HARA Kenta 原賢太

Researcher Number	70397826
Other IDs
Affiliation (based on the past Project Information) *help	2011 – 2013: 神戸大学, 医学部附属病院, 講師 2008: Kobe University, 医学部附属病院, 助教 2008: Kobe University, 大学院医学研究科, 助教 2007: Kobe University, 医学系研究科, 特定助教 2007: Kobe University, Graduate School of Medicine, Professor … More 2007: Kobe University, Graduate School of Medicine, Assistant Professor 2005 – 2006: 神戸大学, 大学院・医学系研究科, COE研究員 2005 – 2006: 神戸大学, 大学院医学系研究科, COE研究員 Less
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Integrated Nutrition Science Except Principal Investigator Metabolomics / General internal medicine (including Psychosomatic medicine)
Keywords	Principal Investigator mTOR / 栄養センサー / Nutrition Sensor / Energy Metabolism / Signal Transduction / 癌 / 糖尿病 / エネルギー代謝 / シグナル伝達 / 代謝 … More / 分子栄養 / 分子栄養学 / 糖・エネルギー代謝 / 細胞内シグナル / 分子病態栄養学 … More Except Principal Investigator 1型糖尿病 / CD11c / 自己免疫 / 免疫寛容 / immune tolerance / regulatory T cell / cytokine / regulatory dendritic cell / bone marrow cell / autoimmunity / type 1 diabetes / 調節性T細胞 / サイトカイン / 制御性樹状細胞 / 骨髄細胞 / autoreactive T cell / insulin / Type 1 diabetes / 自己反応性T細胞 / インスリン / 樹状細胞 / 病原体感知センサー / １型糖尿病 Less

The role of dsRNA sensor in dendritic cells in a tolerized model of Type 1 diabetes
- Principal Investigator
  
  YASUDA HISAFUMI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Kobe University
栄養感知システムmTORシグナルの分子基盤の解明と分子栄養学への展開Principal Investigator
- Principal Investigator
  
  原賢太
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrated Nutrition Science
- Research Institution
  Kobe University
Regulation of mTOR-mediated nutrition sensing systemPrincipal Investigator
- Principal Investigator
  
  HARA Kenta
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kobe University
Prediction of human type 1 diabetes and preventive immune cell therapy using dendritic cells
- Principal Investigator
  
  YASUDA Hisafumi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kobe University
Physiological role and molecular mechanism of mTOR signaling as a sensor of nutritionPrincipal Investigator
- Principal Investigator
  
  HARA Kenta
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kobe University
Research of autoreactive Tcells to insulin as a major autoantigen in type 1 diabetes
- Principal Investigator
  
  MORIYAMA Hiroaki
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kobe University

All 2013 2012 2011 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book

[Book] 糖尿病学基礎と臨床「インスリンによる蛋白合成系とその調節」2007
- Author(s)
  原賢太、米澤一仁
- Publisher
  西村書店
- Data Source
  KAKENHI-PROJECT-19590308
[Book] 最新医学2005
- Author(s)
  原賢太
- Total Pages
  8
- Publisher
  最新医学社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590267
[Journal Article] Development of fulminant Type 1 diabetes with thrombocytopenia after influenza vaccination: a case report.2012
- Author(s)
  Yasuda H, Nagata M, Moriyama H, Kobayashi H, Akisaki T, Ueda H, Hara K, Yokono K.
- Journal Title
  
  Diabet Med.
  
  Volume: 29 Issue: 1 Pages: 88-89
- DOI
  10.1111/j.1464-5491.2011.03391.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590880
[Journal Article] Role of the mTOR complex 1 pathway in the in vivo maintenance of the intestinal mucosa by oral intake of amino acid.2012
- Author(s)
  Nakamura A, Hara K, Yamamoto K, Yasuda H, Moriyama H, Hirai M, Nagata M, Yokono K
- Journal Title
  
  Geriatr Gerontol Int.
  
