Yamauchi Kazuyoshi 山内一由

Researcher Number	70419414
Other IDs	https://orcid.org/0000-0003-3666-2455
Affiliation (Current)	2025: 信州大学, 学術研究院保健学系, 教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 信州大学, 学術研究院保健学系, 教授 2018 – 2020: 筑波大学, 医学医療系, 准教授
Review Section/Research Field	Principal Investigator Basic Section 52010:General internal medicine-related
Keywords	Principal Investigator apolipoprotein E / LRP1 / レドックス変化 / リポ蛋白代謝 / 動脈硬化症 / レドックス状態 / 脂質代謝 / 敗血症 / syndecan-1 / LDL受容体関連蛋白 … More / ヘパラン硫酸プロテオグリカン / リポ蛋白リパーゼ / 動脈硬化 / LRP-1 / LPL / レムナントリポ蛋白 / Syndecan-1 / 蛍光標識エマルジョン / ヒト繊維芽細胞 / Cys-thiol 基 / apo E / apoE / Cys基 / システイン残基 / システイン / DMPCクリアランス / ジスフフィド結合 / apolipoprotein AII / レドックスindex / Cysteine-thiol 基 / 血清apoE / アルツハイマー病 / 酸化ストレス / Cystein-thiol / アポリポ蛋白 E Less

apoE-SDC1-LRP1を介した脂質代謝と炎症反応との連関機構と敗血症による破綻機序の解明Principal Investigator
- Principal Investigator
  
  山内一由
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Shinshu University
Impact of cysteine modifications of apolipoprotein E on the remnant lipoprotein metabolismPrincipal Investigator
- Principal Investigator
  
  Yamauchi Kazuyoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Shinshu University
Redox status of apolipoprotein E and its pathophysiological significancePrincipal Investigator
- Principal Investigator
  
  Yamauchi Kazuyoshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  University of Tsukuba

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation Book

[Book] 最新臨床検査学講座　臨床化学検査学第３版2024
- Author(s)
  戸塚実、奥村伸生、浦山修、松下誠、山内一由、大川龍之介
- Total Pages
  452
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-21K07310
[Book] 最新臨床検査学講座臨床化学検査学第2版2022
- Author(s)
  戸塚実、奥村伸生、浦山修、松下誠、山内一由、大川龍之介
- Total Pages
  472
- Publisher
  医歯薬出版
- ISBN
  9784263223864
- Data Source
  KAKENHI-PROJECT-21K07310
[Book] 染色法のすべて2021
- Author(s)
  水口　國雄、山内　一由他
- Total Pages
  446
- Publisher
  医歯薬出版
- ISBN
  9784263226902
- Data Source
  KAKENHI-PROJECT-18K07461
[Book] 臨床検査法提要改訂第35版2020
- Author(s)
  金井正光、奥村伸夫、戸塚実、本田孝行、矢冨裕　山内　一由他
- Total Pages
  2016
- Publisher
  金原出版
- ISBN
  9784307050531
- Data Source
  KAKENHI-PROJECT-18K07461
[Journal Article] Apolipoprotein E isoforms and their Cys‐thiol modifications impact <scp>LRP1</scp>‐mediated metabolism of triglyceride‐rich lipoproteins2024
- Author(s)
  Matsuura Hiroto、Akahane Shogo、Kaido Takahiro、Kamijo Tomu、Sakamoto Kenta、Yamauchi Kazuyoshi
- Journal Title
  
  FEBS Letters
  
  Volume: 598 Issue: 3 Pages: 347-362
- DOI
  10.1002/1873-3468.14803
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07310
[Journal Article] Apolipoprotein E-containing lipoproteins and their extracellular interactions with LRP1 affect LPS-induced inflammation2024
- Author(s)
  Akahane Shogo、Matsuura Hiroto、Kaido Takahiro、Usami Yoko、Ishimine Nau、Uehara Takeshi、Yamauchi Kazuyoshi
- Journal Title
  
  Biological Chemistry
  
  Volume: － Issue: 6 Pages: 383-393
- DOI
  10.1515/hsz-2024-0018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07310
[Journal Article] Redox index of Cys-thiol residues of serum apolipoprotein E and its diagnostic potential2021
- Author(s)
  Kazuyoshi Yamauchi, Chiaki Taira, Yasushi Kawakami
- Journal Title
  
