Manya Keiko 萬谷啓子

… Alternative Names

MANYA KEIKO 萬谷啓子

Keiko Manya 萬谷啓子

MANYA Keiko 萬谷啓子

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Researcher Number	70415496
Other IDs
Affiliation (Current)	2025: 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員
Affiliation (based on the past Project Information) *help	2025: 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 2019 – 2023: 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 2015: 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 2009 – 2011: Tokyo Metropolitan Institute of Gerontology, 東京都健康長寿医療センター研究所, 研究員 2008: Tokyo Metropolitan Institute of Gerontology, 東京都老人総合研究所, 研究員 2007: Tokyo Metropolitan Institute of Gerontology, 東京都老人総合研究所, 研究員
Review Section/Research Field	Principal Investigator Basic Section 52010:General internal medicine-related / Pathological medical chemistry Except Principal Investigator Biological pharmacy
Keywords	Principal Investigator 糖鎖 / APP / アルツハイマー病 / 糖転移酵素 / 老化 / 肺 / bisecting GlcNAc / 0-マンノース型糖鎖 / O-マンノース型糖鎖 / α-ジストログリカン … More / POMT / ο-マンノース型糖鎖 / 筋ジストロフィー / 筋ジストロフィー症 … More Except Principal Investigator 脳の発生 / 糖転移酵素 / O-マンノース / 筋ジストロフィー / 糖鎖 Less

老化組織で増加するパウチマンノース型糖鎖の生理機能と発現機構の解明Principal Investigator
- Principal Investigator
  
  萬谷啓子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Tokyo Metropolitan Institute for Geriatrics and Gerontology
オミクス解析による肺の老化メカニズムの解明Principal Investigator
- Principal Investigator
  
  萬谷啓子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
Regulatory Mechanism of APP Metabolism by O-GlycosylationPrincipal Investigator
- Principal Investigator
  
  MANYA KEIKO
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
Molecular basis of regulation of nerve function by glycosylation
- Principal Investigator
  
  Endo Tamao
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
Regulation of APP metabolism by glycosyltransferasePrincipal Investigator
- Principal Investigator
  
  MANYA Keiko
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
Glycosyltransferases on muscular dystrophy and their breakdown.Principal Investigator
- Principal Investigator
  
  MANYA Keiko
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
  Tokyo Metropolitan Institute of Gerontology

[Book] 腎臓内科第18巻第1号2023
- Author(s)
  赤阪（萬谷）啓子、萬谷博
- Total Pages
  8
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-22K07436
[Book] 食品免疫学事典2021
- Author(s)
  日本食品免疫学会（赤阪啓子、萬谷　博ほか）
- Total Pages
  492
- Publisher
  朝倉書店
- ISBN
  9784254431261
- Data Source
  KAKENHI-PROJECT-19K07883
[Book] Vitamins and Hormones.2016
- Author(s)
  Akasaka-Manya, K., Manya, H., and Endo, T.
- Total Pages
  18
- Publisher
  Academic Press/Elsevier
- Data Source
  KAKENHI-PROJECT-25293016
[Book] Sugar chains2015
- Author(s)
  Manya, H., Endo, T.
- Total Pages
  288
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-25293016
[Book] Handbook of Glycosyl transferases and related genes. (Part3-16 : POMT1,2)2014
- Author(s)
  Manya, H., Endo, T.
- Total Pages
  7
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-25293016
[Book] Handbook of Glycosyltransferases and related genes2014
- Author(s)
  Manya, H., Endo, T.
- Total Pages
  1707
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-25293016
[Book] Handbook of Glycosyltransferases and related genes. (Part4-30 : POMGnT1)2014
- Author(s)
  Manya, H., Endo, T.
- Total Pages
  6
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-25293016
[Journal Article] Enzyme assay of protein O-mannosyltransferase (POMT1/2)2023
- Author(s)
  Keiko Akasaka-Manya, Hiroshi Manya and Tamao Endo
- Journal Title
  
  Glycoscience Protocols (GlycoPODv2)
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07436
[Journal Article] Enzyme assay of protein O-linked-mannose β1,2- N-acetylglucosaminyltransferase 1 and protein O-linked-mannose β1,4-N-acetylglucosaminyltransferase 2 (POMGNT1/2)2023
- Author(s)
  Keiko Akasaka-Manya, Hiroshi Manya and Tamao Endo
- Journal Title
  
  Glycoscience Protocols (GlycoPODv2)
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07436
[Journal Article] Decreased ADAM17 expression in the lungs of α-Klotho reduced mouse.2020
- Author(s)
  Keiko Akasaka-Manya, Hiroshi Manya, Satomi Nadanaka, Hiroshi Kitagawa , Yoshitaka Kondo, Akihito Ishigami and Tamao Endo
- Journal Title
  
