Nagai Kaoru、Ohnishi Chinami、Sugiura Hideshi、Fujita Hitomi、Nagayoshi Mako、Kojima Masayo、Asai Shuji、Imagama Shiro
- Journal Title
  
  International Journal of Rheumatic Diseases
  
  Volume: 27 Issue: 1
- DOI
  10.1111/1756-185x.15034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16714, KAKENHI-PROJECT-23K20339
[Journal Article] Differences in prevalence of self‐reported oral hypofunction between older adult patients with rheumatoid arthritis and the general older population: A cross‐sectional study using propensity score matching2024
- Author(s)
  Kudo Yoko、Takeuchi Kenji、Kusama Taro、Kojima Toshihisa、Waguri‐Nagaya Yuko、Nagayoshi Mako、Kondo Katsunori、Mizuta Kentaro、Osaka Ken、Kojima Masayo
- Journal Title
  
  Journal of Oral Rehabilitation
  
  Volume: 00 Issue: 6 Pages: 1-7
- DOI
  10.1111/joor.13658
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03861, KAKENHI-PROJECT-23K20339
[Journal Article] 「通いの場」を拠点とした地域在住高齢者の在宅フレイル予防プログラムの開発：みんなでHEPOP！2023
- Author(s)
  小嶋雅代, 上地香杜, 安岡実佳子, 渡邉良太, 木村智恵子
- Journal Title
  
  Tokai Journal of Public Health
  
  Volume: 11 Issue: 1 Pages: 58-64
- DOI
  10.24802/tpha.2023-02
- ISSN
  2187-736X, 2434-0421
- Year and Date
  2023-07-08
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K20339
[Journal Article] Longitudinal changes in physical and cognitive functions among Participants with and without Rheumatoid arthritis in community-dwelling middle-aged and older adults2023
- Author(s)
  Yasuoka M, Tange C, Nishita Y, Tomida M, Watanabe R, Shimokata H, Otsuka R, Kojima M.
- Journal Title
  
  Ann Geriatr Med Res
  
  Volume: 27(1) Issue: 1 Pages: 58-65
- DOI
  10.4235/agmr.22.0142
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K20339
[Journal Article] Validation of grip strength as a measure of frailty in rheumatoid arthritis2022
- Author(s)
  Sobue Yasumori、Suzuki Mochihito、Ohashi Yoshifumi、Koshima Hiroshi、Okui Nobuyuki、Funahashi Koji、Ishikawa Hisato、Inoue Hidenori、Kojima Masayo、Asai Shuji、Terabe Kenya、Kishimoto Kenji、Maeda Masataka、Kihira Daisuke、Imagama Shiro、Kojima Toshihisa
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 21090-21090
- DOI
  10.1038/s41598-022-21533-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16714, KAKENHI-PROJECT-19K18496, KAKENHI-PROJECT-23K20339
[Journal Article] Factors associated with frailty in rheumatoid arthritis patients with decreased renal function2022
- Author(s)
  Yoshifumi Ohashi, Nobunori Takahashi, Yasumori Sobue, Mochihito Suzuki, Kyosuke Hattori, Kenji Kishimoto, Kenya Terabe, Syuji Asai, Toshihisa Kojima, Shiro Imagama
- Journal Title
  
  Modern Rheumatology
  
  Volume: "－" Issue: 2 Pages: 323-329
- DOI
  10.1093/mr/roac018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K20339
[Journal Article] Association between community-level social capital and frailty onset among older adults: a multilevel longitudinal study from the Japan Gerontological Evaluation Study (JAGES)2022
- Author(s)
  Noguchi T, Murata C, Hayashi T, Watanabe R, Saito M, Kojima M, Kondo K, Saito T
- Journal Title
  
  Journal of Epidemiology & Community Health
  
  Volume: 76(2) Issue: 2 Pages: 182-189
- DOI
  10.1136/jech-2021-217211
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03915, KAKENHI-PROJECT-17K04306, KAKENHI-PROJECT-21K17322, KAKENHI-PROJECT-21KK0168, KAKENHI-PROJECT-23K20339
[Journal Article] Locomotive syndrome in rheumatoid arthritis patients during the COVID-19 pandemic2022
- Author(s)
  Sobue Y, Suzuki M, Ohashi Y, Koshima H, Okui N, Funahashi K, Ishikawa H, Inoue H, Kojima M, Asai S, Terabe K, Hattori K, Kishimoto K, Takahashi N, Imagama S, Kojima T
- Journal Title
  
  Nagoya Journal of Medical Science
  
  Volume: 84 Issue: 4 Pages: 799-812
- DOI
  10.18999/nagjms.84.4.799
- ISSN
  0027-7622
- URL
  https://nagoya.repo.nii.ac.jp/records/2004207
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K20339
[Journal Article] Influence of frailty on patient global assessment in rheumatoid arthritis2022
- Author(s)
  Suzuki Mochihito、Asai Shuji、Sobue Yasumori、Ohashi Yoshifumi、Koshima Hiroshi、Okui Nobuyuki、Ishikawa Hisato、Takahashi Nobunori、Terabe Kenya、Kishimoto Kenji、Hattori Kyosuke、Imagama Shiro、Kojima Toshihisa
- Journal Title
  
  Geriatr Gerontol Int
  
  Volume: 22 Issue: 5 Pages: 399-404
- DOI
  10.1111/ggi.14375
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16714, KAKENHI-PROJECT-19K18496, KAKENHI-PROJECT-23K20339
[Journal Article] Impact of social support on severity of depressive symptoms by remission status in patients with rheumatoid arthritis2021
- Author(s)
  Yasuoka Mikako、Kojima Toshihisa、Waguri-Nagaya Yuko、Saito Tami、Takahashi Nobunori、Asai Shuji、Sobue Yasumori、Nishiume Tsuyoshi、Suzuki Mochihito、Mitsui Hiroto、Kawaguchi Yohei、Kuroyanagi Gen、Kamiji Koto、Watanabe Miki、Suzuki Sadao、Kondo Katsunori、Ojima Toshiyuki、Kojima Masayo
- Journal Title
  
  Modern Rheumatology
  
  Volume: - Issue: 3 Pages: 528-533
- DOI
  10.1093/mr/roab001
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09465, KAKENHI-PROJECT-19K18471, KAKENHI-PROJECT-23K20339
[Journal Article] Relationship between locomotive syndrome and frailty in rheumatoid arthritis patients by locomotive syndrome stage2021
- Author(s)
  Sobue Yasumori、Suzuki Mochihito、Ohashi Yoshifumi、Koshima Hiroshi、Okui Nobuyuki、Funahashi Koji、Ishikawa Hisato、Asai Shuji、Terabe Kenya、Yokota Yutaka、Kishimoto Kenji、Takahashi Nobunori、Imagama Shiro、Kojima Toshihisa
- Journal Title
  
  Modern Rheumatology
  
  Volume: 32 Issue: 3 Pages: 546-553
- DOI
  10.1093/mr/roab024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03779, KAKENHI-PROJECT-23K20339
[Journal Article] 高齢関節リウマチ患者の疫学2021
- Author(s)
  小嶋雅代
- Journal Title
  
  日本臨床リウマチ学会雑誌
  
  Volume: 33 Pages: 78-84
- NAID
  130008040322
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K20339
[Journal Article] Metabolic changes in synovial cells in early inflammation: Involvement of CREB phosphorylation in the anti-inflammatory effect of 2-deoxyglucose2021
- Author(s)
  Kishimoto Kenji、Terabe Kenya、Takahashi Nobunori、Yokota Yutaka、Ohashi Yoshifumi、Hattori Kyosuke、Kihira Daisuke、Maeda Masataka、Kojima Toshihisa、Imagama Shiro
- Journal Title
  
  Archives of Biochemistry and Biophysics
  
  Volume: 708 Pages: 108962-108962
- DOI
  10.1016/j.abb.2021.108962
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03779, KAKENHI-PROJECT-19K09619, KAKENHI-PROJECT-19K09620, KAKENHI-PROJECT-20K18061
[Journal Article] Does exercise therapy improve patient-reported outcomes in rheumatoid arthritis? A systematic review and meta-analysis for the update of the 2020 JCR guidelines for the management of rheumatoid arthritis2021
- Author(s)
  Sobue Yasumori、Kojima Toshihisa、Ito Hiromu、Nishida Keiichiro、Matsushita Isao、Kaneko Yuko、Kishimoto Mitsumasa、Kohno Masataka、Sugihara Takahiko、Seto Yohei、Tanaka Eiichi、Nakayama Takeo、Hirata Shintaro、Murashima Atsuko、Morinobu Akio、Mori Masaaki、Kojima Masayo、Kawahito Yutaka、Harigai Masayoshi
- Journal Title
  
  Modern Rheumatology
  
  Volume: - Issue: 1 Pages: 1-14
- DOI
  10.1080/14397595.2021.1886653
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K20339
[Journal Article] Metabolic reprogramming in chondrocytes to promote mitochondrial respiration reduces downstream features of osteoarthritis2021
- Author(s)
  Ohashi Yoshifumi、Takahashi Nobunori、Terabe Kenya、Tsuchiya Saho、Kojima Toshihisa、Knudson Cheryl B.、Knudson Warren、Imagama Shiro
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 15131-15131
- DOI
  10.1038/s41598-021-94611-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03779, KAKENHI-PROJECT-19K09619, KAKENHI-PROJECT-19K09620, KAKENHI-PROJECT-20K18061
[Journal Article] Activation of transient receptor potential vanilloid 4 protects articular cartilage against inflammatory responses via CaMKK/AMPK/NF-κB signaling pathway2021
- Author(s)
  Hattori Kyosuke、Takahashi Nobunori、Terabe Kenya、Ohashi Yoshifumi、Kishimoto Kenji、Yokota Yutaka、Suzuki Mochihito、Kojima Toshihisa、Imagama Shiro
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 15508-15508
- DOI
  10.1038/s41598-021-94938-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03779, KAKENHI-PROJECT-19K09619, KAKENHI-PROJECT-19K09620, KAKENHI-PROJECT-19K18496
[Journal Article] Patient satisfaction with total joint replacement surgery for rheumatoid arthritis: a questionnaire survey for the 2020 update of the Japan college of rheumatology clinical practice guidelines2021
- Author(s)
  Sobue Y, Kojima M , Kojima T, Ito H, Nishida K, Matsushita I, Hirata S, Kaneko Y, Kishimoto M, Khono M, Murashima A, Morinobu A, Mori M, Nakayama T,Sugihara T, Seto Y, Tanaka E, Hasegawa M, Kawahito Y, Harigai M.
- Journal Title
  
  Modern Rheumatology
  
  Volume: - Issue: 1 Pages: 1-6
- DOI
  10.1080/14397595.2021.1892258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K20339
[Journal Article] Hyaluronan suppresses enhanced cathepsin K expression via activation of NF-κB with mechanical stress loading in a human chondrocytic HCS-2/8 cells2020
- Author(s)
  Suzuki Mochihito、Takahashi Nobunori、Sobue Yasumori、Ohashi Yoshifumi、Kishimoto Kenji、Hattori Kyosuke、Ishiguro Naoki、Kojima Toshihisa
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 216-216
- DOI
  10.1038/s41598-019-57073-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09620, KAKENHI-PROJECT-19H03779
[Journal Article] Efficacy and safety of tacrolimus in patients with rheumatoid arthritis ? A systematic review and meta-analysis2020
- Author(s)
  Kaneko Yuko、Kawahito Yutaka、Kojima Masayo、Nakayama Takeo、Hirata Shintaro、Kishimoto Mitsumasa、Endo Hirahito、Seto Yohei、Ito Hiromu、Nishida Keiichiro、Matsushita Isao、Kojima Toshihisa、Kamatani Naoyuki、Tsutani Kiichiro、Igarashi Ataru、Hasegawa Mieko、Miyasaka Nobuyuki、Yamanaka Hisashi
- Journal Title
  
