HIKISHIMA Sadao 疋島貞雄

Researcher Number	70398816
Other IDs
Affiliation (based on the past Project Information) *help	2007 – 2011: Tokyo University of Pharmacy and Life Science, 薬学部, 助教 2006: 東京薬科大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Drug development chemistry Except Principal Investigator Drug development chemistry
Keywords	Principal Investigator 創薬化学 / 有機化学 / 薬学 / RNA干渉 / ラジカル反応 / ホスフィン酸 / ゲノム化学 / siRNA / ゲノム創薬 / Hussigen反応 … More / Sonogashira反応 / ジフルオロメチレンボスホン酸 / insituクリックケミストリー / Huisgen反応 / チミジンホスホリラーゼ / ジフルオロメチレンホスホン酸 / in situクリックケミストリー / 医薬分子設計 … More Except Principal Investigator PNP阻害剤 / スフィンゴミエリナーゼ / fragment-based drug design / ジフルオロホスホン酸 / ヌクレオチドアナログ / ジフルオロメチレンボスホン酸 / ホスフィン酸 / 速度論的光学分割 / ジペプチドイソスター / X線構造解析 / 遷移状態アナログ / ペプチドイソスター / Huisen反応 / Huisgen反応 / TP阻害剤 / Huisgen 反応 / クリック反応 / TP 阻害剤 / PNP 阻害剤 Less

Development of biologically active compounds based on features of phosphonyl and phosphinyl functional groups
- Principal Investigator
  
  YOKOMATSU Tsutomu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
Synthesis of siRNA molecules containing phosphinate type dinucleotide derivativesPrincipal Investigator
- Principal Investigator
  
  HIKISHIMA Sadao
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
Development of biologically active compounds based on features of fluoromethylene phosphonates
- Principal Investigator
  
  YOKOMATSU Tsutomu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
in situ クリックケミストリーを用いた二基質類縁型酵素阻害剤の創製Principal Investigator
- Principal Investigator
  
  疋島貞雄
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science

All 2010 2009 2008 2007

All Journal Article Presentation

[Journal Article] 9-Deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid are slow-binding picomolar inhibitors of trimeric purine nucleoside phosphorylase2010
- Author(s)
  K. Breer, L. Glavas-Obrovac, M. Suver, S. Hikishima, M. Hashimoto, T. Yokomatsu, B. Wielgus-Kutrowska, L. Magnowska, A. Bzowska
- Journal Title
  
  FEBS Journal
  
  Volume: 277 Pages: 1747-1760
- Data Source
  KAKENHI-PROJECT-21590126
[Journal Article] 1.45A resolution crystal structure of recombinat PNP in complex with a pM multisubstrate analogue inhibitor bearing one feature of posutulated transition state2010
- Author(s)
  G. Chojnowski, K. Breer, M. Narczyk, B. Wielgus-Kutrowska, H. Czapinska, M. Hashimoto, S. Hikishima, T. Yokomatsu, M. Bochtler, A. Girstun, K. Staro., A. Bzowska
- Journal Title
  
  Biochem. Biophys. Res. Comm
  
  Volume: 391 Pages: 703-708
- Data Source
  KAKENHI-PROJECT-21590126
[Journal Article] Structural-based design and synthesis of novel 9-deazaguanine derivatives having a phosphate mimic as multi-substrate analogue inhibitors for mammalian PNPs2010
- Author(s)
  S.Hikishima, T.Yokomatsu, 他
- Journal Title
  
  Bioorg.Med.Chem. 18
  
  Pages: 2275-2284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590126
[Journal Article] Structural-based design and synthesis of novel 9-deazaguanine derivatives having a phosphate mimic as multi-substrate analogue inhibitors for mammalian PNPs2010
- Author(s)
  S. Hikishima, M. Hashimoto, L. Magnowska, A. Bzowska and T. Yokomatsu
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 18 Pages: 2275-2284
- Data Source
  KAKENHI-PROJECT-21590126
[Journal Article] 9-Deazaguanine Derivatives Connected by a Linker to Difluoromethylene Phosphonic Acid Are Slow-binding Picomolar Inhibitors of Trimeric Purine Nucleoside Phosphorylase2010
- Author(s)
  K.Breer, L.Glavas-Obrovac, M.Suver, S.Hikishima, M.Hashimoto, T.Yokomatsu, B.Wielgus-Kutrowska, L.Magnowska, A.Bzowska
- Journal Title
  
