Kuroda Junya 黒田純也

… Alternative Names

JUNYA KURODA 黒田純也

KURODA Junya 黒田純也

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Researcher Number	70433258
Other IDs	https://orcid.org/0000-0001-6130-1550
Affiliation (Current)	2024: 京都府立医科大学, 医学(系)研究科(研究院), 教授
Affiliation (based on the past Project Information) *help	2019 – 2022: 京都府立医科大学, 医学(系)研究科(研究院), 教授 2016: 京都府立医科大学, 医学(系)研究科(研究院), 教授 2011 – 2015: 京都府立医科大学, 医学(系)研究科(研究院), 講師 2014: 京都府立医科大学, 医学部附属病院, 講師 2008: Kyoto Prefectural University of Medicine, 医学研究科, 助教 2008: Kyoto Prefectural University of Medicine, 医学部, 助教 2007: Kyoto Prefectural University of Medicine, 医学部附属病院, 専攻医
Review Section/Research Field	Principal Investigator Hematology / Basic Section 54010:Hematology and medical oncology-related Except Principal Investigator Hematology
Keywords	Principal Investigator RSK2 / 多発性骨髄腫 / 分子標的 / 創薬 / AKT / PDPK1 / 慢性骨髄性白血病 / 悪性リンパ腫 / S6K / 創薬研究 … More / Bid / BH3-only protein / 小分子化合物 / 造血器腫瘍 / エピジェネティック / 造血器悪性腫瘍 / エピジェネティックス / miR-375 / 治療抵抗性 / 腫瘍環境 / ガレクチンー3 / MCL-1 / BID / BIM / アポトーシス / FTY720 / 骨髄腫瘍環境 / ガレクチン-3 / Bcr-Ab1 / 分子標的治療 / チロシンキナーゼ阻害剤 / Glyoxalase-I / 解糖系 / Bcr-Abl / 骨髄ニッチ / 低酸素 … More Except Principal Investigator 幹細胞能 / オートクライン・パラクライン / 骨髄腫瘍環境由来治療抵抗性 / Galectin-3 / 慢性骨髄性白血病 Less

Generation of RSK2/AKT/S6K tripple inhibitor for mature lymphoid malignanciesPrincipal Investigator
- Principal Investigator
  
  黒田純也
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kyoto Prefectural University of Medicine
Drug discovery targeted against RSK2 in multiple myelomaPrincipal Investigator
- Principal Investigator
  
  JUNYA KURODA
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kyoto Prefectural University of Medicine
The functional involvement of PDPK1 in the pathophysiology of multiple myelomaPrincipal Investigator
- Principal Investigator
  
  KURODA JUNYA
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kyoto Prefectural University of Medicine
The mechanism of autocrine and paracrine growth promotion of CML cells
- Principal Investigator
  
  SUGITANI Mio
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Kyoto Prefectural University of Medicine
Molecular and cellular effects of tumor microenvironment-specific Galectin-3 in leukemiaPrincipal Investigator
- Principal Investigator
  
  KURODA Junya
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kyoto Prefectural University of Medicine
Drug resistance mediated by hypoxic bone marrow leukemia environment in chronic myelogenous leukemiaPrincipal Investigator
- Principal Investigator
  
  KURODA Junya
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Kyoto Prefectural University of Medicine

All 2023 2022 2021 2020 2017 2016 2015 2014 2013 2012 2011 2008 2007 Other

All Journal Article Presentation Book

[Book] 造血器腫瘍アトラス改訂第５版2016
- Author(s)
  谷脇雅史、横田昇平、黒田純也
- Total Pages
  862
- Publisher
  日本医事新報社
- Data Source
  KAKENHI-PROJECT-26461429
[Book] 慢性骨髄性白血病の薬剤耐性機構. Annual Review血液20132013
- Author(s)
  黒田純也
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-23591403
[Book] 慢性骨髄性白血病に対するチロシンキナーゼ阻害剤治療-知っておきたい基礎知識- BLOOD MASTER Vol.8「慢性骨髄性白血病」2011
- Author(s)
  黒田純也, (前川平編)
- Publisher
  大日本住友製薬
- Data Source
  KAKENHI-PROJECT-23591403
[Journal Article] The Rationale for the Dual-Targeting Therapy for RSK2 and AKT in Multiple Myeloma.2022
- Author(s)
  Isa R, Horinaka M, Tsukamoto T, Mizuhara K, Fujibayashi Y, Taminishi-Katsuragawa Y, Okamoto H, Yasuda S, Kawaji-Kanayama Y, Matsumura-Kimoto Y, Mizutani S, Shimura Y, Taniwaki M, Sakai T, Kuroda J.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 23 Issue: 6 Pages: 2919-2936
- DOI
  10.3390/ijms23062919
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08872, KAKENHI-PLANNED-17H06398, KAKENHI-PROJECT-19H01079, KAKENHI-PROJECT-19H03889, KAKENHI-PROJECT-21K16246, KAKENHI-PROJECT-21K16274
[Journal Article] Expression of activated B cell gene signature is predictive of the outcome of follicular lymphoma.2022
- Author(s)
  Tsukamoto T, Tokuda Y, Nakano M, Tashiro K, Kuroda J.
- Journal Title
  
