Kobayashi Hidetomo 小林秀丈

… Alternative Names

KOBAYASHI Hidetomo 小林秀丈

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Researcher Number	70441574
Other IDs	https://orcid.org/0000-0002-5918-4268
Affiliation (Current)	2024: 広島国際大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2020 – 2022: 広島国際大学, 薬学部, 講師 2016 – 2018: 広島国際大学, 薬学部, 講師 2007 – 2008: Hiroshima International University, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 49050:Bacteriology-related / Environmental and hygienic pharmacy / Bacteriology (including Mycology) Except Principal Investigator Basic Section 58010:Medical management and medical sociology-related / Medical and hospital managemen
Keywords	Principal Investigator Aeromonas / 腸管感染 / 糖鎖認識 / 腸管感染症 / 細菌感染症 / 接着 / 糖脂質 / 腸管上皮 / 組織浸潤 / 病原因子 … More / 細菌性食中毒 / 微生物・感染症学 / 分子疫学 / 基質特異性 / 上皮バリア / プロテアーゼ / 微生物 / 酵素 / 毒素 / 細菌 / 成熟化 / セリンプロテアーゼ / アエロモナス … More Except Principal Investigator 分子疫学 / 薬剤耐性菌 / 院内感染管理 / 薬剤耐性 / 抗菌薬使用数量 / メチシリン耐性黄色ブドウ球菌 / 抗菌薬 / 院内感染制御 / 病院・医療管理学 Less

地域圏における抗菌薬使用数量や薬剤耐性菌の疫学解析が抗菌薬適正使用に与える影響
- Principal Investigator
  
  佐和章弘
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58010:Medical management and medical sociology-related
- Research Institution
  Hiroshima International University
Analysis of glycolipid recognition mechanism in intestinal tissue invasion of Aeromonas and its application studyPrincipal Investigator
- Principal Investigator
  
  Kobayashi Hidetomo
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Hiroshima International University
Molecular epidemiological analysis for methicillin-resistant Staphylococcus aureus (MRSA) isolated in the hospitals in Kure District, Hiroshima
- Principal Investigator
  
  Sawa Akihiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical and hospital managemen
- Research Institution
  Hiroshima International University
The role of Aeromonas sobria serine protease in the Aeromonas infection and its molecular epidemiological analysisPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Hidetomo
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Hiroshima International University
Role of the Carboxy-terminal Region in Maturation of Aeromonas sobria Serine ProteasePrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Hidetomo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Hiroshima International University

All 2023 2022 2021 2020 2019 2017 2016 2009 2008 2007

All Journal Article Presentation

[Journal Article] Aeromonas sobria Serine Protease Degrades Several Protein Components of Tight Junctions and Assists Bacterial Translocation Across the T84 Monolayer2022
- Author(s)
  Ueda Mitsunobu、Kobayashi Hidetomo、Seike Soshi、Takahashi Eizo、Okamoto Keinosuke、Yamanaka Hiroyasu
- Journal Title
  
  Frontiers in Cellular and Infection Microbiology
  
  Volume: 12 Pages: 824547-824547
- DOI
  10.3389/fcimb.2022.824547
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16255, KAKENHI-PROJECT-20K07504
[Journal Article] Molecular epidemiological and pharmaceutical studies of methicillin-resistant Staphylococcus aureus isolated at hospitals in Kure City, Japan2022
- Author(s)
  Maeda Ryuto、Kobayashi Hidetomo、Higashidani Mami、Matsuhisa Tetsuaki、Sawa Akihiro、Miyake Katsushi、Tayama Yoshitaka、Kimura Kouji、Itoh Hiroyuki、Okano Taichi、Seike Soshi、Yamanaka Hiroyasu
- Journal Title
  
  Access Microbiology
  
  Volume: 4 Issue: 2 Pages: 000319-000319
- DOI
  10.1099/acmi.0.000319
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16255, KAKENHI-PROJECT-20K07504, KAKENHI-PROJECT-22K10431
[Journal Article] Outer Membrane Vesicles Released From Aeromonas Strains Are Involved in the Biofilm Formation2021
- Author(s)
  Seike Soshi、Kobayashi Hidetomo、Ueda Mitsunobu、Takahashi Eizo、Okamoto Keinosuke、Yamanaka Hiroyasu
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 11 Pages: 613650-613650
- DOI
  10.3389/fmicb.2020.613650
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07504, KAKENHI-PROJECT-20K16255
[Journal Article] Involvement of the Arg566 residue of Aeromonas sobria serine protease in substrate specificity.2017
- Author(s)
  Kobayashi H, Otsubo T, Teraoka F, Ikeda K, Seike S, Takahashi E, Okamoto K, Yoshida T, Tsuge H, Yamanaka H
- Journal Title
  