  FEBS Journal
  
  Volume: 277 Pages: 1747-1760
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590126
[Journal Article] Structural-based Design and Synthesis of Novel 9-Deazaguanine Derivatives having a Phosphate Mimic as Multi-substrate Analogue Inhibitors for Mammalian PNPs2010
- Author(s)
  S.Hikishima, M.Hashimoto, L.Magnowska, A.Bzowska, T.Yokomatsu
- Journal Title
  
  Bioorg.Med.Chem.
  
  Volume: 18 Pages: 2275-2284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590126
[Journal Article] Antiproliferative avtivity of purine nucleoside phosphorylase multisubstrate analogu inhibitors containing difluoromethyl phosphonic acid against leukaemia and lymphoma cells2010
- Author(s)
  L. Glava.-Obrovac, M. Suver, S. Hikishima, M. Hashimoto, T. Yokomatsu, L. Magnowska, A. Bzowska
- Journal Title
  
  Chem. Bio. Drug. Des
  
  Volume: 75 Pages: 392-399
- Data Source
  KAKENHI-PROJECT-21590126
[Journal Article] Antiproliferative Activity of Purine Nucleoside Phosphorylase Multisubstrate Analogue Inhibitors containing Difluoromethyl Phosphonic Acid against Leukaemia and Lymphoma Cells2010
- Author(s)
  L.Glavas-Obrovac, M.Suver, S.Hikishima, M.Hashimoto, T.Yokomatsu, L.Magnowska, A.Bzowska
- Journal Title
  
  Chem.Bio.Drug.Des.
  
  Volume: 75 Pages: 399-399
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590126
[Journal Article] Overexpressed protein may act as mops removing their ligands from host cells : A case study of calf PNP2010
- Author(s)
  K. Breer, B. Wielgus-Kutrowska, A. Girstun, K. Staro., M. Hashimoto, S. Hikishima, T. Yokomatsu, A. Bzowska
- Journal Title
  
  Biochem. Biophys. Res. Comm
  
  Volume: 391 Pages: 1203-1209
- Data Source
  KAKENHI-PROJECT-21590126
[Journal Article] Diastereoselective synthesis of γ-amino-δ-hydroxy-α, α-difluorophosphonates : A vehiclefor for the structure-activity relationship of SMA-7, a potent sphingomyelinase inhibitor2009
- Author(s)
  T. Yamagishi, S. Muronoi, S. Hikishima, H. Shimeno, S. Soeda, and T. Yokomatsu
- Journal Title
  
  J. Org. Chem
  
  Volume: 74 Pages: 6350-6353
- Data Source
  KAKENHI-PROJECT-21590126
[Journal Article] Sphingomyelinease inhibition suggests a possible new strategy for the treatment of inflammatory bowel disease2008
- Author(s)
  S. Soeda, A. Sakata, T. Ochiai, K. Yasuda, Y. Kuramoto, H. Shimeno, A. Toda, R. Eyanagi, S. Hikishima, T. Yokomatsu, and S. Shibuya
- Journal Title
  
  Curr. Drug Therapy 3
  
  Pages: 218-225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590109
[Journal Article] Inhibition of lipopolysaccharide-induced Release of Interleukin-8 from Intestinal Epithelial Cells by SMA, a Novel Inhibitor of Sphingomyelinase and its Therapeutic Effect on Dextran Sulphate Sodium-induced Colitis in Mice2007
- Author(s)
  A. Sakata, K. Yasuda, T. Ochiai, H. Shimeno, S. Hikishima, T. Yokomatsu, S. Shibuya, and S. Soeda
- Journal Title
  