  Blood Adv
  
  Volume: 6 Issue: 6 Pages: 1932-1936
- DOI
  10.1182/bloodadvances.2021005876
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08872, KAKENHI-PROJECT-21H02687, KAKENHI-PROJECT-20K07343, KAKENHI-PROJECT-21K06840, KAKENHI-PROJECT-21K16246
[Journal Article] Detection of novel and recurrent conjoined genes in non-Hodgkin B-cell lymphoma2021
- Author(s)
  Matsumoto Y, Tsukamoto T, Chinen Y, Shimura Y, Sasaki N, Nagoshi H, Sato R, Adachi H, Nakano M, Horiike S, Kuroda J, Taki T, Tashiro K, Taniwaki M.
- Journal Title
  
  Journal of Clinical and Experimental Hematopathology
  
  Volume: 61 Issue: 2 Pages: 71-77
- DOI
  10.3960/jslrt.20033
- NAID
  130008049325
- ISSN
  1346-4280, 1880-9952
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08872, KAKENHI-PROJECT-21H02687, KAKENHI-PROJECT-20K07343
[Journal Article] EWSR1 overexpression is a pro-oncogenic event in multiple myeloma2021
- Author(s)
  Nishiyama D, Chinen Y, Isa R, Fujibayashi Y, Kuwahara-Ota S, Yamaguchi J, Takimoto-Shimomura T, Matsumura-Kimoto Y, Tsukamoto T, Shimura Y, Kobayashi T, Horiike S, Taniwaki M, Handa H, Kuroda J.
- Journal Title
  
  Int J Hematol
  
  Volume: 113 Issue: 3 Pages: 381-394
- DOI
  10.1007/s12185-020-03027-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08872, KAKENHI-PROJECT-19K17867
[Journal Article] Serine-227 in the N-terminal kinase domain of RSK2 is a potential therapeutic target for mantle cell lymphoma2020
- Author(s)
  Matsumura-Kimoto Y, Tsukamoto T, Shimura Y, Chinen Y, Tanba K, Kuwahara-Ota S, Fujibayashi Y, Nishiyama D, Isa R, Yamaguchi J, Kawaji-Kanayama Y, Kobayashi T, Horiike S, Taniwaki M, Kuroda J
- Journal Title
  
  Cancer Med
  
  Volume: 9 Issue: 14 Pages: 5185-5199
- DOI
  10.1002/cam4.3136
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08872, KAKENHI-PROJECT-19K17867
[Journal Article] Toward further simplification of elotuzumab therapy by subcutaneous administration2020
- Author(s)
  Shimura Y, Tsukamoto T, Yamaguchi J, Kuwahara-Ota S, Isa R, Nishiyama D, Kobayashi T, Horiike S, Suzuki A, Kuroda J
- Journal Title
  
  Int J Hematol
  
  Volume: 112 Issue: 3 Pages: 427-428
- DOI
  10.1007/s12185-020-02942-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08872
[Journal Article] Aberrant BUB1 Overexpression Promotes Mitotic Segregation Errors and Chromosomal Instability in Multiple Myeloma2020
- Author(s)
  Fujibayashi Y, Isa R, Nishiyama D, Sakamoto-Inada N, Kawasumi N, Yamaguchi J, Kuwahara-Ota S, Matsumura-Kimoto Y, Tsukamoto T, Chinen Y, Shimura Y, Kobayashi T, Horiike S, Taniwaki M, Handa H, Kuroda J
- Journal Title
  
  Cancers
  
  Volume: 12 Issue: 8 Pages: 2206-2206
- DOI
  10.3390/cancers12082206
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08872, KAKENHI-PROJECT-18K08367, KAKENHI-PROJECT-19K17867
[Journal Article] Tumor-specific transcript variants of cyclin D1 in mantle cell lymphoma and multiple myeloma with chromosome 11q13 abnormalities2020
- Author(s)
  Chinen Yoshiaki、Tsukamoto Taku、Maegawa-Matsui Saori、Matsumura-Kimoto Yayoi、Takimoto-Shimomura Tomoko、Tanba Kazuna、Mizuno Yoshimi、Fujibayashi Yuto、Kuwahara-Ota Saeko、Shimura Yuji、Kobayashi Tsutomu、Horiike Shigeo、Taniwaki Masafumi、Kuroda Junya
- Journal Title
  
  Experimental Hematology
  
  Volume: - Pages: 45-53.e1
- DOI
  10.1016/j.exphem.2020.02.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08872, KAKENHI-PROJECT-19K17867
[Journal Article] Lenalidomide and pomalidomide potently interfere with induction of myeloid-derived suppressor cells in multiple myeloma2020
- Author(s)
  Kuwahara-Ota S, Shimura Y, Steinebach C, Isa R, Yamaguchi J, Nishiyama D, Fujibayashi Y, Takimoto-Shimomura T, Mizuno Y, Matsumura-Kimoto Y, Tsukamoto T, Chinen Y, Kobayashi T, Horiike S, Taniwaki M, Gutschow M, Kuroda J
- Journal Title
  
  Br J Haematol
  
  Volume: 191 Issue: 5 Pages: 784-795
- DOI
  10.1111/bjh.16881
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08872, KAKENHI-PROJECT-18K16125, KAKENHI-PROJECT-19K17867
[Journal Article] Epigenetic repression of miR-375 is the dominant mechanism for constitutive activation of the PDPK1/RPS6KA3 signalling axis in multiple myeloma.2017
- Author(s)
  Tatekawa S, Chinen Y, Ri M, Narita T, Shimura Y, Matsumura-Kimoto Y, Tsukamoto T, Kobayashi T, Kawata E, Uoshima N, Taki T, Taniwaki M, Handa H, Iida S, Kuroda J.
- Journal Title
  