  PLoS One
  
  Volume: - Issue: 10 Pages: e0186392-e0186392
- DOI
  10.1371/journal.pone.0186392
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08289, KAKENHI-PROJECT-16K18926
[Journal Article] Production of C5a by ASP, a serine protease released from Aeromonas sobria2008
- Author(s)
  Hidetoshi Nitta, Takahisa Imamura, Yoshihiro Wada, Atsushi Irie, Hidetomo Kobayashi, Keinosuke Okamoto, and Hideo Baba
- Journal Title
  
  The Journal of Immunology 181
  
  Pages: 3602-3608
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890254
[Journal Article] MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II2008
- Author(s)
  Hiroyasu Yamanaka, Hidetomo Kobayashi, Eizo Takahashi, and Keinosuke Okamoto
- Journal Title
  
  Jounal of Bacteriology 190
  
  Pages: 7693-7698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890254
[Journal Article] Impaired plasma clottability induction through fibrinogen degradation by ASP, a serine protease released from Aeromonas sobria2008
- Author(s)
  Takahisa Imamura, Hidetoshi Nitta, Yoshihiro Wada, Hidetomo Kobayashi and Keinosuke Okamoto
- Journal Title
  
  FEMS Microbiology Letters 284
  
  Pages: 35-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890254
[Journal Article] Activation of prothrombin by ASP, a serine protease released from Aeromonas sobria2007
- Author(s)
  Hidetoshi Nitta, Hidetomo Kobayashi, Atsushi Irie, Hideo Baba, Keinosuke Okamoto, Takahisa Imamura
- Journal Title
  
