EBARA Shin 江原伸

Researcher Number	70379741
External Links
Affiliation (based on the past Project Information) *help	2012 – 2016: 岡山大学, 大学病院, 講師 2009: 岡山大学, 医学部・歯学部附属病院, 助教 2008: 岡山大学, 医学部・歯学部附属病院, 助手 2007: 岡山大, 医学部・歯学部附属病院, 助手 2004 – 2006: 岡山大学, 医学部・歯学部附属病院, 助手
Review Section/Research Field	Principal Investigator Urology Except Principal Investigator Urology
Keywords	Principal Investigator アポトーシス誘導 / 膀胱癌 / REIC/Dkk遺伝子 / 小胞体ストレス / P-glycoprotein / 抗癌剤耐性 / 癌 / マウス前立腺癌モデル / アポトーシス / REIC遺伝子 / ヒト前立腺癌株化細胞 … More Except Principal Investigator … More 遺伝子治療 / 前立腺癌 / REIC / JNK / Bax / DKK / NY-ESO-1 / 遺伝子導入 / Adenovirus / Prostate cancer / Renal cancer / Apoptosis / 膀胱癌 / 腎細胞癌 / 精巣腫瘍 / アデノウイルス / 前立腺がん / 腎がん / アポトーシス / dendritic cell / HV-tk / tumor associated antigen / adenovirus vector / gene therapy / prostate cancer / Interleukin-12 / 自殺遺伝子 / 樹状細胞 / HSV-tk / 腫瘍抗原 / アデノウイルスベクター / Wnt / 臨床 / バイオテクノロジー / 癌 / 遺伝子 / REIC/Dkk-3 / 癌増殖抑制 / IL-12 / 非ウイルスベクター / 高密度焦点超音波(HIFU) / インターロイキン12 / 高密度焦点超音波 / HSP70 / Dkk-3 / Dkk3 / P-glycoprotein / DKK3 / ストレス応答分子 / 薬剤耐性 / 遺伝子治療学 / 腫瘍学 / 生分解性ポリマー / 生分解 / テーラーメイド / ポリマー Less

制限増殖型アデノウィルスを用いた次世代遺伝子治療の基盤研究Principal Investigator
- Principal Investigator
  
  江原伸
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Okayama University
Suppression of oncogenic signaling by tumor suppressor REIC/Dkk-3
- Principal Investigator
  
  Kumon Hiromi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Urology
- Research Institution
  Okayama University
A new therapeutic medicine based on the investigation of membrane transporterPrincipal Investigator
- Principal Investigator
  
  EBARA Shin
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Okayama University
Novel approach with sonoporation in IL12 gene therapy for prostate cancer.
- Principal Investigator
  
  SAIKA Takashi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Okayama University
Fundamental research for new molecular mechanism of anticancer resistance in urogenital cancer
- Principal Investigator
  
  NASU Yasutomo
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Urology
- Research Institution
  Okayama University
生分解性ポリマーを用いたテーラーメイド型遺伝子治療用ベクターの開発研究
- Principal Investigator
  
  那須保友
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Urology
- Research Institution
  Okayama University
前立腺癌内分泌抵抗性の獲得機序におけるREIC遺伝子の機能解析と新規治療法の開発Principal Investigator
- Principal Investigator
  
  江原伸
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Urology
- Research Institution
  Okayama University
DEVELOPMENT OF TAILORED-MADE TYPE PROSTATE CANCER GENE THERAPY AIMING AT SYSTEMIC IMMUNE-ACTIVATION
- Principal Investigator
  
  KUMON Hiromi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Urology
- Research Institution
  Okayama University
Research on Functional Analysis and Clinical application of New Tumor-associated Gene (REIC) in Urogenital Cancer
- Principal Investigator
  
  NASU Yasutomo
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Urology
- Research Institution
  Okayama University

All 2016 2015 2009 2008 2007 2005 2004

All Journal Article

[Journal Article] The induction of antigen-specific CTL by in situ Ad-REIC gene therapy.2016
- Author(s)
  Ariyoshi Y, Watanabe M, Eikawa S, Yamazaki C, Sadahira T, Hirata T, Araki M, Ebara S, Nasu Y, Udono H, Kumon H.
- Journal Title
  
  Gene Ther.
  