  British Journal of Haematology
  
  Volume: 印刷中 Issue: 4 Pages: 534-546
- DOI
  10.1111/bjh.14707
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461429, KAKENHI-PROJECT-16K21284
[Journal Article] Transcriptional dysregulation of the deleted in colorectal carcinoma gene in multiple myeloma and monoclonal gammopathy of undetermined significance.2015
- Author(s)
  Nagoshi H, Taki T, Chinen Y, Tatekawa S, Tsukamoto T, Maegawa S, Yamamoto-Sugitani M, Tsutsumi Y, Kobayashi T, Matsumoto Y, Horiike S, Okuno Y, Fujiwara S, Hata H, Kuroda J, Taniwaki M.
- Journal Title
  
  Genes Chromosomes Cancer
  
  Volume: 54 Issue: 12 Pages: 788-795
- DOI
  10.1002/gcc.22290
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09486, KAKENHI-PROJECT-26461427, KAKENHI-PROJECT-26461429
[Journal Article] Phosphoinositide protein kinase PDPK1 is a crucial cell signaling mediator in multiple myeloma.2014
- Author(s)
  Chinen Y, Kuroda J, Shimura Y, Nagoshi H, Kiyota M, Yamamoto-Sugitani M, Mizutani S, Sakamoto N, Ri M, Kawata E, Kobayashi T, Matsumoto Y, Horiike S, Iida S, Taniwaki M.
- Journal Title
  
  Cancer Res
  
  Volume: 74 Issue: 24 Pages: 7418-7429
- DOI
  10.1158/0008-5472.can-14-1420
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25860792, KAKENHI-PROJECT-26461429
[Journal Article] Suppression of SERPINA1-albumin complex formation by galectin-3 overexpression leads to paracrine growth promotion of chronic myelogenous leukemia cells.2014
- Author(s)
  Nakayama R, Kuroda J, Taniyama N, Yamamoto-Sugitani M, Wada S, Kiyota M, Mizutani S, Chinen Y, Matsumoto Y, Nagoshi H, Shimura Y, Kobayashi T, Horiike S, Sato K, Taniwaki M.
- Journal Title
  
  Leukemia Research
  
  Volume: 38 Issue: 1 Pages: 103-108
- DOI
  10.1016/j.leukres.2013.07.026
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591403, KAKENHI-PROJECT-25860792
[Journal Article] Suppression of SERPINA1-albumin complex formation by galectin-3 overexpression leads to paracrine growth promotion of chronic myelogenous leukemic cells2014
- Author(s)
  Nakayama R, Kuroda J, Taniyama N, Yamamoto-Sugitani M, Wada S, Kiyota M, Mizutani S, Chinen Y, Matsumoto Y, Nagoshi H, Shimura Y, Kobayashi T, Horiike S, Taniwaki M
- Journal Title
  
  Leukemia Res
  
  Volume: 38 Pages: 103-108
- Data Source
  KAKENHI-PROJECT-23591403
[Journal Article] 8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia.2014
- Author(s)
  Chinen Y, Sakamoto N, Nagoshi H, Taki T, Maegawa S, Tatekawa S, Tsukamoto T, Mizutani S, Shimura Y, Yamamoto-Sugitani M, Kobayashi T, Matsumoto Y, Horiike S, Kuroda J, Taniwaki M.
- Journal Title
  
  J Hematol Oncol
  
  Volume: 7 Issue: 1 Pages: 68-68
- DOI
  10.1186/s13045-014-0068-2
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591407, KAKENHI-PROJECT-25461432, KAKENHI-PROJECT-25860792
[Journal Article] FTY720 induces apoptosis of chronic myelogenous leukemia cells via dual activation of BIM and BID and overcomes various types of resistance to tyrosine kinase inhibitors2013
- Author(s)
  Kiyota M, Kuroda J, Yamamoto-Sugitani M, Shimura Y, Nakayama R, Nagoshi H, Mizutani S, Chinen Y, Sasaki N, Sakamoto N, Kobayashi T, Matsumoto Y, Horiike S, Taniwaki M
- Journal Title
  
  Apoptosis
  
  Volume: 18 Pages: 1437-46
- Data Source
  KAKENHI-PROJECT-23591403
[Journal Article] Multifaceted Mechanisms for Cell Survival in Chronic Myelogenous Leukemia2013
- Author(s)
  Kuroda J, Yamamoto M, Sasaki N, Taniwaki M
- Journal Title
  
  Curr Cancer Drug Targets
  
  Volume: 13 Pages: 69-79
- Data Source
  KAKENHI-PROJECT-23591403
[Journal Article] FTY720 induces apoptosis of chronic myelogenous leukemia cells via dual activation of BIM and BID and overcomes various types of resistance to tyrosine kinase inhibitors.2013
- Author(s)
  Kiyota M, Kuroda J, Yamamoto-Sugitani M, Shimura Y, Nakayama R, Nagoshi H, Mizutani S, Chinen Y, Sasaki N, Sakamoto N, Kobayashi T, Matsumoto Y, Horiike S, Taniwaki M.
- Journal Title
  
