Hiro Junichiro 廣純一郎

… Alternative Names

HIRO JYUNICHIRO 廣純一郎

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Researcher Number	70444437
Other IDs
Affiliation (Current)	2025: 藤田医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2021: 三重大学, 医学系研究科, リサーチアソシエイト 2016 – 2019: 三重大学, 医学系研究科, 助教 2016: 三重大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Digestive surgery Except Principal Investigator Digestive surgery
Keywords	Principal Investigator バイオマーカー / 大腸癌 / エピゲノム / Budding / microRNAパネル / tumor budding grade / microRNA / Tumor Budding grade / 免疫療法 / 腫瘍浸潤Ｔリンパ球 … More / マイクロサテライト不安定性 / 遺伝子解析 / PD-L1 / PD-１ … More Except Principal Investigator バイオマーカー / microRNA / 癌化 / 潰瘍性大腸炎 / マイクロRNA / DNAメチル化 Less

Development of novel epigenetic biomarker for identification of tumor buddding in CRCPrincipal Investigator
- Principal Investigator
  
  Hiro Junichiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Mie University
Clinical burden of PD-L1-PD-1 axis in colorectal cancerPrincipal Investigator
- Principal Investigator
  
  Hiro Junichiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Mie University
DNA methylation biomarkers predict development of UC-associated colorectal neoplasia
- Principal Investigator
  
  Toiyama Yuji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Mie University

All 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation

[Journal Article] Soluble PD-L1 Expression in Circulation as a Predictive Marker for Recurrence and Prognosis in Gastric Cancer: Direct Comparison of the Clinical Burden Between Tissue and Serum PD-L1 Expression.2019
- Author(s)
  Shigemori T, Toiyama Y, Okugawa Y, Yamamoto A, Yin C, Narumi A, Ichikawa T, Ide S, Shimura T, Fujikawa H, Yasuda H, Hiro J, Yoshiyama S, Ohi M, Araki T, Kusunoki M.
- Journal Title
  
  Ann Surg Oncol.
  
  Volume: 26 Issue: 3 Pages: 876-883
- DOI
  10.1245/s10434-018-07112-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10583, KAKENHI-PROJECT-18K08592, KAKENHI-PROJECT-18K08675, KAKENHI-PROJECT-16K10497, KAKENHI-PROJECT-16K10533, KAKENHI-PROJECT-18K08674, KAKENHI-PROJECT-18K08700
[Journal Article] Prognostic impact of sarcopenia and its correlation with circulating miR-21 in colorectal cancer patients.2018
- Author(s)
  Okugawa Y, Yao L, Toiyama Y, Yamamoto A, Shigemori T, Yin C, Omura Y, Ide S, Kitajima T, Shimura T, Fujikawa H, Yasuda H, Hiro J, Yoshiyama S, Kobayashi M, Tanaka K, Inoue Y, Araki T, Miki C, Kusunoki M.
- Journal Title
  
  Oncol Rep.
  
  Volume: 39 Pages: 1555-1564
- DOI
  10.3892/or.2018.6270
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10533, KAKENHI-PROJECT-15K10134, KAKENHI-PROJECT-26293301
[Journal Article] Clinical Impact of Muscle Quantity and Quality in Colorectal Cancer Patients: A Propensity Score Matching Analysis.2018
- Author(s)
  Okugawa Y, Toiyama Y, Yamamoto A, Shigemori T, Yin C, Narumi A, Omura Y, Ide S, Kitajima T, Fujikawa H, Yasuda H, Hiro J, Yoshiyama S, Kobayashi M, Araki T, McMillan DC, Miki C, Kusunoki M.
- Journal Title
  
  JPEN J Parenter Enteral Nutr.
  
  Volume: 42(8) Issue: 8 Pages: 1322-1333
- DOI
  10.1002/jpen.1171
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10533
[Journal Article] Enhanced AZIN1 RNA editing and overexpression of its regulatory enzyme ADAR1 are important prognostic biomarkers in gastric cancer2018
- Author(s)
  Okugawa Yoshinaga、Toiyama Yuji、Shigeyasu Kunitoshi、Yamamoto Akira、Shigemori Tsunehiko、Yin Chengzeng、Ichikawa Takashi、Yasuda Hiromi、Fujikawa Hiroyuki、Yoshiyama Shigeyuki、Hiro Junichiro、Ohi Masaki、Araki Toshimitsu、Kusunoki Masato、Goel Ajay
- Journal Title
  
  Journal of Translational Medicine
  
  Volume: 16 Issue: 1 Pages: 366-366
- DOI
  10.1186/s12967-018-1740-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10584, KAKENHI-PROJECT-18K08592, KAKENHI-PROJECT-18K08674, KAKENHI-PROJECT-16K10497, KAKENHI-PROJECT-16K10533
[Journal Article] Feasibility of Assessing Prognostic Nutrition Index in Patients With Rectal Cancer Who Receive Preoperative Chemoradiotherapy2018
- Author(s)
  Okugawa Y, Toiyama Y, Oki S, Ide S, Yamamoto A, Ichikawa T, Kitajima T, Fujikawa H, Yasuda H, Saigusa S, Hiro J, Yoshiyama S, Kobayashi M, Araki T, Kusunoki M
- Journal Title
  
  JPEN J Parenter Enteral Nutr.
  