  J. Biochem.
  
  Volume: - Issue: 5 Pages: 483-493
- DOI
  10.1093/jb/mvz113
- NAID
  40022226796
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07353, KAKENHI-PROJECT-19K07883, KAKENHI-PROJECT-20H03386, KAKENHI-PROJECT-19H04043
[Journal Article] The Role of APP O-Glycosylation in Alzheimer’s Disease2020
- Author(s)
  Akasaka-Manya Keiko、Manya Hiroshi
- Journal Title
  
  Biomolecules
  
  Volume: 10 Issue: 11 Pages: 1569-1569
- DOI
  10.3390/biom10111569
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07883
[Journal Article] Lactone-Driven Ester-to-Amide Derivatization for Sialic Acid Linkage-Specific Alkylamidation2020
- Author(s)
  Jun-Ichi Furukawa 1, Hisatoshi Hanamatsu 2, Takashi Nishikaze 3, Hiroshi Manya 4, Nobuaki Miura 5, Hirokazu Yagi 6, Ikuko Yokota 1, Keiko Akasaka-Manya 4, Tamao Endo 4, Motoi Kanagawa 7 8, Norimasa Iwasaki 1, Koichi Tanaka 3
- Journal Title
  
  Anal Chem .
  
  Volume: 3 Issue: 21 Pages: 14383-14392
- DOI
  10.1021/acs.analchem.0c02209
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08443, KAKENHI-PROJECT-19K07883, KAKENHI-PROJECT-19K15597, KAKENHI-PROJECT-18H02616, KAKENHI-PLANNED-17H06421, KAKENHI-PROJECT-19H05648
[Journal Article] Mutations in POMGNT1 cause non-syndromic retinitis pigmentosa.2016
- Author(s)
  Mingchu Xu, Takeyuki Yamada, Zixi Sun, Aiden Eblimit, Irma Lopez, Feng Wang, Hiroshi Manya, Shan Xu, Li Zhao, Yumei Li, Adva Kimchi, Dror Sharon, Ruifang Sui, Tamao Endo, Robert K. Koenekoop, Rui Chen
- Journal Title
  
  Hum. Mol. Genet.
  
  Volume: 25 Issue: 8 Pages: 1479-1488
- DOI
  10.1093/hmg/ddw022
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26110727, KAKENHI-PROJECT-26860682, KAKENHI-PROJECT-25293016, KAKENHI-PROJECT-16K08262
[Journal Article] Identification of a post-translational modification with ribitol-phosphate and its defect in muscular dystrophy2016
- Author(s)
  Kanagawa M, Kobayashi K, Tajiri M, Manya H, Kuga A, Yamaguchi Y, Akasaka-Manya K, Furukawa J, Mizuno M, Kawakami H, Shinohara Y, Wada Y, Endo T, Toda T.
- Journal Title
  
  Cell Reports
  
  Volume: 14 Issue: 9 Pages: 2209-2223
- DOI
  10.1016/j.celrep.2016.02.017
- NAID
  120005728438
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-26110712, KAKENHI-PUBLICLY-26110727, KAKENHI-PROJECT-15H04352, KAKENHI-PROJECT-26670499, KAKENHI-PROJECT-25293016, KAKENHI-PROJECT-26253057, KAKENHI-PROJECT-25460054, KAKENHI-PROJECT-16H05353
[Journal Article] POMGNT1 Is Glycosylated by Mucin-Type <i>O</i>-Glycans2015
- Author(s)
  Xin X, Akasaka-Manya K, Manya H, Furukawa J, Kuwahara N, Okada K, Tsumoto H, Higashi N, Kato R, Shinohara Y, Irimura T, Endo T.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 38 Issue: 9 Pages: 1389-1394
- DOI
  10.1248/bpb.b15-00415
- NAID
  130005096979
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460165, KAKENHI-PROJECT-26670023, KAKENHI-PUBLICLY-26110727, KAKENHI-PROJECT-26840029, KAKENHI-PROJECT-25293011, KAKENHI-PROJECT-25293016
[Journal Article] Major glycan structure underlying expression of the Lewis X epitope in the developing brain is O-mannose-linked glycans on phosphacan/RPTPβ2015
- Author(s)
  Shohei Yaji, Hiroshi Manya, Naoki Nakagawa, Hiromu Take matsu, Tamao Endo, Reiji Kannagi, Toru Yoshihara, Masahide Asano, Shogo Oka
- Journal Title
  
  Glycobiology
  
  Volume: 25 Issue: 4 Pages: 376-385
- DOI
  10.1093/glycob/cwu118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13J02038, KAKENHI-PLANNED-23110006, KAKENHI-PROJECT-24590078, KAKENHI-PROJECT-25293016, KAKENHI-PUBLICLY-26110727, KAKENHI-PROJECT-26291021, KAKENHI-PROJECT-26460090, KAKENHI-PROJECT-15K08288
[Journal Article] Human ISPD is a cytidyltransferase required for dystroglycan O-mannosylation.2015
- Author(s)
  Moniek Riemersma, D. Sean Froese, Walinka van Tol, Udo F. Engelke, Jolanta Kopec, Monique van Scherpenzeel, Angel Ashikov, Tobias Krojer4, Frank von Delft, Marco Tessari, Anna Buczkowska, Ewa Swiezewska, Lucas T. Jae, Thijn R. Brummelkamp, Hiroshi Manya, Tamao Endo, Hans van Bokhoven, Wyatt W. Yue, Dirk J. Lefeber
- Journal Title
  
  Chem. Biol.
  
