Tatsuta Takeo 立田岳生

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TATSUTA Takeo 立田岳生

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Researcher Number	70438563
Other IDs
Affiliation (Current)	2026: 東北医科薬科大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2021 – 2023: 東北医科薬科大学, 薬学部, 講師 2019: 東北医科薬科大学, 薬学部, 講師 2017 – 2018: 東北医科薬科大学, 薬学部, 助教 2014 – 2015: 東北薬科大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor therapeutics / Biological pharmacy
Keywords	Principal Investigator リボヌクレアーゼ / 抗腫瘍効果 / アポトーシス / RNA / シアル酸結合性レクチン / 抗がん剤 / 悪性中皮腫 / 多剤併用 / EGFR / AKR1B10 … More / 分子生物学 / 抗がん作用 / 抗腫瘍作用 / レクチン Less

Analysis of the antitumor effect of cSBL for the development of new anticancer drugPrincipal Investigator
- Principal Investigator
  
  Tatsuta Takeo
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
Development of new anticancer agents utilizing ribonucleasesPrincipal Investigator
- Principal Investigator
  
  Tatsuta Takeo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Tohoku Medical and Pharmaceutical University
Functional analysis of RNases as novel anti-cancer drugsPrincipal Investigator
- Principal Investigator
  
  TATSUTA Takeo
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku Pharmaceutical University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014

All Journal Article Presentation Book

[Book] Glycosignals in Cancer-Molecular assembly and recognition "Effects of Bullfrog sialic acid-binding lectin in cancer cells"2022
- Author(s)
  Takeo Tatsuta and Masahiro Hosono
- Total Pages
  23
- Publisher
  Springer Nature
- ISBN
  9789811977312
- Data Source
  KAKENHI-PROJECT-21K07198
[Journal Article] Sialidase NEU3 Contributes to the Invasiveness of Bladder Cancer2024
- Author(s)
  Tatsuta Takeo、Ito Jun、Yamamoto Koji、Sugawara Shigeki、Hosono Masahiro、Sato Makoto、Miyagi Taeko
- Journal Title
  
  Biomedicines
  
  Volume: 12 Issue: 1 Pages: 192-192
- DOI
  10.3390/biomedicines12010192
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15600, KAKENHI-PROJECT-21K07198, KAKENHI-PLANNED-24H00838
[Journal Article] Editorial: Drug-resistance in cancer cells: A new wine in an old bottle2023
- Author(s)
  Fonseca Leonardo Marques da、Tatsuta Takeo、Park Seung-Yeol、Freire-de-Lima Leonardo
- Journal Title
  
  Frontiers in Oncology
  
  Volume: 13
- DOI
  10.3389/fonc.2023.1161008
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07198
[Journal Article] Catfish Egg Lectin Enhances the Cytotoxicity of Sunitinib on Gb3-Expressing Renal Cancer Cells2023
- Author(s)
  Ito Jun、Sugawara Shigeki、Tatsuta Takeo、Hosono Masahiro、Sato Makoto
- Journal Title
  
  Biomedicines
  
  Volume: 11 Issue: 8 Pages: 2317-2317
- DOI
  10.3390/biomedicines11082317
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06581, KAKENHI-PROJECT-21K07198, KAKENHI-PROJECT-19K18619
[Journal Article] Discovery of antitumor effects of leczymes.2022
- Author(s)
  T. Tatsuta, M. Hosono
- Journal Title
  
  Glycoconj. J.
  
  Volume: 39 Issue: 2 Pages: 157-165
- DOI
  10.1007/s10719-021-10033-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07198
[Journal Article] Basic Research on Bullfrog Egg-derived Sialic Acid-binding Lectin for Cancer Treatment2022
- Author(s)
  Tatsuta Takeo
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 142 Issue: 10 Pages: 1045-1053
- DOI
  10.1248/yakushi.22-00116
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2022-10-01
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07198
[Journal Article] Transcriptomic alterations in malignant pleural mesothelioma cells in response to long-term treatment with bullfrog sialic-acid binding lectin.2021
- Author(s)
  T. Tatsuta, A. Nakasato, S. Sugawara, M. Hosono
- Journal Title
  
  Mol. Med. Rep.
  