  Modern Rheumatology
  
  Volume: - Issue: 1 Pages: 1-9
- DOI
  10.1080/14397595.2020.1719607
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460608, KAKENHI-PROJECT-18H04076, KAKENHI-PROJECT-23K20339
[Journal Article] Depression, physical function, and disease activity associated with frailty in patients with rheumatoid arthritis2020
- Author(s)
  Kojima Masayo、Kojima Toshihisa、Waguri-Nagaya Yuko、Takahashi Nobunori、Asai Shuji、Sobue Yasumori、Nishiume Tsuyoshi、Suzuki Mochihito、Mitsui Hiroto、Kawaguchi Yohei、Kuroyanagi Gen、Yasuoka Mikako、Watanabe Miki、Suzuki Sadao、Arai Hidenori
- Journal Title
  
  Modern Rheumatology
  
  Volume: 2 Issue: 5 Pages: 1-8
- DOI
  10.1080/14397595.2020.1838402
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09114, KAKENHI-PROJECT-19K18471, KAKENHI-PROJECT-23K20339
[Journal Article] Inhibition of CD44 intracellular domain production suppresses bovine articular chondrocyte de-differentiation induced by excessive mechanical stress loading2019
- Author(s)
  Sobue Yasumori、Takahashi Nobunori、Ohashi Yoshifumi、Suzuki Mochihito、Nishiume Tsuyoshi、Kobayakawa Tomonori、Terabe Kenya、Knudson Warren、Knudson Cheryl、Ishiguro Naoki、Kojima Toshihisa
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 14901-14901
- DOI
  10.1038/s41598-019-50166-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09620, KAKENHI-PROJECT-19H03779
[Journal Article] Hyaluronan promotes TRPV4-induced chondrogenesis in ATDC5 cells2019
- Author(s)
  Ogawa Yoshikazu、Takahashi Nobunori、Takemoto Toki、Nishiume Tsuyoshi、Suzuki Mochihito、Ishiguro Naoki、Kojima Toshihisa
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 8 Pages: e0219492-e0219492
- DOI
  10.1371/journal.pone.0219492
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09620
[Journal Article] mproved safety of biologic therapy for rheumatoid arthritis over the 8-year period since implementation in Japan: long-term results from a multicenter observational cohort study2016
- Author(s)
  Kojima, T., Takahashi, N., Funahashi, K., Asai, S., Terabe, K., Kaneko, A., Hirano, Y., Hayashi, M., Miyake, H., Oguchi, T., Takagi, H., Kanayama, Y., Yabe, Y., Watanabe, T., Fujibayashi, T., Shioura, T., Ito, T., Yoshioka, Y., Ishikawa, H., Asai, N., Takemoto, T., Kojima, M., Ishiguro, N.
- Journal Title
  
  Clinical Rheumatology
  
  Volume: 35 Issue: 4 Pages: 863-71
- DOI
  10.1007/s10067-016-3201-5
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462290, KAKENHI-PROJECT-25861307, KAKENHI-PROJECT-26460608
[Journal Article] Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model and inhibits M1 activation of RAW264.7 macrophages.2016
- Author(s)
  Matsumoto T, Takahashi N, Kojima T, Yoshioka Y, Ishikawa J, Furukawa K, Ono K, Sawada M, Ishiguro N, Yamamoto A.
- Journal Title
  
  Arthritis Research & Therapy
  
  Volume: 18（１） Issue: 1 Pages: 133-133
- DOI
  10.1186/s13075-016-1035-9
- NAID
  120006937643
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10897, KAKENHI-PROJECT-15K15080
[Journal Article] Hyaluronan Oligosaccharides Induce MMP-1 and -3 via Transcriptional Activation of NF-κB and p38 MAPK in Rheumatoid Synovial Fibroblasts.2016
- Author(s)
  Hanabayashi M, Takahashi N, Sobue Y, Hirabara S, Ishiguro N, Kojima T.
- Journal Title
  
  PLOS ONE
  
  Volume: 11（８） Issue: 8 Pages: e0161875-e0161875
- DOI
  10.1371/journal.pone.0161875
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K10897
[Journal Article] Disease activity early in treatment as a predictor of future low disease activity in RA patients treated with iguratimod.2016
- Author(s)
  Yoshioka Y, Takahashi N, Kaneko A, Hirano Y, Kanayama Y, Kanda H, Takagi H, Ito T, Kato T, Saito K, Funahashi K, Asai S, Takemoto T, Terabe K, Asai N, Ishiguro N, Kojima T.
- Journal Title
  
  Mod Rheumatol.
  
  Volume: 26(2) Issue: 2 Pages: 169-74
- DOI
  10.3109/14397595.2015.1069475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249076, KAKENHI-PROJECT-26670660
[Journal Article] Mechanical stress loading induces CD44 cleavage in human chondrocytic HCS-2/8 cells.2016
- Author(s)
  Kobayakawa T, Takahashi N, Sobue Y, Terabe K, Ishiguro N, Kojima T.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 478(3) Issue: 3 Pages: 1230-1235
- DOI
  10.1016/j.bbrc.2016.08.099
- NAID
  120006305561
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05446, KAKENHI-PROJECT-16K10897
[Journal Article] Hyaluronan Inhibits Tlr-4-Dependent RANKL Expression in Human Rheumatoid Arthritis Synovial Fibroblasts2016
- Author(s)
  Tatsuo Watanabe, Nobunori Takahashi, Shinya Hirabara, Naoki Ishiguro, Toshihisa Kojima
- Journal Title
  
  PLOS ONE
  
  Volume: in press Issue: 4 Pages: e0153142-e0153142
- DOI
  10.1371/journal.pone.0153142
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25462366, KAKENHI-PROJECT-26462290, KAKENHI-PROJECT-16K10897
[Journal Article] Respiratory mechanics measured by forced oscillation technique in rheumatoid arthritis-related pulmonary abnormalities: frequency-dependence, heterogeneity and effects of smoking.2016
- Author(s)
  Sokai R, Ito S, Iwano S, Uchida A, Aso H, Kondo M, Ishiguro N, Kojima T, Hasegawa Y.
- Journal Title
  
  SpringerPlus
  
  Volume: 5 Issue: 1 Pages: 335-335
- DOI
  10.1186/s40064-016-1952-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461188, KAKENHI-PROJECT-26462290
[Journal Article] Predictive factors for achieving low disease activity at 52 weeks after switching from tumor necrosis factor inhibitors to abatacept: results from a multicenter observational cohort study of Japanese patients2016
- Author(s)
  Kojima, T., Takahashi, N., Kaneko, A., Kida, D., Hirano, Y., Fujibayashi, T., Yabe, Y., Takagi, H., Oguchi, T., Miyake, H., Kato, T., Watanabe, T., Hayashi, M., Shioura, T., Kanayama, Y., Funahashi, K., Asai, S., Yoshioka, Y., Terabe, K., Takemoto, T., Asai, N., Ishiguro, N.
- Journal Title
  
  Clinical Rheumatology
  
  Volume: 35 Issue: 1 Pages: 219-25
- DOI
  10.1007/s10067-015-3135-3
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462290, KAKENHI-PROJECT-24249076, KAKENHI-PROJECT-26670660, KAKENHI-PROJECT-25861307
[Journal Article] Simvastatin inhibits CD44 fragmentation in chondrocytes.2016
- Author(s)
  Terabe K, Takahashi N, Takemoto T, Knudson W, Ishiguro N, Kojima T.
- Journal Title
  
  Archives of Biochemistry and Biophysics
  
  Volume: 604 Pages: 1-10
- DOI
  10.1016/j.abb.2016.05.019
- NAID
  120005868236
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05446, KAKENHI-PROJECT-16K10897
[Journal Article] Longterm Retention Rate and Risk Factors for Adalimumab Discontinuation Due To Efficacy and Safety in Japanese Patients with Rheumatoid Arthritis: An Observational Cohort Study.2016
- Author(s)
  Hattori Y, Kojima T, Kaneko A, Kida D, Hirano Y, Fujibayashi T, Terabe K, Yabe Y, Miyake H, Kato T, Takagi H, Hayashi M, Ito T, Kanayama Y, Oguchi T, Takahashi N, Ishikawa H, Funahashi K, Ishiguro N.
- Journal Title
  
  The Journal of Rheumatology
  
  Volume: 43(8) Issue: 8 Pages: 1475-9
- DOI
  10.3899/jrheum.151006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05446, KAKENHI-PROJECT-26462290
[Journal Article] Hyaluronan Oligosaccharides Induce MMP-1 and -3 via Transcriptional Activation of NF-kappaB and p38 MAPK in Rheumatoid Synovial Fibroblasts.2016
- Author(s)
  Hanabayashi M, Takahashi N, Sobue Y, Hirabara S, Ishiguro N, Kojima T.
- Journal Title
  
  PLoS One
  
  Volume: 11（８）
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462290
[Journal Article] Use of a 12-week observational period for predicting low disease activity at 52 weeks in RA patients treated with abatacept: a retrospective observational study based on data from a Japanese multicentre registry study.2015
- Author(s)
  Takahashi N, Kojima T, Kaneko A, Kida D, Hirano Y, Fujibayashi T, Yabe Y, Takagi H, Oguchi T, Miyake H, Kato T, Fukaya N, Hayashi M, Tsuboi S, Kanayama Y, Funahashi K, Hanabayashi M, Hirabara S, Asai S, Yoshioka Y, Ishiguro N
- Journal Title
  
  Rheumatology (Oxford)
  
  Volume: 54(5) Issue: 5 Pages: 854-859
- DOI
  10.1093/rheumatology/keu418
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670660
[Journal Article] Importance of methotrexate therapy concomitant with tocilizumab treatment in achieving better clinical outcomes for rheumatoid arthritis patients with high disease activity: an observational cohort study2015
- Author(s)
  Kojima, T.,Yabe, Y.,Kaneko, A.,Takahashi, N.,Funahashi, K.,Kato, D.,Hanabayashi, M.,Asai, S.,Hirabara, S.,,Asai, ,.Hirano, Y.,Hayashi, M.,Miyake, H.,Kojima, M.,Ishiguro, N.
- Journal Title
  
  Rheumatology (Oxford)
  
  Volume: 54（1） Issue: 1 Pages: 113-120
- DOI
  10.1093/rheumatology/keu302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861307, KAKENHI-PROJECT-26462290, KAKENHI-PROJECT-26460608
[Journal Article] Concomitant Methotrexate Protects Against Total Knee Arthroplasty in Patients with Rheumatoid Arthritis Treated with Tumor Necrosis Factor Inhibitors.2015
- Author(s)
  Asai S, Takahashi N, Funahashi K, Yoshioka Y, Takemoto T, Terabe K, Asai N, Ishiguro N, Kojima T.
- Journal Title
  
  J Rheumatol.
  