  Cell Immunology 245
  
  Pages: 24-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590109
[Journal Article] Inhibitory Properties of Nucleotides with Difluoromethy lenephosphonic Acid as a Phosphate Mimic versus Calf Spleen Purine Nucleoside Phosphorylase and Effect of These Analogues on the Viability of Human Blood Lymphocytes2007
- Author(s)
  L. Glavas-Obrovac, M. Suver ; S. Hikishima, T. Yokomatsu, and A. Bzowska
- Journal Title
  
  ucleosides, Nucleotides & Nucleic Acids 26
  
  Pages: 989-993
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590109
[Journal Article] Synthesis and biological evaluation of 9-deazaguanine derivatives connec-ted by a Linker to difluoromethylene phosphonic acid as multi-substrate analogue Inhibitors of PNP2007
- Author(s)
  S. Hikishima, M. Hashimoto, L. Magnowska, A. Bzowska, andT. Yokomatsu
- Journal Title
  
  Bioorganic Medicinal Chemistry Letters 17
  
  Pages: 4173-4177
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590109
[Journal Article] Synthesis and Biological Evalution of 9-Deazaguanine Derivatives connected by a Linker to Difluoromethylene phosphonic Acid as Multi-substrate Analogue Inhibitors of PNP2007
- Author(s)
  S. Hikishima, M. Hashimoto, L. Magnowska, A. Bzowska, and T. Yokomatsu
- Journal Title
  
  Bioorg. Med. Chem. Lett. 17
  
  Pages: 4173-4177
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590109
[Journal Article] Acid Sphingomyelinase Inhibition Suppresses Lipopolysaccharide-mediated Release of Inflammatory Cytokines from Macrophages and Protects against Disease Pathology in Dextran Sulphate Sodium-induced Colitis in Mices2007
- Author(s)
  A. Sakata, T. Ochiai, H. Shimeno, S. Hikishima, T. Yokomatsu, S. Shibuya, A. Toda, R. Eyanagi, and S. Soeda
- Journal Title
  
  Immunology 122
  
  Pages: 54-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590109
[Journal Article] Synthesis and biological evaluation of 9-deazagunine derivatives connected by a linker to difluoromethylene phoshponic acid as multi-substrate analogue inhibitors of PNP2007
- Author(s)
  S. Hikishima, M. Hashimoto, L. Magnowska, A. Bzowska, and T. Yokomatsu
- Journal Title
  
