KIKUGAWA Tadahiko 菊川忠彦

… Alternative Names

Kikugawa Tadahiko 菊川忠彦

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Researcher Number	70444734
Other IDs	https://orcid.org/0000-0002-8992-4167
Affiliation (Current)	2025: 愛媛大学, 医学部附属病院, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 愛媛大学, 医学部附属病院, 准教授 2017 – 2020: 愛媛大学, 医学系研究科, 准教授
Review Section/Research Field	Principal Investigator Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 56030:Urology-related / Urology Except Principal Investigator Basic Section 56030:Urology-related / Basic Section 90130:Medical systems-related
Keywords	Principal Investigator 質量分析法 / 導管癌 / 神経内分泌癌 / シングルセル解析 / 前立腺癌 / 腎癌 / PSMA / 腎がん / 腫瘍学 / AlphaScreen法 / SPOP / ユビキチンリガーゼ / 前立腺がん … More Except Principal Investigator … More 前立腺癌 / 水腎症 / 腎盂内圧測定 / 骨転移 / PSMA / FAT4 / 新規治療標的 / CDH11 / 転移性膀胱癌 / 数値流体計算 / スフェロイド / 導管内浸潤前立腺癌 / 制御因子 / 遺伝子解析 / 神経内分泌分化 / IDCP / シングルセル解析 / 空間的遺伝子発現解析 / 神経内分泌前立腺癌 / ガイド波 / 腎盂内圧 / 反射波 / 生体膜 / 血管内皮細胞 / アンドロゲン受容体 / サルコペニア / アンドロゲン / C2C12 / Akt / 骨格筋 / 上皮成長因子受容体 / androgen receptor / androgen / データベース / 分子機構 / 転移制御 / 前立腺がん / Cullin3型ユビキチンリガーゼ / CUL3 / prostate cancer specimen / tube formation / LNCaP / HUVECs / tumor endothelial cells Less

前立腺癌骨転移の分子メカニズム解明と革新的治療法開発への基盤的研究
- Principal Investigator
  
  雑賀隆史
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Ehime University
前立腺癌スフェロイドのシングルセル解析による導管内浸潤前立腺癌の病態解明
- Principal Investigator
  
  三浦徳宣
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Ehime University
数値流体計算を用いた腎盂内圧力変化の解析と腎盂内圧が腎機能へ与える影響
- Principal Investigator
  
  西村謙一
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90130:Medical systems-related
- Research Institution
  Ehime University
ビッグデータ解析を用いた転移性膀胱癌に対する新規治療標的分子の探索
- Principal Investigator
  
  新井欧介
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Ehime University
腎癌関連血管内皮細胞におけるPSMAの発現制御機構及び、その分子機能の解明Principal Investigator
- Principal Investigator
  
  菊川忠彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Ehime University
International collaboration research on the identification of novel driver genes for prostate cancer by single cell analysis.Principal Investigator
- Principal Investigator
  
  菊川忠彦
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Ehime University
シングルセル解析による腫瘍微小環境を介した前立腺神経内分泌腫瘍発生機序の解明
- Principal Investigator
  
  渡辺隆太
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Ehime University
fundamental study for indirect regulattions of skeletal muscle mass by androgen-like action outside of skeletal muscle fibers
- Principal Investigator
  
  Saika Takashi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Ehime University
Regulatory mechanisms of PSMA expression and its molecular functions in prostate cancer-associated vascular endothelial cells.
- Principal Investigator
  
  Miura Noriyoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Ehime University
Development of a new non-invasive intra-renal pelvis pressure measurement based on non-destructive engineering techniques.
- Principal Investigator
  
  Nishimura Kenichi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90130:Medical systems-related
- Research Institution
  Ehime University
Analysis of the molecular mechanism of PSMA in prostate cancer cells
- Principal Investigator
  
  Miura Noriyoshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Ehime University
exploring innovative therapeutic target for bone metastatic prostate cancer based on analysis of molecular mechanism.
- Principal Investigator
  
  SAIKA TAKASHI
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Ehime University
The identification of CUL3-SPOP and CUL3-PLZF target substrates for therapeutic targets in prostate cancer cellsPrincipal Investigator
- Principal Investigator
  
  Kikugawa Tadahiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Ehime University

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation Patent

[Journal Article] Spatial Gene Expression Analysis Reveals Characteristic Gene Expression Patterns of De Novo Neuroendocrine Prostate Cancer Coexisting with Androgen Receptor Pathway Prostate Cancer2023
- Author(s)
  Watanabe Ryuta、Miura Noriyoshi、Kurata Mie、Kitazawa Riko、Kikugawa Tadahiko、Saika Takashi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 10 Pages: 8955-8955
- DOI
  10.3390/ijms24108955
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09449, KAKENHI-PROJECT-21K09373
[Journal Article] Senescent <scp>CD8</scp> <sup>+</sup> T cells acquire <scp>NK</scp> cell‐like innate functions to promote antitumor immunity2023
- Author(s)
  Kakuda Toshio、Suzuki Junpei、Matsuoka Yuko、Kikugawa Tadahiko、Saika Takashi、Yamashita Masakatsu
- Journal Title
  