  Volume: 42(12) Issue: 12 Pages: 2255-60
- DOI
  10.3899/jrheum.150410
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249076, KAKENHI-PROJECT-26670660
[Journal Article] Drug retention rates of second biologic agents after switching from tumor necrosis factor inhibitors for rheumatoid arthritis in Japanese patients on low-dose methotrexate or without methotrexate2015
- Author(s)
  Kobayakawa, T.,Kojima, T.,Takahashi, N.,Hayashi, M.,Yabe, Y.,Kaneko, A.,Shioura, T.,Saito, K.,Hirano, Y.,Kanayama, Y.,Miyake, H.,Asai, N.,Funahashi, K.,Hirabara, S.,Hanabayashi, M.,Asai, S.,Ishiguro, N.
- Journal Title
  
  Mod Rheumatol
  
  Volume: 25（2） Issue: 2 Pages: 251-256
- DOI
  10.3109/14397595.2014.953668
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861307, KAKENHI-PROJECT-26462290
[Journal Article] Longterm efficacy and safety of abatacept in patients with rheumatoid arthritis treated in routine clinical practice: effect of concomitant methotrexate after 24 weeks.2015
- Author(s)
  Takahashi N, Kojima T, Kaneko A, Kida D, Hirano Y, Fujibayashi T, Yabe Y, Takagi H, Oguchi T, Miyake H, Kato T, Watanabe T, Hayashi M, Kanayama Y, Funahashi K, Asai S, Yoshioka Y, Takemoto T, Terabe K, Asai N, Ishiguro N.
- Journal Title
  
  J Rheumatol.
  
  Volume: 42(5) Issue: 5 Pages: 786-93
- DOI
  10.3899/jrheum.141288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249076, KAKENHI-PROJECT-26670660
[Journal Article] Effects of Concomitant Methotrexate on Large Joint Replacement in Patients With Rheumatoid Arthritis Treated With Tumor Necrosis Factor Inhibitors: A Multicenter Retrospective Cohort Study in Japan.2015
- Author(s)
  Asai S, Kojima T, Oguchi T, Kaneko A, Hirano Y, Yabe Y, Kanayama Y, Takahashi N, Funahashi K, Hanabayashi M, Hirabara S, Yoshioka Y, Takemoto T, Terabe K, Asai N, Ishiguro N.
- Journal Title
  
  Arthritis Care Res (Hoboken).
  
  Volume: 67(10) Issue: 10 Pages: 1363-70
- DOI
  10.1002/acr.22596
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249076, KAKENHI-PROJECT-26670660
[Journal Article] Concomitant methotrexate and tacrolimus augment the clinical response to abatacept in patients with rheumatoid arthritis with a prior history of biological DMARD use.2015
- Author(s)
  Takahashi N, Fujibayashi T, Kida D, Hirano Y, Kato T, Kato D, Saito K, Kaneko A, Yabe Y, Takagi H, Oguchi T, Miyake H, Watanabe T, Hayashi M, Kanayama Y, Funahashi K, Hanabayashi M, Hirabara S, Asai S, Takemoto T, Terabe K, Asai N, Yoshioka Y, Ishiguro N, Kojima T.
- Journal Title
  
  Rheumatol Int.
  
  Volume: 35(10) Issue: 10 Pages: 1707-16
- DOI
  10.1007/s00296-015-3283-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249076, KAKENHI-PROJECT-26670660
[Journal Article] Clinical efficacy of abatacept, tocilizumab, and etanercept in Japanese rheumatoid arthritis patients with inadequate response to anti-TNF monoclonal antibodies2014
- Author(s)
  Y.,Fujibayashi, T.,Sugiura, F.,Hayashi, M.,Funahashi, K.,Hanabayashi, M.,Asai, S.,Ishiguro, N.,Kojima, T.
- Journal Title
  
  Clin Rheumatol
  
  Volume: 33（９） Issue: 9 Pages: 1247-1254
- DOI
  10.1007/s10067-014-2711-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861307, KAKENHI-PROJECT-26462290
[Journal Article] Alexithymia, Depression, Inflammation and Pain in Patients with Rheumatoid Arthritis2014
- Author(s)
  Kojima M, Kojima T, Suzuki S, Takahashi N, Funahashi K, Kato D, Hanabayashi M, Hirabara S, Asai S, Ishiguro N
- Journal Title
  
  Arthritis Care Res
  
  Volume: 66(5) Issue: 5 Pages: 679-86
- DOI
  10.1002/acr.22203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590708
[Journal Article] Longterm retention rate and risk factor for discontinuation due to insufficient efficacy and adverse events in Japanese patients with rheumatoid arthritis receiving etanercept therapy2014
- Author(s)
  Matsubara H, Kojima T, Kaneko A, Hirano Y, Ishikawa H, Hattori Y, Miyake H, Oguchi T, Takagi H, Yabe Y, Kato T, Ito T, Fukaya N, Kanayama Y, Shioura T, Hayashi M, Fujibayashi T, Takahashi N, Funahashi K, Kato D, Hanabayashi M, Terabe K, Ishiguro N.
- Journal Title
  
  J Rheumatol
  
  Volume: 41 Issue: 8 Pages: 1583-9
- DOI
  10.3899/jrheum.130901
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26462290
[Journal Article] 関節リウマチ患者は薬物治療の変化をどのように感じているか　フォーカスグループによる質的研究2013
- Author(s)
  小嶋雅代, 小嶋俊久, 難波大夫, 茂木七香, 大谷尚, 高橋伸典, 加藤大三, 舟橋康治, 松原浩之, 服部陽介, 石黒直樹
- Journal Title
  
  中部リウマチ
  
  Volume: 43 Pages: 17-20
- Data Source
  KAKENHI-PROJECT-21590708
[Journal Article] 周術期患者における死亡率と心血管イベントの発現2013
- Author(s)
  小嶋　雅代
- Journal Title
  
  リウマチ科
  
  Volume: 49 Pages: 471-478
- Data Source
  KAKENHI-PROJECT-21590708
[Journal Article] 周術期患者における死亡率と心血管イベントの発現2013
- Author(s)
  小嶋雅代
- Journal Title
  
  リウマチ科
  
  Volume: 49巻4号 Pages: 471-748
- Data Source
  KAKENHI-PROJECT-21590708
[Journal Article] 関節リウマチ患者は薬物治療の変化をどのように感じているかフォーカスグループによる質的研究2013
- Author(s)
  小嶋雅代, 小嶋俊久, 難波大夫, 茂木七香, 大谷尚, 高橋伸典,加藤大三, 舟橋康治, 松原浩之, 服部陽介, 石黒直樹
- Journal Title
  
  中部リウマチ
  
  Volume: 43巻1号 Pages: 17-20
- Data Source
  KAKENHI-PROJECT-21590708
[Journal Article] Epidemiologic studies of psychosocial factors associated with quality of life among patients with chronic diseases in Japan.2012
- Author(s)
  Masayo Kojima
- Journal Title
  
  Journal of Epidemiology
  
  Volume: 22 Pages: 7-11
- NAID
  10030212906
- Data Source
  KAKENHI-PROJECT-21590708
[Journal Article] Alexithymia as a prognostic risk factor for health problems : a brief review of epidemiological studies2012
- Author(s)
  Kojima M
- Journal Title
  
  Biopsychosom Med
  
  Volume: 6(1) Issue: 1 Pages: 21-21
- DOI
  10.1186/1751-0759-6-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590708
[Journal Article] Epidemiologic Studies of Psychosocial Factors Associated With Quality of Life Among Patients With Chronic Diseases in Japan2012
- Author(s)
  Kojima M
- Journal Title
  
  Journal of Epidemiology
  
  Volume: 22 Issue: 1 Pages: 7-11
- DOI
  10.2188/jea.JE20110114
- NAID
  10030212906
- ISSN
  0917-5040, 1349-9092
- Language
  English
- Data Source
  KAKENHI-PROJECT-21590708
[Journal Article] 慢性疾患患者のQOLと疫学2011
- Author(s)
  小嶋雅代
- Journal Title
  
  Quality of Life Journal
  
  Volume: 12巻1号 Pages: 85-90
- Data Source
  KAKENHI-PROJECT-21590708
[Journal Article] Study protocol of a multicenter registry of patients with rheumatoid arthritis starting biologic therapy in Japan : Tsurumai Biologics Communication Registry (TBCR) Study2011
- Author(s)
  Kojima T, Kaneko A, Hirano Y, Ishikawa H, Miyake H, Oguchi T, Takagi H, Yabe Y, Kato T, Ito T, Terabe K, Fukaya N, Kanayama Y, Shioura T, Funahashi K, Hayashi M, Kato D, Matsubara H, Fujibayashi T, Kojima M, Ishiguro N
- Journal Title
  
  Mod Rheumatol
  
  Volume: 22(3) Issue: 3 Pages: 339-45
- DOI
  10.1007/s10165-011-0518-4
- NAID
  10030782076
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390419, KAKENHI-PROJECT-21590708, KAKENHI-PROJECT-22659269
[Journal Article] 関節リウマチ患者の痛み、うつ、QOL2011
- Author(s)
  小嶋雅代
- Journal Title
  
  メディカル朝日
  
  Volume: 40巻6号 Pages: 38-39
- Data Source
  KAKENHI-PROJECT-21590708
[Journal Article] Depression, Alexithymia and Long-term Mortality in Chronic Hemodialysis Patients2010
- Author(s)
  Kojima M, Hayano J, Suzuki S, Seno H, Kasuga H, Takahashi H, Toriyama T, Kawahara H, Furukawa TA
- Journal Title
  
  Psychother Psychosom
  
  Volume: 79 Issue: 5 Pages: 303-11
- DOI
  10.1159/000319311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590708
[Journal Article] Depression, Alexithymia and Long-term Mortality in Chronic Hemodialysis Patients.2010
- Author(s)
  Kojima M, Hayano J, Suzuki S, Seno H, Kasuga H, Takahashi H, Toriyama T, Kawahara H, Furukawa TA
- Journal Title
  
  Psychother Psychosom
  
  Volume: 79 Pages: 303-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590708
[Journal Article] Exploring the link between depression and rheumatoid arthritis : prospects for optimal therapeutic success.2010
- Author(s)
  Kojima M, Kojima T, Furukawa TA, Ishiguro N
- Journal Title
  
  Int.J.Clin.Rheumatol
  
  Volume: 5 Pages: 273-275
- Data Source
  KAKENHI-PROJECT-21590708
[Journal Article] Exploring the link between depression and rheumatoid arthritis : prospects for optimal therapeutic success2010
- Author(s)
  Kojima M, Kojima T, Furukawa TA, Ishiguro N
- Journal Title
  
  Int. J. Clin. Rheumatol
  
  Volume: 5(3) Issue: 3 Pages: 273-275
- DOI
  10.2217/ijr.10.19
- Data Source
  KAKENHI-PROJECT-21590708
[Journal Article] Psychosocial factors, disease status, and quality of life in patients with rheumatoid arthritis2009
- Author(s)
  Kojima M, Kojima T, Ishiguro N, Oguchi T, Oba M, Tsuchiya H, Sugiura F, Furukawa TA, Suzuki S, Tokudome S.
- Journal Title
  
  J Psychosom Res 67
  
  Pages: 425-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590708
[Journal Article] Psychosocial factors, disease status, and quality of life in patients with rheumatoid arthritis2009
- Author(s)
  Kojima M, Kojima T, Ishiguro N, Oguchi T, Oba M, Tsuchiya H, Sugiura F, Furukawa TA, Suzuki S, Tokudome S
- Journal Title
  