  Volume: 23 Issue: 6
- DOI
  10.3892/mmr.2021.12106
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07198
[Journal Article] Sialic acid-binding lectin from bullfrog eggs inhibits human malignant mesothelioma cell growth in vitro and in vivo2018
- Author(s)
  Tatsuta Takeo、Satoh Toshiyuki、Sugawara Shigeki、Hara Akiyoshi、Hosono Masahiro
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 1 Pages: 0190653-0190653
- DOI
  10.1371/journal.pone.0190653
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15029
[Journal Article] Sialic Acid-Binding Lectin from Bullfrog Eggs Exhibits an Anti-Tumor Effect Against Breast Cancer Cells Including Triple-Negative Phenotype Cells.2018
- Author(s)
  Tatsuta T., Satoh S., Sato T., Sugawara S, Suzuki T., Hara A., Hosono M.
- Journal Title
  
  Molecules
  
  Volume: 23 (10) Issue: 10 Pages: 2714-2714
- DOI
  10.3390/molecules23102714
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15029
[Journal Article] 新規抗がん剤候補としてのレクザイムを用いた悪性中皮腫細胞に対する多剤併用効果の検討2017
- Author(s)
  佐藤稔之、立田岳生、菅原栄紀、原明義、細野雅祐
- Journal Title
  
  東北医科薬科大学研究誌
  
  Volume: 64 Pages: 65-76
- NAID
  120006543102
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15029
[Journal Article] Synergistic anti-tumor effect of bullfrog sialic acid-binding lectin and pemetrexed in malignant mesothelioma2017
- Author(s)
  Satoh Toshiyuki、Tatsuta Takeo、Sugawara Shigeki、Hara Akiyoshi、Hosono Masahiro
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 26 Pages: 42466-42477
- DOI
  10.18632/oncotarget.17198
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15029
[Journal Article] 抗腫瘍性リボヌクレアーゼの現状と展望2014
- Author(s)
  細野雅祐, 立田岳生
- Journal Title
  
  東北薬科大学研究誌
  
  Volume: 61 Pages: 11-25
- NAID
  110009899351
- Open Access
- Data Source
  KAKENHI-PROJECT-26870527
[Journal Article] Cancer-selective induction of apoptosis by leczyme2014
- Author(s)
  Tatsuta Takeo, Sugawara Shigeki, Takahashi Kohta, Ogawa Yukiko, Hosono Masahiro, Nitt, Kazuo
- Journal Title
  