  Volume: 42(6) Issue: 6 Pages: 998-1007
- DOI
  10.1002/jpen.1041
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10533
[Journal Article] Proteomics analysis of differential protein expression identifies heat shock protein 47 as a predictive marker for lymph node metastasis in patients with colorectal cancer.2017
- Author(s)
  Mori K, Toiyama Y, Otake K, Fujikawa H, Saigusa S, Hiro J, Kobayashi M, Ohi M, Tanaka K, Inoue Y, Kobayashi Y, Kobayashi I, Mohri Y, Goel A, Kusunoki M.
- Journal Title
  
  Int J Cancer.
  
  Volume: 140 Issue: 6 Pages: 1425-1435
- DOI
  10.1002/ijc.30557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10533, KAKENHI-PROJECT-15K10134
[Journal Article] Successful identification of a predictive biomarker for lymph node metastasis in colorectal cancer using a proteomic approach.2017
- Author(s)
  Mori K, Toiyama Y, Otake K, Ide S, Imaoka H, Okigami M, Okugawa Y, Fujikawa H, Saigusa S, Hiro J, Kobayashi M, Ohi M, Tanaka K, Inoue Y, Kobayashi Y, Mohri Y, Kobayashi I, Goel A, Kusunoki M.
- Journal Title
  
  Oncotarget.
  
  Volume: 8 Issue: 63 Pages: 106935-106947
- DOI
  10.18632/oncotarget.22149
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10533, KAKENHI-PROJECT-26293301, KAKENHI-PROJECT-15K10134
[Journal Article] Elevated serum concentration of monocyte chemotactic protein 4 (MCP-4) as a novel non-invasive prognostic and predictive biomarker for detection of metastasis in colorectal cancer.2016
- Author(s)
  Okugawa Y, Toiyama Y, Mohri Y, Tanaka K, Kawamura M, Hiro J, Araki T, Inoue Y, Miki C, Kusunoki M
- Journal Title
  
  J Surg Oncol.
  
  Volume: 114 Issue: 4 Pages: 483-489
- DOI
  10.1002/jso.24335
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10533
[Journal Article] Diagnostic Potential of Cell-Free and Exosomal MicroRNAs in the Identification of Patients with High-Risk Colorectal Adenomas.2016
- Author(s)
  Uratani R, Toiyama Y, Kitajima T, Kawamura M, Hiro J, Kobayashi M, Tanaka K, Inoue Y, Mohri Y, Mori T, Kato T, Goel A, Kusunoki M.
- Journal Title
  
  PLoS One.
  
  Volume: 11(10) Issue: 10 Pages: e0160722-e0160722
- DOI
  10.1371/journal.pone.0160722
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293301, KAKENHI-PROJECT-16K10533, KAKENHI-PROJECT-16K15612
[Journal Article] Circulating microRNA-1290 as a novel diagnostic and prognostic biomarker in human colorectal cancer2016
- Author(s)
  Imaoka H, Toiyama Y, Fujikawa H, Hiro J, Saigusa S, Tanaka K, Inoue Y, Mohri Y, Mori T, Kato T, Toden S, Goel A, Kusunoki M.
- Journal Title
  
  Ann Oncol.
  
  Volume: 27(10） Issue: 10 Pages: 1879-1886
- DOI
  10.1093/annonc/mdw279
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293301, KAKENHI-PROJECT-16K10533, KAKENHI-PROJECT-16K15612
[Journal Article] miRNA-503 Promotes Tumor Progression and Is Associated with Early Recurrence and Poor Prognosis in Human Colorectal Cancer.2016
- Author(s)
  Noguchi T, Toiyama Y, Kitajima T, Imaoka H, Hiro J, Saigusa S, Tanaka K, Inoue Y, Mohri Y, Toden S, Kusunoki M
- Journal Title
  
  Oncology.
  