  J Psychosom Res
  
  Volume: 67 Issue: 5 Pages: 425-31
- DOI
  10.1016/j.jpsychores.2009.01.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590708
[Journal Article] .A case of lung tuberculosis in a patient with rheumatoid arthritis treated with infliximab after anti-tuberculosis chemoprophylaxis with isoniazid.2009
- Author(s)
  Yuji Hirano, Toshihisa Kojima, Yasuhide Kanayama, Hisato Ishikawa, Naoki Ishiguro
- Journal Title
  
  Modern Rheumatology 19(3)
  
  Pages: 323-328
- NAID
  10025113203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659230
[Journal Article] Depression, Inflammation, and Pain in Rheumatoid Arthritis Patients2009
- Author(s)
  Kojima M, Kojima T, Suzuki S, Oguchi T, Oba M, Tsuchiya H, Sugiura F, Kanayama Y, Furukawa TA, Tokudome S, Ishiguro N
- Journal Title
  
  Arthritis Rheum
  
  Volume: 61 Issue: 8 Pages: 1018-24
- DOI
  10.1002/art.24647
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590708
[Journal Article] Depression, Inflammation, and Pain in Rheumatoid Arthritis Patients2009
- Author(s)
  Kojima M, Kojima T, Suzuki S, Oguchi T, Oba M, Tsuchiya H, Sugiura F, Kanayama Y, Furukawa TA, Tokudome S, Ishiguro N
- Journal Title
  
  Arthritis Care Res 61
  
  Pages: 18-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590708
[Journal Article] JACC Study Group. Insulin-like growth factor (IGF)-I, IGF-II, IGF binding protein-3, and risk of colorectal cancer : a nested case-control study in the Japan Collaborative Cohort study2009
- Author(s)
  Suzuki S, Kojima M, Tokudome S, Suzuki K, Ozasa K, Ito Y, Inaba Y, Tajima K, Nakachi K, Watanabe Y, Tamakoshi A
- Journal Title
  
  Asian Pac J Cancer Prev
  
  Volume: 10 (Suppl) Pages: 45-9
- URL
  http://www.apocpcontrol.org/
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590708
[Journal Article] Influences of menopause, aging, and gender on the cleavage of type II collagen in cartilage in relationship to bone turnover2008
- Author(s)
  T Kojima, M Kojima, K Noda, N lshiguro, AR Poole
- Journal Title
  
  Menopause 15
  
  Pages: 133-137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659230
[Journal Article] Influences of menopause, aging, and gender on the cleavage of type II collagen in cartilage in relationship to bone turnover2008
- Author(s)
  T Kojima, M Kojima, K Noda, N Ishiguro, AR Poole
- Journal Title
  
  Menopause 15
  
  Pages: 133-137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659440
[Journal Article] Correlation between parathyroid hormone, bone alkaline phosphatase and N-telopeptide of type 1 collagen in diabetic and non-diabetic haemodialysis patients2007
- Author(s)
  N Takahashi, T Kojima, H Ogawa, N Ishiguro
- Journal Title
  
  Nephrology 12
  
  Pages: 539-545
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659440
[Journal Article] Mechanism of Cartilage Destruction in Osteoarthritis.2002
- Author(s)
  Naoki Ishiguro, Toshihisa Kojima, A.Robin Poole.
- Journal Title
  
  Nagoya J Med Sci 65
  
  Pages: 73-84
- NAID
  110000023229
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370461
[Journal Article] Mechanism of Cartilage Destruction in Osteoarthritis2002
- Author(s)
  Naoki Ishiguro, Toshihisa Kojima, A.Robin Poole
- Journal Title
  