  Volume: 12 Issue: 1 Pages: 131-139
- DOI
  10.1111/j.1447-0594.2011.00729.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590880
[Journal Article] A case of an elderly patient with slowly progressive type 1 diabetes who developed severe nonocclusive mesenteric ischemia without predisposing events2012
- Author(s)
  Hara K, Yasuda H, Arai T, Miyoshi S, Kubokawa O, Mori H, Akisaki T, Kido Y, Yokono K, Akita H
- Journal Title
  
  Intern Med
  
  Volume: 51(9) Pages: 1065-8
- NAID
  130002061802
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590880
[Journal Article] Development of fulminant Type 1 diabetes with thrombocytopenia after influenza vaccination : a case report2012
- Author(s)
  Yasuda H, Nagata M, Moriyama H, Kobayashi H, Akisaki T, Ueda H, Hara K, Yokono K
- Journal Title
  
  Diabet Med
  
  Volume: 29(1) Pages: 88-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590880
[Journal Article] ターゲット・オブ・mTOR、mTORC1とそのアミノ酸応答性の発見2012
- Author(s)
  原賢太
- Journal Title
  
  細胞工学
  
  Volume: Vol. 31 Pages: 1339-1340
- Data Source
  KAKENHI-PROJECT-23617012
[Journal Article] Cardiac mTOR protects the heart against ischemia-reperfusion injury.2012
- Author(s)
  Aoyagi T., Kusakari Y., Xiao C-Y, Inouye B. T., Takahashi M., Scherrer-Crosbie M., Rosenzweig A., Hara K., Matsui M.
- Journal Title
  
  Am J. Physiol. Heart Circ. Physiol.
  
  Volume: 303 Pages: 75-85
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23617012
[Journal Article] Role of the mTOR complex 1 pathway in the in vivo maintenance of the intestinal mucosa by oral intake of amino acids.2011
- Author(s)
  Nakamaura. A., Hara K., Yamamoto K., Yasuda H., Moriyama H., Hirai M., Nagata M., Yokono K.
- Journal Title
  
  Geriatr. Geriatol. Int.
  
  Volume: 12: Pages: 131-139
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23617012
[Journal Article] Acceleration of autoimmune diabetes in Rheb-congenic NOD mice with β-cell-specific mTORC1 activation.2011
- Author(s)
  Sasaki H, Yasuda H, Moriyama H, Nakamura A, Shimizu M, Arai T, Nagata M, Hara K, Yokono K.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 408 Pages: 306-311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23617012
[Journal Article] Acceleration of autoimmune diabetes in Rheb-congenic NOD mice with β-cell-specific mTORC1 activation2011
- Author(s)
  Sasaki, et al
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 408 Issue: 2 Pages: 306-311
- DOI
  10.1016/j.bbrc.2011.04.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890112, KAKENHI-PROJECT-23590880, KAKENHI-PROJECT-23890114
[Journal Article] Role of S6K1 in regulation of SREBP1c expression in the liver.2011
- Author(s)
  Li S., Ogawa W., Emi A., Hayashi K., Senga Y., Nomura K., Hara K., Yu D., Kasuga M.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 412 Pages: 197-202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23617012
[Journal Article] Acceleration of autoimmune diabetes in Rheb-congenic NOD mice withβ-cell-specific mTORC1 activation2011
- Author(s)
  Sasaki H, Yasuda H, Moriyama H, Nakamura A, Shimizu M, Arai T, Nagata M, Hara K, Yokono K
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 408(2) Pages: 306-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590880
[Journal Article] Upregulation of the mTOR Complex 1 Pathway by Rheb in Pancreatic β Cells Leads to Increased β Cell Mass and Prevention of Hyperglycemia.2009
- Author(s)
  Hamada S., Hara K., Hamada T., Yasuda H., Moriyama H., Nakayama R., Nagata M., Yokono K.
- Journal Title
  
  Diabetes. 58
  
  Pages: 1321-1332
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590308
[Journal Article] Ilow-dose warfarin functions as an immunomodulator to prevent cyclophosphamide-induced NOD diabetes.2008
- Author(s)
  Midori Kurohara
- Journal Title
  