  Frontiers in oncology
  
  Volume: 2014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26870527
[Presentation] シアリダーゼNEU3は膀胱がんの浸潤性に寄与する2024
- Author(s)
  立田岳生、伊藤淳、山本晃司、菅原栄紀、細野雅祐、宮城妙子
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K07198
[Presentation] がん細胞内でグロボトリアオシルセラミド（Gb3）が影響する因子の探索2023
- Author(s)
  菊地聡大，菅原栄紀，立田岳生，細野雅祐
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K07198
[Presentation] Research on a leczyme as a candidate of novel anticancer drug2023
- Author(s)
  Takeo Tatsuta
- Organizer
  第２回東北医科薬科大学・台湾アカデミアシニカ合同シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07198
[Presentation] DOX および cSBL によるAKR1B10発現調節機構の調査2023
- Author(s)
  佐藤彬翔，立田岳生，渡部史哉，菅原栄紀，細野雅祐
- Organizer
  第62回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-21K07198
[Presentation] ラトロフィリンに存在するレクチン様ドメインの機能解析2023
- Author(s)
  菅原栄紀，菊地聡大，立田岳生，細野雅祐
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K07198
[Presentation] Gb3 により調節されるシスプラチン感受性に関与する分子の探索2023
- Author(s)
  菊地聡大, 菅原栄紀，立田岳生，細野雅祐
- Organizer
  第17回東北糖鎖研究会
- Data Source
  KAKENHI-PROJECT-21K07198
[Presentation] JNK および p38 の活性化が悪性中皮腫に対する cSBL 誘導アポトーシスに関与する2023
- Author(s)
  佐藤彬翔，立田岳生，菅原栄紀，細野雅祐
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K07198
[Presentation] cSBL誘導性EGFR発現減少のメカニズム解析2023
- Author(s)
  立田岳生，佐藤祥子，菅原栄紀，細野雅祐,
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K07198
[Presentation] 細胞内膜系Gb3 は抗がん剤によるアポトーシスに関与する2022
- Author(s)
  菊地聡大, 菅原栄紀, 叶江利花, 立田岳生, 細野雅祐
- Organizer
  第16回東北糖鎖研究会
- Data Source
  KAKENHI-PROJECT-21K07198
[Presentation] 悪性中皮腫細胞における多剤耐性輸送体への cSBL の影響2022
- Author(s)
  中里ありす，立田岳生，菅原栄紀，細野雅祐
- Organizer
  第61回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-21K07198
[Presentation] HeLa細胞におけるナマズ卵レクチンの細胞内輸送機構の解明2022
- Author(s)
  菅原栄紀, 菊地聡大, 立田岳生, 細野雅祐
- Organizer
  第41回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-21K07198
[Presentation] 悪性中皮腫細胞に発現するAKR1B10およびABCC2に対するcSBLの効果2022
- Author(s)
  立田岳生、中里ありす、佐藤彬翔、菅原栄紀、細野雅祐
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K07198
[Presentation] 悪性中皮腫細胞およびそのRNase 耐性細胞における ABC トランスポーターの発現に対する cSBL の影響2022
- Author(s)
  中里ありす，立田岳生，菅原栄紀，細野雅祐
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K07198
[Presentation] Gb3分子種によるナマズ卵レクチンのがん細胞に対する多様な効果2022
- Author(s)
  菅原栄紀，菊地聡大，立田岳生，細野雅祐
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K07198
[Presentation] AKR1B10 に対する cSBL の効果とそのメカニズムの調査2022
- Author(s)
  佐藤彬翔，立田岳生，田口有里佳，菅原栄紀，細野雅祐
- Organizer
  第61回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-21K07198
[Presentation] 膀胱がん細胞に対するcSBL の抗腫瘍効果について2021
- Author(s)
  立田岳生、中里ありす、菅原栄紀、伊藤淳、佐藤信、細野雅祐
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K07198
[Presentation] 悪性中皮腫細胞のウシガエル卵由来シアル酸結合レクチン処理におけるトランスクリプトーム解析2021
- Author(s)
  立田岳生、菅原栄紀、細野雅祐
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07198
[Presentation] 確立された RNase 耐性がん細胞における AKR1B10 と ABCC2 の発現に対する cSBL の影響2021
- Author(s)
  中里ありす、立田岳生、菅原栄紀、細野雅祐
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K07198
[Presentation] がん治療への応用を目指したウシガエル卵由来シアル酸結合性レクチン(cSBL) の基礎研究2021
- Author(s)
  立田岳生
- Organizer
  第４３回東北薬学セミナー
- Data Source
  KAKENHI-PROJECT-21K07198
[Presentation] cSBLはAKR1B10 の発現を減少させる2020
- Author(s)
  立田岳生，菅原栄紀，細野雅祐
- Organizer
  日本薬学会年会第140年会
- Data Source
  KAKENHI-PROJECT-17K15029
[Presentation] cSBL 耐性細胞における遺伝子発現変化2019
- Author(s)
  立田岳生，菅原栄紀，細野雅祐
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K15029
[Presentation] Bullfrog sialic acid-binding lectin reduces the expression of EGF receptors in cancer cells2019
- Author(s)
  Tatsuta T., Sato S., Sugawara S., Hosono M.
- Organizer
  25th International Symposium on Glycoconjugates
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15029
[Presentation] シアル酸結合性レクチン (cSBL) は乳がん細胞に ER，PgR および HER family タンパクの減少を伴う細胞死を誘導する2019
- Author(s)
  佐藤祥子，立田岳生，佐藤稔之，菅原栄紀，鈴木常義，細野雅祐
- Organizer
  第40回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-17K15029
[Presentation] 新規悪性中皮腫治療薬の開発を目指したウシガエル卵由来シアル酸結合性レクチン (cSBL) の応用研究2018
- Author(s)
  立田岳生，佐藤稔之，菅原栄紀，細野雅祐
- Organizer
  生化学会東北支部第84回例会
- Data Source
  KAKENHI-PROJECT-17K15029
[Presentation] シアル酸結合性レクチン（cSBL）のEGFR pathwayへの影響2018
- Author(s)
  佐藤稔之，立田岳生，菅原栄紀，原明義、細野雅祐
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K15029
[Presentation] Sialic Acid-Binding Lectin from Bullfrog Eggs Exhibits an Anti-Tumor Effect Against Breast Cancer Cells2018
- Author(s)
  立田岳生，佐藤祥子，佐藤稔之，菅原栄紀，鈴木常義，細野雅祐
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K15029
[Presentation] 悪性中皮腫に対するシアル酸結合性レクチン (cSBL) と他剤との併用効果2017
- Author(s)
  佐藤稔之，立田岳生，菅原栄紀，原明義，細野雅祐
- Organizer
  第90回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K15029
[Presentation] 悪性中皮腫に対するレクザイムの in vivo における抗腫瘍効果およびペメトレキセドとの併用効果2017
- Author(s)
  立田岳生，佐藤稔之，細野雅祐
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K15029
[Presentation] 悪性中皮腫に対し cSBL とペメトレキセドの併用は相乗的に抗腫瘍効果を示す2016
- Author(s)
  佐藤稔之, 立田岳生, 菅原栄紀, 菅野秀一, 細野雅祐
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜　（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26870527
[Presentation] 悪性胸膜中皮腫に対するウシガエル卵由来シアル酸結合性レクチン（cSBL）とペメトレキセドの併用効果について2015
- Author(s)
  佐藤稔之, 立田岳生, 菅原栄紀, 菅野秀一, 細野雅祐
- Organizer
  第9回東北糖鎖研究会
- Place of Presentation
  東北薬科大学　（宮城県仙台市）
- Year and Date
  2015-09-04
- Data Source
  KAKENHI-PROJECT-26870527
[Presentation] Anti-cancer effect induced by cSBL possessing lectin and ribonuclease activities2015
- Author(s)
  Tatsuta T, Sato T, Sugawara S, Kanno S, Hosono M,
- Organizer
  7th Asia Community of Glycoscience and Glycotechnology Conference
- Place of Presentation
  ホテル大観荘　(宮城県仙台市）
- Year and Date
  2015-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26870527
[Presentation] レクチン活性とリボヌクレアーゼ活性を併せ持つcSBLによる抗腫瘍効果の作用機序解析2015
- Author(s)
  立田岳生, 高橋耕太, 細野雅祐
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場　（愛知県名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26870527
[Presentation] A leczyme which has both lectin and ribonuclease activity causes a cancer-selective induction of apoptosis2014
- Author(s)
  Tatsuta T., Sugawara S., Takahashi K., Hosono M.
- Organizer
  19th World Congress on Advances in Oncology and 17th International Symposium on Molecular Medicine
- Place of Presentation
  Athens (Greece)
- Year and Date
  2014-10-11
- Invited
- Data Source
  KAKENHI-PROJECT-26870527
[Presentation] レクザイムによるがん細胞選択的なアポトーシス誘導効果について2014
- Author(s)
  立田岳生，高橋耕太，細野雅祐
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜 (神奈川県横浜市）
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-26870527