  Volume: gt.2016.7 Issue: 5 Pages: 408-414
- DOI
  10.1038/gt.2016.7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26670237, KAKENHI-PROJECT-26290056, KAKENHI-PROJECT-15H04297, KAKENHI-PROJECT-26293352
[Journal Article] Adenovirus vector carrying REIC/DKK-3 gene: neoadjuvant intraprostatic injec- tion for high-risk localized prostate cancer undergoing radical prostatectomy.2016
- Author(s)
  Kumon H, Ariyoshi Y, Sasaki K, Sadahira T, Araki M, Ebara S, Yanai H, Watanabe M, Nasu Y
- Journal Title
  
  Cancer Gene Ther
  
  Volume: 23 Issue: 11 Pages: 400-409
- DOI
  10.1038/cgt.2016.53
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293352
[Journal Article] Ad-REIC Gene Therapy: Promising Results in a Patient with Metastatic CRPC Following Chemotherapy.2015
- Author(s)
  Hiromi Kumon, Katsumi Sasaki, Yuichi Ariyoshi, Takuya Sadahira, Shin Ebara, Takao Hiraki, Susumu Kanazawa, Hiroyuki Yanai, Masami Watanabe and Yasutomo Nasu.
- Journal Title
  
  Clinical Medicine Insights: Oncology
  
  Volume: 9 Pages: 31-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293352
[Journal Article] Feasibility of Neoadjuvant Ad-REIC Gene Therapy in Patients with High-Risk Localized Prostate Cancer Undergoing Radical Prostatectomy.2015
- Author(s)
  Kumon H, Sasaki K, Ariyoshi Y, Sadahira T, Araki M, Ebara S, Yanai H, Watanabe M, Nasu Y
- Journal Title
  
  Clin Transl Sci
  
  Volume: 8 Issue: 6 Pages: 837-840
- DOI
  10.1111/cts.12362
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293352
[Journal Article] Prospective longitudinal comparative study of health-related quality of life in patients treated with radical prostatectomy or permanent brachytherapy for prostate cancer.2009
- Author(s)
  Kobuke M, Saika T, Nakanishi Y, Ebara S, Manabe D, Uesugi T, Nose H, Arata R, Tsushima T, Nasu Y, Kumon H
- Journal Title
  
  Acta Med Okayama 63(3)
  
  Pages: 129-35
- NAID
  120002313130
- Data Source
  KAKENHI-PROJECT-19591851
[Journal Article] Iodine-125 seed impla(permanent brachytherapy) for clinically localized prostate cancer.2008
- Author(s)
  Ebara S, Katayama N, Tanimoto R, Edamura K, Nose H, Manabe D, Kobayashi T, Kobayashi Y, Kobuke M, Takemoto M, Saika T, Nasu Y, Kanazawa S, Kumon H
- Journal Title
  
  Acta Med Okayama 62(1)
  
  Pages: 9-13
- Data Source
  KAKENHI-PROJECT-19591851
[Journal Article] Initial report of hybrid radical prostatectomy for prostate cancer: reduced bleeding, clear vision, and secure surgical margins.2008
- Author(s)
  Saika T, Kobayashi Y, Watanabe T, Manabe D, Ebara S, Uehara S, Nasu Y, Kumon H
- Journal Title
  
  Acta Med Okayama 62(6)
  
  Pages: 379-84
- Data Source
  KAKENHI-PROJECT-19591851
[Journal Article] Adenovirus-mediated REIC/Dkk-3 gene transfer inhibits tumor growth and metastasis in an orthotopic prostate cancer model2007
- Author(s)
  Edamura K, Nasu Y, Takaishi M, Kobayashi T, Abarzua F, Sakaguchi M, Kashiwakura Y, Ebara S, Saika T, Watanabe M, Huh N.H, Kumon H
- Journal Title
  