  Kobe Journal of Medical Sciences 54
  
  Pages: 1-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590990
[Journal Article] Autoreactive T cell response in CD25 negative fraction of peripheral blood mononuclear cells from establishedtype 1 diabetes2008
- Author(s)
  Morivama, H, Kotani, R, Katsuta, A, Kameno, M, Arai, T, Okumachi, Y, Kishi, M, Yamada, K, Yasuda, H, Hara, K, Yokono, K, Nagata M
- Journal Title
  
  Ann N Y Acad Sci (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590932
[Journal Article] low-dose warfarin functions as an immunomodulator to prevent cyclophosphamide-induced NOD diabetes.2008
- Author(s)
  Midori Kurohara
- Journal Title
  
  Kobe Journal of Medical Sciences 54
- NAID
  110006648210
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590990
[Journal Article] Prevention of recurrent but not spontaneous autoimmune diabetes by transplanted NOD islets adenovirally transduced with immunomodulationg molecules.2008
- Author(s)
  Sakata M., Yasuda H., Moriyama K., Yamada K., Kotani R., Kurohara M., Okumachi Y., Kishi M., Arai T., Hara K., Hamada H., Yokono K., Nagata M.
- Journal Title
  
  Diabetes Res.Clin.Pract. 80
  
  Pages: 352-359
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590308
[Journal Article] One amino acid difference is critical for suppression for the development of experimental autoimmune diabetes (EAD) with intravenous injection of insulin:9-23 peptide.2008
- Author(s)
  Okumachi Y., Moriyama H., Kameno M., Arai T., Kishi Okumachi Y., Moriyama H., Kameno M., Arai T., Kishi M., Kurohara M., Yamada K., Yasuda H., Hara K., Yokono K. Nagata M.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 374
  
  Pages: 581-586
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590308
[Journal Article] low-dose warfarin functions as an immunomodulator to prevent cyclophosphamide-induced NOD diabetes2008
- Author(s)
  Midori, Kurohara., et. al.
- Journal Title
  
  Kobe Journal of Medical Sciences 54
- NAID
  110006648210
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590990
[Journal Article] Intravenous Aministration of Murine Proinsulin I or 2 Expressing Fiber-mutant Recombinant Adenovirous Vector Protects Diabetes in NOD mice2008
- Author(s)
  Yamada, K, Morivama, H, Okumachi, Y, Arai, T, Kameno, M, Kishi, M, Yasuda, H, Hara, K, Yokono, K, Naeata, M
- Journal Title
  
  A nn N Y Acad Sci (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590932
[Journal Article] Insulin as a T cell antigen in type 1 diabetes supported by the evidence from the insulin knouckout NOD mice.2007
- Author(s)
  Moriyama H., Nagata M., Arai T., Okumachi Y., Yamada K., Kotani R., Yasuda H., Hara K., Yokono K.
- Journal Title
  
  Diabetes Res.Clin.Pract. 77
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590308
[Journal Article] Immunological aspects of'fulminant type 1 diabetes2007
- Author(s)
  Nagata, M, Morivama, H, Kotani, R, Yasuda, H, Kishi, M, Kurohara, M., Hara, K, Yokono, K
- Journal Title
  
  Diabetes Res Clin Pract
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590932
[Journal Article] The Proline-Rich Akt Substrate of 40 kDa (PRAS40) is a physiological substrate of mTOR complex 12007
- Author(s)
  Oshiro N., Takahashi R., Yoshino K-I., Tanimura K., Nakashima A., Eguchi S., Miyamoto T., Hara K., Takehana K., Avruch J., Kikkawa U., Yonezawa K.
- Journal Title
  
  J. Biol. Chem 282
  
  Pages: 20329-20339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590308
[Journal Article] Modification of the Rb-binding domain of replication-competent adenoviral vector enhances cytotoxicity against human esophageal cancers via NF-kappaB activity2007
- Author(s)
  Yamada, K, Moriyama, H, Yasuda, H, Hara, IC, Maniwa, Y, Hamada, H, Yokono, K, Napata, M
- Journal Title
  