  Cancer Science
  
  Volume: x Issue: 7 Pages: 2810-2820
- DOI
  10.1111/cas.15824
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03504, KAKENHI-PROJECT-21K09373
[Journal Article] IDCP症例における遺伝子異常の解析2023
- Author(s)
  渡辺隆太、塩出涼、鈴木大一郎、信森祥太、杉原直哉、山川真季、佐伯佳央里、河野玲奈、新井欧介、大西智也、角田俊雄、野田輝乙、西村謙一、福本哲也、三浦徳宣、倉田美恵、宮内勇貴、北澤理子、Michael C Haffner、菊川忠彦、雑賀隆史
- Journal Title
  
  泌尿器外科
  
  Volume: 36(8) Pages: 939-941
- Data Source
  KAKENHI-PROJECT-22K09449
[Journal Article] Uhrf1 governs the proliferation and differentiation of muscle satellite cells.2022
- Author(s)
  Sakai H, Sawada Y, Tokunaga N, Tanaka K, Nakagawa S, Sakakibara I, Ono Y, Fukada SI, Ohkawa Y, Kikugawa T, Saika T, Imai Y.
- Journal Title
  
  iScience.
  
  Volume: 25 Issue: 3 Pages: 103928-103928
- DOI
  10.1016/j.isci.2022.103928
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21398, KAKENHI-PUBLICLY-20H04846, KAKENHI-PUBLICLY-21H00232, KAKENHI-PROJECT-20H00456, KAKENHI-PROJECT-19H03786, KAKENHI-PROJECT-21K09373, KAKENHI-PROJECT-21K17568, KAKENHI-PROJECT-23K24462
[Journal Article] CD21lo B Cells Could Be a Potential Predictor of Immune-Related Adverse Events in Renal Cell Carcinoma.2022
- Author(s)
  Nishimura K, Konishi T, Ochi T, Watanabe R, Noda T, Fukumoto T, Miura N, Miyauchi Y, Kikugawa T, Takenaka K, Saika T.
- Journal Title
  
  J Pers Med.
  
  Volume: 12 Issue: 6 Pages: 888-894
- DOI
  10.3390/jpm12060888
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09373, KAKENHI-PROJECT-21H02949
[Journal Article] PSMA‐positive membranes secreted from prostate cancer cells have potency to transform vascular endothelial cells into an angiogenic state2021
- Author(s)
  Watanabe Ryuta、Maekawa Masashi、Kiyoi Takeshi、Kurata Mie、Miura Noriyoshi、Kikugawa Tadahiko、Higashiyama Shigeki、Saika Takashi
- Journal Title
  
  The Prostate
  
  Volume: 81 Issue: 16 Pages: 1390-1401
- DOI
  10.1002/pros.24237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K09427
[Journal Article] GPRC5A facilitates cell proliferation through cell cycle regulation and correlates with bone metastasis in prostate cancer2020
- Author(s)
  Sawada Y, Kikugawa T, Iio H, Sakakibara I, Yoshida S, Ikedo A, Yanagihara Y, Saeki N, Gyorffy B, Kishida T, Okubo Y, Nakamura Y, Miyagi Y, Saika T, Imai Y.
- Journal Title
  
  International Journal of Cancer
  
  Volume: 146 Issue: 5 Pages: 1369-1382
- DOI
  10.1002/ijc.32554
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09168, KAKENHI-PROJECT-19K16015, KAKENHI-PROJECT-19H03786, KAKENHI-PROJECT-16H06277
[Journal Article] SPOP is essential for DNA-protein crosslink repair in prostate cancer cells: SPOP-dependent removal of topoisomerase 2A from the topoisomerase 2A-DNA cleavage complex.2020
- Author(s)
  Watanabe R, Maekawa M, Hieda M, Taguchi T, Miura N, Kikugawa T, Saika T, Higashiyama S.
- Journal Title
  
  Mol Biol Cell
  
  Volume: 31 Issue: 6 Pages: 478-490
- DOI
  10.1091/mbc.e19-08-0456
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06226, KAKENHI-PROJECT-19K18613, KAKENHI-PROJECT-18K09137
[Journal Article] SPOP is essential for DNA-protein cross-link repair in prostate cancer cells: SPOP-dependent removal of topoisomerase 2A from the topoisomerase 2A-DNA cleavage complex.2020
- Author(s)
  Watanabe R, Kikugawa T, Saika T, Higashiyama S, et al.
- Journal Title
  