  Cancer Gene Ther 14
  
  Pages: 765-772
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17659505
[Journal Article] Adenovirus-mediated REIC/Dkk-3 gene transfer inhibits tumor growth and metastasis in an orthotopic prostate cancer model2007
- Author(s)
  Edamura K, Nasu Y, Takaishi M, Kobayashi T, Abarzua F, Sakaguchi M, Kashiwakura Y, Ebara S, Saika T, Watanabe M, Huh N.H. Kumon H
- Journal Title
  
  Cancer Gene Ther 14
  
  Pages: 765-772
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390437
[Journal Article] Suicide gene therapy with adenoviral delivery of HSV-tK gene for patients with local recurrence of prostate cancer after hormonal therapy.2007
- Author(s)
  Nasu Y, Saika T, Ebara S, Kusaka N, Kaku H, Abarzua F, Manabe D, Thompson TC, Kumon H
- Journal Title
  
  Mol Ther 15(4)
  
  Pages: 834-40
- Data Source
  KAKENHI-PROJECT-19591851
[Journal Article] Suicide gene therapy with adenoviral delivery of HSV-tK gene for patients with local recurrence of prostate cancer after hormonal therapy2007
- Author(s)
  Nasu Y, Saika T, Ebara S, Kusaka N, Kaku H, Abarzua F, Manabe D, Thompson T.C, Kumon H
- Journal Title
  
  Mol Ther 15
  
  Pages: 834-840
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390437
[Journal Article] 岡山大学における前立腺癌遺伝子治療研究の現況と展望 -ベーシックリサーチからトランスレーショナルリサーチへ-2007
- Author(s)
  賀来春紀, 藤原俊義, 渡部昌実, 黄鵬, 陳潔, 谷本竜太フェルナンドアバルスア, 枝村康平真鍋大輔, 江原伸, 雑賀隆史那須保友, 公文裕巳
- Journal Title
  
  西日本泌尿器科 69
  
  Pages: 221-229
- NAID
  10019994587
- Data Source
  KAKENHI-PROJECT-17659505
[Journal Article] Adenovirus-mediated REIC/Dkk-3 gene transfer inhibits tumor growth and metastasis in an orthotopic prostate cancer model.2007
- Author(s)
  Edamura K, Nasu Y, Takaishi M, Kobayashi T, Abarzua F, Sakaguchi M, Kashiwakura Y, Ebara S, Saika T, Watanabe M, Huh NH, Kumon H
- Journal Title
  
  Cancer Gene Ther 14(9)
  
  Pages: 765-72
- Data Source
  KAKENHI-PROJECT-19591851
[Journal Article] Adenovirus-mediated REIC/Dkk-3 gene transfer inhibits tumo growth and metastasis in an orthotopic prostate cancer model2007
- Author(s)
  Edamura K, Nasu Y, Takaishi M, Kobayashi T, Abarzua F, Sakaguchi M, Kashiwakura Y, Ebara S, Saika T, Watanabe M, Huh NH, Kumon H
- Journal Title
  
  Cancer Gene Ther. 14
  
  Pages: 765-772
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390437
[Journal Article] Suicide gene therapy with adenoviral delivery of HSV-tK gene for patients withlocal recurrence of prostate cancer after hormonal therapy2007
- Author(s)
  Nasu Y, Saika T, Ebara S, Kusaka N, Kaku H, Abarzua F, Manabe D, Thompson T.C, Kumon H
- Journal Title
  
  Mol Ther. 15
  
  Pages: 834-840
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390437
[Journal Article] Suicide gene therapy with adenoviral delivery of HSV-tK gene for patients with local recurrence of prostate cancer after hormonal therapy2007
- Author(s)
  Nasu Y, Saika T, Ebara S, Kusaka N, Kaku H, Abarzua F, Manabe D, Thompson T.C, Kumon H
- Journal Title
  