  Volume: 22 Issue: 12 Pages: 1643-1652
- DOI
  10.1016/j.chembiol.2015.10.014
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26110727, KAKENHI-PROJECT-25293016
[Journal Article] An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer’s disease2015
- Author(s)
  Yasuhiko Kizuka, Shinobu Kitazume, Reiko Fujinawa, Takashi Saito, Nobuhisa Iwata, Takaomi C. Saido, Miyako Nakano, Yoshiki Yamaguchi, Yasuhiro Hashimoto
- Journal Title
  
  EMBO Mol. Med.
  
  Volume: 7(2) Issue: 2 Pages: 175-89
- DOI
  10.15252/emmm.201404438
- NAID
  120006799362
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-24110511, KAKENHI-PROJECT-24700371, KAKENHI-PROJECT-25293016, KAKENHI-PROJECT-25460054, KAKENHI-PUBLICLY-26110727, KAKENHI-PUBLICLY-26117522, KAKENHI-PROJECT-26460090, KAKENHI-PROJECT-26460394, KAKENHI-PROJECT-25430122
[Journal Article] α-Klotho mice demonstrate increased expression of the non-sulfated N-glycan form of the HNK-1 glyco-epitope in kidney tissue.2014
- Author(s)
  K. Akasaka-Manya, H. Manya, Y. Kizuka, S. Oka and T. Endo
- Journal Title
  
  J. Biochem.
  
  Volume: 156 Issue: 2 Pages: 107-113
- DOI
  10.1093/jb/mvu024
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23110006, KAKENHI-PROJECT-25293016, KAKENHI-PUBLICLY-26110727, KAKENHI-PROJECT-26291021
[Journal Article] Molecular characterization of protein O-linked mannose β-1,2-N-acetylglucosaminyltransferase 1 in Zebrafish2014
- Author(s)
  Yutaka Tamaru, Eriko Avşar-Ban, Hiroshi Manya, Tamao Endo, Shin’ichi Akiyama
- Journal Title
  
  J. Glycomics Lipidomics
  
  Volume: 4 Issue: 02 Pages: 111-111
- DOI
  10.4172/2153-0637.1000111
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24110523, KAKENHI-PROJECT-25293016
[Journal Article] Structural and biochemical characterization of O-mannose-linked HNK-1 glycan expressed on phosphacan in developing mouse brains.2014
- Author(s)
  Morise J, Kizuka Y, Yabuno K, Tonoyama Y, Hashii N, Kawasaki N, Manya H, Miyagoe-Suzuki Y, Takeda S, Endo T, Maeda N, Takematsu H, and Oka S.
- Journal Title
  
  Glycobiology
  
  Volume: 24 Issue: 3 Pages: 314-324
- DOI
  10.1093/glycob/cwt116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23110006, KAKENHI-PUBLICLY-24110523, KAKENHI-PROJECT-24590078, KAKENHI-PROJECT-25293016, KAKENHI-PROJECT-25430081
[Journal Article] Novel POMGnT1 mutations cause muscle-eye-brain disease in Chinese patients2013
- Author(s)
  Jiao H, Manya H, Wang S, Zhang Y, Li X, Xiao J, Yang Y, Kobayashi K, Toda T, Endo T, Wu X, Xiong H.
- Journal Title
  
  Mol Genet Genomics
  
  Volume: 288 Issue: 7-8 Pages: 297-308
- DOI
  10.1007/s00438-013-0749-5
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22129006, KAKENHI-PROJECT-23249049, KAKENHI-PUBLICLY-24110523, KAKENHI-PROJECT-25293016
[Journal Article] O-マンノース型糖鎖異常による筋ジストロフィー症糖鎖分析技術の高感度化がもたらす糖鎖研究の新たな展開2013
- Author(s)
  萬谷博、遠藤玉夫
- Journal Title
  
  化学と生物
  
  Volume: 51 Pages: 702-704
- NAID
  10031146869
- Data Source
  KAKENHI-PROJECT-25293016
[Journal Article] GTDC2 modifies O-mannosylated α-dystroglycan in the endoplasmic reticulum to generate N-acetyl-glucosamine epitopes reactive with CTD110.6 antibody.2013
- Author(s)
  Ogawa M, Nakamura N, Nakayama Y, Kurosaka A, Manya H, Kanagawa M, Endo T, Furukawa K, Okajim T
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 440 Issue: 1 Pages: 88-93
- DOI
  10.1016/j.bbrc.2013.09.022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23110008, KAKENHI-PUBLICLY-24110507, KAKENHI-PUBLICLY-24110508, KAKENHI-PUBLICLY-24110516, KAKENHI-PUBLICLY-24110523, KAKENHI-PROJECT-24687017, KAKENHI-PROJECT-25293016, KAKENHI-PROJECT-25670140
[Journal Article] Role of N-glycans in maintaining the activity of protein O-mannosyltransferases POMT1 and POMT2.2010
- Author(s)
  Hiroshi Manya, Keiko Akasaka-Manya, Ai Nakajima, Masao Kawakita, Tamao Endo
- Journal Title
  