  Apoptosis
  
  Volume: 18 Issue: 11 Pages: 366-374
- DOI
  10.1007/s10495-013-0882-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591403, KAKENHI-PROJECT-25860792
[Journal Article] Editorial. The Innovative Decade of Molecular Targeted Therapy.2013
- Author(s)
  Kuroda J
- Journal Title
  
  Translational Medicine
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591403
[Journal Article] Multifaceted Mechanisms for Cell Survival in Chronic Myelogenous Leukemia.2013
- Author(s)
  Kuroda J, Yamamoto M, Sasaki N, Taniwaki M.
- Journal Title
  
  Curr Cancer Drug Targets
  
  Volume: 13 Pages: 69-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591403
[Journal Article] 慢性骨髄性白血病の薬剤耐性機構2012
- Author(s)
  黒田純也
- Journal Title
  
  Annual Review血液2013
  
  Volume: １ Pages: 99-108
- Data Source
  KAKENHI-PROJECT-23591403
[Journal Article] Editorial. The Innovative Decade of Molecular Targeted Therapy2012
- Author(s)
  Kuroda J
- Journal Title
  
  Transl Med 2012
- Data Source
  KAKENHI-PROJECT-23591403
[Journal Article] Galectin-3 induced by leukemia microenvironment promotes drug resistance and bone marrow lodgment in chronic myelogenous leukemia2011
- Author(s)
  Yamamoto-Sugitani M, Kuroda J, Ashihara E, Nagoshi H, Kobayashi T, Matsumoto Y, Sasaki N, Shimura Y, Kiyota M, Nakayama R, Akaji K, Taki T, Uoshima N, Kobayashi Y, Horiike S, Maekawa T, Taniwaki M
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 108 Pages: 17468-17473
- Data Source
  KAKENHI-PROJECT-23591403
[Journal Article] Galectin-3 induced by leukemia microenvironment promotes drug resistance and bone marrow lodgment in chronic myelogenous leukemia.2011
- Author(s)
  Yamamoto-Sugitani M, Kuroda J, Ashihara E, Nagoshi H, Kobayashi T, Matsumoto Y, et al.
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  Volume: 108 Pages: 17468-17473
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591403
[Journal Article] Principles and current topics concerning management of tyrosine kinase inhibitor therapy for chronic myelogenous leukemia2011
- Author(s)
  Kuroda J, Taniwaki M
- Journal Title
  
  Transl Med
- Data Source
  KAKENHI-PROJECT-23591403
[Journal Article] 慢性骨髄性白血病の細胞死の抑制2011
- Author(s)
  黒田純也、山本未央、谷脇雅史
- Journal Title
  
  血液内科
  
  Volume: 62(2) Pages: 159-165
- Data Source
  KAKENHI-PROJECT-23591403
[Journal Article] Anti-myeloma effect of Homoharringtonine with concomitant targeting of the myeloma-promoting molecules, Mc1-1, XIAP and 13-catenin2008
- Author(s)
  Kuroda J, et.al.
- Journal Title
  
  International Journal of Hematology 87
  
  Pages: 507-515
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790674
[Journal Article] JAK2V617F-positive essential thrombocythemia and multiple myeloma with IGH/CCND1 gene translocation co-exits, but originate from separate clones2008
- Author(s)
  Kuroda J, et.al.
- Journal Title
  
  Acta Haematologica 120
  
  Pages: 177-181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790674
[Journal Article] ABT-737 is a useful component of combinatory chemotherapies for chronic myelogenous leukaemias with diverse drug resistance mechanisms2008
- Author(s)
  Kuroda J
- Journal Title
  
  British Journa lo fHaematology 140
  
  Pages: 181-190
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790674
[Journal Article] ABT-737 is a useful component of combinatory chemotherapies for chronic myelogenous leukaemias with diverse drug resistance mechanisms.2008
- Author(s)
  Kuroda J, Kimura S,Andreeff M,Ashihara E, Kamitsuji Y, Yokota A, Kawata E, Takeuchi M, Tanaka R, Murotani Y, Matsumoto Y, Tanaka H, Strasser A, Taniwaki M, Maekawa T.
- Journal Title
  
  Br J Haematol 140
  
  Pages: 181-190
- Data Source
  KAKENHI-PROJECT-19790674
[Journal Article] The Bcr-Abl kinase inhibitor INNO-406 induces autophagy and different modes of cell death execution in Bcr-Abl-positive leukemias.2008
- Author(s)
  Kamitsuji Y, Kuroda J, Kimura S, Toyokuni S, Watanabe K, Ashihara E, Tanaka H, Yui Y, Watanabe M, Matsubara H, Mizushima Y, Hiraumi Y, Kawata E, Yoshikawa T, Maekawa T, Nakahata T, Adachi S.
- Journal Title
  
  Cell Death Differ 15
  
  Pages: 1712-1722
- Data Source
  KAKENHI-PROJECT-19790674
[Journal Article] Apoptosis-based dual molecular targeting by INNO-406,a second generation Bcr-Abl inhibitor,and ABT-737,an inhibitor of anti-apoptotic Bcl-2 proteins,against Bcr-Abl-positive leukemia2007
- Author(s)
  Kuroda J
- Journal Title
  
