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Yokohira Masanao  横平 政直

… Alternative Names

横平 政直  ヨコヒラ マサナオ

YOKOHIRA Masanao  横平 政直

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Researcher Number 70403780
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-8117-0495
Affiliation (Current) 2025: 香川大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2021 – 2023: 香川大学, 医学部, 教授
2006 – 2010: Kagawa University, 医学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 49030:Experimental pathology-related / Experimental pathology
Except Principal Investigator
Experimental pathology
Keywords
Principal Investigator
胸膜プラーク / マウス / 胸腔内投与 / TISMO / 腹腔内投与 / PFD / 二酸化チタン / 胸膜 / 針状粒子 / 中皮腫 … More / リスクアセスメント / 発がん / 炎症 / NNK / ラット / 肺 / ナノ粒子 / 気管内投与 … More
Except Principal Investigator
経気管内投与 / ラット / 中期発がん性試験法 / 肝発がん / 腫瘍 / 発がんリスク / ナノサイズ微粒子 / 二酸化チタン / 酸化銅 / GST-P positive foci / 経静脈投与 / 強制胃内投与 / 気管内投与 / ラット肝中期発癌試験 / ナノサイズ粒子 Less
  • Research Projects

    (3 results)
  • Research Products

    (42 results)
  • Co-Researchers

    (4 People)
  •  Establishment of animal model of pleural malignant mesothelioma for mechanism analysis and development of treatment methodsPrincipal Investigator

    • Principal Investigator
      Yokohira Masanao
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49030:Experimental pathology-related
    • Research Institution
      Kagawa University
  •  Carcinogenic risk assessment of nano-sized particles

    • Principal Investigator
      IMAIDA Katsumi
    • Project Period (FY)
      2007 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Kagawa University
  •  ナノサイズオーダー微粒子吸入による肺発がんリスクの検討Principal Investigator

    • Principal Investigator
      横平 政直
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Kagawa University

All 2011 2010 2009 2008 2007

All Journal Article Presentation

  • [Journal Article] Lack of promoting effects from physical pulmonary collapse in a female A/J mouse lung tumor initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone (NNK) with remarkable mesothelial cell reactions in the thoracic cavity by the polymer.2011

    • Author(s)
      Yokohira M, Hashimoto N, Yamakawa K, Saoo K, Kuno T, Imaida K.
    • Journal Title

      Exp.Toxicol.Pathol. 63

      Pages: 181-185

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Journal Article] Molecular analysis of carcinogen induced rodent lung tumors-Invovement of microRNA expression and Kras or EGFR mutation.2010

    • Author(s)
      Yamakawa K, Kuno T, Hashimoto N, Yokohira M, Suzuki S, Nakano Y, Saoo K, Imaida, K.
    • Journal Title

      Molecular Medicine Reports 3

      Pages: 141-147

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Journal Article] Risk analysis of environmental chemicals on lung carcinogenesis.2010

    • Author(s)
      Imaida K, Yokohira M, Hashimoto N, Kuno T.
    • Journal Title

      Asian Pacific J Cancer Prev 11

      Pages: 9-12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Journal Article] Potassium octatitanate fibers (TISMO) induce pleural mesothelial cell reactions with iron accumulation in female A/J mice2010

    • Author(s)
      Yokohira M, Hashimoto N, Imaida K, et al.
    • Journal Title

      Oncol.Lett. (in press)

    • Data Source
      KAKENHI-PROJECT-19590393
  • [Journal Article] Tumorigenesis of 2-Amino-3,8-dimethylimidazo[4,5-f]qu inoxaline (MeIQx), but not enhancing effects of concomitant high fat diet, on lung carcinogenesis in female A/J mice.2010

    • Author(s)
      Takeuchi H, Saoo K, Yamakawa K, Matsuda Y, Yokohira M, Zeng Y, Kuno T, Totsuka Y, Takahashi M, Wakabayashi K, Imaida K.
    • Journal Title

      Oncol.Lett. 1

      Pages: 137-142

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Journal Article] Different threshold levels for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MelQx) initiation of lung and colon carcinogenesis and the effects of an additional initiation by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mice.2010

    • Author(s)
      Suzuki S, Yokohira M, Hashimoto N, Saoo K, Matsuda Y, Yamakawa K, Nakano Y, Kuno T, Imaida K.
    • Journal Title

      Molecular Medicine Reports 3

      Pages: 301-307

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Journal Article] Potassium octatitanate fibers (TISMO) induce pleural mesothelial cell reactions with iron accumulation in female A/J mice.2010

    • Author(s)
      Yokohira M
    • Journal Title

      Oncol.Lett.