  Hum Gene Ther 18(5)
  
  Pages: 389-400
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590932
[Journal Article] Regulation of hypoxia-inducible factor 1 by glucose availability under hypoxic conditions.2007
- Author(s)
  Zhou J., Hara K., Inoue M., Hamada S., Yasuda H., Moriyama H., Endo H., Hirota K., Yonezawa K., Nagata M., Yokono K.
- Journal Title
  
  Kobe J. Med. Sci 53
  
  Pages: 283-296
- NAID
  110006646896
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590308
[Journal Article] Modification of the Rb-binding Domain of Replication- Competent Adenovirus Vector Enhances Cytotoxicity Against Human Esophageal Cancers via NF-kB Activity.2007
- Author(s)
  Yamada K., Moriyama H., Yasuda H., Hara K., Maniwa Y., Hamada H., Yokono K., Nagata M.
- Journal Title
  
  Human Gene Therapy 2007 18
  
  Pages: 389-400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590308
[Journal Article] Insulin as a T cell antigen in type 1 diabetes supported by the evidence from the insulin knockout NOD mice2007
- Author(s)
  Morivama, H, Nagata, M., Arai, T, Okumachi, Y, Yamada, K, Kotani, R, Yasuda, H, Hara, K, Yokono, K
- Journal Title
  
  Diabetes Res Clin Pract 23:77S
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590932
[Journal Article] Nutrient-dependent multimerization of the mammalian target of rapamycin through the N-terminal HEAT repeat region.2006
- Author(s)
  Takahara T.
- Journal Title
  
  J. Biol. Chem. 281
  
  Pages: 28605-28614
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590267
[Journal Article] mTORシグナルの分子メカニズムと生理的役割2005
- Author(s)
  原賢太
- Journal Title
  
  最新医学 60・(7)
  
  Pages: 1561-1568
- Data Source
  KAKENHI-PROJECT-17590267
[Journal Article] A possible association of ProI2Ala polymorphism in peroxisome proliferator-activated receptor gamma2 gene with obesity in native Javanese in Indonesia2005
- Author(s)
  Danawati, C. W., Nagata, M., Moriyama, H., Hara, K., Yasuda, H., Nakayama, M., Kotani, R., Yamada, K., Sakata, M., Kurohara, M., Wiyono, P., Asdie, H., Sakaue, M., Taniguchi, H., Yokono. K
- Journal Title
  
  Diabetes Metab Res 21
  
  Pages: 465-469
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590932
[Journal Article] Immunological Aspects of 'Fulminant Type 1 Diabetes.
- Author(s)
  Nagata M., Moriyama H., Kotani R., Yasuda H., Kishi M., Kurohara M., Hara K., Yokono K.
- Journal Title
  
  Diabetes Res. Clin. Pract.
  
