Sunaga Noriaki 砂長則明

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SUNAGA NORIAKI 砂長則明

SUNAGA Noriaki 砂長則明

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Researcher Number	70400778
Other IDs
Affiliation (Current)	2025: 群馬大学, 医学部附属病院, 講師
Affiliation (based on the past Project Information) *help	2018 – 2023: 群馬大学, 医学部附属病院, 講師 2013 – 2017: 群馬大学, 医学部附属病院, 助教 2011 – 2012: 群馬大学, 医学(系)研究科(研究院), 助教 2010 – 2012: 群馬大学, 大学院・医学系研究科, 助教 2006 – 2008: 群馬大学, 医学部, 医員
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / Basic Section 53030:Respiratory medicine-related Except Principal Investigator Laboratory medicine / Thoracic surgery
Keywords	Principal Investigator 肺癌 / 分子標的治療 / 非小細胞肺癌 / 肺腺癌 / KRAS遺伝子変異 / Wntシグナル伝達経路 / Wnt経路 / KRAS変異 / Epiregulin / 予後不良因子 … More / EGFR遺伝子変異 / エピレギュリン / シグナル伝達 / 細胞増殖 / RNA干渉 / 変異型KRAS … More Except Principal Investigator 肺癌 / Smart Amplification Process / MDM2 / 禁煙外来 / Smart Amplification Process法 / SmartAmp法 / 発がん / MDM2 SNP309 / 喫煙 / SmartAmp 法 / SNP / 一塩基多型 / p53 / K-ras / EGFR / SMAP法 / 遺伝子 / 癌 Less

KRAS変異陽性肺癌の進展に関わる分子機構の解明と新規治療法の開発Principal Investigator
- Principal Investigator
  
  砂長則明
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Gunma University
Significance of LGR6 expression induced by Wnt pathway activation in lung cancerPrincipal Investigator
- Principal Investigator
  
  Sunaga Noriaki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Gunma University
Developing novel therapeutic strategies for non-small cell lung cancer with Wnt signaling alterationsPrincipal Investigator
- Principal Investigator
  
  Sunaga Noriaki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Gunma University
Oncogenic KRAS-mediated signal transduction and regulatory mechanisms for developing therapeutic strategies against lung adenocarcinomaPrincipal Investigator
- Principal Investigator
  
  Sunaga Noriaki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Gunma University
Significance of epiregulin expression induced by KRAS or EGFR mutation in non-small-cell lung cancerPrincipal Investigator
- Principal Investigator
  
  SUNAGA NORIAKI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Gunma University
Application of rapid gene analyzing method for susceptibility to cancer
- Principal Investigator
  
  SHIMIZU Kimihiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Gunma University
Clinical diagnosis and therapeutics for lung cancer by SMart Amplification Process(SMAP)
- Principal Investigator
  
  SHIMIZU Kimihiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  Gunma University
RNA干渉による変異型RASの発現抑制が肺癌の増殖やシグナル伝達系に与える影響Principal Investigator
- Principal Investigator
  
  砂長則明
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Gunma University

All 2021 2019 2018 2016 2013 2012 2008 2007 Other

All Journal Article Presentation

[Journal Article] Targeting Oncogenic KRAS in Non-Small-Cell Lung Cancer2021
- Author(s)
  Sunaga Noriaki、Miura Yosuke、Kasahara Norimitsu、Sakurai Reiko
- Journal Title
  
  Cancers
  
  Volume: 13 Issue: 23 Pages: 5956-5956
- DOI
  10.3390/cancers13235956
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08533
[Journal Article] Immune checkpoint inhibitors and driver oncogenes in non-small cell lung cancer.2019
- Author(s)
  Yosuke Miura, Norimitsu Kasahara, Noriaki Sunaga.
- Journal Title
  