  Cell Death and Differentiation 14
  
  Pages: 1667-1677
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790674
[Journal Article] Apoptosis-based dual molecular targeting by INNO-406, a second generation Bcr-Abl inhibitor, and ABT-737, an inhibitor of anti-apoptotic Bcl-2 proteins, against Bcr-Abl-positive leukemia.2007
- Author(s)
  Kuroda J, Kimura S, Strasser A, Andreeff M, O'Reilly LA, Ashihara E, Kamitsuji Y, Yokota A, Kawata E, Takeuchi M, Tanaka R, Tabe Y, Taniwaki M, Maekawa T.
- Journal Title
  
  Cell Death Differ 14
  
  Pages: 1667-1677
- Data Source
  KAKENHI-PROJECT-19790674
[Journal Article] INNO-406, a novel BCR-ABL/Lyn dual tyrosine kinase inhibitor, suppresses the growth of Ph+ leukemia cells in the central nervous system and cyclosporine A augments its in vivo activity.2007
- Author(s)
  Yokota A, Kimura S, Masuda S, Ashihara E, Kuroda J, Sato K, Kamitsuji Y, Kawata E, Deguchi Y, Urasaki Y, Terui Y, Ruthardt M, Ueda T, Hatake K, Inui KI, Maekawa T.
- Journal Title
  