      Volume: 1巻 Pages: 589-594

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Journal Article] Lack of promoting effects from physical pulmonary collapse in a female A/J mouse lung tumor initiated with 4-(methylnitro-samino)-1-(3-pyridyl)-1-butanone (NNK) with remarkable mesothelial cell reactions in the thoracic cavity by the polymer2010

    • Author(s)
      Yokohira M, Hashimoto N, Imaida K, et al.
    • Journal Title

      Exp.Toxicol.Pathol. (in press)

    • Data Source
      KAKENHI-PROJECT-19590393
  • [Journal Article] Potassium octatitanate fibers (TISMO) induce pleural mesothelial cell reactions with iron accumulation in female A/J mice.2010

    • Author(s)
      Yokohira M, Hashimoto N, Yamakawa K, Suzuki S, Saoo K, Kuno T, Imaida K.
    • Journal Title

      Oncol.Lett. 1

      Pages: 273-278

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Journal Article] A lung carcinogenic bioassay of CuO and TiO2 nanoparticles with intratracheal instillation using F344 male rats2009

    • Author(s)
      Yokohira M, Hashimoto N, Imaida K, et al.
    • Journal Title

      J.Toxicol.Pathol. 22

      Pages: 71-78

    • NAID

      130000101848

    • Data Source
      KAKENHI-PROJECT-19590393
  • [Journal Article] Enhancing effects of a high fat diet on 2-amino-3,8-dimethylimidazo[4,5-f]qui noxaline (MeIQx) induced lung tumorigenesis in female A/J mice.2009

    • Author(s)
      Matsuda Y, Takeuchi H, Yokohira M, Saoo K, Hosokawa K, Yamakawa K, Zeng Y, Totsuka Y, Wakabayashi K, Imaida K.
    • Journal Title

      Molecular Medicine Reports 2

      Pages: 701-706

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Journal Article] Lack of modifying effects of intratracheal instillation of quartz or dextran sulfate sodium (DSS) in drinking water on lung tumor development initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female A/J mice2009

    • Author(s)
      Yokohira M.
    • Journal Title

      J.Toxicol.Pathol. 22

      Pages: 179-185

    • NAID

      10030978156

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Journal Article] An intratracheal instillation bioassay system for detection of lung toxicity due to fine particles in F344 rats.2009

    • Author(s)
      Yokohira M, Kuno T, Yamakawa K, Hashimoto N, Ninomiya F, Suzuki S, Saoo K, Imaida K.
    • Journal Title

      J.Toxicol.Pathol. 22

      Pages: 1-10

    • NAID

      10030977104

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Journal Article] Lack of modifying effects of intra-tracheal instillation of quartz or dextran sulfate sodium (DSS) in drinking water on lung tumor development initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-buta none (NNK) in female A/J mice2009

    • Author(s)
      Yokohira M, Hashimoto N, Imaida K, et al.
    • Journal Title

      J.Toxicol.Pathol. 22

      Pages: 179-185

    • Data Source
      KAKENHI-PROJECT-19590393
  • [Journal Article] Lack of modifying effects of intratracheal instillation of quartz or dextran sulfate sodium (DSS) in drinking water on lung tumor development initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female A/J mice.2009

    • Author(s)
      Yokohira M, Hashimoto N, Yamakawa K, Suzuki S, Saoo K, Kuno T, Imaida K.
    • Journal Title

      J.Toxicol.Pathol. 22

      Pages: 179-185

    • NAID

      10030978156

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Journal Article] carcinogenic bioassay of CuO and TiO2 nanoparticles with intratracheal instillation using F344 male rats.2009

    • Author(s)
      Yokohira M, Hashimoto N, Yamakawa K, Suzuki S, Saoo K, Kuno T, Imaida K. A lung
    • Journal Title

      J.Toxicol.Pathol. 22

      Pages: 71-78

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Journal Article] A lung carcinogenic bioassay of CuO and TiO2 nanoparticles with intratracheal instillation using F344 male rats2009

    • Author(s)
      Yokohira M.
    • Journal Title

      J.Toxicol.Pathol. 22

      Pages: 71-78

    • NAID

      130000101848

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Journal Article] An intratracheal instillation bioassay system for detection of lung toxicity due to fine particles in F344 rats2009