  FEBS Letters 581
  
  Pages: 5935-5939
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890254
[Presentation] Aeromonasセリンプロテアーゼのタイトジャンクションの破壊は菌の感染により増強される2023
- Author(s)
  小林秀丈、清家総史、高橋栄造、岡本敬の介、山中浩泰
- Organizer
  第96回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-20K07504
[Presentation] Aeromonasの組織侵襲における糖脂質認識機構の解析2023
- Author(s)
  森海基、小林秀丈、清家総史、高橋栄造、岡本敬の介、山中浩泰
- Organizer
  日本薬学会　第143年会
- Data Source
  KAKENHI-PROJECT-20K07504
[Presentation] Aeromonasの細胞接着における糖脂質認識機構の解析2022
- Author(s)
  森海基、小林秀丈、清家総史、高橋栄造、岡本敬の介、山中浩泰
- Organizer
  第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-20K07504
[Presentation] Aeromonas の腸管上皮バリア破壊機構の解析2022
- Author(s)
  小林秀丈、清家総史、高橋栄造、岡本敬の介、山中浩泰
- Organizer
  第75回日本細菌学会中国・四国支部総会
- Data Source
  KAKENHI-PROJECT-20K07504
[Presentation] Aeromonas sobria セリンプロテアーゼのタイトジャンクション破壊機構の解析2021
- Author(s)
  小林秀丈、上田充展、清家総史、高橋栄造、岡本敬の介、山中浩泰
- Organizer
  第74回日本細菌学会中国・四国支部総会
- Data Source
  KAKENHI-PROJECT-20K07504
[Presentation] Aeromonasセリンプロテアーゼのタイトジャンクションの破壊は菌の上皮バリア透過を引き起こす2021
- Author(s)
  小林秀丈、清家総史、高橋栄造、岡本敬の介、山中浩泰
- Organizer
  第95回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-20K07504
[Presentation] Aeromonas hydrophilaのマクロファージ内生存に関する研究2021
- Author(s)
  小林秀丈、清家総史、上田充展、高橋栄造、岡本敬の介、山中浩泰
- Organizer
  第67回トキシンシンポジウム
- Data Source
  KAKENHI-PROJECT-20K07504
[Presentation] Aeromonasセリンプロテアーゼによる腸管上皮細胞バリア破壊機構の解析2020
- Author(s)
  上田充展、小林秀丈、清家総史、高橋栄造、岡本敬の介、山中浩泰
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K07504
[Presentation] Aeromonasセリンプロテーアーゼによる腸管上皮細胞バリア破壊機構の解析2020
- Author(s)
  上田充展、小林秀丈、清家総史、高橋栄造、岡本敬の介、山中浩泰
- Organizer
  第59回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-20K07504
[Presentation] Aeromonas hydrophilaのマクロファージ内生存に関する研究2020
- Author(s)
  小林秀丈、清家総史、上田充展、高橋栄造、岡本敬の介、山中浩泰
- Organizer
  第73回日本細菌学会中国・四国支部総会
- Data Source
  KAKENHI-PROJECT-20K07504
[Presentation] Aeromonas serine protease disrupts epithelial junctions and contributes to bacterial translocation2020
- Author(s)
  Hidetomo Kobayashi、Soshi Seike、Eizo Takahashi、Keinosuke Okamoto and Hiroyasu Yamanaka
- Organizer
  第94回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-20K07504
[Presentation] 呉地区の医療施設で分離されたメチシリン耐性黄色ブドウ球菌（MRSA）の分子疫学解析2019
- Author(s)
  前田龍人、小林秀丈、吉崎瑞穂、佐和章弘、岡野太一、木村幸司、清家総史、山中浩泰
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16K09194
[Presentation] Aeromonasの菌体外プロテアーゼによる腸上皮バリア破壊機構の解析とその産生機構に関する研究2017
- Author(s)
  小林秀丈、清家総史、高橋栄造、岡本敬の介、山中浩泰
- Organizer
  64回トキシンシンポジウム
- Data Source
  KAKENHI-PROJECT-16K18926
[Presentation] Aeromonasの産生する菌体外プロテアーゼの産生機構に関する研究2017
- Author(s)
  甲斐雄貴、小林秀丈、清家総史、吉田徹、宮川拓也、田代充、高橋栄造、岡本敬の介、津下英明、田之倉優、山中浩泰
- Organizer
  第56回日本薬学会・日本病院薬剤師会中国・四国支部学術大会
- Data Source
  KAKENHI-PROJECT-16K18926
[Presentation] Aeromonas属菌の組織侵入機構の解析2017
- Author(s)
  清家総史、小林秀丈、高橋栄造、岡本敬の介、山中浩泰
- Organizer
  第70回日本細菌学会中国・四国支部総会
- Data Source
  KAKENHI-PROJECT-16K18926
[Presentation] Involvement of the Arg-566 residue of Aeromonas sobria serine protease in substrate specificity2017
- Author(s)
  Hidetomo Kobayashi, Tadamune Otsubo, Fumiteru Teraoka, Kiyoshi Ikeda, Soshi Seike, Eizo Takahashi, Keinosuke Okamoto, Toru Yoshida, Hideaki Tsuge, and Hiroyasu Yamanaka
- Organizer
  第91回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-16K18926
[Presentation] Aeromonasの組織侵入に関わる菌体外プロテアーゼの役割2017
- Author(s)
  古田典滉、小林秀丈、清家総史、高橋栄造、岡本敬の介、山中浩泰
- Organizer
  第56回日本薬学会・日本病院薬剤師会中国・四国支部学術大会
- Data Source
  KAKENHI-PROJECT-16K18926
[Presentation] Aeromonasセリンプロテアーゼによる腸管上皮バリア破壊機構の解析2016
- Author(s)
  小林秀丈、高橋栄造、岡本敬の介、山中浩泰
- Organizer
  第28回微生物シンポジウム
- Place of Presentation
  愛知学院大学
- Year and Date
  2016-09-02
- Data Source
  KAKENHI-PROJECT-16K18926
[Presentation] Aeromonas sobriaセリンプロテアーゼの成熟化機構の解析2009
- Author(s)
  小林秀丈
- Organizer
  日本薬学会第129年会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-19890254
[Presentation] Aeromonas sobriaセリンプロテアーゼの成熟化機構の解析2009
- Author(s)
  小林秀丈
- Organizer
  第82回日本細菌学会総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2009-03-13
- Data Source
  KAKENHI-PROJECT-19890254
[Presentation] アエロモナスセリンプロテアーゼの成熟化におけるC末端領域の役割2008
- Author(s)
  小林秀丈
- Organizer
  第81回日本細菌学会総会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2008-03-24
- Data Source
  KAKENHI-PROJECT-19890254
[Presentation] Aeromonas sobriaの産生するセリンプロテアーゼの成熟化機構の解析2008
- Author(s)
  小林秀丈
- Organizer
  第55回毒素シンポジウム
- Place of Presentation
  ラフォーレ山中湖
- Year and Date
  2008-07-02
- Data Source
  KAKENHI-PROJECT-19890254
[Presentation] Aeromonas sobriaセリンプロテアーゼの成熟化メカニズム2008
- Author(s)
  小林秀丈
- Organizer
  第31回日本部分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸国際展示場
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-19890254
[Presentation] Aeromonas sobriaセリンプロテアーゼの成熟化メカニズム2008
- Author(s)
  小林秀丈
- Organizer
  第61回日本細菌学会中国・四国支部総会
- Place of Presentation
  愛媛大学
- Year and Date
  2008-10-18
- Data Source
  KAKENHI-PROJECT-19890254
[Presentation] Aeromonas sobriaの産生するセリンプロテアーゼに関する研究2007
- Author(s)
  小林秀丈
- Organizer
  第54回毒素シンポジウム
- Place of Presentation
  犬鳴グランドホテル紀泉閣
- Year and Date
  2007-09-06
- Data Source
  KAKENHI-PROJECT-19890254
[Presentation] アエロモナスセリンプロテアーゼの構造とC末端領域の機能に関する研究2007
- Author(s)
  小林秀丈
- Organizer
  第46回日本薬学会中国四国支部学術大会
- Place of Presentation
  高知市文化プラザ「カルポート」
- Year and Date
  2007-11-11
- Data Source
  KAKENHI-PROJECT-19890254
[Presentation] Aeromonas sobriaの産生するセリンプロテアーゼに関する研究2007
- Author(s)
  小林秀丈
- Organizer
  第54回毒棄シンポジウム
- Place of Presentation
  大阪府泉佐野市犬鳴グランドホテル紀泉閣
- Year and Date
  2007-09-06
- Data Source
  KAKENHI-PROJECT-19890254
[Presentation] アエロモナスセリンプロテアーゼの構造とC末鞭聖機能に関する研究2007
- Author(s)
  小林秀丈
- Organizer
  第46回日本薬学会中国四国支部学術大会
- Place of Presentation
  高知市文化プラザ「カルポート」
- Year and Date
  2007-11-11
- Data Source
  KAKENHI-PROJECT-19890254

