Yamashita Keishi 山下継史

… Alternative Names

山下継史ヤマシタケイシ

YAMASHITA Keishi 山下継史

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Researcher Number	70406932
Other IDs
Affiliation (Current)	2025: 北里大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 北里大学, 医学部, 教授 2018 – 2020: 北里大学, 医学部, 教授 2015: 北里大学, 医学部, 講師 2013: 北里大学, 医学部, 講師 2009 – 2011: Kitasato University, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Digestive surgery Except Principal Investigator Basic Section 55040:Respiratory surgery-related
Keywords	Principal Investigator 胃癌 / メチル化 / HOPX / CAF / 癌免疫 / 予後 / TME / 大腸癌 / COL8A1 / INHBA … More / SPARC / 線維芽細胞 / 癌間質 / 悪性予後 / 結腸癌 / CDO1遺伝子 / DNA marker / 腹水洗浄細胞診 / デジタルPCR / 微量癌細胞 / 腹水細胞診 / CDO1 / DNAマーカー / 腹膜播種 / Cyclin A1 / NMDAR2B / PGP9.5 / cancer / chemotherapy / apotosis / methylation / p53 / 新規治療 / ｐ53 / epigenetic / 臨床病理学的因子 / 定量 / ホメオボックス蛋白 / HOP / 患者選択 / 予後因子 / Stage I / 再発 … More Except Principal Investigator がん幹細胞 / 細胞株 / 癌抑制遺伝子 / 転移 / 微小乳頭型肺腺癌 / 肺癌 Less

Tumor microenvironment in colorectal cancer and exploration for therapeutic targetPrincipal Investigator
- Principal Investigator
  
  山下継史
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kitasato University
小球状構造を有する微小乳頭型肺腺癌における幹細胞性と悪性度の関連
- Principal Investigator
  
  佐藤之俊
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Kitasato University
Novel diagnosis assay to detect minimally residual disease of gastric cancer using epigenetic DNA markers.Principal Investigator
- Principal Investigator
  
  Yamashita Keishi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kitasato University
Relation of p53 pathway aberration to epigenetic treatment in human cancerPrincipal Investigator
- Principal Investigator
  
  Yamashita Keishi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kitasato University
Prediction of recurrence in stage I gastric cancerPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Keishi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kitasato University

All 2022 2021 2019 2015 2012 2011 2010 2009 2008

All Journal Article Presentation

[Journal Article] Prospective study to validate the clinical utility of DNA diagnosis of peritoneal fluid cytology test in gastric cancer2021
- Author(s)
  Harada Hiroki、Soeno Takafumi、Nishizawa Nobuyuki、Washio Marie、Sakuraya Mikiko、Ushiku Hideki、Niihara Masahiro、Hosoda Kei、Kumamoto Yusuke、Naitoh Takeshi、Sangai Takafumi、Hiki Naoki、Yamashita Keishi
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 4 Pages: 1644-1654
- DOI
  10.1111/cas.14850
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16422, KAKENHI-PROJECT-18K08656, KAKENHI-PROJECT-20K17630
[Journal Article] Exclusive Association of p53 Mutation with Super-High Methylation of Tumor Suppressor Genes in the p53 Pathway in a Unique Gastric Cancer Phenotype.2015
- Author(s)
  Waraya M, Yamashita K, Ema A, Katada N, Kikuchi S, Watanabe M
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 10 Pages: e0139902-e0139902
- DOI
  10.1371/journal.pone.0139902
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25462036
[Journal Article] Genomic and epigenetic profiles of gastric cancer : potential diagnostic and therapeutic applications.2011
- Author(s)
  Yamashita K, et al.
- Journal Title
  
  Surgery Today
  
  Volume: 41(1) Pages: 24-38
- NAID
  10027818359
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591711
[Journal Article] Therapeutic potential of PRL-3 targeting and clinical significance of PRL-3 genomic amplification in gastric cancer2011
- Author(s)
  Ooki A, Yamashita K, Kikuchi S, Sakuramoto S, Katada N, Waraya M, Kawamata H, Nishimiya H, Nakamura K, Watanabe M.
- Journal Title
  
  BMC Cancer
  
  Pages: 11-122
- Data Source
  KAKENHI-PROJECT-21591711
[Journal Article] Genomic and epigenetic profiles of gastric cancer : potential diagnostic and therapeutic applications2011
- Author(s)
  Yamashita K, Sakuramoto S, Watanabe M
- Journal Title
  
  Surg Today
  
  Volume: 41(1) Pages: 24-38
- NAID
  10027818359
- Data Source
  KAKENHI-PROJECT-21591711
[Journal Article] Potential utility of HOP homeobox gene promoter methylation as a marker of tumor aggressiveness in gastric cancer2010
- Author(s)
  大木、山下, ら
- Journal Title
  
  Oncogene
  
  Volume: 29 Pages: 3263-75
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591711
[Journal Article] Potential utility of HOP homeobox gene promoter methylation as a marker of tumor aggressiveness in gastric cancer2010
- Author(s)
  Ooki A, Yamashita K, Kikuchi S, Sakuramoto S, Katada N, Kokubo K, Kobayashi H, Kim MS, Sidransky D, Watanabe M.
- Journal Title
  