  Molecular Biology of the Cell
  
  Volume: 31 Issue: 8 Pages: 478-490
- DOI
  10.1091/mbc.
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11142
[Patent] 前立腺癌の骨転移判定方法2018
- Inventor(s)
  今井祐記、雑賀隆史、菊川忠彦、沢田雄一郎
- Industrial Property Rights Holder
  株式会社プラスパブレインズ、今井祐記
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-198404
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-18K09168
[Presentation] A genetic landscape of de novo neuroendocrine prostate cancer and possible novel therapeutic strategies unveiled by spatial gene expression analysis2024
- Author(s)
  Ryuta Watanabe, Noriyoshi Miura, Tadahiko Kikugawa, Takashi Saika
- Organizer
  2024 AUA Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0135
[Presentation] データ解析を応用した転移性尿路上皮癌治療標的分子の探索2024
- Author(s)
  新井欧介,柳原裕太, 渡辺隆太, 三浦徳宣, 今井祐記, 菊川忠彦, 雑賀隆史
- Organizer
  第33回泌尿器分子細胞研究会
- Data Source
  KAKENHI-PROJECT-23K08759
[Presentation] Exploring the Genomic Landscape of de novo Neuroendocrine Prostate Cancer: Insights for Innovative Therapies from Spatial Gene Expression Analysis2024
- Author(s)
  Ryuta Watanabe, Noriyoshi Miura, Tadahiko Kikugawa, Takashi Saika
- Organizer
  the 39th Annual EAU Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0135
[Presentation] Exploring the Genomic Landscape of de novo Neuroendocrine Prostate Cancer: Insights for Innovative Therapies from Spatial Gene Expression Analysis2024
- Author(s)
  Ryuta Watanabe, Noriyoshi Miura, Tadahiko Kikugawa, Takashi Saika
- Organizer
  AACR Annual Meeting 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0135
[Presentation] Prostate-specific membrane antigen expression in endothelial cells of renal tumor-associated neovasculature and risk of recurrence for renal cell carcinoma2024
- Author(s)
  Tadahiko Kikugawa, Keito Kagimoto, Ryuta Watanabe, Noriyoshi Miura, Takashi Saika
- Organizer
  第111回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-22K09529
[Presentation] Prostate-specific membrane antigen expression in endothelial cells of renal tumor-associated neovasculature and risk of recurrence for renal cell carcinoma2024
- Author(s)
  Tadahiko Kikugawa
- Organizer
  JUA
- Data Source
  KAKENHI-PROJECT-21K09427
[Presentation] Prostate-specific membrane antigen expression in endothelial cells of renal tumor-associated neovasculature and risk of recurrence for renal cell carcinoma2024
- Author(s)
  Tadahiko Kikugawa, Keito Kagimoto, Ryuta Watanabe, Noriyoshi Miura, Takashi Saika
- Organizer
  2024 ASCO GENITOURINARY CANCERS SYMPOSIUM
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09529
[Presentation] Prostate-Specific Membrane Antigen Expression in Endothelial Cells of Renal Tumor-Associated Neovasculature and Risk of Recurrence for Renal Cell Carcinoma2023
- Author(s)
  Tadahiko Kikugawa, Keito Kagimoto, Ryuta Watanabe, Noriyoshi Miura, Takashi Saika
- Organizer
  The 43rd Congress of the Societe Internationale d`Urologie
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09529
[Presentation] A novel function of a prostate cancer-associated SPOP mutant in topoisomerase 2A-dependent DNA-protein crosslink repair2020
- Author(s)
  Masashi Maekawaa, Ryuta Watanabeb, Miki Hieda, Tomohiko Taguchi, Noriyoshi Miura, Tadahiko Kikugawa, Takashi Saika and Shigeki Higashiyama
- Organizer
  第79回　日本癌学会　学術総会
- Data Source
  KAKENHI-PROJECT-18K09137
[Presentation] GPRC5A facilitates cell proliferation and bone metastasis of prostate cancer2019
- Author(s)
  沢田雄一郎　菊川忠彦飯尾浩之　榊原伊織　吉田周平　池戸葵　柳原裕太　佐伯法学　Balazs Gyorffy　岸田健　大久保陽一郎　中村圭靖　宮城洋平雑賀隆史　今井祐記
- Organizer
  第71回西日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-18K09168
[Presentation] 前立腺癌細胞株LNCaP cellsから放出されるPSMA陽性microvesicleが及ぼす血管内皮細胞の質的変化2019
- Author(s)
  渡辺隆太、前川大志、三浦徳宣、菊川忠彦、雑賀隆史、東山繁樹
- Organizer
  第28回泌尿器科分子・細胞研究会
- Data Source
  KAKENHI-PROJECT-18K09137
[Presentation] LNCaP cellから放出されるPSMA陽性microvesicleが及ぼす血管内皮細胞の質的変化2019
- Author(s)
  渡辺隆太　前川大志　三浦徳宣　菊川忠彦　東山繁樹　雑賀隆史
- Organizer
  第28回　泌尿器科分子細胞研究会
- Data Source
  KAKENHI-PROJECT-18K09137
[Presentation] GPRC5A facilitates cell proliferation and bone metastasis of prostate cancer2019
- Author(s)
  沢田雄一郎　菊川忠彦飯尾浩之　榊原伊織　吉田周平　池戸葵　柳原裕太　佐伯法学　Balazs Gyorffy　岸田健　大久保陽一郎　中村圭靖　宮城洋平
- Organizer
  The 34th Annual European Association of Urology Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09168
[Presentation] GPRC5Aは前立腺癌の細胞増殖および骨転移を制御する2019
- Author(s)
  沢田雄一郎　菊川忠彦飯尾浩之　榊原伊織　吉田周平　池戸葵　柳原裕太　佐伯法学　Balazs Gyorffy　岸田健　大久保陽一郎　中村圭靖　宮城洋平
- Organizer
  第28回泌尿器科分子・細胞研究会
- Data Source
  KAKENHI-PROJECT-18K09168
[Presentation] GPRC5A facilitates cell proliferation and bone metastasis of prostate cancer2019
- Author(s)
  沢田雄一郎　菊川忠彦飯尾浩之　榊原伊織　吉田周平　池戸葵　柳原裕太　佐伯法学　Balaz Gyorffy　岸田健　大久保陽一郎　中村圭靖　宮城洋平雑賀隆史　今井祐記
- Organizer
  第37回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-18K09168
[Presentation] 前立腺癌細胞株LNCaP cellsから放出されるPSMA陽性microvesicleが及ぼす血管内皮細胞の質的変化2019
- Author(s)
  渡辺隆太、前川大志、三浦徳宣、菊川忠彦、雑賀隆史、東山繁樹
- Organizer
  第60回日本生化学会中国四国支部例会
- Data Source
  KAKENHI-PROJECT-18K09137
[Presentation] 前立腺がん骨転移制御分子の解析2018
- Author(s)
  沢田雄一郎　菊川忠彦飯尾浩之　榊原伊織　吉田周平　池戸葵　柳原裕太　佐伯法学　Balazs Gyorffy　岸田健　大久保陽一郎　中村圭靖　宮城洋平
- Organizer
  第９回Orthopedic Research Club
- Data Source
  KAKENHI-PROJECT-18K09168
[Presentation] 前立腺癌骨転移の新規治療標的分子PCBM1の同定2018
- Author(s)
  沢田雄一郎　菊川忠彦飯尾浩之　榊原伊織　吉田周平　池戸葵　柳原裕太　佐伯法学　Balazs Gyorffy　岸田健　大久保陽一郎　中村圭靖　宮城洋平
- Organizer
  第27回泌尿器科分子・細胞研究会
- Data Source
  KAKENHI-PROJECT-18K09168