  Blood 109
  
  Pages: 306-314
- Data Source
  KAKENHI-PROJECT-19790674
[Presentation] RSK/AKT/S6Kトリプル阻害剤 TAS0612の抗骨髄腫効果2023
- Author(s)
  岡本明也、伊佐怜子、村松彩子、水原健太郎、民西(桂川)葉子、金山（川路）悠加、塚本　拓、志村勇司、水谷信介、黒田純也
- Organizer
  第48回日本骨髄腫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08512
[Presentation] 日常診療と形質細胞性腫瘍.2021
- Author(s)
  黒田純也
- Organizer
  日本内科学会近畿地方会生涯教育講演.
- Invited
- Data Source
  KAKENHI-PROJECT-19K08872
[Presentation] 多発性骨髄腫における分子腫瘍学的多様性の克服に向けて.2021
- Author(s)
  黒田純也
- Organizer
  千里ライフサイエンスセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19K08872
[Presentation] Expression of activated B cell gene signature is predictive for prognosis in follicular lymphoma2020
- Author(s)
  Tsukamoto T, Tokuda Y, Nakano N, Shimura Y, Kobayashi T, Horiike S, Tashiro K, Kuroda J
- Organizer
  第82回日本血液学会学術総会
- Data Source
  KAKENHI-PROJECT-19K08872
[Presentation] 多発性骨髄腫に対する分子標的治療戦略の理論とエビデンス2020
- Author(s)
  黒田純也
- Organizer
  第58回日本癌治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K08872
[Presentation] BUB1 overexpression may associate with karyotypic clonal evolution in multiple myeloma2020
- Author(s)
  Fujibayashi Y, Inada N，Kawasumi N，Ota S, Isa R, Yamaguchi J, Nishiyama D, Kimoto Y, Chinen Y, Shimura Y, Kobayashi T, Taniwaki M, Kuroda J
- Organizer
  第82回日本血液学会学術総会
- Data Source
  KAKENHI-PROJECT-19K08872
[Presentation] RSK2Ser227 in N-terminal kinase domain is a potential therapeutic target for mantle cell lymphoma2020
- Author(s)
  Kimoto Y, Tsukamoto T, Shimura Y, Chinen Y, Tanba K, Ota S, Fujibayashi Y, Nishiyama D, Isa R, 1，Yamaguchi J, Kanayama Y, Kobayashi T, Horiike S, Taniwaki M, Kuroda J
- Organizer
  第82回日本血液学会学術総会
- Data Source
  KAKENHI-PROJECT-19K08872
[Presentation] Clinical and functional significance of EWSR1 overexpression in multiple myeloma2020
- Author(s)
  Nishiyama D, Chinen Y, Fujibayashi Y, Isa R, Ota S, Kimoto Y, Yamaguchi J, Tsukamoto T, Shimura Y, Kobayashi T, Horiike S, Taniwaki M, Handa H, Kuroda J
- Organizer
  第82回日本血液学会学術総会
- Data Source
  KAKENHI-PROJECT-19K08872
[Presentation] The Abnormal Repression of Mir-375 Expression By Overlapping Epigenetic Dysregulations in Myelomas.2016
- Author(s)
  Tatekawa S, Chinen Y, Shimura Y, Matsumura-Kimoto Y, Nagoshi H, Kobayashi T, Kawata E, Narita T, Ri M, Handa H, Uoshima N, Iida S, Kuroda J.
- Organizer
  The American Society of Hematology 57th Annual Meeting and Exposition
- Place of Presentation
  SanDiego, USA
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461429
[Presentation] 多発性骨髄腫におけるmiR-375のエピジェネティック異常によるPDPK1発現亢進.2016
- Author(s)
  立川章太郎、知念良顕、志村勇司、名越久朗、古林　勉、木元弥生、河田英里、成田朋子、李　政樹、半田　寛、魚嶋伸彦、飯田真介、黒田純也.
- Organizer
  第41回日本骨髄腫学会学術集会
- Place of Presentation
  徳島、日本
- Year and Date
  2016-05-28
- Data Source
  KAKENHI-PROJECT-26461429
[Presentation] The epigenetic dysregulation of miR-375 for PDPK1 overexpression/activation in multiple myeloma.2016
- Author(s)
  Tatekawa S, Chinen Y, Shimura Y, Kimoto-Matsumura Y, Nagoshi H, Kobayashi T, Kawata E, Narita T, Ri M, Handa H, Uoshima N, Iida S, Kuroda J.
- Organizer
  第78回日本血液学会学術総会
- Place of Presentation
  横浜、日本
- Year and Date
  2016-10-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461429
[Presentation] The Epigenetic Repression of Mir-375 Is the Dominant Mechanism for the Constitutive Activation of PDPK1/RSK2 Signaling Axis in Multiple Myeloma.2015
- Author(s)
  Tatekawa S, Kuroda J, Chinen Y, Shimura Y, Nagoshi H, Kobayashi T, Kawata E, Uoshima N, Handa H, Taniwaki M.
- Organizer
  The American Society of Hematology 57th Annual Meeting and Exposition
- Place of Presentation
  米国
- Year and Date
  2015-12-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461429
[Presentation] 多発性骨髄腫におけるPDPK1発現の分子メカニズム.2015
- Author(s)
  立川章太郎、知念良顕、志村勇司、名越久朗、古林　勉、河田英里、魚嶋伸彦、半田　寛、黒田純也、谷脇雅史.
- Organizer
  第40回日本骨髄腫学会学術集会
- Place of Presentation
  熊本市
- Year and Date
  2015-05-16
- Data Source
  KAKENHI-PROJECT-26461429
[Presentation] 多発性骨髄腫におけるPDPK1の機能的・臨床的意義について.2015
- Author(s)
  知念良顕、黒田純也、志村勇司、名越久朗、李　政樹、河田英里、古林　勉、堀池重夫、飯田真介、谷脇雅史.
- Organizer
  第40回日本骨髄腫学会学術集会
- Place of Presentation
  熊本市
- Year and Date
  2015-05-16
- Data Source
  KAKENHI-PROJECT-26461429
[Presentation] The molecular mechanism of PDPK1 overexpression in multiple myeloma.2015
- Author(s)
  Tatekawa S, Chinen Y, Shimura Y, Nagoshi H, Kobayashi T, Kawata E, Uoshima N, Handa H, Kuroda J, Taniwaki M.
- Organizer
  第76回日本血液学会学術総会
- Place of Presentation
  金沢市
- Year and Date
  2015-10-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461429
[Presentation] Phosphoinositide-dependent protein kinase 1 is a crucial cell signaling mediator in multiple myeloma2014
- Author(s)
  Chinen Y, Kuroda J, Shimura Y, Nagoshi H, Kiyota M, Sugitani M, Mizutani S, Sakamoto N, Ri M, Kawata E, Kobayashi T, Matsumoto Y, Horiike S, Iida S, Taniwaki M.
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2014-11-01
- Data Source
  KAKENHI-PROJECT-25860792
[Presentation] PVT-1-NSMCE2 fusion gene enhances BCL-XL expression and drug resistance in leukemic cells.2014
- Author(s)
  Chinen Y, Sakamoto N, Nagoshi H, Taki T, Kobayashi S, Nishida K, Maegawa S, Kiyota M, Mizutani S, Shimura Y, Sugitani M, Kobayashi T, Matsumoto Y, Horiike S, Kuroda J, Taniwaki M.
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2014-10-31
- Data Source
  KAKENHI-PROJECT-25860792
[Presentation] Fingolimod (FTY720) Overcomes the Resistance to Tyrosine Kinase Inhibitors Via Dual Activation of BIM and BID in Chronic Myelogenous Leukemia The American Society of Hematology2012
- Author(s)
  Kiyota M, Kuroda J, Yamamoto-Sugitani M, Shimura Y, Nakayama R, Nagoshi H, Mizutani S, Chinen Y, Sakamoto N, Kobayashi T, Matsumoto Y, Horiike S, Taki T, Taniwaki M
- Organizer
  54th Annual Meeting and Exposition
- Data Source
  KAKENHI-PROJECT-23591403
[Presentation] Leukemia microenvironment-specific galectin-3 expression promotes drug resistance and bone marrow lodgment in chronic myelogenous leukemia2012
- Author(s)
  Yamamoto-Sugitani M, Kuroda J, Ashihara E, Nagoshi H, Kobayashi T, Matsumoto Y, Sasaki N, Shimura Y, Kiyota M, Nakayama R, Akaji K, Taki T, Uoshima N, Kobayashi Y, Horiike S, Maekawa T, Taniwaki M
- Organizer
  The 3^<rd> JSH International Symposium 2012
- Data Source
  KAKENHI-PROJECT-23591403
[Presentation] 慢性骨髄性白血病に対するチロシンキナーゼ阻害剤治療2012
- Author(s)
  黒田純也.
- Organizer
  第98回近畿血液学地方会
- Place of Presentation
  京都
- Invited
- Data Source
  KAKENHI-PROJECT-23591403
[Presentation] Fingolimod (FTY720) Overcomes the Resistance to Tyrosine Kinase Inhibitors Via Dual Activation of BIM and BID in Chronic Myelogenous Leukemia2012