  Bioscience Reports
  
  Volume: 41 Issue: 8 Pages: 1-11
- DOI
  10.1042/bsr20211060
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07461, KAKENHI-PROJECT-21K07310
[Journal Article] A novel variant fibrinogen, AαE11del, demonstrating the important of AαE11 residue in thrombin binding2021
- Author(s)
  Kaido T, Yoda M, Kamijo T, Arai S, Yamauchi K, Okumura N
- Journal Title
  
  Int J Hematology
  
  Volume: 114 Issue: 5 Pages: 591-598
- DOI
  10.1007/s12185-021-03200-z
- NAID
  120007180889
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07799, KAKENHI-PROJECT-21K07310, KAKENHI-PROJECT-21K15945
[Journal Article] Relationships between Cognitive Function and Odor Identification, Balance Capability, and Muscle Strength in Middle-Aged Persons with and without Type 2 Diabetes2021
- Author(s)
  Midorikawa Manabu、Suzuki Hiroaki、Suzuki Yasuhiro、Yamauchi Kazuyoshi、Sato Hiroyuki、Nemoto Kiyotaka、Sugano Yoko、Iwasaki Hitoshi、Sekiya Motohiro、Yatoh Shigeru、Yahagi Naoya、Hada Yasushi、Arai Tetsuaki、Shimano Hitoshi
- Journal Title
  
  Journal of Diabetes Research
  
  Volume: 2021 Pages: 1-14
- DOI
  10.1155/2021/9961612
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K18164, KAKENHI-PROJECT-21K07310
[Journal Article] Recombinant γY278H fibrinogen shows normal secretion from CHO cells, but a corresponding heterozygous patient showed hypofibrinogenemia2021
- Author(s)
  KamijoT, Kaido T, Yoda M, Arai S, Yamauchi K, Okumura N.
- Journal Title
  
  Int J Mol Sci
  
  Volume: 22 Issue: 10 Pages: 5218-5218
- DOI
  10.3390/ijms22105218
- NAID
  120007180886
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07799, KAKENHI-PROJECT-21K07310, KAKENHI-PROJECT-21K15945
[Journal Article] Cut-off values of serum IgG4 among three reagents, including a novel IgG4 reagent: a multicenter study2021
- Author(s)
  Usami Yoko、Sugano Mitsutoshi、Uehara Takeshi、Koinuma Masayoshi、Ishimine Nau、Kawasaki Kenji、Yamauchi Kazuyoshi、Hamano Hideaki、Honda Takayuki
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 1-7
- DOI
  10.1038/s41598-021-86024-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07461, KAKENHI-PROJECT-20K07405, KAKENHI-PROJECT-21K07310
[Journal Article] The redox status of cysteine thiol residues of apolipoprotein E impacts on its lipid interactions.2020
- Author(s)
  Yamauchi Kazuyoshi, Kawakami Yasushi.
- Journal Title
  
  Biological Chemistry
  
  Volume: 401 Issue: 5 Pages: 617-627
- DOI
  10.1515/hsz-2019-0414
- NAID
  120007127616
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07461
[Journal Article] Evaluation of a novel serum IgG4 assay and determination of reference interval for the Japanese population.2020
- Author(s)
  Usami Yoko, Ichihara Kiyoshi, Uehara Takashi, Sugano Mitsutoshi, Ishimine Nau, Kawasaki Kenji, Yamauchi Kazuyoshi, Hamano Hideaki, Honda Takayuki
- Journal Title
  
  Clinica Chimica Acta
  
  Volume: 501 Pages: 136-141
- DOI
  10.1016/j.cca.2019.10.032
- NAID
  120007127695
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07461, KAKENHI-PROJECT-16H02771, KAKENHI-PROJECT-17K08738
[Journal Article] Redox equilibrium of serum apolipoprotein E3: A buffering effect of disulfide-linked complexes against oxidative stress on apolipoprotein E3-containing lipoproteins2019
- Author(s)
  Yamauchi Kazuyoshi、Iwasaki Shio、Kawakami Yasushi
- Journal Title
  
  Bioscience Reports
  
  Volume: - Issue: 4 Pages: 1-10
- DOI
  10.1042/bsr20190184
- NAID
  120007127951
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07461
[Journal Article] 臨床検査学教育における客観的臨床能力試験の有用性2019
- Author(s)
  服部圭一朗; 會田雄一; 山内一由; 二宮治彦
- Journal Title
  