  Oncogene
  
  Volume: 29(22) Pages: 3263-75
- Data Source
  KAKENHI-PROJECT-21591711
[Journal Article] Phosphatase of regenerating liver-3 as a convergent therapeutic target for lymph node metastasis in esophageal squamous cell carcinoma2010
- Author(s)
  Ooki A, Yamashita K, Kikuchi S, Sakuramoto S, Katada N, Watanabe M.
- Journal Title
  
  Int J Cancer
  
  Volume: 127(3) Pages: 543-54
- Data Source
  KAKENHI-PROJECT-21591711
[Journal Article] Phosphatase of regenerating liver-3 as a prognostic biomarker in histologically node-negative gastric cancer2009
- Author(s)
  Ooki A, Yamashita K, Kikuchi S, Sakuramoto S, Katada N, Watanabe M.
- Journal Title
  
  Oncol Rep
  
  Volume: 21(6) Pages: 1467-75
- Data Source
  KAKENHI-PROJECT-21591711
[Journal Article] Phosphatase of regenerating liver-3 as a prognostic biomarker in histologically node-negative gastric cancer2009
- Author(s)
  大木、山下, ら
- Journal Title
  
  Oncol Rep
  
  Volume: 21 Pages: 1467-75
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591711
[Journal Article] Liver metastasis of colorectal cancer by protein-tyrosine phosphatase type 4A, 3(PRL-3) is mediated through lymph node metastasis and elevated serum tumor markers such as CEA and CA19-92008
- Author(s)
  Hatate K, Yamashita K, Hirai K, Kumamoto H, Sato T, Ozawa H, Nakamura T, Onozato W, Kokuba Y, Ihara A, Watanabe M.
- Journal Title
  
  Oncol Rep
  
  Volume: 20(4) Pages: 737-43
- Data Source
  KAKENHI-PROJECT-21591711
[Presentation] Comprehensive exploration of novel biomarkers in micropapillary lung adenocarcinoma using expression microarray analysis.2022
- Author(s)
  松尾由紀子、園田大、三窪将史、山下継史、佐藤之俊
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K08983
[Presentation] CDO1遺伝子メチル化を利用した新規診断法　胃癌DNA腹水洗浄細胞診の確立2019
- Author(s)
  原田宏輝、山下継史
- Organizer
  日本分子腫瘍マーカー研究会
- Data Source
  KAKENHI-PROJECT-18K08656
[Presentation] 消化器外科領域に応用可能な分子レベルの技術開発　がん特異的DNA markersを用いた"病理学的不可視"がんの可視化による革新的がん医療開発2019
- Author(s)
  山下継史
- Organizer
  日本癌学会総会
- Data Source
  KAKENHI-PROJECT-18K08656
[Presentation] Epigenetic silencing of cancer-specific methylation may converge on therapeutic targets on human cancers2012
- Author(s)
  Yamashita K, Kim MS, Ooki A, Kato H, Waraya M, Kawamata H, Watanabe M, Sidransky D.
- Organizer
  AACR Annual Meeting(Minisymposium)
- Place of Presentation
  Chicago, IL, USA
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-21591711
[Presentation] Clinical significance of PRL-3 genomic amplification/expression profiles and preclinical study of PRL-3 inhibitor in human GI cancers2012
- Author(s)
  Yamashita K, Ooki A, Nakayama K, Hatate K, Hirai K, and Watanabe M.
- Organizer
  ASCO Annual Meeting 2012
- Place of Presentation
  Chicago, IL, USA
- Year and Date
  2012-06-01
- Data Source
  KAKENHI-PROJECT-21591711
[Presentation] 大腸癌における癌抑制遺伝子HOPXの同定とAP-1(c-Fos/c-Jun)経路のクロスリンクと細胞死2012
- Author(s)
  山下継史, ら
- Organizer
  第112回日本外科学会
- Place of Presentation
  幕張
- Year and Date
  2012-04-14
- Data Source
  KAKENHI-PROJECT-21591711
[Presentation] 大腸癌および膵臓癌における癌抑制遺伝子(homeobox only protein) HOPXの役割2011
- Author(s)
  藁谷美奈、山下継史、渡邊昌彦
- Organizer
  第20回日本がん転移学会総会
- Place of Presentation
  浜松
- Year and Date
  2011-06-30
- Data Source
  KAKENHI-PROJECT-21591711
[Presentation] HOPX tumor suppressive pathways may be epigenetically controlled in colorectal cancer2011
- Author(s)
  Yamashita K, Ooki A, Katoh H, Waraya M, and Watanabe M.
- Organizer
  ISOBM, Firrenze
- Place of Presentation
  Italy
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-21591711
[Presentation] Cancer-specific epigenetic alteration of HOPX in human cancer, and its functional relevance in carcinogenesis(Workshop)2011
- Author(s)
  Yamashita K, Ooki A, Katoh H, Waraya M, and Watanabe M.
- Organizer
  8th ISMRC
- Place of Presentation
  Osaka
- Year and Date
  2011-09-21
- Data Source
  KAKENHI-PROJECT-21591711
[Presentation] Tumor Suppressive Role of HOPX Gene in Pancreatic Carcinogenesis2011
- Author(s)
  Waraya M, Yamashita K, Watanabe M
- Organizer
  ISOBM, Firrenze
- Place of Presentation
  Italy
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-21591711
[Presentation] Causative of tumor progression for suppressor gene HOP epigenetically regulated in gastric cancer2010
- Author(s)
  山下継史, ら
- Organizer
  日本癌学会(English Workshop)
- Place of Presentation
  リーガロイヤルホテル大阪(大阪府)
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-21591711
[Presentation] HOPX is epigenetically and cancerspecifically silenced tumor suppressor gene candidates in colorectal cancer2010
- Author(s)
  Kato H, Yamashita K., Ooki A, Waraya M, Kawamata H, Nakamura K, Nishimiya H and Watanabe M
- Organizer
  第69回日本癌学会総会(International session, English Workshop)
- Place of Presentation
  大阪
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21591711
[Presentation] Causative role of tumor suppressor gene HOP epigenetically regulated in gastric cancer(International session, English Workshop)2010
- Author(s)
  Yamashita K., Ooki A, Kato H, Waraya M, Kawamata H, Nakamura K, Nishimiya H, Okubo H, and Watanabe M.
- Organizer
  第69回日本癌学会総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21591711
[Presentation] 消化器癌診断・治療におけるHOP/OB1/NECC1プロモーターDNAメチレーションの臨床的有用性2009
- Author(s)
  山下継史、大木暁、加藤弘、藁谷美奈、河又寛、渡邊昌彦
- Organizer
  第29回日本分子腫瘍マーカー研究会
- Place of Presentation
  横浜
- Year and Date
  2009-09-30
- Data Source
  KAKENHI-PROJECT-21591711
[Presentation] Selection of High Risk Patients in Advanced Gastric Cancer(AGC)(Paper Free)2009
- Author(s)
  Yamashita K., Sakuramoto S, Kikuchi S, Katada N, and Watanabe M.
- Organizer
  2009 International Surgical Week
- Place of Presentation
  Adelade, Australia
- Data Source
  KAKENHI-PROJECT-21591711