  Bioorganic Medicinal Chemistry Lettters 17
  
  Pages: 4273-4277
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790091
[Presentation] SBDDを用いた新規PNP阻害剤の創製研究2010
- Author(s)
  谷津智之, 疋島貞雄, Agnieszka Bzowska, 横松力
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21590126
[Presentation] ベンゼン環をスキャホールドとする二基質類縁型PNP阻害剤の創製研究2009
- Author(s)
  谷津智之, 疋島貞雄, 横松力
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] SMase阻害剤を指向した新規SMA-7類縁体の合成研究2009
- Author(s)
  野田祐介, 室野井真, 疋島貞雄, 山岸丈洋, 横松力
- Organizer
  第35回反応と合成の進歩シンポジウム
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-21590126
[Presentation] ベンゼン環をスキャホールドとする二基質類縁型PNP 阻害剤の創製研究2009
- Author(s)
  谷津智之, 疋島貞雄, 横松力
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] SBDDを用いた新規PNP阻害剤の創製研究2009
- Author(s)
  谷津智之, 疋島貞雄, Agnieszka Bzowska, 横松力
- Organizer
  第28回メディシナルケミストリーシンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21590126
[Presentation] SMase阻害剤を指向した機能性分子の創製研究2009
- Author(s)
  野田裕介, 疋島貞雄, 横松力
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] Huisgen反応を用いた新規二基質複合類縁型TP阻害剤の創製研究2008
- Author(s)
  橘真純, 疋島貞雄, 横松力
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-18790091
[Presentation] Huisgen反応を用いた新規2基質複合類縁型TP阻害剤の創製研究2008
- Author(s)
  橘真純, 疋島貞雄, 横松力
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] Thermodynamic studies of interactions of calf spleen PNP with acyclic phosphonate inhibitors2008
- Author(s)
  K. Breer, M. Hashimoto, S. Hikishima, A. Bzowska, 他
- Organizer
  Joint Symposium of the 18th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and the 35th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  京都
- Year and Date
  2008-09-08
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] 9-Deazaguanine derivatives : synthesis and inhibitory properties as multi-substrate analogue inhibitors of mammalian PNPs Joint Symposium of the 18th International Roundtable on Nucleosides2008
- Author(s)
  T. Yatsu, M. Hashimoto, S. Hikishima, L. Magnowska, A. Bzowska, and T. Yokomatsu
- Organizer
  Nucleotides and Nucleic Acids and the 35th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] Huisgen 反応を用いた新規2基質複合類縁型TP阻害剤の創製研究2008
- Author(s)
  橘真純, 疋島貞雄, 横松力
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] ホスホノジフルオロメチレン基を有するアジト誘導体とω-アルキニルピリミジン誘導体とのHuisgen反応2008
- Author(s)
  橘真純, 橋本真梨子, 疋島貞雄, 横松力
- Organizer
  第38回複素環化学討論会
- Place of Presentation
  福山
- Year and Date
  2008-11-21
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] リン酸等価体を有する新規2基質複合類縁型PNP阻害剤の創製研究2008
- Author(s)
  橋本真梨子, 疋島貞雄, 横松力
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] SMase阻害剤SMA-7誘導体の新規合成法の開発2008
- Author(s)
  室野井真, 山岸丈洋, 疋島貞雄, 横松力
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] Thermodynamic studies of interactions of calf spleen PNP with acyclic phosphonate inhibitors, Joint Symposium of the 18th International Roundtable on Nucleosides2008
- Author(s)
  K. Breer, B. Wielgus-Kutrowska, M. Hashimoto, S. Hikishima, T. Yokomatsu, R. H. Szczepanowski, M. Bochtler, A. Girstun, K. Staron, and A. Bzowska
- Organizer
  Nucleotides and Nucleic Acids and the 35th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] ホスホノジフルオロメチレン基を有するアジド誘導体と・-アルキニルピリミジン誘導体とのHuisgen反応2008
- Author(s)
  橘真純, 橋本真梨子, 疋島貞雄, 横松力
- Organizer
  第38回複素環化学討論会
- Place of Presentation
  福山
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] Synthetic Studies for Difluoromethylenephosphonate Analogues of MRS2216, a Selective P2Y_1 Receptor Antagonist2007
- Author(s)
  Sadao Hikishima, Arihiro Takatori, Atsushi Kojima, and Tsutomu Yokomatsu
- Organizer
  6^<th> AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  イスタンブール(トルコ)
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] 脂肪細胞でのPPAR・2発現におけるセラミドシグナルの役割2007
- Author(s)
  鍋山卓志, 藏元佑嘉子, 落合敬史, 林田諭, 添田秦司, 疋島貞雄, 横松力, 渋谷皓, 占野廣司
- Organizer
  第24回日本薬学会九州支部大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] PNP阻害剤を指向した新規ヌクレオチドアナログの設計と評価2007
- Author(s)
  疋島貞雄, 橋本真梨子, 添田秦司, 占野廣司, L. Magnowaka, A. Bzowska, 渋谷皓, 横松力
- Organizer
  日本ケミカルバイオロジー研究会第2回年会
- Place of Presentation
  京都
- Year and Date
  2007-05-09
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] 日本ケミカルバイオロジー研究会第2回年会2007
- Author(s)
  疋島貞雄, 橋本真梨子, 添田秦司, 占野廣司, Magnowaka Lucya, AgnieszkaBzowska, 渋谷皓, 横松力
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] Synthesis and evaluation of 9-deazaguanine derivatives as multi-substrate analogue inhibitors of PNP2007
- Author(s)
  M. Hashimoto, S. Hikishima, L. Magnowska, A. Bzowska, and T. Yokomatsu
- Organizer
  第5回国際核酸化学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2007-11-20
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] T細胞受容体を介した・産生におけるセラミドシグナルの役割2007
- Author(s)
  東みお, 落合敬史, 藏元佑嘉子, 添田秦司, 坂田晃, 疋島貞雄, 横松力, 渋谷皓, 占野廣司
- Organizer
  第24回日本薬学会九州支部大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] Synthesis and evaluation of 9-deazaguanine derivatives as multi-substrate analogue inhibitors of PNP2007
- Author(s)
  Mariko Hashimoto, Sadao Hikishima, Lucyna Magnowska, Angieszka Bzowska, and Tsutomu Yokomatsu
- Organizer
  Fifth Inetrnational Symposium on Nucleic Acids Chemistry
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] Synthesis and Biological Evaluation of 9-Deazaguanine Derivatives connected by a Linker to Difluoromethylene Phosphonic Acid2007
- Author(s)
  S. Hikishima, M. Hashimoto, L. Magnowska, A. Bzowska, and T. Yokomatsu
- Organizer
  第6回 AFMC国際メディシナルケミストリーシンポジウム
- Place of Presentation
  イスタンブール(トルコ)
- Year and Date
  2007-07-08
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] Synthesis and Biological Evaluation of 9-Deazaguanine Derivatives connected by a Linker to Difluoromethylene Phosphonic Acid2007
- Author(s)
  Sadao Hikishima, Mariko Hashimoto, Lucyna Magnowska, Agnieszka Bzowska, Tsutomu Yokomatsu
- Organizer
  6^<th> AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  イスタンブール(トルコ)
- Data Source
  KAKENHI-PROJECT-19590109