  Volume: 90(4) Issue: 4 Pages: 221-231
- DOI
  10.1159/000444493
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293301, KAKENHI-PROJECT-16K10533
[Presentation] The association between tumor tissue miR-34a expression, tumor budding grade, and the clinical significance in surgically resected colorectal cancer patients2020
- Author(s)
  Tadanobu Shimura, Yoshinaga Okugawa, Takahito Kitajima, Akira Yamamoto, Shozo Ide, Hiroyuki Fujikawa, Yoshiki Okita, Takeshi Yokoe, Masaki Ohi, Ajay Goel, and Yuji Toiyama
- Organizer
  The 30th Biennial Congress of ISUCRS2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09216
[Presentation] 大腸癌組織におけるmiRNA-375の発現とhigh grade簇出との関連、ならびにその臨床的意義2019
- Author(s)
  志村匡信、問山裕二、奥川喜永、北嶋貴仁、井出正造、安田裕美、藤川裕之、廣純一郎、大井正貴、荒木俊光、今井裕、渡邉昌俊、Ajay Goel、楠正人
- Organizer
  第74回日本大腸肛門病学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09216
[Presentation] 大腸癌肝転移患者におけるHypoxia Inducible Factor 3A(HIF3)遺伝子内のLoss of heterozygosity(LOH)についての検討2017
- Author(s)
  北嶋貴仁、問山裕二、奥川喜永、井出正造、近藤　哲、今岡裕基、廣純一郎、小林美奈子、楠正人
- Organizer
  第76回日本癌学会学術総会、横浜、2017.9.29
- Data Source
  KAKENHI-PROJECT-16K10533
[Presentation] 潰瘍性大腸炎患者の大腸粘膜におけるmiR-137メチル化の臨床病理学的意義2016
- Author(s)
  問山裕二, 奥川喜永, 今岡裕貴, 沖上正人, 藤川裕之, 三枝晋, 廣純一郎, 小林美奈子, 大井正貴, 荒木俊光, 井上靖浩, 毛利靖彦, 楠正人.
- Organizer
  日本大腸肛門病学会学会
- Place of Presentation
  三重県営サンアリーナ（三重県伊勢市）
- Year and Date
  2016-11-18
- Data Source
  KAKENHI-PROJECT-26462011
[Presentation] 潰瘍性大腸炎粘膜におけるLINE-1ならびにESR1メチル化レベルの臨床的意義.2016
- Author(s)
  問山裕二, 廣純一郎, 小林美奈子, 荒木俊光, 大北喜基, 井上靖浩, 毛利靖彦, 楠正人
- Organizer
  日本癌治療学会学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-20
- Data Source
  KAKENHI-PROJECT-26462011
[Presentation] 直腸癌に対する腹腔鏡下括約筋間切除・Coloplasty肛門吻合の手術手技と成績2016
- Author(s)
  廣純一郎, 井上靖浩, 藤川裕之, 沖上正人, 今岡裕基, 問山裕二, 小林美奈子, 荒木俊光, 毛利靖彦, 楠正人
- Organizer
  第78回日本臨床外科学会
- Place of Presentation
  品川プリンスホテル(東京都、品川区)
- Year and Date
  2016-11-24
- Data Source
  KAKENHI-PROJECT-16K10533
[Presentation] 膿瘍や瘻孔形成を伴った大腸憩室炎に対する腹腔鏡下手術の適応と成績2016
- Author(s)
  廣純一郎, 藤川裕之, 問山裕二, 井上靖浩, 沖上正人, 今岡裕基, 小林美奈子, 荒木俊光, 毛利靖彦, 楠正人
- Organizer
  第72回日本大腸肛門病学会
- Place of Presentation
  伊勢サンアリーナ(三重県、伊勢市）
- Year and Date
  2016-11-18
- Data Source
  KAKENHI-PROJECT-16K10533
[Presentation] 右側結腸癌に対する腹腔鏡下手術のリンパ節郭清と出血に対するポイントと対策2016
- Author(s)
  廣純一郎, 井上靖浩, 藤川裕之, 今岡祐基, 沖上正人, 問山裕二, 奥川喜永, 毛利靖彦, 楠正人
- Organizer
  第71回日本消化器外科学会
- Place of Presentation
  アスティ徳島(徳島県、徳島市）
- Year and Date
  2016-07-14
- Data Source
  KAKENHI-PROJECT-16K10533
[Presentation] 散発性ならびに潰瘍性大腸炎関連癌におけるエピゲノム異常から見た発癌、予後に対するリスク診断法2015
- Author(s)
  Yuji Toiyama, Yoshinaga Okugawa, Junichiro Hiro, Minako Kobayashi, Masaki Ohi, Toshimitsu Araki, Koji Tanaka, Yasuhiro Inoue, Yasuhiko Mohri, Masato Kusunoki
- Organizer
  日本消化器外科学会総会
- Place of Presentation
  アクトシティ浜松（静岡県・浜松市）
- Year and Date
  2015-07-15
- Data Source
  KAKENHI-PROJECT-26462011
[Presentation] Methylation Status in a Panel of MicroRNAs Predicts the Development of UCAssociated Colorectal Neoplasia
- Author(s)
  Yoshinaga Okugawa, Yuji Toiyama, Keun Hur, Koji Tanaka, Yasuhiro Inoue, Masato Kusunoki, C. Richard Boland, Ajay Goel
- Organizer
  DDW　2014
- Place of Presentation
  アメリカ合衆国　（シカゴ）
- Year and Date
  2014-05-04 – 2014-05-06
- Data Source
  KAKENHI-PROJECT-26462011
[Presentation] MicroRNA-124プロモーター領域メチル化の大腸癌バイオマーカーとしての可能性
- Author(s)
  問山裕二, Hur Keun, 川村幹雄, 川本文, 奥川喜永, 廣純一郎, 田中光司, 井上靖浩, 永坂岳志, 毛利靖彦, 楠正人, Boland Richard C., Goel Ajay
- Organizer
  日本外科学会
- Place of Presentation
  京都　（国立京都国際会館・グランドプリンスホテル京都）
- Year and Date
  2014-04-03 – 2014-04-05
- Data Source
  KAKENHI-PROJECT-26462011
[Presentation] 潰瘍性大腸炎癌化におけるmicroRNA-124、-137、-34b/cメチル化の意義
- Author(s)
  問山裕二, Hur Keun, 沖上正人, 川村幹雄, 川本文, 奥川喜永, 廣純一郎, 荒木俊光, 田中光司, 井上靖浩, 内田恵一, 毛利靖彦, 楠正人, Boland Richard C., Goel Ajay
- Organizer
  日本癌治療学会
- Place of Presentation
  横浜　（パシフィコ横浜）
- Year and Date
  2014-08-28 – 2014-08-30
- Data Source
  KAKENHI-PROJECT-26462011