1. 佐藤之俊 (90321637)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 三窪将史 (90723940)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 原田宏輝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamashita Keishi 山下 継史

山下 継史 ヤマシタ ケイシ

YAMASHITA Keishi 山下 継史

Research Projects

Research Products

Co-Researchers

Tumor microenvironment in colorectal cancer and exploration for therapeutic targetPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

小球状構造を有する微小乳頭型肺腺癌における幹細胞性と悪性度の関連

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel diagnosis assay to detect minimally residual disease of gastric cancer using epigenetic DNA markers.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Relation of p53 pathway aberration to epigenetic treatment in human cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Prediction of recurrence in stage I gastric cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Prospective study to validate the clinical utility of DNA diagnosis of peritoneal fluid cytology test in gastric cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exclusive Association of p53 Mutation with Super-High Methylation of Tumor Suppressor Genes in the p53 Pathway in a Unique Gastric Cancer Phenotype.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genomic and epigenetic profiles of gastric cancer : potential diagnostic and therapeutic applications.2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Therapeutic potential of PRL-3 targeting and clinical significance of PRL-3 genomic amplification in gastric cancer2011

Author(s)

Journal Title

Data Source

[Journal Article] Genomic and epigenetic profiles of gastric cancer : potential diagnostic and therapeutic applications2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Potential utility of HOP homeobox gene promoter methylation as a marker of tumor aggressiveness in gastric cancer2010

Author(s)

Journal Title

Data Source

[Journal Article] Potential utility of HOP homeobox gene promoter methylation as a marker of tumor aggressiveness in gastric cancer2010

Author(s)

Journal Title

Data Source

[Journal Article] Phosphatase of regenerating liver-3 as a convergent therapeutic target for lymph node metastasis in esophageal squamous cell carcinoma2010

Author(s)

Journal Title

Data Source

[Journal Article] Phosphatase of regenerating liver-3 as a prognostic biomarker in histologically node-negative gastric cancer2009

Author(s)

Journal Title

Data Source

[Journal Article] Phosphatase of regenerating liver-3 as a prognostic biomarker in histologically node-negative gastric cancer2009

Author(s)

Journal Title

Data Source

Yamashita Keishi 山下継史

山下継史ヤマシタケイシ

YAMASHITA Keishi 山下継史

[Presentation] CDO1遺伝子メチル化を利用した新規診断法　胃癌DNA腹水洗浄細胞診の確立2019

[Presentation] 消化器外科領域に応用可能な分子レベルの技術開発　がん特異的DNA markersを用いた"病理学的不可視"がんの可視化による革新的がん医療開発2019