  J. Biochem. 147(3)
  
  Pages: 337-344
- Data Source
  KAKENHI-PROJECT-19790244
[Journal Article] Role of N-glycans in maintaining the activity of protein O-mannosyltransferases POMT1 and POMT2.2010
- Author(s)
  Hiroshi Manya, Keiko Akasaka-Manya, Ai Nakajima, Masao Kawakita, Tamao Endo
- Journal Title
  
  Journal of Biochemistry 147
  
  Pages: 337-344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790244
[Journal Article] Regulation of mammalian protein O-mannosylation: Preferential amino acid sequence for O-mannose modification.2007
- Author(s)
  Hiroshi Manya, Takehiro Suzuki, Keiko Akasaka-Manya, Hide-Ki Ishida, Mamoru Mizuno, Yasushi Suzuki, Toshiyuki Inazu, Naoshi Dohmae, Tamao Endo
- Journal Title
  
  J. Biol. Chem. 282(28)
  
  Pages: 20200-20206
- Data Source
  KAKENHI-PROJECT-19790244
[Journal Article] Regulation of Malnmahan Protein O-amannosylation2007
- Author(s)
  Hiroshi Manya
- Journal Title
  
  Journal of Biological Chemistry 282
  
  Pages: 20200-20206
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790244
[Presentation] O-マンノース型糖鎖不全による筋萎縮モデルマウスの筋病理解析2023
- Author(s)
  丸山詩織、赤阪（萬谷）啓子、萬谷博、遠藤玉夫
- Organizer
  第46回日本基礎老化学会大会（第33回日本老年学会総会7学会合同会）
- Data Source
  KAKENHI-PROJECT-22K07436
[Presentation] マウスの加齢におけるN結合型糖鎖発現解析2023
- Author(s)
  赤阪-萬谷啓子、花松久寿、三浦信明、古川潤一、萬谷博、遠藤玉夫
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K07436
[Presentation] 先天性筋ジストロフィー症原因遺伝子産物ISPDの酵素学的解析2023
- Author(s)
  赤阪（萬谷）啓子、萬谷博、遠藤玉夫
- Organizer
  日本薬学会　第１４３年会
- Data Source
  KAKENHI-PROJECT-22K07436
[Presentation] O型糖鎖修飾によるAPPプロセシングの制御2023
- Author(s)
  萬谷啓子
- Organizer
  第４２回日本認知症学会
- Invited
- Data Source
  KAKENHI-PROJECT-22K07436
[Presentation] N-glycan expression in multiple organs during aging in mice2023
- Author(s)
  Keiko Akasaka-Manya, Hisatoshi Hanamatsu, Nobuaki Miura, Jun-ichi Furukawa, Hiroshi Manya, Tamao Endo
- Organizer
  第12回IAGGアジア/オセアニア国際老年学会議（IAGG-AOR2023）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07436
[Presentation] Sialic Acid Linkage-Specific Alkylamidation of O-Linked Glycoproteins and β- Elimination in the Presence of Pyrazolone2023
- Author(s)
  Ikuko Yokota, Takashi Nishikaze, Hisatoshi Hanamatsu, Hiroshi Manya, Keiko Akasaka-Manya, Jun-Ichi Furukawa
- Organizer
  Glyco26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07436
[Presentation] 加齢にともなう糖鎖変化の解析2023
- Author(s)
  赤阪-萬谷啓子、花松久寿、三浦信明、古川潤一、萬谷博、遠藤玉夫
- Organizer
  第46回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-22K07436
[Presentation] Comprehensive and comparative analysis of N-glycan expression in multiple organs during aging in mice2022
- Author(s)
  Keiko Akasaka-Manya, Hiroshi Manya, Jun-ichi Furukawa, Tamao Endo
- Organizer
  第４５回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-22K07436
[Presentation] 先天性筋ジストロフィー症原因遺伝子産物ISPDの酵素学的解析2022
- Author(s)
  赤阪（萬谷）啓子、萬谷博、遠藤玉夫
- Organizer
  日本薬学会　第１４３年会
- Data Source
  KAKENHI-PROJECT-22K07436
[Presentation] ヒトCDP-リビトール合成酵素の反応速度論的解析2022
- Author(s)
  赤阪（萬谷）啓子、萬谷博、遠藤玉夫
- Organizer
  第９５回日本日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K07436
[Presentation] Altered expression of ppGalNAc-T7 associated with decreased lung function2021
- Author(s)
  Keiko Akasaka-Manya, Pornparn Kongpracha,Hiroshi Manya, Shushi Nagamori, Tamao Endo
- Organizer
  第44回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-19K07883
[Presentation] マウス老化肺における糖転移酵素ppGalNAc-T7 の発現変化2020
- Author(s)
  赤阪（萬谷）啓子、Pornparn Kongpracha、萬谷博、永森收志、遠藤玉夫
- Organizer
  第39回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-19K07883
[Presentation] 肺の老化にともなう糖転移酵素ppGalNAc-Tの発現変化2020
- Author(s)
  赤阪（萬谷）啓子、Pornparn Kongpracha、萬谷博、永森收志、遠藤玉夫
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K07883
[Presentation] 肺の老化にともなうppGalNAc-Tの発現変化2020
- Author(s)
  赤阪（萬谷）啓子、Porparn Kongpracha、萬谷博、永森收志、遠藤玉夫
- Organizer
  第43回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-19K07883
[Presentation] Reduction of α-Klotho and pulmonary emphysema in aging2019
- Author(s)