  Pages: 0-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590308
[Presentation] １型糖尿病関連マウスにおけるpoly(I:C)投与による１型糖尿病発症の検討2013
- Author(s)
  清水まみ、安田尚史、勝田敦美、高橋和真、原賢太、永田正男、横野浩一
- Organizer
  第11回１型糖尿病研究会
- Place of Presentation
  軽井沢
- Data Source
  KAKENHI-PROJECT-23590880
[Presentation] FasL-Fasシグナルの1型糖尿病発症における役割の検討2013
- Author(s)
  安田尚史、勝田敦美、清水まみ、佐々木弘智、原賢太、秋田穂束、横野浩一
- Organizer
  第8回加齢医学研究会
- Place of Presentation
  名古屋
- Year and Date
  2013-01-19
- Data Source
  KAKENHI-PROJECT-23590880
[Presentation] 1型糖尿病関連マウスにおけるpoly(I : C)投与による1型糖尿病発症の検討2013
- Author(s)
  清水まみ、安田尚史、勝田敦美、高橋和真、原賢太、永田正男、横野浩一
- Organizer
  第11回1型糖尿病研究会
- Place of Presentation
  軽井沢
- Year and Date
  2013-10-26
- Data Source
  KAKENHI-PROJECT-23590880
[Presentation] Modified LDLがリガンドであるSR-Aの1型糖尿病発症への影響2012
- Author(s)
  清水まみ、安田尚史、中村晃、勝田敦美、佐々木弘智、荒井隆志、永田正男、原賢太、横野浩一
- Organizer
  第7回加齢医学研究会
- Place of Presentation
  名古屋
- Year and Date
  2012-01-21
- Data Source
  KAKENHI-PROJECT-23590880
[Presentation] NODマウスにおける1型糖尿病発症に関連するSR-Aの役割の検討2012
- Author(s)
  清水まみ、安田尚史、勝田敦美、中村晃、佐々木弘智、永田正男、原賢太、高橋和真、横野浩一
- Organizer
  第10回1型糖尿病研究会
- Place of Presentation
  唐津
- Year and Date
  2012-11-03
- Data Source
  KAKENHI-PROJECT-23590880
[Presentation] poly(I : C)投与SR-A KO NODマウスでの1型糖尿病発症の検討2012
- Author(s)
  清水まみ、安田尚史、中村晃、勝田敦美、佐々木弘智、荒井隆志、永田正男、原賢太、高橋和眞、横野浩一
- Organizer
  第55回日本糖尿病学会総会
- Place of Presentation
  横浜
- Year and Date
  2012-05-18
- Data Source
  KAKENHI-PROJECT-23590880
[Presentation] poly(I:C)投与SR-A KO NODマウスでの1型糖尿病発症の検討2012
- Author(s)
  清水まみ、安田尚史、中村　晃、勝田敦美、佐々木弘智、荒井隆志、永田正男、原　賢太、高橋和真、横野浩一
- Organizer
  第55回日本糖尿病学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590880
[Presentation] 膵β細胞特異的Rheb過剰発現NODマウスにおける1型糖尿病発症の検討2011
- Author(s)
  佐々木弘智、安田尚史、森山啓明、清水まみ、中村晃、荒井隆志、永田正男、原賢太、横野浩一
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23617012
[Presentation] 膵β細胞特異的Rheb過剰発現NODマウスにおける1型糖尿病発症の検討2011
- Author(s)
  佐々木弘智、安田尚史、森山啓明、清水まみ、中村晃、荒井隆志、永田正男、原賢太、横野浩一
- Organizer
  第54回日本糖尿病学会総会
- Place of Presentation
  札幌
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-23590880
[Presentation] 1型糖尿病発症におけるMSR-Aの役割の検討2011
- Author(s)
  清水まみ、安田尚史、森山啓明、中村晃、勝田敦美、花野智苗、佐々木弘智、荒井隆志、永田正男、原賢太、横野浩一
- Organizer
  第9回1型糖尿病研究会
- Place of Presentation
  大磯
- Year and Date
  2011-10-30
- Data Source
  KAKENHI-PROJECT-23590880
[Presentation] Upregulation of mTORC1 pathway by Rheb in pancreatic βcells leads to increased β cell mass and prevention of hyperglycemia. 68th Scientific Sessions2008
- Author(s)
  Kenta Hara, Suirin Hamada, Akira Nakamura, Hisafumi Yasuda, Hiroaki Moriyama, Masao Nagata, Koichi Yokono
- Organizer
  The American Diabetes Association
- Place of Presentation
  San Francisco, CA, USA
- Data Source
  KAKENHI-PROJECT-19590308
[Presentation] 膵β細胞におけるmTORシグナルの活性化と糖尿病発症の抑制2008
- Author(s)
  濱田水鈴、原賢太、中村晃、安田尚史、森山啓明、永田正男、横野浩一
- Organizer
  第50回日本老年医学会学術集会・総会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-19590308
[Presentation] Upregulatjon of the mTOR Complex 1 pathway by Rheb in pancrcalic β cells leads to increased β cell mass and prevention of hyperglycemia.2008
- Author(s)
  原賢太
- Organizer
  Scientific Sessions, American Diabetes Association
- Place of Presentation
  アメリカ合衆国サンフランシスコ
- Year and Date
  2008-06-06
- Data Source
  KAKENHI-PROJECT-19590308
[Presentation] mTORシグナルのRhebによる活性化は膵β細胞の成長を促し高血糖を抑制する2008
- Author(s)
  濱田水鈴、原賢太、中村晃、安田尚史、森山啓明、永田正男、横野浩一
- Organizer
  第51回日本糖尿病学会年次学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19590308
[Presentation] RhebによるmTORC1経路の活性化は膵β細胞の成長を促し高血糖を抑制する2007
- Author(s)
  原賢太、濱田水鈴、濱田猛、中村晃、安田尚史、森山啓明、永田正男、横野浩一
- Organizer
  第19回分子糖尿病学シンポジウム
- Place of Presentation
  神戸
- Year and Date
  2007-12-08
- Data Source
  KAKENHI-PROJECT-19590308
[Presentation] Autoreactive T cell responses in CD25 negative fraction of peripheral blood mononuclear cells from established type 1 diabetes2007