  Nagoya J Med Sci 65
  
  Pages: 73-84
- NAID
  110000023229
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370461
[Patent] 肺炎の治療および予防用医薬組成物2008
- Inventor(s)
  石黒直樹, 藤林孝義, 小嶋俊久
- Industrial Property Rights Holder
  国立大学法人名古屋大学エーザイ株式会社
- Industrial Property Number
  2008-241066
- Filing Date
  2008-10-17
- Data Source
  KAKENHI-PROJECT-20659230
[Presentation] フレイルの現状と脱却への視点　関節リウマチ治療におけるフレイル予防のための治療目標としてのHAQ寛解の妥当性2023
- Author(s)
  小嶋俊久, 浅井秀司, 鈴木望人, 寺部健哉, 大橋禎史, 岸本賢治, 紀平大介, 前田真崇, 佐藤良, 服部陽介, 永井薫, 小嶋雅代, 今釜史郎
- Organizer
  第67回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] 関節リウマチ患者の笑いとフレイルの関係について～Fairy studyより～2023
- Author(s)
  鈴木望人, 小嶋俊久, 大橋禎史, 佐藤良, 紀平大介, 前田真崇, 岸本賢治, 寺部健哉, 浅井秀司, 今釜史郎
- Organizer
  第96回日本整形外科学会学術総会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] 脂質代謝制御による軟骨保護作用の検討2023
- Author(s)
  佐藤良　寺部健哉　高橋伸典　大橋禎史　紀平大介　前田真崇　小杉山裕旦　長谷川純也　浅井秀司　小嶋俊久　今釜史郎
- Organizer
  日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-19K09619
[Presentation] 関節リウマチ患者の笑いとフレイルの関係について～Fairy studyより～2023
- Author(s)
  鈴木望人, 小嶋俊久, 大橋禎史, 佐藤良, 紀平大介, 前田真崇, 岸本賢治, 寺部健哉, 浅井秀司, 今釜史郎
- Organizer
  第67回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] 関節リウマチ治療におけるフレイル予防のための治療目標としてのHAQ寛解の妥当性2023
- Author(s)
  小嶋俊久, 浅井秀司, 寺部健哉, 鈴木望人, 大橋禎史, 岸本賢治, 紀平大介, 佐藤良, 服部陽介, 小嶋雅代, 今釜史郎
- Organizer
  第96回日本整形外科学会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] 看護とチーム医療-2　リウマチ患者の転倒に関する身体能力と患者健康観2023
- Author(s)
  永井薫, 小嶋雅代, 小嶋俊久, 今釜史郎
- Organizer
  第67回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] 関節リウマチ患者におけるフレイルと，その治療選択との関連2022
- Author(s)
  小嶋俊久，鈴木望人，大橋禎史，浅井秀司，高橋伸典，寺部健哉，岸本賢治，服部恭典，永井薫，今釜史郎，小嶋雅代
- Organizer
  第66回日本リウマチ学会総会総会・学術集会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] 関節リウマチ既往者の身体機能、認知機能の経年変化2022
- Author(s)
  安岡実佳子，丹下智香子，西田裕紀子，富田真紀子，渡邉良太，下方浩史，大塚礼，小嶋雅代
- Organizer
  第32回日本疫学会学術総会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] 介護予防・日常生活圏域ニーズ調査の基本チェックリストは要介護認定発生を予測するかーJAGESコホート研究ー2022
- Author(s)
  渡邉良太、辻大士、井手一茂、野口泰司、安岡実佳子、上地香杜、佐竹昭介、近藤克則、小嶋雅代
- Organizer
  第32回日本疫学会学術総会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] 関節リウマチ患者の予後予測指標としてのフレイルの妥当性検証2022
- Author(s)
  小嶋雅代，安岡実佳子，浅井秀司，祖父江康司，西梅剛，鈴木望人，高橋伸典，黒柳元，川口洋平，上用祐士，坂井宏章，永谷祐子，小嶋俊久
- Organizer
  第66回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] 高齢発症関節リウマチの治療戦略の確立：既存疫学データによる治療実態の把握2022
- Author(s)
  小嶋雅代，杉原毅彦，松井利浩，田中榮一，小嶋俊久，大西輝，伊藤宣，川人豊，針谷正祥
- Organizer
  第64回日本老年医学会学術集会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] 脂質代謝制御による軟骨保護作用の検討2022
- Author(s)
  佐藤良　寺部健哉　高橋伸典　大橋禎史　紀平大介　前田真崇　小杉山裕亘　長谷川純也　小嶋俊久　今釜史郎
- Organizer
  日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-19K09619
[Presentation] Metabolic reprogramming via glutamine metabolism in chondrocytes under inflammatory conditions2022
- Author(s)
  Kihira Daisuke;Nobunori Takahashi;Kenya Terabe; Toshihisa Kojima;Yoshifumi Ohashi;Masataka Maeda;Ryo Sato;Hironobu Kosugiyama;Jyunya Hasegawa;Shiro Imagama
- Organizer
  Orthopaedic Research Society 2021 Annual Meeting Registration
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09620
[Presentation] 軟骨細胞におけるグルタミン代謝阻害による抗炎症作用の検討2022
- Author(s)
  紀平　大介、高橋　伸典、寺部　健哉、大橋　禎史、小嶋　俊久、今釜　史郎
- Organizer
  第 34 回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-19K09620
[Presentation] 関節炎の炎症抑制における脂肪酸代謝の関与2022
- Author(s)
  佐藤　良、寺部　健哉、大橋　禎史、高橋　伸典、小嶋　俊久、今釜　史郎
- Organizer
  第 34 回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-19K09620
[Presentation] ＫＤＢデータと自記式質問紙調査を用いたフレイルハイリスク者の把握2022
- Author(s)
  小嶋雅代
- Organizer
  第81回日本公衆衛生学会総会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] 地域在住高齢者における関節リウマチの診断とフレイル、社会的背景に関する検討：JAGES横断研究2022
- Author(s)
  小嶋雅代, 渡邉良太, 安岡実佳子, 竹内研時, 斎藤民, 寺部健哉, 小嶋俊久, 尾島俊之, 近藤克則
- Organizer
  第32回日本疫学会学術総会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] 軟骨細胞におけるグルタミン代謝阻害による抗炎症効果の検討2022
- Author(s)
  紀平大介　寺部健哉　大橋禎史　前田真崇　小杉山裕亘　佐藤良　長谷川純也　高橋伸典　小嶋俊久　今釜史郎
- Organizer
  日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-19K09619
[Presentation] 高分子ヒアルロン酸のNF-kB経路に対する影響の検討2022
- Author(s)
  小杉山　裕亘、高橋　伸典、寺部　健哉、大橋　禎史、小嶋　俊久
- Organizer
  第 34 回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-19K09620
[Presentation] Metabolic Reprogramming In Chondrocytes To Promote Mitochondrial Respiration Reduces Downstream Features Of Osteoarthritis2022
- Author(s)
  Yoshifumi Ohashi; Nobunori Takahashi; Kenya Terabe; Saho Tsuchiya; Toshihisa Kojima; Warren Knudson; Cheryl Knudson; Shiro Imagama
- Organizer
  Orthopaedic Research Society 2021 Annual Meeting Registration
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09620
[Presentation] 軟骨細胞における細胞内代謝変動の網羅的解析による検討2022
- Author(s)
  寺部健哉　前田真崇　紀平大介　佐藤良　小杉山裕亘　長谷川純也　高橋伸典　小嶋俊久
- Organizer
  日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-19K09619
[Presentation] AICARの軟骨保護には細胞内代謝の変化が関係する2022
- Author(s)
  前田　真崇、寺部　健哉、浅井　秀司、高橋　伸典、小嶋　俊久、今釜　史郎
- Organizer
  第 34 回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-19K09620
[Presentation] 地域在住高齢者大規模コホートデータに基づく基礎疾患リスク指数の開発2021
- Author(s)
  小嶋雅代，上地香杜，安岡実佳子，飯塚玄明，勝山陽太，尾島俊之，近藤克則
- Organizer
  第31回日本疫学会学術総会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] 長期罹病関節リウマチ患者のフレイルの状況と関節手術との関連2021
- Author(s)
  小嶋俊久, 高橋伸典, 浅井秀司, 寺部健哉, 鈴木望人, 横田裕, 大橋禎史, 岸本賢治, 今釜史郎, 小嶋雅代
- Organizer
  第65回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] 関節リウマチ患者の抑うつと痛み，炎症との関連は生物学的製剤の登場により変化したか2021
- Author(s)
  小嶋雅代，高橋伸典，浅井秀司，寺部健哉，鈴木望人，横田裕，大橋禎史，岸本賢治，小嶋俊久
- Organizer
  第65回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] 関節リウマチ患者におけるフレイルが患者全般評価に及ぼす影響について2021
- Author(s)
  鈴木望人, 浅井秀司, 祖父江康司, 大橋禎史, 寺部健哉,高橋伸典, 小嶋俊久, 今釜史郎
- Organizer
  第65回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] ロコモ度3に着目した関節リウマチ患者におけるロコモティブシンドロームとフレイルの関連について2021
- Author(s)
  祖父江康司, 石川尚人, 鈴木望人, 大橋禎史, 小嶋俊久, 井上英則
- Organizer
  第94回日本整形外科学会学術総会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] 関節リウマチ患者における身体機能評価とフレイル・サルコペニアとの関連2021
- Author(s)
  小嶋雅代，花林雅裕，斉藤究，金山康秀，小口武，伊藤隆安，渡部達生，渡邉剛，渡邉良太，安岡実佳子，小嶋俊久，津下一代
- Organizer
  第36回日本臨床リウマチ学会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] 関節リウマチ患者における精神的QOLに対する手術療法の長期的影響2021
- Author(s)
  小嶋俊久,小嶋雅代,高橋伸典,浅井秀司,寺部健哉,鈴木望人,大橋禎史,岸本賢治,服部恭典,安岡実佳子,永谷裕子,今釜史郎
- Organizer
  第36回日本臨床リウマチ学会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] 関節リウマチにおける軟骨破壊メカニズムとその制御2021
- Author(s)
  小嶋俊久, 高橋伸典,寺部健哉,鈴木望人,大橋禎史, 岸本賢治,服部恭典,浅井秀司,今釜史郎
- Organizer
  第32回中部リウマチ学会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] 関節リウマチにおけるJ-CHS基準に基づいたフレイルの関連因子2021
- Author(s)
  大橋禎史, 浅井秀司, 寺部健哉, 高橋伸典, 鈴木望人, 祖父江康司, 小嶋俊久, 今釜史郎
- Organizer
  第94回日本整形外科学会学術総会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] 関節リウマチ関節患者における医療への満足度に関わる因子の検討2021
- Author(s)
  紀平　大介, 小嶋雅代,安岡実佳子,永谷祐子,高橋伸典,浅井秀司,寺部健哉,西梅剛,鈴木望人,横田裕,大橋禎史,小嶋俊久
- Organizer
  第32回中部リウマチ学会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] 高齢者関節リウマチ患者におけるフレイルが患者全般評価に及ぼす影響について2021
- Author(s)
  鈴木望人,浅井秀司,祖父江康司,大橋禎史,寺部健哉,高橋伸典,小嶋俊久,今釜史郎
- Organizer
  第36回日本臨床リウマチ学会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] 「フレイルと後期高齢者健診」2021
- Author(s)
  小嶋雅代
- Organizer
  第63回日本老年医学会学術集会・シンポジウム17
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] The activation of transient receptor potential vanilloid-4 inhibits IL-1β-induced articular cartilage degradation via regulation of the CaMKK/AMPK/NF-κB signaling pathway.2021
- Author(s)
  Kyosuke Hattori, Nobunori Takahashi, Kenya Terabe, Toshihisa Kojima et al.
- Organizer
  Orthopedic Research society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09619
[Presentation] 関節リウマチ患者における握力とフレイルの関連について2021
- Author(s)
  祖父江康司, 石川尚人, 鈴木望人, 大橋禎史, 小嶋俊久
- Organizer
  第65回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] 「フレイルの社会的側面」ーその概念および研究と社会実装ー2021
- Author(s)
  小嶋雅代
- Organizer
  第32回日本老年学会総会・合同シンポジウム10
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] 関節リウマチにおけるJ-CHS基準に基づいたフレイルの関連因子2021
- Author(s)
  大橋　禎史,浅井秀司，服部恭典,岸本賢治,鈴木望人,寺部健哉,高橋伸典,小嶋俊久,祖父江康司
- Organizer
  第32回中部リウマチ学会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] 関節リウマチ患者における介護ニーズとフレイルに関する検討2020
- Author(s)
  小嶋雅代, 小嶋俊久, 石黒直樹, 永谷祐子, 鈴木貞夫, 松井康素, 荒井秀典
- Organizer
  第62回日本老年医学会学術総会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] 関節リウマチの疫学－メンタルヘルスとフレイルを中心に－2020
- Author(s)
  小嶋雅代
- Organizer
  第64回日本リウマチ学会総会・学術集会; 教育講演
- Invited
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] フレイル状態にある関節リウマチ患者と地域在住高齢者の比較検討2020
- Author(s)
  上地香杜, 小嶋雅代, 安岡実佳子, 武藤剛, 飯塚玄明, 斎藤民, 渡邉美貴, 鈴木貞夫, 竹内研時, 若井建志, 尾島俊之, 近藤克則
- Organizer
  第79回日本公衆衛生学会総会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] The activation of transient receptor potential vanilloid-4 inhibits IL-1β-induced articular cartilage degradation via regulation of the CaMKK/AMPK/NF-κB signaling pathway.2020
- Author(s)
  服部恭典　高橋伸典　寺部健哉　小嶋俊久他
- Organizer
  日本整形外科基礎学術集会
- Data Source
  KAKENHI-PROJECT-19K09619
[Presentation] 患者の価値観・意向の評価2020
- Author(s)
  小嶋雅代，長谷川三枝子,　川人豊,　伊藤宣,　金子祐子,　岸本暢将,　河野正孝,　小嶋俊久,　杉原毅彦,　瀬戸洋平,　田中榮一,　西田圭一郎,　平田信太郎,　松下功,　村島温子,　森信暁雄,　森雅亮,　山中寿,　針谷正祥．
- Organizer
  第64回日本リウマチ学会総会・学術集会；シンポジウム
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] 社会参加とフレイル：関節リウマチ患者と「健康とくらしの調査2016」参加者との比較2020
- Author(s)
  小嶋雅代，上地香杜，安岡実佳子，武藤　剛，飯塚玄明，斎藤　民，渡邉美貴，鈴木貞夫，竹内研時，若井建志，尾島俊之，近藤克則．
- Organizer
  第79回日本公衆衛生学会総会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] ロコモティブシンドローム，動作速度から見たRA患者の身体機能．2020
- Author(s)
  祖父江　康司，小嶋　俊久，舟橋　康治，高橋　伸典，浅井　秀司，寺部　健哉，鈴木　望人，西梅　剛，横田　裕，石黒　直樹．
- Organizer
  第64回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] 関節リウマチ患者におけるフレイルの背景要因に関する検討2020
- Author(s)
  小嶋雅代，永谷祐子，野崎正浩，三井裕人，川口洋平，黒柳　元，高橋伸典，浅井秀司，浅井信之，祖父江康司，西梅　剛，鈴木望人，小嶋俊久．
- Organizer
  第64回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] 長期罹病関節リウマチ患者における関節手術の抑うつに対する効果　多施設前向きコホート研究より．2020
- Author(s)
  小嶋　俊久,小嶋　雅代,石川　肇,田中　栄,芳賀　信彦,西田　圭一郎,行岡　正雄,橋本　淳,宮原　寿明,二木　康夫,石黒　直樹．
- Organizer
  第93回日本整形外科学会学術総会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] 関節リウマチ患者におけるソーシャルサポートと抑うつとの関連2020
- Author(s)
  安岡実佳子, 小嶋雅代, 上地香杜, 渡邉美貴, 鈴木貞夫, 斎藤民, 尾島俊之, 近藤克則
- Organizer
  第79回日本公衆衛生学会総会
- Data Source
  KAKENHI-PROJECT-23K20339
[Presentation] IL-1b刺激による軟骨細胞の代謝リプログラミングに対するヒアルロン酸の効果2019
- Author(s)
  横田裕　高橋伸典　石黒直樹　小嶋俊久
- Organizer
  第34回日本整形外科基礎学術集会
- Data Source
  KAKENHI-PROJECT-19K09619
[Presentation] IL-1b存在下におけるTRPV4の軟骨破壊に対する役割の検討2019
- Author(s)
  服部恭典　高橋伸典　石黒直樹　小嶋俊久
- Organizer
  第34回日本整形外科基礎学術集会
- Data Source
  KAKENHI-PROJECT-19K09619
[Presentation] ADAM10 阻害剤がウシ初代軟骨細胞において機械的ストレスによる軟骨脱分化を抑制する2017
- Author(s)
  祖父江康司,高橋伸典,石黒直樹,小嶋俊久
- Organizer
  第30回日本軟骨代謝学会
- Place of Presentation
  京都市勧業館みやこめっせ（京都府京都市）
- Year and Date
  2017-03-03
- Data Source
  KAKENHI-PROJECT-16K10897
[Presentation] ADAM10 inhibitor suppresses CD44 cleavage and chondrogenic dedifferentiation in bovine primary chondrocyte cells2017
- Author(s)
  Yasumori Sobue, Nobunori Takahashi, Naoki Ishiguro, Toshihisa Kojima
- Organizer
  The Orthopaedic Research Society 2017 Annual Meeting
- Place of Presentation
  San Diego （ＵＳＡ）
- Year and Date
  2017-03-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10897
[Presentation] DKK-1 分子発現亢進による新規変形性関節症治療薬の開発―DKK-1promoter 領域とpGL4.10 をつないだconstruct 作成2017
- Author(s)
  西梅剛,高橋伸典,小嶋俊久,石黒直樹,大河原美静,大野欣司
- Organizer
  第30回日本軟骨代謝学会
- Place of Presentation
  京都市勧業館みやこめっせ（京都府京都市）
- Year and Date
  2017-03-03
- Data Source
  KAKENHI-PROJECT-16K10897
[Presentation] Mechanisms　of Cartilage destruction in osteoarthritis and rheumatoid arthritis2017
- Author(s)
  小嶋俊久
- Organizer
  日本軟骨代謝学会
- Place of Presentation
  京都市勧業館みやこめっせ（京都府京都市）