  Keiko Akasaka-Manya, Hiroshi Manya, Satomi Nadanaka, Hiroshi Kitagawa, Yoshitaka Kondo, Akihito Ishigami, Tamao Endo
- Organizer
  Proteoglycans 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07883
[Presentation] α-Klothoの欠損による糖鎖異常2015
- Author(s)
  生形亮介、赤阪啓子、萬谷　博、遠藤玉夫
- Organizer
  首都大学東京バイオコンファレンス2015
- Place of Presentation
  首都大学東京（東京都・八王子市）
- Year and Date
  2015-11-06
- Data Source
  KAKENHI-PROJECT-25293016
[Presentation] O-Man転移酵素複合体によるドリコールリン酸マンノースの供給メカニズム2015
- Author(s)
  萬谷　博、山田健之、遠藤玉夫
- Organizer
  第1回日本筋学会学術集会
- Place of Presentation
  国立研究開発法人国立精神・神経医療研究センター（東京都・小平市）
- Year and Date
  2015-08-08
- Data Source
  KAKENHI-PROJECT-25293016
[Presentation] 糖転移酵素異常による筋疾患モデルマウスの筋病理解析2015
- Author(s)
  井上貴美子、山田健之、萬谷　博、赤阪- 萬谷啓子、櫻井洋子、遠藤玉夫
- Organizer
  日本基礎老化学会第38回大会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2015-06-12
- Data Source
  KAKENHI-PROJECT-25293016
[Presentation] ドリコールリン酸マンノースの供給におけるPOMT-DPM複合体の働き2015
- Author(s)
  山田健之、萬谷　博、遠藤玉夫
- Organizer
  第34回日本糖質学会年会
- Place of Presentation
  東京大学（東京都・文京区）
- Year and Date
  2015-07-31
- Data Source
  KAKENHI-PROJECT-25293016
[Presentation] 糖転移酵素POMGnT1の糖鎖認識機構解析2015
- Author(s)
  桑原直之、萬谷　博、山田健之、舘野浩章、平林　淳、千田俊哉、遠藤玉夫、加藤龍一
- Organizer
  BMB2015第38回日本分子生物学会年会・第88回日本生化学会大会合同会
- Place of Presentation
  神戸ポートアイランド（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25293016
[Presentation] Klotho マウス肺で見られる糖タンパク質の局在変化の解析2015
- Author(s)
  赤阪―萬谷啓子、萬谷博、遠藤玉夫
- Organizer
  日本基礎老化学会第38回大会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2015-06-12
- Data Source
  KAKENHI-PROJECT-25293016
[Presentation] 小胞体におけるドリコールリン酸マンノースの供給機構の研究2015
- Author(s)
  山田健之、萬谷　博、遠藤玉夫
- Organizer
  BMB2015第38回日本分子生物学会年会・第88回日本生化学会大会合同会
- Place of Presentation
  神戸ポートアイランド（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25293016
[Presentation] 老化に伴って増加する非硫酸化グルクロン酸によるCD13の活性変化2015
- Author(s)
  赤阪－萬谷啓子、萬谷　博、岡　昌吾、遠藤玉夫
- Organizer
  第34回日本糖質学会年会
- Place of Presentation
  東京大学（東京都・文京区）
- Year and Date
  2015-07-31
- Data Source
  KAKENHI-PROJECT-25293016
[Presentation] 組換え糖転移酵素POMGnT1のO-結合型糖鎖解析2015
- Author(s)
  津元裕樹、萬谷　博、遠藤玉夫、三浦ゆり
- Organizer
  日本質量分析学会第63回質量分析総合討論会
- Place of Presentation
  つくば国際会議場（茨城県・つくば市）
- Year and Date
  2015-06-17
- Data Source
  KAKENHI-PROJECT-25293016
[Presentation] O型糖鎖修飾によるアミロイドβ産生への影響2014
- Author(s)
  川村方希、赤阪-萬谷啓子、萬谷博、櫻井洋子、遠藤玉夫
- Organizer
  首都大学東京バイオコンファレンス2014
- Place of Presentation
  東京
- Year and Date
  2014-11-17
- Data Source
  KAKENHI-PROJECT-25293016
[Presentation] Functional interaction of POMT and DPM synthase in protein O-mannosylation2014
- Author(s)
  Hiroshi Manya, Takeyuki Yamada, Tetsuo Takahashi, Keiko Akasaka-Manya, Tamao Endo
- Organizer
  Satellite Symposia II in Joint Meeting of the Society for Glycobiology and the Japanese Society of Carbohydrate Research
- Place of Presentation
  Honolulu
- Year and Date
  2014-11-16
- Data Source
  KAKENHI-PROJECT-25293016
[Presentation] ヒトPOMGnT1のO型糖鎖修飾の解析2013
- Author(s)
  赤阪-萬谷啓子、辛欣、萬谷博、遠藤玉夫
- Organizer
  第86回生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25293016
[Presentation] Regulation of beta-amyloid production in Alzheimer's disease by N-glycan processing.2011
- Author(s)
  Endo, T., Manya, H., Akasaka-Manya, K.
- Organizer
  10th International Conference AD/PD 2011
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-22790330
[Presentation] Regulation of beta-amyloid production in Alzheimer's diseas e by N-glycan processing.2011
- Author(s)
  Endo, T., Manya, H., andAkasaka-Manya, K
- Organizer
  10th International Conference AD/PD 2011
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-22790330
[Presentation] Inhibitory effect of N-acetylglucosaminyltransferase III onβ-amyloid production in Alzheimer's disease2010
- Author(s)
  Manya, H., Akasaka-Manya, K., and Endo, T
- Organizer
  Neuros cience 2010
- Place of Presentation
  San Diego, California, USA
- Data Source
  KAKENHI-PROJECT-22790330
[Presentation] Protective effect of N-glycan bisecting GlcNAc residues onβ-amyloid produc tion in Alzheimer's disease2010
- Author(s)