  Transl Cancer Res
  
  Volume: 8 Issue: Suppl 6 Pages: S628-S632
- DOI
  10.21037/tcr.2019.10.08
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09644
[Journal Article] Oncogenic KRAS-induced epiregulin overexpression contributes to aggressive phenotype and is a promising therapeutic target in non-small-cell lung cancer.2012
- Author(s)
  Sunaga N, Kaira K, Imai H, Shimizu K, Nakano T, Shames DS, Girard L, Soh J, Sato M, Iwasaki Y, Ishizuka T, Gazdar AF, Minna JD, Mori M.
- Journal Title
  
  Oncogene
  
  Volume: 印刷中 Issue: 34 Pages: 4034-4042
- DOI
  10.1038/onc.2012.402
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591134, KAKENHI-PROJECT-23591145
[Journal Article] Usefulness of FDG-PET for early prediction of the response to gefitinib in non-small cell lung cancer2008
- Author(s)
  NORIAKI SUNAGA
- Journal Title
  
  Lung Cancer 59・2
  
  Pages: 203-210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790532
[Journal Article] Phase II prospective study of the efficacy of gefitinib for the treatment of stage III/IV non-small cell lung cancer with EGFR mutations, irrespective of previous chemotherapy2007
- Author(s)
  NORIAKI SUNAGA
- Journal Title
  
  Lung Cancer 56・3
  
  Pages: 383-389
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790532
[Presentation] 肺癌におけるWnt/β-catenin経路の恒常的な活性化によるTescalcinの過剰発現2019
- Author(s)
  砂長則明, 三浦陽介, 伊藤優志, 増田友美, 笠原礼光, 櫻井麗子, 久田剛志
- Organizer
  第60回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09644
[Presentation] LGR6 overexpression induced by constitutive activation of the Wnt signaling pathway in NSCLC cells2018
- Author(s)
  Noriaki Sunaga, Yosuke Miura, Kyoichi Kaira, Yusuke Tsukagoshi, Reiko Sakurai, Takeshi Hisada
- Organizer
  The 77th Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-17K09644
[Presentation] Oncogenic KRAS mutations induce PD-L1 overexpression through MAPK pathway activation in non-small cell lung cancer cells.2016
- Author(s)
  Yosuke Miura, Noriaki Sunaga, Kyoichi Kaira, Yusuke Tsukagoshi, Takashi Osaki, Reiko Sakurai, Takeshi Hisada, Luc Girard, John D. Minna, Masanobu Yamada.
- Organizer
  American Association for Cancer Research Annual Meeting 2016.
- Place of Presentation
  New Orleans, USA.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461181
[Presentation] Clinicopathological and biological significance of epiregulin expression in non-small cell lung cancer2013
- Author(s)
  砂長則明
- Organizer
  15th World Conference on Lung Cancer
- Place of Presentation
  Sydney, Australia
- Year and Date
  2013-10-28
- Data Source
  KAKENHI-PROJECT-23591134
[Presentation] Clinicopathological and biological significance of epiregulin expression in non-small cell lung cancer.2013
- Author(s)
  Sunaga N, Tomizawa Y, Shimizu K, Imai H, Takahashi G, Kakegawa S, Ohtaki Y, Nagashima T, Kawashima O, Shames DS, Girard L, Soh J, Sato M, Kaira K, Hisada T, Gazdar AF, Minna JD, Yamada M.
- Organizer
  15th World Conference on Lung Cancer
- Place of Presentation
  Sydney, Australia
- Data Source
  KAKENHI-PROJECT-23591134
[Presentation] 非小細胞肺癌におけるエピレグリンの臨床的及び分子生物学的意義2013
- Author(s)
  砂長則明
- Organizer
  第53回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2013-04-20
- Data Source
  KAKENHI-PROJECT-23591134
[Presentation] 非小細胞肺癌においてKRAS変異により誘導されるepiregulin過剰発現の意義2012
- Author(s)
  砂長則明
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PROJECT-23591134
[Presentation] 非小細胞肺癌においてKRAS変異により誘導されるepiregulin過剰発現の予後因子及び治療標的としての可能性2012
- Author(s)
  砂長則明
- Organizer
  第53回日本肺癌学会総会
- Place of Presentation
  岡山
- Year and Date
  2012-11-08
- Data Source
  KAKENHI-PROJECT-23591134
[Presentation] 非小細胞肺癌におけるepiregulin過剰発現の意義2012
- Author(s)
  砂長則明
- Organizer
  第52回日本呼吸器学会学術講演会
- Place of Presentation
  神戸
- Year and Date
  2012-04-22
- Data Source
  KAKENHI-PROJECT-23591134
[Presentation] 非小細胞肺癌におけるEpiregulin発現の意義
- Author(s)
  砂長則明、今井久雄、解良恭一、岩崎靖樹、久田剛志、石塚　全、土橋邦生、森　昌朋
- Organizer
  第52回日本呼吸器学会学術講演会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23591134
[Presentation] 非小細胞肺癌においてKRAS変異により誘導されるepiregulin過剰発現の予後因子及び治療標的としての可能性
- Author(s)
  砂長則明、解良恭一、今井久雄、清水公裕、中野哲宏、宗　淳一、佐藤光夫、岩崎靖樹、久田剛志、石塚　全、土橋邦生、森　昌朋
- Organizer
  第53回日本肺癌学会総会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-23591134
[Presentation] Biological and clinical significance of oncogenic KRAS-induced epiregulin overexpression in non-small cell lung cancer.
- Author(s)
  砂長則明、解良恭一、今井久雄、清水公裕、中野哲宏、岩崎靖樹、森　昌朋
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23591134