    • Author(s)
      Yokohira M, Kuno T, Imaida K, et al.
    • Journal Title

      J.Toxicol.Pathol. 22

      Pages: 1-10

    • NAID

      10030977104

    • Data Source
      KAKENHI-PROJECT-19590393
  • [Journal Article] Lung toxicity of 16 fine particles on intratracheal instillation in a bioassay model using F344 male rats.2008

    • Author(s)
      Yokohira M, Kuno T, Yamakawa K, Hosokawa K, Matsuda Y, Hashimoto N, Suzuki S, Saoo K, Imaida K.
    • Journal Title

      Toxicol.Pathol. 36

      Pages: 620-631

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Journal Article] Establishment of a bioassay model for lung cancer chemoprevention initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female A/J mice.2008

    • Author(s)
      Yokohira M, Takeuchi H, Saoo K, Matsuda Y, Yamakawa K, Hosokawa K, Kuno T, Imaida K.
    • Journal Title

      Exp.Toxicol.Pathol. 60

      Pages: 469-473

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Journal Article] Lack of modifying potential of 8-methoxypsoralen in the promotion or progression stages of lung carcinogenesis in A/J emale ice.2008

    • Author(s)
      Kuno T, Yokohira M, Matsuda Y, Suzuki S, Hashimoto N, Yamakawa K, Saoo K, Imaida K.
    • Journal Title

      Oncol.Rep. 20(4)

      Pages: 767-772

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Journal Article] Bioassay by intratracheal instillation for detection of lupg toxicity due to fine particles in F344 male rats2007

    • Author(s)
      Yokohira M, Takeuchi H, Yamakawa K, Saoo K, Matsuda Y, Zeng Y, Hosokawa K, Imaida K
    • Journal Title

      Exp Toxicol Pathol. 58

      Pages: 211-221

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Journal Article] CYP2A6 overexpression in human lung cancers corelates with a high malignant status2007

    • Author(s)
      Matsuda Y, Yamakawa K, Saoo K, Hosokawa K, Yokohira M, Kuno T, Iwai J, Shirai T, Obika K, Kamataki T, Imaida K
    • Journal Title

      Oncol Rep. 18

      Pages: 53-57

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Journal Article] Overexpression of CYP2A6 in Human Colorectal Tumors2007

    • Author(s)
      Matsuda Y, Saoo K, Yamakawa K, Yokohira M, Suzuki S, Kuno T, Kamataki T, Imaida K.
    • Journal Title

      Cancer Sci. 98

      Pages: 1582-1585

    • NAID

      10019997476

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Journal Article] 毒性病理学の最近の話題:経気道曝露による肺毒性-喫煙と大気汚染-2007

    • Author(s)
      今井田 克己、横平 政直
    • Journal Title

      病理と臨床 25

      Pages: 769-775

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Journal Article] Post-initiation chemopreventive effects of dietary bovine lactoferrin on4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesisin female A/J mice2007

    • Author(s)
      Matsuda Y, Saoo K, Hosokawa K, Yamakawa K, Yokohira M, Zeng Y, Takeuchi H, Imaida, K
    • Journal Title

      Cancer Letters 246

      Pages: 41-46

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Journal Article] Bioassay by intratracheal instillation for detection of lung toxicity due to fine particles in F344 male rats.2007

    • Author(s)
      Yokohira M, Takeuchi H, Yamakawa K, Saoo K, Matsuda Y, Zeng Y, Hosokawa K, Imaida K.
    • Journal Title

      Exp.Toxicol.Pathol. 58

      Pages: 211-221

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Journal Article] Detection of Carcinogenic and Modifying Potentials by Test Compounds Using a Mouse Lung Carcinogenesis Bioassay2007

    • Author(s)
      Imaida K, Yokohira Y, Kuno T
    • Journal Title

      J.Toxicol.Pathol. 20

      Pages: 117-123

    • NAID

      10025854280

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Journal Article] Detection of carcinogenic and modifying potentials by test compounds using amouse lung carcinogenesis bioassay.2007

    • Author(s)
      Imaida K, Yokohira Y, Kuno T.
    • Journal Title

      J.Toxicol.Pathol. 20

      Pages: 117-123

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Presentation] Comparison of nano- and micro-sized particles by three different route administrations using a medium-term liver carcinogenesis bioassay in F344 rats2009