- Author(s)
  Morivama, H., Kotani, R., Kameno, M., Arai, T, Okumachi, Y., Kishi, M., Kurohara, M, Yasuda, H., Yamada, K., Yokono, K, Nagata M
- Organizer
  the 9th International Congress of the immunology of Diabetes Society and American Diabetes Association Research (IDS-9)
- Place of Presentation
  Miami, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590932
[Presentation] RhebによるmTORC1経路の活性化は膵β細胞の成長を促し高血糖を抑制する。2007
- Author(s)
  原賢太
- Organizer
  第19回分子糖尿病シンポジウム
- Place of Presentation
  神戸
- Year and Date
  2007-12-08
- Data Source
  KAKENHI-PROJECT-19590308
[Presentation] RhebによるmTORC1経路の活性化は膵β細胞の成長を促し高血糖を抑制する2007
- Author(s)
  原賢太
- Organizer
  第19回分子糖尿病シンポジウム
- Place of Presentation
  神戸
- Year and Date
  2007-12-08
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590990
[Presentation] Intervenous administration of murine proinsulinl or 2 expressing recombinant adenovirus vector protects from diabetes in NOD mice. Acta Diabetologia Vol. 44, S56 Poster presentation at the 9'" International Congress of the immunology of Diabetes Society and American Diabetes Association Research Symposium at Miami, November 20072007
- Author(s)
  Yamada, K., Morivama, H., Arai, T, Kameno, M., Okumachi, Y, Kishi, M., Kurohara, M, Yasuda, H., Yokono, K, Napata, M
- Organizer
  the 9°th International Congress of the immunology of Diabetes Society and American Diabetes Association Research (IDS-9)
- Place of Presentation
  Miami, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590932
[Presentation] 肥満糖尿病モデルマウスKK-AyマウスにおけるmTOR遺伝子ヘテロ欠損は肥満抵抗性をもたらす2007
- Author(s)
  原賢太
- Organizer
  第50日本糖尿病学会年次学術集会
- Place of Presentation
  仙台
- Year and Date
  2007-05-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590990
[Presentation] 肥満糖尿病モデルマウスKK-AyマウスにおけるmTOR遺伝子ヘテロ欠損は肥満抵抗性をもたらす。2007
- Author(s)
  原賢太
- Organizer
  第50回日本糖尿病学会年次学術集会
- Place of Presentation
  仙台
- Year and Date
  2007-05-25
- Data Source
  KAKENHI-PROJECT-19590308
[Presentation] One amino acid difference of insulin:9-23 peptides critically influence on the effect of deletional therapy for experimental autoimmune diabetes (EAD). Acta Diabetologia Vol. 44, S36 Poster presentation at the 9°i International Congress of the immunology of Diabetes Society and American Diabetes Association Research Symposium at Miami, November 20072007
- Author(s)
  Okumachi, Y., Moriyama, H., Kameno, M., Arai, T, Kishi, M., Kurohara, M, Yamada, K., Yasuda, H., Yokono, K., Nagata, M
- Organizer
  the 9th International Congress of the immunology of Diabetes Society and American Diabetes Association Research (IDS-9)
- Place of Presentation
  Miami, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590932
[Presentation] Intravenous Administration of Insulinl B9-23 Peptide Reduces T Cell Reactivity to Insulin and Protects Autoimmune Diabetes in Experimental Autoimmune Diabetes2006
- Author(s)
  Okumachi, Y, Morivama, H., Arai, T., Kishi, M., Kurohara, M., Yasuda, H., Kotani, R., Yasuda, H., Hara, K., Yokono, K., Nagata, M
- Organizer
  the 66th American Diabetes Association (ADA) meeting
- Place of Presentation
  Washington DC, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590932
[Presentation] Subcutaneous transplantation with Proinsulin2 expressing fibroblasts protects diabetes in NOD mice2006
- Author(s)
  Yamada, K., Moriyama, H., Okumachi, Y, Arai, T., Kishi, M., Kurohara, M., Yasuda, H., Hara, K, Yokono, K., Nagata, M
- Organizer
  the 66th American Diabetes Association (ADA) meeting
- Place of Presentation
  Washington DC, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590932
[Presentation] Pioglitazone投与によるNODマウスの塘尿病発症抑制2006
- Author(s)
  黒原みどり
- Organizer
  第49日本糖尿病学会年次学術集会
- Place of Presentation
  東京
- Year and Date
  2006-05-26
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590990