  Akasaka-Manya, K., Manya, H., Sakurai, Y., Wojczyk, B. S., Kozutsumi, Y., Saito, Y., Taniguchi, N., Murayama, S., Spitalnik, S. L., and Endo, T
- Organizer
  The 28th Naito Conference Glycan Expression and Regulation[I]
- Place of Presentation
  Hayama, Japan
- Data Source
  KAKENHI-PROJECT-22790330
[Presentation] Structural alteration of N-glycan on APP and β-amyloid production. GlycoT 2010 (7th International Symposium on Glycosyltransferase)2010
- Author(s)
  Akasaka-Manya, K., Manya, H., Sakurai, Y., Saito, Y., Murayama, S., Endo, T.
- Organizer
  GlycoT 2010 (7th International Symposium on Glycosyltransferase)
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-22790330
[Presentation] Protective effect of N-glycan bisecting GlcNAc residues on β-amyloid production in Alzheimer's disease.2010
- Author(s)
  Akasaka-Manya, K., Manya, H., Sakurai, Y., Wojczyk, B.S., Kozutsumi, Y., Saito, Y., Taniguchi, N., Murayama, S., Spitalnik, S.L., Endo, T.
- Organizer
  The 28th Naito Conference Glycan Expression and Regulation [I]
- Place of Presentation
  Hayama, Japan
- Data Source
  KAKENHI-PROJECT-22790330
[Presentation] ヒトO-マンノース転移酵素におけるN型糖鎖修飾の解析2010
- Author(s)
  萬谷博、赤阪-萬谷啓子、遠藤玉夫
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-19790244
[Presentation] Structural alteration of N-glycan on APP andβ-amyloid production2010
- Author(s)
  Akasaka-Manya, K., Manya, H., Sakurai, Y., Saito, Y., Murayama, S., Endo, T
- Organizer
  7th International Symposium on Glycosyltransferase
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-22790330
[Presentation] Inhibitory effect of N-acetylglucosaminyltransferase III on β-amyloid production in Alzheimer's disease.2010
- Author(s)
  Manya, H., Akasaka-Manya, K., Endo, T.
- Organizer
  Neuroscience 2010
- Place of Presentation
  San Diego, California, USA
- Data Source
  KAKENHI-PROJECT-22790330
[Presentation] 先天性筋ジストロフィーにおける糖鎖異常2009
- Author(s)
  遠藤玉夫、赤阪-萬谷啓子、萬谷博
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19790244
[Presentation] Role on N-glycans on protein O-mannosyltransferases POMT1 and POMT2.2009
- Author(s)
  Hiroshi Manya, Keiko Akasaka-Manya, Tamao Endo
- Organizer
  Austria/Japan Seminar on Comparative Glycobiology and Developmental Biology
- Place of Presentation
  Hayama, Japan
- Data Source
  KAKENHI-PROJECT-19790244
[Presentation] Role on N-glycans on protein O-mannosyltransferases POMT1 and POMT22009
- Author(s)
  Hiroshi Manya
- Organizer
  Austria/Japan Seminar on Comparative Glycobiology and Developmental Biology
- Place of Presentation
  Hayama
- Data Source
  KAKENHI-PROJECT-19790244
[Presentation] O-マンノース転移酵素におけるN型糖鎖の役割2008
- Author(s)
  萬谷博、赤阪-萬谷啓子、遠藤玉夫
- Organizer
  第28回日本糖質学会年会
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PROJECT-19790244
[Presentation] O-マンノース転移酵素におけるN型糖鎖の役割2008
- Author(s)
  萬谷博、赤阪-萬谷啓子、遠藤玉夫
- Organizer
  第81回日本生化学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19790244
[Presentation] O-マンノース転移酵素におけるN型糖鎖の役割2008
- Author(s)
  萬谷博
- Organizer
  第81回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-19790244
[Presentation] 神経移動障害を伴う先天性筋ジストロフィー2008
- Author(s)
  遠藤玉夫、萬谷博、赤阪-萬谷啓子
- Organizer
  第31回日本神経科学大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19790244
[Presentation] O-マンノース転移酵素におけるN型糖鎖の役割2008
- Author(s)
  萬谷博
- Organizer
  第28回日本糖質学会年会
- Place of Presentation
  つくば国際会議場
- Data Source
  KAKENHI-PROJECT-19790244
[Presentation] Biochemical approach forα-dystroglycanopathies: Identification of consensus sequence for protein O-mannosylation.2007
- Author(s)
  Hiroshi Manya, Takehiro Suzuki, Keiko Akasaka-Manya, Naoshi Dohmae, Tamao Endo
- Organizer
  12th International Congress of the World Muscle Society
- Place of Presentation
  Taormina, Italy
- Data Source
  KAKENHI-PROJECT-19790244
[Presentation] Preferential amino acid sequence for protein O-mannosylation.2007
- Author(s)
  Hiroshi Manya, Takehiro Suzuki, Keiko Akasaka-Manya, Naoshi Dohmae, Tamao Endo
- Organizer
  XIX International Symposium on Glycoconjugates (GLYCO-19)
- Place of Presentation