    • Author(s)
      Hashimoto N, Yokohira M, Imaida K, et al.
    • Organizer
      American Association for Cancer Resaech 100^<th> Annual Meeting 2009
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Presentation] Comparison of nano- and micro-sized particles by three different route administrations using a medium-term liver carcinogenesis bioassay in F344 rats.2009

    • Author(s)
      橋本希, 横平正直, 今井田克己, et al.
    • Organizer
      American Association for Cancer Resaech 100^<th> Annual Meeting 2009.
    • Place of Presentation
      Colorado Convention Center,(米国)
    • Year and Date
      2009-04-19
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Presentation] 気管内投与によるCuOナノサイズ粒子の急性変化の検討-マイクロサイズ粒子との比較による-2009

    • Author(s)
      橋本希、横平正直、今井田克己, 他
    • Organizer
      第25回日本毒性病理学会
    • Place of Presentation
      浜松市
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Presentation] 気管内投与によるCuOナノサイズ粒子の急性変化の検討-マイクロサイズ粒子との比較による-2009

    • Author(s)
      橋本希, 横平正直, 今井田克己, 他
    • Organizer
      第25回日本毒性病理学会
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Presentation] Intratracheal instillation of CuO nanoparticles promotes liver carcinogenesis in F344 rats.2008

    • Author(s)
      橋本希, 横平正直, 今井田克己, et al.
    • Organizer
      67^<th> Annual Meeting of the Japanese Cancer Association.
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Presentation] Intratracheal instillation of CuO nanoparticles promotes liver carcinogenesis in F344 rats2008

    • Author(s)
      Hashimoto N, Yokohira M, Imaida K, et al.
    • Organizer
      67^<th> Annual Meeting of the Japanese Cancer Association
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Presentation] Potential of inhibitory effects by D-allose, a rare sugar, on liver carcinogenesis in a rat medium-term bioassay2007

    • Author(s)
      Yamakawa K, Yokohira M, Kuno T, Matsuda Y, Hashimoto N, Hosokawa K, Saoo K, Imaida K.
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2007-10-03
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Presentation] A study on the threshold for MeIQx carcinogenesis in lung using A/J mice2007

    • Author(s)
      Suzuki S, Yokohira M, Kuno T, Yamakawa K, Hosokawa K, Matsuda Y, Shiooka T, Imaida, K.
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2007-10-03
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Presentation] Detection of epidermal growth factor receptor(EGFR)gene mutation in rat lung tumors induced by X-ray irradiation2007

    • Author(s)
      Kitahashi T, Takahashi M, Tutsumi M, Kusuoka O, Yokohira M Imaida K, Takasuka N, Sugimura T, Wakabayashi K
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2007-10-03
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Presentation] Modulation effect of NNK-induced lung tumor by CYP2A inhibitor,8-MOP administered during promotion or progression phase2007

    • Author(s)
      Kuno T, Saoo K, Yokohira M, Yamakawa K, Hashimoto N, Hosokawa K. Matsuda Y. Imaida K
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2007-10-03
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Presentation] Short-term effect of various chemicals on NNK-induced tumorigenesis in A/J female mouse2007

    • Author(s)
      Matsuda Y, Yamakawa K, Saoo K, Yokohira M, Hosokawa K, Kuno T, Naito Z, Imaida, K.
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2007-10-03
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Presentation] Enzymatically modified isogercitrin and isoquercitorin, in a rat medium-term liver carcinogenesis bioassay2007

    • Author(s)
      Hosokawa K, Yokohira M, Yamakawa K, Saoo K, Matsuda Y, Suzuki S, Kuno T, Imaida K.
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2007-10-03
    • Data Source
      KAKENHI-PROJECT-19590393
  • [Presentation] Establishment of a bioassay for lung carcinogenesis due to fine particlesinstilled intratracheally in F344 rats2007

    • Author(s)
      Yokohira M, Kuno T, Saoo K, Yamakawa K, Suzuki S, Hosokawa K, Matsuda Y, Kinouchi S, Imaida K
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2007-10-03
    • Data Source
      KAKENHI-PROJECT-19590393
  • 1.  IMAIDA Katsumi (90160043)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 39 results
  • 2.  KUNO Toshiya (00345779)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 23 results
  • 3.  HASHIMOTO Nozomi (60448371)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 22 results
  • 4.  INOUE Tatsushi (80384593)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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