1. SAIKA TAKASHI (10314676)

# of Collaborated Projects: 13 results

# of Collaborated Products: 19 results
2. Miura Noriyoshi (80554427)

# of Collaborated Projects: 10 results

# of Collaborated Products: 14 results
3. 東山繁樹 (60202272)

# of Collaborated Projects: 6 results

# of Collaborated Products: 7 results
4. 今井祐記 (10423873)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
5. 渡辺隆太 (00813635)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
6. Nishimura Kenichi (20868666)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 新井欧介 (00972910)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. 柳原裕太 (20865703)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. 酒井大史 (00820804)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 中畑和之 (20380256)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 飯尾浩之 (80972231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 角田俊雄 (70988435)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 沢田雄一郎 (80793554)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 中村匡徳 (20448046)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. HIEDA Miki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. OHKAWA Yasuyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 山下政克

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KIKUGAWA Tadahiko 菊川 忠彦

Kikugawa Tadahiko 菊川 忠彦

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腎癌関連血管内皮細胞におけるPSMAの発現制御機構及び、その分子機能の解明Principal Investigator

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International collaboration research on the identification of novel driver genes for prostate cancer by single cell analysis.Principal Investigator

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The identification of CUL3-SPOP and CUL3-PLZF target substrates for therapeutic targets in prostate cancer cellsPrincipal Investigator

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[Journal Article] Spatial Gene Expression Analysis Reveals Characteristic Gene Expression Patterns of De Novo Neuroendocrine Prostate Cancer Coexisting with Androgen Receptor Pathway Prostate Cancer2023

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[Journal Article] Senescent <scp>CD8</scp> <sup>+</sup> T cells acquire <scp>NK</scp> cell‐like innate functions to promote antitumor immunity2023

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KIKUGAWA Tadahiko 菊川忠彦

Kikugawa Tadahiko 菊川忠彦