HIROKI Iwai 祝弘樹

Researcher Number	70443116
Affiliation (based on the past Project Information) *help	2016 – 2017: 国立研究開発法人国立国際医療研究センター, その他部局等, 研究員(移行) 2015: 国立研究開発法人国立国際医療研究センター, その他部局等, 研究員 2013 – 2014: 独立行政法人国立国際医療研究センター, その他部局等, 研究員
Review Section/Research Field	Principal Investigator Bacteriology (including mycology)
Keywords	Principal Investigator 結核菌 / PE_PGRS62 / 細菌 / lamellar body / ABCA3 / M. tuberculosis / CD63 / LC3 / オートファジー

創薬にむけた結核菌膜タンパク質の親水性膜外領域に結合するペプチドの探索Principal Investigator
- Principal Investigator
  
  祝弘樹
- Project Period (FY)
  2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  National Center for Global Health and Medicine
Biogenesis of lamellar body-like organelles in host cells expressing Mycobacterium tuberculosis PE_PGRS62Principal Investigator
- Principal Investigator
  
  Iwai Hiroki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  National Center for Global Health and Medicine
The role of PE_PGRS62 in autophagosome formation by Mycobacterium tuberculosisPrincipal Investigator
- Principal Investigator
  
  HIROKI Iwai
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Research Institute, International Medical Center of Japan

All 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Peroxiredoxin 1 Contributes to Host Defenses against Mycobacterium tuberculosis.2016
- Author(s)
  Matsumura K, Iwai H, Kato-Miyazawa M, Kirikae F, Zhao J, Yanagawa T, Ishii T, Miyoshi-Akiyama T, Funatogawa K, Kirikae T.
- Journal Title
  
  Journal of Immunology
  
  Volume: 197(8) Pages: 3233-3244
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19102
[Journal Article] A mutation in the decoding region of 16S rRNA attenuates the virulence of Mycobacterium tuberculosis.2016
- Author(s)
  Watanabe, S., Matsumura, K., Iwai, H., Funatogawa, K., Haishima, Y., Fukui, C., Okumura, K., Kato, M., Hashimoto, M., Teramoto, K., Kirikae, F., Miyoshi-Akiyama, T., and Kirikae, T.
- Journal Title
  
  Infection and Immunity.
  
  Volume: 84 Issue: 8 Pages: 2264-2273
- DOI
  10.1128/iai.00417-16
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05654, KAKENHI-PROJECT-15K19102
[Journal Article] CASTB (the comprehensive analysis server for the Mycobacterium tuberculosis complex): A publicly accessible web server for epidemiological analyses, drug-resistance prediction and phylogenetic comparison of clinical isolates.2015
- Author(s)
  Iwai H, Kato-Miyazawa M, Kirikae T, Miyoshi-Akiyama T.
- Journal Title
  
  Tuberculosis (Edinb)
  
  Volume: 95(6) Issue: 6 Pages: 843-4
- DOI
  10.1016/j.tube.2015.09.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19102
[Journal Article] Complete annotated genome sequence of Mycobacterium tuberculosis (Zopf) Lehmann and Neumann (ATCC35812) (Kurono).2015
- Author(s)
  Miyoshi-Akiyama T, Satou K, Kato M, Shiroma A, Matsumura K, Tamotsu H, Iwai H, Teruya K, Funatogawa K, Hirano T, Kirikae T.
- Journal Title
  
  Tuberculosis
  
  Volume: 95(1) Issue: 1 Pages: 37-39
- DOI
  10.1016/j.tube.2014.10.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860331
[Journal Article] MicroRNA-155 knockout mice are susceptible to Mycobacterium tuberculosis infection.2015
- Author(s)
  Iwai H, Funatogawa K, Matsumura K, Kato-Miyazawa M, Kirikae F, Kiga K, Sasakawa C, Miyoshi-Akiyama T, Kirikae T.
- Journal Title
  