- Author(s)
  Kiyota M, Kuroda J, Yamamoto-Sugitani M, Shimura Y, Nakayama R, Nagoshi H, Mizutani S, Chinen Y, Sakamoto N, Kobayashi T, Matsumoto Y, Horiike S, Taki T, Taniwaki M.
- Organizer
  The American Society of Hematology 54th Annual Meeting and Exposition
- Place of Presentation
  Atlanta, USA
- Data Source
  KAKENHI-PROJECT-23591403
[Presentation] Galectin-3 protects CML leukemic cells by antagonizing SERPINA1-albumin complex2012
- Author(s)
  Nakayama R, Kuroda J, Taniyama N, Wada S, Sugitani M, Shimura Y, Nagoshi H, Mizutani S, Chinen Y, Sakamoto N, Kobayashi T, Matsumoto Y, Horiike S, Sato K, Taniwaki M
- Organizer
  第74回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-23591403
[Presentation] Galectin-3 protects CML leukemic cells by antagonizing SERPINA1-albumin complex.2012
- Author(s)
  Nakayama R, Kuroda J, Taniyama N, Wada S, Sugitani M, Shimura Y, Nagoshi H, Mizutani S, Chinen Y, Sakamoto N, Kobayashi T, Matsumoto Y, Horiike S, Sato K, Taniwaki M.
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23591403
[Presentation] FTY720 induces apoptosis via both Bim-mediated intrinsic and extrinsic pathway in CML2012
- Author(s)
  Kiyota M, Kuroda J, Yamamoto-Sugitani M, Shimura Y, Nakayama R, Nagoshi H, Mizutani S, Chinen Y, Sakamoto N, Kobayashi T, Matsumoto Y, Horiike S, Taniwaki M
- Organizer
  第74回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-23591403
[Presentation] FTY720 induces apoptosis via both Bim-mediated intrinsic and extrinsic pathway in CML.2012
- Author(s)
  Kiyota M, Kuroda J, Yamamoto-Sugitani M, Shimura Y, Nakayama R, Nagoshi H, Mizutani S, Chinen Y, Sakamoto N, Kobayashi T, Matsumoto Y, Horiike S, Taniwaki M.
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23591403
[Presentation] 慢性骨髄性白血病に対するチロシンキナーゼ阻害剤治療2012
- Author(s)
  黒田純也
- Organizer
  第98回近畿血液学地方会
- Year and Date
  2012-12-01
- Data Source
  KAKENHI-PROJECT-23591403
[Presentation] Galectin-3 Is the Molecular Target for Overcoming Multidrug Resistance Due to the Cell Protection by Bone Marrow Leukemia Microenvironment in Chronic Myeloid Leukemia2011
- Author(s)
  Yamamoto M, Kuroda J, Kobayashi T, Sasaki N, Nagoshi H, Shimura Y, Kiyota M, Nakayama R, Horiike S, Ashihara E, Akaji K, Taniwaki M
- Organizer
  The American Society of Hematology 53rd Annual Meeting and Exposition
- Year and Date
  2011-12-11
- Data Source
  KAKENHI-PROJECT-23591403
[Presentation] Leukemia Microenvironment-Specific Galectin-3 Expression of Leukemic Cells Promotes Malignant Niche Formation and Bone Marrow Lodgment of Leukemic Cells in Chronic Myelogenous Leukemia2011
- Author(s)
  Kuroda J, Yamamoto M, Ashihara E, Nagoshi H, Kobayashi T, Matsumoto Y, Sasaki N, Shimura Y, Kiyota M, Nakayama R, Horiike S, Maekawa T, Taniwaki M
- Organizer
  The American Society of Hematology 53rd Annual Meeting and Exposition
- Year and Date
  2011-12-11
- Data Source
  KAKENHI-PROJECT-23591403
[Presentation] Leukemia Microenvironment-Specific Galectin-3 Expression of Leukemic Cells Promotes Malignant Niche Formation and Bone Marrow Lodgment of Leukemic Cells in Chronic Myelogenous Leukemia.2011
- Author(s)
  Kuroda J, Yamamoto M, Ashihara E, Nagoshi H, Kobayashi T, Matsumoto Y, Sasaki N, Shimura Y, Kiyota M, Nakayama R, Horiike S, Maekawa T, Taniwaki M.
- Organizer
  The American Society of Hematology 53rd Annual Meeting and Exposition
- Place of Presentation
  USA
- Data Source
  KAKENHI-PROJECT-23591403
[Presentation] Glyoxalase-I inhibition eliminates hypoxia-adapted CML cells resistant to imatinib, dasatinib, and INNO-406.2008
- Author(s)
  Takeuchi M , Kimura S, Kuroda J, Ashihara E, Kawatani M, Osada H, Umezawa K, Yasui E, Imoto M, Tsuruo T, Hodohara K, Nakahata T, Fujiyama Y, Maekawa T
- Organizer
  The American Society of Hematology 50th Annual Meeting and Exposition
- Place of Presentation
  San Francisco, Calfornia,USA
- Data Source
  KAKENHI-PROJECT-19790674
[Presentation] 低酸素環境適応性CML細胞に対するGlyoxalase-1阻害時の効果2008
- Author(s)
  武内美紀,黒田純也,上辻由里,木村晋也,芦原英司,程原佳子,藤山佳秀,川谷誠、長田裕之、安井英子,梅澤一夫,鶴尾隆、前川平
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19790674
[Presentation] Homoharringtonineのアポトーシス抵抗性分子多重阻害による抗骨髄腫効果2008
- Author(s)
  黒田純也, ら
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19790674
[Presentation] 新規Bcr-Abl阻害剤INNO-406とBcl-2阻害剤ABT-737の併用による慢性骨髄性白血病治療戦略.2007
- Author(s)
  黒田純也、木村晋也、芦原英司、前川平
- Organizer
  第11回がん分子標的治療研究会総会
- Place of Presentation
  大阪
- Year and Date
  2007-07-06
- Data Source
  KAKENHI-PROJECT-19790674
[Presentation] 白血病の分子標的治療とBcl-2ファミリー2007
- Author(s)
  黒田純也
- Organizer
  第69回日本血液学会総会・第49回日本臨床血液学会総会合同開催
- Place of Presentation
  横浜
- Year and Date
  2007-10-11
- Data Source
  KAKENHI-PROJECT-19790674
[Presentation] Glyoxalase-I Is a Potential Therapeutic Target for Chronic Myelogenous Leukemia Cells That Have Acquired Drug Resistancethrough Adaptation to Hypoxia.2007
- Author(s)
  Takeuchi M, Kuroda J, Kimura S, Ashihara E, Umezawa K, Yasui E, Kawatani M, Osada H, Hodohara K, Fujiyama Y, Maekawa T
- Organizer
  The 49th Annual Meeting of American Society of Hematology
- Place of Presentation
  Atlanta, Georgia, USA
- Data Source
  KAKENHI-PROJECT-19790674
[Presentation] 低酸素環境適応による慢性骨髄性白血病の治療抵抗性獲得機序とその克服.2007
- Author(s)
  武内美紀,黒田純也,木村晋也,芦原英司,上辻由里,程原佳子,藤山佳秀,安井英子,梅澤一夫,前川平
- Organizer
  第69回日本血液学会・第49回日本臨床血液学会・合同総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-13
- Data Source
  KAKENHI-PROJECT-19790674
[Presentation] 白血病の分子標的治療とBcl-2ファミリー2007
- Author(s)
  黒田純也
- Organizer
  第69回日本血液学会総会・第49回日本臨床血液学会総会合同開催
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-10-04
- Data Source
  KAKENHI-PROJECT-19790674
[Presentation] Phosphoinositide-dependent protein kinase 1 is a crucial cell signaling mediator in multiple myeloma.
- Author(s)
  Chinen Y, Kuroda J, Shimura Y, Nagoshi H, Kiyota M, Sugitani M, Mizutani S, Sakamoto N, Ri M, Kawata E, Kobayashi T, Matsumoto Y, Horiike S, Iida S, Taniwaki M.
- Organizer
  第76回日本血液学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-26461429
[Presentation] 3-Phosphoinositide-Dependent Protein Kinase 1 (PDPK1) Is a Pivotal Cell Signaling Mediator in Multiple Myeloma.
- Author(s)
  Chinen Y, Kuroda J, Shimura Y, Nagoshi H, Kiyota M, Yamamoto-Sugitani M, Mizutani S, Sakamoto N, Ri M, Kawata E, Kobayashi T, Matsumoto Y, Horiike S, Iida S, Taniwaki M.
- Organizer
  The American Society of Hematology 56th Annual Meeting and Exposition
- Place of Presentation
  San Fransisco, USA
- Year and Date
  2014-12-06 – 2014-12-09
- Data Source
  KAKENHI-PROJECT-26461429