  Cairns, Australia
- Data Source
  KAKENHI-PROJECT-19790244
[Presentation] 哺乳類0・マンノース転移酵素の基質特異性の解析2007
- Author(s)
  赤阪(萬谷) 啓子
- Organizer
  BMB2007
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19790244
[Presentation] 先天性筋ジストロフィーと糖鎖異常2007
- Author(s)
  遠藤玉夫、萬谷博、赤阪啓子
- Organizer
  Biochemistry and Molecular biology 2007 (BMB2007)
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-19790244
[Presentation] Identification of preferential sequence for protein O-mannosylation.2007
- Author(s)
  Hiroshi Manya, Naoshi Dohmae, Keiko Akasaka, Toshiyuki Inazu, Tamao Endo
- Organizer
  Biochemistry and Molecular biology 2007 (BMB2007)
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-19790244
[Presentation] Increased expression of the non-sulfated HNK-1 in α-Klotho mouse kidney.
- Author(s)
  赤阪-萬谷啓子、萬谷博、木塚康彦、岡昌吾、遠藤玉夫
- Organizer
  第37回日本基礎老化学会大会
- Place of Presentation
  愛知
- Year and Date
  2014-06-26 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-25293016
[Presentation] 神経系に発現するLewis X抗原のキャリアタンパク質および生合成酵素の解析
- Author(s)
  中川直樹、萬谷博、家治翔平、竹松弘、遠藤玉夫、神奈木玲児、吉原亨、浅野雅秀、岡昌吾
- Organizer
  第33回日本糖質学会年会
- Place of Presentation
  名古屋
- Year and Date
  2014-08-10 – 2014-08-12
- Data Source
  KAKENHI-PROJECT-25293016
[Presentation] 糖鎖修飾酵素POMGnT1ステムドメインの機能同定と糖鎖認識機構解析
- Author(s)
  桑原直之、萬谷博、舘野浩章、平林淳、遠藤玉夫、千田俊哉、加藤龍一
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25293016
[Presentation] Functional interaction of POMT and DPM synthase in protein O-mannosylation
- Author(s)
  Hiroshi Manya, Takeyuki Yamada, Tetsuo Takahashi, Keiko Akasaka-Manya, Tamao Endo
- Organizer
  Joint Meeting of the Society for Glycobiology and the Japanese Society of Carbohydrate Research
- Place of Presentation
  Honolulu
- Year and Date
  2014-11-16 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-25293016
[Presentation] 小胞体におけるマンノース付加の制御機構
- Author(s)
  山田健之、萬谷博、遠藤玉夫
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25293016
[Presentation] α-Klothoの欠損によって生じる非硫酸化HNK-1糖鎖の蓄積
- Author(s)
  赤阪－萬谷啓子、萬谷博、木塚康彦、岡昌吾、遠藤玉夫
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25293016
[Presentation] Bisecting GlcNAc欠損によるアルツハイマー病抑制に関する研究
- Author(s)
  木塚康彦、北爪しのぶ、藤縄玲子、斉藤貴志、岩田修永、西道隆臣、中の三弥子、山口芳樹、橋本康弘、Matthias Staufenbiel、初田裕幸、村山繁雄、萬谷博、遠藤玉夫、谷口直之
- Organizer
  第33回日本糖質学会年会
- Place of Presentation
  名古屋
- Year and Date
  2014-08-10 – 2014-08-12
- Data Source
  KAKENHI-PROJECT-25293016
[Presentation] GTDC2はαジストログリカンのO-ManにCTD110.6抗体が認識するGlcNAcを修飾する
- Author(s)
  小川光貴、澤口翔伍、中村直介、中山喜明、黒坂光、萬谷博、金川基、遠藤玉夫、古川鋼一、岡島徹也
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25293016
[Presentation] Analysis of protein O-mannosyltransferase complex formation in the endoplasmic reticulum.
- Author(s)
  Endo, T., Yamada, T., Takahashi, T., Akasaka-Manya, K., Manya, H.
- Organizer
  9th International Symposium on Glycosyltransferases (Glyco-T 2014)
- Place of Presentation
  Porto, Portugal
- Year and Date
  2014-06-18 – 2014-06-21
- Data Source
  KAKENHI-PROJECT-25293016
[Presentation] 先天性筋ジストロフィー症の原因遺伝子産物POMGnT1の糖鎖修飾
- Author(s)
  辛欣、川村方希、赤阪-萬谷啓子、萬谷博、遠藤玉夫
- Organizer
  首都大学東京バイオコンファレンス2013
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25293016
[Presentation] 神経回路形成期におけるホスファカン上の特徴的なO-マンノース型HNK-1糖鎖構造の解析
- Author(s)
  森瀬譲二、木塚康彦、藪野景子、殿山泰弘、橋井則貴、川崎ナナ、萬谷博、鈴木友子、武田伸一、遠藤玉夫、前田信明、竹松弘、岡昌吾
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25293016
[Presentation] 糖鎖修飾におけるドリコールリン酸マンノース供給の制御機構
- Author(s)
  山田健之、萬谷博、遠藤玉夫
- Organizer
  第33回日本糖質学会年会
- Place of Presentation
  名古屋
- Year and Date
  2014-08-10 – 2014-08-12
- Data Source
  KAKENHI-PROJECT-25293016
[Presentation] アルツハイマー病患者の脳における糖転移酵素の発現解析
- Author(s)
  萬谷博、赤阪-萬谷啓子、遠藤玉夫
- Organizer
  第33回日本糖質学会年会
- Place of Presentation
  名古屋
- Year and Date
  2014-08-10 – 2014-08-12
- Data Source
  KAKENHI-PROJECT-25293016
[Presentation] Klothoマウス腎臓における非硫酸化HNK-1糖鎖の増加
- Author(s)
  赤阪-萬谷啓子、萬谷博、木塚康彦、岡昌吾、遠藤玉夫
- Organizer
  第33回日本糖質学会年会
- Place of Presentation
  名古屋
- Year and Date
  2014-08-10 – 2014-08-12
- Data Source
  KAKENHI-PROJECT-25293016