- Year and Date
  2017-03-03
- Invited
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] 軟骨様細胞株(HCS2/8) において、カテプシンK の発現はTRPV4 刺激により亢進する2017
- Author(s)
  鈴木望人,高橋伸典,祖父江康司,小嶋俊久,石黒直樹
- Organizer
  第30回日本軟骨代謝学会
- Place of Presentation
  京都市勧業館みやこめっせ（京都府京都市）
- Year and Date
  2017-03-03
- Data Source
  KAKENHI-PROJECT-16K10897
[Presentation] The Mechanical Stress Loading Can Induce The Fragmetation Of Cd44 by increased ADAM-10 expression In A Chondrocyte Cell Line.2016
- Author(s)
  Kobayakawa T, Takahashi N, Kojima T, Ishiguro N
- Organizer
  Orthopaedic Research Society
- Place of Presentation
  オーランド,アメリカ
- Year and Date
  2016-03-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670660
[Presentation] The Mechanical Stress Loading Can Induce The Fragmetation Of CD44 by increased ADAM-10 expression In A Chondrocyte Cell Line2016
- Author(s)
  小早川知範　高橋伸典　小嶋俊久　石黒直樹
- Organizer
  62nd annual meeting of Orthopaedic Research Society
- Place of Presentation
  オーランド（米国）
- Year and Date
  2016-03-05
- Data Source
  KAKENHI-PROJECT-25462366
[Presentation] THE PREDICTORS FOR 12 MONTHS EFFICACY OF DENOSUMAB, AN ANTI-RANKL ANTIBODY, ON OSTEOPOROSIS IN PATIENTS WITH RHEUMATOID ARTHRITIS FROM MULTICENTER STUDY (TBCR-BONE)2016
- Author(s)
  Y. Hirano, Y. Kanayama, M. Isono, N. Ishiguro, T. Kojima, on behalf of TBCR-BONE
- Organizer
  ＥＵＬＡＲ
- Place of Presentation
  London（ＵＫ）
- Year and Date
  2016-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] Hyaluronan Inhibits TLR-4 Dependent RANKL Expression in Human Rheumatoid Arthritis Synovial Fibroblast2016
- Author(s)
  Watanabe T, Takahashi N, Ishiguro N, Kojima T
- Organizer
  第29回日本軟骨代謝学
- Place of Presentation
  広島大学（広島県広島市）
- Year and Date
  2016-02-19
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] Influence of glucocorticoids on effect of denosumab on osteoporosis in patients with Japanese rheumatoid arthritis; 12 months of followup ~a Multicenter Registry Study~2016
- Author(s)
  Y. Kanayama, Y. Hirano, N. Takahashi, S. Asai, N. Ishiguro, T. Kojima, on behalf of TBCR-BONE Study Group
- Organizer
  ＡＳＢＭＲ
- Place of Presentation
  Atlanta（ＵＳＡ）
- Year and Date
  2016-09-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] PROGNOSTIC FACTORS FOR ABATACEPT RETENTION IN PATIENTS WITH RHEUMATOID ARTHRITIS IN A JAPANESE MULTICENTER REGISTRY2016
- Author(s)
  M. Hanabayashi, N. Takahashi, Y. Yokota, H. Miyake, T. Kojima, N. Ishiguro, on behalf of TBCR
- Organizer
  ＥＵＬＡＲ
- Place of Presentation
  London（ＵＫ）
- Year and Date
  2016-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] ADAM10 inhibitor suppresses chondrogenic dedifferentiation in bovine primary chondrocyte cells2016
- Author(s)
  祖父江康司　高橋伸典　小嶋俊久　石黒直樹
- Organizer
  62nd annual meeting of Orthopaedic Research Society
- Place of Presentation
  オーランド（米国）
- Year and Date
  2016-03-05
- Data Source
  KAKENHI-PROJECT-25462366
[Presentation] INFLUENCE OF ORAL PREDNISOLONE ON EFFECT OF DENOSUMAB ON OSTEOPOROSIS IN PATIENTS WITH JAPANESE RHEUMATOID ARTHRITIS; 12 MONTHS OF FOLLOW-UP A MULTICENTER REGISTRY STUDY2016
- Author(s)
  Y. Kanayama, Y. Hirano, N. Takahashi, S. Asai, N. Ishiguro, T. Kojima, on behalf of TBCR-BONE Study Group
- Organizer
  ＥＵＬＡＲ
- Place of Presentation
  London（ＵＫ）
- Year and Date
  2016-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] DAILY TERIPARATIDE TREATMENT AFTER BISPHOSPHONATE THERAPY IN OSTEOPOROSIS OF PATIENTS WITH RHEUMATOID ARTHRITIS2016
- Author(s)
  Y. Hirano, M. Isono, J. Fukui, J. Hasegawa, N. Ishiguro, T. Kojima
- Organizer
  ＥＵＬＡＲ
- Place of Presentation
  London（ＵＫ）
- Year and Date
  2016-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] EFFICACY OF INFLIXIMAB FOR SUPPRESSING RADIOGRAPHIC PROGRESSION OF CERVICAL LESIONS IN PATIENTS WITH RHEUMATOID ARTHRITIS COMPARISON WITH METHOTREXATE; TWO YEARS OF FOLLOW-UP A MULTICENTER REGISTRY STUDY2016
- Author(s)
  Y. Kanayama, T. Kojima, Y. Hirano, N. Takahashi, Y. Yabe, N. Ishiguro, on behalf of TBCR Study Group
- Organizer
  ＥＵＬＡＲ
- Place of Presentation
  London（ＵＫ）
- Year and Date
  2016-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] ADAM10阻害剤がウシ初代軟骨細胞において軟骨脱分化を抑制する2016
- Author(s)
  祖父江康司　高橋伸典　小嶋俊久　石黒直樹
- Organizer
  第29回軟骨代謝学会
- Place of Presentation
  広島大学広仁会館（広島県広島市）
- Year and Date
  2016-02-19
- Data Source
  KAKENHI-PROJECT-25462366
[Presentation] DRUG SURVIVAL OF GOLIMUMAB IN JAPANESE PATIENTS WITH RHEUMATOID ARTHRITIS IS INDEPENDENT OF METHOTREXATE AND PREDNISOLONE CONCOMITANCE: RESULTS FROM THE MULTICENTER BIOLOGICS REGISTRY2016
- Author(s)
  M. Hayashi, T. Kanamono, H. Matsubara, K. Kishimoto, N. Takahashi, T. Kojima, N. Ishiguro
- Organizer
  ＥＵＬＡＲ
- Place of Presentation
  London（ＵＫ）
- Year and Date
  2016-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] RETENTION RATE OF BIOLOGIC AGENTS AFTER REMISSION INDUCED WITH AND WITHOUT CONCOMITANT GLUCOCORTICOID TREATMENT IN PATIENTS WITH RHEUMATOID ARTHRITIS: A PROPENSITY SCORE MATCHED ANALYSIS2016
- Author(s)
  S. Asai, T. Kojima, N. Takahashi, K. Funahashi, N. Ishiguro, on behalf of TBCR Study Group
- Organizer
  ＥＵＬＡＲ
- Place of Presentation
  London（ＵＫ）
- Year and Date
  2016-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] 軟骨様細胞株（HCS2/8）において、カテプシンＫの発現はTRPV4刺激により亢進する2016
- Author(s)
  鈴木望人,高橋伸典,祖父江康司,小嶋俊久,石黒直樹
- Organizer
  第３回ベーシックリサーチカンファレンス
- Place of Presentation
  アキバホール（東京都千代田区）
- Year and Date
  2016-10-14
- Data Source
  KAKENHI-PROJECT-16K10897
[Presentation] 軟骨様細胞株(HCS-2/8)において,機械的ストレスはADAM10発現を介してCD44を断片化する2016
- Author(s)
  小早川知範　高橋伸典　小嶋俊久　石黒直樹
- Organizer
  第29回軟骨代謝学会
- Place of Presentation
  広島大学広仁会館（広島県広島市）
- Year and Date
  2016-02-19
- Data Source
  KAKENHI-PROJECT-25462366
[Presentation] DKK-1分子発現亢進による新規変形性関節症治療薬の開発－DKK-1promoter領域とpGL4.10をつないだconstract作成2016
- Author(s)
  西梅剛,高橋伸典,小嶋俊久,石黒直樹,大河原美静,大野欽司
- Organizer
  第３回ベーシックリサーチカンファレンス
- Place of Presentation
  アキバホール（東京都千代田区）
- Year and Date
  2016-10-14
- Data Source
  KAKENHI-PROJECT-16K10897
[Presentation] 周術期における生物学的製剤の使い方2016
- Author(s)
  小嶋俊久
- Organizer
  日本整形外科学会
- Place of Presentation
  パシフィコ横浜及びヨコハマグランドインターコンチネンタルホテル（神奈川県横浜市）
- Year and Date
  2016-05-12
- Invited
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] 関節リウマチ治療におけるJAK阻害薬2016
- Author(s)
  小嶋俊久
- Organizer
  日本関節病学会
- Place of Presentation
  別府国際コンベンションセンター（大分県別府市）
- Year and Date
  2016-11-11
- Invited
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] 現在そして今後のリウマチ治療を考える2016
- Author(s)
  小嶋俊久
- Organizer
  日本整形外科学会
- Place of Presentation
  パシフィコ横浜及びヨコハマグランドインターコンチネンタルホテル（神奈川県横浜市）
- Year and Date
  2016-05-12
- Invited
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] ＡＤＡＭ１０阻害剤がウシ初代軟骨細胞において軟骨脱分化を抑制する2016
- Author(s)
  祖父江康司,高橋伸典,小嶋俊久,石黒直樹
- Organizer
  第３回ベーシックリサーチカンファレンス
- Place of Presentation
  アキバホール（東京都千代田区）
- Year and Date
  2016-10-14
- Data Source
  KAKENHI-PROJECT-16K10897
[Presentation] The Predictors for Twelve Months Efficacy of Denosumab, an AntiRANKL Antibody, on Osteoporosis in Rheumatoid Arthritis Patients from Japanese Multicenter Study (TBCRBONE)2016
- Author(s)
  Y. Hirano, Y. Kanayama, M. Isono, N. Ishiguro, T. Kojima, on behalf of TBCR-BONE
- Organizer
  ＡＳＢＭＲ
- Place of Presentation
  Atlanta（ＵＳＡ）
- Year and Date
  2016-09-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] 名古屋大学医学部附属病院でのリウマチ治療におけるチーム医療2016
- Author(s)
  小嶋俊久
- Organizer
  中部リウマチ学会
- Place of Presentation
  ザ・グランユアーズフクイ（福井県福井市）
- Year and Date
  2016-09-02
- Invited
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] THE ASSOCIATION BETWEEN METHOTREXATE USE AND EFFECTS OF TREATMENT WITH A SECOND BIOLOGIC AGENT IN RHEUMATOID ARTHRITIS2016
- Author(s)
  Y. Ogawa, T. Kojima, N. Takahashi, K. Funahashi, N. Ishiguro
- Organizer
  ＥＵＬＡＲ
- Place of Presentation
  LonDon（ＵＫ）
- Year and Date
  2016-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] リウマチ性疾患の疼痛マネージメント2016
- Author(s)
  小嶋俊久
- Organizer
  日本臨床リウマチ学会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2016-10-29
- Invited
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] RELATIONSHIP BETWEEN BIOLOGICAL DMARDS TREATMENT AND COMPLICATIONS AFTER SURGICAL TREATMENT IN PATIENTS WITH RHEUMATOID ARTHRITIS2016
- Author(s)
  Y. Hirano, S. Hirabara, M. Isono, N. Ishiguro, T. Kojima.
- Organizer
  ＥＵＬＡＲ
- Place of Presentation
  London（ＵＫ）
- Year and Date
  2016-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] ＡＤＡＭ１０阻害剤がウシ初代軟骨細胞において軟骨脱分化を抑制する2016
- Author(s)
  祖父江康司,高橋伸典,小嶋俊久,石黒直樹
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K10897
[Presentation] SERO-POSITIVITY FOR RHEUMATOID FACTOR IS AN INDEPENDENT PREDICTOR FOR ACHIEVEMENT OF GOOD EULAR RESPONSE AT 24 WEEKS IN ACPA POSITIVE RHEUMATOID ARTHRITIS PATIENTS TREATED WITH ABATACEPT: RESULTS FROM JAPANESE MULTICENTER REGISTRY2016
- Author(s)
  N. Takahashi, T. Kojima, K. Funahashi, N. Ishiguro, on behalf of TBCR Study Group
- Organizer
  ＥＵＬＡＲ
- Place of Presentation
  London（ＵＫ）
- Year and Date
  2016-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] ADAM10 inhibitor suppresses chondrogenic dedifferentiation in bovine primary chondrocyte cells.2016
- Author(s)
  Sobue Y, Kojima T, Takahashi N, Ishiguro N
- Organizer
  Orthopaedic Research Society
- Place of Presentation
  オーランド,アメリカ
- Year and Date
  2016-03-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670660
[Presentation] Predictive Factors for Achieving Low Disease Activity at 52 Weeks after Switching from Tumor Necrosis Factor Inhibitors to Abatacept: Results from a Multicenter Observational Cohort Study of Japanese Patients2015
- Author(s)
  Kojima T , Takahashi N, Kaneko A, Kida D, Hirano Y, Fujibayashi T, Yabe Y, Takagi H, Oguchi T, Miyake H, Kato T, Watanabe T, Hayashi M, Shioura T, Kanayama Y, Funahashi K, Asai S, Yoshioka Y, Terabe K, Takemoto T, Asai N, Ishiguro N
- Organizer
  ACR 2015
- Place of Presentation
  San Francisco, CA, U.S.A.
- Year and Date
  2015-11-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] Relationship between index of activity speed (Time Up and Go test) and patient-reported outcome in patients with long-standing rheumatoid arthritis : multicenter prospective cohort study for evaluation of joint surgery on physical function2015
- Author(s)
  Kojima T, Ishikawa H, Nishida K, Hashimoto J, Miyahara H, Tanaka S, Haga N, Niki Y, Kojima M, Ishiguro N
- Organizer
  American College of Rheumatology
- Place of Presentation
  サンフランシスコ,アメリカ
- Year and Date
  2015-11-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670660
[Presentation] ADAM10 inhibitor suppresses chondrogenic dedifferentiation in bovine primary chondrocyte cells2015
- Author(s)
  祖父江康司　高橋伸典　小嶋俊久　石黒直樹
- Organizer
  第2回JCRベーシックリサーチカンファレンス
- Place of Presentation
  東京大学鉄門記念講堂（東京都文京区）
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-25462366
[Presentation] 関節リウマチの骨粗鬆症に対するデノスマブの早期効果 -多施設研究TBCR-BONEより-2015
- Author(s)
  平野裕司　金山康秀　浅井秀司　平原慎也　小嶋俊久　石黒直樹
- Organizer
  第59回日本リウマチ学会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] 軟骨様細胞株(HCS-2/8)において,機械的ストレスはADAM10発現を介してCD44を断片化する2015
- Author(s)
  小早川知範　高橋伸典　小嶋俊久　石黒直樹
- Organizer
  第30回日本整形外科学会基礎学術集会
- Place of Presentation
  富山国際会議場ＡＮＡクラウンプラザホテル富山市民プラザ（富山県富山市）
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-25462366
[Presentation] 関節リウマチの骨粗鬆症に対するデノスマブの短期臨床成績～TBCR-BONEより～Tsurumai Biologics Communication Registry-BONE (TBCR-BONE)2015