1. SUGITANI Mio (60648749)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. TANIWAKI Masafumi (80163640)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 水谷信介 (40883088)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 塚本拓 (50825049)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 滝智彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Kuroda Junya 黒田 純也

JUNYA KURODA 黒田 純也

KURODA Junya 黒田 純也

Research Projects

Research Products

Co-Researchers

Generation of RSK2/AKT/S6K tripple inhibitor for mature lymphoid malignanciesPrincipal Investigator

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Drug discovery targeted against RSK2 in multiple myelomaPrincipal Investigator

Principal Investigator

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Review Section

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The functional involvement of PDPK1 in the pathophysiology of multiple myelomaPrincipal Investigator

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The mechanism of autocrine and paracrine growth promotion of CML cells

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Molecular and cellular effects of tumor microenvironment-specific Galectin-3 in leukemiaPrincipal Investigator

Principal Investigator

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Drug resistance mediated by hypoxic bone marrow leukemia environment in chronic myelogenous leukemiaPrincipal Investigator

Principal Investigator

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[Book] 造血器腫瘍アトラス改訂第５版2016

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[Book] 慢性骨髄性白血病の薬剤耐性機構. Annual Review血液20132013

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[Book] 慢性骨髄性白血病に対するチロシンキナーゼ阻害剤治療-知っておきたい基礎知識- BLOOD MASTER Vol.8「慢性骨髄性白血病」2011

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[Journal Article] The Rationale for the Dual-Targeting Therapy for RSK2 and AKT in Multiple Myeloma.2022

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[Journal Article] Expression of activated B cell gene signature is predictive of the outcome of follicular lymphoma.2022

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[Journal Article] Detection of novel and recurrent conjoined genes in non-Hodgkin B-cell lymphoma2021

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[Journal Article] EWSR1 overexpression is a pro-oncogenic event in multiple myeloma2021

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[Journal Article] Serine-227 in the N-terminal kinase domain of RSK2 is a potential therapeutic target for mantle cell lymphoma2020

Author(s)

Kuroda Junya 黒田純也

JUNYA KURODA 黒田純也

KURODA Junya 黒田純也