  臨床検査学教育
  
  Volume: 11 Pages: 188-194
- NAID
  40022025415
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07461
[Presentation] LPS誘発性炎症反応におけるLRP1の病態生理学的意義2023
- Author(s)
  赤羽匠吾、松浦弘人、坂本健太、山内一由
- Organizer
  第63回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K07310
[Presentation] LRP1を介したapoE含有リポ蛋白代謝におけるapoE-Cys基のレドックス修飾の影響2023
- Author(s)
  松浦弘人、赤羽匠吾、石嶺南生、山内一由
- Organizer
  第63回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K07310
[Presentation] LPS誘発性炎症反応に及ぼすapoE含有リポ蛋白の影響2023
- Author(s)
  赤羽匠吾、松浦弘人、山内一由
- Organizer
  日本医療検査科学会第５５回大会
- Data Source
  KAKENHI-PROJECT-21K07310
[Presentation] LRP1を介したapoE含有リポ蛋白代謝におけるapoEアイソフォームの影響2023
- Author(s)
  松浦弘人、赤羽匠吾、石嶺南生、山内一由
- Organizer
  日本医療検査科学会第５５回大会
- Data Source
  KAKENHI-PROJECT-21K07310
[Presentation] 筑波大学における臨地実習前OSCEの実践と課題2019
- Author(s)
  會田雄一; 山内一由; 二宮治彦
- Organizer
  2019年度日臨技首都圏支部・関甲信支部医学検査学会（第56回）
- Data Source
  KAKENHI-PROJECT-18K07461
[Presentation] 履修証明プログラム「多職種連携メディカルスタッフ教育プログラム」の普及とコンテンツ更新に関する課題2018
- Author(s)
  會田雄一、服部圭一朗、真家紘一郎、関本道治、山内一由、二宮治彦
- Organizer
  第11回日本保健医療福祉連携教育学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07461
[Presentation] 臨地実習後の項目別自己評価：OSLE客観評価との関連性の検討2018
- Author(s)
  服部圭一朗、會田雄一、真家紘一郎、山内一由、森川一也、中川嘉、吉田文代、小池朗、二宮治彦
- Organizer
  第13回日本臨床検査学教育学会学術大会
- Data Source
  KAKENHI-PROJECT-18K07461
[Presentation] 大学と病院をつなぐ多職種連携医療専門職養成プログラムの成果2018
- Author(s)
  會田雄一、山内一由、関本道治、真家紘一郎、二宮治彦
- Organizer
  第67回日本医学検査学会
- Data Source
  KAKENHI-PROJECT-18K07461

1. OKUMURA Nobuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 新井慎平

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 根本清貴

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamauchi Kazuyoshi 山内 一由

Research Projects

Research Products

Co-Researchers

apoE-SDC1-LRP1を介した脂質代謝と炎症反応との連関機構と敗血症による破綻機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Impact of cysteine modifications of apolipoprotein E on the remnant lipoprotein metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Redox status of apolipoprotein E and its pathophysiological significancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 最新臨床検査学講座 臨床化学検査学第３版2024

Author(s)

Total Pages

Publisher

Data Source

[Book] 最新臨床検査学講座 臨床化学検査学 第2版2022

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 染色法のすべて2021

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 臨床検査法提要 改訂第35版2020

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Apolipoprotein E isoforms and their Cys‐thiol modifications impact <scp>LRP1</scp>‐mediated metabolism of triglyceride‐rich lipoproteins2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Apolipoprotein E-containing lipoproteins and their extracellular interactions with LRP1 affect LPS-induced inflammation2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Redox index of Cys-thiol residues of serum apolipoprotein E and its diagnostic potential2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel variant fibrinogen, AαE11del, demonstrating the important of AαE11 residue in thrombin binding2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Relationships between Cognitive Function and Odor Identification, Balance Capability, and Muscle Strength in Middle-Aged Persons with and without Type 2 Diabetes2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Recombinant γY278H fibrinogen shows normal secretion from CHO cells, but a corresponding heterozygous patient showed hypofibrinogenemia2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Cut-off values of serum IgG4 among three reagents, including a novel IgG4 reagent: a multicenter study2021

Author(s)

Journal Title

Yamauchi Kazuyoshi 山内一由

[Book] 最新臨床検査学講座　臨床化学検査学第３版2024

[Book] 最新臨床検査学講座臨床化学検査学第2版2022

[Book] 臨床検査法提要改訂第35版2020