- Author(s)
  平野裕司金山康秀浅井秀司高橋伸典石黒直樹小嶋俊久
- Organizer
  第17回日本骨代謝学会
- Place of Presentation
  広島国際会議場（広島県広島市）
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] 軟骨様細胞株(HCS-2/8)において,機械的ストレスはADAM10発現を介してCD44を断片化する2015
- Author(s)
  小早川知範　高橋伸典　小嶋俊久　石黒直樹
- Organizer
  第2回JCRベーシックリサーチカンファレンス
- Place of Presentation
  東京大学鉄門記念講堂（東京都文京区）
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-25462366
[Presentation] Importance of both disease activity at 12 weeks and clinical response up to 12 weeks to predict achievement of low disease activity at 52 weeks during abatacept treatment in biologics-switching patients with rheumatoid arthritis: a multicenter observational cohort study in Japan2015
- Author(s)
  Kojima T , Takahashi N, Kaneko A, Kida D, Hirano Y, Fujibayashi T, Yabe Y, Takagi H, Oguchi T, Miyake H, Kato T, Watanabe T, Hayashi M, Shioura T, Kanayama Y, Funahashi K, Asai S, Yoshioka Y, Terabe K, Takemoto T, Asai N, Ishiguro N
- Organizer
  EULAR 2015
- Place of Presentation
  Rome, Italy
- Year and Date
  2015-06-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] Predictive Factors for Achieving Low Disease Activity at 52 Weeks after Switching from Tumor Necrosis Factor Inhibitors to Abatacept: Results from a Multicenter Observational Cohort Study of Japanese Patients.2015
- Author(s)
  Kojima T, Takahashi N, Kaneko A, Kida D, Hirano Y, Fujibayashi T, Yabe Y, Takagi H, Oguchi T, Miyake H, Kato T, Watanabe T, Hayashi M, Shioura T, Kanayama Y, Funahashi K, Asai S, Yoshioka Y, Terabe K, Takemoto T, Asai N, Ishiguro N
- Organizer
  American College of Rheumatology
- Place of Presentation
  サンフランシスコ,アメリカ
- Year and Date
  2015-11-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670660
[Presentation] THE SHORT-TERM EFFICACY OF DENOSUMAB IN OSTEOPOROSIS IN PATIENTS WITH RHEUMATOID ARTHRITIS FROM A JAPANESE MULTICENTER REGISTRY2015
- Author(s)
  Hirano Y, Kanayama Y, Hirabara S, Asai S, Takahashi N,　Ito T, Ishiguro N, Kojima T
- Organizer
  ASBMR2015 Annual Meeting
- Place of Presentation
  Seattle, WA, U.S.A.
- Year and Date
  2015-10-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] HYALURONAN INHIBITS TLR-4 DEPENDENT RANKL EXPRESSION IN HUMAN RHEUMATOID ARTHRITIS SYNOVIAL FIBROBLASTS2015
- Author(s)
  Watanabe T, Takahashi N, Ishiguro N, Kojima T
- Organizer
  ISHAS HA 2015 Conference
- Place of Presentation
  Firenze, Italy
- Year and Date
  2015-06-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] 関節リウマチにおける患者自身の全般評価の測定方法に関する検証2014
- Author(s)
  小嶋　雅代、小嶋　俊久、石黒　直樹、荒井　健介、辻村　尚子、藤田　ひとみ、岡本　尚子、細野　晃弘、鈴木　貞夫
- Organizer
  第24回日本疫学会学術総会
- Place of Presentation
  日立システムズホール仙台(仙台市）
- Data Source
  KAKENHI-PROJECT-21590708
[Presentation] 関節リウマチにおける患者自身の全般評価の測定方法に関する検証2014
- Author(s)
  小嶋雅代、小嶋俊久、石黒直樹、荒井健介、辻村尚子、藤田ひとみ、岡本尚子、細野晃弘、鈴木貞夫
- Organizer
  第24回日本疫学会学術総会
- Place of Presentation
  日立システムズホール仙台(仙台市)
- Year and Date
  2014-01-24
- Data Source
  KAKENHI-PROJECT-21590708
[Presentation] Lipophilic statins inhibit CD44 fragmentation in chondrocytes2014
- Author(s)
  寺部健哉、高橋伸典、小嶋俊久、石黒直樹
- Organizer
  Orthopedic research society annual meeting 2014
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-25462366
[Presentation] スタチンは軟骨様細胞におけるCD44の断片化を阻害する2014
- Author(s)
  寺部健哉、高橋伸典、小嶋俊久、石黒直樹
- Organizer
  第27回日本軟骨代謝学会
- Place of Presentation
  京都府医師会館、京都市
- Data Source
  KAKENHI-PROJECT-25462366
[Presentation] 運動器心身医療(ロコモサイコソマ) 関節リウマチ患者の痛みとメンタルヘルスに関する疫学的検討2013
- Author(s)
  小嶋　雅代
- Organizer
  第18回日本心療内科学会学術大会
- Place of Presentation
  愛知産業労働センター（名古屋市）
- Invited
- Data Source
  KAKENHI-PROJECT-21590708
[Presentation] 関節リウマチ患者のメンタルヘルスとコミュニケーション2013
- Author(s)
  小嶋雅代
- Organizer
  第35回東三河リウマチ研究会
- Place of Presentation
  ホテルアソシア豊橋(愛知県)
- Year and Date
  2013-08-10
- Invited
- Data Source
  KAKENHI-PROJECT-21590708
[Presentation] 関節リウマチ患者の痛みとメンタルヘルスに関する疫学的検討2013
- Author(s)
  小嶋雅代
- Organizer
  第18回日本心療内科学会学術総会
- Place of Presentation
  愛知県産業労働センター(名古屋市,招待シンポジウム)
- Year and Date
  2013-12-07
- Invited
- Data Source
  KAKENHI-PROJECT-21590708
[Presentation] 関節リウマチ患者のメンタルヘルスとコミュニケーション2013
- Author(s)
  小嶋　雅代
- Organizer
  第35回東三河リウマチ研究会
- Place of Presentation
  ホテルアソシア豊橋(愛知県）
- Invited
- Data Source
  KAKENHI-PROJECT-21590708
[Presentation] スタチンは軟骨様細胞におけるCD44の断片化を阻害する2013
- Author(s)
  寺部健哉、高橋伸典、小嶋俊久、石黒直樹
- Organizer
  第28回日本整形外科学会基礎学術集会
- Place of Presentation
  幕張メッセ国際会議場、千葉市
- Data Source
  KAKENHI-PROJECT-25462366
[Presentation] Lipophilic statins inhibit CD44 fragmentation in chondrocytes2013
- Author(s)
  寺部健哉、高橋伸典、小嶋俊久、石黒直樹
- Organizer
  International Society for Hyaluronan Sciences 9th International Conference
- Place of Presentation
  Oklahoma city, USA
- Data Source
  KAKENHI-PROJECT-25462366
[Presentation] 主観的幸福感の決定要因に関する疫学的検討2013
- Author(s)
  小嶋雅代, 細野晃弘, 荒井健介, 辻村尚子, 岡京子, 藤田ひとみ, 岡本尚子, 神谷真有美, 近藤文, 鈴木美奈, 柴田清, 鈴木貞夫
- Organizer
  第72回日本公衆衛生学会総会
- Place of Presentation
  三重県総合文化センター(三重県)
- Year and Date
  2013-10-24
- Data Source
  KAKENHI-PROJECT-21590708
[Presentation] 関節リウマチ寛解基準としてのPatient Reported Outcome－信頼性と妥当性の検証2013
- Author(s)
  小嶋　雅代
- Organizer
  第23回日本疫学会
- Place of Presentation
  大阪大学（大阪市）
- Data Source
  KAKENHI-PROJECT-21590708
[Presentation] リウマチ患者とリウマチ専門医を対象としたインタビューの比較分析2013
- Author(s)
  肥田武, 小嶋雅代, 鈴木貞夫:
- Organizer
  第59回東海公衆衛生学会学術大会
- Place of Presentation
  掛川市徳育保健センター(静岡県)
- Year and Date
  2013-07-20
- Data Source
  KAKENHI-PROJECT-21590708
[Presentation] 関節リウマチ寛解基準としてのPatient Reported Outcome―信頼性と妥当性の検証2013
- Author(s)
  小嶋雅代、小嶋俊久、石黒直樹、荒井健介、辻村尚子、藤田ひとみ、鈴木貞夫
- Organizer
  第23回日本疫学会学術総会
- Place of Presentation
  大阪大学(大阪市)
- Year and Date
  2013-01-24
- Data Source
  KAKENHI-PROJECT-21590708
[Presentation] 長期罹患者はリウマチ治療の変化をどのように感じているか　フォーカスグループによる質的研究2012
- Author(s)
  小嶋　雅代
- Organizer
  第58回東海公衆衛生学会
- Place of Presentation
  三重県立看護大学（津市）
- Data Source
  KAKENHI-PROJECT-21590708
[Presentation] リウマチ専門医の職務遂行プロセスの構造的理解医師に対するフォーカスグループの探索的分析から2012
- Author(s)
  肥田武, 小嶋雅代, 鈴木貞夫
- Organizer
  第58回東海公衆衛生学会学術大会
- Place of Presentation
  三重県立看護大学(三重県)
- Year and Date
  2012-07-21
- Data Source
  KAKENHI-PROJECT-21590708
[Presentation] 長期罹患者はリウマチ治療の変化をどのように感じているかフォーカスグループによる質的研究2012
- Author(s)
  小嶋雅代, 肥田武, 鈴木貞夫
- Organizer
  第58回東海公衆衛生学会学術大会
- Place of Presentation
  三重県立看護大学(三重県)
- Year and Date
  2012-07-21
- Data Source
  KAKENHI-PROJECT-21590708
[Presentation] 関節リウマチ患者の痛みとアレキシサイミア、ソーシャルサポートの関連2012
- Author(s)
  小嶋雅代、小嶋俊久、石黒直樹、荒井健介、辻村尚子、藤田ひとみ、鈴木貞夫
- Organizer
  第22回日本疫学会学術総会
- Place of Presentation
  学術総合センター(東京都)
- Year and Date
  2012-01-28
- Data Source
  KAKENHI-PROJECT-21590708
[Presentation] 関節リウマチ患者の身体的・心理的QOL-7年間の変化-2011
- Author(s)
  小嶋雅代, 小嶋俊久, 石黒直樹, 鈴木貞夫
- Organizer
  第21回日本疫学会学術総会
- Place of Presentation
  かでる2.7 (北海道立道民活動センター,札幌市)
- Year and Date
  2011-01-21
- Data Source
  KAKENHI-PROJECT-21590708
[Presentation] Alexithymia, Depression, Inflammation and Pain in Rheumatoid Arthritis Patients2011
- Author(s)
  Masayo Kojima, Toshihisa Kojima, Sadao Suzuki, Naoki Ishiguro
- Organizer
  The 21st World Congress of Psychosomatic Medicine
- Place of Presentation
  National Museum of Korea (Seoul, Korea)
- Year and Date
  2011-08-26
- Data Source
  KAKENHI-PROJECT-21590708
[Presentation] 女子大学生の飲酒行動と意識に関する調査2011
- Author(s)
  小嶋雅代, 上村義季, 永谷照男, 今枝奈保美, 辻村尚子, 荒井健介, 藤田ひとみ, 細野晃弘, 鈴木貞夫
- Organizer
  第70回日本公衆衛生学会総会
- Place of Presentation
  秋田アトリオン(秋田県)
- Year and Date
  2011-10-20
- Data Source
  KAKENHI-PROJECT-21590708
[Presentation] Alexithymia, Depression, Inflammation and Pain in Rheumatoid Arthritis Patients2011
- Author(s)
  Masayo Kojima, Toshihisa Kojima, Sadao Suzuki, Naoki Ishiguro
- Organizer
  The 21^<st> World Congress of Psychosomatic Medicine
- Place of Presentation
  National Museum of Korea (Seoul, Korea)
- Year and Date
  2011-08-26
- Data Source
  KAKENHI-PROJECT-21590708
[Presentation] Alexithymia as a Risk Factor for Long-term Mortality; an Epidemiological Study2011
- Author(s)
  Masayo Kojima
- Organizer
  The 21st World Congress of Psychosomatic Medicine
- Place of Presentation
  National Museum of Korea (Seoul, Korea)
- Year and Date
  2011-08-24
- Invited
- Data Source
  KAKENHI-PROJECT-21590708
[Presentation] 関節リウマチ患者の身体的・心理的QOL-7年間の変化-2011
- Author(s)
  小嶋雅代, 小嶋俊久, 石黒直樹, 鈴木貞夫
- Organizer
  第21回日本疫学会学術総会
- Place of Presentation
  かでる2.7(北海道立道民活動センター, 札幌市)
- Year and Date
  2011-01-21
- Data Source
  KAKENHI-PROJECT-21590708
[Presentation] Alexithymia as a Risk Factor for Long-term Mortality ; an Epidemiological Study2011
- Author(s)
  Masayo Kojima
- Organizer
  The 21^<st> World Congress of Psychosomatic Medicine
- Place of Presentation
  National Museum of Korea (Seoul, Korea)(招待講演)
- Year and Date
  2011-08-24
- Data Source
  KAKENHI-PROJECT-21590708
[Presentation] Factor structure of the Japanese SF-36 Health Survey in patients with chronic diseases2010
- Author(s)
  小嶋雅代, 小嶋俊久, 石黒直樹, 早野順一郎, 鈴木貞夫
- Organizer
  国際疫学会西太平洋地域学術会議兼第20回日本疫学会学術総会
- Place of Presentation
  埼玉
- Year and Date
  2010-01-09
- Data Source
  KAKENHI-PROJECT-21590708
[Presentation] Factor structure of the Japanese SF-36 Health Survey in patients with chronic diseases2010
- Author(s)
  小嶋雅代, 小嶋俊久, 石黒直樹, 早野順一郎, 鈴木貞夫
- Organizer
  国際疫学会西太平洋地域学術会議兼第20回日本疫学会学術総会
- Place of Presentation
  埼玉県立大学(埼玉県)
- Year and Date
  2010-01-09
- Data Source
  KAKENHI-PROJECT-21590708
[Presentation] 関節リウマチの骨粗鬆症に対するデノスマブの早期効果‐多施設研究TBCR-BONE より‐
- Author(s)
  平野　裕司, 金山　康秀, 浅井　秀司, 平原　慎也, 小嶋　俊久, 石黒　直樹
- Organizer
  第59回日本リウマチ学会
- Place of Presentation
  愛知県名古屋市：名古屋国際会議場
- Year and Date
  2015-04-23 – 2015-04-25
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] EFFICACY OF DAILY TERIPARATIDE FOR TWO YEARS ON OSTEOPOROSIS IN PATIENTS WITH RHEUMATOID ARTHRITIS - IS IT APPROPREATE TO COMBINE DAILY TERIPARATIDE AND BIOLOGICAL AGENTS?
- Author(s)
  Y. Hirano, Y. Oishi, G. Takemoto, T. Okada, T. Kojima, N. Ishiguro.
- Organizer
  EULAR
- Place of Presentation
  Paris,France
- Year and Date
  2014-06-11 – 2014-06-14
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] IMPORTANCE OF CONCOMITANT METHOTREXATE WITH TOCILIZUMAB AND ASSESSMENT OF STRUCTUAL DAMAGE FOR ACHIEVING BETTER CLINICAL OUTCOMES FOR RHEUMATOID ARTHRITIS PATIENTS WITH HIGH DISEASE ACTIVITY:AN OBSERVATIONAL COHORT STUDY
- Author(s)
  T. Kojima, N. Takahashi, K. Funahashi, S. Asai, S. Hirabara, M. Hanabayashi, Y. Yoshioka, Y. Yabe, N. Ishiguro, On behalf of Tsurumai Biologics Communication Registry (TBCR)
- Organizer
  EULAR
- Place of Presentation
  Paris,France
- Year and Date
  2014-06-11 – 2014-06-14
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] 関節軟骨細胞におけるＣＤ４４の断片化とその意義について
- Author(s)
  高橋伸典、寺部健哉、Cheryl B. Knudson、Warren Knudson、小嶋俊久、石黒直樹
- Organizer
  第46回日本結合組織学会学術大会
- Place of Presentation
  ウインクあいち（愛知県名古屋市）
- Year and Date
  2014-06-05 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-26670660
[Presentation] Improving of safety in treatment with biologics during first seven-years experience; Long-term results from observational cohort study of clinical paractice using multicenter registry in Japan
- Author(s)
  T. Kojima, N. Takahashi, K. Funahashi, Atsushi Kaneko, Yuji Hirano, Yuichiro Yabe,Yasuhide Kanayama,S. Asai, Y. Yoshioka, K. Terabe, T. Takemoto, N. Asai, N. Ishiguro
- Organizer
  American College of Rheumatology
- Place of Presentation
  Boston,USA
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26462290