  Tuberculosis
  
  Volume: 95(3) Issue: 3 Pages: 246-250
- DOI
  10.1016/j.tube.2015.03.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860331
[Presentation] A Mutation in the 16S rRNA Decoding Region Attenuates the Virulence of Mycobacterium tuberculosis2017
- Author(s)
  Shinya Watanabe, Kazunori Matsumura, Hiroki Iwai, Keiji Funatogawa, Yuji Haishima, Chie Fukui, Kayo Okumura, Masako Kato-Miyazawa, Masahito Hashimoto, Kanae Teramoto, Fumiko Kirikae, Tohru Miyoshi-Akiyama, Teruo Kirikae
- Organizer
  Keystone Symposia, New Developments in Our Basic Understanding of Tuberculosis (A5)
- Place of Presentation
  Fairmont Hotel Vancouver, Vancouver, Brithish Columbia, Canada
- Year and Date
  2017-01-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19102
[Presentation] Analysis of PRDX1 which contributes to host defenses against Mycobacterium tuberculosis2017
- Author(s)
  松村和典，祝弘樹，加藤-宮澤雅子，切替富美子，趙吉子，柳川徹，石井哲郎，舩渡川圭次，秋山徹，切替照雄
- Organizer
  第90回日本細菌学会総会
- Place of Presentation
  仙台国際センター展示棟
- Year and Date
  2017-03-19
- Data Source
  KAKENHI-PROJECT-15K19102
[Presentation] カナマイシン耐性に寄与する16SリボゾームRNA の解読領域の変異と結核菌の弱毒化2017
- Author(s)
  渡邊真弥，松村和典，祝弘樹，舩渡川圭次，加藤雅子，切替富美子，秋山徹，崔龍洙，切替照雄
- Organizer
  第90回日本細菌学会総会
- Place of Presentation
  仙台国際センター展示棟
- Year and Date
  2017-03-19
- Data Source
  KAKENHI-PROJECT-15K19102
[Presentation] A mycobacterial virulence protein, PE_P GRS62, inhibits autophagy in macrophage s2016
- Author(s)
  Hiroki Iwai, Kazunori Matsumura, Fumiko Kirikae, Jeffery Cox, Keiji Funatogawa, Toru Miyoshi-Akiyama, Teruo Kirikae
- Organizer
  The 24th International Symposium on Molecular Cell Biology of Macrophages
- Place of Presentation
  Sola City Conference Center
- Year and Date
  2016-06-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19102
[Presentation] Rv3812-encoded PE_PGRS62 protein is surface-exposed in tubercle bacilli2016
- Author(s)
  Hiroki Iwai, Miwa Tamura-Nakano, Kazunori Matsumura, Yuji Miyamoto, Tetsu Mukai, Masahiko Makino, Cox Jeffery, Keiji Funatogawa, Toru Miyoshi-Akiyama, Teruo Kirikae
- Organizer
  第８９回日本細菌学会総会
- Place of Presentation
  大阪国際交流センター
- Year and Date
  2016-03-23
- Data Source
  KAKENHI-PROJECT-15K19102
[Presentation] Peroxiredoxin 1 contributes to host defense against Mycobacterium tuberculosis2014
- Author(s)
  松村和典, 祝弘樹, 加藤雅子, 切替富美子, 舩渡川圭次, 秋山徹, 切替照雄
- Organizer
  第８７回日本細菌学会総会
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-25860331
[Presentation] Mycobacterial PE_PGRS62 gene is a virulence factor during tuberculosis2013
- Author(s)
  Hiroki Iwai, Teruo Kirikae
- Organizer
  The 12th Awaji Intetrnational Forum on Infection and Immunity
- Place of Presentation
  淡路夢舞台国際会議場
- Data Source
  KAKENHI-PROJECT-25860331
[Presentation] 結核菌タンパク質のユビキチン化と宿主細胞のホメオスタシス2013
- Author(s)
  祝弘樹
- Organizer
  第 7 回細菌学若手コロッセウム
- Place of Presentation
  広島エアポートホテル
- Data Source
  KAKENHI-PROJECT-25860331
[Presentation] 肺胞II型上皮細胞の恒常性機能を利用した結核菌の感染戦略
- Author(s)
  祝　弘樹
- Organizer
  第８回細菌学若手コロッセウム
- Place of Presentation
  ホテルニセコいこいの村
- Year and Date
  2014-08-06 – 2014-08-08
- Data Source
  KAKENHI-PROJECT-25860331
[Presentation] Micro-RNA 155 mediates CD4+ T cell responses to Mycobacterium tuberculosis
- Author(s)
  祝弘樹、舩渡川圭次、松村和典、加藤雅子、切替富美子、氣駕恒太朗、笹川千尋、秋山徹、切替照雄
- Organizer
  第８８回日本細菌学会総会
- Place of Presentation
  長良川国際会議場
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25860331
[Presentation] 16S リボゾーム RNA の解読領域の変異は結核菌を弱毒化する
- Author(s)
  舩渡川圭次, 渡邊真弥, 祝弘樹, はい島由二, 奥村香世, 加藤雅子, 橋本雅仁, 切替富美子, 秋山徹, 切替照雄
- Organizer
  第８７回日本細菌学会総会
- Place of Presentation
  タワーホール船堀
- Invited
- Data Source
  KAKENHI-PROJECT-25860331

1. WATANABE Shinya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIROKI Iwai 祝 弘樹

Research Projects

Research Products

Co-Researchers

創薬にむけた結核菌膜タンパク質の親水性膜外領域に結合するペプチドの探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Biogenesis of lamellar body-like organelles in host cells expressing Mycobacterium tuberculosis PE_PGRS62Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of PE_PGRS62 in autophagosome formation by Mycobacterium tuberculosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Peroxiredoxin 1 Contributes to Host Defenses against Mycobacterium tuberculosis.2016

Author(s)

Journal Title

Data Source

[Journal Article] A mutation in the decoding region of 16S rRNA attenuates the virulence of Mycobacterium tuberculosis.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CASTB (the comprehensive analysis server for the Mycobacterium tuberculosis complex): A publicly accessible web server for epidemiological analyses, drug-resistance prediction and phylogenetic comparison of clinical isolates.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Complete annotated genome sequence of Mycobacterium tuberculosis (Zopf) Lehmann and Neumann (ATCC35812) (Kurono).2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MicroRNA-155 knockout mice are susceptible to Mycobacterium tuberculosis infection.2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] A Mutation in the 16S rRNA Decoding Region Attenuates the Virulence of Mycobacterium tuberculosis2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Analysis of PRDX1 which contributes to host defenses against Mycobacterium tuberculosis2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] カナマイシン耐性に寄与する16SリボゾームRNA の解読領域の 変異と結核菌の弱毒化2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] A mycobacterial virulence protein, PE_P GRS62, inhibits autophagy in macrophage s2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Rv3812-encoded PE_PGRS62 protein is surface-exposed in tubercle bacilli2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Peroxiredoxin 1 contributes to host defense against Mycobacterium tuberculosis2014

Author(s)

Organizer

Place of Presentation

HIROKI Iwai 祝弘樹

[Presentation] カナマイシン耐性に寄与する16SリボゾームRNA の解読領域の変異と結核菌の弱毒化2017