1. Sawa Akihiro (70389104)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. 山中浩泰 (30202386)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 木村幸司 (90389106)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. 清家総史 (90806275)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 津下英明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 吉田徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kobayashi Hidetomo 小林 秀丈

KOBAYASHI Hidetomo 小林 秀丈

Research Projects

Research Products

Co-Researchers

地域圏における抗菌薬使用数量や薬剤耐性菌の疫学解析が抗菌薬適正使用に与える影響

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of glycolipid recognition mechanism in intestinal tissue invasion of Aeromonas and its application studyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular epidemiological analysis for methicillin-resistant Staphylococcus aureus (MRSA) isolated in the hospitals in Kure District, Hiroshima

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of Aeromonas sobria serine protease in the Aeromonas infection and its molecular epidemiological analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of the Carboxy-terminal Region in Maturation of Aeromonas sobria Serine ProteasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Aeromonas sobria Serine Protease Degrades Several Protein Components of Tight Junctions and Assists Bacterial Translocation Across the T84 Monolayer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular epidemiological and pharmaceutical studies of methicillin-resistant Staphylococcus aureus isolated at hospitals in Kure City, Japan2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Outer Membrane Vesicles Released From Aeromonas Strains Are Involved in the Biofilm Formation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Involvement of the Arg566 residue of Aeromonas sobria serine protease in substrate specificity.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Production of C5a by ASP, a serine protease released from Aeromonas sobria2008

Author(s)

Journal Title

Data Source

[Journal Article] MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II2008

Author(s)

Journal Title

Data Source

[Journal Article] Impaired plasma clottability induction through fibrinogen degradation by ASP, a serine protease released from Aeromonas sobria2008

Author(s)

Journal Title

Data Source

[Journal Article] Activation of prothrombin by ASP, a serine protease released from Aeromonas sobria2007

Author(s)

Journal Title

Data Source

[Presentation] Aeromonasセリンプロテアーゼのタイトジャンクションの破壊は菌の感染により増強される2023

Author(s)

Organizer

Data Source

[Presentation] Aeromonasの組織侵襲における糖脂質認識機構の解析2023

Author(s)

Organizer

Data Source

[Presentation] Aeromonasの細胞接着における糖脂質認識機構の解析2022

Kobayashi Hidetomo 小林秀丈

KOBAYASHI Hidetomo 小林秀丈

[Presentation] Aeromonasセリンプロテアーゼのタイトジャンクションの破壊は菌の上皮バリア透過を引き起こす2021