1. YOKOMATSU Tsutomu (70158369)

# of Collaborated Projects: 2 results

# of Collaborated Products: 39 results
2. YAMAGISHI Takehiro (90297606)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. ANGIESKA Bzowska

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. SOEDA Shinji (20078695)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
5. TACHIBANA Masumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. YATSU Tomoyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. NODA Yusuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

HIKISHIMA Sadao 疋島 貞雄

Research Projects

Research Products

Co-Researchers

Development of biologically active compounds based on features of phosphonyl and phosphinyl functional groups

Principal Investigator

Project Period (FY)

Research Category

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Research Institution

Synthesis of siRNA molecules containing phosphinate type dinucleotide derivativesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of biologically active compounds based on features of fluoromethylene phosphonates

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

in situ クリックケミストリーを用いた二基質類縁型酵素阻害剤の創製Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

[Journal Article] 9-Deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid are slow-binding picomolar inhibitors of trimeric purine nucleoside phosphorylase2010

Author(s)

Journal Title

Data Source

[Journal Article] 1.45A resolution crystal structure of recombinat PNP in complex with a pM multisubstrate analogue inhibitor bearing one feature of posutulated transition state2010

Author(s)

Journal Title

Data Source

[Journal Article] Structural-based design and synthesis of novel 9-deazaguanine derivatives having a phosphate mimic as multi-substrate analogue inhibitors for mammalian PNPs2010

Author(s)

Journal Title

Data Source

[Journal Article] Structural-based design and synthesis of novel 9-deazaguanine derivatives having a phosphate mimic as multi-substrate analogue inhibitors for mammalian PNPs2010

Author(s)

Journal Title

Data Source

[Journal Article] 9-Deazaguanine Derivatives Connected by a Linker to Difluoromethylene Phosphonic Acid Are Slow-binding Picomolar Inhibitors of Trimeric Purine Nucleoside Phosphorylase2010

Author(s)

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[Journal Article] Structural-based Design and Synthesis of Novel 9-Deazaguanine Derivatives having a Phosphate Mimic as Multi-substrate Analogue Inhibitors for Mammalian PNPs2010

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[Journal Article] Antiproliferative Activity of Purine Nucleoside Phosphorylase Multisubstrate Analogue Inhibitors containing Difluoromethyl Phosphonic Acid against Leukaemia and Lymphoma Cells2010

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[Journal Article] Overexpressed protein may act as mops removing their ligands from host cells : A case study of calf PNP2010

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[Journal Article] Diastereoselective synthesis of γ-amino-δ-hydroxy-α, α-difluorophosphonates : A vehiclefor for the structure-activity relationship of SMA-7, a potent sphingomyelinase inhibitor2009

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[Journal Article] Sphingomyelinease inhibition suggests a possible new strategy for the treatment of inflammatory bowel disease2008

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[Journal Article] Inhibition of lipopolysaccharide-induced Release of Interleukin-8 from Intestinal Epithelial Cells by SMA, a Novel Inhibitor of Sphingomyelinase and its Therapeutic Effect on Dextran Sulphate Sodium-induced Colitis in Mice2007

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[Journal Article] Inhibitory Properties of Nucleotides with Difluoromethy lenephosphonic Acid as a Phosphate Mimic versus Calf Spleen Purine Nucleoside Phosphorylase and Effect of These Analogues on the Viability of Human Blood Lymphocytes2007

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HIKISHIMA Sadao 疋島貞雄