1. Endo Tamao (30168827)

# of Collaborated Projects: 1 results

# of Collaborated Products: 32 results
2. Masami Miura (40291091)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. Miura Yuri (00216574)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. NADANAKA Satomi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. KAWASAKI Nana

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. MORISE Jyoji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. YAGI Hirokazu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. KANAGAWA Motoi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 岡昌吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 萬谷博

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
11. 小林千浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 戸田達史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 竹松弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 橋本康弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 古川鋼一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Manya Keiko 萬谷 啓子

MANYA KEIKO 萬谷 啓子

Keiko Manya 萬谷 啓子

MANYA Keiko 萬谷 啓子

Research Projects

Research Products

Co-Researchers

老化組織で増加するパウチマンノース型糖鎖の生理機能と発現機構の解明Principal Investigator

Principal Investigator

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Review Section

Research Institution

オミクス解析による肺の老化メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Regulatory Mechanism of APP Metabolism by O-GlycosylationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

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Molecular basis of regulation of nerve function by glycosylation

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Regulation of APP metabolism by glycosyltransferasePrincipal Investigator

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Glycosyltransferases on muscular dystrophy and their breakdown.Principal Investigator

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[Book] 腎臓内科第18巻第1号2023

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[Book] 食品免疫学事典2021

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[Book] Vitamins and Hormones.2016

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[Book] Sugar chains2015

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[Book] Handbook of Glycosyl transferases and related genes. (Part3-16 : POMT1,2)2014

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[Book] Handbook of Glycosyltransferases and related genes2014

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[Book] Handbook of Glycosyltransferases and related genes. (Part4-30 : POMGnT1)2014

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[Journal Article] Enzyme assay of protein O-mannosyltransferase (POMT1/2)2023

Manya Keiko 萬谷啓子

MANYA KEIKO 萬谷啓子

Keiko Manya 萬谷啓子

MANYA Keiko 萬谷啓子