1. YOKONO Koichi (50144580)

# of Collaborated Projects: 6 results

# of Collaborated Products: 39 results
2. NAGATA Masao (70294220)

# of Collaborated Projects: 4 results

# of Collaborated Products: 19 results
3. MORIYAMA Hiroaki (70372646)

# of Collaborated Projects: 4 results

# of Collaborated Products: 15 results
4. YASUDA Hisafumi (50403233)

# of Collaborated Projects: 4 results

# of Collaborated Products: 28 results
5. 明嵜太一 (80467662)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results

HARA Kenta 原 賢太

Research Projects

Research Products

Co-Researchers

The role of dsRNA sensor in dendritic cells in a tolerized model of Type 1 diabetes

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栄養感知システムmTORシグナルの分子基盤の解明と分子栄養学への展開Principal Investigator

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Regulation of mTOR-mediated nutrition sensing systemPrincipal Investigator

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Prediction of human type 1 diabetes and preventive immune cell therapy using dendritic cells

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Physiological role and molecular mechanism of mTOR signaling as a sensor of nutritionPrincipal Investigator

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Research of autoreactive Tcells to insulin as a major autoantigen in type 1 diabetes

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[Book] 糖尿病学 基礎と臨床「インスリンによる蛋白合成系とその調節」2007

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[Book] 最新医学2005

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[Journal Article] Development of fulminant Type 1 diabetes with thrombocytopenia after influenza vaccination: a case report.2012

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DOI

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[Journal Article] Role of the mTOR complex 1 pathway in the in vivo maintenance of the intestinal mucosa by oral intake of amino acid.2012

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DOI

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[Journal Article] A case of an elderly patient with slowly progressive type 1 diabetes who developed severe nonocclusive mesenteric ischemia without predisposing events2012

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NAID

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[Journal Article] Development of fulminant Type 1 diabetes with thrombocytopenia after influenza vaccination : a case report2012

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[Journal Article] ターゲット・オブ・mTOR、mTORC1とそのアミノ酸応答性の発見2012

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[Journal Article] Cardiac mTOR protects the heart against ischemia-reperfusion injury.2012

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[Journal Article] Role of the mTOR complex 1 pathway in the in vivo maintenance of the intestinal mucosa by oral intake of amino acids.2011

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HARA Kenta 原賢太

[Book] 糖尿病学基礎と臨床「インスリンによる蛋白合成系とその調節」2007