  Mol Ther 15
  
  Pages: 834-840
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17659505
[Journal Article] Adenovirus-mediated overexpression of REIC/Dkk-3 selectively induces apoptosis in human prostate cancer cells through activation of c-Jun-NH2-Kinase.2005
- Author(s)
  Abarzua F., Sakaguchi M., Takaishi M., Nasu Y., Kurose K., Ebara S., Miyazaki M., Namba M., Kumon H., Huh Nam-ho.
- Journal Title
  
  Cancer Research 65(21)
  
  Pages: 9617-9622
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209052
[Journal Article] Interleukin-12による前立腺癌に対する新しい遺伝子治療の試み2004
- Author(s)
  那須保友, 江原伸, 公文裕巳
- Journal Title
  
  日本臨床 62(6)
  
  Pages: 1181-1191
- Data Source
  KAKENHI-PROJECT-15390491
[Journal Article] Interleukin-12による前立腺癌に対する新しい遺伝子治療の試み2004
- Author(s)
  那須保友, 江原伸, 公文裕巳
- Journal Title
  
  日本臨床 62(6)
  
  Pages: 1181-1191
- Data Source
  KAKENHI-PROJECT-15209052

1. NASU Yasutomo (20237572)

# of Collaborated Projects: 6 results

# of Collaborated Products: 15 results
2. Kumon Hiromi (30144760)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
3. SAIKA Takashi (10314676)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
4. KOBUKE Makoto (50452579)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. SAKAGUCHI Masakiyo (70379840)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. EDAMURA Kohei (90535816)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. WATANABE Masami (70444677)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NAKAYAMA Eiichi (60180428)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. YAMADA Masao (40166731)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. FUJIWARA Toshiyoshi (00304303)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MIYAZAKI Masahiro (90116509)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. HOH Nanho (70173573)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 定平卓也 (20733322)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 植木英雄 (90537218)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 賀来春紀 (60346426)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
16. 高本篤 (30716816)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 佐々木克己 (80467745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
18. 津島知靖 (20135990)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 鵜殿平一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

EBARA Shin 江原 伸

Research Projects

Research Products

Co-Researchers

制限増殖型アデノウィルスを用いた次世代遺伝子治療の基盤研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Suppression of oncogenic signaling by tumor suppressor REIC/Dkk-3

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A new therapeutic medicine based on the investigation of membrane transporterPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel approach with sonoporation in IL12 gene therapy for prostate cancer.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Fundamental research for new molecular mechanism of anticancer resistance in urogenital cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

生分解性ポリマーを用いたテーラーメイド型遺伝子治療用ベクターの開発研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

前立腺癌内分泌抵抗性の獲得機序におけるREIC遺伝子の機能解析と新規治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DEVELOPMENT OF TAILORED-MADE TYPE PROSTATE CANCER GENE THERAPY AIMING AT SYSTEMIC IMMUNE-ACTIVATION

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research on Functional Analysis and Clinical application of New Tumor-associated Gene (REIC) in Urogenital Cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The induction of antigen-specific CTL by in situ Ad-REIC gene therapy.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Adenovirus vector carrying REIC/DKK-3 gene: neoadjuvant intraprostatic injec- tion for high-risk localized prostate cancer undergoing radical prostatectomy.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ad-REIC Gene Therapy: Promising Results in a Patient with Metastatic CRPC Following Chemotherapy.2015

Author(s)

Journal Title

Data Source

[Journal Article] Feasibility of Neoadjuvant Ad-REIC Gene Therapy in Patients with High-Risk Localized Prostate Cancer Undergoing Radical Prostatectomy.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prospective longitudinal comparative study of health-related quality of life in patients treated with radical prostatectomy or permanent brachytherapy for prostate cancer.2009

Author(s)

Journal Title

EBARA Shin 江原伸