1. 山本晃司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 菅原栄紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tatsuta Takeo 立田 岳生

TATSUTA Takeo 立田 岳生

Research Projects

Research Products

Co-Researchers

Analysis of the antitumor effect of cSBL for the development of new anticancer drugPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new anticancer agents utilizing ribonucleasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of RNases as novel anti-cancer drugsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Glycosignals in Cancer-Molecular assembly and recognition "Effects of Bullfrog sialic acid-binding lectin in cancer cells"2022

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Sialidase NEU3 Contributes to the Invasiveness of Bladder Cancer2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Editorial: Drug-resistance in cancer cells: A new wine in an old bottle2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Catfish Egg Lectin Enhances the Cytotoxicity of Sunitinib on Gb3-Expressing Renal Cancer Cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Discovery of antitumor effects of leczymes.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Basic Research on Bullfrog Egg-derived Sialic Acid-binding Lectin for Cancer Treatment2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Transcriptomic alterations in malignant pleural mesothelioma cells in response to long-term treatment with bullfrog sialic-acid binding lectin.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sialic acid-binding lectin from bullfrog eggs inhibits human malignant mesothelioma cell growth in vitro and in vivo2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sialic Acid-Binding Lectin from Bullfrog Eggs Exhibits an Anti-Tumor Effect Against Breast Cancer Cells Including Triple-Negative Phenotype Cells.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 新規抗がん剤候補としてのレクザイムを用いた悪性中皮腫細胞に対する多剤併用効果の検討2017

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Synergistic anti-tumor effect of bullfrog sialic acid-binding lectin and pemetrexed in malignant mesothelioma2017

Author(s)

Journal Title

Tatsuta Takeo 立田岳生

TATSUTA Takeo 立田岳生