1. Toiyama Yuji (00422824)

# of Collaborated Projects: 3 results

# of Collaborated Products: 23 results
2. 楠正人 (50192026)

# of Collaborated Projects: 3 results

# of Collaborated Products: 22 results
3. FUJIKAWA HIROYUKI (40616091)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. 井上靖浩 (20324535)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
5. KONDO SATORU (60763737)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 川村幹雄 (00722589)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 荒木俊光 (70343217)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. YOSHIYAMA Shigeyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. MOHRI Yasuhiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
10. 安田裕美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 大井正貴

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hiro Junichiro 廣 純一郎

HIRO JYUNICHIRO 廣 純一郎

Research Projects

Research Products

Co-Researchers

Development of novel epigenetic biomarker for identification of tumor buddding in CRCPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clinical burden of PD-L1-PD-1 axis in colorectal cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DNA methylation biomarkers predict development of UC-associated colorectal neoplasia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Soluble PD-L1 Expression in Circulation as a Predictive Marker for Recurrence and Prognosis in Gastric Cancer: Direct Comparison of the Clinical Burden Between Tissue and Serum PD-L1 Expression.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prognostic impact of sarcopenia and its correlation with circulating miR-21 in colorectal cancer patients.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical Impact of Muscle Quantity and Quality in Colorectal Cancer Patients: A Propensity Score Matching Analysis.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enhanced AZIN1 RNA editing and overexpression of its regulatory enzyme ADAR1 are important prognostic biomarkers in gastric cancer2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Feasibility of Assessing Prognostic Nutrition Index in Patients With Rectal Cancer Who Receive Preoperative Chemoradiotherapy2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Proteomics analysis of differential protein expression identifies heat shock protein 47 as a predictive marker for lymph node metastasis in patients with colorectal cancer.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Successful identification of a predictive biomarker for lymph node metastasis in colorectal cancer using a proteomic approach.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Elevated serum concentration of monocyte chemotactic protein 4 (MCP-4) as a novel non-invasive prognostic and predictive biomarker for detection of metastasis in colorectal cancer.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Diagnostic Potential of Cell-Free and Exosomal MicroRNAs in the Identification of Patients with High-Risk Colorectal Adenomas.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Circulating microRNA-1290 as a novel diagnostic and prognostic biomarker in human colorectal cancer2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] miRNA-503 Promotes Tumor Progression and Is Associated with Early Recurrence and Poor Prognosis in Human Colorectal Cancer.2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] The association between tumor tissue miR-34a expression, tumor budding grade, and the clinical significance in surgically resected colorectal cancer patients2020

Author(s)

Hiro Junichiro 廣純一郎

HIRO JYUNICHIRO 廣純一郎