1. SHIMIZU Kimihiro (90375535)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. ALEXANDER Lezhava (40443048)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. SEIICHI Kakegawa (70447275)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. YANAGITANI Noriko (60400785)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MITANI Yasumasa (50435682)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KOGO Yasushi (20462682)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. USUI KENZGO (10525372)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TANAKA KAZUMI (30526843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MIURA YOSUKE

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Sunaga Noriaki 砂長 則明

SUNAGA NORIAKI 砂長 則明

SUNAGA Noriaki 砂長 則明

Research Projects

Research Products

Co-Researchers

KRAS変異陽性肺癌の進展に関わる分子機構の解明と新規治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Significance of LGR6 expression induced by Wnt pathway activation in lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Developing novel therapeutic strategies for non-small cell lung cancer with Wnt signaling alterationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Oncogenic KRAS-mediated signal transduction and regulatory mechanisms for developing therapeutic strategies against lung adenocarcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Significance of epiregulin expression induced by KRAS or EGFR mutation in non-small-cell lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Application of rapid gene analyzing method for susceptibility to cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clinical diagnosis and therapeutics for lung cancer by SMart Amplification Process(SMAP)

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

RNA干渉による変異型RASの発現抑制が肺癌の増殖やシグナル伝達系に与える影響Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Targeting Oncogenic KRAS in Non-Small-Cell Lung Cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Immune checkpoint inhibitors and driver oncogenes in non-small cell lung cancer.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Oncogenic KRAS-induced epiregulin overexpression contributes to aggressive phenotype and is a promising therapeutic target in non-small-cell lung cancer.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Usefulness of FDG-PET for early prediction of the response to gefitinib in non-small cell lung cancer2008

Author(s)

Journal Title

Data Source

[Journal Article] Phase II prospective study of the efficacy of gefitinib for the treatment of stage III/IV non-small cell lung cancer with EGFR mutations, irrespective of previous chemotherapy2007

Author(s)

Journal Title

Data Source

[Presentation] 肺癌におけるWnt/β-catenin経路の恒常的な活性化によるTescalcinの過剰発現2019

Author(s)

Organizer

Sunaga Noriaki 砂長則明

SUNAGA NORIAKI 砂長則明

SUNAGA Noriaki 砂長則明