1. ISHIGURO Naoki (20212871)

# of Collaborated Projects: 6 results

# of Collaborated Products: 66 results
2. Takahashi Nobunori (20570196)

# of Collaborated Projects: 4 results

# of Collaborated Products: 58 results
3. KITOH HIROSHI (40291174)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. KOJIMA Masayo (30326136)

# of Collaborated Projects: 3 results

# of Collaborated Products: 116 results
5. 舟橋康治 (80566977)

# of Collaborated Projects: 2 results

# of Collaborated Products: 23 results
6. 寺部健哉 (10816870)

# of Collaborated Projects: 2 results

# of Collaborated Products: 23 results
7. FURUKAWA Toshiaki (90275123)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
8. MISHIMA KENICHI (40646519)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OHNO KINJI (80397455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KITAKOJI Takahiko (10303637)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 酒井忠博 (60378198)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 浅井秀司 (00770893)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
13. 祖父江康司 (70790715)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 鈴木望人 (30826748)

# of Collaborated Projects: 1 results

# of Collaborated Products: 27 results
15. 永吉真子 (30728960)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 近藤克則 (20298558)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
17. 竹内研時 (10712680)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
18. 大塚礼 (00532243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
19. 斎藤民 (80323608)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 松井康素 (50501623)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
21. 安岡実佳子 (80874354)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
22. 渡邉良太 (50910410)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
23. YOSHIOKA Yutaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
24. HIRABARA shinya

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
25. HIRANO Yuji

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
26. HAYASHI Masatoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
27. YABE Yuichiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
28. OGUCHI Takeshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
29. FUJIBAYASHI Takayoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
30. TAKAGI Hideki

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
31. KANAYAMA Yasuhide

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
32. KAWAGUCHI Yohei

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
33. KANEKO Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
34. MURATA Chiyoe

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. OSAKA Ken

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 和栗祐子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
37. 浅井清文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 国生民

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
39. 加藤勝義

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
40. 長谷川好規

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 伊藤理

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 黒柳元

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kojima Toshihisa 小嶋 俊久

KOJIMA Toshihisa 小嶋 俊久

小嶋 俊久 コジマ トシヒサ

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Inhibition of cartilage destruction by controlling metabolic reprogramming - Aiming for novel rheumatoid arthritis treatment -Principal Investigator

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Inhibitory effects of combination therapy of denosumab, anti-RANKL antibody, and biological DMARD on bone and cartilage destruction in patients with rheumatoid arthritisPrincipal Investigator

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[Journal Article] Association between laughter, frailty, and depression in rheumatoid arthritis patients2024

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[Journal Article] Differences in prevalence of self‐reported oral hypofunction between older adult patients with rheumatoid arthritis and the general older population: A cross‐sectional study using propensity score matching2024

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[Journal Article] 「通いの場」を拠点とした地域在住高齢者の在宅フレイル予防プログラムの開発：みんなでHEPOP！2023

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Kojima Toshihisa 小嶋俊久

KOJIMA Toshihisa 小嶋俊久

小嶋俊久コジマトシヒサ